[{"author":[{"orcid":"0000−0002−2985−7724","full_name":"Henzinger, Thomas A","first_name":"Thomas A","id":"40876CD8-F248-11E8-B48F-1D18A9856A87","last_name":"Henzinger"},{"full_name":"Qadeer, Shaz","first_name":"Shaz","last_name":"Qadeer"},{"last_name":"Rajamani","full_name":"Rajamani, Sriram","first_name":"Sriram"},{"last_name":"Tasiran","first_name":"Serdar","full_name":"Tasiran, Serdar"}],"year":"2002","publication_identifier":{"issn":["0164-0925"]},"date_published":"2002-01-01T00:00:00Z","status":"public","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","page":"51 - 64","article_processing_charge":"No","publication_status":"published","date_updated":"2023-06-05T07:59:47Z","_id":"4473","publisher":"ACM","publication":"ACM Transactions on Programming Languages and Systems (TOPLAS)","month":"01","issue":"1","article_type":"original","intvolume":"        24","extern":"1","abstract":[{"lang":"eng","text":"The simulation preorder on state transition systems is widely accepted as a useful notion of refinement, both in its own right and as an efficiently checkable sufficient condition for trace containment. For composite systems, due to the exponential explosion of the state space, there is a need for decomposing a simulation check of the form P ≤s Q, denoting &quot;P is simulated by Q,&quot; into simpler simulation checks on the components of P and Q. We present an assume-guarantee rule that enables such a decomposition. To the best of our knowledge, this is the first assume-guarantee rule that applies to a refinement relation different from trace containment. Our rule is circular, and its soundness proof requires induction on trace trees. The proof is constructive: given simulation relations that witness the simulation preorder between corresponding components of P and Q, we provide a procedure for constructing a witness relation for P ≤s Q. We also extend our assume-guarantee rule to account for fairness constraints on transition systems."}],"volume":24,"scopus_import":"1","title":"An assume-guarantee rule for checking simulation","date_created":"2018-12-11T12:09:02Z","language":[{"iso":"eng"}],"type":"journal_article","day":"01","publist_id":"256","citation":{"mla":"Henzinger, Thomas A., et al. “An Assume-Guarantee Rule for Checking Simulation.” <i>ACM Transactions on Programming Languages and Systems (TOPLAS)</i>, vol. 24, no. 1, ACM, 2002, pp. 51–64, doi:<a href=\"https://doi.org/10.1145/509705.509707\">10.1145/509705.509707</a>.","chicago":"Henzinger, Thomas A, Shaz Qadeer, Sriram Rajamani, and Serdar Tasiran. “An Assume-Guarantee Rule for Checking Simulation.” <i>ACM Transactions on Programming Languages and Systems (TOPLAS)</i>. ACM, 2002. <a href=\"https://doi.org/10.1145/509705.509707\">https://doi.org/10.1145/509705.509707</a>.","ista":"Henzinger TA, Qadeer S, Rajamani S, Tasiran S. 2002. An assume-guarantee rule for checking simulation. ACM Transactions on Programming Languages and Systems (TOPLAS). 24(1), 51–64.","apa":"Henzinger, T. A., Qadeer, S., Rajamani, S., &#38; Tasiran, S. (2002). An assume-guarantee rule for checking simulation. <i>ACM Transactions on Programming Languages and Systems (TOPLAS)</i>. ACM. <a href=\"https://doi.org/10.1145/509705.509707\">https://doi.org/10.1145/509705.509707</a>","ama":"Henzinger TA, Qadeer S, Rajamani S, Tasiran S. An assume-guarantee rule for checking simulation. <i>ACM Transactions on Programming Languages and Systems (TOPLAS)</i>. 2002;24(1):51-64. doi:<a href=\"https://doi.org/10.1145/509705.509707\">10.1145/509705.509707</a>","ieee":"T. A. Henzinger, S. Qadeer, S. Rajamani, and S. Tasiran, “An assume-guarantee rule for checking simulation,” <i>ACM Transactions on Programming Languages and Systems (TOPLAS)</i>, vol. 24, no. 1. ACM, pp. 51–64, 2002.","short":"T.A. Henzinger, S. Qadeer, S. Rajamani, S. Tasiran, ACM Transactions on Programming Languages and Systems (TOPLAS) 24 (2002) 51–64."},"doi":"10.1145/509705.509707","quality_controlled":"1","oa_version":"None"},{"main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/S0890540101930858?via%3Dihub","open_access":"1"}],"citation":{"apa":"Henzinger, T. A., Kupferman, O., &#38; Rajamani, S. (2002). Fair simulation. <i>Information and Computation</i>. Elsevier. <a href=\"https://doi.org/10.1006/inco.2001.3085\">https://doi.org/10.1006/inco.2001.3085</a>","ista":"Henzinger TA, Kupferman O, Rajamani S. 2002. Fair simulation. Information and Computation. 173(1), 64–81.","chicago":"Henzinger, Thomas A, Orna Kupferman, and Sriram Rajamani. “Fair Simulation.” <i>Information and Computation</i>. Elsevier, 2002. <a href=\"https://doi.org/10.1006/inco.2001.3085\">https://doi.org/10.1006/inco.2001.3085</a>.","ama":"Henzinger TA, Kupferman O, Rajamani S. Fair simulation. <i>Information and Computation</i>. 2002;173(1):64-81. doi:<a href=\"https://doi.org/10.1006/inco.2001.3085\">10.1006/inco.2001.3085</a>","short":"T.A. Henzinger, O. Kupferman, S. Rajamani, Information and Computation 173 (2002) 64–81.","ieee":"T. A. Henzinger, O. Kupferman, and S. Rajamani, “Fair simulation,” <i>Information and Computation</i>, vol. 173, no. 1. Elsevier, pp. 64–81, 2002.","mla":"Henzinger, Thomas A., et al. “Fair Simulation.” <i>Information and Computation</i>, vol. 173, no. 1, Elsevier, 2002, pp. 64–81, doi:<a href=\"https://doi.org/10.1006/inco.2001.3085\">10.1006/inco.2001.3085</a>."},"day":"25","type":"journal_article","publist_id":"255","quality_controlled":"1","doi":"10.1006/inco.2001.3085","oa_version":"Published Version","extern":"1","issue":"1","article_type":"original","intvolume":"       173","abstract":[{"text":"The simulation preorder for labeled transition systems is defined locally, and operationally, as a game that relates states with their immediate successor states. Simulation enjoys many appealing properties. First, simulation has a denotational characterization: system S simulates system I iff every computation tree embedded in the unrolling of I can be embedded also in the unrolling of S. Second, simulation has a logical characterization: S simulates I iff every universal branching-time formula satisfied by S is satisfied also by I. It follows that simulation is a suitable notion of implementation, and it is the coarsest abstraction of a system that preserves universal branching-time properties. Third, based on its local definition, simulation between finite-state systems can be checked in polynomial time. Finally, simulation implies trace containment, which cannot be defined locally and requires polynomial space for verification. Hence simulation is widely used both in manual and in automatic verification. Liveness assumptions about transition systems are typically modeled using fairness constraints. Existing notions of simulation for fair transition systems, however, are not local, and as a result, many appealing properties of the simulation preorder are lost. We propose a new view of fair simulation by extending the local definition of simulation to account for fairness: system View the MathML sourcefairly simulates system View the MathML source iff in the simulation game, there is a strategy that matches with each fair computation of View the MathML source a fair computation of View the MathML source. Our definition enjoys a denotational characterization and has a logical characterization: View the MathML source fairly simulates View the MathML source iff every fair computation tree (whose infinite paths are fair) embedded in the unrolling of View the MathML source can be embedded also in the unrolling of View the MathML source or, equivalently, iff every Fair-∀AFMC formula satisfied by View the MathML source is satisfied also by View the MathML source (∀AFMC is the universal fragment of the alternation-free μ-calculus). The locality of the definition leads us to a polynomial-time algorithm for checking fair simulation for finite-state systems with weak and strong fairness constraints. Finally, fair simulation implies fair trace containment and is therefore useful as an efficiently computable local criterion for proving linear-time abstraction hierarchies of fair systems.","lang":"eng"}],"volume":173,"scopus_import":"1","title":"Fair simulation","date_created":"2018-12-11T12:09:02Z","language":[{"iso":"eng"}],"publisher":"Elsevier","publication":"Information and Computation","month":"02","acknowledgement":"We thank Ramin Hojati, Doron Bustan, and the anonymous reviewers for their comments on this paper.","author":[{"first_name":"Thomas A","full_name":"Henzinger, Thomas A","orcid":"0000−0002−2985−7724","id":"40876CD8-F248-11E8-B48F-1D18A9856A87","last_name":"Henzinger"},{"last_name":"Kupferman","full_name":"Kupferman, Orna","first_name":"Orna"},{"full_name":"Rajamani, Sriram","first_name":"Sriram","last_name":"Rajamani"}],"oa":1,"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","page":"64 - 81","article_processing_charge":"No","year":"2002","publication_identifier":{"issn":["0890-5401"]},"date_published":"2002-02-25T00:00:00Z","status":"public","date_updated":"2023-06-05T07:53:27Z","publication_status":"published","_id":"4474"},{"publisher":"ACM","day":"01","type":"conference","publist_id":"254","citation":{"mla":"Henzinger, Thomas A., et al. “Lazy Abstraction.” <i>Proceedings of the 29th ACM SIGPLAN-SIGACT Symposium on Principles of Programming Languages</i>, ACM, 2002, pp. 58–70, doi:<a href=\"https://doi.org/10.1145/503272.503279\">10.1145/503272.503279</a>.","ama":"Henzinger TA, Jhala R, Majumdar R, Sutre G. Lazy abstraction. In: <i>Proceedings of the 29th ACM SIGPLAN-SIGACT Symposium on Principles of Programming Languages</i>. ACM; 2002:58-70. doi:<a href=\"https://doi.org/10.1145/503272.503279\">10.1145/503272.503279</a>","short":"T.A. Henzinger, R. Jhala, R. Majumdar, G. Sutre, in:, Proceedings of the 29th ACM SIGPLAN-SIGACT Symposium on Principles of Programming Languages, ACM, 2002, pp. 58–70.","ieee":"T. A. Henzinger, R. Jhala, R. Majumdar, and G. Sutre, “Lazy abstraction,” in <i>Proceedings of the 29th ACM SIGPLAN-SIGACT symposium on Principles of programming languages</i>, Portland, OR, USA, 2002, pp. 58–70.","chicago":"Henzinger, Thomas A, Ranjit Jhala, Ritankar Majumdar, and Grégoire Sutre. “Lazy Abstraction.” In <i>Proceedings of the 29th ACM SIGPLAN-SIGACT Symposium on Principles of Programming Languages</i>, 58–70. ACM, 2002. <a href=\"https://doi.org/10.1145/503272.503279\">https://doi.org/10.1145/503272.503279</a>.","apa":"Henzinger, T. A., Jhala, R., Majumdar, R., &#38; Sutre, G. (2002). Lazy abstraction. In <i>Proceedings of the 29th ACM SIGPLAN-SIGACT symposium on Principles of programming languages</i> (pp. 58–70). Portland, OR, USA: ACM. <a href=\"https://doi.org/10.1145/503272.503279\">https://doi.org/10.1145/503272.503279</a>","ista":"Henzinger TA, Jhala R, Majumdar R, Sutre G. 2002. Lazy abstraction. Proceedings of the 29th ACM SIGPLAN-SIGACT symposium on Principles of programming languages. POPL: Principles of Programming Languages, 58–70."},"quality_controlled":"1","doi":"10.1145/503272.503279","publication":"Proceedings of the 29th ACM SIGPLAN-SIGACT symposium on Principles of programming languages","oa_version":"None","month":"01","author":[{"full_name":"Henzinger, Thomas A","first_name":"Thomas A","orcid":"0000−0002−2985−7724","last_name":"Henzinger","id":"40876CD8-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Jhala","first_name":"Ranjit","full_name":"Jhala, Ranjit"},{"last_name":"Majumdar","full_name":"Majumdar, Ritankar","first_name":"Ritankar"},{"full_name":"Sutre, Grégoire","first_name":"Grégoire","last_name":"Sutre"}],"extern":"1","acknowledgement":"We thank Wes Weimer and Jeff Foster for many useful discussions. \r\n","abstract":[{"lang":"eng","text":"One approach to model checking software is based on the abstract-check-refine paradigm: build an abstract model, then check the desired property, and if the check fails, refine the model and start over. We introduce the concept of lazy abstraction to integrate and optimize the three phases of the abstract-check-refine loop. Lazy abstraction continuously builds and refines a single abstract model on demand, driven by the model checker, so that different parts of the model may exhibit different degrees of precision, namely just enough to verify the desired property. We present an algorithm for model checking safety properties using lazy abstraction and describe an implementation of the algorithm applied to C programs. We also provide sufficient conditions for the termination of the method."