[{"year":"2002","publication_identifier":{"issn":["0036-8075"]},"publication_status":"published","date_published":"2002-05-24T00:00:00Z","quality_controlled":"1","publisher":"American Association for the Advancement of Science","page":"1466 - 1470","article_processing_charge":"No","language":[{"iso":"eng"}],"oa_version":"None","extern":"1","status":"public","publist_id":"2471","doi":"10.1126/science.1067407","abstract":[{"text":"A central problem in biology is determining how genes interact as parts of functional networks. Creation and analysis of synthetic networks, composed of well-characterized genetic elements, provide a framework for theoretical modeling. Here, with the use of a combinatorial method, a library of networks with varying connectivity was generated in Escherichia coli. These networks were composed of genes encoding the transcriptional regulators Lacl, TetR, and lambda Cl, as well as the corresponding promoters. They displayed phenotypic behaviors resembling binary logical circuits, with two chemical “inputs” and a fluorescent protein “output.” Within this simple system, diverse computational functions arose through changes in network connectivity. Combinatorial synthesis provides an alternative approach for studying biological networks, as well as an efficient method for producing diverse phenotypes in vivo.","lang":"eng"}],"publication":"Science","title":"Combinatorial synthesis of genetic networks","type":"journal_article","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_updated":"2023-07-11T12:48:53Z","author":[{"full_name":"Guet, Calin C","orcid":"0000-0001-6220-2052","first_name":"Calin C","id":"47F8433E-F248-11E8-B48F-1D18A9856A87","last_name":"Guet"},{"last_name":"Elowitz","first_name":"Michael","full_name":"Elowitz, Michael"},{"full_name":"Hsing, Weihong","last_name":"Hsing","first_name":"Weihong"},{"full_name":"Leibler, Stanislas","last_name":"Leibler","first_name":"Stanislas"}],"article_type":"original","date_created":"2018-12-11T12:05:00Z","_id":"3757","volume":296,"issue":"5572","citation":{"short":"C.C. Guet, M. Elowitz, W. Hsing, S. Leibler, Science 296 (2002) 1466–1470.","mla":"Guet, Calin C., et al. “Combinatorial Synthesis of Genetic Networks.” <i>Science</i>, vol. 296, no. 5572, American Association for the Advancement of Science, 2002, pp. 1466–70, doi:<a href=\"https://doi.org/10.1126/science.1067407\">10.1126/science.1067407</a>.","apa":"Guet, C. C., Elowitz, M., Hsing, W., &#38; Leibler, S. (2002). Combinatorial synthesis of genetic networks. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1067407\">https://doi.org/10.1126/science.1067407</a>","ista":"Guet CC, Elowitz M, Hsing W, Leibler S. 2002. Combinatorial synthesis of genetic networks. Science. 296(5572), 1466–1470.","ama":"Guet CC, Elowitz M, Hsing W, Leibler S. Combinatorial synthesis of genetic networks. <i>Science</i>. 2002;296(5572):1466-1470. doi:<a href=\"https://doi.org/10.1126/science.1067407\">10.1126/science.1067407</a>","chicago":"Guet, Calin C, Michael Elowitz, Weihong Hsing, and Stanislas Leibler. “Combinatorial Synthesis of Genetic Networks.” <i>Science</i>. American Association for the Advancement of Science, 2002. <a href=\"https://doi.org/10.1126/science.1067407\">https://doi.org/10.1126/science.1067407</a>.","ieee":"C. C. Guet, M. Elowitz, W. Hsing, and S. Leibler, “Combinatorial synthesis of genetic networks,” <i>Science</i>, vol. 296, no. 5572. American Association for the Advancement of Science, pp. 1466–1470, 2002."},"scopus_import":"1","external_id":{"pmid":["12029133"]},"pmid":1,"month":"05","intvolume":"       296","day":"24"},{"abstract":[{"text":"GABAergic interneurones are diverse in their morphological and functional properties. Perisomatic inhibitory cells show fast spiking during sustained current injection, whereas dendritic inhibitory cells fire action potentials with lower frequency. We examined functional and molecular properties of K(+) channels in interneurones with horizontal dendrites in stratum oriens-alveus (OA) of the hippocampal CA1 region, which mainly comprise somatostatin-positive dendritic inhibitory cells. Voltage-gated K(+) currents in nucleated patches isolated from OA interneurones consisted of three major components: a fast delayed rectifier K(+) current component that was highly sensitive to external 4-aminopyridine (4-AP) and tetraethylammonium (TEA) (half-maximal inhibitory concentrations &lt; 0.1 mM for both blockers), a slow delayed rectifier K(+) current component that was sensitive to high concentrations of TEA, but insensitive to 4-AP, and a rapidly inactivating A-type K(+) current component that was blocked by high concentrations of 4-AP, but resistant to TEA. The relative contributions of these components to the macroscopic K(+) current were estimated as 57 +/- 5, 25 +/- 6, and 19 +/- 2 %, respectively. Dendrotoxin, a selective blocker of Kv1 channels had only minimal effects on K(+) currents in nucleated patches. Coapplication of the membrane-permeant cAMP analogue 8-(4-chlorophenylthio)-adenosine 3':5'-cyclic monophosphate (cpt-cAMP) and the phosphodiesterase blocker isobutyl-methylxanthine (IBMX) resulted in a selective inhibition of the fast delayed rectifier K(+) current component. This inhibition was absent in the presence of the protein kinase A (PKA) inhibitor H-89, implying the involvement of PKA-mediated phosphorylation. Single-cell reverse transcription-polymerase chain reaction (RT-PCR) analysis revealed a high abundance of Kv3.2 mRNA in OA interneurones, whereas the expression level of Kv3.1 mRNA was markedly lower. Similarly, RT-PCR analysis showed a high abundance of Kv4.3 mRNA, whereas Kv4.2 mRNA was undetectable. This suggests that the fast delayed rectifier K(+) current and the A-type K(+) current component are mediated predominantly by homomeric Kv3.2 and Kv4.3 channels. Selective modulation of Kv3.2 channels in OA interneurones by cAMP is likely to be an important factor regulating the activity of dendritic inhibitory cells in principal neurone-interneurone microcircuits.","lang":"eng"}],"publication":"Journal of Physiology","doi":"10.1113/jphysiol.2001.013066","title":"Gating, modulation and subunit composition of voltage-gated K(+) channels in dendritic inhibitory interneurones of rat hippocampus","type":"journal_article","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2290075/"}],"quality_controlled":"1","publisher":"Wiley-Blackwell","page":"405 - 419","year":"2002","publication_status":"published","publication_identifier":{"issn":["0022-3751"]},"date_published":"2002-01-01T00:00:00Z","oa_version":"Published Version","status":"public","extern":"1","publist_id":"2411","oa":1,"article_processing_charge":"No","language":[{"iso":"eng"}],"external_id":{"pmid":["11790809"]},"citation":{"ieee":"C. Lien, M. Martina, J. Schultz, H. Ehmke, and P. M. Jonas, “Gating, modulation and subunit composition of voltage-gated K(+) channels in dendritic inhibitory interneurones of rat hippocampus,” <i>Journal of Physiology</i>, vol. 538, no. Pt 2. Wiley-Blackwell, pp. 405–419, 2002.","short":"C. Lien, M. Martina, J. Schultz, H. Ehmke, P.M. Jonas, Journal of Physiology 538 (2002) 405–419.","apa":"Lien, C., Martina, M., Schultz, J., Ehmke, H., &#38; Jonas, P. M. (2002). Gating, modulation and subunit composition of voltage-gated K(+) channels in dendritic inhibitory interneurones of rat hippocampus. <i>Journal of Physiology</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1113/jphysiol.2001.013066\">https://doi.org/10.1113/jphysiol.2001.013066</a>","mla":"Lien, Cheng, et al. “Gating, Modulation and Subunit Composition of Voltage-Gated K(+) Channels in Dendritic Inhibitory Interneurones of Rat Hippocampus.” <i>Journal of Physiology</i>, vol. 538, no. Pt 2, Wiley-Blackwell, 2002, pp. 405–19, doi:<a href=\"https://doi.org/10.1113/jphysiol.2001.013066\">10.1113/jphysiol.2001.013066</a>.","chicago":"Lien, Cheng, Marco Martina, Jobst Schultz, Heimo Ehmke, and Peter M Jonas. “Gating, Modulation and Subunit Composition of Voltage-Gated K(+) Channels in Dendritic Inhibitory Interneurones of Rat Hippocampus.” <i>Journal of Physiology</i>. Wiley-Blackwell, 2002. <a href=\"https://doi.org/10.1113/jphysiol.2001.013066\">https://doi.org/10.1113/jphysiol.2001.013066</a>.","ista":"Lien C, Martina M, Schultz J, Ehmke H, Jonas PM. 2002. Gating, modulation and subunit composition of voltage-gated K(+) channels in dendritic inhibitory interneurones of rat hippocampus. Journal of Physiology. 538(Pt 2), 405–419.","ama":"Lien C, Martina M, Schultz J, Ehmke H, Jonas PM. Gating, modulation and subunit composition of voltage-gated K(+) channels in dendritic inhibitory interneurones of rat hippocampus. <i>Journal of Physiology</i>. 2002;538(Pt 2):405-419. doi:<a href=\"https://doi.org/10.1113/jphysiol.2001.013066\">10.1113/jphysiol.2001.013066</a>"},"intvolume":"       538","day":"01","pmid":1,"month":"01","article_type":"original","author":[{"last_name":"Lien","first_name":"Cheng","full_name":"Lien, Cheng"},{"full_name":"Martina, Marco","last_name":"Martina","first_name":"Marco"},{"last_name":"Schultz","first_name":"Jobst","full_name":"Schultz, Jobst"},{"full_name":"Ehmke, Heimo","first_name":"Heimo","last_name":"Ehmke"},{"first_name":"Peter M","last_name":"Jonas","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5001-4804","full_name":"Jonas, Peter M"}],"date_updated":"2023-07-11T12:32:26Z","volume":538,"acknowledgement":"We thank Drs J. Bischofberger, M. Heckmann, and I. Vida for critically reading the manuscript, and A. Blomenkamp and K. Winterhalter for technical assistance. This work was supported by a scholarship from the Deutscher Akademischer Austansch dienst to C.