[{"publication_status":"published","status":"public","acknowledgement":"We thank many colleagues who provided reagents that enabled us to test axin1 and several other genes as candidates for the mbl mutation. In particular, we are indebted to Masahiko Hibi, Ken Irvine, Antonio Jacinto, Yun-Jin Jiang, Julian Lewis, and Tom Vogt for help and advice. We thank Ajay Chitnis and Dana Zivkovic for providing information prior to publication. This study was supported primarily by grants from the EMBO and EC to C.P.H., Wellcome Trust and EC to S.W.W., from the MRC to D.S., from Naito to M.T., from the DHGP to G.J.R. and R.G., and from the CRC/ICR to T.D. P.C. was supported by a PhD studentship from Fundação para a Ciência e Tecnologia, Programa PRAXIS XXI. S.W.W. is a Wellcome Trust Senior Research Fellow.\r\n\r\nThe publication costs of this article were defrayed in part by payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 USC section 1734 solely to indicate this fact.","publication_identifier":{"issn":["0890-9369"]},"abstract":[{"text":"Zebrafish embryos homozygous for the masterblind (mb1) mutation exhibit a striking phenotype in which the eyes and telencephalon are reduced or absent and diencephalic fates expand to the front of the brain. Here we show that mb1(-/-) embryos carry an amino-acid change at a conserved site in the Wnt pathway scaffolding protein, Axin1. The amino-acid substitution present in the mbl allele abolishes the binding of Axin to Gsk3 and affects Tcf-dependent transcription. Therefore, Gsk3 activity may be decreased in mbl(-/-) embryos and in support of this possibility, overexpression of either wild-type Axin1 or Gsk3 beta can restore eye and telencephalic fates to mb1(-/-) embryos. Our data reveal a crucial role for Axin1-dependent inhibition of the Wnt pathway in the early regional subdivision of the anterior neural plate into telencephalic, diencephalic, and eye-forming territories.","lang":"eng"}],"issue":"11","doi":"10.1101/gad.194301","title":"A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon","author":[{"orcid":"0000-0002-0912-4566","last_name":"Heisenberg","full_name":"Heisenberg, Carl-Philipp J","first_name":"Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Houart, Corinne","last_name":"Houart","first_name":"Corinne"},{"first_name":"Masaya","full_name":"Take Uchi, Masaya","last_name":"Take Uchi"},{"first_name":"Gerd","last_name":"Rauch","full_name":"Rauch, Gerd"},{"first_name":"Neville","full_name":"Young, Neville","last_name":"Young"},{"first_name":"Pedro","last_name":"Coutinho","full_name":"Coutinho, Pedro"},{"full_name":"Masai, Ichiro","last_name":"Masai","first_name":"Ichiro"},{"last_name":"Caneparo","full_name":"Caneparo, Luca","first_name":"Luca"},{"last_name":"Concha","full_name":"Concha, Miguel","first_name":"Miguel"},{"last_name":"Geisler","full_name":"Geisler, Robert","first_name":"Robert"},{"first_name":"Trevor","full_name":"Dale, Trevor","last_name":"Dale"},{"full_name":"Wilson, Stephen","last_name":"Wilson","first_name":"Stephen"},{"last_name":"Stemple","full_name":"Stemple, Derek","first_name":"Derek"}],"_id":"4200","article_processing_charge":"No","volume":15,"oa_version":"Published Version","citation":{"mla":"Heisenberg, Carl-Philipp J., et al. “A Mutation in the Gsk3-Binding Domain of Zebrafish Masterblind/Axin1 Leads to a Fate Transformation of Telencephalon and Eyes to Diencephalon.” Genes and Development, vol. 15, no. 11, Cold Spring Harbor Laboratory Press, 2001, pp. 1427–34, doi:10.1101/gad.194301.","chicago":"Heisenberg, Carl-Philipp J, Corinne Houart, Masaya Take Uchi, Gerd Rauch, Neville Young, Pedro Coutinho, Ichiro Masai, et al. “A Mutation in the Gsk3-Binding Domain of Zebrafish Masterblind/Axin1 Leads to a Fate Transformation of Telencephalon and Eyes to Diencephalon.” Genes and Development. Cold Spring Harbor Laboratory Press, 2001. https://doi.org/10.1101/gad.194301.","apa":"Heisenberg, C.-P. J., Houart, C., Take Uchi, M., Rauch, G., Young, N., Coutinho, P., … Stemple, D. (2001). A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon. Genes and Development. Cold Spring Harbor Laboratory Press. https://doi.org/10.1101/gad.194301","ieee":"C.-P. J. Heisenberg et al., “A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon,” Genes and Development, vol. 15, no. 11. Cold Spring Harbor Laboratory Press, pp. 1427–1434, 2001.","ama":"Heisenberg C-PJ, Houart C, Take Uchi M, et al. A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon. Genes and Development. 2001;15(11):1427-1434. doi:10.1101/gad.194301","short":"C.-P.J. Heisenberg, C. Houart, M. Take Uchi, G. Rauch, N. Young, P. Coutinho, I. Masai, L. Caneparo, M. Concha, R. Geisler, T. Dale, S. Wilson, D. Stemple, Genes and Development 15 (2001) 1427–1434.","ista":"Heisenberg C-PJ, Houart C, Take Uchi M, Rauch G, Young N, Coutinho P, Masai I, Caneparo L, Concha M, Geisler R, Dale T, Wilson S, Stemple D. 2001. A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon. Genes and Development. 15(11), 1427–1434."},"day":"01","pmid":1,"month":"06","page":"1427 - 1434","article_type":"original","publication":"Genes and Development","date_updated":"2023-05-10T12:27:02Z","year":"2001","oa":1,"quality_controlled":"1","type":"journal_article","language":[{"iso":"eng"}],"publisher":"Cold Spring Harbor Laboratory Press","main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC312705/"}],"intvolume":" 15","date_published":"2001-06-01T00:00:00Z","external_id":{"pmid":["11390362"]},"extern":"1","date_created":"2018-12-11T12:07:33Z","publist_id":"1916","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17"},{"author":[{"orcid":"0000-0002-4624-4612","full_name":"Bollback, Jonathan P","last_name":"Bollback","id":"2C6FA9CC-F248-11E8-B48F-1D18A9856A87","first_name":"Jonathan P"},{"first_name":"John","last_name":"Huelsenbeck","full_name":"Huelsenbeck, John"}],"title":"Phylogeny, genome evolution, and host specificity of single-stranded RNA bacteriophage (Family Leviviridae)","_id":"4229","issue":"2","abstract":[{"lang":"eng","text":"Bacteriophage of the family Leviviridae have played an important role in molecular biology where representative species, such as Qβ and MS2, have been studied as model systems for replication, translation, and the role of secondary structure in gene regulation. Using nucleotide sequences from the coat and replicase genes we present the first statistical estimate of phylogeny for the family Leviviridae using maximum-likelihood and Bayesian estimation. Our analyses reveal that the coliphage species are a monophyletic group consisting of two clades representing the genera Levivirus and Allolevivirus. The Pseudomonas species PP7 diverged from its common ancestor with the coliphage prior to the ancient split between these genera and their subsequent diversification. Differences in genome size, gene composition, and gene expression are shown with a high probability to have changed along the lineage leading to the Allolevivirus through gene expansion. The change in genome size of the Allolevivirus ancestor may have catalyzed subsequent changes that led to their current genome organization and gene expression."}],"doi":"10.1007/s002390010140","publication_identifier":{"issn":["0022-2844"]},"status":"public","acknowledgement":"We thank Kenneth G. Karol, Andrea J. Betancourt, Daven C. Presgraves, and Bret Larget for helpful comments and\r\nsuggestions. This work was supported by funding from the National Science Foundation (MCB-0075404 and DEB-0075406) to J.P.H.","publication_status":"published","day":"01","citation":{"chicago":"Bollback, Jonathan P, and John Huelsenbeck. “Phylogeny, Genome Evolution, and Host Specificity of Single-Stranded RNA Bacteriophage (Family Leviviridae).” Journal of Molecular Evolution. Springer, 2001. https://doi.org/10.1007/s002390010140.","mla":"Bollback, Jonathan P., and John Huelsenbeck. “Phylogeny, Genome Evolution, and Host Specificity of Single-Stranded RNA Bacteriophage (Family Leviviridae).” Journal of Molecular Evolution, vol. 52, no. 2, Springer, 2001, pp. 117–28, doi:10.1007/s002390010140.","ista":"Bollback JP, Huelsenbeck J. 2001. Phylogeny, genome evolution, and host specificity of single-stranded RNA bacteriophage (Family Leviviridae). Journal of Molecular Evolution. 52(2), 117–128.","ama":"Bollback JP, Huelsenbeck J. Phylogeny, genome evolution, and host specificity of single-stranded RNA bacteriophage (Family Leviviridae). Journal of Molecular Evolution. 2001;52(2):117-128. doi:10.1007/s002390010140","short":"J.P. Bollback, J. Huelsenbeck, Journal of Molecular Evolution 52 (2001) 117–128.","ieee":"J. P. Bollback and J. Huelsenbeck, “Phylogeny, genome evolution, and host specificity of single-stranded RNA bacteriophage (Family Leviviridae),” Journal of Molecular Evolution, vol. 52, no. 2. Springer, pp. 117–128, 2001.","apa":"Bollback, J. P., & Huelsenbeck, J. (2001). Phylogeny, genome evolution, and host specificity of single-stranded RNA bacteriophage (Family Leviviridae). Journal of Molecular Evolution. Springer. https://doi.org/10.1007/s002390010140"},"month":"02","pmid":1,"oa_version":"None","article_processing_charge":"No","volume":52,"year":"2001","publication":"Journal of Molecular Evolution","date_updated":"2023-05-10T12:23:49Z","article_type":"original","page":"117 - 128","publist_id":"1886","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_published":"2001-02-01T00:00:00Z","extern":"1","external_id":{"pmid":["11231891"]},"date_created":"2018-12-11T12:07:43Z","intvolume":" 52","publisher":"Springer","language":[{"iso":"eng"}],"quality_controlled":"1","type":"journal_article"},{"publication_identifier":{"issn":["0169-5347"]},"publication_status":"published","status":"public","acknowledgement":"We thank D. Bolnick, B. Fitzpatrick, S. Gavrilets, R. Haygood, C.D. Jones, M. Kirkpatrick, A. Kondrashov, J.B. Mullet, S.V. Nuzhdin, H.A. Orr, T.D. Price, T. Prout, D.W. Schemske, D. Schluter, M.R. Servedio and P.S. Ward for discussion and comments. Some of these reviewers disagree with our conclusions. This work was supported by US National Science Foundation grants DEB 9527808 and DEB 0089716 to MT, grants from the Darwin Trust of Edinburgh and the Biotechnology and Biological Sciences Research Council (GRJ/76057, GR/H/09928) to NHB, and National Institutes of Health grant R01 GM58260 to JAC. ","author":[{"first_name":"Michael","last_name":"Turelli","full_name":"Turelli, Michael"},{"orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H","last_name":"Barton","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","first_name":"Nicholas H"},{"first_name":"Jerry","last_name":"Coyne","full_name":"Coyne, Jerry"}],"title":"Theory and speciation","_id":"4264","issue":"7","abstract":[{"lang":"eng","text":"The study of speciation has become one of the most active areas of evolutionary biology, and substantial progress has been made in documenting and understanding phenomena ranging from sympatric speciation and reinforcement to the evolutionary genetics of postzygotic isolation. This progress has been driven largely by empirical results, and most useful theoretical work has concentrated on making sense of empirical patterns. Given the complexity of speciation, mathematical theory is subordinate to verbal theory and generalizations about data. Nevertheless, mathematical theory can provide a useful classification of verbal theories; can help determine the biological plausibility of verbal theories; can determine whether alternative mechanisms of speciation are consistent with empirical patterns; and can occasionally provide predictions that go beyond empirical generalizations. We discuss recent examples of progress in each of these areas."