}],"publication_identifier":{"isbn":["9781581134506"]},"year":"2002","date_published":"2002-01-01T00:00:00Z","status":"public","page":"58 - 70","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","scopus_import":"1","title":"Lazy abstraction","publication_status":"published","date_updated":"2023-06-05T07:45:53Z","conference":{"start_date":"2002-01-16","end_date":"2002-01-18","location":"Portland, OR, USA","name":"POPL: Principles of Programming Languages"},"date_created":"2018-12-11T12:09:03Z","language":[{"iso":"eng"}],"_id":"4476"},{"date_created":"2018-12-11T11:58:37Z","language":[{"iso":"eng"}],"scopus_import":"1","title":"Light and electron microscopic study of the distribution of substance P-immunoreactive fibers and neurokinin-1 receptors in the skin of the rat lower lip","abstract":[{"lang":"eng","text":"Cutaneous antidromic vasodilatation and plasma extravasation, two phenomena that occur in neurogenic inflammation, are partially blocked by substance P (SP) receptor antagonists and are known to be mediated in part by mast cell-released substances, such as histamine, serotonin, and nitric oxide. In an attempt to provide a morphological substrate for the above phenomena, we applied light and electron microscopic immunocytochemistry to investigate the pattern of SP innervation of blood vessels and its relationship to mast cells in the skin of the rat lower lip. Furthermore, we examined the distribution of SP (neurokinin-1) receptors and their relationship to SP-immunoreactive (IR) fibers. Our results confirmed that SP-IR fibers are found in cutaneous nerves and that terminal branches are observed around blood vessels and penetrating the epidermis. SP-IR fibers also innervated hair follicles and sebaceous glands. At the ultrastructural level, SP-IR varicosities were observed adjacent to arterioles, capillaries, venules, and mast cells. The varicosities possessed both dense core vesicles and agranular synaptic vesicles. We quantified the distance between SP-IR varicosities and blood vessel endothelial cells. SP-IR terminals were located within 0.23-5.99 μm from the endothelial cell layer in 82.7% of arterioles, in 90.2% of capillaries, and in 86.9% of venules. Although there was a trend for SP-IR fibers to be located closer to the endothelium of venules, this difference was not significant. Neurokinin-1 receptor (NK-1r) immunoreactivity was most abundant in the upper dermis and was associated with the wall of blood vessels. NK-1r were located in equal amounts on the walls of arterioles, capillaries, and venules that were innervated by SP-IR fibers. The present results favor the concept of a participation of SP in cutaneous neurogenic vasodilatation and plasma extravasation both by an action on blood vessels after binding to the NK-1r and by causing the release of substances from mast cells after diffusion through the connective tissue."}],"volume":432,"article_type":"original","issue":"4","intvolume":"       432","extern":"1","oa_version":"None","quality_controlled":"1","doi":"10.1002/cne.1114","day":"16","type":"journal_article","publist_id":"4294","citation":{"ama":"Ruocco I, Cuello A, Shigemoto R, Ribeiro Da Silva A. Light and electron microscopic study of the distribution of substance P-immunoreactive fibers and neurokinin-1 receptors in the skin of the rat lower lip. <i>Journal of Comparative Neurology</i>. 2001;432(4):466-480. doi:<a href=\"https://doi.org/10.1002/cne.1114\">10.1002/cne.1114</a>","short":"I. Ruocco, A. Cuello, R. Shigemoto, A. Ribeiro Da Silva, Journal of Comparative Neurology 432 (2001) 466–480.","ieee":"I. Ruocco, A. Cuello, R. Shigemoto, and A. Ribeiro Da Silva, “Light and electron microscopic study of the distribution of substance P-immunoreactive fibers and neurokinin-1 receptors in the skin of the rat lower lip,” <i>Journal of Comparative Neurology</i>, vol. 432, no. 4. Wiley-Blackwell, pp. 466–480, 2001.","chicago":"Ruocco, Isabella, Augusto Cuello, Ryuichi Shigemoto, and Alfredo Ribeiro Da Silva. “Light and Electron Microscopic Study of the Distribution of Substance P-Immunoreactive Fibers and Neurokinin-1 Receptors in the Skin of the Rat Lower Lip.” <i>Journal of Comparative Neurology</i>. Wiley-Blackwell, 2001. <a href=\"https://doi.org/10.1002/cne.1114\">https://doi.org/10.1002/cne.1114</a>.","ista":"Ruocco I, Cuello A, Shigemoto R, Ribeiro Da Silva A. 2001. Light and electron microscopic study of the distribution of substance P-immunoreactive fibers and neurokinin-1 receptors in the skin of the rat lower lip. Journal of Comparative Neurology. 432(4), 466–480.","apa":"Ruocco, I., Cuello, A., Shigemoto, R., &#38; Ribeiro Da Silva, A. (2001). Light and electron microscopic study of the distribution of substance P-immunoreactive fibers and neurokinin-1 receptors in the skin of the rat lower lip. <i>Journal of Comparative Neurology</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1002/cne.1114\">https://doi.org/10.1002/cne.1114</a>","mla":"Ruocco, Isabella, et al. “Light and Electron Microscopic Study of the Distribution of Substance P-Immunoreactive Fibers and Neurokinin-1 Receptors in the Skin of the Rat Lower Lip.” <i>Journal of Comparative Neurology</i>, vol. 432, no. 4, Wiley-Blackwell, 2001, pp. 466–80, doi:<a href=\"https://doi.org/10.1002/cne.1114\">10.1002/cne.1114</a>."},"_id":"2604","publication_status":"published","date_updated":"2023-05-24T13:03:51Z","publication_identifier":{"issn":["0021-9967"]},"year":"2001","status":"public","date_published":"2001-04-16T00:00:00Z","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","page":"466 - 480","article_processing_charge":"No","external_id":{"pmid":["11268009"]},"author":[{"last_name":"Ruocco","full_name":"Ruocco, Isabella","first_name":"Isabella"},{"last_name":"Cuello","first_name":"Augusto","full_name":"Cuello, Augusto"},{"last_name":"Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Shigemoto, Ryuichi","first_name":"Ryuichi","orcid":"0000-0001-8761-9444"},{"full_name":"Ribeiro Da Silva, Alfredo","first_name":"Alfredo","last_name":"Ribeiro Da Silva"}],"acknowledgement":"This work was sponsored by grant MT-12170 from the Canadian Medical Research Council. The authors thank Marie Ballak for electron microscopy assistance, Alan Forster  for  photographic  expertise,  and  Sid  Parkinson  for editorial assistance.","month":"04","pmid":1,"publication":"Journal of Comparative Neurology","publisher":"Wiley-Blackwell"},{"date_updated":"2023-05-24T12:45:30Z","publication_status":"published","_id":"2605","external_id":{"pmid":["11377850"]},"author":[{"last_name":"Geurts","full_name":"Geurts, Frederik","first_name":"Frederik"},{"full_name":"Timmermans, Jean","first_name":"Jean","last_name":"Timmermans"},{"last_name":"Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Shigemoto, Ryuichi","first_name":"Ryuichi","orcid":"0000-0001-8761-9444"},{"last_name":"De Schutter","full_name":"De Schutter, Erik","first_name":"Erik"}],"article_processing_charge":"No","page":"499 - 512","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_published":"2001-05-10T00:00:00Z","status":"public","publication_identifier":{"issn":["0306-4522"]},"year":"2001","publication":"Neuroscience","pmid":1,"month":"05","publisher":"Elsevier","title":"Morphological and neurochemical differentiation of large granular layer interneurons in the adult rat cerebellum","scopus_import":"1","language":[{"iso":"eng"}],"date_created":"2018-12-11T11:58:38Z","extern":"1","intvolume":"       104","issue":"2","article_type":"original","volume":104,"abstract":[{"text":"The granular layer of the cerebellar cortex consists of densely packed neuronal cells, classified into granule cells and large interneurons. In this study, we provide a comparative survey of large granular layer interneurons in the adult rat cerebellum based on both morphological and neurochemical criteria. To this end, double immunofluorescence histochemistry was performed by combining antibodies against the cytoplasmic antigen Rat-303, calretinin, the metabotropic glutamate receptor mGluR2 and somatostatin. Based on Rat-303/calretinin double immunohistochemistry, three distinct populations of large granular layer interneurons could be discerned: cells immunopositive for Rat-303, calretinin or both. Rat-303 or calretinin single-labeled cells represented Golgi cells and unipolar brush cells, respectively. Rat-303/calretinin double-labeled cells located just underneath the Purkinje cell layer represented Lugaro cells. Morphometrical analysis distinguished two populations of Rat-303-positive Golgi cells according to their location: vermis versus hemisphere. Immunostaining for the metabotropic glutamate receptor mGluR2 combined with Rat-303 or calretinin revealed that the majority of Golgi cells (about 90%) appeared to be mGluR2 positive. Lugaro cells were mGluR2 negative. In addition, a limited population of large polymorphous interneurons in the depth of the granular layer with morphological features resembling Golgi cells also displayed Rat-303/calretinin immunoreactivity and were mGluR2 negative. Double immunohistochemistry for Rat-303 and somatostatin revealed three populations of labeled cells in the depth of the granular layer. Besides double-labeled Golgi cells, Rat-303 or somatostatin single-labeled cells were present. Based on mGluR2/somatostatin and calretinin/somatostatin double immunostainings, Rat-303 single-labeled cells were found to correspond to Rat-303/calretinin-positive, mGluR2-negative Golgi-like cells, while the identity of somatostatin single-labeled cells remained unclear. The data presented in this article elaborate previous reports on the morphological and neurochemical differentiation of large interneurons in the rat cerebellar granular layer. In addition, they indicate that the current classification of these cells into Golgi cells, Lugaro cells and unipolar brush cells does not describe the observed neurochemical heterogeneity.","lang":"eng"}],"quality_controlled":"1","doi":"10.1016/S0306-4522(01)00058-6","oa_version":"None","citation":{"ieee":"F. Geurts, J. Timmermans, R. Shigemoto, and E. De Schutter, “Morphological and neurochemical differentiation of large granular layer interneurons in the adult rat cerebellum,” <i>Neuroscience</i>, vol. 104, no. 2. Elsevier, pp. 499–512, 2001.","short":"F. Geurts, J. Timmermans, R. Shigemoto, E. De Schutter, Neuroscience 104 (2001) 499–512.","ama":"Geurts F, Timmermans J, Shigemoto R, De Schutter E. Morphological and neurochemical differentiation of large granular layer interneurons in the adult rat cerebellum. <i>Neuroscience</i>. 2001;104(2):499-512. doi:<a href=\"https://doi.org/10.1016/S0306-4522(01)00058-6\">10.1016/S0306-4522(01)00058-6</a>","chicago":"Geurts, Frederik, Jean Timmermans, Ryuichi Shigemoto, and Erik De Schutter. “Morphological and Neurochemical Differentiation of Large Granular Layer Interneurons in the Adult Rat Cerebellum.” <i>Neuroscience</i>. Elsevier, 2001. <a href=\"https://doi.org/10.1016/S0306-4522(01)00058-6\">https://doi.org/10.1016/S0306-4522(01)00058-6</a>.","ista":"Geurts F, Timmermans J, Shigemoto R, De Schutter E. 2001. Morphological and neurochemical differentiation of large granular layer interneurons in the adult rat cerebellum. Neuroscience. 