-C. L., a Deutsche Forschungsgemeinschaft grant to P. J. (SFB 505/C5), and the Alexander-von-Humboldt foundation.","issue":"Pt 2","date_created":"2018-12-11T12:05:14Z","_id":"3799"},{"acknowledgement":"We thank Drs. J. Bischofberger, M. Heckmann, and R. Traub for critically reading the manuscript. This work was supported by Deutsche Forschungsgemeinschaft Grants SFB 505/C5 (to P.J.) and SFB 505/C6 (to M.F. and P.J.), Human Frontiers Science Program Organization Grant RG0017/1998-B (to P.J.), and grants from the Alexander-von-Humboldt Foundation (to P.J. and M.F.), the Schilling Foundation (to H.M.), and Novartis (to H.M.).","volume":99,"issue":"20","date_created":"2018-12-11T12:05:14Z","_id":"3800","author":[{"first_name":"Marlene","last_name":"Bartos","full_name":"Bartos, Marlene"},{"full_name":"Vida, Imre","first_name":"Imre","last_name":"Vida"},{"last_name":"Frotscher","first_name":"Michael","full_name":"Frotscher, Michael"},{"last_name":"Meyer","first_name":"Axel","full_name":"Meyer, Axel"},{"first_name":"Hannah","last_name":"Monyer","full_name":"Monyer, Hannah"},{"last_name":"Geiger","first_name":"Jörg","full_name":"Geiger, Jörg"},{"id":"353C1B58-F248-11E8-B48F-1D18A9856A87","last_name":"Jonas","first_name":"Peter M","full_name":"Jonas, Peter M","orcid":"0000-0001-5001-4804"}],"article_type":"original","date_updated":"2023-07-10T13:35:18Z","intvolume":"        99","day":"16","pmid":1,"month":"09","external_id":{"pmid":["12235359"]},"scopus_import":"1","citation":{"ieee":"M. Bartos <i>et al.</i>, “Fast synaptic inhibition promotes synchronized gamma oscillations in hippocampal interneuron networks,” <i>PNAS</i>, vol. 99, no. 20. National Academy of Sciences, pp. 13222–13227, 2002.","chicago":"Bartos, Marlene, Imre Vida, Michael Frotscher, Axel Meyer, Hannah Monyer, Jörg Geiger, and Peter M Jonas. “Fast Synaptic Inhibition Promotes Synchronized Gamma Oscillations in Hippocampal Interneuron Networks.” <i>PNAS</i>. National Academy of Sciences, 2002. <a href=\"https://doi.org/10.1073/pnas.192233099\">https://doi.org/10.1073/pnas.192233099</a>.","ama":"Bartos M, Vida I, Frotscher M, et al. Fast synaptic inhibition promotes synchronized gamma oscillations in hippocampal interneuron networks. <i>PNAS</i>. 2002;99(20):13222-13227. doi:<a href=\"https://doi.org/10.1073/pnas.192233099\">10.1073/pnas.192233099</a>","ista":"Bartos M, Vida I, Frotscher M, Meyer A, Monyer H, Geiger J, Jonas PM. 2002. Fast synaptic inhibition promotes synchronized gamma oscillations in hippocampal interneuron networks. PNAS. 99(20), 13222–13227.","mla":"Bartos, Marlene, et al. “Fast Synaptic Inhibition Promotes Synchronized Gamma Oscillations in Hippocampal Interneuron Networks.” <i>PNAS</i>, vol. 99, no. 20, National Academy of Sciences, 2002, pp. 13222–27, doi:<a href=\"https://doi.org/10.1073/pnas.192233099\">10.1073/pnas.192233099</a>.","apa":"Bartos, M., Vida, I., Frotscher, M., Meyer, A., Monyer, H., Geiger, J., &#38; Jonas, P. M. (2002). Fast synaptic inhibition promotes synchronized gamma oscillations in hippocampal interneuron networks. <i>PNAS</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.192233099\">https://doi.org/10.1073/pnas.192233099</a>","short":"M. Bartos, I. Vida, M. Frotscher, A. Meyer, H. Monyer, J. Geiger, P.M. Jonas, PNAS 99 (2002) 13222–13227."},"oa":1,"publist_id":"2409","oa_version":"Published Version","status":"public","extern":"1","language":[{"iso":"eng"}],"article_processing_charge":"No","page":"13222 - 13227","quality_controlled":"1","publisher":"National Academy of Sciences","date_published":"2002-09-16T00:00:00Z","year":"2002","publication_status":"published","publication_identifier":{"issn":["0027-8424"]},"main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC130614/"}],"title":"Fast synaptic inhibition promotes synchronized gamma oscillations in hippocampal interneuron networks","type":"journal_article","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publication":"PNAS","abstract":[{"text":"Networks of GABAergic interneurons are of critical importance for the generation of gamma frequency oscillations in the brain. To examine the underlying synaptic mechanisms, we made paired recordings from &quot;basket cells&quot; (BCs) in different subfields of hippocampal slices, using transgenic mice that express enhanced green fluorescent protein (EGFP) under the control of the parvalbumin promoter. Unitary inhibitory postsynaptic currents (IPSCs) showed large amplitude and fast time course with mean amplitude-weighted decay time constants of 2.5, 1.2, and 1.8 ms in the dentate gyrus, and the cornu ammonis area 3 (CA3) and 1 (CA1), respectively (33-34 degrees C). The decay of unitary IPSCs at BC-BC synapses was significantly faster than that at BC-principal cell synapses, indicating target cell-specific differences in IPSC kinetics. In addition, electrical coupling was found in a subset of BC-BC pairs. To examine whether an interneuron network with fast inhibitory synapses can act as a gamma frequency oscillator, we developed an interneuron network model based on experimentally determined properties. In comparison to previous interneuron network models, our model was able to generate oscillatory activity with higher coherence over a broad range of frequencies (20-110 Hz). In this model, high coherence and flexibility in frequency control emerge from the combination of synaptic properties, network structure, and electrical coupling.","lang":"eng"}],"doi":"10.1073/pnas.192233099"},{"doi":"10.1113/jphysiol.2001.013455","publication":"Journal of Physiology","abstract":[{"lang":"eng","text":"To examine possible interactions between fast depression and modulation of inhibitory synaptic transmission in the hippocampus, we recorded from pairs of synaptically connected basket cells (BCs) and granule cells (GCs) in the dentate gyrus of rat brain slices at 34 degrees C. Multiple-pulse depression (MPD) was examined in trains of 5 or 10 inhibitory postsynaptic currents (IPSCs) evoked at frequencies of 10-100 Hz under several conditions that inhibit transmitter release: block of voltage-dependent Ca2+ channels by Cd2+ (10 microM), activation of gamma-amino-butyric acid type B receptors (GABA(B)Rs) by baclofen (10 microM) and activation of muscarinic acetylcholine receptors (mAchRs) by carbachol (2 microM). All manipulations led to a substantial inhibition of synaptic transmission, reducing the amplitude of the first IPSC in the train (IPSC1) by 72%, 61% and 29%, respectively. However, MPD was largely preserved under these conditions (0.34 in control versus 0.31, 0.50 and 0.47 in the respective conditions at 50 Hz). Similarly, a theta burst stimulation (TBS) protocol reduced IPSC1 by 54%, but left MPD unchanged (0.40 in control and 0.39 during TBS). Analysis of both fractions of transmission failures and coefficients of variation (CV) of IPSC peak amplitudes suggested that MPD had a presynaptic expression site, independent of release probability. In conclusion, different types of presynaptic modulation of inhibitory synaptic transmission converge on a reduction of synaptic strength, while short-term dynamics are largely unchanged."}],"main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2290140/"}],"type":"journal_article","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","title":"Presynaptic short-term depression is maintained during regulation of transmitter release at a GABAergic synapse in rat hippocampus","date_published":"2002-02-01T00:00:00Z","publication_identifier":{"issn":["0022-3751"]},"year":"2002","publication_status":"published","page":"201 - 8","publisher":"Wiley-Blackwell","quality_controlled":"1","language":[{"iso":"eng"}],"article_processing_charge":"No","publist_id":"2410","oa":1,"extern":"1","status":"public","oa_version":"Published Version","scopus_import":"1","citation":{"ieee":"S. Hefft, U. Kraushaar, J. Geiger, and P. M. Jonas, “Presynaptic short-term depression is maintained during regulation of transmitter release at a GABAergic synapse in rat hippocampus,” <i>Journal of Physiology</i>, vol. 539, no. Pt 1. Wiley-Blackwell, pp. 201–8, 2002.","mla":"Hefft, Stefan, et al. “Presynaptic Short-Term Depression Is Maintained during Regulation of Transmitter Release at a GABAergic Synapse in Rat Hippocampus.” <i>Journal of Physiology</i>, vol. 539, no. Pt 1, Wiley-Blackwell, 2002, pp. 201–08, doi:<a href=\"https://doi.org/10.1113/jphysiol.2001.013455\">10.1113/jphysiol.2001.013455</a>.","short":"S. Hefft, U. Kraushaar, J. Geiger, P.M. Jonas, Journal of Physiology 539 (2002) 201–8.","apa":"Hefft, S., Kraushaar, U., Geiger, J., &#38; Jonas, P. M. (2002). Presynaptic short-term depression is maintained during regulation of transmitter release at a GABAergic synapse in rat hippocampus. <i>Journal of Physiology</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1113/jphysiol.2001.013455\">https://doi.org/10.1113/jphysiol.2001.013455</a>","chicago":"Hefft, Stefan, Udo Kraushaar, Jörg Geiger, and Peter M Jonas. “Presynaptic Short-Term Depression Is Maintained during Regulation of Transmitter Release at a GABAergic Synapse in Rat Hippocampus.” <i>Journal of Physiology</i>. Wiley-Blackwell, 2002. <a href=\"https://doi.org/10.1113/jphysiol.2001.013455\">https://doi.org/10.1113/jphysiol.2001.013455</a>.","ista":"Hefft S, Kraushaar U, Geiger J, Jonas PM. 2002. Presynaptic short-term depression is maintained during regulation of transmitter release at a GABAergic synapse in rat hippocampus. Journal of Physiology. 539(Pt 1), 201–8.","ama":"Hefft S, Kraushaar U, Geiger J, Jonas PM. Presynaptic short-term depression is maintained during regulation of transmitter release at a GABAergic synapse in rat hippocampus. <i>Journal of Physiology</i>. 2002;539(Pt 1):201-208. doi:<a href=\"https://doi.org/10.1113/jphysiol.2001.013455\">10.1113/jphysiol.2001.013455</a>"},"external_id":{"pmid":["11850513"]},"month":"02","pmid":1,"day":"01","intvolume":"       539","date_updated":"2023-07-11T10:01:12Z","author":[{"full_name":"Hefft, Stefan","first_name":"Stefan","last_name":"Hefft"},{"full_name":"Kraushaar, Udo","first_name":"Udo","last_name":"Kraushaar"},{"full_name":"Geiger, Jörg","first_name":"Jörg","last_name":"Geiger"},{"full_name":"Jonas, Peter M","orcid":"0000-0001-5001-4804","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","last_name":"Jonas","first_name":"Peter M"}],"article_type":"original","_id":"3801","date_created":"2018-12-11T12:05:15Z","issue":"Pt 1","acknowledgement":"We  thank  Drs  M.  Bartos,  J.  Bischofberger,  M.  Heckmann  and I. Vida  for  critically  reading  the  manuscript,  Dr  K.  Götz  for providing  information  about  pharmacological  properties  of inhibitory  hippocampal  synapses,  and  A.  