[{"month":"09","publication_identifier":{"isbn":["9783540410041"],"eissn":["1611-3349"],"eisbn":["9783540452539"],"issn":["0302-9743"]},"title":"Web information retrieval - an algorithmic perspective","date_updated":"2023-02-13T12:08:21Z","year":"2000","conference":{"location":"Saarbrücken, Germany","start_date":"2000-09-05","end_date":"2000-09-08","name":"ESA: European Symposium on Algorithms"},"article_processing_charge":"No","date_published":"2000-09-01T00:00:00Z","author":[{"id":"540c9bbd-f2de-11ec-812d-d04a5be85630","first_name":"Monika H","full_name":"Henzinger, Monika H","orcid":"0000-0002-5008-6530","last_name":"Henzinger"}],"page":"1–8","oa_version":"None","publication":"8th Annual European Symposium on Algorithms","doi":"10.1007/3-540-45253-2_1","day":"01","date_created":"2022-08-11T13:25:07Z","_id":"11802","publisher":"Springer Nature","status":"public","language":[{"iso":"eng"}],"alternative_title":["LNCS"],"publication_status":"published","abstract":[{"text":"In this paper we survey algorithmic aspects of Web information retrieval. As an example, we discuss ranking of search engine results using connectivity analysis.","lang":"eng"}],"volume":1879,"intvolume":" 1879","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","quality_controlled":"1","extern":"1","citation":{"apa":"Henzinger, M. H. (2000). Web information retrieval - an algorithmic perspective. In 8th Annual European Symposium on Algorithms (Vol. 1879, pp. 1–8). Saarbrücken, Germany: Springer Nature. https://doi.org/10.1007/3-540-45253-2_1","short":"M.H. Henzinger, in:, 8th Annual European Symposium on Algorithms, Springer Nature, 2000, pp. 1–8.","ieee":"M. H. Henzinger, “Web information retrieval - an algorithmic perspective,” in 8th Annual European Symposium on Algorithms, Saarbrücken, Germany, 2000, vol. 1879, pp. 1–8.","ama":"Henzinger MH. Web information retrieval - an algorithmic perspective. In: 8th Annual European Symposium on Algorithms. Vol 1879. Springer Nature; 2000:1–8. doi:10.1007/3-540-45253-2_1","chicago":"Henzinger, Monika H. “Web Information Retrieval - an Algorithmic Perspective.” In 8th Annual European Symposium on Algorithms, 1879:1–8. Springer Nature, 2000. https://doi.org/10.1007/3-540-45253-2_1.","ista":"Henzinger MH. 2000. Web information retrieval - an algorithmic perspective. 8th Annual European Symposium on Algorithms. ESA: European Symposium on Algorithms, LNCS, vol. 1879, 1–8.","mla":"Henzinger, Monika H. “Web Information Retrieval - an Algorithmic Perspective.” 8th Annual European Symposium on Algorithms, vol. 1879, Springer Nature, 2000, pp. 1–8, doi:10.1007/3-540-45253-2_1."},"scopus_import":"1","type":"conference"},{"quality_controlled":"1","intvolume":" 29","issue":"6","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","volume":29,"publication_status":"published","abstract":[{"lang":"eng","text":"We present fully dynamic algorithms for maintaining the biconnected components in general and plane graphs.\r\n\r\nA fully dynamic algorithm maintains a graph during a sequence of insertions and deletions of edges or isolated vertices. Let m be the number of edges and n be the number of vertices in a graph. The time per operation of the best deterministic algorithms is 𝑂(𝑛√) in general graphs and O(log n) in plane graphs for fully dynamic connectivity and O(min m2/3 ,n}) in general graphs and 𝑂(𝑛√) in plane graphs for fully dynamic biconnectivity. We improve the later running times to 𝑂(𝑚log𝑛‾‾‾‾‾‾‾√) in general graphs and O(log 2n ) in plane graphs. Our algorithm for general graphscan also find the biconnected components of all vertices in time O(n)."}],"status":"public","language":[{"iso":"eng"}],"article_type":"original","extern":"1","type":"journal_article","citation":{"ieee":"M. H. Henzinger, “Improved data structures for fully dynamic biconnectivity,” SIAM Journal on Computing, vol. 29, no. 6. Society for Industrial & Applied Mathematics, pp. 1761–1815, 2000.","short":"M.H. Henzinger, SIAM Journal on Computing 29 (2000) 1761–1815.","apa":"Henzinger, M. H. (2000). Improved data structures for fully dynamic biconnectivity. SIAM Journal on Computing. Society for Industrial & Applied Mathematics. https://doi.org/10.1137/s0097539794263907","mla":"Henzinger, Monika H. “Improved Data Structures for Fully Dynamic Biconnectivity.” SIAM Journal on Computing, vol. 29, no. 6, Society for Industrial & Applied Mathematics, 2000, pp. 1761–815, doi:10.1137/s0097539794263907.","ista":"Henzinger MH. 2000. Improved data structures for fully dynamic biconnectivity. SIAM Journal on Computing. 29(6), 1761–1815.","chicago":"Henzinger, Monika H. “Improved Data Structures for Fully Dynamic Biconnectivity.” SIAM Journal on Computing. Society for Industrial & Applied Mathematics, 2000. https://doi.org/10.1137/s0097539794263907.","ama":"Henzinger MH. Improved data structures for fully dynamic biconnectivity. SIAM Journal on Computing. 2000;29(6):1761-1815. doi:10.1137/s0097539794263907"},"scopus_import":"1","year":"2000","article_processing_charge":"No","date_published":"2000-11-01T00:00:00Z","author":[{"first_name":"Monika H","id":"540c9bbd-f2de-11ec-812d-d04a5be85630","full_name":"Henzinger, Monika H","orcid":"0000-0002-5008-6530","last_name":"Henzinger"}],"publication_identifier":{"eissn":["1095-7111"],"issn":["0097-5397"]},"title":"Improved data structures for fully dynamic biconnectivity","date_updated":"2023-02-17T14:39:47Z","month":"11","publisher":"Society for Industrial & Applied Mathematics","_id":"11893","day":"01","date_created":"2022-08-17T08:45:41Z","publication":"SIAM Journal on Computing","doi":"10.1137/s0097539794263907","page":"1761-1815","oa_version":"None"},{"publisher":"American Mathematical Society","_id":"2325","date_created":"2018-12-11T11:57:00Z","day":"01","doi":"10.1090/conm/529","page":"53 - 72","author":[{"full_name":"Robert Seiringer","orcid":"0000-0002-6781-0521","last_name":"Seiringer","first_name":"Robert","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87"}],"date_published":"2000-01-01T00:00:00Z","conference":{"name":"Arizona School of Analysis With Applications"},"year":"2000","date_updated":"2021-01-12T06:56:47Z","title":"Inequalities for Schrödinger operators and applications to the stability of matter problem ","month":"01","citation":{"apa":"Seiringer, R. (2000). Inequalities for Schrödinger operators and applications to the stability of matter problem (Vol. 529, pp. 53–72). Presented at the Arizona School of Analysis With Applications, American Mathematical Society. https://doi.org/10.1090/conm/529","short":"R. Seiringer, in:, American Mathematical Society, 2000, pp. 53–72.","ieee":"R. Seiringer, “Inequalities for Schrödinger operators and applications to the stability of matter problem ,” presented at the Arizona School of Analysis With Applications, 2000, vol. 529, pp. 53–72.","chicago":"Seiringer, Robert. “Inequalities for Schrödinger Operators and Applications to the Stability of Matter Problem ,” 529:53–72. American Mathematical Society, 2000. https://doi.org/10.1090/conm/529.","ama":"Seiringer R. Inequalities for Schrödinger operators and applications to the stability of matter problem . In: Vol 529. American Mathematical Society; 2000:53-72. doi:10.1090/conm/529","ista":"Seiringer R. 2000. Inequalities for Schrödinger operators and applications to the stability of matter problem . Arizona School of Analysis With Applications, Contemporary Mathematics, vol. 529, 53–72.","mla":"Seiringer, Robert. Inequalities for Schrödinger Operators and Applications to the Stability of Matter Problem . Vol. 529, American Mathematical Society, 2000, pp. 53–72, doi:10.1090/conm/529."},"type":"conference","extern":1,"quality_controlled":0,"intvolume":" 529","alternative_title":["Contemporary Mathematics"],"publication_status":"published","volume":529,"publist_id":"4602","status":"public"},{"title":"The ground state energy and density of interacting bosons in a trap","date_updated":"2023-05-03T13:00:35Z","publication_identifier":{"isbn":["9789810242374 "]},"month":"06","date_published":"2000-06-01T00:00:00Z","author":[{"full_name":"Seiringer, Robert","orcid":"0000-0002-6781-0521","last_name":"Seiringer","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","first_name":"Robert"},{"first_name":"Élliott","full_name":"Lieb, Élliott","last_name":"Lieb"},{"full_name":"Yngvason, Jakob","last_name":"Yngvason","first_name":"Jakob"}],"article_processing_charge":"No","conference":{"name":"ISQTS: Quantum Theory and Symmetries"},"year":"2000","publication":"Proceedings of the International Symposium on Quantum Theory and Symmetries","oa_version":"None","page":"101 - 110","arxiv":1,"_id":"2342","publisher":"World Scientific Publishing","date_created":"2018-12-11T11:57:06Z","external_id":{"arxiv":["math-ph/9911026"]},"day":"01","abstract":[{"text":"In the theoretical description of recent experiments with dilute Bose gases confined in external potentials the Gross-Pitaevskii equation plays an important role. Its status as an approximation for the quantum mechanical many-body ground state problem has recently been rigorously clarified. A summary of this work is presented here.","lang":"eng"}],"publication_status":"published","publist_id":"4584","main_file_link":[{"url":"http://arxiv.org/abs/math-ph/9911026","open_access":"1"}],"language":[{"iso":"eng"}],"status":"public","quality_controlled":"1","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","oa":1,"type":"conference","citation":{"ista":"Seiringer R, Lieb É, Yngvason J. 2000. The ground state energy and density of interacting bosons in a trap. Proceedings of the International Symposium on Quantum Theory and Symmetries. ISQTS: Quantum Theory and Symmetries, 101–110.","mla":"Seiringer, Robert, et al. “The Ground State Energy and Density of Interacting Bosons in a Trap.” Proceedings of the International Symposium on Quantum Theory and Symmetries, World Scientific Publishing, 2000, pp. 101–10.","chicago":"Seiringer, Robert, Élliott Lieb, and Jakob Yngvason. “The Ground State Energy and Density of Interacting Bosons in a Trap.” In Proceedings of the International Symposium on Quantum Theory and Symmetries, 101–10. World Scientific Publishing, 2000.","ama":"Seiringer R, Lieb É, Yngvason J. The ground state energy and density of interacting bosons in a trap. In: Proceedings of the International Symposium on Quantum Theory and Symmetries. World Scientific Publishing; 2000:101-110.","ieee":"R. Seiringer, É. Lieb, and J. Yngvason, “The ground state energy and density of interacting bosons in a trap,” in Proceedings of the International Symposium on Quantum Theory and Symmetries, 2000, pp. 101–110.","apa":"Seiringer, R., Lieb, É., & Yngvason, J. (2000). The ground state energy and density of interacting bosons in a trap. In Proceedings of the International Symposium on Quantum Theory and Symmetries (pp. 101–110). World Scientific Publishing.","short":"R. Seiringer, É. Lieb, J. Yngvason, in:, Proceedings of the International Symposium on Quantum Theory and Symmetries, World Scientific Publishing, 2000, pp. 101–110."