}],"doi":"10.1016/S0169-5347(01)02177-2","volume":16,"article_processing_charge":"No","day":"01","citation":{"ista":"Turelli M, Barton NH, Coyne J. 2001. Theory and speciation. Trends in Ecology and Evolution. 16(7), 330–343.","ama":"Turelli M, Barton NH, Coyne J. Theory and speciation. Trends in Ecology and Evolution. 2001;16(7):330-343. doi:10.1016/S0169-5347(01)02177-2","short":"M. Turelli, N.H. Barton, J. Coyne, Trends in Ecology and Evolution 16 (2001) 330–343.","apa":"Turelli, M., Barton, N. H., & Coyne, J. (2001). Theory and speciation. Trends in Ecology and Evolution. Cell Press. https://doi.org/10.1016/S0169-5347(01)02177-2","ieee":"M. Turelli, N. H. Barton, and J. Coyne, “Theory and speciation,” Trends in Ecology and Evolution, vol. 16, no. 7. Cell Press, pp. 330–343, 2001.","mla":"Turelli, Michael, et al. “Theory and Speciation.” Trends in Ecology and Evolution, vol. 16, no. 7, Cell Press, 2001, pp. 330–43, doi:10.1016/S0169-5347(01)02177-2.","chicago":"Turelli, Michael, Nicholas H Barton, and Jerry Coyne. “Theory and Speciation.” Trends in Ecology and Evolution. Cell Press, 2001. https://doi.org/10.1016/S0169-5347(01)02177-2."},"month":"07","pmid":1,"oa_version":"None","publication":"Trends in Ecology and Evolution","date_updated":"2023-05-10T12:16:55Z","article_type":"original","page":"330 - 343","year":"2001","intvolume":" 16","publisher":"Cell Press","quality_controlled":"1","type":"journal_article","language":[{"iso":"eng"}],"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publist_id":"1828","external_id":{"pmid":["11403865"]},"date_published":"2001-07-01T00:00:00Z","extern":"1","date_created":"2018-12-11T12:07:55Z"},{"year":"2001","article_type":"original","page":"1921 - 1931","date_updated":"2023-05-10T12:12:32Z","publication":"Evolution; International Journal of Organic Evolution","scopus_import":"1","date_created":"2018-12-11T12:07:56Z","external_id":{"pmid":["11761054"]},"extern":"1","date_published":"2001-10-01T00:00:00Z","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publist_id":"1827","quality_controlled":"1","language":[{"iso":"eng"}],"type":"journal_article","intvolume":" 55","publisher":"Wiley-Blackwell","doi":"10.1111/j.0014-3820.2001.tb01310.x","issue":"10","abstract":[{"lang":"eng","text":"The reasons that sex and recombination are so widespread remain elusive. One popular hypothesis is that sex and recombination promote adaptation to a changing environment. The strongest evidence that increased recombination may evolve because recombination promotes adaptation comes from artificially selected populations. Recombination rates have been found to increase as a correlated response to selection on traits unrelated to recombination in several artificial selection experiments and in a comparison of domesticated and nondomesticated mammals. There are, however, several alternative explanations for the increase in recombination in such populations, including two different evolutionary explanations. The first is that the form of selection is epistatic, generating linkage disequilibria among selected loci, which can indirectly favor modifier alleles that increase recombination. The second is that random genetic drift in selected populations tends to generate disequilibria such that beneficial alleles are often found in different individuals; modifier alleles that increase recombination can bring together such favorable alleles and thus may be found in individuals with greater fitness. In this paper, we compare the evolutionary forces acting on recombination in finite populations subject to strong selection, To our surprise, we found that drift accounted for the majority of selection for increased recombination observed in simulations of small to moderately large populations, suggesting that, unless selected populations are large, epistasis plays a secondary role in the evolution of recombination."}],"_id":"4265","author":[{"full_name":"Otto, Sarah","last_name":"Otto","first_name":"Sarah"},{"orcid":"0000-0002-8548-5240","last_name":"Barton","full_name":"Barton, Nicholas H","first_name":"Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87"}],"title":"Selection for recombination in small populations","status":"public","publication_status":"published","acknowledgement":"We are grateful to P. Awadalla, T. Lenormand, A. Peters, S. West, M. Whitlock, and two anonymous reviewers for helpful comments on the manuscript. Funding was provided by the Natural Sciences and Engineering Research Council\r\n(Canada) to SPO, the Centre National de la Recherche Scientifique (France) to SPO, the Darwin Trust of Edinburgh to\r\nNHB, and the BBSRC (U.K.) to NHB. ","publication_identifier":{"issn":["0014-3820"]},"oa_version":"None","pmid":1,"month":"10","day":"01","citation":{"mla":"Otto, Sarah, and Nicholas H. Barton. “Selection for Recombination in Small Populations.” Evolution; International Journal of Organic Evolution, vol. 55, no. 10, Wiley-Blackwell, 2001, pp. 1921–31, doi:10.1111/j.0014-3820.2001.tb01310.x.","chicago":"Otto, Sarah, and Nicholas H Barton. “Selection for Recombination in Small Populations.” Evolution; International Journal of Organic Evolution. Wiley-Blackwell, 2001. https://doi.org/10.1111/j.0014-3820.2001.tb01310.x.","short":"S. Otto, N.H. Barton, Evolution; International Journal of Organic Evolution 55 (2001) 1921–1931.","ama":"Otto S, Barton NH. Selection for recombination in small populations. Evolution; International Journal of Organic Evolution. 2001;55(10):1921-1931. doi:10.1111/j.0014-3820.2001.tb01310.x","ista":"Otto S, Barton NH. 2001. Selection for recombination in small populations. Evolution; International Journal of Organic Evolution. 55(10), 1921–1931.","ieee":"S. Otto and N. H. Barton, “Selection for recombination in small populations,” Evolution; International Journal of Organic Evolution, vol. 55, no. 10. Wiley-Blackwell, pp. 1921–1931, 2001.","apa":"Otto, S., & Barton, N. H. (2001). Selection for recombination in small populations. Evolution; International Journal of Organic Evolution. Wiley-Blackwell. https://doi.org/10.1111/j.0014-3820.2001.tb01310.x"},"article_processing_charge":"No","volume":55},{"extern":"1","date_published":"2001-03-01T00:00:00Z","external_id":{"pmid":["11298968"]},"date_created":"2018-12-11T12:07:56Z","scopus_import":"1","publist_id":"1824","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","quality_controlled":"1","type":"journal_article","language":[{"iso":"eng"}],"publisher":"Wiley-Blackwell","intvolume":" 10","year":"2001","page":"551 - 568","article_type":"original","publication":"Molecular Ecology","date_updated":"2023-05-10T11:45:07Z","oa_version":"None","citation":{"ista":"Barton NH. 2001. The role of hybridization in evolution. Molecular Ecology. 10(3), 551–568.","short":"N.H. Barton, Molecular Ecology 10 (2001) 551–568.","ama":"Barton NH. The role of hybridization in evolution. Molecular Ecology. 2001;10(3):551-568. doi:10.1046/j.1365-294X.2001.01216.x","apa":"Barton, N. H. (2001). The role of hybridization in evolution. Molecular Ecology. Wiley-Blackwell. https://doi.org/10.1046/j.1365-294X.2001.01216.x","ieee":"N. H. Barton, “The role of hybridization in evolution,” Molecular Ecology, vol. 10, no. 3. Wiley-Blackwell, pp. 551–568, 2001.","mla":"Barton, Nicholas H. “The Role of Hybridization in Evolution.” Molecular Ecology, vol. 10, no. 3, Wiley-Blackwell, 2001, pp. 551–68, doi:10.1046/j.1365-294X.2001.01216.x.","chicago":"Barton, Nicholas H. “The Role of Hybridization in Evolution.” Molecular Ecology. Wiley-Blackwell, 2001. https://doi.org/10.1046/j.1365-294X.2001.01216.x."},"day":"01","pmid":1,"month":"03","article_processing_charge":"No","volume":10,"abstract":[{"text":"Hybridization may influence evolution in a variety of ways. If hybrids are less fit, the geographical range of ecologically divergent populations may be limited, and prezygotic reproductive isolation may be reinforced. If some hybrid genotypes are fitter than one or both parents, at least in some environments, then hybridization could make a positive contribution. Single alleles that are at an advantage in the alternative environment and genetic background will introgress readily, although such introgression may be hard to detect. 