[{"year":"2002","pmid":1,"publisher":"Springer Nature","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","_id":"6159","publication":"Nature","oa_version":"None","type":"journal_article","month":"10","day":"31","abstract":[{"text":"Natural Caenorhabditis elegans isolates exhibit either social or solitary feeding on bacteria. We show here that social feeding is induced by nociceptive neurons that detect adverse or stressful conditions. Ablation of the nociceptive neurons ASH and ADL transforms social animals into solitary feeders. Social feeding is probably due to the sensation of noxious chemicals by ASH and ADL neurons; it requires the genes ocr-2 and osm-9, which encode TRP-related transduction channels, and odr-4 and odr-8, which are required to localize sensory chemoreceptors to cilia. Other sensory neurons may suppress social feeding, as social feeding in ocr-2 and odr-4 mutants is restored by mutations in osm-3, a gene required for the development of 26 ciliated sensory neurons. Our data suggest a model for regulation of social feeding by opposing sensory inputs: aversive inputs to nociceptive neurons promote social feeding, whereas antagonistic inputs from neurons that express osm-3 inhibit aggregation.","lang":"eng"}],"date_updated":"2021-01-12T08:06:27Z","page":"899-903","author":[{"last_name":"de Bono","first_name":"Mario","id":"4E3FF80E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8347-0443","full_name":"de Bono, Mario"},{"last_name":"Tobin","first_name":"David M.","full_name":"Tobin, David M."},{"last_name":"Davis","first_name":"M. Wayne","full_name":"Davis, M. Wayne"},{"last_name":"Avery","first_name":"Leon","full_name":"Avery, Leon"},{"first_name":"Cornelia I.","last_name":"Bargmann","full_name":"Bargmann, Cornelia I."}],"date_created":"2019-03-21T10:27:04Z","title":"Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli","volume":419,"status":"public","external_id":{"pmid":["12410303"]},"issue":"6910","language":[{"iso":"eng"}],"citation":{"ama":"de Bono M, Tobin DM, Davis MW, Avery L, Bargmann CI. Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli. <i>Nature</i>. 2002;419(6910):899-903. doi:<a href=\"https://doi.org/10.1038/nature01169\">10.1038/nature01169</a>","apa":"de Bono, M., Tobin, D. M., Davis, M. W., Avery, L., &#38; Bargmann, C. I. (2002). Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/nature01169\">https://doi.org/10.1038/nature01169</a>","ista":"de Bono M, Tobin DM, Davis MW, Avery L, Bargmann CI. 2002. Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli. Nature. 419(6910), 899–903.","mla":"de Bono, Mario, et al. “Social Feeding in Caenorhabditis Elegans Is Induced by Neurons That Detect Aversive Stimuli.” <i>Nature</i>, vol. 419, no. 6910, Springer Nature, 2002, pp. 899–903, doi:<a href=\"https://doi.org/10.1038/nature01169\">10.1038/nature01169</a>.","chicago":"Bono, Mario de, David M. Tobin, M. Wayne Davis, Leon Avery, and Cornelia I. Bargmann. “Social Feeding in Caenorhabditis Elegans Is Induced by Neurons That Detect Aversive Stimuli.” <i>Nature</i>. Springer Nature, 2002. <a href=\"https://doi.org/10.1038/nature01169\">https://doi.org/10.1038/nature01169</a>.","ieee":"M. de Bono, D. M. Tobin, M. W. Davis, L. Avery, and C. I. Bargmann, “Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli,” <i>Nature</i>, vol. 419, no. 6910. Springer Nature, pp. 899–903, 2002.","short":"M. de Bono, D.M. Tobin, M.W. Davis, L. Avery, C.I. Bargmann, Nature 419 (2002) 899–903."},"intvolume":"       419","extern":"1","publication_identifier":{"issn":["0028-0836"]},"publication_status":"published","quality_controlled":"1","date_published":"2002-10-31T00:00:00Z","doi":"10.1038/nature01169"},{"oa":1,"publication_status":"published","date_published":"2002-01-01T00:00:00Z","main_file_link":[{"url":"https://ems.press/journals/dm/articles/8965058","open_access":"1"}],"external_id":{"arxiv":["math/0203096"]},"status":"public","extern":"1","intvolume":"         7","citation":{"ama":"Hausel T, Sturmfels B. Toric hyperkähler varieties. <i>Documenta Mathematica</i>. 2002;7(1):495-534. doi:<a href=\"https://doi.org/10.4171/DM/130\">10.4171/DM/130</a>","ista":"Hausel T, Sturmfels B. 2002. Toric hyperkähler varieties. Documenta Mathematica. 7(1), 495–534.","mla":"Hausel, Tamás, and Bernd Sturmfels. “Toric Hyperkähler Varieties.” <i>Documenta Mathematica</i>, vol. 7, no. 1, Deutsche Mathematiker Vereinigung, 2002, pp. 495–534, doi:<a href=\"https://doi.org/10.4171/DM/130\">10.4171/DM/130</a>.","apa":"Hausel, T., &#38; Sturmfels, B. (2002). Toric hyperkähler varieties. <i>Documenta Mathematica</i>. Deutsche Mathematiker Vereinigung. <a href=\"https://doi.org/10.4171/DM/130\">https://doi.org/10.4171/DM/130</a>","ieee":"T. Hausel and B. Sturmfels, “Toric hyperkähler varieties,” <i>Documenta Mathematica</i>, vol. 7, no. 1. Deutsche Mathematiker Vereinigung, pp. 495–534, 2002.","chicago":"Hausel, Tamás, and Bernd Sturmfels. “Toric Hyperkähler Varieties.” <i>Documenta Mathematica</i>. Deutsche Mathematiker Vereinigung, 2002. <a href=\"https://doi.org/10.4171/DM/130\">https://doi.org/10.4171/DM/130</a>.","short":"T. Hausel, B. Sturmfels, Documenta Mathematica 7 (2002) 495–534."