},"extern":"1"},{"author":[{"first_name":"Bernhard","full_name":"Baumgartner, Bernhard","last_name":"Baumgartner"},{"last_name":"Seiringer","full_name":"Robert Seiringer","orcid":"0000-0002-6781-0521","first_name":"Robert","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87"}],"date_published":"2000-11-01T00:00:00Z","year":"2000","month":"11","date_updated":"2021-01-12T06:56:54Z","title":"On the ordering of energy levels in homogeneous magnetic fields","date_created":"2018-12-11T11:57:06Z","day":"01","_id":"2343","publisher":"Springer","page":"213 - 226","publication":"Letters in Mathematical Physics","doi":" 10.1023/A:1010978807635","issue":"3","intvolume":" 54","oa":1,"quality_controlled":0,"status":"public","abstract":[{"lang":"eng","text":"We study the energy levels of a single particle in a homogeneous magnetic field and in an axially symmetric external potential. For potentials that are superharmonic off the central axis, we find a general 'pseudoconcave' ordering of the ground state energies of the Hamiltonian restricted to the sectors with fixed angular momentum. The physical applications include atoms and ions in strong magnetic fields. There the energies are monotone increasing and concave in angular momentum. In the case of a periodic chain of atoms, the pseudoconcavity extends to the entire lowest band of Bloch functions."}],"volume":54,"publication_status":"published","publist_id":"4582","main_file_link":[{"url":"http://arxiv.org/abs/math-ph/0011031","open_access":"1"}],"type":"journal_article","citation":{"mla":"Baumgartner, Bernhard, and Robert Seiringer. “On the Ordering of Energy Levels in Homogeneous Magnetic Fields.” Letters in Mathematical Physics, vol. 54, no. 3, Springer, 2000, pp. 213–26, doi:    10.1023/A:1010978807635.","ista":"Baumgartner B, Seiringer R. 2000. On the ordering of energy levels in homogeneous magnetic fields. Letters in Mathematical Physics. 54(3), 213–226.","chicago":"Baumgartner, Bernhard, and Robert Seiringer. “On the Ordering of Energy Levels in Homogeneous Magnetic Fields.” Letters in Mathematical Physics. Springer, 2000. https://doi.org/    10.1023/A:1010978807635.","ama":"Baumgartner B, Seiringer R. On the ordering of energy levels in homogeneous magnetic fields. Letters in Mathematical Physics. 2000;54(3):213-226. doi:    10.1023/A:1010978807635","ieee":"B. Baumgartner and R. Seiringer, “On the ordering of energy levels in homogeneous magnetic fields,” Letters in Mathematical Physics, vol. 54, no. 3. Springer, pp. 213–226, 2000.","short":"B. Baumgartner, R. Seiringer, Letters in Mathematical Physics 54 (2000) 213–226.","apa":"Baumgartner, B., & Seiringer, R. (2000). On the ordering of energy levels in homogeneous magnetic fields. Letters in Mathematical Physics. Springer. https://doi.org/    10.1023/A:1010978807635"},"extern":1},{"publisher":"American Physical Society","day":"01","doi":"10.1103/PhysRevA.61.043602","oa_version":"Published Version","arxiv":1,"author":[{"last_name":"Lieb","full_name":"Lieb, Élliott","first_name":"Élliott"},{"last_name":"Seiringer","full_name":"Seiringer, Robert","orcid":"0000-0002-6781-0521","first_name":"Robert","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Yngvason","full_name":"Yngvason, Jakob","first_name":"Jakob"}],"year":"2000","publication_identifier":{"issn":["0556-2791"]},"article_type":"original","type":"journal_article","citation":{"apa":"Lieb, É., Seiringer, R., & Yngvason, J. (2000). Bosons in a trap: A rigorous derivation of the Gross-Pitaevskii energy functional. Physical Review A - Atomic, Molecular, and Optical Physics. American Physical Society. https://doi.org/10.1103/PhysRevA.61.043602","short":"É. Lieb, R. Seiringer, J. Yngvason, Physical Review A - Atomic, Molecular, and Optical Physics 61 (2000) 436021–4360213.","ieee":"É. Lieb, R. Seiringer, and J. Yngvason, “Bosons in a trap: A rigorous derivation of the Gross-Pitaevskii energy functional,” Physical Review A - Atomic, Molecular, and Optical Physics, vol. 61, no. 4. American Physical Society, pp. 436021–4360213, 2000.","chicago":"Lieb, Élliott, Robert Seiringer, and Jakob Yngvason. “Bosons in a Trap: A Rigorous Derivation of the Gross-Pitaevskii Energy Functional.” Physical Review A - Atomic, Molecular, and Optical Physics. American Physical Society, 2000. https://doi.org/10.1103/PhysRevA.61.043602.","ama":"Lieb É, Seiringer R, Yngvason J. Bosons in a trap: A rigorous derivation of the Gross-Pitaevskii energy functional. Physical Review A - Atomic, Molecular, and Optical Physics. 2000;61(4):436021-4360213. doi:10.1103/PhysRevA.61.043602","mla":"Lieb, Élliott, et al. “Bosons in a Trap: A Rigorous Derivation of the Gross-Pitaevskii Energy Functional.” Physical Review A - Atomic, Molecular, and Optical Physics, vol. 61, no. 4, American Physical Society, 2000, pp. 436021–4360213, doi:10.1103/PhysRevA.61.043602.","ista":"Lieb É, Seiringer R, Yngvason J. 2000. Bosons in a trap: A rigorous derivation of the Gross-Pitaevskii energy functional. Physical Review A - Atomic, Molecular, and Optical Physics. 61(4), 436021–4360213."},"quality_controlled":"1","abstract":[{"text":"The ground-state properties of interacting Bose gases in external potentials, as considered in recent experiments, are usually described by means of the Gross-Pitaevskii energy functional. We present here a rigorous proof of the asymptotic exactness of this approximation for the ground-state energy and particle density of a dilute Bose gas with a positive interaction.","lang":"eng"}],"publication_status":"published","publist_id":"4583","language":[{"iso":"eng"}],"status":"public","_id":"2344","date_created":"2018-12-11T11:57:07Z","external_id":{"arxiv":["math-ph/9908027"]},"publication":"Physical Review A - Atomic, Molecular, and Optical Physics","page":"436021 - 4360213","date_published":"2000-04-01T00:00:00Z","article_processing_charge":"No","date_updated":"2023-05-03T12:47:08Z","title":"Bosons in a trap: A rigorous derivation of the Gross-Pitaevskii energy functional","month":"04","scopus_import":"1","extern":"1","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","issue":"4","intvolume":" 61","oa":1,"volume":61,"main_file_link":[{"open_access":"1","url":"http://arxiv.org/abs/math-ph/9908027"}]},{"page":"50 - 56","oa_version":"None","doi":"10.1145/336154.336176","publication":"Proceedings of the 16th annual symposium on Computational geometry","date_created":"2018-12-11T11:57:33Z","day":"01","publisher":"ACM","_id":"2418","month":"05","date_updated":"2023-05-03T12:41:02Z","title":"Origin-embracing distributions or a continuous analogue of the Upper Bound Theorem","publication_identifier":{"isbn":["9781581132243"]},"date_published":"2000-05-01T00:00:00Z","author":[{"first_name":"Uli","id":"36690CA2-F248-11E8-B48F-1D18A9856A87","full_name":"Wagner, Uli","orcid":"0000-0002-1494-0568","last_name":"Wagner"},{"full_name":"Welzl, Emo","last_name":"Welzl","first_name":"Emo"}],"year":"2000","conference":{"name":"SCG: Symposium on Computational Geometry","location":"Clear Water Bay Kowloon, Hong Kong","start_date":"2000-06-12","end_date":"2000-04-14"},"article_processing_charge":"No","scopus_import":"1","citation":{"ista":"Wagner U, Welzl E. 2000. Origin-embracing distributions or a continuous analogue of the Upper Bound Theorem. Proceedings of the 16th annual symposium on Computational geometry. SCG: Symposium on Computational Geometry, 50–56.","mla":"Wagner, Uli, and Emo Welzl. “Origin-Embracing Distributions or a Continuous Analogue of the Upper Bound Theorem.” Proceedings of the 16th Annual Symposium on Computational Geometry, ACM, 2000, pp. 50–56, doi:10.1145/336154.336176.","chicago":"Wagner, Uli, and Emo Welzl. “Origin-Embracing Distributions or a Continuous Analogue of the Upper Bound Theorem.” In Proceedings of the 16th Annual Symposium on Computational Geometry, 50–56. ACM, 2000. https://doi.org/10.1145/336154.336176.","ama":"Wagner U, Welzl E. Origin-embracing distributions or a continuous analogue of the Upper Bound Theorem. In: Proceedings of the 16th Annual Symposium on Computational Geometry. ACM; 2000:50-56. doi:10.1145/336154.336176","ieee":"U. Wagner and E. Welzl, “Origin-embracing distributions or a continuous analogue of the Upper Bound Theorem,” in Proceedings of the 16th annual symposium on Computational geometry, Clear Water Bay Kowloon, Hong Kong, 2000, pp. 50–56.","apa":"Wagner, U., & Welzl, E. (2000). Origin-embracing distributions or a continuous analogue of the Upper Bound Theorem. In Proceedings of the 16th annual symposium on Computational geometry (pp. 50–56). Clear Water Bay Kowloon, Hong Kong: ACM. https://doi.org/10.1145/336154.336176","short":"U. Wagner, E. Welzl, in:, Proceedings of the 16th Annual Symposium on Computational Geometry, ACM, 2000, pp. 50–56."