[{"month":"09","title":"Cryo-electron crystallography of two sub-complexes of bovine complex I reveals the relationship between the membrane and peripheral arms","date_updated":"2023-05-04T13:23:03Z","date_published":"2000-09-15T00:00:00Z","article_processing_charge":"No","page":"455 - 464","publication":"Journal of Molecular Biology","date_created":"2018-12-11T11:54:55Z","external_id":{"pmid":["10970745"]},"_id":"1957","volume":302,"acknowledgement":"We thank Drs I. M. Fearnley and S. Y. Peak-Chew for performing peptide mass mapping. We also thank Drs R. Henderson and G. F. X. Schertler for advice on image processing and for valuable discussions.","issue":"2","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","intvolume":"       302","scopus_import":"1","extern":"1","publication_identifier":{"issn":["0022-2836"]},"author":[{"orcid":"0000-0002-0977-7989","full_name":"Sazanov, Leonid A","last_name":"Sazanov","first_name":"Leonid A","id":"338D39FE-F248-11E8-B48F-1D18A9856A87"},{"first_name":"John","last_name":"Walker","full_name":"Walker, John"}],"year":"2000","oa_version":"None","doi":"10.1006/jmbi.2000.4079","day":"15","publisher":"Elsevier","language":[{"iso":"eng"}],"pmid":1,"status":"public","abstract":[{"lang":"eng","text":"NADH:ubiquinone oxidoreductase (complex I) is the first and largest enzyme of the mitochondrial respiratory chain. The low-resolution structure of the complex is known from electron microscopy studies. The general shape of the complex is in the form of an L, with one arm in the membrane and the other peripheral. We have purified complex I from beef heart mitochondria and reconstituted the enzyme into lipid bilayers. Under different conditions, several two-dimensional crystal forms were obtained. Crystals belonging to space groups p2221 and c12 (unit cell 488 Å x 79 Å) were obtained at 22°C and contained only the membrane fragment of complex I similar to hydrophobic subcomplex Iβ but lacking the ND5 subunit. A crystal form with larger unit cell (534 Å x 81 Å, space group c12) produced at 4°C contained both the peripheral and membrane arms of the enzyme, except that ND5 was missing. Projection maps from frozen hydrated samples were calculated for all crystal forms. By comparing two different c12 crystal forms, extra electron density in the projection map of large crystal form was assigned to the peripheral arm of the enzyme. One of the features of the map is a deep, channel-like, cleft next to peripheral arm. Comparison with available structures of the intact enzyme indicates that large hydrophobic subunit ND5 is situated at the distal end of the membrane domain. Possible locations of sub-unit ND4 and of other subunits in the membrane domain are proposed. Implications of our findings for the mechanism of proton pumping by complex I are discussed. (C) 2000 Academic Press."}],"publication_status":"published","publist_id":"5126","quality_controlled":"1","citation":{"ieee":"L. A. Sazanov and J. Walker, “Cryo-electron crystallography of two sub-complexes of bovine complex I reveals the relationship between the membrane and peripheral arms,” <i>Journal of Molecular Biology</i>, vol. 302, no. 2. Elsevier, pp. 455–464, 2000.","short":"L.A. Sazanov, J. Walker, Journal of Molecular Biology 302 (2000) 455–464.","apa":"Sazanov, L. A., &#38; Walker, J. (2000). Cryo-electron crystallography of two sub-complexes of bovine complex I reveals the relationship between the membrane and peripheral arms. <i>Journal of Molecular Biology</i>. Elsevier. <a href=\"https://doi.org/10.1006/jmbi.2000.4079\">https://doi.org/10.1006/jmbi.2000.4079</a>","mla":"Sazanov, Leonid A., and John Walker. “Cryo-Electron Crystallography of Two Sub-Complexes of Bovine Complex I Reveals the Relationship between the Membrane and Peripheral Arms.” <i>Journal of Molecular Biology</i>, vol. 302, no. 2, Elsevier, 2000, pp. 455–64, doi:<a href=\"https://doi.org/10.1006/jmbi.2000.4079\">10.1006/jmbi.2000.4079</a>.","ista":"Sazanov LA, Walker J. 2000. Cryo-electron crystallography of two sub-complexes of bovine complex I reveals the relationship between the membrane and peripheral arms. Journal of Molecular Biology. 302(2), 455–464.","chicago":"Sazanov, Leonid A, and John Walker. “Cryo-Electron Crystallography of Two Sub-Complexes of Bovine Complex I Reveals the Relationship between the Membrane and Peripheral Arms.” <i>Journal of Molecular Biology</i>. Elsevier, 2000. <a href=\"https://doi.org/10.1006/jmbi.2000.4079\">https://doi.org/10.1006/jmbi.2000.4079</a>.","ama":"Sazanov LA, Walker J. Cryo-electron crystallography of two sub-complexes of bovine complex I reveals the relationship between the membrane and peripheral arms. <i>Journal of Molecular Biology</i>. 2000;302(2):455-464. doi:<a href=\"https://doi.org/10.1006/jmbi.2000.4079\">10.1006/jmbi.2000.4079</a>"},"type":"journal_article","article_type":"original"},{"date_published":"2000-05-24T00:00:00Z","article_processing_charge":"No","date_updated":"2023-05-04T14:14:53Z","title":"Resolution of the membrane domain of bovine complex I into subcomplexes: implications for the structural organization of the enzyme","month":"05","_id":"1958","date_created":"2018-12-11T11:54:55Z","external_id":{"pmid":["10852722"]},"publication":"Biochemistry","page":"7229 - 7235","issue":"24","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","intvolume":"        39","volume":39,"scopus_import":"1","extern":"1","author":[{"id":"338D39FE-F248-11E8-B48F-1D18A9856A87","first_name":"Leonid A","last_name":"Sazanov","orcid":"0000-0002-0977-7989","full_name":"Sazanov, Leonid A"},{"full_name":"Peak Chew, Sew","last_name":"Peak Chew","first_name":"Sew"},{"full_name":"Fearnley, Ian","last_name":"Fearnley","first_name":"Ian"},{"first_name":"John","full_name":"Walker, John","last_name":"Walker"}],"year":"2000","publication_identifier":{"issn":["0006-2960"]},"publisher":"ACS","day":"24","doi":"10.1021/bi000335t","oa_version":"None","quality_controlled":"1","publication_status":"published","abstract":[{"lang":"eng","text":"\r\nComplex I (NADH:ubiquinone oxidoreductase) purified from bovine heart mitochondria was treated with the detergent N,N-dimethyldodecylamine N-oxide (LDAO). The enzyme dissociated into two known subcomplexes, Iα and Iβ, containing mostly hydrophilic and hydrophobic subunits, and a previously undetected fragment referred to as Iγ. Subcomplex Iγ contains the hydrophobic subunits ND1, ND2, ND3, and ND4L which are encoded in the mitochondrial genome, and the nuclear-encoded subunit KFYL. During size- exclusion chromatography in the presence of LDAO, subcomplex Iα lost several subunits and formed another characterized subcomplex known as Iλ. Similarly, subcomplex Iβ dissociated into two smaller subcomplexes, one of which contains the hydrophobic subunits ND4 and ND5; subcomplex Iγ released a fragment containing ND1 and ND2. These results suggest that in the intact complex subunits ND1 and ND2 are likely to be in a different region of the membrane domain than subunits ND4 and ND5. The compositions of the various subcomplexes and fragments of complex I provide an organization of the subunits of the enzyme in the framework of the known low resolution structure of the enzyme."}],"publist_id":"5127","language":[{"iso":"eng"}],"status":"public","pmid":1,"article_type":"original","type":"journal_article","citation":{"ieee":"L. A. Sazanov, S. Peak Chew, I. Fearnley, and J. Walker, “Resolution of the membrane domain of bovine complex I into subcomplexes: implications for the structural organization of the enzyme,” <i>Biochemistry</i>, vol. 39, no. 24. ACS, pp. 7229–7235, 2000.","short":"L.A. Sazanov, S. Peak Chew, I. Fearnley, J. Walker, Biochemistry 39 (2000) 7229–7235.","apa":"Sazanov, L. A., Peak Chew, S., Fearnley, I., &#38; Walker, J. (2000). Resolution of the membrane domain of bovine complex I into subcomplexes: implications for the structural organization of the enzyme. <i>Biochemistry</i>. ACS. <a href=\"https://doi.org/10.1021/bi000335t\">https://doi.org/10.1021/bi000335t</a>","mla":"Sazanov, Leonid A., et al. “Resolution of the Membrane Domain of Bovine Complex I into Subcomplexes: Implications for the Structural Organization of the Enzyme.” <i>Biochemistry</i>, vol. 39, no. 24, ACS, 2000, pp. 7229–35, doi:<a href=\"https://doi.org/10.1021/bi000335t\">10.1021/bi000335t</a>.","ista":"Sazanov LA, Peak Chew S, Fearnley I, Walker J. 2000. Resolution of the membrane domain of bovine complex I into subcomplexes: implications for the structural organization of the enzyme. Biochemistry. 39(24), 7229–7235.","ama":"Sazanov LA, Peak Chew S, Fearnley I, Walker J. Resolution of the membrane domain of bovine complex I into subcomplexes: implications for the structural organization of the enzyme. <i>Biochemistry</i>. 2000;39(24):7229-7235. doi:<a href=\"https://doi.org/10.1021/bi000335t\">10.1021/bi000335t</a>","chicago":"Sazanov, Leonid A, Sew Peak Chew, Ian Fearnley, and John Walker. “Resolution of the Membrane Domain of Bovine Complex I into Subcomplexes: Implications for the Structural Organization of the Enzyme.” <i>Biochemistry</i>. ACS, 2000. <a href=\"https://doi.org/10.1021/bi000335t\">https://doi.org/10.1021/bi000335t</a>."