'Hybrid speciation', in which fit combinations of alleles are established, is more problematic; its likelihood depends on how divergent populations meet, and on the structure of epistasis. These issues are illustrated using Fisher's model of stabilizing selection on multiple traits, under which reproductive isolation evolves as a side-effect of adaptation in allopatry. This confirms a priori arguments that while recombinant hybrids are less fit on average, some gene combinations may be fitter than the parents, even in the parental environment. Fisher's model does predict heterosis in diploid F1s, asymmetric incompatibility in reciprocal backcrosses, and (when dominance is included) Haldane's Rule. However, heterosis arises only when traits are additive, whereas the latter two patterns require dominance. Moreover, because adaptation is via substitutions of small effect, Fisher's model does not generate the strong effects of single chromosome regions often observed in species crosses.","lang":"eng"}],"issue":"3","doi":"10.1046/j.1365-294X.2001.01216.x","title":"The role of hybridization in evolution","author":[{"orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H","last_name":"Barton","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","first_name":"Nicholas H"}],"_id":"4266","status":"public","publication_status":"published","acknowledgement":"This work was supported by the Darwin Trust of Edinburgh and by grant GR3/11635 from the Natural Environment Research Council. I would like to thank Loren Rieseberg, Allen Orr, Michael Turelli, and an anonymous referee for their helpful comments","publication_identifier":{"issn":["962-1083"]}},{"main_file_link":[{"url":"https://www.cambridge.org/us/academic/subjects/life-sciences/ecology-and-conservation/integrating-ecology-and-evolution-spatial-context-14th-special-symposium-british-ecological-society?format=HB&isbn=9780521840002"}],"publisher":"Cambridge University Press","type":"book_chapter","quality_controlled":"1","language":[{"iso":"eng"}],"article_processing_charge":"No","publist_id":"1825","month":"08","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","day":"01","citation":{"chicago":"Barton, Nicholas H. “Adaptation at the Edge of a Species’ Range.” In Integrating Ecology and Evolution in a Spatial Context, 365–92. Cambridge University Press, 2001.","mla":"Barton, Nicholas H. “Adaptation at the Edge of a Species’ Range.” Integrating Ecology and Evolution in a Spatial Context, Cambridge University Press, 2001, pp. 365–92.","apa":"Barton, N. H. (2001). Adaptation at the edge of a species’ range. In Integrating ecology and evolution in a spatial context (pp. 365–392). Cambridge University Press.","ieee":"N. H. Barton, “Adaptation at the edge of a species’ range,” in Integrating ecology and evolution in a spatial context, Cambridge University Press, 2001, pp. 365–392.","ista":"Barton NH. 2001.Adaptation at the edge of a species’ range. In: Integrating ecology and evolution in a spatial context. , 365–392.","short":"N.H. Barton, in:, Integrating Ecology and Evolution in a Spatial Context, Cambridge University Press, 2001, pp. 365–392.","ama":"Barton NH. Adaptation at the edge of a species’ range. In: Integrating Ecology and Evolution in a Spatial Context. Cambridge University Press; 2001:365-392."},"date_created":"2018-12-11T12:07:57Z","oa_version":"None","date_published":"2001-08-01T00:00:00Z","extern":"1","date_updated":"2023-05-10T11:59:06Z","publication":"Integrating ecology and evolution in a spatial context","publication_identifier":{"isbn":["9780521840002"]},"page":"365 - 392","publication_status":"published","status":"public","_id":"4267","author":[{"first_name":"Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","last_name":"Barton","full_name":"Barton, Nicholas H","orcid":"0000-0002-8548-5240"}],"title":"Adaptation at the edge of a species' range","year":"2001","abstract":[{"text":"The flow of genes from the dense and well-adapted centre of a species' distribution interferes with adaptation to marginal environments, and may sharply limit a species' range. Deterministic models of a linear habitat suggest that populations could in principle adapt to very steep environmental gradients, by increasing their genetic variability. However, random fluctuations in sparse populations reduce this variance, and may be crucial in limiting the species' range.","lang":"eng"}]},{"status":"public","publication_status":"published","date_updated":"2023-05-10T09:57:10Z","publication":"Dispersal","publication_identifier":{"isbn":["9780198506591"]},"abstract":[{"text":"The ability of species to migrate that has interested ecologists for many years. Now that so many species and ecosystems face major environmental change, the ability of species to adapt to these changes by dispersing, migrating, or moving between different patches of habitat can be crucial to ensuring their survivial. This book provides a timely and wide-ranging overview of the study of dispersal and incorporates much of the latest research. The causes, mechanisms, and consequences of dispersal at the individual, population, species and community levels are considered. The potential of new techniques and models for studying dispersal, drawn from molecular biology and demography, is also explored. Perspectives and insights are offered from the fields of evolution, conservation biology and genetics. Throughout the book, theoretical approaches are combined with empirical data, and care has been taken to include examples from as wide a range of species as possible. ","lang":"eng"}],"year":"2001","_id":"4278","title":"The evolutionary consequences of gene flow and local adaptation: Future approaches","author":[{"full_name":"Barton, Nicholas H","last_name":"Barton","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","first_name":"Nicholas H","orcid":"0000-0002-8548-5240"}],"article_processing_charge":"No","type":"book_chapter","language":[{"iso":"eng"}],"quality_controlled":"1","publisher":"Oxford University Press","main_file_link":[{"url":"https://www.nhbs.com/dispersal-book"}],"date_created":"2018-12-11T12:08:00Z","oa_version":"None","extern":"1","date_published":"2001-04-01T00:00:00Z","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","month":"04","publist_id":"1812","citation":{"chicago":"Barton, Nicholas H. “The Evolutionary Consequences of Gene Flow and Local Adaptation: Future Approaches.” In Dispersal. Oxford University Press, 2001.","mla":"Barton, Nicholas H. “The Evolutionary Consequences of Gene Flow and Local Adaptation: Future Approaches.” Dispersal, Oxford University Press, 2001.","apa":"Barton, N. H. (2001). The evolutionary consequences of gene flow and local adaptation: Future approaches. In Dispersal. Oxford University Press.","ieee":"N. H. Barton, “The evolutionary consequences of gene flow and local adaptation: Future approaches,” in Dispersal, Oxford University Press, 2001.","ama":"Barton NH. The evolutionary consequences of gene flow and local adaptation: Future approaches. In: Dispersal. Oxford University Press; 2001.","short":"N.H. Barton, in:, Dispersal, Oxford University Press, 2001.","ista":"Barton NH. 2001.The evolutionary consequences of gene flow and local adaptation: Future approaches. In: Dispersal. ."},"day":"01"},{"citation":{"mla":"Henzinger, Thomas A., editor. EMSOFT: Embedded Software. Vol. 2211, ACM, 2001, doi:10.1007/3-540-45449-7.","chicago":"Henzinger, Thomas A, ed. EMSOFT: Embedded Software. Vol. 2211. ACM, 2001. https://doi.org/10.1007/3-540-45449-7.","ista":"Henzinger TA ed. 2001. EMSOFT: Embedded Software, ACM,p.","ama":"Henzinger TA, ed. EMSOFT: Embedded Software. Vol 2211. ACM; 2001. doi:10.1007/3-540-45449-7","short":"T.A. Henzinger, ed., EMSOFT: Embedded Software, ACM, 2001.","apa":"Henzinger, T. A. (Ed.). (2001). EMSOFT: Embedded Software (Vol. 2211). Presented at the EMSOFT 2001: Embedded Software, Tahoe City, CA, USA: ACM. https://doi.org/10.1007/3-540-45449-7","ieee":"T. A. Henzinger, Ed., EMSOFT: Embedded Software, vol. 2211. ACM, 2001."},"day":"26","publist_id":"283","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","month":"09","date_published":"2001-09-26T00:00:00Z","extern":"1","oa_version":"None","date_created":"2018-12-11T12:08:54Z","conference":{"name":"EMSOFT 2001: Embedded Software","end_date":"2001-10-10","start_date":"2001-10-08","location":"Tahoe City, CA, USA"},"publisher":"ACM","intvolume":" 2211","article_processing_charge":"No","volume":2211,"language":[{"iso":"eng"}],"type":"conference_editor","quality_controlled":"1","title":"EMSOFT: Embedded Software","_id":"4449","editor":[{"orcid":"0000-0002-2985-7724","id":"40876CD8-F248-11E8-B48F-1D18A9856A87","first_name":"Thomas A","full_name":"Henzinger, Thomas A","last_name":"Henzinger"}],"abstract":[{"text":"Embedded software is software that interacts with physical processes. As em- bedded systems increasingly permeate our daily lives on all levels, from micros- copic devices to international networks, the cost-efficient development of reliable embedded software is one of the grand challenges in computer science today. The purpose of the workshop is to bring together researchers in all areas of computer science that are traditionally distinct but relevant to embedded software develop- ment, and to incubate a research community in this way. The workshop aims to cover all aspects of the design and implementation of embedded software, inclu- ding operating systems and middleware, programming languages and compilers, modeling and validation, software engineering and programming methodologies, scheduling and execution time analysis, networking and fault tolerance, as well as application areas, such as embedded control, real-time signal processing, and telecommunications.","lang":"eng"}],"year":"2001","alternative_title":["LNCS"],"doi":"10.1007/3-540-45449-7","publication_identifier":{"isbn":["9783540426738"]},"date_updated":"2023-05-10T09:53:17Z","status":"public","publication_status":"published"},{"extern":"1","date_published":"2001-05-01T00:00:00Z","scopus_import":"1","conference":{"name":"CDC: Decision and Control","start_date":"2001-12-04","location":"Orlando, FL, USA","end_date":"2001-12-07"},"date_created":"2018-12-11T12:09:02Z","oa_version":"None","day":"01","citation":{"ista":"Henzinger TA, Preussig J, Wong Toi H. 2001. Some lessons from the HYTECH experience. Proceedings of the 40th IEEE Conference on Decision and Control. CDC: Decision and Control vol. 3, 2887–2892.","short":"T.A. Henzinger, J. Preussig, H. Wong Toi, in:, Proceedings of the 40th IEEE Conference on Decision and Control, IEEE, 2001, pp. 2887–2892.","ama":"Henzinger TA, Preussig J, Wong Toi H. Some lessons from the HYTECH experience. In: Proceedings of the 40th IEEE Conference on Decision and Control. Vol 3. IEEE; 2001:2887-2892. doi:10.1109/.2001.980714","apa":"Henzinger, T. A., Preussig, J., & Wong Toi, H. (2001). Some lessons from the HYTECH experience. In Proceedings of the 40th IEEE Conference on Decision and Control (Vol. 3, pp. 2887–2892). Orlando, FL, USA: IEEE. https://doi.org/10.1109/.2001.980714","ieee":"T. A. Henzinger, J. Preussig, and H. Wong Toi, “Some lessons from the HYTECH experience,” in Proceedings of the 40th IEEE Conference on Decision and Control, Orlando, FL, USA, 2001, vol. 3, pp. 2887–2892.","mla":"Henzinger, Thomas A., et al. “Some Lessons from the HYTECH Experience.” Proceedings of the 40th IEEE Conference on Decision and Control, vol. 3, IEEE, 2001, pp. 2887–92, doi:10.1109/.2001.980714.","chicago":"Henzinger, Thomas A, Joerg Preussig, and Howard Wong Toi. “Some Lessons from the HYTECH Experience.” In Proceedings of the 40th IEEE Conference on Decision and Control, 3:2887–92. IEEE, 2001. https://doi.org/10.1109/.2001.980714."