},"type":"conference","extern":"1","language":[{"iso":"eng"}],"status":"public","publication_status":"published","abstract":[{"text":"For an absolutely continuous probability measure μ on Rd and a nonnegative integer k, let sk(μ, 0) denote the probability that the convex hull of k+d+1 random points which are i.i.d. according to μ contains the origin 0. For d and k given, we determine a tight upper bound on sk(μ, 0), and we characterize the measures in Rd which attain this bound. This result can be considered a continuous analogue of the Upper Bound Theorem for the maximal number of faces of convex polytopes with a given number of vertices. For our proof we introduce so-called h-functions, continuous counterparts of h-vectors for simplicial convex polytopes.","lang":"eng"}],"publist_id":"4507","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","quality_controlled":"1"},{"extern":"1","citation":{"ama":"Shigemoto R, Mizuno N. Chapter III Metabotropic glutamate receptors - immunocytochemical and in situ hybridization analyses. In: Glutamate. Vol 18. Elsevier; 2000:63-98. doi:10.1016/S0924-8196(00)80044-5","chicago":"Shigemoto, Ryuichi, and Noboru Mizuno. “Chapter III Metabotropic Glutamate Receptors - Immunocytochemical and in Situ Hybridization Analyses.” In Glutamate, 18:63–98. Elsevier, 2000. https://doi.org/10.1016/S0924-8196(00)80044-5.","mla":"Shigemoto, Ryuichi, and Noboru Mizuno. “Chapter III Metabotropic Glutamate Receptors - Immunocytochemical and in Situ Hybridization Analyses.” Glutamate, vol. 18, Elsevier, 2000, pp. 63–98, doi:10.1016/S0924-8196(00)80044-5.","ista":"Shigemoto R, Mizuno N. 2000.Chapter III Metabotropic glutamate receptors - immunocytochemical and in situ hybridization analyses. In: Glutamate. Handbook of Chemical Neuroanatomy, vol. 18, 63–98.","apa":"Shigemoto, R., & Mizuno, N. (2000). Chapter III Metabotropic glutamate receptors - immunocytochemical and in situ hybridization analyses. In Glutamate (Vol. 18, pp. 63–98). Elsevier. https://doi.org/10.1016/S0924-8196(00)80044-5","short":"R. Shigemoto, N. Mizuno, in:, Glutamate, Elsevier, 2000, pp. 63–98.","ieee":"R. Shigemoto and N. Mizuno, “Chapter III Metabotropic glutamate receptors - immunocytochemical and in situ hybridization analyses,” in Glutamate, vol. 18, Elsevier, 2000, pp. 63–98."},"type":"book_chapter","publist_id":"4407","publication_status":"published","volume":18,"abstract":[{"text":"This chapter focuses on metabotropic glutamate receptors (mGluRs). These receptors are linked to several intracellular signal transduction mechanisms via G-protein and are implicated in diverse functions of the mammalian central nervous system (CNS). These functions include mediation of slow excitatory and inhibitory responses; regulation of calcium channels, potassium channels, and non-selective cation channels; inhibition and facilitation of transmitter release; induction of long-term potentiation and long-term depression; and regulation of neuronal development. Functional diversity of the metabotropic glutamate receptor is reflected in molecular diversity of receptor subtypes. The sites of action of mGluRs are widely found throughout different membrane compartments of neuronal and glial cells. The chapter reviews the differential subcellular localization of metabotropic glutamate receptors in relation to transmitter release sites. Patterns of subcellular localization of mGluRs are different among three subgroups: group I and III mGluRs are mainly localized to somatodendritic and axonal domains of neurons, respectively, while group II mGluRs are extensively localized to both domains as well as to glial cell processes.","lang":"eng"}],"alternative_title":["Handbook of Chemical Neuroanatomy"],"status":"public","language":[{"iso":"eng"}],"quality_controlled":"1","intvolume":" 18","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","doi":"10.1016/S0924-8196(00)80044-5","publication":"Glutamate","page":"63 - 98","oa_version":"None","publisher":"Elsevier","_id":"2494","day":"01","date_created":"2018-12-11T11:58:00Z","publication_identifier":{"eissn":["0924-8196"]},"date_updated":"2023-05-03T12:27:40Z","title":"Chapter III Metabotropic glutamate receptors - immunocytochemical and in situ hybridization analyses","month":"01","article_processing_charge":"No","year":"2000","date_published":"2000-01-01T00:00:00Z","author":[{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444","last_name":"Shigemoto"},{"first_name":"Noboru","full_name":"Mizuno, Noboru","last_name":"Mizuno"}]},{"title":"Paraneoplastic cerebellar ataxia due to autoantibodies against a glutamate receptor","date_updated":"2023-05-03T11:14:19Z","month":"01","date_published":"2000-01-06T00:00:00Z","article_processing_charge":"No","publication":"New England Journal of Medicine","page":"21 - 27","_id":"2598","date_created":"2018-12-11T11:58:35Z","external_id":{"pmid":["10620645"]},"volume":342,"main_file_link":[{"url":"https://www.nejm.org/doi/full/10.1056/nejm200001063420104","open_access":"1"}],"acknowledgement":"Supported in part by the Ministry of Education, Science, and Culture of Japan (Dr. Nakanishi and Dr. Shigemoto); CREST of Japan Science and Technology Corporation (Dr. Shigemoto); the Life Sciences Foundation (Dr. De Zeeuw); NWO (Dr. De Zeeuw and Dr. De Leeuw); and the Human Frontier Science Program (Dr. De Zeeuw and Dr. Shigemoto).\r\nDrs. Sillevis Smitt and Kinoshita contributed equally to the article. We are indebted to A. Aiba for providing mGluR1-deficient mice; to T. Maruyama for providing human mGluR1-expressing CHO cells; to H. Jingami for helpful discussion; to A. Uesugi for photographic assistance; to M. van den Bent and C. Gaillard for clinical information on the patients; and to J. van der Burg, S.K.E. Koekkoek, K.J. Reus, and C. Vermeer for technical assistance.","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","issue":"1","oa":1,"intvolume":" 342","scopus_import":"1","extern":"1","publication_identifier":{"issn":["0028-4793"]},"author":[{"full_name":"Sillevis Smitt, Peter","last_name":"Sillevis Smitt","first_name":"Peter"},{"full_name":"Kinoshita, Ayae","last_name":"Kinoshita","first_name":"Ayae"},{"first_name":"Bertie","last_name":"De Leeuw","full_name":"De Leeuw, Bertie"},{"full_name":"Moll, Wiebe","last_name":"Moll","first_name":"Wiebe"},{"last_name":"Coesmans","full_name":"Coesmans, Michiel","first_name":"Michiel"},{"full_name":"Jaarsma, Dick","last_name":"Jaarsma","first_name":"Dick"},{"first_name":"Sonja","last_name":"Henzen Logmans","full_name":"Henzen Logmans, Sonja"},{"full_name":"Vecht, Charles","last_name":"Vecht","first_name":"Charles"},{"first_name":"Chris","last_name":"De Zeeuw","full_name":"De Zeeuw, Chris"},{"first_name":"Naotaka","last_name":"Sekiyama","full_name":"Sekiyama, Naotaka"},{"first_name":"Shigetada","last_name":"Nakanishi","full_name":"Nakanishi, Shigetada"},{"last_name":"Shigemoto","orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi"}],"year":"2000","doi":"10.1056/NEJM200001063420104","oa_version":"None","publisher":"Massachussetts Medical Society","day":"06","abstract":[{"text":"There are many types of cerebellar ataxia, including ataxia due to congenital or metabolic disorders and a paraneoplastic form in patients with gynecologic cancer, breast cancer, lung cancer, or Hodgkin's disease.1 This paraneoplastic syndrome is the only type of cerebellar ataxia associated with autoantibodies against neuronal antigens. Often, the neuronal antigens are aberrantly expressed by the tumor cells.2-4 The antineuronal autoantibodies are believed to cause cerebellar ataxia, but this is unproved.5,6 In Hodgkin's disease, the lymphoma precedes the ataxia by months to years in 80 percent of patients, and ataxia often occurs during a prolonged complete remission.4 Among patients with this type of ataxia, 30 percent have anti–Purkinje-cell antibodies, some of which have the features of the neuronal antibody anti-Tr.4,7\r\n\r\nWe identified a new autoantibody in two patients with severe cerebellar ataxia that developed while they were in remission from Hodgkin's disease. The antibody reacts specifically with the metabotropic glutamate receptor mGluR1 in mouse brain. Metabotropic glutamate receptors belong to a large family of cell-surface receptors that transmit signals into the cell by coupling to guanine nucleotide-binding proteins (G proteins) in the cytoplasm. Purified IgG from the serum of both patients blocked the glutamate-stimulated formation of inositol phosphates in Chinese-hamster-ovary (CHO) cells that expressed mGluR1α, and the injection of IgG from serum or cerebrospinal fluid into the cerebellar subarachnoid space of mice caused severe, reversible ataxia. These results indicate that antineuronal autoantibodies can cause disease of the central nervous system by blocking neuronal receptors.","lang":"eng"}],"publication_status":"published","publist_id":"4300","language":[{"iso":"eng"}],"pmid":1,"status":"public","quality_controlled":"1","citation":{"mla":"Sillevis Smitt, Peter, et al. “Paraneoplastic Cerebellar Ataxia Due to Autoantibodies against a Glutamate Receptor.” New England Journal of Medicine, vol. 342, no. 1, Massachussetts Medical Society, 2000, pp. 21–27, doi:10.1056/NEJM200001063420104.","ista":"Sillevis Smitt P, Kinoshita A, De Leeuw B, Moll W, Coesmans M, Jaarsma D, Henzen Logmans S, Vecht C, De Zeeuw C, Sekiyama N, Nakanishi S, Shigemoto R. 2000. Paraneoplastic cerebellar ataxia due to autoantibodies against a glutamate receptor. New England Journal of Medicine. 