}},{"date_published":"2000-12-01T00:00:00Z","article_processing_charge":"No","keyword":["Organic Chemistry"],"date_updated":"2023-08-02T07:54:46Z","title":"Simple synthesis of 2-substituted Tetrahydrofuran-3-carbonitriles","month":"12","_id":"13437","date_created":"2023-08-01T10:39:48Z","publication":"Synlett","page":"1773-1774","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","issue":"12","intvolume":"      2000","volume":2000,"scopus_import":"1","extern":"1","author":[{"first_name":"Mieczysław","full_name":"Macogonkosza, Mieczysław","last_name":"Macogonkosza"},{"last_name":"Przyborowski","full_name":"Przyborowski, Jacek","first_name":"Jacek"},{"last_name":"Klajn","full_name":"Klajn, Rafal","first_name":"Rafal","id":"8e84690e-1e48-11ed-a02b-a1e6fb8bb53b"},{"full_name":"Kwast, Andrzej","last_name":"Kwast","first_name":"Andrzej"}],"year":"2000","publication_identifier":{"issn":["0936-5214"],"eissn":["1437-2096"]},"publisher":"Georg Thieme Verlag","day":"01","doi":"10.1055/s-2000-8670","oa_version":"None","quality_controlled":"1","publication_status":"published","abstract":[{"text":"Liquid/liquid Phase Transfer Catalysis (PTC) reaction of 4-chlorobutyronitrile with nonenolisable aldehydes leads via an addition-cyclisation reaction sequence to derivatives of tetrahydrofuran-3-carbonitrile.","lang":"eng"}],"language":[{"iso":"eng"}],"status":"public","article_type":"letter_note","type":"journal_article","citation":{"chicago":"Macogonkosza, Mieczysław, Jacek Przyborowski, Rafal Klajn, and Andrzej Kwast. “Simple Synthesis of 2-Substituted Tetrahydrofuran-3-Carbonitriles.” <i>Synlett</i>. Georg Thieme Verlag, 2000. <a href=\"https://doi.org/10.1055/s-2000-8670\">https://doi.org/10.1055/s-2000-8670</a>.","ama":"Macogonkosza M, Przyborowski J, Klajn R, Kwast A. Simple synthesis of 2-substituted Tetrahydrofuran-3-carbonitriles. <i>Synlett</i>. 2000;2000(12):1773-1774. doi:<a href=\"https://doi.org/10.1055/s-2000-8670\">10.1055/s-2000-8670</a>","mla":"Macogonkosza, Mieczysław, et al. “Simple Synthesis of 2-Substituted Tetrahydrofuran-3-Carbonitriles.” <i>Synlett</i>, vol. 2000, no. 12, Georg Thieme Verlag, 2000, pp. 1773–74, doi:<a href=\"https://doi.org/10.1055/s-2000-8670\">10.1055/s-2000-8670</a>.","ista":"Macogonkosza M, Przyborowski J, Klajn R, Kwast A. 2000. Simple synthesis of 2-substituted Tetrahydrofuran-3-carbonitriles. Synlett. 2000(12), 1773–1774.","short":"M. Macogonkosza, J. Przyborowski, R. Klajn, A. Kwast, Synlett 2000 (2000) 1773–1774.","apa":"Macogonkosza, M., Przyborowski, J., Klajn, R., &#38; Kwast, A. (2000). Simple synthesis of 2-substituted Tetrahydrofuran-3-carbonitriles. <i>Synlett</i>. Georg Thieme Verlag. <a href=\"https://doi.org/10.1055/s-2000-8670\">https://doi.org/10.1055/s-2000-8670</a>","ieee":"M. Macogonkosza, J. Przyborowski, R. Klajn, and A. Kwast, “Simple synthesis of 2-substituted Tetrahydrofuran-3-carbonitriles,” <i>Synlett</i>, vol. 2000, no. 12. Georg Thieme Verlag, pp. 1773–1774, 2000."}},{"article_processing_charge":"No","date_published":"2000-06-01T00:00:00Z","title":"Inscribing cubes and covering by rhombic dodecahedra via equivariant topology","date_updated":"2023-05-08T08:56:46Z","month":"06","_id":"1455","external_id":{"arxiv":["math/9906066"]},"date_created":"2018-12-11T11:52:07Z","publication":"Mathematika","page":"371 - 397","oa":1,"intvolume":"        47","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","acknowledgement":"The research of the first author was partially supported by Trinity College, Cambridge, and that of all the authors by grants 23444, T-030012 and A 046/96, respectively, from the Hungarian National Foundation for Scientific Research.","issue":"1-2","main_file_link":[{"url":"http://arxiv.org/abs/math/9906066","open_access":"1"}],"volume":47,"extern":"1","scopus_import":"1","year":"2000","author":[{"first_name":"Tamas","id":"4A0666D8-F248-11E8-B48F-1D18A9856A87","last_name":"Hausel","full_name":"Hausel, Tamas"},{"last_name":"Makai","full_name":"Makai, Endre","first_name":"Endre"},{"full_name":"Szücs, András","last_name":"Szücs","first_name":"András"}],"publication_identifier":{"issn":["0025-5793"]},"publisher":"University College London","day":"01","doi":"10.1112/S0025579300015965","oa_version":"Preprint","arxiv":1,"quality_controlled":"1","publist_id":"5745","publication_status":"published","abstract":[{"lang":"eng","text":"First, a special case of Knaster's problem is proved implying that each symmetric convex body in ℝ3 admits an inscribed cube. It is deduced from a theorem in equivariant topology, which says that there is no S4 - equivariant map from SO(3) to S2, where S4 acts on SO(3) on the right as the rotation group of the cube, and on S2 on the right as the symmetry group of the regular tetrahedron. Some generalizations are also given. Second, it is shown how the above non-existence theorem yields Makeev's conjecture in ℝ3 that each set in ℝ3 of diameter 1 can be covered by a rhombic dodecahedron, which has distance 1 between its opposite faces. This reveals an unexpected connection between inscribing cubes into symmetric bodies and covering sets by rhombic dodecahedra. Finally, a possible application of our second theorem to the Borsuk problem in ℝ3 is pointed out."}],"status":"public","language":[{"iso":"eng"}],"article_type":"original","citation":{"apa":"Hausel, T., Makai, E., &#38; Szücs, A. (2000). Inscribing cubes and covering by rhombic dodecahedra via equivariant topology. <i>Mathematika</i>. University College London. <a href=\"https://doi.org/10.1112/S0025579300015965\">https://doi.org/10.1112/S0025579300015965</a>","short":"T. Hausel, E. Makai, A. Szücs, Mathematika 47 (2000) 371–397.","ieee":"T. Hausel, E. Makai, and A. Szücs, “Inscribing cubes and covering by rhombic dodecahedra via equivariant topology,” <i>Mathematika</i>, vol. 47, no. 1–2. University College London, pp. 371–397, 2000.","chicago":"Hausel, Tamás, Endre Makai, and András Szücs. “Inscribing Cubes and Covering by Rhombic Dodecahedra via Equivariant Topology.” <i>Mathematika</i>. University College London, 2000. <a href=\"https://doi.org/10.1112/S0025579300015965\">https://doi.org/10.1112/S0025579300015965</a>.","ama":"Hausel T, Makai E, Szücs A. Inscribing cubes and covering by rhombic dodecahedra via equivariant topology. <i>Mathematika</i>. 2000;47(1-2):371-397. doi:<a href=\"https://doi.org/10.1112/S0025579300015965\">10.1112/S0025579300015965</a>","mla":"Hausel, Tamás, et al. “Inscribing Cubes and Covering by Rhombic Dodecahedra via Equivariant Topology.” <i>Mathematika</i>, vol. 47, no. 1–2, University College London, 2000, pp. 371–97, doi:<a href=\"https://doi.org/10.1112/S0025579300015965\">10.1112/S0025579300015965</a>.","ista":"Hausel T, Makai E, Szücs A. 2000. Inscribing cubes and covering by rhombic dodecahedra via equivariant topology. Mathematika. 47(1–2), 371–397."},"type":"journal_article"},{"article_type":"original","type":"journal_article","citation":{"mla":"Hetzer, Martin, and Iain W. Mattaj. “An Atp-Dependent, Ran-Independent Mechanism for Nuclear Import of the U1a and U2b′′ Spliceosome Proteins.” <i>Journal of Cell Biology</i>, vol. 148, no. 2, Rockefeller University Press, 2000, pp. 293–304, doi:<a href=\"https://doi.org/10.1083/jcb.148.2.293\">10.1083/jcb.148.2.293</a>.","ista":"Hetzer M, Mattaj IW. 2000. An Atp-dependent, Ran-independent mechanism for nuclear import of the U1a and U2b′′ spliceosome proteins. Journal of Cell Biology. 148(2), 293–304.","ama":"Hetzer M, Mattaj IW. An Atp-dependent, Ran-independent mechanism for nuclear import of the U1a and U2b′′ spliceosome proteins. <i>Journal of Cell Biology</i>. 2000;148(2):293-304. doi:<a href=\"https://doi.org/10.1083/jcb.148.2.293\">10.1083/jcb.148.2.293</a>","chicago":"Hetzer, Martin, and Iain W. Mattaj. “An Atp-Dependent, Ran-Independent Mechanism for Nuclear Import of the U1a and U2b′′ Spliceosome Proteins.” <i>Journal of Cell Biology</i>. Rockefeller University Press, 2000. <a href=\"https://doi.org/10.1083/jcb.148.2.293\">https://doi.org/10.1083/jcb.148.2.293</a>.","ieee":"M. Hetzer and I. W. Mattaj, “An Atp-dependent, Ran-independent mechanism for nuclear import of the U1a and U2b′′ spliceosome proteins,” <i>Journal of Cell Biology</i>, vol. 148, no. 2. Rockefeller University Press, pp. 293–304, 2000.","apa":"Hetzer, M., &#38; Mattaj, I. W. (2000). An Atp-dependent, Ran-independent mechanism for nuclear import of the U1a and U2b′′ spliceosome proteins. <i>Journal of Cell Biology</i>. Rockefeller University Press. <a href=\"https://doi.org/10.1083/jcb.148.2.293\">https://doi.org/10.1083/jcb.148.2.293</a>","short":"M. Hetzer, I.W. Mattaj, Journal of Cell Biology 148 (2000) 293–304."},"quality_controlled":"1","status":"public","pmid":1,"language":[{"iso":"eng"}],"publication_status":"published","abstract":[{"lang":"eng","text":"Nuclear import of the two uracil-rich small nuclear ribonucleoprotein (U snRNP) components U1A and U2B′′ is mediated by unusually long and complex nuclear localization signals (NLSs). Here we investigate nuclear import of U1A and U2B′′ in vitro and demonstrate that it occurs by an active, saturable process. Several lines of evidence suggest that import of the two proteins occurs by an import mechanism different to those characterized previously. No cross competition is seen with a variety of previously studied NLSs. In contrast to import mediated by members of the importin-β family of nucleocytoplasmic transport receptors, U1A/U2B′′ import is not inhibited by either nonhydrolyzable guanosine triphosphate (GTP) analogues or by a mutant of the GTPase Ran that is incapable of GTP hydrolysis. Adenosine triphosphate is capable of supporting U1A and U2B′′ import, whereas neither nonhydrolyzable adenosine triphosphate analogues nor GTP can do so. U1A and U2B′′ import in vitro does not require the addition of soluble cytosolic proteins, but a factor or factors required for U1A and U2B′′ import remains tightly associated with the nuclear fraction of conventionally permeabilized cells. This activity can be solubilized in the presence of elevated MgCl2. These data suggest that U1A and U2B′′ import into the nucleus occurs by a hitherto uncharacterized mechanism."}],"day":"24","publisher":"Rockefeller University Press","oa_version":"None","doi":"10.1083/jcb.148.2.293","year":"2000","author":[{"last_name":"HETZER","orcid":"0000-0002-2111-992X","full_name":"HETZER, Martin W","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","first_name":"Martin W"},{"last_name":"Mattaj","full_name":"Mattaj, Iain W.","first_name":"Iain W."