Blomenkamp  and K. Winterhalter for technical assistance. This work was supported by Deutsche Forschungsgemeinschaft grants to P.J. (Jo-248/2-2,SFB 505/C5) and the Alexander-von-Humboldt foundation.","volume":539},{"_id":"3802","date_created":"2018-12-11T12:05:15Z","issue":"24","volume":22,"acknowledgement":"J.B. was supported by grants from the Deutsche Forschungsgemeinschaft (Bi 642/1-2 and SFB 505/C9). We thank Dr. U. Kraushaar, Dr. S. Hefft, and C. Schmidt-Hieber for critically reading this manuscript, F. Heyde for secretarial help, and A. Blomenkamp and K. Winterhalter for technical assistance.","date_updated":"2023-06-13T13:19:45Z","article_type":"original","author":[{"full_name":"Bischofberger, Josef","last_name":"Bischofberger","first_name":"Josef"},{"first_name":"Jörg","last_name":"Geiger","full_name":"Geiger, Jörg"},{"last_name":"Jonas","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","first_name":"Peter M","orcid":"0000-0001-5001-4804","full_name":"Jonas, Peter M"}],"month":"12","pmid":1,"day":"01","intvolume":"        22","scopus_import":"1","citation":{"mla":"Bischofberger, Josef, et al. “Timing and Efficacy of Ca(2+) Channel Activation in Hippocampal Mossy Fiber Boutons.” <i>Journal of Neuroscience</i>, vol. 22, no. 24, Society for Neuroscience, 2002, pp. 10593–602, doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.22-24-10593.2002\">10.1523/JNEUROSCI.22-24-10593.2002</a>.","short":"J. Bischofberger, J. Geiger, P.M. Jonas, Journal of Neuroscience 22 (2002) 10593–10602.","apa":"Bischofberger, J., Geiger, J., &#38; Jonas, P. M. (2002). Timing and efficacy of Ca(2+) channel activation in hippocampal mossy fiber boutons. <i>Journal of Neuroscience</i>. Society for Neuroscience. <a href=\"https://doi.org/10.1523/JNEUROSCI.22-24-10593.2002\">https://doi.org/10.1523/JNEUROSCI.22-24-10593.2002</a>","chicago":"Bischofberger, Josef, Jörg Geiger, and Peter M Jonas. “Timing and Efficacy of Ca(2+) Channel Activation in Hippocampal Mossy Fiber Boutons.” <i>Journal of Neuroscience</i>. Society for Neuroscience, 2002. <a href=\"https://doi.org/10.1523/JNEUROSCI.22-24-10593.2002\">https://doi.org/10.1523/JNEUROSCI.22-24-10593.2002</a>.","ista":"Bischofberger J, Geiger J, Jonas PM. 2002. Timing and efficacy of Ca(2+) channel activation in hippocampal mossy fiber boutons. Journal of Neuroscience. 22(24), 10593–10602.","ama":"Bischofberger J, Geiger J, Jonas PM. Timing and efficacy of Ca(2+) channel activation in hippocampal mossy fiber boutons. <i>Journal of Neuroscience</i>. 2002;22(24):10593-10602. doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.22-24-10593.2002\">10.1523/JNEUROSCI.22-24-10593.2002</a>","ieee":"J. Bischofberger, J. Geiger, and P. M. Jonas, “Timing and efficacy of Ca(2+) channel activation in hippocampal mossy fiber boutons,” <i>Journal of Neuroscience</i>, vol. 22, no. 24. Society for Neuroscience, pp. 10593–10602, 2002."},"external_id":{"pmid":["12486151"]},"language":[{"iso":"eng"}],"article_processing_charge":"No","publist_id":"2407","oa":1,"status":"public","extern":"1","oa_version":"Published Version","date_published":"2002-12-01T00:00:00Z","year":"2002","publication_identifier":{"issn":["0270-6474"]},"publication_status":"published","page":"10593 - 10602","publisher":"Society for Neuroscience","quality_controlled":"1","main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6758411/"}],"type":"journal_article","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","title":"Timing and efficacy of Ca(2+) channel activation in hippocampal mossy fiber boutons","doi":"10.1523/JNEUROSCI.22-24-10593.2002","publication":"Journal of Neuroscience","abstract":[{"text":"The presynaptic Ca2+ signal is a key determinant of transmitter release at chemical synapses. In cortical synaptic terminals, however, little is known about the kinetic properties of the presynaptic Ca2+ channels. To investigate the timing and magnitude of the presynaptic Ca2+ inflow, we performed whole-cell patch-clamp recordings from mossy fiber boutons (MFBs) in rat hippocampus. MFBs showed large high-voltage-activated Ca(2+) currents, with a maximal amplitude of approximately 100 pA at a membrane potential of 0 mV. Both activation and deactivation were fast, with time constants in the submillisecond range at a temperature of approximately 23 degrees C. An MFB action potential (AP) applied as a voltage-clamp command evoked a transient Ca2+ current with an average amplitude of approximately 170 pA and a half-duration of 580 microsec. A prepulse to +40 mV had only minimal effects on the AP-evoked Ca2+ current, indicating that presynaptic APs open the voltage-gated Ca2+ channels very effectively. On the basis of the experimental data, we developed a kinetic model with four closed states and one open state, linked by voltage-dependent rate constants. Simulations of the Ca2+ current could reproduce the experimental data, including the large amplitude and rapid time course of the current evoked by MFB APs. Furthermore, the simulations indicate that the shape of the presynaptic AP and the gating kinetics of the Ca2+ channels are tuned to produce a maximal Ca2+ influx during a minimal period of time. The precise timing and high efficacy of Ca2+ channel activation at this cortical glutamatergic synapse may be important for synchronous transmitter release and temporal information processing.","lang":"eng"}]},{"date_updated":"2023-07-10T13:22:24Z","article_type":"letter_note","author":[{"first_name":"Josef","last_name":"Bischofberger","full_name":"Bischofberger, Josef"},{"orcid":"0000-0001-5001-4804","full_name":"Jonas, Peter M","last_name":"Jonas","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","first_name":"Peter M"}],"date_created":"2018-12-11T12:05:15Z","_id":"3803","volume":25,"issue":"12","citation":{"ieee":"J. Bischofberger and P. M. Jonas, “TwoB or not twoB: differential transmission at glutamatergic mossy fiber-interneuron synapses in the hippocampus,” <i>Trends in Neurosciences</i>, vol. 25, no. 12. Elsevier, pp. 600–603, 2002.","chicago":"Bischofberger, Josef, and Peter M Jonas. “TwoB or Not TwoB: Differential Transmission at Glutamatergic Mossy Fiber-Interneuron Synapses in the Hippocampus.” <i>Trends in Neurosciences</i>. Elsevier, 2002. <a href=\"https://doi.org/10.1016/S0166-2236(02)02259-2\">https://doi.org/10.1016/S0166-2236(02)02259-2</a>.","ista":"Bischofberger J, Jonas PM. 2002. TwoB or not twoB: differential transmission at glutamatergic mossy fiber-interneuron synapses in the hippocampus. Trends in Neurosciences. 25(12), 600–603.","ama":"Bischofberger J, Jonas PM. TwoB or not twoB: differential transmission at glutamatergic mossy fiber-interneuron synapses in the hippocampus. <i>Trends in Neurosciences</i>. 2002;25(12):600-603. doi:<a href=\"https://doi.org/10.1016/S0166-2236(02)02259-2\">10.1016/S0166-2236(02)02259-2</a>","mla":"Bischofberger, Josef, and Peter M. Jonas. “TwoB or Not TwoB: Differential Transmission at Glutamatergic Mossy Fiber-Interneuron Synapses in the Hippocampus.” <i>Trends in Neurosciences</i>, vol. 25, no. 12, Elsevier, 2002, pp. 600–03, doi:<a href=\"https://doi.org/10.1016/S0166-2236(02)02259-2\">10.1016/S0166-2236(02)02259-2</a>.","short":"J. Bischofberger, P.M. Jonas, Trends in Neurosciences 25 (2002) 600–603.","apa":"Bischofberger, J., &#38; Jonas, P. M. (2002). TwoB or not twoB: differential transmission at glutamatergic mossy fiber-interneuron synapses in the hippocampus. <i>Trends in Neurosciences</i>. Elsevier. <a href=\"https://doi.org/10.1016/S0166-2236(02)02259-2\">https://doi.org/10.1016/S0166-2236(02)02259-2</a>"},"external_id":{"pmid":["12446120"]},"pmid":1,"month":"12","intvolume":"        25","day":"01","date_published":"2002-12-01T00:00:00Z","publication_identifier":{"issn":["0166-2236"]},"publication_status":"published","year":"2002","page":"600 - 603","quality_controlled":"1","publisher":"Elsevier","language":[{"iso":"eng"}],"article_processing_charge":"No","publist_id":"2408","oa_version":"None","extern":"1","status":"public","doi":"10.1016/S0166-2236(02)02259-2","publication":"Trends in Neurosciences","abstract":[{"text":"Mossy fiber (MF) synapses are key stations for flow of information through the hippocampal formation. A major component of the output of the MF system is directed towards inhibitory interneurons. Recent studies have revealed that the functional properties of MF-interneuron synapses differ substantially from those of MF-CA3 pyramidal neuron synapses. Mossy-fiber-interneuron synapses in the stratum lucidum represent a continuum of functional subtypes, in which the subunit composition of postsynaptic AMPA receptors and NMDA receptors appears to be regulated in a coordinated manner.","lang":"eng"}],"title":"TwoB or not twoB: differential transmission at glutamatergic mossy fiber-interneuron synapses in the hippocampus","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","type":"journal_article"},{"scopus_import":"1","citation":{"apa":"Cremer, S., &#38; Heinze, J. (2002). Adaptive production of fighter males: queens of the ant Cardiocondyla adjust the sex ratio under local mate competition. <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>. Royal Society, The. <a href=\"https://doi.org/10.1098/rspb.2001.1892\">https://doi.org/10.1098/rspb.2001.1892</a>","mla":"Cremer, Sylvia, and Jürgen Heinze. “Adaptive Production of Fighter Males: Queens of the Ant Cardiocondyla Adjust the Sex Ratio under Local Mate Competition.” <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>, vol. 269, no. 1489, Royal Society, The, 2002, pp. 417–22, doi:<a href=\"https://doi.org/10.1098/rspb.2001.1892\">10.1098/rspb.2001.1892</a>.","short":"S. Cremer, J. Heinze, Proceedings of the Royal Society of London Series B Biological Sciences 269 (2002) 417–422.","chicago":"Cremer, Sylvia, and Jürgen Heinze. “Adaptive Production of Fighter Males: Queens of the Ant Cardiocondyla Adjust the Sex Ratio under Local Mate Competition.” <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>. Royal Society, The, 2002. <a href=\"https://doi.org/10.1098/rspb.2001.1892\">https://doi.org/10.1098/rspb.2001.1892</a>.","ama":"Cremer S, Heinze J. Adaptive production of fighter males: queens of the ant Cardiocondyla adjust the sex ratio under local mate competition. <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>. 