342(1), 21–27.","chicago":"Sillevis Smitt, Peter, Ayae Kinoshita, Bertie De Leeuw, Wiebe Moll, Michiel Coesmans, Dick Jaarsma, Sonja Henzen Logmans, et al. “Paraneoplastic Cerebellar Ataxia Due to Autoantibodies against a Glutamate Receptor.” New England Journal of Medicine. Massachussetts Medical Society, 2000. https://doi.org/10.1056/NEJM200001063420104.","ama":"Sillevis Smitt P, Kinoshita A, De Leeuw B, et al. Paraneoplastic cerebellar ataxia due to autoantibodies against a glutamate receptor. New England Journal of Medicine. 2000;342(1):21-27. doi:10.1056/NEJM200001063420104","ieee":"P. Sillevis Smitt et al., “Paraneoplastic cerebellar ataxia due to autoantibodies against a glutamate receptor,” New England Journal of Medicine, vol. 342, no. 1. Massachussetts Medical Society, pp. 21–27, 2000.","apa":"Sillevis Smitt, P., Kinoshita, A., De Leeuw, B., Moll, W., Coesmans, M., Jaarsma, D., … Shigemoto, R. (2000). Paraneoplastic cerebellar ataxia due to autoantibodies against a glutamate receptor. New England Journal of Medicine. Massachussetts Medical Society. https://doi.org/10.1056/NEJM200001063420104","short":"P. Sillevis Smitt, A. Kinoshita, B. De Leeuw, W. Moll, M. Coesmans, D. Jaarsma, S. Henzen Logmans, C. Vecht, C. De Zeeuw, N. Sekiyama, S. Nakanishi, R. Shigemoto, New England Journal of Medicine 342 (2000) 21–27."},"type":"journal_article","article_type":"original"},{"date_published":"2000-03-06T00:00:00Z","article_processing_charge":"No","month":"03","title":"Relationship between neurokinin-1 receptor and substance P in the striatum: Light and electron microscopic immunohistochemical study in the rat","date_updated":"2023-05-03T10:56:44Z","date_created":"2018-12-11T11:58:36Z","external_id":{"pmid":["10701441"]},"_id":"2599","page":"156 - 163","publication":"Journal of Comparative Neurology","acknowledgement":"The authors are grateful for the photographic help of Ms. Yue-Ping Yuan, Mr. Akira Uesugi, Ms. Keiko Oka-moto, Mr. Nobuyuki Kobayashi, and Mr. Hideki Itabashi. The authors also express their gratitudes for the support of Dr. Kajitaro Morita in Morita Clinic of Internal Medicine and Pediatrics, Kadoma, Osaka, Japan","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","issue":"2","intvolume":" 418","volume":418,"scopus_import":"1","extern":"1","author":[{"first_name":"Jin","full_name":"Li, Jin","last_name":"Li"},{"last_name":"Wang","full_name":"Wang, Dan","first_name":"Dan"},{"last_name":"Kaneko","full_name":"Kaneko, Takeshi","first_name":"Takeshi"},{"full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444","last_name":"Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi"},{"first_name":"Sakashi","full_name":"Nomura, Sakashi","last_name":"Nomura"},{"first_name":"Noboru","last_name":"Mizuno","full_name":"Mizuno, Noboru"}],"year":"2000","publication_identifier":{"issn":["0021-9967"]},"day":"06","publisher":"Wiley-Blackwell","oa_version":"None","doi":"10.1002/(SICI)1096-9861(20000306)418:2<156::AID-CNE3>3.0.CO;2-Z","quality_controlled":"1","language":[{"iso":"eng"}],"pmid":1,"status":"public","publication_status":"published","abstract":[{"text":"The synaptic relationship between substance P (SP) and its receptor, i.e., neurokinin-1 receptor (NK1R), was examined in the striatum of the rat by confocal laser-scanning microscopy and electron microscopy. For confocal laser-scanning microscopy, triple-immunofluorescence histochemistry was performed to label NK1R, SP, and vesicular acetylcholine transporter (a specific marker for cholinergic neurons). In electron microscopic double- immunolabeling study, immunoreactivity for NK1R was detected with the silver- intensified gold method, while immunoreactivity for SP was detected with peroxidase immunohistochemistry. Simultaneous immunolabeling of NK1R and SP revealed significant mismatch at the synaptic level: although some SP- immunopositive axon terminals were in synaptic contact with NK1R- immunopositive sites of plasma membrane, NK1R-immunoreactivity was observed at both synaptic and non-synaptic sites of plasma membrane. Thus, SP released from the sites remote from NK1Rs might diffuse in the extracellular fluid to act, as a paracrine neurotransmitter, on NK1Rs distant from its releasing site. SP neurotransmission in the striatum might occur not only synaptically but also extrasynaptically. The SP-NK1R system might constitute an association system within the striatum.","lang":"eng"}],"publist_id":"4299","article_type":"original","type":"journal_article","citation":{"ama":"Li J, Wang D, Kaneko T, Shigemoto R, Nomura S, Mizuno N. Relationship between neurokinin-1 receptor and substance P in the striatum: Light and electron microscopic immunohistochemical study in the rat. Journal of Comparative Neurology. 2000;418(2):156-163. doi:10.1002/(SICI)1096-9861(20000306)418:2&lt;156::AID-CNE3&gt;3.0.CO;2-Z","chicago":"Li, Jin, Dan Wang, Takeshi Kaneko, Ryuichi Shigemoto, Sakashi Nomura, and Noboru Mizuno. “Relationship between Neurokinin-1 Receptor and Substance P in the Striatum: Light and Electron Microscopic Immunohistochemical Study in the Rat.” Journal of Comparative Neurology. Wiley-Blackwell, 2000. https://doi.org/10.1002/(SICI)1096-9861(20000306)418:2&lt;156::AID-CNE3&gt;3.0.CO;2-Z.","ista":"Li J, Wang D, Kaneko T, Shigemoto R, Nomura S, Mizuno N. 2000. Relationship between neurokinin-1 receptor and substance P in the striatum: Light and electron microscopic immunohistochemical study in the rat. Journal of Comparative Neurology. 418(2), 156–163.","mla":"Li, Jin, et al. “Relationship between Neurokinin-1 Receptor and Substance P in the Striatum: Light and Electron Microscopic Immunohistochemical Study in the Rat.” Journal of Comparative Neurology, vol. 418, no. 2, Wiley-Blackwell, 2000, pp. 156–63, doi:10.1002/(SICI)1096-9861(20000306)418:2&lt;156::AID-CNE3&gt;3.0.CO;2-Z.","short":"J. Li, D. Wang, T. Kaneko, R. Shigemoto, S. Nomura, N. Mizuno, Journal of Comparative Neurology 418 (2000) 156–163.","apa":"Li, J., Wang, D., Kaneko, T., Shigemoto, R., Nomura, S., & Mizuno, N. (2000). Relationship between neurokinin-1 receptor and substance P in the striatum: Light and electron microscopic immunohistochemical study in the rat. Journal of Comparative Neurology. Wiley-Blackwell. https://doi.org/10.1002/(SICI)1096-9861(20000306)418:2&lt;156::AID-CNE3&gt;3.0.CO;2-Z","ieee":"J. Li, D. Wang, T. Kaneko, R. Shigemoto, S. Nomura, and N. Mizuno, “Relationship between neurokinin-1 receptor and substance P in the striatum: Light and electron microscopic immunohistochemical study in the rat,” Journal of Comparative Neurology, vol. 418, no. 2. Wiley-Blackwell, pp. 156–163, 2000."}},{"volume":36,"intvolume":" 36","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","issue":"4","extern":"1","scopus_import":"1","month":"04","date_updated":"2023-05-03T10:47:06Z","title":"The relationship between neurokinin-1 receptor and substance P in the medullary dorsal horn: A light and electron microscopic immunohistochemical study in the rat","article_processing_charge":"No","date_published":"2000-04-01T00:00:00Z","page":"327 - 334","publication":"Neuroscience Research","external_id":{"pmid":["10771111"]},"date_created":"2018-12-11T11:58:36Z","_id":"2600","pmid":1,"status":"public","language":[{"iso":"eng"}],"publist_id":"4298","publication_status":"published","abstract":[{"text":"The synaptic relationship between substance P (SP) and its receptor, i.e. neurokinin-1 receptor (NK1R), was examined in the superficial laminae of the caudal subnucleus of the spinal trigeminal nucleus (medullary dorsal horn; MDH) of the rat. For confocal laser-scanning microscopy, double-immunofluorescence histochemistry for NK1 and SP was performed. In electron microscopic double-immunolabeling study, immunoreactivity for NK1R was detected with the silver-intensified gold method, while immunoreactivity for SP was detected with peroxidase immunohistochemistry. SP-immunoreactive axon terminals were observed to be in synaptic (mostly asymmetric) contact with NK1R-immunoreactive neuronal profiles in lamina I and lamina IIo. Although some SP-immunoreactive axon terminals were in synaptic contact with NK1R-immunoreactive sites of plasma membranes, NK1R-immunoreactivity was observed at both synaptic and non-synaptic sites of plasma membrane. Thus, SP released from axon terminals might not only act on NK1Rs facing the SP-containing axon terminals, but also diffuse in the extracellular fluid for distances larger than the synaptic cleft to act on NK1Rs at some distances from the synaptic sites. ","lang":"eng"}],"quality_controlled":"1","citation":{"ama":"Li J, Wang D, Kaneko T, Shigemoto R, Nomura S, Mizuno N. The relationship between neurokinin-1 receptor and substance P in the medullary dorsal horn: A light and electron microscopic immunohistochemical study in the rat. Neuroscience Research. 2000;36(4):327-334. doi:10.1016/S0168-0102(00)00095-X","chicago":"Li, Jin, Dan Wang, Takeshi Kaneko, Ryuichi Shigemoto, Sakashi Nomura, and Noboru Mizuno. “The Relationship between Neurokinin-1 Receptor and Substance P in the Medullary Dorsal Horn: A Light and Electron Microscopic Immunohistochemical Study in the Rat.” Neuroscience Research. Elsevier, 2000. https://doi.org/10.1016/S0168-0102(00)00095-X.","ista":"Li J, Wang D, Kaneko T, Shigemoto R, Nomura S, Mizuno N. 2000. The relationship between neurokinin-1 receptor and substance P in the medullary dorsal horn: A light and electron microscopic immunohistochemical study in the rat. Neuroscience Research. 