}],"publication_identifier":{"eissn":["1540-8140"],"issn":["0021-9525"]},"extern":"1","scopus_import":"1","intvolume":"       148","issue":"2","user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","volume":148,"external_id":{"pmid":["10648562"]},"date_created":"2022-04-07T07:57:49Z","_id":"11126","page":"293-304","publication":"Journal of Cell Biology","article_processing_charge":"No","keyword":["Cell Biology"],"date_published":"2000-01-24T00:00:00Z","month":"01","date_updated":"2022-07-18T08:58:29Z","title":"An Atp-dependent, Ran-independent mechanism for nuclear import of the U1a and U2b′′ spliceosome proteins"},{"main_file_link":[{"url":"https://doi.org/10.1016/S1097-2765(00)80266-X","open_access":"1"}],"volume":5,"oa":1,"intvolume":"         5","issue":"6","user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","extern":"1","scopus_import":"1","month":"06","date_updated":"2022-07-18T08:58:31Z","title":"GTP hydrolysis by Ran is required for nuclear envelope assembly","keyword":["Cell Biology","Molecular Biology"],"article_processing_charge":"No","date_published":"2000-06-01T00:00:00Z","page":"1013-1024","publication":"Molecular Cell","external_id":{"pmid":["10911995"]},"date_created":"2022-04-07T07:57:59Z","_id":"11127","status":"public","pmid":1,"language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"Nuclear formation in Xenopus egg extracts requires cytosol and is inhibited by GTPγS, indicating a requirement for GTPase activity. Nuclear envelope (NE) vesicle fusion is extensively inhibited by GTPγS and two mutant forms of the Ran GTPase, Q69L and T24N. Depletion of either Ran or RCC1, the exchange factor for Ran, from the assembly reaction also inhibits this step of NE formation. Ran depletion can be complemented by the addition of Ran loaded with either GTP or GDP but not with GTPγS. RCC1 depletion is only complemented by RCC1 itself or by RanGTP. Thus, generation of RanGTP by RCC1 and GTP hydrolysis by Ran are both required for the extensive membrane fusion events that lead to NE formation."}],"publication_status":"published","quality_controlled":"1","citation":{"ama":"Hetzer M, Bilbao-Cortés D, Walther TC, Gruss OJ, Mattaj IW. GTP hydrolysis by Ran is required for nuclear envelope assembly. <i>Molecular Cell</i>. 2000;5(6):1013-1024. doi:<a href=\"https://doi.org/10.1016/s1097-2765(00)80266-x\">10.1016/s1097-2765(00)80266-x</a>","chicago":"Hetzer, Martin, Daniel Bilbao-Cortés, Tobias C Walther, Oliver J Gruss, and Iain W Mattaj. “GTP Hydrolysis by Ran Is Required for Nuclear Envelope Assembly.” <i>Molecular Cell</i>. Elsevier, 2000. <a href=\"https://doi.org/10.1016/s1097-2765(00)80266-x\">https://doi.org/10.1016/s1097-2765(00)80266-x</a>.","mla":"Hetzer, Martin, et al. “GTP Hydrolysis by Ran Is Required for Nuclear Envelope Assembly.” <i>Molecular Cell</i>, vol. 5, no. 6, Elsevier, 2000, pp. 1013–24, doi:<a href=\"https://doi.org/10.1016/s1097-2765(00)80266-x\">10.1016/s1097-2765(00)80266-x</a>.","ista":"Hetzer M, Bilbao-Cortés D, Walther TC, Gruss OJ, Mattaj IW. 2000. GTP hydrolysis by Ran is required for nuclear envelope assembly. Molecular Cell. 5(6), 1013–1024.","apa":"Hetzer, M., Bilbao-Cortés, D., Walther, T. C., Gruss, O. J., &#38; Mattaj, I. W. (2000). GTP hydrolysis by Ran is required for nuclear envelope assembly. <i>Molecular Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/s1097-2765(00)80266-x\">https://doi.org/10.1016/s1097-2765(00)80266-x</a>","short":"M. Hetzer, D. Bilbao-Cortés, T.C. Walther, O.J. Gruss, I.W. Mattaj, Molecular Cell 5 (2000) 1013–1024.","ieee":"M. Hetzer, D. Bilbao-Cortés, T. C. Walther, O. J. Gruss, and I. W. Mattaj, “GTP hydrolysis by Ran is required for nuclear envelope assembly,” <i>Molecular Cell</i>, vol. 5, no. 6. Elsevier, pp. 1013–1024, 2000."},"type":"journal_article","article_type":"original","publication_identifier":{"issn":["1097-2765"]},"year":"2000","author":[{"id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","first_name":"Martin W","full_name":"HETZER, Martin W","orcid":"0000-0002-2111-992X","last_name":"HETZER"},{"first_name":"Daniel","full_name":"Bilbao-Cortés, Daniel","last_name":"Bilbao-Cortés"},{"full_name":"Walther, Tobias C","last_name":"Walther","first_name":"Tobias C"},{"first_name":"Oliver J","full_name":"Gruss, Oliver J","last_name":"Gruss"},{"first_name":"Iain W","full_name":"Mattaj, Iain W","last_name":"Mattaj"}],"oa_version":"Published Version","doi":"10.1016/s1097-2765(00)80266-x","day":"01","publisher":"Elsevier"},{"page":"222-250","publication":"Journal of Algorithms","date_created":"2022-07-28T08:56:10Z","_id":"11683","month":"02","date_updated":"2022-09-12T09:06:48Z","title":"Computing vertex connectivity: New bounds from old techniques","article_processing_charge":"No","keyword":["Computational Theory and Mathematics","Computational Mathematics","Control and Optimization"],"date_published":"2000-02-01T00:00:00Z","extern":"1","scopus_import":"1","volume":34,"intvolume":"        34","issue":"2","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa_version":"None","doi":"10.1006/jagm.1999.1055","day":"01","publisher":"Elsevier","publication_identifier":{"issn":["0196-6774"]},"year":"2000","author":[{"first_name":"Monika H","id":"540c9bbd-f2de-11ec-812d-d04a5be85630","last_name":"Henzinger","full_name":"Henzinger, Monika H","orcid":"0000-0002-5008-6530"},{"full_name":"Rao, Satish","last_name":"Rao","first_name":"Satish"},{"full_name":"Gabow, Harold N.","last_name":"Gabow","first_name":"Harold N."}],"type":"journal_article","citation":{"mla":"Henzinger, Monika H., et al. “Computing Vertex Connectivity: New Bounds from Old Techniques.” <i>Journal of Algorithms</i>, vol. 34, no. 2, Elsevier, 2000, pp. 222–50, doi:<a href=\"https://doi.org/10.1006/jagm.1999.1055\">10.1006/jagm.1999.1055</a>.","ista":"Henzinger MH, Rao S, Gabow HN. 2000. Computing vertex connectivity: New bounds from old techniques. Journal of Algorithms. 34(2), 222–250.","ama":"Henzinger MH, Rao S, Gabow HN. Computing vertex connectivity: New bounds from old techniques. <i>Journal of Algorithms</i>. 2000;34(2):222-250. doi:<a href=\"https://doi.org/10.1006/jagm.1999.1055\">10.1006/jagm.1999.1055</a>","chicago":"Henzinger, Monika H, Satish Rao, and Harold N. Gabow. “Computing Vertex Connectivity: New Bounds from Old Techniques.” <i>Journal of Algorithms</i>. Elsevier, 2000. <a href=\"https://doi.org/10.1006/jagm.1999.1055\">https://doi.org/10.1006/jagm.1999.1055</a>.","ieee":"M. H. Henzinger, S. Rao, and H. N. Gabow, “Computing vertex connectivity: New bounds from old techniques,” <i>Journal of Algorithms</i>, vol. 34, no. 2. Elsevier, pp. 222–250, 2000.","apa":"Henzinger, M. H., Rao, S., &#38; Gabow, H. N. (2000). Computing vertex connectivity: New bounds from old techniques. <i>Journal of Algorithms</i>. Elsevier. <a href=\"https://doi.org/10.1006/jagm.1999.1055\">https://doi.org/10.1006/jagm.1999.1055</a>","short":"M.H. Henzinger, S. Rao, H.N. Gabow, Journal of Algorithms 34 (2000) 222–250."},"article_type":"original","status":"public","language":[{"iso":"eng"}],"abstract":[{"text":"The vertex connectivity κ of a graph is the smallest number of vertices whose deletion separates the graph or makes it trivial. We present the fastest known deterministic algorithm for finding the vertex connectivity and a corresponding separator. The time for a digraph having n vertices and m edges is O(min{κ3 + n, κn}m); for an undirected graph the term m can be replaced by κn. A randomized algorithm finds κ with error probability 1/2 in time O(nm). If the vertices have nonnegative weights the weighted vertex connectivity is found in time O(κ1nmlog(n2/m)) where κ1 ≤ m/n is the unweighted vertex connectivity or in expected time O(nmlog(n2/m)) with error probability 1/2. The main algorithm combines two previous vertex connectivity algorithms and a generalization of the preflow-push algorithm of Hao and Orlin (1994, J. Algorithms17, 424–446) that computes edge connectivity.","lang":"eng"}],"publication_status":"published","quality_controlled":"1"},{"day":"01","publisher":"Elsevier","oa_version":"None","doi":"10.1016/s1389-1286(00)00055-4","author":[{"first_name":"Monika H","id":"540c9bbd-f2de-11ec-812d-d04a5be85630","orcid":"0000-0002-5008-6530","full_name":"Henzinger, Monika H","last_name":"Henzinger"},{"first_name":"Allan","full_name":"Heydon, Allan","last_name":"Heydon"},{"full_name":"Mitzenmacher, Michael","last_name":"Mitzenmacher","first_name":"Michael"},{"first_name":"Marc","last_name":"Najork","full_name":"Najork, Marc"}],"year":"2000","publication_identifier":{"issn":["1389-1286"]},"article_type":"original","type":"journal_article","citation":{"ieee":"M. H. Henzinger, A. Heydon, M. Mitzenmacher, and M. Najork, “On near-uniform URL sampling,” <i>Computer Networks</i>, vol. 33, no. 1–6. Elsevier, pp. 295–308, 2000.","short":"M.H. Henzinger, A. Heydon, M. Mitzenmacher, M. Najork, Computer Networks 33 (2000) 295–308.","apa":"Henzinger, M. H., Heydon, A., Mitzenmacher, M., &#38; Najork, M. (2000). On near-uniform URL sampling. <i>Computer Networks</i>. Elsevier. <a href=\"https://doi.org/10.1016/s1389-1286(00)00055-4\">https://doi.org/10.1016/s1389-1286(00)00055-4</a>","ista":"Henzinger MH, Heydon A, Mitzenmacher M, Najork M. 2000. On near-uniform URL sampling. Computer Networks. 33(1–6), 295–308.","mla":"Henzinger, Monika H., et al. “On Near-Uniform URL Sampling.” <i>Computer Networks</i>, vol. 33, no. 1–6, Elsevier, 2000, pp. 295–308, doi:<a href=\"https://doi.org/10.1016/s1389-1286(00)00055-4\">10.1016/s1389-1286(00)00055-4</a>.","chicago":"Henzinger, Monika H, Allan Heydon, Michael Mitzenmacher, and Marc Najork. “On Near-Uniform URL Sampling.” <i>Computer Networks</i>. Elsevier, 2000. <a href=\"https://doi.org/10.1016/s1389-1286(00)00055-4\">https://doi.org/10.1016/s1389-1286(00)00055-4</a>.","ama":"Henzinger MH, Heydon A, Mitzenmacher M, Najork M. On near-uniform URL sampling. <i>Computer Networks</i>. 