2002;269(1489):417-422. doi:<a href=\"https://doi.org/10.1098/rspb.2001.1892\">10.1098/rspb.2001.1892</a>","ista":"Cremer S, Heinze J. 2002. Adaptive production of fighter males: queens of the ant Cardiocondyla adjust the sex ratio under local mate competition. Proceedings of the Royal Society of London Series B Biological Sciences. 269(1489), 417–422.","ieee":"S. Cremer and J. Heinze, “Adaptive production of fighter males: queens of the ant Cardiocondyla adjust the sex ratio under local mate competition,” <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>, vol. 269, no. 1489. Royal Society, The, pp. 417–422, 2002."},"external_id":{"pmid":["11886631"]},"pmid":1,"month":"02","intvolume":"       269","day":"22","date_updated":"2023-06-13T11:52:17Z","author":[{"id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","last_name":"Cremer","first_name":"Sylvia","full_name":"Cremer, Sylvia","orcid":"0000-0002-2193-3868"},{"last_name":"Heinze","first_name":"Jürgen","full_name":"Heinze, Jürgen"}],"article_type":"original","date_created":"2018-12-11T12:05:53Z","_id":"3919","volume":269,"acknowledgement":"We thank A. F. G. Bourke, J. J. Boomsma, S. Foitzik, M. Sixt,C. Anderson and C. Schubart for improving the manuscript, and  E.  Sixt  for  ant  illustrations  (figure  2).  This  study  was funded  by  the  DFG  (Deutsche  Forschungsgemeinschaft:  He1623/7-2).","issue":"1489","doi":"10.1098/rspb.2001.1892","publication":"Proceedings of the Royal Society of London Series B Biological Sciences","abstract":[{"text":"Hamilton's concept of local mate competition (LMC) is the standard model to explain female-biased sex ratios in solitary Hymenoptera. In social Hymenoptera, however, LMC has remained controversial, mainly because manipulation of sex allocation by workers in response to relatedness asymmetries is an additional powerful mechanism of female bias. Furthermore, the predominant mating systems in the social insects are thought to make LMC unlikely. Nevertheless, several species exist in which dispersal of males is limited and mating occurs in the nest. Some of these species, such as the ant Cardiocondyla obscurior, have evolved dimorphic males, with one morph being specialized for dispersal and the other for fighting with nest-mate males over access to females. Such life history, combining sociality and alternative reproductive tactics in males, provides a unique opportunity to test the power of LMC as a selective force leading to female-biased sex ratios in social Hymenoptera. We show that, in concordance with LMC predictions, an experimental increase in queen number leads to a shift in sex allocation in favour of non-dispersing males, but does not influence the proportion of disperser males. Furthermore, we can assign this change in sex allocation at the colony level to the queens and rule out worker manipulation.","lang":"eng"}],"main_file_link":[{"open_access":"1","url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1690910/"}],"title":"Adaptive production of fighter males: queens of the ant Cardiocondyla adjust the sex ratio under local mate competition","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","type":"journal_article","date_published":"2002-02-22T00:00:00Z","publication_identifier":{"issn":["0962-8452"]},"year":"2002","publication_status":"published","page":"417 - 422","quality_controlled":"1","publisher":"Royal Society, The","language":[{"iso":"eng"}],"article_processing_charge":"No","oa":1,"publist_id":"2231","oa_version":"None","status":"public","extern":"1"},{"abstract":[{"lang":"eng","text":"A particular Solid Injector needle, suitable for GC-MS analyses of small specimens, is described together with its application in a study on ants."}],"publication":"Insect Social Life","citation":{"ieee":"S. Turillazzi, M. Sledge, S. Cremer, and J. Heinze, “A method for analysing small-size specimens in GC-MS,” <i>Insect Social Life</i>, vol. 4. Elsevier, pp. 169–175, 2002.","chicago":"Turillazzi, Stefano, Matthew Sledge, Sylvia Cremer, and Jürgen Heinze. “A Method for Analysing Small-Size Specimens in GC-MS.” <i>Insect Social Life</i>. Elsevier, 2002.","ama":"Turillazzi S, Sledge M, Cremer S, Heinze J. A method for analysing small-size specimens in GC-MS. <i>Insect Social Life</i>. 2002;4:169-175.","ista":"Turillazzi S, Sledge M, Cremer S, Heinze J. 2002. A method for analysing small-size specimens in GC-MS. Insect Social Life. 4, 169–175.","apa":"Turillazzi, S., Sledge, M., Cremer, S., &#38; Heinze, J. (2002). A method for analysing small-size specimens in GC-MS. <i>Insect Social Life</i>. Elsevier.","short":"S. Turillazzi, M. Sledge, S. Cremer, J. Heinze, Insect Social Life 4 (2002) 169–175.","mla":"Turillazzi, Stefano, et al. “A Method for Analysing Small-Size Specimens in GC-MS.” <i>Insect Social Life</i>, vol. 4, Elsevier, 2002, pp. 169–75."},"intvolume":"         4","title":"A method for analysing small-size specimens in GC-MS","type":"journal_article","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","day":"01","month":"01","quality_controlled":"1","article_type":"original","author":[{"first_name":"Stefano","last_name":"Turillazzi","full_name":"Turillazzi, Stefano"},{"full_name":"Sledge, Matthew","last_name":"Sledge","first_name":"Matthew"},{"last_name":"Cremer","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","first_name":"Sylvia","orcid":"0000-0002-2193-3868","full_name":"Cremer, Sylvia"},{"last_name":"Heinze","first_name":"Jürgen","full_name":"Heinze, Jürgen"}],"publisher":"Elsevier","page":"169 - 175","publication_status":"published","year":"2002","date_updated":"2023-06-13T12:57:06Z","date_published":"2002-01-01T00:00:00Z","oa_version":"None","status":"public","extern":"1","volume":4,"acknowledgement":"We thank Giancarlo Bucelli and Gloriano Moneti (Centro Interdipartimentale\r\ndi Spettrometria di Massa, Università di Firenze) for their help. Funding was\r\nprovided by the MURST “60%” and Italian CNR “40%” funds, as well as through\r\nthe research network “Social evolution” of the Universities of Aarhus, Firenze,\r\nKeele, Sheffield, Uppsala, Würzburg and the ETH of Zürich financed by the\r\nEuropean commission via the Training and Mobility of Researchers (TMR)\r\nprogramme. ","publist_id":"2232","article_processing_charge":"No","language":[{"iso":"eng"}],"date_created":"2018-12-11T12:05:54Z","_id":"3920"},{"citation":{"chicago":"Cremer, Sylvia, Birgit Lautenschläger, and Jürgen Heinze. “A Transitional Stage between the Ergatoid and Winged Male Morph in the Ant Cardiocondyla Obscurior.” <i>Insectes Sociaux</i>. Springer, 2002. <a href=\"https://doi.org/10.1007/s00040-002-8305-z\">https://doi.org/10.1007/s00040-002-8305-z</a>.","ama":"Cremer S, Lautenschläger B, Heinze J. A transitional stage between the ergatoid and winged male morph in the ant Cardiocondyla obscurior. <i>Insectes Sociaux</i>. 2002;49(3):221-228. doi:<a href=\"https://doi.org/10.1007/s00040-002-8305-z\">10.1007/s00040-002-8305-z</a>","ista":"Cremer S, Lautenschläger B, Heinze J. 2002. A transitional stage between the ergatoid and winged male morph in the ant Cardiocondyla obscurior. Insectes Sociaux. 49(3), 221–228.","apa":"Cremer, S., Lautenschläger, B., &#38; Heinze, J. (2002). A transitional stage between the ergatoid and winged male morph in the ant Cardiocondyla obscurior. <i>Insectes Sociaux</i>. Springer. <a href=\"https://doi.org/10.1007/s00040-002-8305-z\">https://doi.org/10.1007/s00040-002-8305-z</a>","short":"S. Cremer, B. Lautenschläger, J. Heinze, Insectes Sociaux 49 (2002) 221–228.","mla":"Cremer, Sylvia, et al. “A Transitional Stage between the Ergatoid and Winged Male Morph in the Ant Cardiocondyla Obscurior.” <i>Insectes Sociaux</i>, vol. 49, no. 3, Springer, 2002, pp. 221–28, doi:<a href=\"https://doi.org/10.1007/s00040-002-8305-z\">10.1007/s00040-002-8305-z</a>.","ieee":"S. Cremer, B. Lautenschläger, and J. Heinze, “A transitional stage between the ergatoid and winged male morph in the ant Cardiocondyla obscurior,” <i>Insectes Sociaux</i>, vol. 49, no. 3. Springer, pp. 221–228, 2002."},"scopus_import":"1","day":"05","intvolume":"        49","month":"04","author":[{"id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","last_name":"Cremer","first_name":"Sylvia","full_name":"Cremer, Sylvia","orcid":"0000-0002-2193-3868"},{"full_name":"Lautenschläger, Birgit","first_name":"Birgit","last_name":"Lautenschläger"},{"full_name":"Heinze, Jürgen","first_name":"Jürgen","last_name":"Heinze"}],"article_type":"original","date_updated":"2023-06-13T11:44:08Z","issue":"3","volume":49,"acknowledgement":"We would like to thank S. Karpeles for histological analysis of the winged males and S. Buchhauser for help with the photographs. This study was funded by the DFG (grant He1623/12–1).","_id":"3924","date_created":"2018-12-11T12:05:55Z","abstract":[{"lang":"eng","text":"Males of the ant Cardiocondyla show a dispersal dimorphism of a winged and wingless morph. The loss of flight has lead to morphological reductions in the wingless (ergatoid) males and also affected body size, eye size and pigmentation. As ergatoid males mate exclusively inside the maternal nest, they underlie increased male-male competition and therefore have also evolved additional changes in behaviour and physiology: in contrast to winged males, ergatoid males are highly aggressive towards each other and their spermatogenesis is prolonged compared to all other hymenopteran males. In addition to these two male morphs, we found males with an intermediate appearance. These &quot;intermorphic&quot; males provide a transitional stage between normal males in most investigated morphological and physiological parameters. As they are produced extremely rarely and only in colonies that switch between pure ergatoid to mixed male production, we argue that they likely represent a developmental mistake. Parallels between the determination of male morphs and female castes (queen-worker dimorphism and worker polymorphism) might help to understand how the large potential of phenotypic plasticity in both sexes of social insects is realised during development."