36(4), 327–334.","mla":"Li, Jin, et al. “The Relationship between Neurokinin-1 Receptor and Substance P in the Medullary Dorsal Horn: A Light and Electron Microscopic Immunohistochemical Study in the Rat.” Neuroscience Research, vol. 36, no. 4, Elsevier, 2000, pp. 327–34, doi:10.1016/S0168-0102(00)00095-X.","apa":"Li, J., Wang, D., Kaneko, T., Shigemoto, R., Nomura, S., & Mizuno, N. (2000). The relationship between neurokinin-1 receptor and substance P in the medullary dorsal horn: A light and electron microscopic immunohistochemical study in the rat. Neuroscience Research. Elsevier. https://doi.org/10.1016/S0168-0102(00)00095-X","short":"J. Li, D. Wang, T. Kaneko, R. Shigemoto, S. Nomura, N. Mizuno, Neuroscience Research 36 (2000) 327–334.","ieee":"J. Li, D. Wang, T. Kaneko, R. Shigemoto, S. Nomura, and N. Mizuno, “The relationship between neurokinin-1 receptor and substance P in the medullary dorsal horn: A light and electron microscopic immunohistochemical study in the rat,” Neuroscience Research, vol. 36, no. 4. Elsevier, pp. 327–334, 2000."},"type":"journal_article","article_type":"original","publication_identifier":{"issn":["0168-0102"]},"year":"2000","author":[{"first_name":"Jin","full_name":"Li, Jin","last_name":"Li"},{"full_name":"Wang, Dan","last_name":"Wang","first_name":"Dan"},{"first_name":"Takeshi","last_name":"Kaneko","full_name":"Kaneko, Takeshi"},{"last_name":"Shigemoto","orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Nomura, Sakashi","last_name":"Nomura","first_name":"Sakashi"},{"full_name":"Mizuno, Noboru","last_name":"Mizuno","first_name":"Noboru"}],"oa_version":"None","doi":"10.1016/S0168-0102(00)00095-X","day":"01","publisher":"Elsevier"},{"publication_identifier":{"issn":["0036-8075"]},"year":"2000","author":[{"last_name":"Ichise","full_name":"Ichise, Taeko","first_name":"Taeko"},{"last_name":"Kano","full_name":"Kano, Masanobu","first_name":"Masanobu"},{"full_name":"Hashimoto, Kouichi","last_name":"Hashimoto","first_name":"Kouichi"},{"full_name":"Yanagihara, Dai","last_name":"Yanagihara","first_name":"Dai"},{"full_name":"Nakao, Kazuki","last_name":"Nakao","first_name":"Kazuki"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi","last_name":"Shigemoto"},{"full_name":"Katsuki, Motoya","last_name":"Katsuki","first_name":"Motoya"},{"first_name":"Atsu","last_name":"Aiba","full_name":"Aiba, Atsu"}],"oa_version":"None","doi":"10.1126/science.288.5472.1832","day":"09","publisher":"American Association for the Advancement of Science","pmid":1,"status":"public","language":[{"iso":"eng"}],"publist_id":"4297","publication_status":"published","abstract":[{"text":"Targeted deletion of metabotropic glutamate receptor-subtype 1 (mGluR1) gene can cause defects in development and function in the cerebellum. We introduced the mGluR1α transgene into mGluR1-null mutant [mGluR1 (-/-)] mice with a Purkinje cell (PC)-specific promoter. mGluR1-rescue mice showed normal cerebellar long-term depression and regression of multiple climbing fiber innervation, events significantly impaired in mGluR1 (-/-) mice. The impaired motor coordination was rescued by this transgene, in a dose-dependent manner. We propose that mGluR1 in PCs is a key molecule for normal synapse formation, synaptic plasticity, and motor control in the cerebellum.","lang":"eng"}],"quality_controlled":"1","type":"journal_article","citation":{"ieee":"T. Ichise et al., “mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination,” Science, vol. 288, no. 5472. American Association for the Advancement of Science, pp. 1832–1835, 2000.","apa":"Ichise, T., Kano, M., Hashimoto, K., Yanagihara, D., Nakao, K., Shigemoto, R., … Aiba, A. (2000). mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination. Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.288.5472.1832","short":"T. Ichise, M. Kano, K. Hashimoto, D. Yanagihara, K. Nakao, R. Shigemoto, M. Katsuki, A. Aiba, Science 288 (2000) 1832–1835.","mla":"Ichise, Taeko, et al. “MGluR1 in Cerebellar Purkinje Cells Essential for Long-Term Depression, Synapse Elimination, and Motor Coordination.” Science, vol. 288, no. 5472, American Association for the Advancement of Science, 2000, pp. 1832–35, doi:10.1126/science.288.5472.1832.","ista":"Ichise T, Kano M, Hashimoto K, Yanagihara D, Nakao K, Shigemoto R, Katsuki M, Aiba A. 2000. mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination. Science. 288(5472), 1832–1835.","chicago":"Ichise, Taeko, Masanobu Kano, Kouichi Hashimoto, Dai Yanagihara, Kazuki Nakao, Ryuichi Shigemoto, Motoya Katsuki, and Atsu Aiba. “MGluR1 in Cerebellar Purkinje Cells Essential for Long-Term Depression, Synapse Elimination, and Motor Coordination.” Science. American Association for the Advancement of Science, 2000. https://doi.org/10.1126/science.288.5472.1832.","ama":"Ichise T, Kano M, Hashimoto K, et al. mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination. Science. 2000;288(5472):1832-1835. doi:10.1126/science.288.5472.1832"},"article_type":"original","month":"06","date_updated":"2023-05-03T09:53:38Z","title":"mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination","article_processing_charge":"No","date_published":"2000-06-09T00:00:00Z","page":"1832 - 1835","publication":"Science","external_id":{"pmid":["10846166 "]},"date_created":"2018-12-11T11:58:36Z","_id":"2601","volume":288,"intvolume":" 288","issue":"5472","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","extern":"1","scopus_import":"1"},{"pmid":1,"status":"public","language":[{"iso":"eng"}],"publist_id":"4296","publication_status":"published","abstract":[{"text":"Although presynaptic localization of mGluR7 is well established, the mechanism by which the receptor may control Ca2+ channels in neurons is still unknown. We show here that cultured cerebellar granule cells express native metabotropic glutamate receptor type 7 (mGluR7) in neuritic processes, whereas transfected mGluR7 was also expressed in cell bodies. This allowed us to study the effect of the transfected receptor on somatic Ca2+ channels. In transfected neurons, mGuR7 selectively inhibited P/Q-type Ca2+ channels. The effect was mimicked by GTPγS and blocked by pertussis toxin (PTX) or a selective antibody raised against the G-protein αo subunit, indicating the involvement of a G(o)-like protein. The mGuR7 effect did not display the characteristics of a direct interaction between G-protein βγ subunits and the α1A Ca2+ channel subunit, but was abolished by quenching βγ subunits with specific intracellular peptides. Intracellular dialysis of G-protein βγ subunits did not mimic the action of mGluR7, suggesting that both G-protein βγ and αo subunits were required to mediate the effect. Inhibition of phospholipase C (PLC) blocked the inhibitory action of mGluR7, suggesting that a coincident activation of PLC by the G-protein βγ with αo subunits was required. The Ca2+ chelator BAPTA, as well as inhibition of either the inositol trisphosphate (IP3) receptor or protein kinase C (PKC) abolished the mGluR7 effect. Moreover, activation of native mGluR7 induced a PTX-dependent IP3 formation. These results indicated that IP3-mediated intracellular Ca2+ release was required for PKC-dependent inhibition of the Ca2+ channels. Possible control of synaptic transmission by the present mechanisms is discussed.","lang":"eng"}],"quality_controlled":"1","type":"journal_article","citation":{"short":"J. Perroy, L. Prezèau, M. De Waard, R. Shigemoto, J. Bockaërt, L. Fagni, Journal of Neuroscience 20 (2000) 7896–7904.","apa":"Perroy, J., Prezèau, L., De Waard, M., Shigemoto, R., Bockaërt, J., & Fagni, L. (2000). Selective blockade of P/Q-type calcium channels by the metabotropic glutamate receptor type 7 involves a phospholipase C pathway in neurons. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.20-21-07896.2000","ieee":"J. Perroy, L. Prezèau, M. De Waard, R. Shigemoto, J. Bockaërt, and L. Fagni, “Selective blockade of P/Q-type calcium channels by the metabotropic glutamate receptor type 7 involves a phospholipase C pathway in neurons,” Journal of Neuroscience, vol. 20, no. 21. Society for Neuroscience, pp. 7896–7904, 2000.","ama":"Perroy J, Prezèau L, De Waard M, Shigemoto R, Bockaërt J, Fagni L. Selective blockade of P/Q-type calcium channels by the metabotropic glutamate receptor type 7 involves a phospholipase C pathway in neurons. Journal of Neuroscience. 2000;20(21):7896-7904. doi:10.1523/JNEUROSCI.20-21-07896.2000","chicago":"Perroy, Julie, Laurent Prezèau, Michel De Waard, Ryuichi Shigemoto, Joël Bockaërt, and Laurent Fagni. “Selective Blockade of P/Q-Type Calcium Channels by the Metabotropic Glutamate Receptor Type 7 Involves a Phospholipase C Pathway in Neurons.” Journal of Neuroscience. Society for Neuroscience, 2000. https://doi.org/10.1523/JNEUROSCI.20-21-07896.2000.","ista":"Perroy J, Prezèau L, De Waard M, Shigemoto R, Bockaërt J, Fagni L. 2000. Selective blockade of P/Q-type calcium channels by the metabotropic glutamate receptor type 7 involves a phospholipase C pathway in neurons. Journal of Neuroscience. 20(21), 7896–7904.","mla":"Perroy, Julie, et al. “Selective Blockade of P/Q-Type Calcium Channels by the Metabotropic Glutamate Receptor Type 7 Involves a Phospholipase C Pathway in Neurons.” Journal of Neuroscience, vol. 20, no. 21, Society for Neuroscience, 2000, pp. 7896–904, doi:10.1523/JNEUROSCI.20-21-07896.2000."