2000;33(1-6):295-308. doi:<a href=\"https://doi.org/10.1016/s1389-1286(00)00055-4\">10.1016/s1389-1286(00)00055-4</a>"},"quality_controlled":"1","language":[{"iso":"eng"}],"status":"public","publication_status":"published","abstract":[{"text":"We consider the problem of sampling URLs uniformly at random from the Web. A tool for sampling URLs uniformly can be used to estimate various properties of Web pages, such as the fraction of pages in various Internet domains or written in various languages. Moreover, uniform URL sampling can be used to determine the sizes of various search engines relative to the entire Web. In this paper, we consider sampling approaches based on random walks of the Web graph. In particular, we suggest ways of improving sampling based on random walks to make the samples closer to uniform. We suggest a natural test bed based on random graphs for testing the effectiveness of our procedures. We then use our sampling approach to estimate the distribution of pages over various Internet domains and to estimate the coverage of various search engine indexes.","lang":"eng"}],"date_created":"2022-07-28T15:11:53Z","_id":"11685","page":"295-308","publication":"Computer Networks","date_published":"2000-06-01T00:00:00Z","article_processing_charge":"No","keyword":["URL sampling","Random walks","Internet domain distribution","Search engine size"],"month":"06","date_updated":"2022-09-12T09:09:13Z","title":"On near-uniform URL sampling","scopus_import":"1","extern":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","issue":"1-6","intvolume":"        33","volume":33},{"day":"01","publisher":"Society for Industrial and Applied Mathematics","oa_version":"None","doi":"10.1137/s009753979732428x","year":"2000","conference":{"end_date":"1997-05-06","location":"El Paso, TX, United States","start_date":"1997-05-04","name":"STOC97: 29th Annual Symposium on Theory of Computing"},"author":[{"full_name":"Albers, Susanne","last_name":"Albers","first_name":"Susanne"},{"first_name":"Monika H","id":"540c9bbd-f2de-11ec-812d-d04a5be85630","last_name":"Henzinger","orcid":"0000-0002-5008-6530","full_name":"Henzinger, Monika H"}],"publication_identifier":{"issn":["0097-5397"],"eissn":["1095-7111"]},"article_type":"original","type":"journal_article","citation":{"short":"S. Albers, M.H. Henzinger, SIAM Journal on Computing 29 (2000) 1164–1188.","apa":"Albers, S., &#38; Henzinger, M. H. (2000). Exploring unknown environments. <i>SIAM Journal on Computing</i>. El Paso, TX, United States: Society for Industrial and Applied Mathematics. <a href=\"https://doi.org/10.1137/s009753979732428x\">https://doi.org/10.1137/s009753979732428x</a>","ieee":"S. Albers and M. H. Henzinger, “Exploring unknown environments,” <i>SIAM Journal on Computing</i>, vol. 29, no. 4. Society for Industrial and Applied Mathematics, pp. 1164–1188, 2000.","ama":"Albers S, Henzinger MH. Exploring unknown environments. <i>SIAM Journal on Computing</i>. 2000;29(4):1164-1188. doi:<a href=\"https://doi.org/10.1137/s009753979732428x\">10.1137/s009753979732428x</a>","chicago":"Albers, Susanne, and Monika H Henzinger. “Exploring Unknown Environments.” <i>SIAM Journal on Computing</i>. Society for Industrial and Applied Mathematics, 2000. <a href=\"https://doi.org/10.1137/s009753979732428x\">https://doi.org/10.1137/s009753979732428x</a>.","mla":"Albers, Susanne, and Monika H. Henzinger. “Exploring Unknown Environments.” <i>SIAM Journal on Computing</i>, vol. 29, no. 4, Society for Industrial and Applied Mathematics, 2000, pp. 1164–88, doi:<a href=\"https://doi.org/10.1137/s009753979732428x\">10.1137/s009753979732428x</a>.","ista":"Albers S, Henzinger MH. 2000. Exploring unknown environments. SIAM Journal on Computing. 29(4), 1164–1188."},"quality_controlled":"1","status":"public","language":[{"iso":"eng"}],"publication_status":"published","abstract":[{"lang":"eng","text":"We consider exploration problems where a robot has to construct a complete map of an unknown environment. We assume that the environment is modeled by a directed, strongly connected graph. The robot's task is to visit all nodes and edges of the graph using the minimum number R of edge traversals. Deng and Papadimitriou [Proceedings of the 31st Symposium on the Foundations of Computer Science, 1990, pp. 356-361] showed an upper bound for R ofd O(d)m and Koutsoupias (reported by Deng and Papadimitriou) gave a lower bound of Ω≠(d2m), where m is the number of edges in the graph and d is the minimum number of edges that have to be added to make the graph Eulerian.  We give the 1rst subexponential algorithm for this exploration problem, which achieves an upper bound of dO(logd)m.  We also show a matching lower bound of d≠(logd)m for our algorithm. Additionally, we give lower bounds of 2≠(d)m, respectively, d≠(logd)m for various other natural exploration algorithms."}],"date_created":"2022-07-29T09:04:36Z","_id":"11694","page":"1164-1188","publication":"SIAM Journal on Computing","keyword":["directed graph","exploration algorithm"],"article_processing_charge":"No","date_published":"2000-07-01T00:00:00Z","month":"07","title":"Exploring unknown environments","date_updated":"2023-02-17T14:41:36Z","extern":"1","scopus_import":"1","intvolume":"        29","acknowledgement":"We thank Prabhakar Raghavan for bringing to our attention the literature on the s-t connectivity  problem. We also thank  an anonymous referee for many helpful comments which improved the presentation of the paper.","issue":"4","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","volume":29},{"language":[{"iso":"eng"}],"status":"public","publication_status":"published","abstract":[{"text":"We compare several algorithms for identifying mirrored hosts on the World Wide Web. The algorithms operate on the basis of URL strings and linkage data: the type of information about Web pages easily available from Web proxies and crawlers. Identification of mirrored hosts can improve Web-based information retrieval in several ways: first, by identifying mirrored hosts, search engines can avoid storing and returning duplicate documents. Second, several new information retrieval techniques for the Web make inferences based on the explicit links among hypertext documents—mirroring perturbs their graph model and degrades performance. Third, mirroring information can be used to redirect users to alternate mirror sites to compensate for various failures, and can thus improve the performance of Web browsers and proxies. We evaluated four classes of “top-down” algorithms for detecting mirrored host pairs (that is, algorithms that are based on page attributes such as URL, IP address, and hyperlinks between pages, and not on the page content) on a collection of 140 million URLs (on 230,000 hosts) and their associated connectivity information. Our best approach is one which combines five algorithms and achieved a precision of 0.57 for a recall of 0.86 considering 100,000 ranked host pairs.","lang":"eng"}],"quality_controlled":"1","type":"journal_article","citation":{"apa":"Bharat, K., Broder, A., Dean, J., &#38; Henzinger, M. H. (2000). A comparison of techniques to find mirrored hosts on the WWW. <i>Journal of the American Society for Information Science</i>. Wiley. <a href=\"https://doi.org/10.1002/1097-4571(2000)9999:9999&#60;::aid-asi1025&#62;3.0.co;2-0\">https://doi.org/10.1002/1097-4571(2000)9999:9999&#60;::aid-asi1025&#62;3.0.co;2-0</a>","short":"K. Bharat, A. Broder, J. Dean, M.H. Henzinger, Journal of the American Society for Information Science 51 (2000) 1114–1122.","ieee":"K. Bharat, A. Broder, J. Dean, and M. H. Henzinger, “A comparison of techniques to find mirrored hosts on the WWW,” <i>Journal of the American Society for Information Science</i>, vol. 51, no. 12. Wiley, pp. 1114–1122, 2000.","chicago":"Bharat, Krishna, Andrei Broder, Jeffrey Dean, and Monika H Henzinger. “A Comparison of Techniques to Find Mirrored Hosts on the WWW.” <i>Journal of the American Society for Information Science</i>. Wiley, 2000. <a href=\"https://doi.org/10.1002/1097-4571(2000)9999:9999&#60;::aid-asi1025&#62;3.0.co;2-0\">https://doi.org/10.1002/1097-4571(2000)9999:9999&#60;::aid-asi1025&#62;3.0.co;2-0</a>.","ama":"Bharat K, Broder A, Dean J, Henzinger MH. A comparison of techniques to find mirrored hosts on the WWW. <i>Journal of the American Society for Information Science</i>. 2000;51(12):1114-1122. doi:<a href=\"https://doi.org/10.1002/1097-4571(2000)9999:9999&#60;::aid-asi1025&#62;3.0.co;2-0\">10.1002/1097-4571(2000)9999:9999&#60;::aid-asi1025&#62;3.0.co;2-0</a>","mla":"Bharat, Krishna, et al. “A Comparison of Techniques to Find Mirrored Hosts on the WWW.” <i>Journal of the American Society for Information Science</i>, vol. 51, no. 12, Wiley, 2000, pp. 1114–22, doi:<a href=\"https://doi.org/10.1002/1097-4571(2000)9999:9999&#60;::aid-asi1025&#62;3.0.co;2-0\">10.1002/1097-4571(2000)9999:9999&#60;::aid-asi1025&#62;3.0.co;2-0</a>.","ista":"Bharat K, Broder A, Dean J, Henzinger MH. 2000. A comparison of techniques to find mirrored hosts on the WWW. Journal of the American Society for Information Science. 51(12), 1114–1122."