},"month":"05","publist_id":"253","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","type":"conference","quality_controlled":"1","language":[{"iso":"eng"}],"article_processing_charge":"No","volume":3,"intvolume":" 3","publisher":"IEEE","year":"2001","abstract":[{"lang":"eng","text":"We provide an overview of the current status of HYTECH, and reflect on some of the lessons learned from our experiences with the tool. HYTECH is a symbolic model checker for mixed discrete-continuous systems that are modeled as automata with piecewise-constant polyhedral differential inclusions. The use of a formal input language and automated procedures for state-space traversal lay the foundation for formally verifying properties of hybrid dynamical systems. We describe some recent experiences analyzing three hybrid systems. We point out the successes and limitations of the tool. The analysis procedure has been extended in a number of ways to address some of the tool's shortcomings. We evaluate these extensions, and conclude with some desiderata for verification tools for hybrid systems."}],"doi":"10.1109/.2001.980714","author":[{"orcid":"0000−0002−2985−7724","last_name":"Henzinger","full_name":"Henzinger, Thomas A","first_name":"Thomas A","id":"40876CD8-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Preussig, Joerg","last_name":"Preussig","first_name":"Joerg"},{"first_name":"Howard","last_name":"Wong Toi","full_name":"Wong Toi, Howard"}],"title":"Some lessons from the HYTECH experience","_id":"4475","publication_status":"published","status":"public","page":"2887 - 2892","publication_identifier":{"isbn":["0780370619"]},"publication":"Proceedings of the 40th IEEE Conference on Decision and Control","date_updated":"2023-05-10T09:47:20Z"},{"article_processing_charge":"No","volume":2034,"oa_version":"None","conference":{"end_date":"2001-03-30","location":"Rome, Italy","start_date":"2001-03-28","name":"HSCC: Hybrid Systems - Computation and Control"},"month":"03","citation":{"apa":"Henzinger, T. A., Minea, M., & Prabhu, V. (2001). Assume-guarantee reasoning for hierarchical hybrid systems. In Proceedings of the 4th International Workshop on Hybrid Systems (Vol. 2034, pp. 275–290). Rome, Italy: Springer. https://doi.org/10.1007/3-540-45351-2_24","ieee":"T. A. Henzinger, M. Minea, and V. Prabhu, “Assume-guarantee reasoning for hierarchical hybrid systems,” in Proceedings of the 4th International Workshop on Hybrid Systems, Rome, Italy, 2001, vol. 2034, pp. 275–290.","ista":"Henzinger TA, Minea M, Prabhu V. 2001. Assume-guarantee reasoning for hierarchical hybrid systems. Proceedings of the 4th International Workshop on Hybrid Systems. HSCC: Hybrid Systems - Computation and Control, LNCS, vol. 2034, 275–290.","ama":"Henzinger TA, Minea M, Prabhu V. Assume-guarantee reasoning for hierarchical hybrid systems. In: Proceedings of the 4th International Workshop on Hybrid Systems. Vol 2034. Springer; 2001:275-290. doi:10.1007/3-540-45351-2_24","short":"T.A. Henzinger, M. Minea, V. Prabhu, in:, Proceedings of the 4th International Workshop on Hybrid Systems, Springer, 2001, pp. 275–290.","mla":"Henzinger, Thomas A., et al. “Assume-Guarantee Reasoning for Hierarchical Hybrid Systems.” Proceedings of the 4th International Workshop on Hybrid Systems, vol. 2034, Springer, 2001, pp. 275–90, doi:10.1007/3-540-45351-2_24.","chicago":"Henzinger, Thomas A, Marius Minea, and Vinayak Prabhu. “Assume-Guarantee Reasoning for Hierarchical Hybrid Systems.” In Proceedings of the 4th International Workshop on Hybrid Systems, 2034:275–90. Springer, 2001. https://doi.org/10.1007/3-540-45351-2_24."},"day":"14","publication_status":"published","acknowledgement":"Support for this research was provided in part by the AFOSR MURI grant F49620- 00-1-0327, and the DARPA SEC grant F33615-C-98-3614, the MARCO GSRC grant 98-DT-660, the NSF ITR grant CCR-0085949.","status":"public","publication_identifier":{"isbn":["9783540418665"]},"doi":"10.1007/3-540-45351-2_24","abstract":[{"lang":"eng","text":"The assume-guarantee paradigm is a powerful divide-and-conquer mechanism for decomposing a verification task about a system into subtasks about the individual components of the system. The key to assume-guarantee reasoning is to consider each component not in isolation, but in conjunction with assumptions about the context of the component. Assume-guarantee principles are known for purely concurrent contexts, which constrain the input data of a component, as well as for purely sequential contexts, which constrain the entry configurations of a component. We present a model for hierarchical system design which permits the arbitrary nesting of parallel as well as serial composition, and which supports an assume-guarantee principle for mixed parallel-serial contexts. Our model also supports both discrete and continuous processes, and is therefore well-suited for the modeling and analysis of embedded software systems which interact with real-world environments. Using an example of two cooperating robots, we show refinement between a high-level model which specifies continuous timing constraints and an implementation which relies on discrete sampling."}],"_id":"4477","title":"Assume-guarantee reasoning for hierarchical hybrid systems","author":[{"full_name":"Henzinger, Thomas A","last_name":"Henzinger","id":"40876CD8-F248-11E8-B48F-1D18A9856A87","first_name":"Thomas A","orcid":"0000−0002−2985−7724"},{"first_name":"Marius","full_name":"Minea, Marius","last_name":"Minea"},{"first_name":"Vinayak","last_name":"Prabhu","full_name":"Prabhu, Vinayak"}],"language":[{"iso":"eng"}],"type":"conference","quality_controlled":"1","publisher":"Springer","intvolume":" 2034","date_created":"2018-12-11T12:09:03Z","scopus_import":"1","date_published":"2001-03-14T00:00:00Z","extern":"1","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publist_id":"250","page":"275 - 290","date_updated":"2023-05-09T14:47:37Z","publication":"Proceedings of the 4th International Workshop on Hybrid Systems","alternative_title":["LNCS"],"year":"2001"},{"publisher":"ACM","type":"conference","quality_controlled":"1","language":[{"iso":"eng"}],"article_processing_charge":"No","month":"06","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publist_id":"251","day":"01","citation":{"mla":"Henzinger, Thomas A., et al. “Embedded Control Systems Development with Giotto.” Proceedings of the 2nd ACM SIGPLAN Workshop on Languages, Compilers and Tools for Embedded Systems, ACM, 2001, pp. 64–72, doi:10.1145/384197.384208.","chicago":"Henzinger, Thomas A, Benjamin Horowitz, and Christoph Kirsch. “Embedded Control Systems Development with Giotto.” In Proceedings of the 2nd ACM SIGPLAN Workshop on Languages, Compilers and Tools for Embedded Systems, 64–72. ACM, 2001. https://doi.org/10.1145/384197.384208.","short":"T.A. Henzinger, B. Horowitz, C. Kirsch, in:, Proceedings of the 2nd ACM SIGPLAN Workshop on Languages, Compilers and Tools for Embedded Systems, ACM, 2001, pp. 64–72.","ama":"Henzinger TA, Horowitz B, Kirsch C. Embedded control systems development with Giotto. In: Proceedings of the 2nd ACM SIGPLAN Workshop on Languages, Compilers and Tools for Embedded Systems. ACM; 2001:64-72. doi:10.1145/384197.384208","ista":"Henzinger TA, Horowitz B, Kirsch C. 2001. Embedded control systems development with Giotto. Proceedings of the 2nd ACM SIGPLAN workshop on Languages, compilers and tools for embedded systems. LCTES: Languages, Compilers, and Tools for Embedded Systems, 64–72.","ieee":"T. A. Henzinger, B. Horowitz, and C. Kirsch, “Embedded control systems development with Giotto,” in Proceedings of the 2nd ACM SIGPLAN workshop on Languages, compilers and tools for embedded systems, New York, NY, United States, 2001, pp. 64–72.","apa":"Henzinger, T. A., Horowitz, B., & Kirsch, C. (2001). Embedded control systems development with Giotto. In Proceedings of the 2nd ACM SIGPLAN workshop on Languages, compilers and tools for embedded systems (pp. 64–72). New York, NY, United States: ACM. https://doi.org/10.1145/384197.384208"},"conference":{"location":"New York, NY, United States","name":"LCTES: Languages, Compilers, and Tools for Embedded Systems"},"scopus_import":"1","oa_version":"None","date_created":"2018-12-11T12:09:03Z","extern":"1","date_published":"2001-06-01T00:00:00Z","date_updated":"2023-05-10T09:37:20Z","publication":"Proceedings of the 2nd ACM SIGPLAN workshop on Languages, compilers and tools for embedded systems","publication_identifier":{"isbn":["9781581134254"]},"page":"64 - 72","status":"public","publication_status":"published","acknowledgement":"We thank Rupak Majumdar for implementing a prototype Giotto compiler for Lego Mindstorms robots. We thank Dmitry Derevyanko and Winthrop Williams for building our Intel x86 robots. We thank Edward Lee and Xiaojun Liu for help with a Ptolemy II [4] implementation of Giotto. This research was supported in part by the DARPA SEC grant F33615-C-98-3614, the DARPA MoBIES grant F33615- 00-C-1703, the MARCO GSRC grant 98-DT-660, the AFOSR MURI grant F49620-00-1-0327, and the NSF ITR grant CCR-0085949.","_id":"4478","author":[{"full_name":"Henzinger, Thomas A","last_name":"Henzinger","id":"40876CD8-F248-11E8-B48F-1D18A9856A87","first_name":"Thomas A","orcid":"0000−0002−2985−7724"},{"first_name":"Benjamin","last_name":"Horowitz","full_name":"Horowitz, Benjamin"},{"first_name":"Christoph","last_name":"Kirsch","full_name":"Kirsch, Christoph"}],"title":"Embedded control systems development with Giotto","doi":"10.1145/384197.384208","year":"2001","abstract":[{"text":"Giotto is a principled, tool-supported design methodology for implementing embedded control systems on platforms of possibly distributed sensors, actuators, CPUs, and networks. Giotto is based on the principle that time-triggered task invocations plus time-triggered mode switches can form the abstract essence of programming real-time control systems. Giotto