}],"publication":"Insectes Sociaux","doi":"10.1007/s00040-002-8305-z","type":"journal_article","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","title":"A transitional stage between the ergatoid and winged male morph in the ant Cardiocondyla obscurior","publisher":"Springer","quality_controlled":"1","page":"221 - 228","publication_status":"published","year":"2002","publication_identifier":{"issn":["0020-1812"]},"date_published":"2002-04-05T00:00:00Z","extern":"1","status":"public","oa_version":"None","publist_id":"2229","article_processing_charge":"No","language":[{"iso":"eng"}]},{"doi":"10.1038/419897a","abstract":[{"text":"Males of the tropical ant Cardiocondyla obscurior are either wingless and aggressive or winged and docile, and both compete for access to virgin queens in the nest1, 2. Although the fighter males (ergatoids) attack and kill other ergatoids, they tolerate and even attempt to mate with their winged rivals. Here we show that the winged males avoid the aggression of wingless males by mimicking the chemical bouquet of virgin queens, but that their mating success is not reduced as a result. This example of female mimicry by vigorous males is surprising, as in other species it is typically used as a protective strategy by weaker males, and may explain the coexistence and equal mating success of two male morphs.","lang":"eng"}],"publication":"Nature","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","type":"journal_article","title":"Chemical mimicry: Male ants disguised by the queen's bouquet","year":"2002","publication_status":"published","publication_identifier":{"issn":["0028-0836"]},"date_published":"2002-10-31T00:00:00Z","publisher":"Nature Publishing Group","quality_controlled":"1","page":"897 - 897","article_processing_charge":"No","language":[{"iso":"eng"}],"extern":"1","status":"public","oa_version":"None","publist_id":"2230","citation":{"apa":"Cremer, S., Sledge, M., &#38; Heinze, J. (2002). Chemical mimicry: Male ants disguised by the queen’s bouquet. <i>Nature</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/419897a\">https://doi.org/10.1038/419897a</a>","mla":"Cremer, Sylvia, et al. “Chemical Mimicry: Male Ants Disguised by the Queen’s Bouquet.” <i>Nature</i>, vol. 419, Nature Publishing Group, 2002, pp. 897–897, doi:<a href=\"https://doi.org/10.1038/419897a\">10.1038/419897a</a>.","short":"S. Cremer, M. Sledge, J. Heinze, Nature 419 (2002) 897–897.","ista":"Cremer S, Sledge M, Heinze J. 2002. Chemical mimicry: Male ants disguised by the queen’s bouquet. Nature. 419, 897–897.","chicago":"Cremer, Sylvia, Matthew Sledge, and Jürgen Heinze. “Chemical Mimicry: Male Ants Disguised by the Queen’s Bouquet.” <i>Nature</i>. Nature Publishing Group, 2002. <a href=\"https://doi.org/10.1038/419897a\">https://doi.org/10.1038/419897a</a>.","ama":"Cremer S, Sledge M, Heinze J. Chemical mimicry: Male ants disguised by the queen’s bouquet. <i>Nature</i>. 2002;419:897-897. doi:<a href=\"https://doi.org/10.1038/419897a\">10.1038/419897a</a>","ieee":"S. Cremer, M. Sledge, and J. Heinze, “Chemical mimicry: Male ants disguised by the queen’s bouquet,” <i>Nature</i>, vol. 419. Nature Publishing Group, pp. 897–897, 2002."},"scopus_import":"1","external_id":{"pmid":["12410300"]},"month":"10","pmid":1,"day":"31","intvolume":"       419","date_updated":"2023-06-13T11:47:19Z","article_type":"original","author":[{"last_name":"Cremer","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","first_name":"Sylvia","orcid":"0000-0002-2193-3868","full_name":"Cremer, Sylvia"},{"full_name":"Sledge, Matthew","last_name":"Sledge","first_name":"Matthew"},{"last_name":"Heinze","first_name":"Jürgen","full_name":"Heinze, Jürgen"}],"_id":"3925","date_created":"2018-12-11T12:05:55Z","volume":419},{"article_processing_charge":"No","language":[{"iso":"eng"}],"extern":"1","status":"public","oa_version":"None","publist_id":"2129","publication_identifier":{"issn":["0360-0300"]},"publication_status":"published","year":"2002","date_published":"2002-12-01T00:00:00Z","publisher":"ACM","quality_controlled":"1","page":"550 - 572","type":"journal_article","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","title":"Algorithmic issues in modeling motion","doi":"10.1145/592642.592647","abstract":[{"text":"This article is a survey of research areas in which motion plays a pivotal role. The aim of the article is to review current approaches to modeling motion together with related data structures and algorithms, and to summarize the challenges that lie ahead in producing a more unified theory of motion representation that would be useful across several disciplines.","lang":"eng"}],"publication":"ACM Computing Surveys","_id":"3995","date_created":"2018-12-11T12:06:20Z","issue":"4","acknowledgement":"This article is based on the report of the Workshop on Algorithmic Issues in Modeling Motion, sponsored\r\nby an NSF grant CCR-00-83-033 and an Army Research Office grant DAAD 19-00-1-0478, held on August 6\r\nand 7, 2000 at Duke University, Durham, NC.","volume":34,"date_updated":"2023-06-13T11:34:25Z","author":[{"full_name":"Agarwal, Pankaj","first_name":"Pankaj","last_name":"Agarwal"},{"last_name":"Guibas","first_name":"Leonidas","full_name":"Guibas, Leonidas"},{"first_name":"Herbert","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","last_name":"Edelsbrunner","full_name":"Edelsbrunner, Herbert","orcid":"0000-0002-9823-6833"},{"full_name":"Erickson, Jeff","last_name":"Erickson","first_name":"Jeff"},{"first_name":"Michael","last_name":"Isard","full_name":"Isard, Michael"},{"full_name":"Har Peled, Sariel","last_name":"Har Peled","first_name":"Sariel"},{"first_name":"John","last_name":"Hershberger","full_name":"Hershberger, John"},{"first_name":"Christian","last_name":"Jensen","full_name":"Jensen, Christian"},{"full_name":"Kavraki, Lydia","first_name":"Lydia","last_name":"Kavraki"},{"first_name":"Patrice","last_name":"Koehl","full_name":"Koehl, Patrice"},{"full_name":"Lin, Ming","first_name":"Ming","last_name":"Lin"},{"last_name":"Manocha","first_name":"Dinesh","full_name":"Manocha, Dinesh"},{"first_name":"Dimitris","last_name":"Metaxas","full_name":"Metaxas, Dimitris"},{"full_name":"Mirtich, Brian","first_name":"Brian","last_name":"Mirtich"},{"last_name":"Mount","first_name":"David","full_name":"Mount, David"},{"full_name":"Muthukrishnan, Sankara","first_name":"Sankara","last_name":"Muthukrishnan"},{"full_name":"Pai, Dinesh","last_name":"Pai","first_name":"Dinesh"},{"full_name":"Sacks, Elisha","last_name":"Sacks","first_name":"Elisha"},{"full_name":"Snoeyink, Jack","first_name":"Jack","last_name":"Snoeyink"},{"full_name":"Suri, Subhash","last_name":"Suri","first_name":"Subhash"},{"first_name":"Ouri","last_name":"Wolefson","full_name":"Wolefson, Ouri"}],"article_type":"original","month":"12","day":"01","intvolume":"        34","citation":{"short":"P. Agarwal, L. Guibas, H. Edelsbrunner, J. Erickson, M. Isard, S. Har Peled, J. Hershberger, C. Jensen, L. Kavraki, P. Koehl, M. Lin, D. Manocha, D. Metaxas, B. Mirtich, D. Mount, S. Muthukrishnan, D. Pai, E. Sacks, J. Snoeyink, S. Suri, O. Wolefson, ACM Computing Surveys 34 (2002) 550–572.","apa":"Agarwal, P., Guibas, L., Edelsbrunner, H., Erickson, J., Isard, M., Har Peled, S., … Wolefson, O. (2002). Algorithmic issues in modeling motion. <i>ACM Computing Surveys</i>. ACM. <a href=\"https://doi.org/10.1145/592642.592647\">https://doi.org/10.1145/592642.592647</a>","mla":"Agarwal, Pankaj, et al. “Algorithmic Issues in Modeling Motion.” <i>ACM Computing Surveys</i>, vol. 34, no. 4, ACM, 2002, pp. 550–72, doi:<a href=\"https://doi.org/10.1145/592642.592647\">10.1145/592642.592647</a>.","ista":"Agarwal P, Guibas L, Edelsbrunner H, Erickson J, Isard M, Har Peled S, Hershberger J, Jensen C, Kavraki L, Koehl P, Lin M, Manocha D, Metaxas D, Mirtich B, Mount D, Muthukrishnan S, Pai D, Sacks E, Snoeyink J, Suri S, Wolefson O. 2002. Algorithmic issues in modeling motion. ACM Computing Surveys. 34(4), 550–572.","chicago":"Agarwal, Pankaj, Leonidas Guibas, Herbert Edelsbrunner, Jeff Erickson, Michael Isard, Sariel Har Peled, John Hershberger, et al. “Algorithmic Issues in Modeling Motion.” <i>ACM Computing Surveys</i>. ACM, 2002. <a href=\"https://doi.org/10.1145/592642.592647\">https://doi.org/10.1145/592642.592647</a>.","ama":"Agarwal P, Guibas L, Edelsbrunner H, et al. Algorithmic issues in modeling motion. <i>ACM Computing Surveys</i>. 2002;34(4):550-572. doi:<a href=\"https://doi.org/10.1145/592642.592647\">10.1145/592642.592647</a>","ieee":"P. Agarwal <i>et al.</i>, “Algorithmic issues in modeling motion,” <i>ACM Computing Surveys</i>, vol. 34, no. 4. ACM, pp. 550–572, 2002."},"scopus_import":"1"},{"article_type":"original","author":[{"full_name":"Edelsbrunner, Herbert","orcid":"0000-0002-9823-6833","first_name":"Herbert","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","last_name":"Edelsbrunner"},{"first_name":"David","last_name":"Letscher","full_name":"Letscher, David"},{"first_name":"Afra","last_name":"Zomorodian","full_name":"Zomorodian, Afra"}],"date_updated":"2023-06-13T11:41:19Z","issue":"4","acknowledgement":"We thank Jeff Erickson and John Harer for helpful discussions during early stages of this\r\npaper. We also thank Daniel Huson for the zeolite dataset Z, Thomas LaBean for the DNA\r\ndataset D, and the Stanford Graphics Lab for the Buddha dataset S. To generate the bone\r\ndataset B, we sampled an iso-surface generated by Dominique Attali. The volume data\r\nTopological Persistence and Simplification 533 was provided by Francoise Peyrin from CNRS CREATIS in Lyon and was issued from ¸ Synchrotron Radiation Microtomography from the ID19 beamline at ESRF in Grenoble.\r\nWe generated Fig. 17 using the Protein Explorer [6].","volume":28,"_id":"3996","date_created":"2018-12-11T12:06:20Z","citation":{"ista":"Edelsbrunner H, Letscher D, Zomorodian A. 2002. Topological persistence and simplification. Discrete &#38; Computational Geometry. 28(4), 511–533.","ama":"Edelsbrunner H, Letscher D, Zomorodian A. Topological persistence and simplification. <i>Discrete &#38; Computational Geometry</i>. 