},"article_type":"original","publication_identifier":{"issn":["0002-8231","1097-4571"]},"author":[{"full_name":"Bharat, Krishna","last_name":"Bharat","first_name":"Krishna"},{"last_name":"Broder","full_name":"Broder, Andrei","first_name":"Andrei"},{"first_name":"Jeffrey","full_name":"Dean, Jeffrey","last_name":"Dean"},{"orcid":"0000-0002-5008-6530","full_name":"Henzinger, Monika H","last_name":"Henzinger","first_name":"Monika H","id":"540c9bbd-f2de-11ec-812d-d04a5be85630"}],"year":"2000","oa_version":"Published Version","doi":"10.1002/1097-4571(2000)9999:9999<::aid-asi1025>3.0.co;2-0","day":"01","publisher":"Wiley","volume":51,"main_file_link":[{"url":"https://doi.org/10.1002/1097-4571(2000)9999:9999<::aid-asi1025>3.0.co;2-0","open_access":"1"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","issue":"12","oa":1,"intvolume":"        51","scopus_import":"1","extern":"1","month":"10","date_updated":"2023-02-10T08:27:19Z","title":"A comparison of techniques to find mirrored hosts on the WWW","date_published":"2000-10-01T00:00:00Z","article_processing_charge":"No","page":"1114-1122","publication":"Journal of the American Society for Information Science","date_created":"2022-08-08T12:57:37Z","_id":"11770"},{"citation":{"mla":"Henzinger, Monika H. “Web Information Retrieval - an Algorithmic Perspective.” <i>8th Annual European Symposium on Algorithms</i>, vol. 1879, Springer Nature, 2000, pp. 1–8, doi:<a href=\"https://doi.org/10.1007/3-540-45253-2_1\">10.1007/3-540-45253-2_1</a>.","ista":"Henzinger MH. 2000. Web information retrieval - an algorithmic perspective. 8th Annual European Symposium on Algorithms. ESA: European Symposium on Algorithms, LNCS, vol. 1879, 1–8.","ama":"Henzinger MH. Web information retrieval - an algorithmic perspective. In: <i>8th Annual European Symposium on Algorithms</i>. Vol 1879. Springer Nature; 2000:1–8. doi:<a href=\"https://doi.org/10.1007/3-540-45253-2_1\">10.1007/3-540-45253-2_1</a>","chicago":"Henzinger, Monika H. “Web Information Retrieval - an Algorithmic Perspective.” In <i>8th Annual European Symposium on Algorithms</i>, 1879:1–8. Springer Nature, 2000. <a href=\"https://doi.org/10.1007/3-540-45253-2_1\">https://doi.org/10.1007/3-540-45253-2_1</a>.","ieee":"M. H. Henzinger, “Web information retrieval - an algorithmic perspective,” in <i>8th Annual European Symposium on Algorithms</i>, Saarbrücken, Germany, 2000, vol. 1879, pp. 1–8.","short":"M.H. Henzinger, in:, 8th Annual European Symposium on Algorithms, Springer Nature, 2000, pp. 1–8.","apa":"Henzinger, M. H. (2000). Web information retrieval - an algorithmic perspective. In <i>8th Annual European Symposium on Algorithms</i> (Vol. 1879, pp. 1–8). Saarbrücken, Germany: Springer Nature. <a href=\"https://doi.org/10.1007/3-540-45253-2_1\">https://doi.org/10.1007/3-540-45253-2_1</a>"},"scopus_import":"1","type":"conference","extern":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":"      1879","quality_controlled":"1","language":[{"iso":"eng"}],"status":"public","publication_status":"published","alternative_title":["LNCS"],"volume":1879,"abstract":[{"lang":"eng","text":"In this paper we survey algorithmic aspects of Web information retrieval. As an example, we discuss ranking of search engine results using connectivity analysis."}],"date_created":"2022-08-11T13:25:07Z","day":"01","publisher":"Springer Nature","_id":"11802","page":"1–8","oa_version":"None","doi":"10.1007/3-540-45253-2_1","publication":"8th Annual European Symposium on Algorithms","date_published":"2000-09-01T00:00:00Z","author":[{"last_name":"Henzinger","full_name":"Henzinger, Monika H","orcid":"0000-0002-5008-6530","first_name":"Monika H","id":"540c9bbd-f2de-11ec-812d-d04a5be85630"}],"conference":{"name":"ESA: European Symposium on Algorithms","end_date":"2000-09-08","start_date":"2000-09-05","location":"Saarbrücken, Germany"},"article_processing_charge":"No","year":"2000","month":"09","title":"Web information retrieval - an algorithmic perspective","date_updated":"2023-02-13T12:08:21Z","publication_identifier":{"isbn":["9783540410041"],"eissn":["1611-3349"],"eisbn":["9783540452539"],"issn":["0302-9743"]}},{"quality_controlled":"1","issue":"6","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":"        29","publication_status":"published","volume":29,"abstract":[{"lang":"eng","text":"We present fully dynamic algorithms for maintaining the biconnected components in general and plane graphs.\r\n\r\nA fully dynamic algorithm maintains a graph during a sequence of insertions and deletions of edges or isolated vertices. Let m be the number of edges and n be the number of vertices in a graph. The time per operation of the best deterministic algorithms is 𝑂(𝑛√) in general graphs and O(log n) in plane graphs for fully dynamic connectivity and O(min m2/3 ,n}) in general graphs and 𝑂(𝑛√) in plane graphs for fully dynamic biconnectivity. We improve the later running times to 𝑂(𝑚log𝑛‾‾‾‾‾‾‾√) in general graphs and O(log 2n ) in plane graphs. Our algorithm for general graphscan also find the biconnected components of all vertices in time O(n)."}],"language":[{"iso":"eng"}],"status":"public","article_type":"original","type":"journal_article","scopus_import":"1","citation":{"ista":"Henzinger MH. 2000. Improved data structures for fully dynamic biconnectivity. SIAM Journal on Computing. 29(6), 1761–1815.","mla":"Henzinger, Monika H. “Improved Data Structures for Fully Dynamic Biconnectivity.” <i>SIAM Journal on Computing</i>, vol. 29, no. 6, Society for Industrial &#38; Applied Mathematics, 2000, pp. 1761–815, doi:<a href=\"https://doi.org/10.1137/s0097539794263907\">10.1137/s0097539794263907</a>.","chicago":"Henzinger, Monika H. “Improved Data Structures for Fully Dynamic Biconnectivity.” <i>SIAM Journal on Computing</i>. Society for Industrial &#38; Applied Mathematics, 2000. <a href=\"https://doi.org/10.1137/s0097539794263907\">https://doi.org/10.1137/s0097539794263907</a>.","ama":"Henzinger MH. Improved data structures for fully dynamic biconnectivity. <i>SIAM Journal on Computing</i>. 2000;29(6):1761-1815. doi:<a href=\"https://doi.org/10.1137/s0097539794263907\">10.1137/s0097539794263907</a>","ieee":"M. H. Henzinger, “Improved data structures for fully dynamic biconnectivity,” <i>SIAM Journal on Computing</i>, vol. 29, no. 6. Society for Industrial &#38; Applied Mathematics, pp. 1761–1815, 2000.","short":"M.H. Henzinger, SIAM Journal on Computing 29 (2000) 1761–1815.","apa":"Henzinger, M. H. (2000). Improved data structures for fully dynamic biconnectivity. <i>SIAM Journal on Computing</i>. Society for Industrial &#38; Applied Mathematics. <a href=\"https://doi.org/10.1137/s0097539794263907\">https://doi.org/10.1137/s0097539794263907</a>"},"extern":"1","date_published":"2000-11-01T00:00:00Z","author":[{"first_name":"Monika H","id":"540c9bbd-f2de-11ec-812d-d04a5be85630","last_name":"Henzinger","orcid":"0000-0002-5008-6530","full_name":"Henzinger, Monika H"}],"article_processing_charge":"No","year":"2000","title":"Improved data structures for fully dynamic biconnectivity","date_updated":"2023-02-17T14:39:47Z","publication_identifier":{"eissn":["1095-7111"],"issn":["0097-5397"]},"month":"11","publisher":"Society for Industrial & Applied Mathematics","_id":"11893","date_created":"2022-08-17T08:45:41Z","day":"01","doi":"10.1137/s0097539794263907","publication":"SIAM Journal on Computing","oa_version":"None","page":"1761-1815"},{"_id":"2325","publisher":"American Mathematical Society","date_created":"2018-12-11T11:57:00Z","day":"01","doi":"10.1090/conm/529","page":"53 - 72","author":[{"full_name":"Robert Seiringer","orcid":"0000-0002-6781-0521","last_name":"Seiringer","first_name":"Robert","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87"}],"date_published":"2000-01-01T00:00:00Z","conference":{"name":"Arizona School of Analysis With Applications"},"year":"2000","date_updated":"2021-01-12T06:56:47Z","title":"Inequalities for Schrödinger operators and applications to the stability of matter problem ","month":"01","citation":{"ama":"Seiringer R. Inequalities for Schrödinger operators and applications to the stability of matter problem . In: Vol 529. American Mathematical Society; 2000:53-72. doi:<a href=\"https://doi.org/10.1090/conm/529\">10.1090/conm/529</a>","chicago":"Seiringer, Robert. “Inequalities for Schrödinger Operators and Applications to the Stability of Matter Problem ,” 529:53–72. American Mathematical Society, 2000. <a href=\"https://doi.org/10.1090/conm/529\">https://doi.org/10.1090/conm/529</a>.","ista":"Seiringer R. 2000. Inequalities for Schrödinger operators and applications to the stability of matter problem . Arizona School of Analysis With Applications, Contemporary Mathematics, vol. 529, 53–72.","mla":"Seiringer, Robert. <i>Inequalities for Schrödinger Operators and Applications to the Stability of Matter Problem </i>. Vol. 529, American Mathematical Society, 2000, pp. 53–72, doi:<a href=\"https://doi.org/10.1090/conm/529\">10.1090/conm/529</a>.","apa":"Seiringer, R. (2000). Inequalities for Schrödinger operators and applications to the stability of matter problem  (Vol. 529, pp. 53–72). Presented at the Arizona School of Analysis With Applications, American Mathematical Society. <a href=\"https://doi.org/10.1090/conm/529\">https://doi.org/10.1090/conm/529</a>","short":"R. Seiringer, in:, American Mathematical Society, 2000, pp. 53–72.","ieee":"R. Seiringer, “Inequalities for Schrödinger operators and applications to the stability of matter problem ,” presented at the Arizona School of Analysis With Applications, 2000, vol. 529, pp. 53–72."