104(2), 499–512.","apa":"Geurts, F., Timmermans, J., Shigemoto, R., &#38; De Schutter, E. (2001). Morphological and neurochemical differentiation of large granular layer interneurons in the adult rat cerebellum. <i>Neuroscience</i>. Elsevier. <a href=\"https://doi.org/10.1016/S0306-4522(01)00058-6\">https://doi.org/10.1016/S0306-4522(01)00058-6</a>","mla":"Geurts, Frederik, et al. “Morphological and Neurochemical Differentiation of Large Granular Layer Interneurons in the Adult Rat Cerebellum.” <i>Neuroscience</i>, vol. 104, no. 2, Elsevier, 2001, pp. 499–512, doi:<a href=\"https://doi.org/10.1016/S0306-4522(01)00058-6\">10.1016/S0306-4522(01)00058-6</a>."},"publist_id":"4292","day":"10","type":"journal_article"},{"extern":"1","issue":"6","article_type":"original","intvolume":"        13","abstract":[{"lang":"eng","text":"Glutamate receptors have been linked to the regulation of several developmental events in the CNS. By using cortical slices of early postnatal mice, we show that in layer I cells, glutamate produces intracellular calcium ([Ca2+]i) elevations mediated by ionotropic and metabotropic glutamate receptors (mGluRs). The contribution of mGluRs to these responses was demonstrated by application of tACPD, an agonist to groups I and II mGluRs, which evoked [Ca2+]i increases that could be reversibly blocked by MCPG, an antagonist to groups I and II mGluRs. In the absence of extracellular Ca2+, repetitive applications of tACPD or quisqualate, an agonist to group I mGluRs, elicited decreasing [Ca2+]i responses that were restored by refilling a thapsigargin-sensitive Ca2+ store. The use of specific group I mGluR agonists CHPG and DHPG indicated that the functional mGluR in layer I was of the mGluR1 subtype. Subtype specific antibodies confirmed the presence of mGlur1α, but not mGluR5, in Cajal-Retzius (Reelin-immunoreactive) neurons."}],"volume":13,"scopus_import":"1","title":"Cajal-Retzius cells in early postnatal mouse cortex selectively express functional metabotropic glutamate receptors","date_created":"2018-12-11T11:58:38Z","language":[{"iso":"eng"}],"citation":{"apa":"Martínez, G., López Bendito, G., Luján, R., Shigemoto, R., Fairén, A., &#38; Valdeolmillos, M. (2001). Cajal-Retzius cells in early postnatal mouse cortex selectively express functional metabotropic glutamate receptors. <i>European Journal of Neuroscience</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1046/j.0953-816X.2001.01494.x\">https://doi.org/10.1046/j.0953-816X.2001.01494.x</a>","chicago":"Martínez, Galán, Guillermina López Bendito, Rafael Luján, Ryuichi Shigemoto, Alfonso Fairén, and Miguel Valdeolmillos. “Cajal-Retzius Cells in Early Postnatal Mouse Cortex Selectively Express Functional Metabotropic Glutamate Receptors.” <i>European Journal of Neuroscience</i>. Wiley-Blackwell, 2001. <a href=\"https://doi.org/10.1046/j.0953-816X.2001.01494.x\">https://doi.org/10.1046/j.0953-816X.2001.01494.x</a>.","ista":"Martínez G, López Bendito G, Luján R, Shigemoto R, Fairén A, Valdeolmillos M. 2001. Cajal-Retzius cells in early postnatal mouse cortex selectively express functional metabotropic glutamate receptors. European Journal of Neuroscience. 13(6), 1147–1154.","short":"G. Martínez, G. López Bendito, R. Luján, R. Shigemoto, A. Fairén, M. Valdeolmillos, European Journal of Neuroscience 13 (2001) 1147–1154.","ama":"Martínez G, López Bendito G, Luján R, Shigemoto R, Fairén A, Valdeolmillos M. Cajal-Retzius cells in early postnatal mouse cortex selectively express functional metabotropic glutamate receptors. <i>European Journal of Neuroscience</i>. 2001;13(6):1147-1154. doi:<a href=\"https://doi.org/10.1046/j.0953-816X.2001.01494.x\">10.1046/j.0953-816X.2001.01494.x</a>","ieee":"G. Martínez, G. López Bendito, R. Luján, R. Shigemoto, A. Fairén, and M. Valdeolmillos, “Cajal-Retzius cells in early postnatal mouse cortex selectively express functional metabotropic glutamate receptors,” <i>European Journal of Neuroscience</i>, vol. 13, no. 6. Wiley-Blackwell, pp. 1147–1154, 2001.","mla":"Martínez, Galán, et al. “Cajal-Retzius Cells in Early Postnatal Mouse Cortex Selectively Express Functional Metabotropic Glutamate Receptors.” <i>European Journal of Neuroscience</i>, vol. 13, no. 6, Wiley-Blackwell, 2001, pp. 1147–54, doi:<a href=\"https://doi.org/10.1046/j.0953-816X.2001.01494.x\">10.1046/j.0953-816X.2001.01494.x</a>."},"day":"01","type":"journal_article","publist_id":"4293","quality_controlled":"1","doi":"10.1046/j.0953-816X.2001.01494.x","oa_version":"None","acknowledgement":"MV  and  AF  are  senior  coauthors  of  this  work,  which  was  supported  by Ministerio de Educacion y Cultura, grants SAF97/0195 and SAF 2000-0152-C02-02 to M.V; PB94-0219-CO2-01 and PB97-0582-CO2-01 to A.F., Accio Especial  de  R+D  AE98-18  from  Generalitat  Valenciana,  and  a  Fellowship from Bancaixa-C.S.I.C. to J.R.M.-G. We wish to thank Andre M. Goffinet for his  G10  antireelin  antibody  and  Roberto  Gallego,  Juan  M.  Luque  and  Felix Viana for their constructive criticisms on previous versions of the manuscript.","author":[{"full_name":"Martínez, Galán","first_name":"Galán","last_name":"Martínez"},{"last_name":"López Bendito","full_name":"López Bendito, Guillermina","first_name":"Guillermina"},{"last_name":"Luján","full_name":"Luján, Rafael","first_name":"Rafael"},{"last_name":"Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444","first_name":"Ryuichi","full_name":"Shigemoto, Ryuichi"},{"last_name":"Fairén","first_name":"Alfonso","full_name":"Fairén, Alfonso"},{"last_name":"Valdeolmillos","full_name":"Valdeolmillos, Miguel","first_name":"Miguel"}],"external_id":{"pmid":["11285012"]},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","page":"1147 - 1154","article_processing_charge":"No","publication_identifier":{"issn":["0953-816X"]},"year":"2001","date_published":"2001-03-01T00:00:00Z","status":"public","date_updated":"2023-05-24T12:53:46Z","publication_status":"published","_id":"2606","publisher":"Wiley-Blackwell","publication":"European Journal of Neuroscience","pmid":1,"month":"03"},{"publisher":"Academic Press","month":"06","pmid":1,"publication":"Molecular and Cellular Neuroscience","publication_identifier":{"issn":["1044-7431"]},"year":"2001","date_published":"2001-06-01T00:00:00Z","status":"public","page":"957 - 972","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","external_id":{"pmid":["11414786"]},"author":[{"last_name":"Mion","first_name":"Silvia","full_name":"Mion, Silvia"},{"full_name":"Corti, Corrado","first_name":"Corrado","last_name":"Corti"},{"full_name":"Neki, Akio","first_name":"Akio","last_name":"Neki"},{"last_name":"Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444","first_name":"Ryuichi","full_name":"Shigemoto, Ryuichi"},{"last_name":"Corsi","first_name":"Mauro","full_name":"Corsi, Mauro"},{"last_name":"Fumagalli","first_name":"Guido","full_name":"Fumagalli, Guido"},{"last_name":"Ferraguti","full_name":"Ferraguti, Francesco","first_name":"Francesco"}],"acknowledgement":"The authors thank: Dr. J. M. Rimland and M. T. Scupoli for their technical help with X. oocytes recordings and FAC sorting, respectively; Dr. Y. Dalezios for helping with the statistical analyses; and Dr. G. Varani for helping with the analyses of mRNA and genomic sequences. We are also grateful to Professor F. Benfenati, Dr. F. Conquet, Dr. Rafael Lujan, Dr. J. McIlhinney, Professor P. Somogyi, Dr. J. H. Xuereb, and Dr. M. Zoli for careful reading of the manuscript\r\nand helpful suggestions. R.S. is supported by the Laboratory of Cerebral Structure, National Institute for Physiological Sciences, Myodaiji, Okazaki 444-8585, CREST Japan Science and Technology Corporation, Japan.","_id":"2607","publication_status":"published","date_updated":"2023-05-24T09:34:13Z","type":"journal_article","day":"01","publist_id":"4291","citation":{"mla":"Mion, Silvia, et al. “Bidirectional Regulation of Neurite Elaboration by Alternatively Spliced Metabotropic Glutamate Receptor 5 (MGluR5) Isoforms.” <i>Molecular and Cellular Neuroscience</i>, vol. 17, no. 6, Academic Press, 2001, pp. 957–72, doi:<a href=\"https://doi.org/10.1006/mcne.2001.0993\">10.1006/mcne.2001.0993</a>.","ieee":"S. Mion <i>et al.</i>, “Bidirectional regulation of neurite elaboration by alternatively spliced metabotropic glutamate receptor 5 (mGluR5) isoforms,” <i>Molecular and Cellular Neuroscience</i>, vol. 17, no. 6. Academic Press, pp. 957–972, 2001.","ama":"Mion S, Corti C, Neki A, et al. Bidirectional regulation of neurite elaboration by alternatively spliced metabotropic glutamate receptor 5 (mGluR5) isoforms. <i>Molecular and Cellular Neuroscience</i>. 2001;17(6):957-972. doi:<a href=\"https://doi.org/10.1006/mcne.2001.0993\">10.1006/mcne.2001.0993</a>","short":"S. Mion, C. Corti, A. Neki, R. Shigemoto, M. Corsi, G. Fumagalli, F. Ferraguti, Molecular and Cellular Neuroscience 17 (2001) 957–972.","ista":"Mion S, Corti C, Neki A, Shigemoto R, Corsi M, Fumagalli G, Ferraguti F. 2001. Bidirectional regulation of neurite elaboration by alternatively spliced metabotropic glutamate receptor 5 (mGluR5) isoforms. Molecular and Cellular Neuroscience. 17(6), 957–972.","apa":"Mion, S., Corti, C., Neki, A., Shigemoto, R., Corsi, M., Fumagalli, G., &#38; Ferraguti, F. (2001). Bidirectional regulation of neurite elaboration by alternatively spliced metabotropic glutamate receptor 5 (mGluR5) isoforms. <i>Molecular and Cellular Neuroscience</i>. Academic Press. <a href=\"https://doi.org/10.1006/mcne.2001.0993\">https://doi.org/10.1006/mcne.2001.0993</a>","chicago":"Mion, Silvia, Corrado Corti, Akio Neki, Ryuichi Shigemoto, Mauro Corsi, Guido Fumagalli, and Francesco Ferraguti. “Bidirectional Regulation of Neurite Elaboration by Alternatively Spliced Metabotropic Glutamate Receptor 5 (MGluR5) Isoforms.” <i>Molecular and Cellular Neuroscience</i>. Academic Press, 2001. <a href=\"https://doi.org/10.1006/mcne.2001.0993\">https://doi.org/10.1006/mcne.2001.0993</a>."},"oa_version":"None","doi":"10.1006/mcne.2001.0993","quality_controlled":"1","abstract":[{"lang":"eng","text":"Alternative splicing in the mGluR5 gene generates two different receptor isoforms, of which expression is developmentally regulated. However, little is known about the functional significance of mGluR5 splice variants. We have examined the functional coupling, subcellular targeting, and effect on neuronal differentiation of epitope-tagged mGluR5 isoforms by expression in neuroblastoma NG108-15 cells. We found that both mGluR5 splice variants give rise to comparable [Ca2+]i transients and have similar pharmacological profile. Tagged receptors were shown by immunofluorescence to be inserted in the plasma membrane. In undifferentiated cells the subcellular localization of the two mGluR5 isoforms was partially segregated, whereas in differentiated cells the labeling largely redistributed to the newly formed neurites. Interestingly, we demonstrate that mGluR5 splice variants dramatically influence the formation and maturation of neurites; mGluR5a hinders the acquisition of mature neuronal traits and mGluR5b fosters the elaboration and extension of neurites. These effects are partly inhibited by MPEP."