},"article_type":"original","publication_identifier":{"issn":["0270-6474"]},"year":"2000","author":[{"last_name":"Perroy","full_name":"Perroy, Julie","first_name":"Julie"},{"first_name":"Laurent","last_name":"Prezèau","full_name":"Prezèau, Laurent"},{"last_name":"De Waard","full_name":"De Waard, Michel","first_name":"Michel"},{"last_name":"Shigemoto","full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Bockaërt","full_name":"Bockaërt, Joël","first_name":"Joël"},{"first_name":"Laurent","last_name":"Fagni","full_name":"Fagni, Laurent"}],"oa_version":"Published Version","doi":"10.1523/JNEUROSCI.20-21-07896.2000","day":"01","publisher":"Society for Neuroscience","main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772734/"}],"volume":20,"oa":1,"intvolume":" 20","acknowledgement":"This work was supported by Centre National de la Recherche Scientifique and grants from Association Française contre les Myopathies, Fondation pour la Recherche Médicale, Bayer (France), and Hoechst-Marrion-Roussel (FRHMR1/9702). We thank J. P. Pin and F. Ango for constructive discussion of this work. We also thank Dr. J. Saugstad (Atlanta, GA) for the rat mGluR7a cDNA, J. M. Sabatier (Marseille, France) for the synthesis of the 68 AA peptide, V. Homburger (Montpellier, France) for the anti-Gαo antibody, and B. Mouillac (Montpellier, France) for the anti-cMyc monoclonal antibody.","issue":"21","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","extern":"1","scopus_import":"1","month":"11","title":"Selective blockade of P/Q-type calcium channels by the metabotropic glutamate receptor type 7 involves a phospholipase C pathway in neurons","date_updated":"2023-05-03T09:48:17Z","article_processing_charge":"No","date_published":"2000-11-01T00:00:00Z","page":"7896 - 7904","publication":"Journal of Neuroscience","external_id":{"pmid":["11050109"]},"date_created":"2018-12-11T11:58:37Z","_id":"2602"},{"year":"2000","author":[{"first_name":"Hélène","last_name":"Boudin","full_name":"Boudin, Hélène"},{"first_name":"Andrew","last_name":"Doan","full_name":"Doan, Andrew"},{"last_name":"Xia","full_name":"Xia, Jun","first_name":"Jun"},{"first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444"},{"first_name":"Richard","full_name":"Huganir, Richard","last_name":"Huganir"},{"last_name":"Worley","full_name":"Worley, Paul","first_name":"Paul"},{"first_name":"Ann","full_name":"Craig, Ann","last_name":"Craig"}],"publication_identifier":{"issn":["0896-6273"]},"day":"01","publisher":"Elsevier","oa_version":"None","doi":"10.1016/S0896-6273(00)00127-6","quality_controlled":"1","status":"public","pmid":1,"language":[{"iso":"eng"}],"publist_id":"4295","publication_status":"published","abstract":[{"text":"Aggregation of neurotransmitter receptors at pre- and postsynaptic structures is crucial for efficient neuronal communication. In contrast to the wealth of information about postsynaptic specializations, little is known about the molecular organization of presynaptic membrane proteins. We show here that the metabotropic glutamate receptor mGluR7a, which localizes specifically to presynaptic active zones, interacts in vitro and in vivo with PICK1. Coexpression in heterologous systems induces coclustering dependent upon the extreme C terminus of mGluR7a and the PDZ domain of PICK1. mGluR7a and PICK1 localize to excitatory synapses in hippocampal neurons. Furthermore, whereas transfected mGluR7a clusters at presynaptic sites, mGluR7aΔ3 lacking the PICK1 binding site targets to axons but does not cluster. These results suggest that PICK1 is a component of the presynaptic machinery involved in mGlUR7a aggregation and in modulation of glutamate neurotransmission.","lang":"eng"}],"article_type":"original","citation":{"chicago":"Boudin, Hélène, Andrew Doan, Jun Xia, Ryuichi Shigemoto, Richard Huganir, Paul Worley, and Ann Craig. “Presynaptic Clustering of MGluR7a Requires the PICK1 PDZ Domain Binding Site.” Neuron. Elsevier, 2000. https://doi.org/10.1016/S0896-6273(00)00127-6.","ama":"Boudin H, Doan A, Xia J, et al. Presynaptic clustering of mGluR7a requires the PICK1 PDZ domain binding site. Neuron. 2000;28(2):485-497. doi:10.1016/S0896-6273(00)00127-6","mla":"Boudin, Hélène, et al. “Presynaptic Clustering of MGluR7a Requires the PICK1 PDZ Domain Binding Site.” Neuron, vol. 28, no. 2, Elsevier, 2000, pp. 485–97, doi:10.1016/S0896-6273(00)00127-6.","ista":"Boudin H, Doan A, Xia J, Shigemoto R, Huganir R, Worley P, Craig A. 2000. Presynaptic clustering of mGluR7a requires the PICK1 PDZ domain binding site. Neuron. 28(2), 485–497.","apa":"Boudin, H., Doan, A., Xia, J., Shigemoto, R., Huganir, R., Worley, P., & Craig, A. (2000). Presynaptic clustering of mGluR7a requires the PICK1 PDZ domain binding site. Neuron. Elsevier. https://doi.org/10.1016/S0896-6273(00)00127-6","short":"H. Boudin, A. Doan, J. Xia, R. Shigemoto, R. Huganir, P. Worley, A. Craig, Neuron 28 (2000) 485–497.","ieee":"H. Boudin et al., “Presynaptic clustering of mGluR7a requires the PICK1 PDZ domain binding site,” Neuron, vol. 28, no. 2. Elsevier, pp. 485–497, 2000."},"type":"journal_article","article_processing_charge":"No","date_published":"2000-11-01T00:00:00Z","month":"11","title":"Presynaptic clustering of mGluR7a requires the PICK1 PDZ domain binding site","date_updated":"2023-05-03T09:41:55Z","external_id":{"pmid":["11144358"]},"date_created":"2018-12-11T11:58:37Z","_id":"2603","page":"485 - 497","publication":"Neuron","intvolume":" 28","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","issue":"2","acknowledgement":"We thank Drs. S. Nakanishi, K. Moriyoshi, V. I. Gelfand, and P. J. Conn for gifts of cDNAs and antibodies, A. S. Serpinskaya and H. Wu for excellent preparation of neuron cultures, and H. J. Chung for help in immunoblots. This work was supported by the Pew Chari-table Trust and National Institutes of Health grants NS33184 and NS39286 (A. M. C.), K02MH01152 and NIDA DA10309 (P. W.), and a fellowship from IPSEN Foundation (H. B.). ","volume":28,"extern":"1","scopus_import":"1"},{"article_processing_charge":"No","date_published":"2000-01-01T00:00:00Z","title":"The kernel of Dirac operators on S3 and R3","date_updated":"2023-05-03T09:37:03Z","month":"01","_id":"2710","external_id":{"arxiv":["math-ph/0001036"]},"date_created":"2018-12-11T11:59:12Z","publication":"Differential Equations and Mathematical Physics","page":"111 - 119","intvolume":" 16","acknowledgement":"L. Erdös was supported by the N.S.F. grant DMS-9970323. J. P. Solovej was supported in parts by the EU TMR-grant FMRX-CT 96-0001 by MaPhySto — Centre for Mathematical Physics and Stochastics, funded by a grant from The Danish National Research Foundation and by a grant from the Danish Natural Science Research Council.","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","alternative_title":["AMS/IP Studies in Advanced Mathematics"],"volume":16,"extern":"1","year":"2000","author":[{"full_name":"Erdös, László","orcid":"0000-0001-5366-9603","last_name":"Erdös","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","first_name":"László"}],"publication_identifier":{"isbn":["9780821821572"]},"publisher":"American Mathematical Society","day":"01","doi":"10.1090/amsip/016","oa_version":"Preprint","arxiv":1,"quality_controlled":"1","publist_id":"4186","abstract":[{"lang":"eng","text":"In this paper we describe an intrinsically geometric way of producing magnetic fields on §3 and $\\R^3$ for which the corresponding Dirac operators have a non-trivial kernel. In many cases we are able to compute the dimension of the kernel. In particular we can give examples where the kernel has any given dimension. This generalizes the examples of Loss and Yau (Commun. Math. Phys. 104 (1986) 283-290)."}],"publication_status":"published","status":"public","language":[{"iso":"eng"}],"type":"book_chapter","citation":{"mla":"Erdös, László. “The Kernel of Dirac Operators on S3 and R3.” Differential Equations and Mathematical Physics, vol. 16, American Mathematical Society, 2000, pp. 111–19, doi:10.1090/amsip/016.","ista":"Erdös L. 2000.The kernel of Dirac operators on S3 and R3. In: Differential Equations and Mathematical Physics. AMS/IP Studies in Advanced Mathematics, vol. 16, 111–119.","chicago":"Erdös, László. “The Kernel of Dirac Operators on S3 and R3.” In Differential Equations and Mathematical Physics, 16:111–19. American Mathematical Society, 2000. https://doi.org/10.1090/amsip/016.","ama":"Erdös L. The kernel of Dirac operators on S3 and R3. In: Differential Equations and Mathematical Physics. Vol 16. American Mathematical Society; 2000:111-119. doi:10.1090/amsip/016","ieee":"L. Erdös, “The kernel of Dirac operators on S3 and R3,” in Differential Equations and Mathematical Physics, vol. 16, American Mathematical Society, 2000, pp. 111–119.","apa":"Erdös, L. (2000). The kernel of Dirac operators on S3 and R3. In Differential Equations and Mathematical Physics (Vol. 16, pp. 111–119). American Mathematical Society. https://doi.org/10.1090/amsip/016","short":"L. Erdös, in:, Differential Equations and Mathematical Physics, American Mathematical Society, 2000, pp. 111–119."}},{"publist_id":"4161","abstract":[{"lang":"eng","text":"We study the time evolution of a quantum particle in a Gaussian random environment. We show that in the weak coupling limit the Wigner distribution of the wave function converges to a solution of a linear Boltzmann equation globally in time. The Boltzmann collision kernel is given by the Born approximation of the quantum differential scattering cross section."}],"publication_status":"published","status":"public","language":[{"iso":"eng"}],"quality_controlled":"1","citation":{"short":"L. Erdös, H. Yau, Communications on Pure and Applied Mathematics 53 (2000) 667–735.","apa":"Erdös, L., & Yau, H. (2000). Linear Boltzmann equation as the weak coupling limit of a random Schrödinger equation. Communications on Pure and Applied Mathematics. Wiley-Blackwell. https://doi.org/10.1002/(SICI)1097-0312(200006)53:6&lt;667::AID-CPA1&gt;3.0.CO;2-5","ieee":"L. Erdös and H. Yau, “Linear Boltzmann equation as the weak coupling limit of a random Schrödinger equation,” Communications on Pure and Applied Mathematics, vol. 53, no. 6. Wiley-Blackwell, pp. 667–735, 2000.","ama":"Erdös L, Yau H. Linear Boltzmann equation as the weak coupling limit of a random Schrödinger equation. Communications on Pure and Applied Mathematics. 