},"type":"conference","extern":1,"quality_controlled":0,"intvolume":"       529","alternative_title":["Contemporary Mathematics"],"volume":529,"publication_status":"published","publist_id":"4602","status":"public"},{"publication":"Proceedings of the International Symposium on Quantum Theory and Symmetries","page":"101 - 110","oa_version":"None","arxiv":1,"publisher":"World Scientific Publishing","_id":"2342","day":"01","external_id":{"arxiv":["math-ph/9911026"]},"date_created":"2018-12-11T11:57:06Z","publication_identifier":{"isbn":["9789810242374 "]},"title":"The ground state energy and density of interacting bosons in a trap","date_updated":"2023-05-03T13:00:35Z","month":"06","conference":{"name":"ISQTS: Quantum Theory and Symmetries"},"year":"2000","article_processing_charge":"No","author":[{"full_name":"Seiringer, Robert","orcid":"0000-0002-6781-0521","last_name":"Seiringer","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","first_name":"Robert"},{"last_name":"Lieb","full_name":"Lieb, Élliott","first_name":"Élliott"},{"first_name":"Jakob","last_name":"Yngvason","full_name":"Yngvason, Jakob"}],"date_published":"2000-06-01T00:00:00Z","extern":"1","citation":{"short":"R. Seiringer, É. Lieb, J. Yngvason, in:, Proceedings of the International Symposium on Quantum Theory and Symmetries, World Scientific Publishing, 2000, pp. 101–110.","apa":"Seiringer, R., Lieb, É., &#38; Yngvason, J. (2000). The ground state energy and density of interacting bosons in a trap. In <i>Proceedings of the International Symposium on Quantum Theory and Symmetries</i> (pp. 101–110). World Scientific Publishing.","ieee":"R. Seiringer, É. Lieb, and J. Yngvason, “The ground state energy and density of interacting bosons in a trap,” in <i>Proceedings of the International Symposium on Quantum Theory and Symmetries</i>, 2000, pp. 101–110.","chicago":"Seiringer, Robert, Élliott Lieb, and Jakob Yngvason. “The Ground State Energy and Density of Interacting Bosons in a Trap.” In <i>Proceedings of the International Symposium on Quantum Theory and Symmetries</i>, 101–10. World Scientific Publishing, 2000.","ama":"Seiringer R, Lieb É, Yngvason J. The ground state energy and density of interacting bosons in a trap. In: <i>Proceedings of the International Symposium on Quantum Theory and Symmetries</i>. World Scientific Publishing; 2000:101-110.","ista":"Seiringer R, Lieb É, Yngvason J. 2000. The ground state energy and density of interacting bosons in a trap. Proceedings of the International Symposium on Quantum Theory and Symmetries. ISQTS: Quantum Theory and Symmetries, 101–110.","mla":"Seiringer, Robert, et al. “The Ground State Energy and Density of Interacting Bosons in a Trap.” <i>Proceedings of the International Symposium on Quantum Theory and Symmetries</i>, World Scientific Publishing, 2000, pp. 101–10."},"type":"conference","main_file_link":[{"url":"http://arxiv.org/abs/math-ph/9911026","open_access":"1"}],"publist_id":"4584","abstract":[{"text":"In the theoretical description of recent experiments with dilute Bose gases confined in external potentials the Gross-Pitaevskii equation plays an important role. Its status as an approximation for the quantum mechanical many-body ground state problem has recently been rigorously clarified. A summary of this work is presented here.","lang":"eng"}],"publication_status":"published","status":"public","language":[{"iso":"eng"}],"quality_controlled":"1","oa":1,"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17"},{"month":"11","date_updated":"2021-01-12T06:56:54Z","title":"On the ordering of energy levels in homogeneous magnetic fields","date_published":"2000-11-01T00:00:00Z","author":[{"last_name":"Baumgartner","full_name":"Baumgartner, Bernhard","first_name":"Bernhard"},{"orcid":"0000-0002-6781-0521","full_name":"Robert Seiringer","last_name":"Seiringer","first_name":"Robert","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87"}],"year":"2000","page":"213 - 226","publication":"Letters in Mathematical Physics","doi":"    10.1023/A:1010978807635","date_created":"2018-12-11T11:57:06Z","day":"01","publisher":"Springer","_id":"2343","status":"public","volume":54,"publication_status":"published","abstract":[{"text":"We study the energy levels of a single particle in a homogeneous magnetic field and in an axially symmetric external potential. For potentials that are superharmonic off the central axis, we find a general 'pseudoconcave' ordering of the ground state energies of the Hamiltonian restricted to the sectors with fixed angular momentum. The physical applications include atoms and ions in strong magnetic fields. There the energies are monotone increasing and concave in angular momentum. In the case of a periodic chain of atoms, the pseudoconcavity extends to the entire lowest band of Bloch functions.","lang":"eng"}],"publist_id":"4582","main_file_link":[{"open_access":"1","url":"http://arxiv.org/abs/math-ph/0011031"}],"issue":"3","oa":1,"intvolume":"        54","quality_controlled":0,"type":"journal_article","citation":{"mla":"Baumgartner, Bernhard, and Robert Seiringer. “On the Ordering of Energy Levels in Homogeneous Magnetic Fields.” <i>Letters in Mathematical Physics</i>, vol. 54, no. 3, Springer, 2000, pp. 213–26, doi:<a href=\"https://doi.org/    10.1023/A:1010978807635\">    10.1023/A:1010978807635</a>.","ista":"Baumgartner B, Seiringer R. 2000. On the ordering of energy levels in homogeneous magnetic fields. Letters in Mathematical Physics. 54(3), 213–226.","chicago":"Baumgartner, Bernhard, and Robert Seiringer. “On the Ordering of Energy Levels in Homogeneous Magnetic Fields.” <i>Letters in Mathematical Physics</i>. Springer, 2000. <a href=\"https://doi.org/    10.1023/A:1010978807635\">https://doi.org/    10.1023/A:1010978807635</a>.","ama":"Baumgartner B, Seiringer R. On the ordering of energy levels in homogeneous magnetic fields. <i>Letters in Mathematical Physics</i>. 2000;54(3):213-226. doi:<a href=\"https://doi.org/    10.1023/A:1010978807635\">    10.1023/A:1010978807635</a>","ieee":"B. Baumgartner and R. Seiringer, “On the ordering of energy levels in homogeneous magnetic fields,” <i>Letters in Mathematical Physics</i>, vol. 54, no. 3. Springer, pp. 213–226, 2000.","short":"B. Baumgartner, R. Seiringer, Letters in Mathematical Physics 54 (2000) 213–226.","apa":"Baumgartner, B., &#38; Seiringer, R. (2000). On the ordering of energy levels in homogeneous magnetic fields. <i>Letters in Mathematical Physics</i>. Springer. <a href=\"https://doi.org/    10.1023/A:1010978807635\">https://doi.org/    10.1023/A:1010978807635</a>"},"extern":1},{"article_type":"original","type":"journal_article","citation":{"ista":"Lieb É, Seiringer R, Yngvason J. 2000. Bosons in a trap: A rigorous derivation of the Gross-Pitaevskii energy functional. Physical Review A - Atomic, Molecular, and Optical Physics. 61(4), 436021–4360213.","mla":"Lieb, Élliott, et al. “Bosons in a Trap: A Rigorous Derivation of the Gross-Pitaevskii Energy Functional.” <i>Physical Review A - Atomic, Molecular, and Optical Physics</i>, vol. 61, no. 4, American Physical Society, 2000, pp. 436021–4360213, doi:<a href=\"https://doi.org/10.1103/PhysRevA.61.043602\">10.1103/PhysRevA.61.043602</a>.","ama":"Lieb É, Seiringer R, Yngvason J. Bosons in a trap: A rigorous derivation of the Gross-Pitaevskii energy functional. <i>Physical Review A - Atomic, Molecular, and Optical Physics</i>. 2000;61(4):436021-4360213. doi:<a href=\"https://doi.org/10.1103/PhysRevA.61.043602\">10.1103/PhysRevA.61.043602</a>","chicago":"Lieb, Élliott, Robert Seiringer, and Jakob Yngvason. “Bosons in a Trap: A Rigorous Derivation of the Gross-Pitaevskii Energy Functional.” <i>Physical Review A - Atomic, Molecular, and Optical Physics</i>. American Physical Society, 2000. <a href=\"https://doi.org/10.1103/PhysRevA.61.043602\">https://doi.org/10.1103/PhysRevA.61.043602</a>.","ieee":"É. Lieb, R. Seiringer, and J. Yngvason, “Bosons in a trap: A rigorous derivation of the Gross-Pitaevskii energy functional,” <i>Physical Review A - Atomic, Molecular, and Optical Physics</i>, vol. 61, no. 4. American Physical Society, pp. 436021–4360213, 2000.","apa":"Lieb, É., Seiringer, R., &#38; Yngvason, J. (2000). Bosons in a trap: A rigorous derivation of the Gross-Pitaevskii energy functional. <i>Physical Review A - Atomic, Molecular, and Optical Physics</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevA.61.043602\">https://doi.org/10.1103/PhysRevA.61.043602</a>","short":"É. Lieb, R. Seiringer, J. Yngvason, Physical Review A - Atomic, Molecular, and Optical Physics 61 (2000) 436021–4360213."},"quality_controlled":"1","publist_id":"4583","publication_status":"published","abstract":[{"text":"The ground-state properties of interacting Bose gases in external potentials, as considered in recent experiments, are usually described by means of the Gross-Pitaevskii energy functional. We present here a rigorous proof of the asymptotic exactness of this approximation for the ground-state energy and particle density of a dilute Bose gas with a positive interaction.","lang":"eng"}],"status":"public","language":[{"iso":"eng"}],"publisher":"American Physical Society","day":"01","doi":"10.1103/PhysRevA.61.043602","oa_version":"Published Version","arxiv":1,"year":"2000","author":[{"first_name":"Élliott","last_name":"Lieb","full_name":"Lieb, Élliott"},{"orcid":"0000-0002-6781-0521","full_name":"Seiringer, Robert","last_name":"Seiringer","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","first_name":"Robert"},{"full_name":"Yngvason, Jakob","last_name":"Yngvason","first_name":"Jakob"}],"publication_identifier":{"issn":["0556-2791"]},"extern":"1","scopus_import":"1","oa":1,"intvolume":"        61","issue":"4","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","main_file_link":[{"url":"http://arxiv.org/abs/math-ph/9908027","open_access":"1"}],"volume":61,"_id":"2344","external_id":{"arxiv":["math-ph/9908027"]},"date_created":"2018-12-11T11:57:07Z","publication":"Physical Review A - Atomic, Molecular, and Optical Physics","page":"436021 - 4360213","article_processing_charge":"No","date_published":"2000-04-01T00:00:00Z","date_updated":"2023-05-03T12:47:08Z","title":"Bosons in a trap: A rigorous derivation of the Gross-Pitaevskii energy functional","month":"04"},{"scopus_import":"1","citation":{"ieee":"U. Wagner and E. Welzl, “Origin-embracing distributions or a continuous analogue of the Upper Bound Theorem,” in <i>Proceedings of the 16th annual symposium on Computational geometry</i>, Clear Water Bay Kowloon, Hong Kong, 2000, pp. 50–56.","short":"U. Wagner, E. Welzl, in:, Proceedings