consists of a programming language with a formal semantics, and a retargetable compiler and runtime library. Giotto supports the automation of control system design by strictly separating platform-independent functionality and timing concerns from platform-dependent scheduling and communication issues. The time-triggered predictability of Giotto makes it particularly suitable for safety-critical applications with hard real-time constraints. We illustrate the platform-independence and time-triggered execution of Giotto by coordinating a heterogeneous flock of Intel x86 robots and Lego Mindstorms robots.","lang":"eng"}]},{"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publist_id":"252","date_published":"2001-09-26T00:00:00Z","extern":"1","scopus_import":"1","date_created":"2018-12-11T12:09:04Z","intvolume":" 2211","publisher":"ACM","type":"conference","quality_controlled":"1","language":[{"iso":"eng"}],"year":"2001","alternative_title":["LNCS"],"publication":"Proceedings of the 1st International Workshop on Embedded Software","date_updated":"2023-05-10T09:42:10Z","page":"166 - 184","day":"26","citation":{"mla":"Henzinger, Thomas A., et al. “Giotto: A Time-Triggered Language for Embedded Programming.” Proceedings of the 1st International Workshop on Embedded Software, vol. 2211, ACM, 2001, pp. 166–84, doi:10.1007/3-540-45449-7_12.","chicago":"Henzinger, Thomas A, Benjamin Horowitz, and Christoph Kirsch. “Giotto: A Time-Triggered Language for Embedded Programming.” In Proceedings of the 1st International Workshop on Embedded Software, 2211:166–84. ACM, 2001. https://doi.org/10.1007/3-540-45449-7_12.","short":"T.A. Henzinger, B. Horowitz, C. Kirsch, in:, Proceedings of the 1st International Workshop on Embedded Software, ACM, 2001, pp. 166–184.","ama":"Henzinger TA, Horowitz B, Kirsch C. Giotto: A time-triggered language for embedded programming. In: Proceedings of the 1st International Workshop on Embedded Software. Vol 2211. ACM; 2001:166-184. doi:10.1007/3-540-45449-7_12","ista":"Henzinger TA, Horowitz B, Kirsch C. 2001. Giotto: A time-triggered language for embedded programming. Proceedings of the 1st International Workshop on Embedded Software. EMSOFT: Embedded Software , LNCS, vol. 2211, 166–184.","apa":"Henzinger, T. A., Horowitz, B., & Kirsch, C. (2001). Giotto: A time-triggered language for embedded programming. In Proceedings of the 1st International Workshop on Embedded Software (Vol. 2211, pp. 166–184). Tahoe City, CA, USA: ACM. https://doi.org/10.1007/3-540-45449-7_12","ieee":"T. A. Henzinger, B. Horowitz, and C. Kirsch, “Giotto: A time-triggered language for embedded programming,” in Proceedings of the 1st International Workshop on Embedded Software, Tahoe City, CA, USA, 2001, vol. 2211, pp. 166–184."},"month":"09","conference":{"location":"Tahoe City, CA, USA","start_date":"2001-10-08","end_date":"2001-10-10","name":"EMSOFT: Embedded Software "},"oa_version":"None","article_processing_charge":"No","volume":2211,"author":[{"orcid":"0000−0002−2985−7724","last_name":"Henzinger","full_name":"Henzinger, Thomas A","first_name":"Thomas A","id":"40876CD8-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Horowitz","full_name":"Horowitz, Benjamin","first_name":"Benjamin"},{"first_name":"Christoph","last_name":"Kirsch","full_name":"Kirsch, Christoph"}],"title":"Giotto: A time-triggered language for embedded programming","_id":"4479","abstract":[{"text":"Giotto provides an abstract programmer’s model for the implementation of embedded control systems with hard real-time constraints. A typical control application consists of periodic software tasks together with a mode switching logic for enabling and disabling tasks. Giotto specifies time-triggered sensor readings, task invocations, and mode switches independent of any implementation platform. Giotto can be annotated with platform constraints such as task-to-host mappings, and task and communication schedules. The annotations are directives for the Giotto compiler, but they do not alter the functionality and timing of a Giotto program. By separating the platform-independent from the platform-dependent concerns, Giotto enables a great deal of flexibility in choosing control platforms as well as a great deal of automation in the validation and synthesis of control software. The time-triggered nature of Giotto achieves timing predictability, which makes Giotto particularly suitable for safety-critical applications.","lang":"eng"}],"doi":"10.1007/3-540-45449-7_12","publication_identifier":{"isbn":["9783540426738"]},"acknowledgement":"This research was supported in part by the DARPA SEC grant F33615-C-98-3614 and by the MARCO GSRC grant 98-DT-660.","status":"public","publication_status":"published"},{"citation":{"mla":"Shigemoto, Ryuichi, and Noboru Mizuno. “Chapter III Metabotropic Glutamate Receptors - Immunocytochemical and in Situ Hybridization Analyses.” Glutamate, vol. 18, Elsevier, 2000, pp. 63–98, doi:10.1016/S0924-8196(00)80044-5.","chicago":"Shigemoto, Ryuichi, and Noboru Mizuno. “Chapter III Metabotropic Glutamate Receptors - Immunocytochemical and in Situ Hybridization Analyses.” In Glutamate, 18:63–98. Elsevier, 2000. https://doi.org/10.1016/S0924-8196(00)80044-5.","short":"R. Shigemoto, N. Mizuno, in:, Glutamate, Elsevier, 2000, pp. 63–98.","ama":"Shigemoto R, Mizuno N. Chapter III Metabotropic glutamate receptors - immunocytochemical and in situ hybridization analyses. In: Glutamate. Vol 18. Elsevier; 2000:63-98. doi:10.1016/S0924-8196(00)80044-5","ista":"Shigemoto R, Mizuno N. 2000.Chapter III Metabotropic glutamate receptors - immunocytochemical and in situ hybridization analyses. In: Glutamate. Handbook of Chemical Neuroanatomy, vol. 18, 63–98.","ieee":"R. Shigemoto and N. Mizuno, “Chapter III Metabotropic glutamate receptors - immunocytochemical and in situ hybridization analyses,” in Glutamate, vol. 18, Elsevier, 2000, pp. 63–98.","apa":"Shigemoto, R., & Mizuno, N. (2000). Chapter III Metabotropic glutamate receptors - immunocytochemical and in situ hybridization analyses. In Glutamate (Vol. 18, pp. 63–98). Elsevier. https://doi.org/10.1016/S0924-8196(00)80044-5"},"day":"01","month":"01","publist_id":"4407","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","extern":"1","date_published":"2000-01-01T00:00:00Z","date_created":"2018-12-11T11:58:00Z","oa_version":"None","publisher":"Elsevier","intvolume":" 18","volume":18,"article_processing_charge":"No","quality_controlled":"1","type":"book_chapter","language":[{"iso":"eng"}],"title":"Chapter III Metabotropic glutamate receptors - immunocytochemical and in situ hybridization analyses","author":[{"first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444"},{"full_name":"Mizuno, Noboru","last_name":"Mizuno","first_name":"Noboru"}],"_id":"2494","abstract":[{"text":"This chapter focuses on metabotropic glutamate receptors (mGluRs). These receptors are linked to several intracellular signal transduction mechanisms via G-protein and are implicated in diverse functions of the mammalian central nervous system (CNS). These functions include mediation of slow excitatory and inhibitory responses; regulation of calcium channels, potassium channels, and non-selective cation channels; inhibition and facilitation of transmitter release; induction of long-term potentiation and long-term depression; and regulation of neuronal development. Functional diversity of the metabotropic glutamate receptor is reflected in molecular diversity of receptor subtypes. The sites of action of mGluRs are widely found throughout different membrane compartments of neuronal and glial cells. The chapter reviews the differential subcellular localization of metabotropic glutamate receptors in relation to transmitter release sites. Patterns of subcellular localization of mGluRs are different among three subgroups: group I and III mGluRs are mainly localized to somatodendritic and axonal domains of neurons, respectively, while group II mGluRs are extensively localized to both domains as well as to glial cell processes.","lang":"eng"}],"alternative_title":["Handbook of Chemical Neuroanatomy"],"year":"2000","doi":"10.1016/S0924-8196(00)80044-5","publication":"Glutamate","publication_identifier":{"eissn":["0924-8196"]},"date_updated":"2023-05-03T12:27:40Z","publication_status":"published","status":"public","page":"63 - 98"},{"external_id":{"pmid":["10620645"]},"date_published":"2000-01-06T00:00:00Z","extern":"1","date_created":"2018-12-11T11:58:35Z","scopus_import":"1","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publist_id":"4300","type":"journal_article","language":[{"iso":"eng"}],"quality_controlled":"1","publisher":"Massachussetts Medical Society","main_file_link":[{"open_access":"1","url":"https://www.nejm.org/doi/full/10.1056/nejm200001063420104"}],"intvolume":" 342","year":"2000","oa":1,"page":"21 - 27","article_type":"original","publication":"New England Journal of Medicine","date_updated":"2023-05-03T11:14:19Z","oa_version":"None","citation":{"mla":"Sillevis Smitt, Peter, et al. “Paraneoplastic Cerebellar Ataxia Due to Autoantibodies against a Glutamate Receptor.” New England Journal of Medicine, vol. 342, no. 1, Massachussetts Medical Society, 2000, pp. 21–27, doi:10.1056/NEJM200001063420104.","chicago":"Sillevis Smitt, Peter, Ayae Kinoshita, Bertie De Leeuw, Wiebe Moll, Michiel Coesmans, Dick Jaarsma, Sonja Henzen Logmans, et al. “Paraneoplastic Cerebellar Ataxia Due to Autoantibodies against a Glutamate Receptor.” New England Journal of Medicine. Massachussetts Medical Society, 2000. https://doi.org/10.1056/NEJM200001063420104.","apa":"Sillevis Smitt, P., Kinoshita, A., De Leeuw, B., Moll, W., Coesmans, M., Jaarsma, D., … Shigemoto, R. (2000). Paraneoplastic cerebellar ataxia due to autoantibodies against a glutamate receptor. New England Journal of Medicine. Massachussetts Medical Society. https://doi.org/10.1056/NEJM200001063420104","ieee":"P. Sillevis Smitt et al., “Paraneoplastic cerebellar ataxia due to autoantibodies against a glutamate receptor,” New England Journal of Medicine, vol. 342, no. 1. Massachussetts Medical Society, pp. 21–27, 2000.","ama":"Sillevis Smitt P, Kinoshita A, De Leeuw B, et al. Paraneoplastic cerebellar ataxia due to autoantibodies against a glutamate receptor. New England Journal of Medicine. 