}],"volume":17,"article_type":"original","issue":"6","intvolume":"        17","extern":"1","date_created":"2018-12-11T11:58:38Z","language":[{"iso":"eng"}],"scopus_import":"1","title":"Bidirectional regulation of neurite elaboration by alternatively spliced metabotropic glutamate receptor 5 (mGluR5) isoforms"},{"status":"public","date_published":"2001-07-27T00:00:00Z","publication_identifier":{"issn":["0306-4522"]},"year":"2001","article_processing_charge":"No","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","page":"413 - 429","author":[{"last_name":"López Bendito","full_name":"López Bendito, Guillermina","first_name":"Guillermina"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","full_name":"Shigemoto, Ryuichi","first_name":"Ryuichi","orcid":"0000-0001-8761-9444"},{"full_name":"Luján, Rafael","first_name":"Rafael","last_name":"Luján"},{"full_name":"Juíz, José","first_name":"José","last_name":"Juíz"}],"external_id":{"pmid":["11672608 "]},"acknowledgement":"öWe thank Drs. Paul Bolam, Ole Paulsen, Je¡ McIlhinney, Alfonso Faire¨n and Francisco Ciruela for reviewing a previous version of this manuscript and Mrs Alexandra Salewski for the English revision of the manuscript. We also want to thank Dr. Peter Somogyi for offering the facilities of the MRC Anatomical Neuropharmacology Unit to carry out part of this study. This work was supported by a Grant from the European Community (QLG3-CT-1999-00192 to R.L.) and the Spanish Ministry of Education (DGES PM 97-0082 to J.M.J.).","_id":"2608","publication_status":"published","date_updated":"2023-05-24T09:31:48Z","publisher":"Elsevier","month":"07","pmid":1,"publication":"Neuroscience","volume":105,"abstract":[{"text":"The regulation of neurotransmitter receptors during synapse formation has been studied extensively at the neuromuscular junction, but little is known about the development of excitatory neurotransmitter receptors during synaptogenesis in central synapses. In this study we show qualitatively and quantitatively that a receptor undergoes changes in localisation on the surface of rat Purkinje cells during development in association with its excitatory synapses. The presence of mGluR1α at parallel and climbing fibre synapses on developing Purkinje cells was studied using high-resolution immunoelectron microscopy. Immunoreactivity for mGluR1α was detected from embryonic day 18 in Purkinje cells, and showed dramatic changes in its localisation with age. At early postnatal ages (P0 and P3), mGluR1α was found both in somata and stem dendrites but was not usually associated with synaptic contacts. At P7, mGluR1α became concentrated in somatic spines associated with climbing fibres and in the growing dendritic arborisation even before innervation by parallel fibres. During the second and third postnatal week, when spines and parallel fibre synapses were generated, mGluR1α became progressively concentrated in the molecular layer, particularly in the synaptic specialisations. As a result, during the fourth postnatal week, the pattern and level of mGluR1α expression became similar to the adult and mGluR1α appeared in high density in perisynaptic sites. Our results indicate that mGluR1α is present in the developing Purkinje cells prior to their innervation by climbing and parallel fibres and demonstrate that this receptor undergoes a dynamic and specific regulation during postnatal development in association with the establishment of synaptic inputs to Purkinje cell.","lang":"eng"}],"intvolume":"       105","issue":"2","article_type":"original","extern":"1","language":[{"iso":"eng"}],"date_created":"2018-12-11T11:58:39Z","title":"Developmental changes in the localisation of the mGluR1α subtype of metabotropic glutamate receptors in Purkinje cells","scopus_import":"1","publist_id":"4290","type":"journal_article","day":"27","citation":{"mla":"López Bendito, Guillermina, et al. “Developmental Changes in the Localisation of the MGluR1α Subtype of Metabotropic Glutamate Receptors in Purkinje Cells.” <i>Neuroscience</i>, vol. 105, no. 2, Elsevier, 2001, pp. 413–29, doi:<a href=\"https://doi.org/10.1016/S0306-4522(01)00188-9\">10.1016/S0306-4522(01)00188-9</a>.","apa":"López Bendito, G., Shigemoto, R., Luján, R., &#38; Juíz, J. (2001). Developmental changes in the localisation of the mGluR1α subtype of metabotropic glutamate receptors in Purkinje cells. <i>Neuroscience</i>. Elsevier. <a href=\"https://doi.org/10.1016/S0306-4522(01)00188-9\">https://doi.org/10.1016/S0306-4522(01)00188-9</a>","chicago":"López Bendito, Guillermina, Ryuichi Shigemoto, Rafael Luján, and José Juíz. “Developmental Changes in the Localisation of the MGluR1α Subtype of Metabotropic Glutamate Receptors in Purkinje Cells.” <i>Neuroscience</i>. Elsevier, 2001. <a href=\"https://doi.org/10.1016/S0306-4522(01)00188-9\">https://doi.org/10.1016/S0306-4522(01)00188-9</a>.","ista":"López Bendito G, Shigemoto R, Luján R, Juíz J. 2001. Developmental changes in the localisation of the mGluR1α subtype of metabotropic glutamate receptors in Purkinje cells. Neuroscience. 105(2), 413–429.","short":"G. López Bendito, R. Shigemoto, R. Luján, J. Juíz, Neuroscience 105 (2001) 413–429.","ama":"López Bendito G, Shigemoto R, Luján R, Juíz J. Developmental changes in the localisation of the mGluR1α subtype of metabotropic glutamate receptors in Purkinje cells. <i>Neuroscience</i>. 2001;105(2):413-429. doi:<a href=\"https://doi.org/10.1016/S0306-4522(01)00188-9\">10.1016/S0306-4522(01)00188-9</a>","ieee":"G. López Bendito, R. Shigemoto, R. Luján, and J. Juíz, “Developmental changes in the localisation of the mGluR1α subtype of metabotropic glutamate receptors in Purkinje cells,” <i>Neuroscience</i>, vol. 105, no. 2. Elsevier, pp. 413–429, 2001."},"oa_version":"None","doi":"10.1016/S0306-4522(01)00188-9","quality_controlled":"1"},{"acknowledgement":"We are grateful to M. Yokoi and S. Nakanishi for kindly providing us with the mGluR2-de¢cient mice and F. Ferraguti for mGluR8b cDNA. The technical assistance of S. Doi and the photographic assistance of A. Uesugi are acknowledged. This work has been supported by research grants from the Ministry of Education, Sports, Culture, Science, and Technology of Japan.","author":[{"last_name":"Tamaru","first_name":"Y","full_name":"Tamaru, Y"},{"last_name":"Nomura","full_name":"Nomura, Sakashi","first_name":"Sakashi"},{"first_name":"Noboru","full_name":"Mizuno, Noboru","last_name":"Mizuno"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi","first_name":"Ryuichi"}],"external_id":{"pmid":["11591452"]},"page":"481 - 503","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","year":"2001","publication_identifier":{"issn":["0306-4522"]},"status":"public","date_published":"2001-09-27T00:00:00Z","date_updated":"2023-05-24T08:51:17Z","publication_status":"published","_id":"2609","publisher":"Elsevier","publication":"Neuroscience","pmid":1,"month":"09","extern":"1","issue":"3","article_type":"original","intvolume":"       106","volume":106,"abstract":[{"text":"The metabotropic glutamate receptors (mGluRs) have distinct distribution patterns in the CNS but subtypes within group I or group III mGluRs share similar ultrastructural localization relative to neurotransmitter release sites: group I mGluRs are concentrated in an annulus surrounding the edge of the postsynaptic density, whereas group III mGluRs are concentrated in the presynaptic active zone. One of the group II subtypes, mGluR2, is expressed in both pre- and postsynaptic elements, having no close association with synapses. In order to determine if such a distribution is common to another group II subtype, mGluR3, an antibody was raised against a carboxy-terminus of mGluR3 and used for light and electron microscopic immunohistochemistry in the mouse CNS. The antibody reacted strongly with mGluR3, but it also reacted, though only weakly, with mGluR2. Therefore, to examine mGluR3-selective distribution, we used mGluR2-deficient mice as well as wild-type mice. Strong immunoreactivity for mGluR3 was found in the cerebral cortex, striatum, dentate gyrus of the hippocampus, olfactory tubercle, lateral septal nucleus, lateral and basolateral amygdaloid nuclei, and nucleus of the lateral olfactory tract. Pre-embedding immunoperoxidase and immunogold methods revealed mGluR3 labeling in both presynaptic and postsynaptic elements, and also in glial profiles. Double labeling revealed that the vast majority of mGluR3 in presynaptic elements is not closely associated with glutamate and GABA release sites in the striatum and thalamus, respectively. However, in the spines of the dentate granule cells, the highest receptor density was found in perisynaptic sites (20% of immunogold particles within 60 nm from the edge of postsynaptic membrane specialization) followed by a decreasing receptor density away from the synapses (to ∼5% of particles per 60 nm). Furthermore, 19% of immunogold particles were located in asymmetrical postsynaptic specialization, indicating an association of mGluR3 to glutamatergic synapses. The present results indicate that the localization of mGluR3 is rather similar to that of group I mGluRs in the postsynaptic elements, suggesting a unique functional role of mGluR3 in glutamatergic neurotransmission in the CNS.","lang":"eng"}],"scopus_import":"1","title":"Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: Differential location relative to pre- and postsynaptic sites","date_created":"2018-12-11T11:58:39Z","language":[{"iso":"eng"}],"citation":{"mla":"Tamaru, Y., et al. “Distribution of Metabotropic Glutamate Receptor MGluR3 in the Mouse CNS: Differential Location Relative to Pre- and Postsynaptic Sites.” <i>Neuroscience</i>, vol. 106, no. 3, Elsevier, 2001, pp. 481–503, doi:<a href=\"https://doi.org/10.1016/S0306-4522(01)00305-0\">10.1016/S0306-4522(01)00305-0</a>.","ieee":"Y. Tamaru, S. Nomura, N. Mizuno, and R. Shigemoto, “Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: Differential location relative to pre- and postsynaptic sites,” <i>Neuroscience</i>, vol. 106, no. 3. Elsevier, pp. 481–503, 2001.","ama":"Tamaru Y, Nomura S, Mizuno N, Shigemoto R. Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: Differential location relative to pre- and postsynaptic sites. <i>Neuroscience</i>. 2001;106(3):481-503. doi:<a href=\"https://doi.org/10.1016/S0306-4522(01)00305-0\">10.1016/S0306-4522(01)00305-0</a>","short":"Y. Tamaru, S. Nomura, N. Mizuno, R. Shigemoto, Neuroscience 106 (2001) 481–503.","apa":"Tamaru, Y., Nomura, S., Mizuno, N., &#38; Shigemoto, R. (2001). Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: Differential location relative to pre- and postsynaptic sites. <i>Neuroscience</i>. Elsevier. <a href=\"https://doi.org/10.1016/S0306-4522(01)00305-0\">https://doi.org/10.1016/S0306-4522(01)00305-0</a>","chicago":"Tamaru, Y, Sakashi Nomura, Noboru Mizuno, and Ryuichi Shigemoto. “Distribution of Metabotropic Glutamate Receptor MGluR3 in the Mouse CNS: Differential Location Relative to Pre- and Postsynaptic Sites.” <i>Neuroscience</i>. Elsevier, 2001. <a href=\"https://doi.org/10.1016/S0306-4522(01)00305-0\">https://doi.org/10.1016/S0306-4522(01)00305-0</a>.","ista":"Tamaru Y, Nomura S, Mizuno N, Shigemoto R. 2001. Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: Differential location relative to pre- and postsynaptic sites. Neuroscience. 106(3), 481–503."},"day":"27","type":"journal_article","publist_id":"4289","quality_controlled":"1","doi":"10.1016/S0306-4522(01)00305-0","oa_version":"None"},{"doi":"10.1523/JNEUROSCI.21-22-08734.2001","quality_controlled":"1","oa_version":"Published Version","main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6762269/","open_access":"1"}],"citation":{"mla":"Sansig, Gilles, et al. “Increased Seizure Susceptibility in Mice Lacking Metabotropic Glutamate Receptor 7.” <i>Journal of Neuroscience</i>, vol. 21, no. 22, Society for Neuroscience, 2001, pp. 8734–45, doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.21-22-08734.2001\">10.1523/JNEUROSCI.21-22-08734.2001</a>.","ieee":"G. Sansig <i>et al.</i>, “Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7,” <i>Journal of Neuroscience</i>, vol. 21, no. 22. Society for Neuroscience, pp. 8734–8745, 2001.","ama":"Sansig G, Bushell T, Clarke V, et al. Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7. <i>Journal of Neuroscience</i>. 2001;21(22):8734-8745. doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.21-22-08734.2001\">10.1523/JNEUROSCI.21-22-08734.2001</a>","short":"G. Sansig, T. Bushell, V. Clarke, A. Rozov, N. Burnashev, C. Portet, F. Gasparini, M. Schmutz, K. Klebs, R. Shigemoto, P. Flor, R. Kühn, T. Knoepfel, M. Schroeder, D. Hampson, V. Collett, C. Zhang, R. Duvoisin, G. Collingridge, H. Van Der Putten, Journal of Neuroscience 21 (2001) 8734–8745.","apa":"Sansig, G., Bushell, T., Clarke, V., Rozov, A., Burnashev, N., Portet, C., … Van Der Putten, H. (2001). Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7. <i>Journal of Neuroscience</i>. Society for Neuroscience. <a href=\"https://doi.org/10.1523/JNEUROSCI.21-22-08734.2001\">https://doi.org/10.1523/JNEUROSCI.21-22-08734.2001</a>","ista":"Sansig G, Bushell T, Clarke V, Rozov A, Burnashev N, Portet C, Gasparini F, Schmutz M, Klebs K, Shigemoto R, Flor P, Kühn R, Knoepfel T, Schroeder M, Hampson D, Collett V, Zhang C, Duvoisin R, Collingridge G, Van Der Putten H. 2001. Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7. Journal of Neuroscience. 21(22), 8734–8745.","chicago":"Sansig, Gilles, Trevor Bushell, Vernon Clarke, Andrei Rozov, Nail Burnashev, Chantal Portet, Fabrizio Gasparini, et al. “Increased Seizure Susceptibility in Mice Lacking Metabotropic Glutamate Receptor 7.” <i>Journal of Neuroscience</i>. Society for Neuroscience, 2001. <a href=\"https://doi.org/10.1523/JNEUROSCI.21-22-08734.2001\">https://doi.org/10.1523/JNEUROSCI.21-22-08734.2001</a>."},"publist_id":"4288","day":"15","type":"journal_article","title":"Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7","scopus_import":"1","language":[{"iso":"eng"}],"date_created":"2018-12-11T11:58:39Z","extern":"1","intvolume":"        21","issue":"22","article_type":"original","volume":21,"abstract":[{"lang":"eng","text":"To study the role of mGlu7 receptors (mGluR7), we used homologous recombination to generate mice lacking this metabotropic receptor subtype (mGluR7 -/-). After the serendipitous discovery of a sensory stimulus-evoked epileptic phenotype, we tested two convulsant drugs, pentylenetetrazole (PTZ) and bicuculline. In animals aged 12 weeks and older, subthreshold doses of these drugs induced seizures in mGluR7 -/-, but not in mGluR7 +/-, mice. PTZ-induced seizures were inhibited by three standard anticonvulsant drugs, but not by the group III selective mGluR agonist (R,S)-4-phosphonophenylglycine (PPG). Consistent with the lack of signs of epileptic activity in the absence of specific stimuli, mGluR7 -/- mice showed no major changes in synaptic properties in two slice preparations. However, slightly increased excitability was evident in hippocampal slices. In addition, there was slower recovery from frequency facilitation in cortical slices, suggesting a role for mGluR7 as a frequency-dependent regulator in presynaptic terminals. Our findings suggest that mGluR7 receptors have a unique role in regulating neuronal excitability and that these receptors may be a novel target for the development of anticonvulsant drugs."}],"publication":"Journal of Neuroscience","pmid":1,"month":"11","publisher":"Society for Neuroscience","date_updated":"2023-05-24T08:47:53Z","publication_status":"published","_id":"2610","acknowledgement":"This work was supported in part by the Biotechnology and Biological Sciences Research Council and Medical Research Council (UK). We thank Doris Ruegg for sequencing, Gemma Texido and Klaus Rajewsky for pTV-0 DNA, J.-F. Pin for mGluR8 cDNA, K. von Figura for E14 ES cells, Pedro Grandes for histological examination of brain sections, Christoph Wiessner for help with plots and statistics, Valerie Schuler for help with Western blots, and the team of the Novartis special strain breeding facility for their support.","author":[{"last_name":"Sansig","first_name":"Gilles","full_name":"Sansig, Gilles"},{"first_name":"Trevor","full_name":"Bushell, Trevor","last_name":"Bushell"},{"first_name":"Vernon","full_name":"Clarke, Vernon","last_name":"Clarke"},{"first_name":"Andrei","full_name":"Rozov, Andrei","last_name":"Rozov"},{"full_name":"Burnashev, Nail","first_name":"Nail","last_name":"Burnashev"},{"first_name":"Chantal","full_name":"Portet, Chantal","last_name":"Portet"},{"last_name":"Gasparini","full_name":"Gasparini, Fabrizio","first_name":"Fabrizio"},{"last_name":"Schmutz","full_name":"Schmutz, Markus","first_name":"Markus"},{"last_name":"Klebs","first_name":"Klaus","full_name":"Klebs, Klaus"},{"full_name":"Shigemoto, Ryuichi","first_name":"Ryuichi","orcid":"0000-0001-8761-9444","last_name":"Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Flor, Peter","first_name":"Peter","last_name":"Flor"},{"last_name":"Kühn","full_name":"Kühn, Rainer","first_name":"Rainer"},{"first_name":"Thomas","full_name":"Knoepfel, Thomas","last_name":"Knoepfel"},{"last_name":"Schroeder","full_name":"Schroeder, Markus","first_name":"Markus"},{"first_name":"David","full_name":"Hampson, David","last_name":"Hampson"},{"first_name":"Valerie","full_name":"Collett, Valerie","last_name":"Collett"},{"last_name":"Zhang","full_name":"Zhang, Congxiao","first_name":"Congxiao"},{"first_name":"Robert","full_name":"Duvoisin, Robert","last_name":"Duvoisin"},{"full_name":"Collingridge, Graham","first_name":"Graham","last_name":"Collingridge"},{"last_name":"Van Der Putten","first_name":"Herman","full_name":"Van Der Putten, Herman"}],"external_id":{"pmid":["11698585"]},"oa":1,"article_processing_charge":"No","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","page":"8734 - 8745","date_published":"2001-11-15T00:00:00Z","status":"public","publication_identifier":{"issn":["0270-6474"]},"year":"2001"},{"_id":"2611","publication_status":"published","date_updated":"2023-05-22T12:15:44Z","year":"2001","publication_identifier":{"issn":["0306-4522"]},"date_published":"2001-12-05T00:00:00Z","status":"public","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","page":"157 - 166","article_processing_charge":"No","external_id":{"pmid":["11738139"]},"author":[{"full_name":"Ruocco, Isabella","first_name":"Isabella","last_name":"Ruocco"},{"last_name":"Cuello","full_name":"Cuello, Augusto","first_name":"Augusto"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","orcid":"0000-0001-8761-9444","first_name":"Ryuichi","full_name":"Shigemoto, Ryuichi"},{"last_name":"Ribeiro Da Silva","first_name":"Alfredo","full_name":"Ribeiro Da Silva, Alfredo"}],"acknowledgement":"The work contained in this manuscript was sponsored by the Canadian MRC, Grants # MT-12170 and MoP-38093. The authors would like to thank Sylvain Cote for technical assistance and Sid Parkinson for editorial assistance.","month":"12","pmid":1,"publication":"Neuroscience","publisher":"Elsevier","date_created":"2018-12-11T11:58:40Z","language":[{"iso":"eng"}],"scopus_import":"1","title":"Sympathectomies lead to transient substance P-immunoreactive sensory fibre plasticity in the rat skin","volume":108,"abstract":[{"text":"Research using animal models of neuropathic pain has revealed sympathetic sprouting onto dorsal root ganglion cells. More recently, sensory fibre sprouting onto dorsal root ganglion cells has also been observed. Previous work in our laboratory demonstrated persistent sympathetic fibre sprouting in the skin of the rat lower lip following sensory denervation of this region. Therefore, we applied immunocytochemistry to determine the effects of sympathectomies on the terminal fields of sensory fibres. The superior cervical ganglia were removed bilaterally and the effects on the innervation of the skin of the rat lower lip were observed 1, 2, 3, 4, 6 and 8 weeks post-surgery. Substance P and dopamine-β-hydroxylase immunoreactivities were used to identify a subset of sensory and sympathetic fibres, respectively. We also assessed neurokinin-1 receptor immunoreactivity. Quantitative data was obtained with the aid of an image analysis system. In controls, the epidermis and upper dermis were innervated by substance P-immunoreactive fibres only and upper dermal blood vessels possessed the highest density of neurokinin-1 receptor immunoreactivity. Blood vessels in the lower dermis were innervated by both substance P- and dopamine-β-hydroxylase-immunoreactive fibres. Following sympathectomies, substance P-immunoreactive fibres in the epidermis and upper dermis were more intensely labelled only 1 and 2 weeks post-surgery when compared to sham controls. The length of substance P-immunoreactive fibres in this region was also increased only on the second week. Neurokinin-1 receptor immunoreactivity in the upper dermis was slightly decreased 1 and 2 weeks post-surgery. In the lower dermis, substance P-immunoreactive fibres associated with blood vessels were more intensely labelled only 1 and 2 weeks post-surgery, and at all post-surgical time points studied, blood vessels in this region were devoid of dopamine-β-hydroxylase-immunoreactive fibres. The length of substance P-immunoreactive fibres was increased from the first to the third week post-surgery in the lower dermis. These results indicate that sympathectomies lead to transient changes in substance P-immunoreactive fibre innervation and neurokinin-1 receptor expression in rat lower lip skin. The effects are most prominent in the lower dermis probably due to a greater local concentration of nerve growth factor in this region. The plasticity of the interactions between sensory and sympathetic fibres may prove important in the regulation of skin microcirculation and in the generation of painful sensations under normal conditions or following peripheral nerve injuries.","lang":"eng"}],"article_type":"original","issue":"1","intvolume":"       108","extern":"1","oa_version":"None","quality_controlled":"1","doi":"10.1016/S0306-4522(01)00158-0","day":"05","type":"journal_article","publist_id":"4286","citation":{"mla":"Ruocco, Isabella, et al. “Sympathectomies Lead to Transient Substance P-Immunoreactive Sensory Fibre Plasticity in the Rat Skin.” <i>Neuroscience</i>, vol. 108, no. 1, Elsevier, 2001, pp. 157–66, doi:<a href=\"https://doi.org/10.1016/S0306-4522(01)00158-0\">10.1016/S0306-4522(01)00158-0</a>.","short":"I. Ruocco, A. Cuello, R. Shigemoto, A. Ribeiro Da Silva, Neuroscience 108 (2001) 157–166.","ieee":"I. Ruocco, A. Cuello, R. Shigemoto, and A. Ribeiro Da Silva, “Sympathectomies lead to transient substance P-immunoreactive sensory fibre plasticity in the rat skin,” <i>Neuroscience</i>, vol. 108, no. 1. Elsevier, pp. 157–166, 2001.","ama":"Ruocco I, Cuello A, Shigemoto R, Ribeiro Da Silva A. Sympathectomies lead to transient substance P-immunoreactive sensory fibre plasticity in the rat skin. <i>Neuroscience</i>. 2001;108(1):157-166. doi:<a href=\"https://doi.org/10.1016/S0306-4522(01)00158-0\">10.1016/S0306-4522(01)00158-0</a>","ista":"Ruocco I, Cuello A, Shigemoto R, Ribeiro Da Silva A. 2001. Sympathectomies lead to transient substance P-immunoreactive sensory fibre plasticity in the rat skin. Neuroscience. 108(1), 157–166.","chicago":"Ruocco, Isabella, Augusto Cuello, Ryuichi Shigemoto, and Alfredo Ribeiro Da Silva. “Sympathectomies Lead to Transient Substance P-Immunoreactive Sensory Fibre Plasticity in the Rat Skin.” <i>Neuroscience</i>. Elsevier, 2001. <a href=\"https://doi.org/10.1016/S0306-4522(01)00158-0\">https://doi.org/10.1016/S0306-4522(01)00158-0</a>.","apa":"Ruocco, I., Cuello, A., Shigemoto, R., &#38; Ribeiro Da Silva, A. (2001). Sympathectomies lead to transient substance P-immunoreactive sensory fibre plasticity in the rat skin. <i>Neuroscience</i>. Elsevier. <a href=\"https://doi.org/10.1016/S0306-4522(01)00158-0\">https://doi.org/10.1016/S0306-4522(01)00158-0</a>"}},{"citation":{"mla":"Li, Jin, et al. “Immunocytochemical Localization of GABAB Receptors in Mesencephalic Trigeminal Nucleus Neurons in the Rat.” <i>Neuroscience Letters</i>, vol. 315, no. 1–2, Elsevier, 2001, pp. 93–97, doi:<a href=\"https://doi.org/10.1016/S0304-3940(01)02321-7\">10.1016/S0304-3940(01)02321-7</a>.","ama":"Li J, Shigemoto R, Kulik Á, et al. Immunocytochemical localization of GABAB receptors in mesencephalic trigeminal nucleus neurons in the rat. <i>Neuroscience Letters</i>. 2001;315(1-2):93-97. doi:<a href=\"https://doi.org/10.1016/S0304-3940(01)02321-7\">10.1016/S0304-3940(01)02321-7</a>","ieee":"J. Li <i>et al.</i>, “Immunocytochemical localization of GABAB receptors in mesencephalic trigeminal nucleus neurons in the rat,” <i>Neuroscience Letters</i>, vol. 315, no. 1–2. Elsevier, pp. 93–97, 2001.","short":"J. Li, R. Shigemoto, Á. Kulik, P. Chen, S. Nomura, T. Kaneko, N. Mizuno, Neuroscience Letters 315 (2001) 93–97.","chicago":"Li, Jin, Ryuichi Shigemoto, Ákos Kulik, Peng Chen, Sakashi Nomura, Takeshi Kaneko, and Noboru Mizuno. “Immunocytochemical Localization of GABAB Receptors in Mesencephalic Trigeminal Nucleus Neurons in the Rat.” <i>Neuroscience Letters</i>. Elsevier, 2001. <a href=\"https://doi.org/10.1016/S0304-3940(01)02321-7\">https://doi.org/10.1016/S0304-3940(01)02321-7</a>.","ista":"Li J, Shigemoto R, Kulik Á, Chen P, Nomura S, Kaneko T, Mizuno N. 2001. Immunocytochemical localization of GABAB receptors in mesencephalic trigeminal nucleus neurons in the rat. Neuroscience Letters. 