2000;53(6):667-735. doi:10.1002/(SICI)1097-0312(200006)53:6&lt;667::AID-CPA1&gt;3.0.CO;2-5","chicago":"Erdös, László, and Horng Yau. “Linear Boltzmann Equation as the Weak Coupling Limit of a Random Schrödinger Equation.” Communications on Pure and Applied Mathematics. Wiley-Blackwell, 2000. https://doi.org/10.1002/(SICI)1097-0312(200006)53:6&lt;667::AID-CPA1&gt;3.0.CO;2-5.","ista":"Erdös L, Yau H. 2000. Linear Boltzmann equation as the weak coupling limit of a random Schrödinger equation. Communications on Pure and Applied Mathematics. 53(6), 667–735.","mla":"Erdös, László, and Horng Yau. “Linear Boltzmann Equation as the Weak Coupling Limit of a Random Schrödinger Equation.” Communications on Pure and Applied Mathematics, vol. 53, no. 6, Wiley-Blackwell, 2000, pp. 667–735, doi:10.1002/(SICI)1097-0312(200006)53:6&lt;667::AID-CPA1&gt;3.0.CO;2-5."},"type":"journal_article","article_type":"original","publication_identifier":{"issn":["0010-3640"]},"year":"2000","author":[{"orcid":"0000-0001-5366-9603","full_name":"Erdös, László","last_name":"Erdös","first_name":"László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Horng","last_name":"Yau","full_name":"Yau, Horng"}],"doi":"10.1002/(SICI)1097-0312(200006)53:6<667::AID-CPA1>3.0.CO;2-5","arxiv":1,"oa_version":"Preprint","publisher":"Wiley-Blackwell","day":"01","volume":53,"intvolume":" 53","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","acknowledgement":"Partially supported by U.S. National Science Foundation grants DMS-9403462, 9703752. We would like to thank H. Spohn for his several comments and discussions on this project. Part of this work was done during the time when L. E. visited the Erwin Schrödinger Institute in Vienna and when both authors visited the Center of Theoretical Sciences in Taiwan. We thank them for the hospitality and the support of this work.","issue":"6","extern":"1","scopus_import":"1","title":"Linear Boltzmann equation as the weak coupling limit of a random Schrödinger equation","date_updated":"2023-05-03T09:09:04Z","month":"06","article_processing_charge":"No","date_published":"2000-06-01T00:00:00Z","publication":"Communications on Pure and Applied Mathematics","page":"667 - 735","_id":"2731","external_id":{"arxiv":["math-ph/9901020"]},"date_created":"2018-12-11T11:59:18Z"},{"scopus_import":"1","extern":"1","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","acknowledgement":"The authors are indebted to H. Spohn for discussions. F.C. and L.E. were partially supported by the Erwin Schrödinger Institute in Vienna (Austria) during their visit, and they thank this institution for its hospitality. This work was supported by the TMR-Network ``Asymptotic Methods in Kinetic Theory'' number ERB FMBX CT97 0157 (F.C., F.F., and P.A.M.) and by NSF Grant DMS-9970323 (L.E.).","issue":"3-4","intvolume":" 100","volume":100,"_id":"2732","date_created":"2018-12-11T11:59:18Z","publication":"Journal of Statistical Physics","page":"543 - 601","date_published":"2000-01-01T00:00:00Z","article_processing_charge":"No","date_updated":"2023-05-03T09:02:11Z","title":"Fokker-Planck equations as scaling limits of reversible quantum systems","month":"01","article_type":"original","type":"journal_article","citation":{"ama":"Castella F, Erdös L, Frommlet F, Markowich P. Fokker-Planck equations as scaling limits of reversible quantum systems. Journal of Statistical Physics. 2000;100(3-4):543-601. doi:10.1023/A:1018667323830","chicago":"Castella, François, László Erdös, Florian Frommlet, and Peter Markowich. “Fokker-Planck Equations as Scaling Limits of Reversible Quantum Systems.” Journal of Statistical Physics. Springer, 2000. https://doi.org/10.1023/A:1018667323830.","mla":"Castella, François, et al. “Fokker-Planck Equations as Scaling Limits of Reversible Quantum Systems.” Journal of Statistical Physics, vol. 100, no. 3–4, Springer, 2000, pp. 543–601, doi:10.1023/A:1018667323830.","ista":"Castella F, Erdös L, Frommlet F, Markowich P. 2000. Fokker-Planck equations as scaling limits of reversible quantum systems. Journal of Statistical Physics. 100(3–4), 543–601.","apa":"Castella, F., Erdös, L., Frommlet, F., & Markowich, P. (2000). Fokker-Planck equations as scaling limits of reversible quantum systems. Journal of Statistical Physics. Springer. https://doi.org/10.1023/A:1018667323830","short":"F. Castella, L. Erdös, F. Frommlet, P. Markowich, Journal of Statistical Physics 100 (2000) 543–601.","ieee":"F. Castella, L. Erdös, F. Frommlet, and P. Markowich, “Fokker-Planck equations as scaling limits of reversible quantum systems,” Journal of Statistical Physics, vol. 100, no. 3–4. Springer, pp. 543–601, 2000."},"quality_controlled":"1","publication_status":"published","abstract":[{"text":"We consider a quantum particle moving in a harmonic exterior potential and linearly coupled to a heat bath of quantum oscillators. Caldeira and Leggett derived the Fokker Planck equation with friction for the Wigner distribution of the particle in the large-temperature limit: however, their (nonrigorous) derivation was not free of criticism, especially since the limiting equation is not of Lindblad form. In this paper we recover the correct form of their result in a rigorous way. We also point out that the source of the diffusion is physically restrictive under this scaling. We investigate the model at a fixed temperature and in the large-time limit, where the origin of the diffusion is a cumulative effect of many resonant collisions. We obtain a heat equation with a friction term for the radial process in phase space and we prove the Einstein relation in this case.","lang":"eng"}],"publist_id":"4160","language":[{"iso":"eng"}],"status":"public","publisher":"Springer","day":"01","doi":"10.1023/A:1018667323830","oa_version":"None","author":[{"last_name":"Castella","full_name":"Castella, François","first_name":"François"},{"last_name":"Erdös","full_name":"Erdös, László","orcid":"0000-0001-5366-9603","first_name":"László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Frommlet","full_name":"Frommlet, Florian","first_name":"Florian"},{"full_name":"Markowich, Peter","last_name":"Markowich","first_name":"Peter"}],"year":"2000","publication_identifier":{"issn":["0022-4715"]}},{"_id":"2733","date_created":"2018-12-11T11:59:19Z","publication":"Annales de l'Institut Fourier","page":"891 - 907","date_published":"2000-01-01T00:00:00Z","article_processing_charge":"No","title":"Diamagnetic behavior of sums Dirichlet eigenvalues","date_updated":"2023-05-03T08:56:17Z","month":"01","scopus_import":"1","extern":"1","issue":"3","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","intvolume":" 50","volume":50,"publisher":"Association des Annales de l'Institut Fourier","day":"01","doi":"10.5802/aif.1777","oa_version":"None","author":[{"id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","first_name":"László","full_name":"Erdös, László","orcid":"0000-0001-5366-9603","last_name":"Erdös"},{"full_name":"Loss, Michael","last_name":"Loss","first_name":"Michael"},{"full_name":"Vougalter, Vitali","last_name":"Vougalter","first_name":"Vitali"}],"year":"2000","publication_identifier":{"issn":["0373-0956"]},"article_type":"original","citation":{"mla":"Erdös, László, et al. “Diamagnetic Behavior of Sums Dirichlet Eigenvalues.” Annales de l’Institut Fourier, vol. 50, no. 3, Association des Annales de l’Institut Fourier, 2000, pp. 891–907, doi:10.5802/aif.1777.","ista":"Erdös L, Loss M, Vougalter V. 2000. Diamagnetic behavior of sums Dirichlet eigenvalues. Annales de l’Institut Fourier. 50(3), 891–907.","chicago":"Erdös, László, Michael Loss, and Vitali Vougalter. “Diamagnetic Behavior of Sums Dirichlet Eigenvalues.” Annales de l’Institut Fourier. Association des Annales de l’Institut Fourier, 2000. https://doi.org/10.5802/aif.1777.","ama":"Erdös L, Loss M, Vougalter V. Diamagnetic behavior of sums Dirichlet eigenvalues. Annales de l’Institut Fourier. 2000;50(3):891-907. doi:10.5802/aif.1777","ieee":"L. Erdös, M. Loss, and V. Vougalter, “Diamagnetic behavior of sums Dirichlet eigenvalues,” Annales de l’Institut Fourier, vol. 50, no. 3. Association des Annales de l’Institut Fourier, pp. 891–907, 2000.","apa":"Erdös, L., Loss, M., & Vougalter, V. (2000). Diamagnetic behavior of sums Dirichlet eigenvalues. Annales de l’Institut Fourier. Association des Annales de l’Institut Fourier. https://doi.org/10.5802/aif.1777","short":"L. Erdös, M. Loss, V. Vougalter, Annales de l’Institut Fourier 50 (2000) 891–907."},"type":"journal_article","quality_controlled":"1","abstract":[{"lang":"eng","text":"The Li-Yau semiclassical lower bound for the sum of the first N eigenvalues of the Dirichlet–Laplacian is extended to Dirichlet–Laplacians with constant magnetic fields. Our method involves a new diamagnetic inequality for constant magnetic fields."}],"publication_status":"published","publist_id":"4159","language":[{"iso":"eng"}],"status":"public"},{"oa_version":"Published Version","doi":"10.1074/jbc.M000032200 ","day":"09","publisher":"American Society for Biochemistry and Molecular Biology","publication_identifier":{"issn":["0021-9258"]},"year":"2000","author":[{"first_name":"Jae","last_name":"Hwang","full_name":"Hwang, Jae"},{"last_name":"Siekhaus","orcid":"0000-0001-8323-8353","full_name":"Siekhaus, Daria E","id":"3D224B9E-F248-11E8-B48F-1D18A9856A87","first_name":"Daria E"},{"last_name":"Fuller","full_name":"Fuller, Robert","first_name":"Robert"},{"last_name":"Taghert","full_name":"Taghert, Paul","first_name":"Paul"},{"full_name":"Lindberg, Iris","last_name":"Lindberg","first_name":"Iris"}],"type":"journal_article","citation":{"ista":"Hwang J, Siekhaus DE, Fuller R, Taghert P, Lindberg I. 2000. Interaction of Drosophila melanogaster prohormone convertase 2 and 7B2: Insect cell specific processing and secretion. Journal of Biological Chemistry. 