2000;342(1):21-27. doi:10.1056/NEJM200001063420104","short":"P. Sillevis Smitt, A. Kinoshita, B. De Leeuw, W. Moll, M. Coesmans, D. Jaarsma, S. Henzen Logmans, C. Vecht, C. De Zeeuw, N. Sekiyama, S. Nakanishi, R. Shigemoto, New England Journal of Medicine 342 (2000) 21–27.","ista":"Sillevis Smitt P, Kinoshita A, De Leeuw B, Moll W, Coesmans M, Jaarsma D, Henzen Logmans S, Vecht C, De Zeeuw C, Sekiyama N, Nakanishi S, Shigemoto R. 2000. Paraneoplastic cerebellar ataxia due to autoantibodies against a glutamate receptor. New England Journal of Medicine. 342(1), 21–27."},"day":"06","pmid":1,"month":"01","volume":342,"article_processing_charge":"No","abstract":[{"lang":"eng","text":"There are many types of cerebellar ataxia, including ataxia due to congenital or metabolic disorders and a paraneoplastic form in patients with gynecologic cancer, breast cancer, lung cancer, or Hodgkin's disease.1 This paraneoplastic syndrome is the only type of cerebellar ataxia associated with autoantibodies against neuronal antigens. Often, the neuronal antigens are aberrantly expressed by the tumor cells.2-4 The antineuronal autoantibodies are believed to cause cerebellar ataxia, but this is unproved.5,6 In Hodgkin's disease, the lymphoma precedes the ataxia by months to years in 80 percent of patients, and ataxia often occurs during a prolonged complete remission.4 Among patients with this type of ataxia, 30 percent have anti–Purkinje-cell antibodies, some of which have the features of the neuronal antibody anti-Tr.4,7\r\n\r\nWe identified a new autoantibody in two patients with severe cerebellar ataxia that developed while they were in remission from Hodgkin's disease. The antibody reacts specifically with the metabotropic glutamate receptor mGluR1 in mouse brain. Metabotropic glutamate receptors belong to a large family of cell-surface receptors that transmit signals into the cell by coupling to guanine nucleotide-binding proteins (G proteins) in the cytoplasm. Purified IgG from the serum of both patients blocked the glutamate-stimulated formation of inositol phosphates in Chinese-hamster-ovary (CHO) cells that expressed mGluR1α, and the injection of IgG from serum or cerebrospinal fluid into the cerebellar subarachnoid space of mice caused severe, reversible ataxia. These results indicate that antineuronal autoantibodies can cause disease of the central nervous system by blocking neuronal receptors."}],"issue":"1","doi":"10.1056/NEJM200001063420104","title":"Paraneoplastic cerebellar ataxia due to autoantibodies against a glutamate receptor","author":[{"full_name":"Sillevis Smitt, Peter","last_name":"Sillevis Smitt","first_name":"Peter"},{"last_name":"Kinoshita","full_name":"Kinoshita, Ayae","first_name":"Ayae"},{"full_name":"De Leeuw, Bertie","last_name":"De Leeuw","first_name":"Bertie"},{"full_name":"Moll, Wiebe","last_name":"Moll","first_name":"Wiebe"},{"full_name":"Coesmans, Michiel","last_name":"Coesmans","first_name":"Michiel"},{"first_name":"Dick","full_name":"Jaarsma, Dick","last_name":"Jaarsma"},{"full_name":"Henzen Logmans, Sonja","last_name":"Henzen Logmans","first_name":"Sonja"},{"first_name":"Charles","full_name":"Vecht, Charles","last_name":"Vecht"},{"first_name":"Chris","full_name":"De Zeeuw, Chris","last_name":"De Zeeuw"},{"full_name":"Sekiyama, Naotaka","last_name":"Sekiyama","first_name":"Naotaka"},{"full_name":"Nakanishi, Shigetada","last_name":"Nakanishi","first_name":"Shigetada"},{"full_name":"Shigemoto, Ryuichi","last_name":"Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","orcid":"0000-0001-8761-9444"}],"_id":"2598","publication_status":"published","status":"public","acknowledgement":"Supported in part by the Ministry of Education, Science, and Culture of Japan (Dr. Nakanishi and Dr. Shigemoto); CREST of Japan Science and Technology Corporation (Dr. Shigemoto); the Life Sciences Foundation (Dr. De Zeeuw); NWO (Dr. De Zeeuw and Dr. De Leeuw); and the Human Frontier Science Program (Dr. De Zeeuw and Dr. Shigemoto).\r\nDrs. Sillevis Smitt and Kinoshita contributed equally to the article. We are indebted to A. Aiba for providing mGluR1-deficient mice; to T. Maruyama for providing human mGluR1-expressing CHO cells; to H. Jingami for helpful discussion; to A. Uesugi for photographic assistance; to M. van den Bent and C. Gaillard for clinical information on the patients; and to J. van der Burg, S.K.E. Koekkoek, K.J. Reus, and C. Vermeer for technical assistance.","publication_identifier":{"issn":["0028-4793"]}},{"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publist_id":"4299","scopus_import":"1","date_created":"2018-12-11T11:58:36Z","extern":"1","external_id":{"pmid":["10701441"]},"date_published":"2000-03-06T00:00:00Z","intvolume":" 418","publisher":"Wiley-Blackwell","type":"journal_article","language":[{"iso":"eng"}],"quality_controlled":"1","year":"2000","date_updated":"2023-05-03T10:56:44Z","publication":"Journal of Comparative Neurology","article_type":"original","page":"156 - 163","pmid":1,"month":"03","day":"06","citation":{"ieee":"J. Li, D. Wang, T. Kaneko, R. Shigemoto, S. Nomura, and N. Mizuno, “Relationship between neurokinin-1 receptor and substance P in the striatum: Light and electron microscopic immunohistochemical study in the rat,” Journal of Comparative Neurology, vol. 418, no. 2. Wiley-Blackwell, pp. 156–163, 2000.","apa":"Li, J., Wang, D., Kaneko, T., Shigemoto, R., Nomura, S., & Mizuno, N. (2000). Relationship between neurokinin-1 receptor and substance P in the striatum: Light and electron microscopic immunohistochemical study in the rat. Journal of Comparative Neurology. Wiley-Blackwell. https://doi.org/10.1002/(SICI)1096-9861(20000306)418:2&lt;156::AID-CNE3&gt;3.0.CO;2-Z","short":"J. Li, D. Wang, T. Kaneko, R. Shigemoto, S. Nomura, N. Mizuno, Journal of Comparative Neurology 418 (2000) 156–163.","ama":"Li J, Wang D, Kaneko T, Shigemoto R, Nomura S, Mizuno N. Relationship between neurokinin-1 receptor and substance P in the striatum: Light and electron microscopic immunohistochemical study in the rat. Journal of Comparative Neurology. 2000;418(2):156-163. doi:10.1002/(SICI)1096-9861(20000306)418:2&lt;156::AID-CNE3&gt;3.0.CO;2-Z","ista":"Li J, Wang D, Kaneko T, Shigemoto R, Nomura S, Mizuno N. 2000. Relationship between neurokinin-1 receptor and substance P in the striatum: Light and electron microscopic immunohistochemical study in the rat. Journal of Comparative Neurology. 418(2), 156–163.","mla":"Li, Jin, et al. “Relationship between Neurokinin-1 Receptor and Substance P in the Striatum: Light and Electron Microscopic Immunohistochemical Study in the Rat.” Journal of Comparative Neurology, vol. 418, no. 2, Wiley-Blackwell, 2000, pp. 156–63, doi:10.1002/(SICI)1096-9861(20000306)418:2&lt;156::AID-CNE3&gt;3.0.CO;2-Z.","chicago":"Li, Jin, Dan Wang, Takeshi Kaneko, Ryuichi Shigemoto, Sakashi Nomura, and Noboru Mizuno. “Relationship between Neurokinin-1 Receptor and Substance P in the Striatum: Light and Electron Microscopic Immunohistochemical Study in the Rat.” Journal of Comparative Neurology. Wiley-Blackwell, 2000. https://doi.org/10.1002/(SICI)1096-9861(20000306)418:2&lt;156::AID-CNE3&gt;3.0.CO;2-Z."},"oa_version":"None","volume":418,"article_processing_charge":"No","_id":"2599","author":[{"first_name":"Jin","last_name":"Li","full_name":"Li, Jin"},{"last_name":"Wang","full_name":"Wang, Dan","first_name":"Dan"},{"first_name":"Takeshi","full_name":"Kaneko, Takeshi","last_name":"Kaneko"},{"orcid":"0000-0001-8761-9444","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","full_name":"Shigemoto, Ryuichi"},{"first_name":"Sakashi","full_name":"Nomura, Sakashi","last_name":"Nomura"},{"full_name":"Mizuno, Noboru","last_name":"Mizuno","first_name":"Noboru"}],"title":"Relationship between neurokinin-1 receptor and substance P in the striatum: Light and electron microscopic immunohistochemical study in the rat","doi":"10.1002/(SICI)1096-9861(20000306)418:2<156::AID-CNE3>3.0.CO;2-Z","issue":"2","abstract":[{"lang":"eng","text":"The synaptic relationship between substance P (SP) and its receptor, i.e., neurokinin-1 receptor (NK1R), was examined in the striatum of the rat by confocal laser-scanning microscopy and electron microscopy. For confocal laser-scanning microscopy, triple-immunofluorescence histochemistry was performed to label NK1R, SP, and vesicular acetylcholine transporter (a specific marker for cholinergic neurons). In electron microscopic double- immunolabeling study, immunoreactivity for NK1R was detected with the silver- intensified gold method, while immunoreactivity for SP was detected with peroxidase immunohistochemistry. Simultaneous immunolabeling of NK1R and SP revealed significant mismatch at the synaptic level: although some SP- immunopositive axon terminals were in synaptic contact with NK1R- immunopositive sites of plasma membrane, NK1R-immunoreactivity was observed at both synaptic and non-synaptic sites of plasma membrane. Thus, SP released from the sites remote from NK1Rs might diffuse in the extracellular fluid to act, as a paracrine neurotransmitter, on NK1Rs distant from its releasing site. SP neurotransmission in the striatum might occur not only synaptically but also extrasynaptically. The SP-NK1R system might constitute an association system within the striatum."