2002;28(4):511-533. doi:<a href=\"https://doi.org/10.1007/s00454-002-2885-2\">10.1007/s00454-002-2885-2</a>","chicago":"Edelsbrunner, Herbert, David Letscher, and Afra Zomorodian. “Topological Persistence and Simplification.” <i>Discrete &#38; Computational Geometry</i>. Springer, 2002. <a href=\"https://doi.org/10.1007/s00454-002-2885-2\">https://doi.org/10.1007/s00454-002-2885-2</a>.","apa":"Edelsbrunner, H., Letscher, D., &#38; Zomorodian, A. (2002). Topological persistence and simplification. <i>Discrete &#38; Computational Geometry</i>. Springer. <a href=\"https://doi.org/10.1007/s00454-002-2885-2\">https://doi.org/10.1007/s00454-002-2885-2</a>","mla":"Edelsbrunner, Herbert, et al. “Topological Persistence and Simplification.” <i>Discrete &#38; Computational Geometry</i>, vol. 28, no. 4, Springer, 2002, pp. 511–33, doi:<a href=\"https://doi.org/10.1007/s00454-002-2885-2\">10.1007/s00454-002-2885-2</a>.","short":"H. Edelsbrunner, D. Letscher, A. Zomorodian, Discrete &#38; Computational Geometry 28 (2002) 511–533.","ieee":"H. Edelsbrunner, D. Letscher, and A. Zomorodian, “Topological persistence and simplification,” <i>Discrete &#38; Computational Geometry</i>, vol. 28, no. 4. Springer, pp. 511–533, 2002."},"scopus_import":"1","day":"01","intvolume":"        28","month":"12","publisher":"Springer","quality_controlled":"1","page":"511 - 533","publication_status":"published","year":"2002","publication_identifier":{"issn":["0179-5376"]},"date_published":"2002-12-01T00:00:00Z","status":"public","extern":"1","oa_version":"None","publist_id":"2130","article_processing_charge":"No","language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"We formalize a notion of topological simplification within the framework of a filtration, which is the history of a growing complex. We classify a topological change that happens during growth as either a feature or noise depending on its lifetime or persistence within the filtration. We give fast algorithms for computing persistence and experimental evidence for their speed and utility."}],"publication":"Discrete & Computational Geometry","doi":"10.1007/s00454-002-2885-2","type":"journal_article","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","title":"Topological persistence and simplification"},{"publication_identifier":{"issn":["0177-0667"]},"year":"2002","publication_status":"published","date_published":"2002-10-01T00:00:00Z","quality_controlled":"1","publisher":"Springer","page":"229 - 240","article_processing_charge":"No","language":[{"iso":"eng"}],"oa_version":"None","extern":"1","status":"public","publist_id":"2126","doi":"10.1007/s003660200020","abstract":[{"lang":"eng","text":"We present results on a two-step improvement of mesh quality in three-dimensional Delaunay triangulations. The first step refines the triangulation by inserting sinks and eliminates tetrahedra with large circumradius over shortest edge length ratio. The second step assigns weights to the vertices to eliminate slivers. Our experimental findings provide evidence for the practical effectiveness of sliver exudation."}],"publication":"Engineering with Computers","title":"An experimental study of sliver exudation","type":"journal_article","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_updated":"2023-06-13T11:14:44Z","author":[{"id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","last_name":"Edelsbrunner","first_name":"Herbert","full_name":"Edelsbrunner, Herbert","orcid":"0000-0002-9823-6833"},{"full_name":"Guoy, Damrong","last_name":"Guoy","first_name":"Damrong"}],"article_type":"original","date_created":"2018-12-11T12:06:21Z","_id":"3998","acknowledgement":"NSF under grants CCR-97-12088 and DMS 98-73945, NSF under grands EIA-9972879 and CCR-00-86013 and by ARO under grant DAAG55-98-1- 0177.","volume":18,"issue":"3","citation":{"mla":"Edelsbrunner, Herbert, and Damrong Guoy. “An Experimental Study of Sliver Exudation.” <i>Engineering with Computers</i>, vol. 18, no. 3, Springer, 2002, pp. 229–40, doi:<a href=\"https://doi.org/10.1007/s003660200020\">10.1007/s003660200020</a>.","apa":"Edelsbrunner, H., &#38; Guoy, D. (2002). An experimental study of sliver exudation. <i>Engineering with Computers</i>. Springer. <a href=\"https://doi.org/10.1007/s003660200020\">https://doi.org/10.1007/s003660200020</a>","short":"H. Edelsbrunner, D. Guoy, Engineering with Computers 18 (2002) 229–240.","ama":"Edelsbrunner H, Guoy D. An experimental study of sliver exudation. <i>Engineering with Computers</i>. 2002;18(3):229-240. doi:<a href=\"https://doi.org/10.1007/s003660200020\">10.1007/s003660200020</a>","ista":"Edelsbrunner H, Guoy D. 2002. An experimental study of sliver exudation. Engineering with Computers. 18(3), 229–240.","chicago":"Edelsbrunner, Herbert, and Damrong Guoy. “An Experimental Study of Sliver Exudation.” <i>Engineering with Computers</i>. Springer, 2002. <a href=\"https://doi.org/10.1007/s003660200020\">https://doi.org/10.1007/s003660200020</a>.","ieee":"H. Edelsbrunner and D. Guoy, “An experimental study of sliver exudation,” <i>Engineering with Computers</i>, vol. 18, no. 3. Springer, pp. 229–240, 2002."},"scopus_import":"1","month":"10","intvolume":"        18","day":"01"},{"volume":12,"acknowledgement":"Center for Simulation of Advanced Rockets funded by the U.S. Department of Energy under Subcontract B341494, NSF under grant CCR-96-19542 and ARO under grant DAAG55-98-1-0177.","issue":"1-2","date_created":"2018-12-11T12:06:22Z","_id":"4000","author":[{"full_name":"Zomorodian, Afra","first_name":"Afra","last_name":"Zomorodian"},{"first_name":"Herbert","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","last_name":"Edelsbrunner","full_name":"Edelsbrunner, Herbert","orcid":"0000-0002-9823-6833"}],"article_type":"original","date_updated":"2023-06-13T11:20:09Z","intvolume":"        12","day":"01","month":"01","citation":{"ieee":"A. Zomorodian and H. Edelsbrunner, “Fast software for box intersections,” <i>International Journal of Computational Geometry and Applications</i>, vol. 12, no. 1–2. World Scientific Publishing, pp. 143–172, 2002.","apa":"Zomorodian, A., &#38; Edelsbrunner, H. (2002). Fast software for box intersections. <i>International Journal of Computational Geometry and Applications</i>. World Scientific Publishing. <a href=\"https://doi.org/10.1142/S0218195902000785\">https://doi.org/10.1142/S0218195902000785</a>","short":"A. Zomorodian, H. Edelsbrunner, International Journal of Computational Geometry and Applications 12 (2002) 143–172.","mla":"Zomorodian, Afra, and Herbert Edelsbrunner. “Fast Software for Box Intersections.” <i>International Journal of Computational Geometry and Applications</i>, vol. 12, no. 1–2, World Scientific Publishing, 2002, pp. 143–72, doi:<a href=\"https://doi.org/10.1142/S0218195902000785\">10.1142/S0218195902000785</a>.","ama":"Zomorodian A, Edelsbrunner H. Fast software for box intersections. <i>International Journal of Computational Geometry and Applications</i>. 2002;12(1-2):143-172. doi:<a href=\"https://doi.org/10.1142/S0218195902000785\">10.1142/S0218195902000785</a>","ista":"Zomorodian A, Edelsbrunner H. 2002. Fast software for box intersections. International Journal of Computational Geometry and Applications. 12(1–2), 143–172.","chicago":"Zomorodian, Afra, and Herbert Edelsbrunner. “Fast Software for Box Intersections.” <i>International Journal of Computational Geometry and Applications</i>. World Scientific Publishing, 2002. <a href=\"https://doi.org/10.1142/S0218195902000785\">https://doi.org/10.1142/S0218195902000785</a>."},"scopus_import":"1","oa_version":"None","extern":"1","status":"public","publist_id":"2128","article_processing_charge":"No","language":[{"iso":"eng"}],"quality_controlled":"1","publisher":"World Scientific Publishing","page":"143 - 172","year":"2002","publication_status":"published","publication_identifier":{"issn":["0218-1959"]},"date_published":"2002-01-01T00:00:00Z","title":"Fast software for box intersections","type":"journal_article","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","abstract":[{"lang":"eng","text":"We present fast implementations of a hybrid algorithm for reporting box and cube intersections. Our algorithm initially takes a divide-and-conquer approach and switches to simpler algorithms for low numbers of boxes. We use our implementations as engines to solve problems about geometric primitives. We look at two such problems in the category of quality analysis of surface triangulations."}],"publication":"International Journal of Computational Geometry and Applications","doi":"10.1142/S0218195902000785"},{"article_processing_charge":"No","language":[{"iso":"eng"}],"date_created":"2018-12-11T12:06:23Z","_id":"4003","oa_version":"None","extern":"1","status":"public","acknowledgement":"NSF under grants CCR-00-86013 and EIA-9972879, NSF under grant CCR-97-12088.","publist_id":"2125","publication_identifier":{"isbn":["9780898715132"]},"publication_status":"published","year":"2002","date_updated":"2023-06-07T13:50:04Z","date_published":"2002-01-01T00:00:00Z","quality_controlled":"1","author":[{"last_name":"Agarwal","first_name":"Pankaj","full_name":"Agarwal, Pankaj"},{"id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","last_name":"Edelsbrunner","first_name":"Herbert","full_name":"Edelsbrunner, Herbert","orcid":"0000-0002-9823-6833"},{"full_name":"Wang, Yusu","first_name":"Yusu","last_name":"Wang"}],"publisher":"SIAM","page":"791 - 799","month":"01","title":"Computing the writhing number of a polygonal knot","type":"conference","day":"01","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","main_file_link":[{"url":"https://dl.acm.org/doi/10.5555/545381.545485"}],"citation":{"chicago":"Agarwal, Pankaj, Herbert Edelsbrunner, and Yusu Wang. “Computing the Writhing Number of a Polygonal Knot.” In <i>Proceedings of the 13th Annual ACM-SIAM Symposium on Discrete Algorithms</i>, 791–99. SIAM, 2002.","ama":"Agarwal P, Edelsbrunner H, Wang Y. Computing the writhing number of a polygonal knot. In: <i>Proceedings of the 13th Annual ACM-SIAM Symposium on Discrete Algorithms</i>. SIAM; 2002:791-799.","ista":"Agarwal P, Edelsbrunner H, Wang Y. 2002. Computing the writhing number of a polygonal knot. Proceedings of the 13th annual ACM-SIAM symposium on Discrete algorithms. SODA: Symposium on Discrete Algorithms, 791–799.","apa":"Agarwal, P., Edelsbrunner, H., &#38; Wang, Y. (2002). Computing the writhing number of a polygonal knot. In <i>Proceedings of the 13th annual ACM-SIAM symposium on Discrete algorithms</i> (pp. 791–799). San Francisco, CA, USA: SIAM.","short":"P. Agarwal, H. Edelsbrunner, Y. Wang, in:, Proceedings of the 13th Annual ACM-SIAM Symposium on Discrete Algorithms, SIAM, 2002, pp. 791–799.","mla":"Agarwal, Pankaj, et al. “Computing the Writhing Number of a Polygonal Knot.” <i>Proceedings of the 13th Annual ACM-SIAM Symposium on Discrete Algorithms</i>, SIAM, 2002, pp. 791–99.","ieee":"P. Agarwal, H. Edelsbrunner, and Y. Wang, “Computing the writhing number of a polygonal knot,” in <i>Proceedings of the 13th annual ACM-SIAM symposium on Discrete algorithms</i>, San Francisco, CA, USA, 2002, pp. 791–799."