of the 16th Annual Symposium on Computational Geometry, ACM, 2000, pp. 50–56.","apa":"Wagner, U., &#38; Welzl, E. (2000). Origin-embracing distributions or a continuous analogue of the Upper Bound Theorem. In <i>Proceedings of the 16th annual symposium on Computational geometry</i> (pp. 50–56). Clear Water Bay Kowloon, Hong Kong: ACM. <a href=\"https://doi.org/10.1145/336154.336176\">https://doi.org/10.1145/336154.336176</a>","ista":"Wagner U, Welzl E. 2000. Origin-embracing distributions or a continuous analogue of the Upper Bound Theorem. Proceedings of the 16th annual symposium on Computational geometry. SCG: Symposium on Computational Geometry, 50–56.","mla":"Wagner, Uli, and Emo Welzl. “Origin-Embracing Distributions or a Continuous Analogue of the Upper Bound Theorem.” <i>Proceedings of the 16th Annual Symposium on Computational Geometry</i>, ACM, 2000, pp. 50–56, doi:<a href=\"https://doi.org/10.1145/336154.336176\">10.1145/336154.336176</a>.","chicago":"Wagner, Uli, and Emo Welzl. “Origin-Embracing Distributions or a Continuous Analogue of the Upper Bound Theorem.” In <i>Proceedings of the 16th Annual Symposium on Computational Geometry</i>, 50–56. ACM, 2000. <a href=\"https://doi.org/10.1145/336154.336176\">https://doi.org/10.1145/336154.336176</a>.","ama":"Wagner U, Welzl E. Origin-embracing distributions or a continuous analogue of the Upper Bound Theorem. In: <i>Proceedings of the 16th Annual Symposium on Computational Geometry</i>. ACM; 2000:50-56. doi:<a href=\"https://doi.org/10.1145/336154.336176\">10.1145/336154.336176</a>"},"type":"conference","extern":"1","language":[{"iso":"eng"}],"status":"public","publication_status":"published","abstract":[{"lang":"eng","text":"For an absolutely continuous probability measure μ on Rd and a nonnegative integer k, let sk(μ, 0) denote the probability that the convex hull of k+d+1 random points which are i.i.d. according to μ contains the origin 0. For d and k given, we determine a tight upper bound on sk(μ, 0), and we characterize the measures in Rd which attain this bound. This result can be considered a continuous analogue of the Upper Bound Theorem for the maximal number of faces of convex polytopes with a given number of vertices. For our proof we introduce so-called h-functions, continuous counterparts of h-vectors for simplicial convex polytopes."}],"publist_id":"4507","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","quality_controlled":"1","page":"50 - 56","oa_version":"None","doi":"10.1145/336154.336176","publication":"Proceedings of the 16th annual symposium on Computational geometry","date_created":"2018-12-11T11:57:33Z","day":"01","publisher":"ACM","_id":"2418","month":"05","title":"Origin-embracing distributions or a continuous analogue of the Upper Bound Theorem","date_updated":"2023-05-03T12:41:02Z","publication_identifier":{"isbn":["9781581132243"]},"author":[{"id":"36690CA2-F248-11E8-B48F-1D18A9856A87","first_name":"Uli","orcid":"0000-0002-1494-0568","full_name":"Wagner, Uli","last_name":"Wagner"},{"first_name":"Emo","last_name":"Welzl","full_name":"Welzl, Emo"}],"date_published":"2000-05-01T00:00:00Z","conference":{"location":"Clear Water Bay Kowloon, Hong Kong","start_date":"2000-06-12","end_date":"2000-04-14","name":"SCG: Symposium on Computational Geometry"},"article_processing_charge":"No","year":"2000"},{"extern":"1","type":"book_chapter","citation":{"ieee":"R. Shigemoto and N. Mizuno, “Chapter III Metabotropic glutamate receptors - immunocytochemical and in situ hybridization analyses,” in <i>Glutamate</i>, vol. 18, Elsevier, 2000, pp. 63–98.","short":"R. Shigemoto, N. Mizuno, in:, Glutamate, Elsevier, 2000, pp. 63–98.","apa":"Shigemoto, R., &#38; Mizuno, N. (2000). Chapter III Metabotropic glutamate receptors - immunocytochemical and in situ hybridization analyses. In <i>Glutamate</i> (Vol. 18, pp. 63–98). Elsevier. <a href=\"https://doi.org/10.1016/S0924-8196(00)80044-5\">https://doi.org/10.1016/S0924-8196(00)80044-5</a>","mla":"Shigemoto, Ryuichi, and Noboru Mizuno. “Chapter III Metabotropic Glutamate Receptors - Immunocytochemical and in Situ Hybridization Analyses.” <i>Glutamate</i>, vol. 18, Elsevier, 2000, pp. 63–98, doi:<a href=\"https://doi.org/10.1016/S0924-8196(00)80044-5\">10.1016/S0924-8196(00)80044-5</a>.","ista":"Shigemoto R, Mizuno N. 2000.Chapter III Metabotropic glutamate receptors - immunocytochemical and in situ hybridization analyses. In: Glutamate. Handbook of Chemical Neuroanatomy, vol. 18, 63–98.","chicago":"Shigemoto, Ryuichi, and Noboru Mizuno. “Chapter III Metabotropic Glutamate Receptors - Immunocytochemical and in Situ Hybridization Analyses.” In <i>Glutamate</i>, 18:63–98. Elsevier, 2000. <a href=\"https://doi.org/10.1016/S0924-8196(00)80044-5\">https://doi.org/10.1016/S0924-8196(00)80044-5</a>.","ama":"Shigemoto R, Mizuno N. Chapter III Metabotropic glutamate receptors - immunocytochemical and in situ hybridization analyses. In: <i>Glutamate</i>. Vol 18. Elsevier; 2000:63-98. doi:<a href=\"https://doi.org/10.1016/S0924-8196(00)80044-5\">10.1016/S0924-8196(00)80044-5</a>"},"quality_controlled":"1","intvolume":"        18","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publist_id":"4407","publication_status":"published","abstract":[{"text":"This chapter focuses on metabotropic glutamate receptors (mGluRs). These receptors are linked to several intracellular signal transduction mechanisms via G-protein and are implicated in diverse functions of the mammalian central nervous system (CNS). These functions include mediation of slow excitatory and inhibitory responses; regulation of calcium channels, potassium channels, and non-selective cation channels; inhibition and facilitation of transmitter release; induction of long-term potentiation and long-term depression; and regulation of neuronal development. Functional diversity of the metabotropic glutamate receptor is reflected in molecular diversity of receptor subtypes. The sites of action of mGluRs are widely found throughout different membrane compartments of neuronal and glial cells. The chapter reviews the differential subcellular localization of metabotropic glutamate receptors in relation to transmitter release sites. Patterns of subcellular localization of mGluRs are different among three subgroups: group I and III mGluRs are mainly localized to somatodendritic and axonal domains of neurons, respectively, while group II mGluRs are extensively localized to both domains as well as to glial cell processes.","lang":"eng"}],"volume":18,"alternative_title":["Handbook of Chemical Neuroanatomy"],"status":"public","language":[{"iso":"eng"}],"_id":"2494","publisher":"Elsevier","day":"01","date_created":"2018-12-11T11:58:00Z","doi":"10.1016/S0924-8196(00)80044-5","publication":"Glutamate","page":"63 - 98","oa_version":"None","year":"2000","article_processing_charge":"No","date_published":"2000-01-01T00:00:00Z","author":[{"first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi"},{"last_name":"Mizuno","full_name":"Mizuno, Noboru","first_name":"Noboru"}],"publication_identifier":{"eissn":["0924-8196"]},"title":"Chapter III Metabotropic glutamate receptors - immunocytochemical and in situ hybridization analyses","date_updated":"2023-05-03T12:27:40Z","month":"01"},{"title":"Paraneoplastic cerebellar ataxia due to autoantibodies against a glutamate receptor","date_updated":"2023-05-03T11:14:19Z","month":"01","article_processing_charge":"No","date_published":"2000-01-06T00:00:00Z","publication":"New England Journal of Medicine","page":"21 - 27","_id":"2598","external_id":{"pmid":["10620645"]},"date_created":"2018-12-11T11:58:35Z","main_file_link":[{"url":"https://www.nejm.org/doi/full/10.1056/nejm200001063420104","open_access":"1"}],"volume":342,"intvolume":"       342","oa":1,"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","issue":"1","acknowledgement":"Supported in part by the Ministry of Education, Science, and Culture of Japan (Dr. Nakanishi and Dr. Shigemoto); CREST of Japan Science and Technology Corporation (Dr. Shigemoto); the Life Sciences Foundation (Dr. De Zeeuw); NWO (Dr. De Zeeuw and Dr. De Leeuw); and the Human Frontier Science Program (Dr. De Zeeuw and Dr. Shigemoto).\r\nDrs. Sillevis Smitt and Kinoshita contributed equally to the article. We are indebted to A. Aiba for providing mGluR1-deficient mice; to T. Maruyama for providing human mGluR1-expressing CHO cells; to H. Jingami for helpful discussion; to A. Uesugi for photographic assistance; to M. van den Bent and C. Gaillard for clinical information on the patients; and to J. van der Burg, S.K.E. Koekkoek, K.J. Reus, and C. Vermeer for technical assistance.","extern":"1","scopus_import":"1","publication_identifier":{"issn":["0028-4793"]},"year":"2000","author":[{"first_name":"Peter","full_name":"Sillevis Smitt, Peter","last_name":"Sillevis Smitt"},{"full_name":"Kinoshita, Ayae","last_name":"Kinoshita","first_name":"Ayae"},{"full_name":"De Leeuw, Bertie","last_name":"De Leeuw","first_name":"Bertie"},{"first_name":"Wiebe","last_name":"Moll","full_name":"Moll, Wiebe"},{"first_name":"Michiel","full_name":"Coesmans, Michiel","last_name":"Coesmans"},{"last_name":"Jaarsma","full_name":"Jaarsma, Dick","first_name":"Dick"},{"last_name":"Henzen Logmans","full_name":"Henzen Logmans, Sonja","first_name":"Sonja"},{"full_name":"Vecht, Charles","last_name":"Vecht","first_name":"Charles"},{"full_name":"De Zeeuw, Chris","last_name":"De Zeeuw","first_name":"Chris"},{"last_name":"Sekiyama","full_name":"Sekiyama, Naotaka","first_name":"Naotaka"},{"full_name":"Nakanishi, Shigetada","last_name":"Nakanishi","first_name":"Shigetada"},{"last_name":"Shigemoto","orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"}],"doi":"10.1056/NEJM200001063420104","oa_version":"None","publisher":"Massachussetts Medical