}],"publication_identifier":{"issn":["0021-9967"]},"acknowledgement":"The authors are grateful for the photographic help of Ms. Yue-Ping Yuan, Mr. Akira Uesugi, Ms. Keiko Oka-moto, Mr. Nobuyuki Kobayashi, and Mr. Hideki Itabashi. The authors also express their gratitudes for the support of Dr. Kajitaro Morita in Morita Clinic of Internal Medicine and Pediatrics, Kadoma, Osaka, Japan","status":"public","publication_status":"published"},{"year":"2000","page":"327 - 334","article_type":"original","publication":"Neuroscience Research","date_updated":"2023-05-03T10:47:06Z","date_published":"2000-04-01T00:00:00Z","extern":"1","external_id":{"pmid":["10771111"]},"date_created":"2018-12-11T11:58:36Z","scopus_import":"1","publist_id":"4298","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","type":"journal_article","quality_controlled":"1","language":[{"iso":"eng"}],"publisher":"Elsevier","intvolume":" 36","abstract":[{"lang":"eng","text":"The synaptic relationship between substance P (SP) and its receptor, i.e. neurokinin-1 receptor (NK1R), was examined in the superficial laminae of the caudal subnucleus of the spinal trigeminal nucleus (medullary dorsal horn; MDH) of the rat. For confocal laser-scanning microscopy, double-immunofluorescence histochemistry for NK1 and SP was performed. In electron microscopic double-immunolabeling study, immunoreactivity for NK1R was detected with the silver-intensified gold method, while immunoreactivity for SP was detected with peroxidase immunohistochemistry. SP-immunoreactive axon terminals were observed to be in synaptic (mostly asymmetric) contact with NK1R-immunoreactive neuronal profiles in lamina I and lamina IIo. Although some SP-immunoreactive axon terminals were in synaptic contact with NK1R-immunoreactive sites of plasma membranes, NK1R-immunoreactivity was observed at both synaptic and non-synaptic sites of plasma membrane. Thus, SP released from axon terminals might not only act on NK1Rs facing the SP-containing axon terminals, but also diffuse in the extracellular fluid for distances larger than the synaptic cleft to act on NK1Rs at some distances from the synaptic sites. "}],"issue":"4","doi":"10.1016/S0168-0102(00)00095-X","title":"The relationship between neurokinin-1 receptor and substance P in the medullary dorsal horn: A light and electron microscopic immunohistochemical study in the rat","author":[{"last_name":"Li","full_name":"Li, Jin","first_name":"Jin"},{"first_name":"Dan","last_name":"Wang","full_name":"Wang, Dan"},{"full_name":"Kaneko, Takeshi","last_name":"Kaneko","first_name":"Takeshi"},{"orcid":"0000-0001-8761-9444","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","full_name":"Shigemoto, Ryuichi"},{"first_name":"Sakashi","full_name":"Nomura, Sakashi","last_name":"Nomura"},{"first_name":"Noboru","full_name":"Mizuno, Noboru","last_name":"Mizuno"}],"_id":"2600","status":"public","publication_status":"published","publication_identifier":{"issn":["0168-0102"]},"oa_version":"None","citation":{"ieee":"J. Li, D. Wang, T. Kaneko, R. Shigemoto, S. Nomura, and N. Mizuno, “The relationship between neurokinin-1 receptor and substance P in the medullary dorsal horn: A light and electron microscopic immunohistochemical study in the rat,” Neuroscience Research, vol. 36, no. 4. Elsevier, pp. 327–334, 2000.","apa":"Li, J., Wang, D., Kaneko, T., Shigemoto, R., Nomura, S., & Mizuno, N. (2000). The relationship between neurokinin-1 receptor and substance P in the medullary dorsal horn: A light and electron microscopic immunohistochemical study in the rat. Neuroscience Research. Elsevier. https://doi.org/10.1016/S0168-0102(00)00095-X","ama":"Li J, Wang D, Kaneko T, Shigemoto R, Nomura S, Mizuno N. The relationship between neurokinin-1 receptor and substance P in the medullary dorsal horn: A light and electron microscopic immunohistochemical study in the rat. Neuroscience Research. 2000;36(4):327-334. doi:10.1016/S0168-0102(00)00095-X","short":"J. Li, D. Wang, T. Kaneko, R. Shigemoto, S. Nomura, N. Mizuno, Neuroscience Research 36 (2000) 327–334.","ista":"Li J, Wang D, Kaneko T, Shigemoto R, Nomura S, Mizuno N. 2000. The relationship between neurokinin-1 receptor and substance P in the medullary dorsal horn: A light and electron microscopic immunohistochemical study in the rat. Neuroscience Research. 36(4), 327–334.","chicago":"Li, Jin, Dan Wang, Takeshi Kaneko, Ryuichi Shigemoto, Sakashi Nomura, and Noboru Mizuno. “The Relationship between Neurokinin-1 Receptor and Substance P in the Medullary Dorsal Horn: A Light and Electron Microscopic Immunohistochemical Study in the Rat.” Neuroscience Research. Elsevier, 2000. https://doi.org/10.1016/S0168-0102(00)00095-X.","mla":"Li, Jin, et al. “The Relationship between Neurokinin-1 Receptor and Substance P in the Medullary Dorsal Horn: A Light and Electron Microscopic Immunohistochemical Study in the Rat.” Neuroscience Research, vol. 36, no. 4, Elsevier, 2000, pp. 327–34, doi:10.1016/S0168-0102(00)00095-X."},"day":"01","pmid":1,"month":"04","article_processing_charge":"No","volume":36},{"publist_id":"4297","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","extern":"1","external_id":{"pmid":["10846166 "]},"date_published":"2000-06-09T00:00:00Z","date_created":"2018-12-11T11:58:36Z","scopus_import":"1","publisher":"American Association for the Advancement of Science","intvolume":" 288","type":"journal_article","language":[{"iso":"eng"}],"quality_controlled":"1","year":"2000","publication":"Science","date_updated":"2023-05-03T09:53:38Z","page":"1832 - 1835","article_type":"original","citation":{"mla":"Ichise, Taeko, et al. “MGluR1 in Cerebellar Purkinje Cells Essential for Long-Term Depression, Synapse Elimination, and Motor Coordination.” Science, vol. 288, no. 5472, American Association for the Advancement of Science, 2000, pp. 1832–35, doi:10.1126/science.288.5472.1832.","chicago":"Ichise, Taeko, Masanobu Kano, Kouichi Hashimoto, Dai Yanagihara, Kazuki Nakao, Ryuichi Shigemoto, Motoya Katsuki, and Atsu Aiba. “MGluR1 in Cerebellar Purkinje Cells Essential for Long-Term Depression, Synapse Elimination, and Motor Coordination.” Science. American Association for the Advancement of Science, 2000. https://doi.org/10.1126/science.288.5472.1832.","ista":"Ichise T, Kano M, Hashimoto K, Yanagihara D, Nakao K, Shigemoto R, Katsuki M, Aiba A. 2000. mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination. Science. 288(5472), 1832–1835.","ama":"Ichise T, Kano M, Hashimoto K, et al. mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination. Science. 2000;288(5472):1832-1835. doi:10.1126/science.288.5472.1832","short":"T. Ichise, M. Kano, K. Hashimoto, D. Yanagihara, K. Nakao, R. Shigemoto, M. Katsuki, A. Aiba, Science 288 (2000) 1832–1835.","apa":"Ichise, T., Kano, M., Hashimoto, K., Yanagihara, D., Nakao, K., Shigemoto, R., … Aiba, A. (2000). mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination. Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.288.5472.1832","ieee":"T. Ichise et al., “mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination,” Science, vol. 288, no. 5472. American Association for the Advancement of Science, pp. 1832–1835, 2000."},"day":"09","pmid":1,"month":"06","oa_version":"None","volume":288,"article_processing_charge":"No","title":"mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination","author":[{"last_name":"Ichise","full_name":"Ichise, Taeko","first_name":"Taeko"},{"last_name":"Kano","full_name":"Kano, Masanobu","first_name":"Masanobu"},{"full_name":"Hashimoto, Kouichi","last_name":"Hashimoto","first_name":"Kouichi"},{"first_name":"Dai","last_name":"Yanagihara","full_name":"Yanagihara, Dai"},{"first_name":"Kazuki","last_name":"Nakao","full_name":"Nakao, Kazuki"},{"orcid":"0000-0001-8761-9444","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","full_name":"Shigemoto, Ryuichi"},{"full_name":"Katsuki, Motoya","last_name":"Katsuki","first_name":"Motoya"},{"first_name":"Atsu","last_name":"Aiba","full_name":"Aiba, Atsu"}],"_id":"2601","abstract":[{"lang":"eng","text":"Targeted deletion of metabotropic glutamate receptor-subtype 1 (mGluR1) gene can cause defects in development and function in the cerebellum. We introduced the mGluR1α transgene into mGluR1-null mutant [mGluR1 (-/-)] mice with a Purkinje cell (PC)-specific promoter. mGluR1-rescue mice showed normal cerebellar long-term depression and regression of multiple climbing fiber innervation, events significantly impaired in mGluR1 (-/-) mice. The impaired motor coordination was rescued by this transgene, in a dose-dependent manner. We propose that mGluR1 in PCs is a key molecule for normal synapse formation, synaptic plasticity, and motor control in the cerebellum."}],"issue":"5472","doi":"10.1126/science.288.5472.1832","publication_identifier":{"issn":["0036-8075"]},"status":"public","publication_status":"published"},{"day":"01","citation":{"ama":"Perroy J, Prezèau L, De Waard M, Shigemoto R, Bockaërt J, Fagni L. Selective blockade of P/Q-type calcium channels by the metabotropic glutamate receptor type 7 involves a phospholipase C pathway in neurons. Journal of Neuroscience. 2000;20(21):7896-7904. doi:10.1523/JNEUROSCI.20-21-07896.2000","ista":"Perroy J, Prezèau L, De Waard M, Shigemoto R, Bockaërt J, Fagni L. 2000. Selective blockade of P/Q-type calcium channels by the metabotropic glutamate receptor type 7 involves a phospholipase C pathway in neurons. Journal of Neuroscience. 20(21), 7896–7904.","short":"J. Perroy, L. Prezèau, M. De Waard, R. Shigemoto, J. Bockaërt, L. Fagni, Journal of Neuroscience 20 (2000) 7896–7904.","apa":"Perroy, J., Prezèau, L., De Waard, M., Shigemoto, R., Bockaërt, J., & Fagni, L. (2000). Selective blockade of P/Q-type calcium channels by the metabotropic glutamate receptor type 7 involves a phospholipase C pathway in neurons. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.20-21-07896.2000","ieee":"J. Perroy, L. Prezèau, M. De Waard, R. Shigemoto, J. Bockaërt, and L. Fagni, “Selective blockade of P/Q-type calcium channels by the metabotropic glutamate receptor type 7 involves a phospholipase C pathway in neurons,” Journal of Neuroscience, vol. 20, no. 21. Society for Neuroscience, pp. 7896–7904, 2000.","mla":"Perroy, Julie, et al. “Selective Blockade of P/Q-Type Calcium Channels by the Metabotropic Glutamate Receptor Type 7 Involves a Phospholipase C Pathway in Neurons.” Journal of Neuroscience, vol. 20, no. 21, Society for Neuroscience, 2000, pp. 7896–904, doi:10.1523/JNEUROSCI.20-21-07896.2000.","chicago":"Perroy, Julie, Laurent Prezèau, Michel De Waard, Ryuichi Shigemoto, Joël Bockaërt, and Laurent Fagni. “Selective Blockade of P/Q-Type Calcium Channels by the Metabotropic Glutamate Receptor Type 7 Involves a Phospholipase C Pathway in Neurons.” Journal of Neuroscience. Society for Neuroscience, 2000. https://doi.org/10.1523/JNEUROSCI.20-21-07896.2000."