315(1–2), 93–97.","apa":"Li, J., Shigemoto, R., Kulik, Á., Chen, P., Nomura, S., Kaneko, T., &#38; Mizuno, N. (2001). Immunocytochemical localization of GABAB receptors in mesencephalic trigeminal nucleus neurons in the rat. <i>Neuroscience Letters</i>. Elsevier. <a href=\"https://doi.org/10.1016/S0304-3940(01)02321-7\">https://doi.org/10.1016/S0304-3940(01)02321-7</a>"},"type":"journal_article","day":"23","publist_id":"4287","oa_version":"None","quality_controlled":"1","doi":"10.1016/S0304-3940(01)02321-7","volume":315,"abstract":[{"text":"We examined immunoreactivities for γ-aminobutyric acidB-receptor (GABABR) subtypes, GABABR1 and GABABR2, in the mesencephalic trigeminal nucleus neurons (MTN neurons) of the rat. Immunoreactivity for GABABR1 was prominent in cell bodies of MTN, whereas that for GABABR2 was very weak, if existed. For electron microscopy, the immunogold-silver method for GABABR1 was combined with the immunoperoxidase method for glutamic acid decarboxylase (GAD: the synthetic enzyme of GABA). Immunogold-silver particles indicating GABABR1 immunoreactivity were distributed widely in the cytoplasm of the cell bodies postsynaptic to GAD-immunoreactive axon terminals, but were rarely associated with synaptic membrane specialization or extrasynaptic sites of plasma membrane. It has been indicated that GABABR1 may not be transported to plasma membrane when no GABABR2 exists. Thus, it was presumed that GABABR1 in the cell body of the rat MTN neurons might not be involved in the synaptic transmission.","lang":"eng"}],"extern":"1","article_type":"original","issue":"1-2","intvolume":"       315","date_created":"2018-12-11T11:58:40Z","language":[{"iso":"eng"}],"scopus_import":"1","title":"Immunocytochemical localization of GABAB receptors in mesencephalic trigeminal nucleus neurons in the rat","publisher":"Elsevier","month":"11","publication":"Neuroscience Letters","pmid":1,"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","page":"93 - 97","article_processing_charge":"No","year":"2001","publication_identifier":{"issn":["0304-3940"]},"date_published":"2001-11-23T00:00:00Z","status":"public","acknowledgement":"This work was supported in part by Grants-in-Aid from the National Natural Science Foundation of China (39870262, 39970239), from the Foundation for University Key Teacher of the Ministry of Education of China, and from the Ministry of Education, Science, Sports, Culture and Technology of Japan (12308039, 12680743).","author":[{"last_name":"Li","full_name":"Li, Jin","first_name":"Jin"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","orcid":"0000-0001-8761-9444","first_name":"Ryuichi","full_name":"Shigemoto, Ryuichi"},{"last_name":"Kulik","first_name":"Ákos","full_name":"Kulik, Ákos"},{"last_name":"Chen","full_name":"Chen, Peng","first_name":"Peng"},{"last_name":"Nomura","full_name":"Nomura, Sakashi","first_name":"Sakashi"},{"first_name":"Takeshi","full_name":"Kaneko, Takeshi","last_name":"Kaneko"},{"first_name":"Noboru","full_name":"Mizuno, Noboru","last_name":"Mizuno"}],"external_id":{"pmid":["11711223"]},"_id":"2612","date_updated":"2023-05-22T12:30:05Z","publication_status":"published"},{"publication":"13th International Congress of Mathematical Physics","quality_controlled":"1","month":"01","oa_version":"None","publisher":" International Press of Boston","citation":{"chicago":"Erdös, László. “Long Time Dynamics of an Electron in a Weakly Coupled Phonon Field.” In <i>13th International Congress of Mathematical Physics</i>, 273–81.  International Press of Boston, 2001.","ista":"Erdös L. 2001.Long time dynamics of an electron in a weakly coupled phonon field. In: 13th International Congress of Mathematical Physics. , 273–281.","apa":"Erdös, L. (2001). Long time dynamics of an electron in a weakly coupled phonon field. In <i>13th International Congress of Mathematical Physics</i> (pp. 273–281).  International Press of Boston.","ieee":"L. Erdös, “Long time dynamics of an electron in a weakly coupled phonon field,” in <i>13th International Congress of Mathematical Physics</i>,  International Press of Boston, 2001, pp. 273–281.","ama":"Erdös L. Long time dynamics of an electron in a weakly coupled phonon field. In: <i>13th International Congress of Mathematical Physics</i>.  International Press of Boston; 2001:273-281.","short":"L. Erdös, in:, 13th International Congress of Mathematical Physics,  International Press of Boston, 2001, pp. 273–281.","mla":"Erdös, László. “Long Time Dynamics of an Electron in a Weakly Coupled Phonon Field.” <i>13th International Congress of Mathematical Physics</i>,  International Press of Boston, 2001, pp. 273–81."},"publist_id":"4187","type":"book_chapter","day":"01","date_updated":"2023-05-22T12:11:29Z","publication_status":"published","title":"Long time dynamics of an electron in a weakly coupled phonon field","language":[{"iso":"eng"}],"_id":"2709","date_created":"2018-12-11T11:59:11Z","extern":"1","author":[{"id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","last_name":"Erdös","first_name":"László","full_name":"Erdös, László","orcid":"0000-0001-5366-9603"}],"article_processing_charge":"No","page":"273 - 281","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","status":"public","date_published":"2001-01-01T00:00:00Z","publication_identifier":{"isbn":["9781571460851"]},"year":"2001"},{"date_created":"2018-12-11T11:59:19Z","language":[{"iso":"eng"}],"scopus_import":"1","title":"The kernel of Dirac operators on S3 and R3","volume":13,"abstract":[{"text":"In this paper we describe an intrinsically geometric way of producing magnetic fields on S3 and R3 for which the corresponding Dirac operators have a non-trivial kernel. In many cases we are able to compute the dimension of the kernel. In particular we can give examples where the kernel has any given dimension. This generalizes the examples of Loss and Yau [1].","lang":"eng"}],"extern":"1","article_type":"original","issue":"10","intvolume":"        13","oa_version":"Published Version","quality_controlled":"1","doi":"10.1142/S0129055X01000983","citation":{"mla":"Erdös, László, and Jan Solovej. “The Kernel of Dirac Operators on S3 and R3.” <i>Reviews in Mathematical Physics</i>, vol. 13, no. 10, World Scientific Publishing, 2001, pp. 1247–80, doi:<a href=\"https://doi.org/10.1142/S0129055X01000983\">10.1142/S0129055X01000983</a>.","ista":"Erdös L, Solovej J. 2001. The kernel of Dirac operators on S3 and R3. Reviews in Mathematical Physics. 13(10), 1247–1280.","apa":"Erdös, L., &#38; Solovej, J. (2001). The kernel of Dirac operators on S3 and R3. <i>Reviews in Mathematical Physics</i>. World Scientific Publishing. <a href=\"https://doi.org/10.1142/S0129055X01000983\">https://doi.org/10.1142/S0129055X01000983</a>","chicago":"Erdös, László, and Jan Solovej. “The Kernel of Dirac Operators on S3 and R3.” <i>Reviews in Mathematical Physics</i>. World Scientific Publishing, 2001. <a href=\"https://doi.org/10.1142/S0129055X01000983\">https://doi.org/10.1142/S0129055X01000983</a>.","ieee":"L. Erdös and J. Solovej, “The kernel of Dirac operators on S3 and R3,” <i>Reviews in Mathematical Physics</i>, vol. 13, no. 10. World Scientific Publishing, pp. 1247–1280, 2001.","short":"L. Erdös, J. Solovej, Reviews in Mathematical Physics 13 (2001) 1247–1280.","ama":"Erdös L, Solovej J. The kernel of Dirac operators on S3 and R3. <i>Reviews in Mathematical Physics</i>. 2001;13(10):1247-1280. doi:<a href=\"https://doi.org/10.1142/S0129055X01000983\">10.1142/S0129055X01000983</a>"},"day":"01","type":"journal_article","publist_id":"4158","main_file_link":[{"url":"https://arxiv.org/abs/math-ph/0001036","open_access":"1"}],"_id":"2734","arxiv":1,"date_updated":"2023-05-16T12:24:25Z","publication_status":"published","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","page":"1247 - 1280","article_processing_charge":"No","year":"2001","publication_identifier":{"issn":["0129-055X"]},"status":"public","date_published":"2001-10-01T00:00:00Z","oa":1,"external_id":{"arxiv":["math-ph/0001036"]},"author":[{"orcid":"0000-0001-5366-9603","first_name":"László","full_name":"Erdös, László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","last_name":"Erdös"},{"full_name":"Solovej, Jan","first_name":"Jan","last_name":"Solovej"}],"month":"10","publication":"Reviews in Mathematical Physics","publisher":"World Scientific Publishing"},{"arxiv":1,"_id":"2735","publication_status":"published","date_updated":"2023-05-16T12:20:42Z","date_published":"2001-10-01T00:00:00Z","status":"public","year":"2001","publication_identifier":{"issn":["0044-3719"]},"article_processing_charge":"No","page":"219 - 236","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","oa":1,"external_id":{"arxiv":["math-ph/0003023"]},"author":[{"id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","last_name":"Erdös","orcid":"0000-0001-5366-9603","first_name":"László","full_name":"Erdös, László"}],"month":"10","publication":"Probability Theory and Related Fields","publisher":"Springer","language":[{"iso":"eng"}],"date_created":"2018-12-11T11:59:19Z","title":"Lifschitz tail in a magnetic field: Coexistence of classical and quantum behavior in the borderline case","scopus_import":"1","volume":121,"abstract":[{"lang":"eng","text":"We establish the exact low-energy asymptotics of the integrated density of states (Lifschitz tail) in a homogeneous magnetic field and Poissonian impurities with a repulsive single-site potential of Gaussian decay. It has been known that the Gaussian potential tail discriminates between the so-called “classical” and “quantum” regimes, and precise asymptotics are known in these cases. For the borderline case, the coexistence of the classical and quantum regimes was conjectured. Here we settle this last remaining open case to complete the full picture of the magnetic Lifschitz tails."}],"intvolume":"       121","issue":"2","article_type":"original","extern":"1","oa_version":"Published Version","quality_controlled":"1","doi":"10.1007/PL00008803","publist_id":"4157","type":"journal_article","day":"01","citation":{"mla":"Erdös, László. “Lifschitz Tail in a Magnetic Field: Coexistence of Classical and Quantum Behavior in the Borderline Case.” <i>Probability Theory and Related Fields</i>, vol. 121, no. 2, Springer, 2001, pp. 219–36, doi:<a href=\"https://doi.org/10.1007/PL00008803\">10.1007/PL00008803</a>.","ama":"Erdös L. Lifschitz tail in a magnetic field: Coexistence of classical and quantum behavior in the borderline case. <i>Probability Theory and Related Fields</i>. 2001;121(2):219-236. doi:<a href=\"https://doi.org/10.1007/PL00008803\">10.1007/PL00008803</a>","ieee":"L. Erdös, “Lifschitz tail in a magnetic field: Coexistence of classical and quantum behavior in the borderline case,” <i>Probability Theory and Related Fields</i>, vol. 121, no. 2. Springer, pp. 219–236, 2001.","short":"L. Erdös, Probability Theory and Related Fields 121 (2001) 219–236.","ista":"Erdös L. 2001. Lifschitz tail in a magnetic field: Coexistence of classical and quantum behavior in the borderline case. Probability Theory and Related Fields. 