},"scopus_import":"1","conference":{"end_date":"2002-01-08","location":"San Francisco, CA, USA","start_date":"2002-01-06","name":"SODA: Symposium on Discrete Algorithms"},"abstract":[{"text":"The writhing number measures the global geometry of a closed space curve or knot. We show that this measure is related to the average winding number of its Gauss map. Using this relationship, we give an algorithm for computing the writhing number for a polygonal knot with n edges in time roughly proportional to n(1.6). We also implement a different, simple algorithm and provide experimental evidence for its practical efficiency.","lang":"eng"}],"publication":"Proceedings of the 13th annual ACM-SIAM symposium on Discrete algorithms"},{"_id":"4139","date_created":"2018-12-11T12:07:10Z","issue":"8","volume":80,"date_updated":"2023-06-07T12:53:35Z","author":[{"orcid":"0000-0003-0951-3112","full_name":"Polechova, Jitka","last_name":"Polechova","id":"3BBFB084-F248-11E8-B48F-1D18A9856A87","first_name":"Jitka"},{"full_name":"Stopka, P.","last_name":"Stopka","first_name":"P."}],"article_type":"original","month":"01","day":"01","intvolume":"        80","scopus_import":"1","citation":{"ieee":"J. Polechova and P. Stopka, “Geometry of social relationships in the Old World wood mouse, Apodemus sylvaticus,” <i>Canadian Journal of Zoology</i>, vol. 80, no. 8. NRC Research Press, pp. 1383–1388, 2002.","short":"J. Polechova, P. Stopka, Canadian Journal of Zoology 80 (2002) 1383–1388.","apa":"Polechova, J., &#38; Stopka, P. (2002). Geometry of social relationships in the Old World wood mouse, Apodemus sylvaticus. <i>Canadian Journal of Zoology</i>. NRC Research Press. <a href=\"https://doi.org/10.1139/z02-128\">https://doi.org/10.1139/z02-128</a>","mla":"Polechova, Jitka, and P. Stopka. “Geometry of Social Relationships in the Old World Wood Mouse, Apodemus Sylvaticus.” <i>Canadian Journal of Zoology</i>, vol. 80, no. 8, NRC Research Press, 2002, pp. 1383–88, doi:<a href=\"https://doi.org/10.1139/z02-128\">10.1139/z02-128</a>.","ista":"Polechova J, Stopka P. 2002. Geometry of social relationships in the Old World wood mouse, Apodemus sylvaticus. Canadian Journal of Zoology. 80(8), 1383–1388.","ama":"Polechova J, Stopka P. Geometry of social relationships in the Old World wood mouse, Apodemus sylvaticus. <i>Canadian Journal of Zoology</i>. 2002;80(8):1383-1388. doi:<a href=\"https://doi.org/10.1139/z02-128\">10.1139/z02-128</a>","chicago":"Polechova, Jitka, and P. Stopka. “Geometry of Social Relationships in the Old World Wood Mouse, Apodemus Sylvaticus.” <i>Canadian Journal of Zoology</i>. NRC Research Press, 2002. <a href=\"https://doi.org/10.1139/z02-128\">https://doi.org/10.1139/z02-128</a>."},"language":[{"iso":"eng"}],"article_processing_charge":"No","publist_id":"1981","status":"public","extern":"1","oa_version":"None","date_published":"2002-01-01T00:00:00Z","year":"2002","publication_status":"published","publication_identifier":{"issn":["0008-4301"]},"page":"1383 - 1388","publisher":"NRC Research Press","quality_controlled":"1","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","type":"journal_article","title":"Geometry of social relationships in the Old World wood mouse, Apodemus sylvaticus","doi":"10.1139/z02-128","publication":"Canadian Journal of Zoology","abstract":[{"text":"Pilot studies in England by Stopka and Macdonald revealed that allogrooming in the Old World wood mouse, Apodemus sylvaticus, is a commodity that males can trade for reproductive benefits with females. This study, which used a combination of field study and observations in experimental enclosures, revealed that specific experimental conditions such as group-size and sex-ratio manipulations have a significant effect on the pattern of allogrooming exchanged between individuals. Furthermore, females from the Czech population were more likely to associate with each other as revealed by the clustering of activity centers of females (i.e., as opposed to almost exclusive ranges in English populations), and also by the higher intensity of allogrooming exchanged between females (i.e., virtually lacking in the previous experiment with English mice). Therefore, geographic variation and specific social conditions seem to be important driving factors for allogrooming behavior. Together with changes in overall grooming patterns, allogrooming between males and females remained invariably asymmetrical over all four experimental groups (i.e., two conditions for each sex) in that males provided more allogrooming to females than they received from them.","lang":"eng"}]},{"type":"journal_article","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","title":"Non-canonical Wnt signalling and regulation of gastrulation movements","publication":"Seminars in Cell & Developmental Biology","abstract":[{"lang":"eng","text":"Members of the Wnt family have been implicated in a variety of developmental processes including axis formation, Patterning of the central nervous system and tissue morphogenesis. Recent studies have shown that a Wnt signalling pathway similar to that involved in the establishment of planar cell polarity in Drosophila regulates convergent extension movements during zebrafish and Xenopus gastrulation. This finding provides a good starting point to dissect the complex cell biology and genetic regulation of vertebrate gastrulation movements."}],"doi":"10.1016/S1084-9521(02)00052-6","publist_id":"1973","extern":"1","status":"public","oa_version":"None","language":[{"iso":"eng"}],"article_processing_charge":"No","page":"251 - 260","publisher":"Academic Press","quality_controlled":"1","date_published":"2002-06-01T00:00:00Z","publication_status":"published","publication_identifier":{"issn":["1084-9521"]},"year":"2002","day":"01","intvolume":"        13","month":"06","pmid":1,"external_id":{"pmid":["12137734"]},"scopus_import":"1","citation":{"mla":"Tada, Masazumi, et al. “Non-Canonical Wnt Signalling and Regulation of Gastrulation Movements.” <i>Seminars in Cell &#38; Developmental Biology</i>, vol. 13, no. 3, Academic Press, 2002, pp. 251–60, doi:<a href=\"https://doi.org/10.1016/S1084-9521(02)00052-6\">10.1016/S1084-9521(02)00052-6</a>.","apa":"Tada, M., Concha, M., &#38; Heisenberg, C.-P. J. (2002). Non-canonical Wnt signalling and regulation of gastrulation movements. <i>Seminars in Cell &#38; Developmental Biology</i>. Academic Press. <a href=\"https://doi.org/10.1016/S1084-9521(02)00052-6\">https://doi.org/10.1016/S1084-9521(02)00052-6</a>","short":"M. Tada, M. Concha, C.-P.J. Heisenberg, Seminars in Cell &#38; Developmental Biology 13 (2002) 251–260.","chicago":"Tada, Masazumi, Miguel Concha, and Carl-Philipp J Heisenberg. “Non-Canonical Wnt Signalling and Regulation of Gastrulation Movements.” <i>Seminars in Cell &#38; Developmental Biology</i>. Academic Press, 2002. <a href=\"https://doi.org/10.1016/S1084-9521(02)00052-6\">https://doi.org/10.1016/S1084-9521(02)00052-6</a>.","ista":"Tada M, Concha M, Heisenberg C-PJ. 2002. Non-canonical Wnt signalling and regulation of gastrulation movements. Seminars in Cell &#38; Developmental Biology. 13(3), 251–260.","ama":"Tada M, Concha M, Heisenberg C-PJ. Non-canonical Wnt signalling and regulation of gastrulation movements. <i>Seminars in Cell &#38; Developmental Biology</i>. 2002;13(3):251-260. doi:<a href=\"https://doi.org/10.1016/S1084-9521(02)00052-6\">10.1016/S1084-9521(02)00052-6</a>","ieee":"M. Tada, M. Concha, and C.-P. J. Heisenberg, “Non-canonical Wnt signalling and regulation of gastrulation movements,” <i>Seminars in Cell &#38; Developmental Biology</i>, vol. 13, no. 3. Academic Press, pp. 251–260, 2002."},"issue":"3","volume":13,"acknowledgement":"We would like to thank Steve Wilson for encouraging us to write this article and for critical comments on this manuscript, and Lila Solnica-Krezel for communicating results prior to publication. MT is supported by an MRC Career Development Award, MLC by a Wellcome Trust Fellowship and CPH by an Emmy–Noether–Fellowship from the DFG.","_id":"4148","date_created":"2018-12-11T12:07:13Z","author":[{"full_name":"Tada, Masazumi","first_name":"Masazumi","last_name":"Tada"},{"last_name":"Concha","first_name":"Miguel","full_name":"Concha, Miguel"},{"first_name":"Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87","last_name":"Heisenberg","full_name":"Heisenberg, Carl-Philipp J","orcid":"0000-0002-0912-4566"}],"article_type":"original","date_updated":"2023-06-07T09:50:14Z"},{"_id":"4194","date_created":"2018-12-11T12:07:30Z","issue":"2","acknowledgement":"We thank many of our colleagues, especially Randy Moon, for providing  reagents  used in this study. This study was  supported by the Wellcome Trust, MRC, and BBSRC to S.W.W. and C.H. S.W.W. is a Wellcome Trust Senior Research Fellow.","volume":35,"date_updated":"2023-06-07T09:43:19Z","author":[{"full_name":"Houart, Corinne","last_name":"Houart","first_name":"Corinne"},{"last_name":"Caneparo","first_name":"Luca","full_name":"Caneparo, Luca"},{"last_name":"Heisenberg","id":"39427864-F248-11E8-B48F-1D18A9856A87","first_name":"Carl-Philipp J","orcid":"0000-0002-0912-4566","full_name":"Heisenberg, Carl-Philipp J"},{"first_name":"K Anukampa","last_name":"Barth","full_name":"Barth, K Anukampa"},{"full_name":"Take Uchi, Masaya","last_name":"Take Uchi","first_name":"Masaya"},{"full_name":"Wilson, Stephen","last_name":"Wilson","first_name":"Stephen"}],"article_type":"original","month":"07","pmid":1,"day":"18","intvolume":"        35","scopus_import":"1","citation":{"ieee":"C. Houart, L. Caneparo, C.