},"pmid":1,"month":"11","oa_version":"Published Version","volume":20,"article_processing_charge":"No","author":[{"full_name":"Perroy, Julie","last_name":"Perroy","first_name":"Julie"},{"first_name":"Laurent","full_name":"Prezèau, Laurent","last_name":"Prezèau"},{"first_name":"Michel","full_name":"De Waard, Michel","last_name":"De Waard"},{"full_name":"Shigemoto, Ryuichi","last_name":"Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","orcid":"0000-0001-8761-9444"},{"first_name":"Joël","last_name":"Bockaërt","full_name":"Bockaërt, Joël"},{"first_name":"Laurent","full_name":"Fagni, Laurent","last_name":"Fagni"}],"title":"Selective blockade of P/Q-type calcium channels by the metabotropic glutamate receptor type 7 involves a phospholipase C pathway in neurons","_id":"2602","issue":"21","abstract":[{"text":"Although presynaptic localization of mGluR7 is well established, the mechanism by which the receptor may control Ca2+ channels in neurons is still unknown. We show here that cultured cerebellar granule cells express native metabotropic glutamate receptor type 7 (mGluR7) in neuritic processes, whereas transfected mGluR7 was also expressed in cell bodies. This allowed us to study the effect of the transfected receptor on somatic Ca2+ channels. In transfected neurons, mGuR7 selectively inhibited P/Q-type Ca2+ channels. The effect was mimicked by GTPγS and blocked by pertussis toxin (PTX) or a selective antibody raised against the G-protein αo subunit, indicating the involvement of a G(o)-like protein. The mGuR7 effect did not display the characteristics of a direct interaction between G-protein βγ subunits and the α1A Ca2+ channel subunit, but was abolished by quenching βγ subunits with specific intracellular peptides. Intracellular dialysis of G-protein βγ subunits did not mimic the action of mGluR7, suggesting that both G-protein βγ and αo subunits were required to mediate the effect. Inhibition of phospholipase C (PLC) blocked the inhibitory action of mGluR7, suggesting that a coincident activation of PLC by the G-protein βγ with αo subunits was required. The Ca2+ chelator BAPTA, as well as inhibition of either the inositol trisphosphate (IP3) receptor or protein kinase C (PKC) abolished the mGluR7 effect. Moreover, activation of native mGluR7 induced a PTX-dependent IP3 formation. These results indicated that IP3-mediated intracellular Ca2+ release was required for PKC-dependent inhibition of the Ca2+ channels. Possible control of synaptic transmission by the present mechanisms is discussed.","lang":"eng"}],"doi":"10.1523/JNEUROSCI.20-21-07896.2000","publication_identifier":{"issn":["0270-6474"]},"status":"public","publication_status":"published","acknowledgement":"This work was supported by Centre National de la Recherche Scientifique and grants from Association Française contre les Myopathies, Fondation pour la Recherche Médicale, Bayer (France), and Hoechst-Marrion-Roussel (FRHMR1/9702). We thank J. P. Pin and F. Ango for constructive discussion of this work. We also thank Dr. J. Saugstad (Atlanta, GA) for the rat mGluR7a cDNA, J. M. Sabatier (Marseille, France) for the synthesis of the 68 AA peptide, V. Homburger (Montpellier, France) for the anti-Gαo antibody, and B. Mouillac (Montpellier, France) for the anti-cMyc monoclonal antibody.","publist_id":"4296","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_published":"2000-11-01T00:00:00Z","external_id":{"pmid":["11050109"]},"extern":"1","scopus_import":"1","date_created":"2018-12-11T11:58:37Z","intvolume":" 20","main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772734/","open_access":"1"}],"publisher":"Society for Neuroscience","type":"journal_article","quality_controlled":"1","language":[{"iso":"eng"}],"oa":1,"year":"2000","publication":"Journal of Neuroscience","date_updated":"2023-05-03T09:48:17Z","article_type":"original","page":"7896 - 7904"},{"article_type":"original","page":"485 - 497","date_updated":"2023-05-03T09:41:55Z","publication":"Neuron","year":"2000","type":"journal_article","quality_controlled":"1","language":[{"iso":"eng"}],"intvolume":" 28","publisher":"Elsevier","scopus_import":"1","date_created":"2018-12-11T11:58:37Z","external_id":{"pmid":["11144358"]},"date_published":"2000-11-01T00:00:00Z","extern":"1","publist_id":"4295","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","acknowledgement":"We thank Drs. S. Nakanishi, K. Moriyoshi, V. I. Gelfand, and P. J. Conn for gifts of cDNAs and antibodies, A. S. Serpinskaya and H. Wu for excellent preparation of neuron cultures, and H. J. Chung for help in immunoblots. This work was supported by the Pew Chari-table Trust and National Institutes of Health grants NS33184 and NS39286 (A. M. C.), K02MH01152 and NIDA DA10309 (P. W.), and a fellowship from IPSEN Foundation (H. B.). ","publication_status":"published","status":"public","publication_identifier":{"issn":["0896-6273"]},"doi":"10.1016/S0896-6273(00)00127-6","issue":"2","abstract":[{"text":"Aggregation of neurotransmitter receptors at pre- and postsynaptic structures is crucial for efficient neuronal communication. In contrast to the wealth of information about postsynaptic specializations, little is known about the molecular organization of presynaptic membrane proteins. We show here that the metabotropic glutamate receptor mGluR7a, which localizes specifically to presynaptic active zones, interacts in vitro and in vivo with PICK1. Coexpression in heterologous systems induces coclustering dependent upon the extreme C terminus of mGluR7a and the PDZ domain of PICK1. mGluR7a and PICK1 localize to excitatory synapses in hippocampal neurons. Furthermore, whereas transfected mGluR7a clusters at presynaptic sites, mGluR7aΔ3 lacking the PICK1 binding site targets to axons but does not cluster. These results suggest that PICK1 is a component of the presynaptic machinery involved in mGlUR7a aggregation and in modulation of glutamate neurotransmission.","lang":"eng"}],"_id":"2603","author":[{"first_name":"Hélène","full_name":"Boudin, Hélène","last_name":"Boudin"},{"full_name":"Doan, Andrew","last_name":"Doan","first_name":"Andrew"},{"full_name":"Xia, Jun","last_name":"Xia","first_name":"Jun"},{"orcid":"0000-0001-8761-9444","last_name":"Shigemoto","full_name":"Shigemoto, Ryuichi","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Huganir","full_name":"Huganir, Richard","first_name":"Richard"},{"last_name":"Worley","full_name":"Worley, Paul","first_name":"Paul"},{"first_name":"Ann","full_name":"Craig, Ann","last_name":"Craig"}],"title":"Presynaptic clustering of mGluR7a requires the PICK1 PDZ domain binding site","volume":28,"article_processing_charge":"No","oa_version":"None","month":"11","pmid":1,"day":"01","citation":{"ama":"Boudin H, Doan A, Xia J, et al. Presynaptic clustering of mGluR7a requires the PICK1 PDZ domain binding site. Neuron. 2000;28(2):485-497. doi:10.1016/S0896-6273(00)00127-6","ista":"Boudin H, Doan A, Xia J, Shigemoto R, Huganir R, Worley P, Craig A. 2000. Presynaptic clustering of mGluR7a requires the PICK1 PDZ domain binding site. Neuron. 28(2), 485–497.","short":"H. Boudin, A. Doan, J. Xia, R. Shigemoto, R. Huganir, P. Worley, A. Craig, Neuron 28 (2000) 485–497.","apa":"Boudin, H., Doan, A., Xia, J., Shigemoto, R., Huganir, R., Worley, P., & Craig, A. (2000). Presynaptic clustering of mGluR7a requires the PICK1 PDZ domain binding site. Neuron. Elsevier. https://doi.org/10.1016/S0896-6273(00)00127-6","ieee":"H. Boudin et al., “Presynaptic clustering of mGluR7a requires the PICK1 PDZ domain binding site,” Neuron, vol. 28, no. 2. Elsevier, pp. 485–497, 2000.","mla":"Boudin, Hélène, et al. “Presynaptic Clustering of MGluR7a Requires the PICK1 PDZ Domain Binding Site.” Neuron, vol. 28, no. 2, Elsevier, 2000, pp. 485–97, doi:10.1016/S0896-6273(00)00127-6.","chicago":"Boudin, Hélène, Andrew Doan, Jun Xia, Ryuichi Shigemoto, Richard Huganir, Paul Worley, and Ann Craig. “Presynaptic Clustering of MGluR7a Requires the PICK1 PDZ Domain Binding Site.” Neuron. Elsevier, 2000. https://doi.org/10.1016/S0896-6273(00)00127-6."}},{"year":"2000","alternative_title":["AMS/IP Studies in Advanced Mathematics"],"page":"111 - 119","publication":"Differential Equations and Mathematical Physics","date_updated":"2023-05-03T09:37:03Z","external_id":{"arxiv":["math-ph/0001036"]},"date_published":"2000-01-01T00:00:00Z","extern":"1","date_created":"2018-12-11T11:59:12Z","publist_id":"4186","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","quality_controlled":"1","language":[{"iso":"eng"}],"type":"book_chapter","publisher":"American Mathematical Society","intvolume":" 16","abstract":[{"text":"In this paper we describe an intrinsically geometric way of producing magnetic fields on §3 and $\\R^3$ for which the corresponding Dirac operators have a non-trivial kernel. In many cases we are able to compute the dimension of the kernel. In particular we can give examples where the kernel has any given dimension. This generalizes the examples of Loss and Yau (Commun. Math. Phys. 104 (1986) 283-290).","lang":"eng"}],"doi":"10.1090/amsip/016","title":"The kernel of Dirac operators on S3 and R3","author":[{"orcid":"0000-0001-5366-9603","first_name":"László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","last_name":"Erdös","full_name":"Erdös, László"}],"_id":"2710","publication_status":"published","status":"public","acknowledgement":"L. Erdös was supported by the N.S.F. grant DMS-9970323. J. P. Solovej was supported in parts by the EU TMR-grant FMRX-CT 96-0001 by MaPhySto — Centre for Mathematical Physics and Stochastics, funded by a grant from The Danish National Research Foundation and by a grant from the Danish Natural Science Research Council.","publication_identifier":{"isbn":["9780821821572"]},"oa_version":"Preprint","citation":{"mla":"Erdös, László. “The Kernel of Dirac Operators on S3 and R3.” Differential Equations and Mathematical Physics, vol. 16, American Mathematical Society, 2000, pp. 111–19, doi:10.1090/amsip/016.","chicago":"Erdös, László. “The Kernel of Dirac Operators on S3 and R3.” In Differential Equations and Mathematical Physics, 16:111–19. American Mathematical Society, 2000. https://doi.org/10.1090/amsip/016.","ista":"Erdös L. 2000.The kernel of Dirac operators on S3 and R3. In: Differential Equations and Mathematical Physics. AMS/IP Studies in Advanced Mathematics, vol. 16, 111–119.","short":"L. Erdös, in:, Differential Equations and Mathematical Physics, American Mathematical Society, 2000, pp. 111–119.","ama":"Erdös L. The kernel of Dirac operators on S3 and R3. In: Differential Equations and Mathematical Physics. Vol 16. American Mathematical Society; 2000:111-119. doi:10.1090/amsip/016","apa":"Erdös, L. (2000). The kernel of Dirac operators on S3 and R3. In Differential Equations and Mathematical Physics (Vol. 16, pp. 111–119). American Mathematical Society. https://doi.org/10.1090/amsip/016","ieee":"L. Erdös, “The kernel of Dirac operators on S3 and R3,” in Differential Equations and Mathematical Physics, vol. 16, American Mathematical Society, 2000, pp. 111–119."},"day":"01","month":"01","volume":16,"article_processing_charge":"No","arxiv":1}]