121(2), 219–236.","chicago":"Erdös, László. “Lifschitz Tail in a Magnetic Field: Coexistence of Classical and Quantum Behavior in the Borderline Case.” <i>Probability Theory and Related Fields</i>. Springer, 2001. <a href=\"https://doi.org/10.1007/PL00008803\">https://doi.org/10.1007/PL00008803</a>.","apa":"Erdös, L. (2001). Lifschitz tail in a magnetic field: Coexistence of classical and quantum behavior in the borderline case. <i>Probability Theory and Related Fields</i>. Springer. <a href=\"https://doi.org/10.1007/PL00008803\">https://doi.org/10.1007/PL00008803</a>"},"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/math-ph/0003023"}]},{"publication_status":"published","date_updated":"2023-05-16T12:12:41Z","arxiv":1,"_id":"2736","oa":1,"author":[{"id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","last_name":"Erdös","full_name":"Erdös, László","first_name":"László","orcid":"0000-0001-5366-9603"},{"first_name":"Horng","full_name":"Yau, Horng","last_name":"Yau"}],"external_id":{"arxiv":["math-ph/0111042"]},"date_published":"2001-11-01T00:00:00Z","status":"public","publication_identifier":{"issn":["1095-0761"]},"year":"2001","article_processing_charge":"No","page":"1169 - 1205","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publication":"Advances in Theoretical and Mathematical Physics","month":"11","publisher":"International Press","title":"Derivation of the nonlinear Schrödinger equation from a many body Coulomb system","scopus_import":"1","language":[{"iso":"eng"}],"date_created":"2018-12-11T11:59:20Z","intvolume":"         5","issue":"6","article_type":"original","extern":"1","volume":5,"abstract":[{"text":"We consider the time evolution of N bosonic particles interacting via a mean field Coulomb potential. Suppose the initial state is a product wavefunction. We show that at any finite time the correlation functions factorize in the limit N → ∞. Furthermore, the limiting one particle density matrix satisfies the nonlinear Hartree equation. The key ingredients are the uniqueness of the BBGKY hierarchy for the correlation functions and a new apriori estimate for the many-body Schrödinger equations.","lang":"eng"}],"doi":"10.48550/arXiv.math-ph/0111042","quality_controlled":"1","oa_version":"Published Version","main_file_link":[{"open_access":"1","url":"http://arxiv.org/abs/math-ph/0111042"}],"publist_id":"4156","day":"01","type":"journal_article","citation":{"chicago":"Erdös, László, and Horng Yau. “Derivation of the Nonlinear Schrödinger Equation from a Many Body Coulomb System.” <i>Advances in Theoretical and Mathematical Physics</i>. International Press, 2001. <a href=\"https://doi.org/10.48550/arXiv.math-ph/0111042\">https://doi.org/10.48550/arXiv.math-ph/0111042</a>.","ista":"Erdös L, Yau H. 2001. Derivation of the nonlinear Schrödinger equation from a many body Coulomb system. Advances in Theoretical and Mathematical Physics. 5(6), 1169–1205.","apa":"Erdös, L., &#38; Yau, H. (2001). Derivation of the nonlinear Schrödinger equation from a many body Coulomb system. <i>Advances in Theoretical and Mathematical Physics</i>. International Press. <a href=\"https://doi.org/10.48550/arXiv.math-ph/0111042\">https://doi.org/10.48550/arXiv.math-ph/0111042</a>","short":"L. Erdös, H. Yau, Advances in Theoretical and Mathematical Physics 5 (2001) 1169–1205.","ama":"Erdös L, Yau H. Derivation of the nonlinear Schrödinger equation from a many body Coulomb system. <i>Advances in Theoretical and Mathematical Physics</i>. 2001;5(6):1169-1205. doi:<a href=\"https://doi.org/10.48550/arXiv.math-ph/0111042\">10.48550/arXiv.math-ph/0111042</a>","ieee":"L. Erdös and H. Yau, “Derivation of the nonlinear Schrödinger equation from a many body Coulomb system,” <i>Advances in Theoretical and Mathematical Physics</i>, vol. 5, no. 6. International Press, pp. 1169–1205, 2001.","mla":"Erdös, László, and Horng Yau. “Derivation of the Nonlinear Schrödinger Equation from a Many Body Coulomb System.” <i>Advances in Theoretical and Mathematical Physics</i>, vol. 5, no. 6, International Press, 2001, pp. 1169–205, doi:<a href=\"https://doi.org/10.48550/arXiv.math-ph/0111042\">10.48550/arXiv.math-ph/0111042</a>."}},{"language":[{"iso":"eng"}],"date_created":"2018-12-11T12:00:40Z","title":"Arabidopsis thaliana Rop GTPases are localized to tips of root hairs and control polar growth","scopus_import":"1","abstract":[{"text":"Plants contain a novel unique subfamily of Rho GTPases, vital components of cellular signalling networks. Here we report a general role for some members of this family in polarized plant growth processes. We show that Arabidopsis AtRop4 and AtRop6 encode functional GTPases with similar intrinsic GTP hydrolysis rates. We localized AtRop proteins in root meristem cells to the cross-wall and cell plate membranes. Polar localization of AtRops in trichoblasts specifies the growth sites for emerging root hairs. These sites were visible before budding and elongation of the Arabidopsis root hair when AtRops accumulated at their tips. Expression of constitutively active AtRop4 and AtRop6 mutant proteins in root hairs of transgenic Arabidopsis plants abolished polarized growth and delocalized the tip-focused Ca2+ gradient. Polar localization of AtRops was inhibited by brefeldin A, but not by other drugs such as latrunculin B, cytochalasin D or caffeine. Our results demonstrate a general function of AtRop GTPases in tip growth and in polar diffuse growth.","lang":"eng"}],"volume":20,"intvolume":"        20","issue":"11","article_type":"original","extern":"1","oa_version":"Published Version","doi":"10.1093/emboj/20.11.2779","quality_controlled":"1","publist_id":"3721","type":"journal_article","day":"01","citation":{"mla":"Molendijk, Arthur, et al. “Arabidopsis Thaliana Rop GTPases Are Localized to Tips of Root Hairs and Control Polar Growth.” <i>EMBO Journal</i>, vol. 20, no. 11, Wiley-Blackwell, 2001, pp. 2779–88, doi:<a href=\"https://doi.org/10.1093/emboj/20.11.2779\">10.1093/emboj/20.11.2779</a>.","ieee":"A. Molendijk <i>et al.</i>, “Arabidopsis thaliana Rop GTPases are localized to tips of root hairs and control polar growth,” <i>EMBO Journal</i>, vol. 20, no. 11. Wiley-Blackwell, pp. 2779–2788, 2001.","short":"A. Molendijk, F. Bischoff, C. Rajendrakumar, J. Friml, M. Braun, S. Gilroy, K. Palme, EMBO Journal 20 (2001) 2779–2788.","ama":"Molendijk A, Bischoff F, Rajendrakumar C, et al. Arabidopsis thaliana Rop GTPases are localized to tips of root hairs and control polar growth. <i>EMBO Journal</i>. 2001;20(11):2779-2788. doi:<a href=\"https://doi.org/10.1093/emboj/20.11.2779\">10.1093/emboj/20.11.2779</a>","ista":"Molendijk A, Bischoff F, Rajendrakumar C, Friml J, Braun M, Gilroy S, Palme K. 2001. Arabidopsis thaliana Rop GTPases are localized to tips of root hairs and control polar growth. EMBO Journal. 20(11), 2779–2788.","chicago":"Molendijk, Arthur, Friedrich Bischoff, Chadalavada Rajendrakumar, Jiří Friml, Markus Braun, Simon Gilroy, and Klaus Palme. “Arabidopsis Thaliana Rop GTPases Are Localized to Tips of Root Hairs and Control Polar Growth.” <i>EMBO Journal</i>. Wiley-Blackwell, 2001. <a href=\"https://doi.org/10.1093/emboj/20.11.2779\">https://doi.org/10.1093/emboj/20.11.2779</a>.","apa":"Molendijk, A., Bischoff, F., Rajendrakumar, C., Friml, J., Braun, M., Gilroy, S., &#38; Palme, K. (2001). Arabidopsis thaliana Rop GTPases are localized to tips of root hairs and control polar growth. <i>EMBO Journal</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1093/emboj/20.11.2779\">https://doi.org/10.1093/emboj/20.11.2779</a>"},"main_file_link":[{"open_access":"1","url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC125484/"}],"_id":"2981","publication_status":"published","date_updated":"2023-05-16T12:07:45Z","date_published":"2001-06-01T00:00:00Z","status":"public","year":"2001","publication_identifier":{"issn":["0261-4189"]},"article_processing_charge":"No","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","page":"2779 - 2788","oa":1,"author":[{"last_name":"Molendijk","first_name":"Arthur","full_name":"Molendijk, Arthur"},{"last_name":"Bischoff","first_name":"Friedrich","full_name":"Bischoff, Friedrich"},{"last_name":"Rajendrakumar","first_name":"Chadalavada","full_name":"Rajendrakumar, Chadalavada"},{"full_name":"Friml, Jirí","first_name":"Jirí","orcid":"0000-0002-8302-7596","last_name":"Friml","id":"4159519E-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Braun, Markus","first_name":"Markus","last_name":"Braun"},{"last_name":"Gilroy","first_name":"Simon","full_name":"Gilroy, Simon"},{"full_name":"Palme, Klaus","first_name":"Klaus","last_name":"Palme"}],"external_id":{"pmid":["11387211"]},"acknowledgement":"We thank Drs Frantisek Baluška, Matthias Godde, Peter Huijser, Lars Vahlkamp and Dieter Volkmann for help, criticism and constructive reading of the manuscript. We are grateful to Dr N.-H.Chua for providing us with pTA7002. The work was funded by the DFG, the European Communities Biotechnology Programme (Bio4-CT98 0239) and the INCO Copernicus Programme (IC15-CT96-0920). C.S.V.R. is the recipient of an Alexander von Humboldt fellowship and J.F. of a DAAD fellowship.","month":"06","pmid":1,"publication":"EMBO Journal","publisher":"Wiley-Blackwell"},{"publication_status":"published","date_updated":"2023-05-16T11:59:47Z","_id":"2982","author":[{"last_name":"Gil","full_name":"Gil, Pedro","first_name":"Pedro"},{"full_name":"Dewey, Elizabeth","first_name":"Elizabeth","last_name":"Dewey"},{"orcid":"0000-0002-8302-7596","full_name":"Friml, Jirí","first_name":"Jirí","id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml"},{"last_name":"Zhao","full_name":"Zhao, Yunde","first_name":"Yunde"},{"first_name":"Kimberley","full_name":"Snowden, Kimberley","last_name":"Snowden"},{"full_name":"Putterill, Jo","first_name":"Jo","last_name":"Putterill"},{"first_name":"Klaus","full_name":"Palme, Klaus","last_name":"Palme"},{"last_name":"Estelle","full_name":"Estelle, Mark","first_name":"Mark"},{"last_name":"Chory","first_name":"Joanne","full_name":"Chory, Joanne"}],"oa":1,"external_id":{"pmid":["11485992"]},"acknowledgement":"We thank Kim Hanson and Melissa McCarthy for technical support, and Adan Colon-Carmona, Jianming Li, and Karin Schumacher for their help in generating and identifying the doc1-3 T-DNA line. Seeds of ap3-1 and a cosmid library were supplied by the ABRC stock center. Jennifer Nemhauser made useful comments concerning this manuscript. This work was supported by grants from the Department of Energy (DE-FG03-89ER13993) and the National Science Foundation (MCB96-31390) to J.C., by grants from the Department of Energy (DE-FG02-98ER20313) and the National Institutes of Health (GM43644) to M.E., by a grant from DAAD to J.F., by a grant from DFG to K.P., and by a Marsden grant of New Zealand to J.P. and K.S. J.C. is an Associate Investigator of the Howard Hughes Medical Institute (HHMI), and Y.Z. is a HHMI fellow of the Life Sciences Research Foundation.\r\n\r\nThe publication costs of this article were defrayed in part by payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 USC section 1734 solely to indicate this fact.","status":"public","date_published":"2001-08-01T00:00:00Z","publication_identifier":{"issn":["0890-9369"]},"year":"2001","article_processing_charge":"No","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","page":"1985 - 1997","pmid":1,"publication":"Genes and Development","month":"08","publisher":"Cold Spring Harbor Laboratory Press","title":"BIG: A calossin-like protein required for polar auxin transport in Arabidopsis","scopus_import":"1","language":[{"iso":"eng"}],"date_created":"2018-12-11T12:00:41Z","intvolume":"        15","article_type":"original","issue":"15","extern":"1","volume":15,"abstract":[{"text":"Polar auxin transport is crucial for the regulation of auxin action and required for some light-regulated responses during plant development. We have found that two mutants of Arabidopsis - doc1, which displays altered expression of light-regulated genes, and tir3, known for its reduced auxin transport - have similar defects and define mutations in a single gene that we have renamed BIG. BIG is very similar to the Drosophila gene Calossin/Pushover, a member of a gene family also present in Caenorhabditis elegans and human genomes. The protein encoded by BIG is extraordinary in size, 560 kD, and contains several putative Zn-finger domains. Expression-profiling experiments indicate that altered expression of multiple light-regulated genes in doc1 mutants can be suppressed by elevated levels of auxin caused by overexpression of an auxin biosynthetic gene, suggesting that normal auxin distribution is required to maintain low-level expression of these genes in the dark. Double mutants of tir3 with the auxin mutants pin1, pid, and axr1 display severe defects in auxin-dependent growth of the inflorescence. Chemical inhibitors of auxin transport change the intracellular localization of the auxin efflux carrier PIN1 in doc1/tir3 mutants, supporting the idea that BIG is required for normal auxin efflux.","lang":"eng"}],"quality_controlled":"1","doi":"10.1101/gad.905201","oa_version":"Published Version","main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC312751/"}],"publist_id":"3720","day":"01","type":"journal_article","citation":{"ama":"Gil P, Dewey E, Friml J, et al. BIG: A calossin-like protein required for polar auxin transport in Arabidopsis. <i>Genes and Development</i>. 