275(23), 17886–17893.","mla":"Hwang, Jae, et al. “Interaction of Drosophila Melanogaster Prohormone Convertase 2 and 7B2: Insect Cell Specific Processing and Secretion.” Journal of Biological Chemistry, vol. 275, no. 23, American Society for Biochemistry and Molecular Biology, 2000, pp. 17886–93, doi:10.1074/jbc.M000032200 .","chicago":"Hwang, Jae, Daria E Siekhaus, Robert Fuller, Paul Taghert, and Iris Lindberg. “Interaction of Drosophila Melanogaster Prohormone Convertase 2 and 7B2: Insect Cell Specific Processing and Secretion.” Journal of Biological Chemistry. American Society for Biochemistry and Molecular Biology, 2000. https://doi.org/10.1074/jbc.M000032200 .","ama":"Hwang J, Siekhaus DE, Fuller R, Taghert P, Lindberg I. Interaction of Drosophila melanogaster prohormone convertase 2 and 7B2: Insect cell specific processing and secretion. Journal of Biological Chemistry. 2000;275(23):17886-17893. doi:10.1074/jbc.M000032200 ","ieee":"J. Hwang, D. E. Siekhaus, R. Fuller, P. Taghert, and I. Lindberg, “Interaction of Drosophila melanogaster prohormone convertase 2 and 7B2: Insect cell specific processing and secretion,” Journal of Biological Chemistry, vol. 275, no. 23. American Society for Biochemistry and Molecular Biology, pp. 17886–17893, 2000.","short":"J. Hwang, D.E. Siekhaus, R. Fuller, P. Taghert, I. Lindberg, Journal of Biological Chemistry 275 (2000) 17886–17893.","apa":"Hwang, J., Siekhaus, D. E., Fuller, R., Taghert, P., & Lindberg, I. (2000). Interaction of Drosophila melanogaster prohormone convertase 2 and 7B2: Insect cell specific processing and secretion. Journal of Biological Chemistry. American Society for Biochemistry and Molecular Biology. https://doi.org/10.1074/jbc.M000032200 "},"article_type":"original","status":"public","pmid":1,"language":[{"iso":"eng"}],"publist_id":"3546","publication_status":"published","abstract":[{"lang":"eng","text":"The prohormone convertases (PCs) are an evolutionarily ancient group of proteases required for the maturation of neuropeptide and peptide hormone precursors. In Drosophila melanogaster, the homolog of prohormone convertase 2, dPC2 (amontillado), is required for normal hatching behavior, and immunoblotting data indicate that flies express 80- and 75-kDa forms of this protein. Because mouse PC2 (mPC2) requires 7B2, a helper protein for productive maturation, we searched the fly data base for the 7B2 signature motif PPNPCP and identified an expressed sequence tag clone encoding the entire open reading frame for this protein. dPC2 and d7B2 cDNAs were subcloned into expression vectors for transfection into HEK-293 cells; mPC2 and rat 7B2 were used as controls. Although active mPC2 was detected in medium in the presence of either d7B2 or r7B2, dPC2 showed no proteolytic activity upon coexpression of either d7B2 or r7B2. Labeling experiments showed that dPC2 was synthesized but not secreted from HEK-293 cells. However, when dPC2 and either d7B2 or r7B2 were coexpressed in Drosophila S2 cells, abundant immunoreactive dPC2 was secreted into the medium, coincident with the appearance of PC2 activity. Expression and secretion of dPC2 enzyme activity thus appears to require insect cell-specific posttranslational processing events. The significant differences in the cell biology of the insect and mammalian enzymes, with 7B2 absolutely required for secretion of dPC2 and zymogen conversion occurring intracellularly in the case of dPC2 but not mPC2, support the idea that the Drosophila enzyme has specific requirements for maturation and secretion that can be met only in insect cells."}],"quality_controlled":"1","page":"17886 - 17893","publication":"Journal of Biological Chemistry","external_id":{"pmid":["10749852"]},"date_created":"2018-12-11T12:01:40Z","_id":"3149","month":"06","date_updated":"2023-05-03T08:47:13Z","title":"Interaction of Drosophila melanogaster prohormone convertase 2 and 7B2: Insect cell specific processing and secretion","article_processing_charge":"No","date_published":"2000-06-09T00:00:00Z","extern":"1","scopus_import":"1","main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/S0021925819833215?via%3Dihub","open_access":"1"}],"volume":275,"intvolume":" 275","oa":1,"acknowledgement":"This work was supported by National Institutes of Health Grants DK49703 (to I. L.), NS21749 (to P. H. T.), and GM39697 (to R. S. F.). The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. 10749852. We thank members of the Lindberg laboratory and Laurent Muller for helpful comments, Bin Tu for construction of the C. elegans PC2 expression vector, and Joelle Finley for assistance with cell culture.","issue":"23","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17"},{"article_type":"original","type":"journal_article","citation":{"ama":"Kraushaar U, Jonas PM. Efficacy and stability of quantal GABA release at a hippocampal interneuron-principal neuron synapse. Journal of Neuroscience. 2000;20(15):5594-5607. doi:10.1523/JNEUROSCI.20-15-05594.2000","chicago":"Kraushaar, Udo, and Peter M Jonas. “Efficacy and Stability of Quantal GABA Release at a Hippocampal Interneuron-Principal Neuron Synapse.” Journal of Neuroscience. Society for Neuroscience, 2000. https://doi.org/10.1523/JNEUROSCI.20-15-05594.2000.","ista":"Kraushaar U, Jonas PM. 2000. Efficacy and stability of quantal GABA release at a hippocampal interneuron-principal neuron synapse. Journal of Neuroscience. 20(15), 5594–5607.","mla":"Kraushaar, Udo, and Peter M. Jonas. “Efficacy and Stability of Quantal GABA Release at a Hippocampal Interneuron-Principal Neuron Synapse.” Journal of Neuroscience, vol. 20, no. 15, Society for Neuroscience, 2000, pp. 5594–607, doi:10.1523/JNEUROSCI.20-15-05594.2000.","short":"U. Kraushaar, P.M. Jonas, Journal of Neuroscience 20 (2000) 5594–5607.","apa":"Kraushaar, U., & Jonas, P. M. (2000). Efficacy and stability of quantal GABA release at a hippocampal interneuron-principal neuron synapse. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.20-15-05594.2000","ieee":"U. Kraushaar and P. M. Jonas, “Efficacy and stability of quantal GABA release at a hippocampal interneuron-principal neuron synapse,” Journal of Neuroscience, vol. 20, no. 15. Society for Neuroscience, pp. 5594–5607, 2000."},"quality_controlled":"1","pmid":1,"status":"public","language":[{"iso":"eng"}],"publist_id":"2898","abstract":[{"text":"We have examined factors that determine the strength and dynamics of GABAergic synapses between interneurons [dentate gyrus basket cells (BCs)] and principal neurons [dentate gyrus granule cells (GCs)] using paired recordings in rat hippocampal slices at 34°C. Unitary IPSCs recorded from BC–GC pairs in high intracellular Cl− concentration showed a fast rise and a biexponential decay, with mean time constants of 2 and 9 msec. The mean quantal conductance change, determined directly at reduced extracellular Ca2+/Mg2+concentration ratios, was 1.7 nS. Quantal release at the BC–GC synapse occurred with short delay and was highly synchronized. Analysis of IPSC peak amplitudes and numbers of failures by multiple probability compound binomial analysis indicated that synaptic transmission at the BC–GC synapse involves three to seven release sites, each of which releases transmitter with high probability (∼0.5 in 2 mMCa2+/1 mM Mg2+). Unitary BC–GC IPSCs showed paired-pulse depression (PPD); maximal depression, measured for 10 msec intervals, was 37%, and recovery from depression occurred with a time constant of 2 sec. Paired-pulse depression was mainly presynaptic in origin but appeared to be independent of previous release. Synaptic transmission at the BC–GC synapse showed frequency-dependent depression, with half-maximal decrease at 5 Hz after a series of 1000 presynaptic action potentials. The relative stability of transmission at the BC–GC synapse is consistent with a model in which an activity-dependent gating mechanism reduces release probability and thereby prevents depletion of the releasable pool of synaptic vesicles. Thus several mechanisms converge on the generation of powerful and sustained transmission at interneuron–principal neuron synapses in hippocampal circuits.","lang":"eng"}],"publication_status":"published","day":"01","publisher":"Society for Neuroscience","oa_version":"Published Version","doi":"10.1523/JNEUROSCI.20-15-05594.2000","year":"2000","author":[{"first_name":"Udo","full_name":"Kraushaar, Udo","last_name":"Kraushaar"},{"first_name":"Peter M","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5001-4804","full_name":"Jonas, Peter M","last_name":"Jonas"}],"publication_identifier":{"issn":["0270-6474"]},"extern":"1","scopus_import":"1","intvolume":" 20","oa":1,"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","issue":"15","acknowledgement":"This work was supported by grants from the Deutsche Forschungsgemeinschaft (SFB 505/C5) and the Human Frontiers Science Program Organization (RG0017/1998-B) to P.J. Novartis generously provided CGP55845A. We thank Drs. J. Bischofberger, F. A. Edwards, J. R. P. Geiger, M. V. Jones, M. Martina, and A. Roth for critically reading this manuscript. We also thank A. Blomenkamp for technical assistance.","main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772523/"}],"volume":20,"external_id":{"pmid":["10908596"]},"date_created":"2018-12-11T12:03:36Z","_id":"3489","page":"5594 - 5607","publication":"Journal of Neuroscience","article_processing_charge":"No","date_published":"2000-08-01T00:00:00Z","month":"08","title":"Efficacy and stability of quantal GABA release at a hippocampal interneuron-principal neuron synapse","date_updated":"2023-05-03T08:18:39Z"}]