-P. J. Heisenberg, K. A. Barth, M. Take Uchi, and S. Wilson, “Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling,” <i>Neuron</i>, vol. 35, no. 2. Elsevier, pp. 255–265, 2002.","apa":"Houart, C., Caneparo, L., Heisenberg, C.-P. J., Barth, K. A., Take Uchi, M., &#38; Wilson, S. (2002). Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling. <i>Neuron</i>. Elsevier. <a href=\"https://doi.org/10.1016/S0896-6273(02)00751-1\">https://doi.org/10.1016/S0896-6273(02)00751-1</a>","short":"C. Houart, L. Caneparo, C.-P.J. Heisenberg, K.A. Barth, M. Take Uchi, S. Wilson, Neuron 35 (2002) 255–265.","mla":"Houart, Corinne, et al. “Establishment of the Telencephalon during Gastrulation by Local Antagonism of Wnt Signaling.” <i>Neuron</i>, vol. 35, no. 2, Elsevier, 2002, pp. 255–65, doi:<a href=\"https://doi.org/10.1016/S0896-6273(02)00751-1\">10.1016/S0896-6273(02)00751-1</a>.","ama":"Houart C, Caneparo L, Heisenberg C-PJ, Barth KA, Take Uchi M, Wilson S. Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling. <i>Neuron</i>. 2002;35(2):255-265. doi:<a href=\"https://doi.org/10.1016/S0896-6273(02)00751-1\">10.1016/S0896-6273(02)00751-1</a>","ista":"Houart C, Caneparo L, Heisenberg C-PJ, Barth KA, Take Uchi M, Wilson S. 2002. Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling. Neuron. 35(2), 255–265.","chicago":"Houart, Corinne, Luca Caneparo, Carl-Philipp J Heisenberg, K Anukampa Barth, Masaya Take Uchi, and Stephen Wilson. “Establishment of the Telencephalon during Gastrulation by Local Antagonism of Wnt Signaling.” <i>Neuron</i>. Elsevier, 2002. <a href=\"https://doi.org/10.1016/S0896-6273(02)00751-1\">https://doi.org/10.1016/S0896-6273(02)00751-1</a>."},"external_id":{"pmid":["12160744"]},"language":[{"iso":"eng"}],"article_processing_charge":"No","publist_id":"1925","status":"public","extern":"1","oa_version":"None","date_published":"2002-07-18T00:00:00Z","year":"2002","publication_status":"published","publication_identifier":{"issn":["0896-6273"]},"page":"255 - 265","publisher":"Elsevier","quality_controlled":"1","type":"journal_article","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","title":"Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling","doi":"10.1016/S0896-6273(02)00751-1","publication":"Neuron","abstract":[{"lang":"eng","text":"Cells at the anterior boundary of the neural plate (ANB) can induce telencephalic gene expression when transplanted to more posterior regions. Here, we identify a secreted Frizzled-related Wnt antagonist, Tic, that is expressed in ANB cells and can cell nonautonomously promote telencephalic gene expression in a concentration-dependent manner. Moreover, abrogation of Tlc function compromises telencephalic development. We also identify Wnt8b as a locally acting modulator of regional fate in the anterior neural plate and a likely target for antagonism by Tic. Finally, we show that tlc expression is regulated by signals that establish early antero-posterior and dorso-ventral ectodermal pattern. From these studies, we propose that local antagonism of Wnt activity within the anterior ectoderm is required to establish the telencephalon."}]},{"day":"01","intvolume":"        13","month":"12","pmid":1,"external_id":{"pmid":["12468250"]},"scopus_import":"1","citation":{"ieee":"C.-P. J. Heisenberg and M. Tada, “Zebrafish gastrulation movements: bridging cell and developmental biology,” <i>Seminars in Cell &#38; Developmental Biology</i>, vol. 13, no. 6. Academic Press, pp. 471–479, 2002.","apa":"Heisenberg, C.-P. J., &#38; Tada, M. (2002). Zebrafish gastrulation movements: bridging cell and developmental biology. <i>Seminars in Cell &#38; Developmental Biology</i>. Academic Press. <a href=\"https://doi.org/10.1016/S1084952102001003\">https://doi.org/10.1016/S1084952102001003</a>","short":"C.-P.J. Heisenberg, M. Tada, Seminars in Cell &#38; Developmental Biology 13 (2002) 471–479.","mla":"Heisenberg, Carl-Philipp J., and Masazumi Tada. “Zebrafish Gastrulation Movements: Bridging Cell and Developmental Biology.” <i>Seminars in Cell &#38; Developmental Biology</i>, vol. 13, no. 6, Academic Press, 2002, pp. 471–79, doi:<a href=\"https://doi.org/10.1016/S1084952102001003\">10.1016/S1084952102001003</a>.","ista":"Heisenberg C-PJ, Tada M. 2002. Zebrafish gastrulation movements: bridging cell and developmental biology. Seminars in Cell &#38; Developmental Biology. 13(6), 471–479.","ama":"Heisenberg C-PJ, Tada M. Zebrafish gastrulation movements: bridging cell and developmental biology. <i>Seminars in Cell &#38; Developmental Biology</i>. 2002;13(6):471-479. doi:<a href=\"https://doi.org/10.1016/S1084952102001003\">10.1016/S1084952102001003</a>","chicago":"Heisenberg, Carl-Philipp J, and Masazumi Tada. “Zebrafish Gastrulation Movements: Bridging Cell and Developmental Biology.” <i>Seminars in Cell &#38; Developmental Biology</i>. Academic Press, 2002. <a href=\"https://doi.org/10.1016/S1084952102001003\">https://doi.org/10.1016/S1084952102001003</a>."},"issue":"6","volume":13,"acknowledgement":"We would like to thank Miguel Concha, Will Norton, Tim Geach, Suzanne Eaton, Kimbo Kotovic, Jenny Geiger and Steve Wilson for critical comments on this manuscript, and Lila Solnica-Krezel for providing results prior to publication. C.-P.H. is supported by an Emmy-Noether-Fellowship from the DFG and M.T. by an MRC Career Development Award.","_id":"4196","date_created":"2018-12-11T12:07:31Z","author":[{"first_name":"Carl-Philipp J","last_name":"Heisenberg","id":"39427864-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0912-4566","full_name":"Heisenberg, Carl-Philipp J"},{"last_name":"Tada","first_name":"Masazumi","full_name":"Tada, Masazumi"}],"article_type":"original","date_updated":"2023-06-07T09:28:48Z","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","type":"journal_article","title":"Zebrafish gastrulation movements: bridging cell and developmental biology","publication":"Seminars in Cell & Developmental Biology","abstract":[{"lang":"eng","text":"During vertebrate gastrulation, large cellular rearrangements lead to the formation of the three germ layers, ectoderm, mesoderm and endoderm. Zebrafish offer many genetic and experimental advantages for studying vertebrate gastrulation movements. For instance, several mutants, including silberblick, knypek and trilobite, exhibit defects in morphogenesis during gastrulation. The identification of the genes mutated in these lines together with the analysis of the mutant phenotypes has provided new insights into the molecular and cellular mechanisms that underlie vertebrate gastrulation movements."}],"doi":"10.1016/S1084952102001003","publist_id":"1920","status":"public","extern":"1","oa_version":"None","language":[{"iso":"eng"}],"article_processing_charge":"No","page":"471 - 479","publisher":"Academic Press","quality_controlled":"1","date_published":"2002-12-01T00:00:00Z","publication_status":"published","year":"2002","publication_identifier":{"issn":["1084-9521"]}},{"language":[{"iso":"eng"}],"article_processing_charge":"No","publist_id":"1919","oa_version":"None","extern":"1","status":"public","date_published":"2002-02-19T00:00:00Z","publication_status":"published","year":"2002","publication_identifier":{"issn":["0960-9822"]},"page":"R126 - R128","quality_controlled":"1","publisher":"Cell Press","title":"Wnt signalling: A moving picture emerges from van gogh","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","type":"journal_article","doi":"10.1016/S0960-9822(02)00704-2","publication":"Current Biology","abstract":[{"lang":"eng","text":"Recent studies on vertebrate homologues of the van gogh/strabismus (vang/stbm) gene, a key player in planar cell polarity signalling in Drosophila, show that vang/stbm is involved in patterning and morphogenesis during vertebrate gastrulation where it modulates two distinct Wnt signals."}],"date_created":"2018-12-11T12:07:32Z","_id":"4199","volume":12,"issue":"4","date_updated":"2023-06-07T08:54:35Z","article_type":"original","author":[{"orcid":"0000-0002-0912-4566","full_name":"Heisenberg, Carl-Philipp J","first_name":"Carl-Philipp J","last_name":"Heisenberg","id":"39427864-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Tada, Masazumi","last_name":"Tada","first_name":"Masazumi"}],"pmid":1,"month":"02","intvolume":"        12","day":"19","scopus_import":"1","citation":{"ieee":"C.-P. J. Heisenberg and M. Tada, “Wnt signalling: A moving picture emerges from van gogh,” <i>Current Biology</i>, vol. 12, no. 4. Cell Press, pp. R126–R128, 2002.","ista":"Heisenberg C-PJ, Tada M. 2002. Wnt signalling: A moving picture emerges from van gogh. Current Biology. 12(4), R126–R128.","ama":"Heisenberg C-PJ, Tada M. Wnt signalling: A moving picture emerges from van gogh. <i>Current Biology</i>. 2002;12(4):R126-R128. doi:<a href=\"https://doi.org/10.1016/S0960-9822(02)00704-2\">10.1016/S0960-9822(02)00704-2</a>","chicago":"Heisenberg, Carl-Philipp J, and Masazumi Tada. “Wnt Signalling: A Moving Picture Emerges from van Gogh.” <i>Current Biology</i>. Cell Press, 2002. <a href=\"https://doi.org/10.1016/S0960-9822(02)00704-2\">https://doi.org/10.1016/S0960-9822(02)00704-2</a>.","short":"C.-P.J. Heisenberg, M. Tada, Current Biology 12 (2002) R126–R128.","mla":"Heisenberg, Carl-Philipp J., and Masazumi Tada. “Wnt Signalling: A Moving Picture Emerges from van Gogh.” <i>Current Biology</i>, vol. 12, no. 4, Cell Press, 2002, pp. R126–28, doi:<a href=\"https://doi.org/10.1016/S0960-9822(02)00704-2\">10.1016/S0960-9822(02)00704-2</a>.","apa":"Heisenberg, C.-P. J., &#38; Tada, M. (2002). Wnt signalling: A moving picture emerges from van gogh. <i>Current Biology</i>. Cell Press. <a href=\"https://doi.org/10.1016/S0960-9822(02)00704-2\">https://doi.org/10.1016/S0960-9822(02)00704-2</a>"},"external_id":{"pmid":["11864583"]}}]