2001;15(15):1985-1997. doi:<a href=\"https://doi.org/10.1101/gad.905201\">10.1101/gad.905201</a>","short":"P. Gil, E. Dewey, J. Friml, Y. Zhao, K. Snowden, J. Putterill, K. Palme, M. Estelle, J. Chory, Genes and Development 15 (2001) 1985–1997.","ieee":"P. Gil <i>et al.</i>, “BIG: A calossin-like protein required for polar auxin transport in Arabidopsis,” <i>Genes and Development</i>, vol. 15, no. 15. Cold Spring Harbor Laboratory Press, pp. 1985–1997, 2001.","chicago":"Gil, Pedro, Elizabeth Dewey, Jiří Friml, Yunde Zhao, Kimberley Snowden, Jo Putterill, Klaus Palme, Mark Estelle, and Joanne Chory. “BIG: A Calossin-like Protein Required for Polar Auxin Transport in Arabidopsis.” <i>Genes and Development</i>. Cold Spring Harbor Laboratory Press, 2001. <a href=\"https://doi.org/10.1101/gad.905201\">https://doi.org/10.1101/gad.905201</a>.","apa":"Gil, P., Dewey, E., Friml, J., Zhao, Y., Snowden, K., Putterill, J., … Chory, J. (2001). BIG: A calossin-like protein required for polar auxin transport in Arabidopsis. <i>Genes and Development</i>. Cold Spring Harbor Laboratory Press. <a href=\"https://doi.org/10.1101/gad.905201\">https://doi.org/10.1101/gad.905201</a>","ista":"Gil P, Dewey E, Friml J, Zhao Y, Snowden K, Putterill J, Palme K, Estelle M, Chory J. 2001. BIG: A calossin-like protein required for polar auxin transport in Arabidopsis. Genes and Development. 15(15), 1985–1997.","mla":"Gil, Pedro, et al. “BIG: A Calossin-like Protein Required for Polar Auxin Transport in Arabidopsis.” <i>Genes and Development</i>, vol. 15, no. 15, Cold Spring Harbor Laboratory Press, 2001, pp. 1985–97, doi:<a href=\"https://doi.org/10.1101/gad.905201\">10.1101/gad.905201</a>."}},{"volume":413,"abstract":[{"lang":"eng","text":"Polar transport of the phytohormone auxin mediates various processes in plant growth and development, such as apical dominance, tropisms, vascular patterning and axis formation. This view is based largely on the effects of polar auxin transport inhibitors. These compounds disrupt auxin efflux from the cell but their mode of action is unknown. It is thought that polar auxin flux is caused by the asymmetric distribution of efflux carriers acting at the plasma membrane. The polar localization of efflux carrier candidate PIN1 supports this model. Here we show that the seemingly static localization of PIN1 results from rapid actin-dependent cycling between the plasma membrane and endosomal compartments. Auxin transport inhibitors block PIN1 cycling and inhibit trafficking of membrane proteins that are unrelated to auxin transport. Our data suggest that PIN1 cycling is of central importance for auxin transport and that auxin transport inhibitors affect efflux by generally interfering with membrane-trafficking processes. In support of our conclusion, the vesicle-trafficking inhibitor brefeldin A mimics physiological effects of auxin transport inhibitors."}],"extern":"1","intvolume":"       413","issue":"6854","article_type":"letter_note","language":[{"iso":"eng"}],"date_created":"2018-12-11T12:00:41Z","title":"Auxin transport inhibitors block PIN1 cycling and vesicle trafficking","scopus_import":"1","citation":{"mla":"Geldner, Niko, et al. “Auxin Transport Inhibitors Block PIN1 Cycling and Vesicle Trafficking.” <i>Nature</i>, vol. 413, no. 6854, Nature Publishing Group, 2001, pp. 425–28, doi:<a href=\"https://doi.org/10.1038/35096571\">10.1038/35096571</a>.","chicago":"Geldner, Niko, Jiří Friml, York Stierhof, Gerd Jürgens, and Klaus Palme. “Auxin Transport Inhibitors Block PIN1 Cycling and Vesicle Trafficking.” <i>Nature</i>. Nature Publishing Group, 2001. <a href=\"https://doi.org/10.1038/35096571\">https://doi.org/10.1038/35096571</a>.","apa":"Geldner, N., Friml, J., Stierhof, Y., Jürgens, G., &#38; Palme, K. (2001). Auxin transport inhibitors block PIN1 cycling and vesicle trafficking. <i>Nature</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/35096571\">https://doi.org/10.1038/35096571</a>","ista":"Geldner N, Friml J, Stierhof Y, Jürgens G, Palme K. 2001. Auxin transport inhibitors block PIN1 cycling and vesicle trafficking. Nature. 413(6854), 425–428.","short":"N. Geldner, J. Friml, Y. Stierhof, G. Jürgens, K. Palme, Nature 413 (2001) 425–428.","ama":"Geldner N, Friml J, Stierhof Y, Jürgens G, Palme K. Auxin transport inhibitors block PIN1 cycling and vesicle trafficking. <i>Nature</i>. 2001;413(6854):425-428. doi:<a href=\"https://doi.org/10.1038/35096571\">10.1038/35096571</a>","ieee":"N. Geldner, J. Friml, Y. Stierhof, G. Jürgens, and K. Palme, “Auxin transport inhibitors block PIN1 cycling and vesicle trafficking,” <i>Nature</i>, vol. 413, no. 6854. Nature Publishing Group, pp. 425–428, 2001."},"publist_id":"3719","type":"journal_article","day":"27","oa_version":"None","quality_controlled":"1","doi":"10.1038/35096571","article_processing_charge":"No","page":"425 - 428","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_published":"2001-09-27T00:00:00Z","status":"public","publication_identifier":{"issn":["0028-0836"]},"year":"2001","external_id":{"pmid":["11574889"]},"author":[{"full_name":"Geldner, Niko","first_name":"Niko","last_name":"Geldner"},{"id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml","first_name":"Jirí","full_name":"Friml, Jirí","orcid":"0000-0002-8302-7596"},{"first_name":"York","full_name":"Stierhof, York","last_name":"Stierhof"},{"last_name":"Jürgens","first_name":"Gerd","full_name":"Jürgens, Gerd"},{"first_name":"Klaus","full_name":"Palme, Klaus","last_name":"Palme"}],"_id":"2983","date_updated":"2023-05-16T11:51:44Z","publication_status":"published","publisher":"Nature Publishing Group","month":"09","publication":"Nature","pmid":1},{"month":"10","pmid":1,"publication":"Genes and Development","publisher":"Cold Spring Harbor Laboratory Press","_id":"2984","publication_status":"published","date_updated":"2023-05-16T11:37:53Z","date_published":"2001-10-15T00:00:00Z","status":"public","year":"2001","publication_identifier":{"issn":["Genes and Development"]},"article_processing_charge":"No","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","page":"2648 - 2653","author":[{"last_name":"Swarup","first_name":"Ranjan","full_name":"Swarup, Ranjan"},{"last_name":"Friml","id":"4159519E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8302-7596","full_name":"Friml, Jirí","first_name":"Jirí"},{"first_name":"Alan","full_name":"Marchant, Alan","last_name":"Marchant"},{"full_name":"Ljung, Karin","first_name":"Karin","last_name":"Ljung"},{"full_name":"Sandberg, Göran","first_name":"Göran","last_name":"Sandberg"},{"last_name":"Palme","first_name":"Klaus","full_name":"Palme, Klaus"},{"last_name":"Bennett","first_name":"Malcolm","full_name":"Bennett, Malcolm"}],"external_id":{"pmid":["11641271"]},"oa":1,"acknowledgement":"We thank Ben Scheres and Marcus Grebe for critically reading the manuscript, Burkhard Schulz for providing advice about the HA epitope tag, and Denis Baker for valuable discussion. This work was funded by the BBSRC and European Commission grants to the LATIN and POPWOOD research consortia.\r\n\r\nThe publication costs of this article were defrayed in part by payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 USC section 1734 solely to indicate this fact.","oa_version":"Published Version","quality_controlled":"1","doi":"10.1101/gad.210501","publist_id":"3718","type":"journal_article","day":"15","citation":{"short":"R. Swarup, J. Friml, A. Marchant, K. Ljung, G. Sandberg, K. Palme, M. Bennett, Genes and Development 15 (2001) 2648–2653.","ama":"Swarup R, Friml J, Marchant A, et al. Localization of the auxin permease AUX1 suggests two functionally distinct hormone transport pathways operate in the Arabidopsis root apex. <i>Genes and Development</i>. 2001;15(20):2648-2653. doi:<a href=\"https://doi.org/10.1101/gad.210501\">10.1101/gad.210501</a>","ieee":"R. Swarup <i>et al.</i>, “Localization of the auxin permease AUX1 suggests two functionally distinct hormone transport pathways operate in the Arabidopsis root apex,” <i>Genes and Development</i>, vol. 15, no. 20. Cold Spring Harbor Laboratory Press, pp. 2648–2653, 2001.","chicago":"Swarup, Ranjan, Jiří Friml, Alan Marchant, Karin Ljung, Göran Sandberg, Klaus Palme, and Malcolm Bennett. “Localization of the Auxin Permease AUX1 Suggests Two Functionally Distinct Hormone Transport Pathways Operate in the Arabidopsis Root Apex.” <i>Genes and Development</i>. Cold Spring Harbor Laboratory Press, 2001. <a href=\"https://doi.org/10.1101/gad.210501\">https://doi.org/10.1101/gad.210501</a>.","apa":"Swarup, R., Friml, J., Marchant, A., Ljung, K., Sandberg, G., Palme, K., &#38; Bennett, M. (2001). Localization of the auxin permease AUX1 suggests two functionally distinct hormone transport pathways operate in the Arabidopsis root apex. <i>Genes and Development</i>. Cold Spring Harbor Laboratory Press. <a href=\"https://doi.org/10.1101/gad.210501\">https://doi.org/10.1101/gad.210501</a>","ista":"Swarup R, Friml J, Marchant A, Ljung K, Sandberg G, Palme K, Bennett M. 2001. Localization of the auxin permease AUX1 suggests two functionally distinct hormone transport pathways operate in the Arabidopsis root apex. Genes and Development. 15(20), 2648–2653.","mla":"Swarup, Ranjan, et al. “Localization of the Auxin Permease AUX1 Suggests Two Functionally Distinct Hormone Transport Pathways Operate in the Arabidopsis Root Apex.” <i>Genes and Development</i>, vol. 15, no. 20, Cold Spring Harbor Laboratory Press, 2001, pp. 2648–53, doi:<a href=\"https://doi.org/10.1101/gad.210501\">10.1101/gad.210501</a>."},"main_file_link":[{"open_access":"1","url":"ncbi.nlm.nih.gov/pmc/articles/PMC312818/"}],"language":[{"iso":"eng"}],"date_created":"2018-12-11T12:00:41Z","title":"Localization of the auxin permease AUX1 suggests two functionally distinct hormone transport pathways operate in the Arabidopsis root apex","scopus_import":"1","abstract":[{"lang":"eng","text":"Auxins represent an important class of plant hormone that regulate plant development. Plants use specialized carrier proteins to transport the auxin indole-3-acetic acid (IAA) to target tissues. To date, efflux carrier-mediated polar auxin transport has been assumed to represent the sole mode of long distance IAA movement. Localization of the auxin permease AUX1 in the Arabidopsis root apex has revealed a novel phloem-based IAA transport pathway. AUX1, asymmetrically localized to the plasma membrane of root protophloem cells, is proposed to promote the acropetal, post-phloem movement of auxin to the root apex. MS analysis shows that IAA accumulation in aux1 mutant root apices is impaired, consistent with an AUX1 phloem unloading function. AUX1 localization to columella and lateral root cap tissues of the Arabidopsis root apex reveals that the auxin permease regulates a second IAA transport pathway. Expression studies using an auxin-regulated reporter suggest that AUX1 is necessary for root gravitropism by facilitating basipetal auxin transport to distal elongation zone tissues."}],"volume":15,"intvolume":"        15","issue":"20","article_type":"original","extern":"1"}]