Society","day":"06","publist_id":"4300","abstract":[{"lang":"eng","text":"There are many types of cerebellar ataxia, including ataxia due to congenital or metabolic disorders and a paraneoplastic form in patients with gynecologic cancer, breast cancer, lung cancer, or Hodgkin's disease.1 This paraneoplastic syndrome is the only type of cerebellar ataxia associated with autoantibodies against neuronal antigens. Often, the neuronal antigens are aberrantly expressed by the tumor cells.2-4 The antineuronal autoantibodies are believed to cause cerebellar ataxia, but this is unproved.5,6 In Hodgkin's disease, the lymphoma precedes the ataxia by months to years in 80 percent of patients, and ataxia often occurs during a prolonged complete remission.4 Among patients with this type of ataxia, 30 percent have anti–Purkinje-cell antibodies, some of which have the features of the neuronal antibody anti-Tr.4,7\r\n\r\nWe identified a new autoantibody in two patients with severe cerebellar ataxia that developed while they were in remission from Hodgkin's disease. The antibody reacts specifically with the metabotropic glutamate receptor mGluR1 in mouse brain. Metabotropic glutamate receptors belong to a large family of cell-surface receptors that transmit signals into the cell by coupling to guanine nucleotide-binding proteins (G proteins) in the cytoplasm. Purified IgG from the serum of both patients blocked the glutamate-stimulated formation of inositol phosphates in Chinese-hamster-ovary (CHO) cells that expressed mGluR1α, and the injection of IgG from serum or cerebrospinal fluid into the cerebellar subarachnoid space of mice caused severe, reversible ataxia. These results indicate that antineuronal autoantibodies can cause disease of the central nervous system by blocking neuronal receptors."}],"publication_status":"published","status":"public","pmid":1,"language":[{"iso":"eng"}],"quality_controlled":"1","type":"journal_article","citation":{"mla":"Sillevis Smitt, Peter, et al. “Paraneoplastic Cerebellar Ataxia Due to Autoantibodies against a Glutamate Receptor.” <i>New England Journal of Medicine</i>, vol. 342, no. 1, Massachussetts Medical Society, 2000, pp. 21–27, doi:<a href=\"https://doi.org/10.1056/NEJM200001063420104\">10.1056/NEJM200001063420104</a>.","ista":"Sillevis Smitt P, Kinoshita A, De Leeuw B, Moll W, Coesmans M, Jaarsma D, Henzen Logmans S, Vecht C, De Zeeuw C, Sekiyama N, Nakanishi S, Shigemoto R. 2000. Paraneoplastic cerebellar ataxia due to autoantibodies against a glutamate receptor. New England Journal of Medicine. 342(1), 21–27.","chicago":"Sillevis Smitt, Peter, Ayae Kinoshita, Bertie De Leeuw, Wiebe Moll, Michiel Coesmans, Dick Jaarsma, Sonja Henzen Logmans, et al. “Paraneoplastic Cerebellar Ataxia Due to Autoantibodies against a Glutamate Receptor.” <i>New England Journal of Medicine</i>. Massachussetts Medical Society, 2000. <a href=\"https://doi.org/10.1056/NEJM200001063420104\">https://doi.org/10.1056/NEJM200001063420104</a>.","ama":"Sillevis Smitt P, Kinoshita A, De Leeuw B, et al. Paraneoplastic cerebellar ataxia due to autoantibodies against a glutamate receptor. <i>New England Journal of Medicine</i>. 2000;342(1):21-27. doi:<a href=\"https://doi.org/10.1056/NEJM200001063420104\">10.1056/NEJM200001063420104</a>","ieee":"P. Sillevis Smitt <i>et al.</i>, “Paraneoplastic cerebellar ataxia due to autoantibodies against a glutamate receptor,” <i>New England Journal of Medicine</i>, vol. 342, no. 1. Massachussetts Medical Society, pp. 21–27, 2000.","apa":"Sillevis Smitt, P., Kinoshita, A., De Leeuw, B., Moll, W., Coesmans, M., Jaarsma, D., … Shigemoto, R. (2000). Paraneoplastic cerebellar ataxia due to autoantibodies against a glutamate receptor. <i>New England Journal of Medicine</i>. Massachussetts Medical Society. <a href=\"https://doi.org/10.1056/NEJM200001063420104\">https://doi.org/10.1056/NEJM200001063420104</a>","short":"P. Sillevis Smitt, A. Kinoshita, B. De Leeuw, W. Moll, M. Coesmans, D. Jaarsma, S. Henzen Logmans, C. Vecht, C. De Zeeuw, N. Sekiyama, S. Nakanishi, R. Shigemoto, New England Journal of Medicine 342 (2000) 21–27."},"article_type":"original"},{"status":"public","pmid":1,"language":[{"iso":"eng"}],"publist_id":"4299","abstract":[{"lang":"eng","text":"The synaptic relationship between substance P (SP) and its receptor, i.e., neurokinin-1 receptor (NK1R), was examined in the striatum of the rat by confocal laser-scanning microscopy and electron microscopy. For confocal laser-scanning microscopy, triple-immunofluorescence histochemistry was performed to label NK1R, SP, and vesicular acetylcholine transporter (a specific marker for cholinergic neurons). In electron microscopic double- immunolabeling study, immunoreactivity for NK1R was detected with the silver- intensified gold method, while immunoreactivity for SP was detected with peroxidase immunohistochemistry. Simultaneous immunolabeling of NK1R and SP revealed significant mismatch at the synaptic level: although some SP- immunopositive axon terminals were in synaptic contact with NK1R- immunopositive sites of plasma membrane, NK1R-immunoreactivity was observed at both synaptic and non-synaptic sites of plasma membrane. Thus, SP released from the sites remote from NK1Rs might diffuse in the extracellular fluid to act, as a paracrine neurotransmitter, on NK1Rs distant from its releasing site. SP neurotransmission in the striatum might occur not only synaptically but also extrasynaptically. The SP-NK1R system might constitute an association system within the striatum."}],"publication_status":"published","quality_controlled":"1","type":"journal_article","citation":{"short":"J. Li, D. Wang, T. Kaneko, R. Shigemoto, S. Nomura, N. Mizuno, Journal of Comparative Neurology 418 (2000) 156–163.","apa":"Li, J., Wang, D., Kaneko, T., Shigemoto, R., Nomura, S., &#38; Mizuno, N. (2000). Relationship between neurokinin-1 receptor and substance P in the striatum: Light and electron microscopic immunohistochemical study in the rat. <i>Journal of Comparative Neurology</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1002/(SICI)1096-9861(20000306)418:2&#38;lt;156::AID-CNE3&#38;gt;3.0.CO;2-Z\">https://doi.org/10.1002/(SICI)1096-9861(20000306)418:2&#38;lt;156::AID-CNE3&#38;gt;3.0.CO;2-Z</a>","ieee":"J. Li, D. Wang, T. Kaneko, R. Shigemoto, S. Nomura, and N. Mizuno, “Relationship between neurokinin-1 receptor and substance P in the striatum: Light and electron microscopic immunohistochemical study in the rat,” <i>Journal of Comparative Neurology</i>, vol. 418, no. 2. Wiley-Blackwell, pp. 156–163, 2000.","chicago":"Li, Jin, Dan Wang, Takeshi Kaneko, Ryuichi Shigemoto, Sakashi Nomura, and Noboru Mizuno. “Relationship between Neurokinin-1 Receptor and Substance P in the Striatum: Light and Electron Microscopic Immunohistochemical Study in the Rat.” <i>Journal of Comparative Neurology</i>. Wiley-Blackwell, 2000. <a href=\"https://doi.org/10.1002/(SICI)1096-9861(20000306)418:2&#38;lt;156::AID-CNE3&#38;gt;3.0.CO;2-Z\">https://doi.org/10.1002/(SICI)1096-9861(20000306)418:2&#38;lt;156::AID-CNE3&#38;gt;3.0.CO;2-Z</a>.","ama":"Li J, Wang D, Kaneko T, Shigemoto R, Nomura S, Mizuno N. Relationship between neurokinin-1 receptor and substance P in the striatum: Light and electron microscopic immunohistochemical study in the rat. <i>Journal of Comparative Neurology</i>. 2000;418(2):156-163. doi:<a href=\"https://doi.org/10.1002/(SICI)1096-9861(20000306)418:2&#38;lt;156::AID-CNE3&#38;gt;3.0.CO;2-Z\">10.1002/(SICI)1096-9861(20000306)418:2&#38;lt;156::AID-CNE3&#38;gt;3.0.CO;2-Z</a>","ista":"Li J, Wang D, Kaneko T, Shigemoto R, Nomura S, Mizuno N. 2000. Relationship between neurokinin-1 receptor and substance P in the striatum: Light and electron microscopic immunohistochemical study in the rat. Journal of Comparative Neurology. 418(2), 156–163.","mla":"Li, Jin, et al. “Relationship between Neurokinin-1 Receptor and Substance P in the Striatum: Light and Electron Microscopic Immunohistochemical Study in the Rat.” <i>Journal of Comparative Neurology</i>, vol. 418, no. 2, Wiley-Blackwell, 2000, pp. 156–63, doi:<a href=\"https://doi.org/10.1002/(SICI)1096-9861(20000306)418:2&#38;lt;156::AID-CNE3&#38;gt;3.0.CO;2-Z\">10.1002/(SICI)1096-9861(20000306)418:2&#38;lt;156::AID-CNE3&#38;gt;3.0.CO;2-Z</a>."},"article_type":"original","publication_identifier":{"issn":["0021-9967"]},"year":"2000","author":[{"last_name":"Li","full_name":"Li, Jin","first_name":"Jin"},{"full_name":"Wang, Dan","last_name":"Wang","first_name":"Dan"},{"first_name":"Takeshi","full_name":"Kaneko, Takeshi","last_name":"Kaneko"},{"last_name":"Shigemoto","orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Nomura","full_name":"Nomura, Sakashi","first_name":"Sakashi"},{"last_name":"Mizuno","full_name":"Mizuno, Noboru","first_name":"Noboru"}],"oa_version":"None","doi":"10.1002/(SICI)1096-9861(20000306)418:2&lt;156::AID-CNE3&gt;3.0.CO;2-Z","day":"06","publisher":"Wiley-Blackwell","volume":418,"intvolume":"       418","acknowledgement":"The  authors  are  grateful  for  the  photographic  help  of Ms.  Yue-Ping  Yuan,  Mr.  Akira  Uesugi,  Ms.  Keiko  Oka-moto, Mr. Nobuyuki Kobayashi, and Mr. Hideki Itabashi. The authors also express their gratitudes for the support of Dr. Kajitaro Morita in Morita Clinic of Internal Medicine and Pediatrics, Kadoma, Osaka, Japan","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","issue":"2","extern":"1","scopus_import":"1","month":"03","title":"Relationship between neurokinin-1 receptor and substance P in the striatum: Light and electron microscopic immunohistochemical study in the rat","date_updated":"2023-05-03T10:56:44Z","article_processing_charge":"No","date_published":"2000-03-06T00:00:00Z","page":"156 - 163","publication":"Journal of Comparative Neurology","external_id":{"pmid":["10701441"]},"date_created":"2018-12-11T11:58:36Z","_id":"2599"}]