},"page":"495 - 534","date_updated":"2023-07-26T09:16:33Z","abstract":[{"text":"Extending work of Bielawski-Dancer 3 and Konno 14, we develop a theory of toric hyperkähler varieties, which involves toric geometry, matroid theory and convex polyhedra. The framework is a detailed study of semi-projective toric varieties, meaning GIT quotients of affine spaces by torus actions, and specifically, of Lawrence toric varieties, meaning GIT quotients of even-dimensional affine spaces by symplectic torus actions. A toric hyperkähler variety is a complete intersection in a Lawrence toric variety. Both varieties are non-compact, and they share the same cohomology ring, namely, the Stanley-Reisner ring of a matroid modulo a linear system of parameters. Familiar applications of toric geometry to combinatorics, including the Hard Lefschetz Theorem and the volume polynomials of Khovanskii-Pukhlikov 11, are extended to the hyperkähler setting. When the matroid is graphic, our construction gives the toric quiver varieties, in the sense of Nakajima 17.","lang":"eng"}],"oa_version":"Published Version","type":"journal_article","month":"01","volume":7,"date_created":"2018-12-11T11:52:06Z","acknowledgement":"Both authors were supported by the Miller Institute for Basic Research in Science, in the form of a Miller Research Fellowship (1999-2002) for the first author and a Miller Professorship (2000-2001) for the second author. The second author was also supported by the National Science\r\nFoundation (DMS-9970254).","year":"2002","_id":"1451","publication_identifier":{"issn":["1431-0635"]},"doi":"10.4171/DM/130","quality_controlled":"1","language":[{"iso":"eng"}],"issue":"1","author":[{"first_name":"Tamas","last_name":"Hausel","id":"4A0666D8-F248-11E8-B48F-1D18A9856A87","full_name":"Hausel, Tamas"},{"first_name":"Bernd","last_name":"Sturmfels","full_name":"Sturmfels, Bernd"}],"day":"01","title":"Toric hyperkähler varieties","arxiv":1,"publist_id":"5741","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publisher":"Deutsche Mathematiker Vereinigung","publication":"Documenta Mathematica","article_processing_charge":"No","scopus_import":"1","article_type":"original"},{"doi":"10.1074/jbc.m107372200","quality_controlled":"1","publication_identifier":{"issn":["0021-9258"]},"keyword":["Cell Biology","Molecular Biology","Biochemistry"],"issue":"6","language":[{"iso":"eng"}],"title":"ICln Ion channel splice variants in Caenorhabditis elegans","author":[{"last_name":"Fürst","first_name":"Johannes","full_name":"Fürst, Johannes"},{"full_name":"Ritter, Markus","first_name":"Markus","last_name":"Ritter"},{"full_name":"Rudzki, Jakob","last_name":"Rudzki","first_name":"Jakob"},{"first_name":"Johann G","last_name":"Danzl","full_name":"Danzl, Johann G","orcid":"0000-0001-8559-3973","id":"42EFD3B6-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Gschwentner, Martin","last_name":"Gschwentner","first_name":"Martin"},{"full_name":"Scandella, Elke","first_name":"Elke","last_name":"Scandella"},{"first_name":"Martin","last_name":"Jakab","full_name":"Jakab, Martin"},{"full_name":"König, Matthias","first_name":"Matthias","last_name":"König"},{"last_name":"Oehl","first_name":"Bernhard","full_name":"Oehl, Bernhard"},{"full_name":"Lang, Florian","first_name":"Florian","last_name":"Lang"},{"full_name":"Deetjen, Peter","last_name":"Deetjen","first_name":"Peter"},{"full_name":"Paulmichl, Markus","first_name":"Markus","last_name":"Paulmichl"}],"day":"08","file":[{"file_name":"2002_JBC_Fuerst.pdf","success":1,"creator":"alisjak","file_size":798920,"content_type":"application/pdf","relation":"main_file","checksum":"13abe20f78eb37ab62beb006f62c69b7","file_id":"13439","date_updated":"2023-08-01T12:44:09Z","access_level":"open_access","date_created":"2023-08-01T12:44:09Z"}],"publication":"Journal of Biological Chemistry","article_type":"original","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"article_processing_charge":"No","scopus_import":"1","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publisher":"Elsevier","pmid":1,"ddc":["570"],"date_published":"2002-02-08T00:00:00Z","oa":1,"publication_status":"published","has_accepted_license":"1","extern":"1","intvolume":"       277","citation":{"ama":"Fürst J, Ritter M, Rudzki J, et al. ICln Ion channel splice variants in Caenorhabditis elegans. <i>Journal of Biological Chemistry</i>. 2002;277(6):4435-4445. doi:<a href=\"https://doi.org/10.1074/jbc.m107372200\">10.1074/jbc.m107372200</a>","ista":"Fürst J, Ritter M, Rudzki J, Danzl JG, Gschwentner M, Scandella E, Jakab M, König M, Oehl B, Lang F, Deetjen P, Paulmichl M. 2002. ICln Ion channel splice variants in Caenorhabditis elegans. Journal of Biological Chemistry. 277(6), 4435–4445.","mla":"Fürst, Johannes, et al. “ICln Ion Channel Splice Variants in Caenorhabditis Elegans.” <i>Journal of Biological Chemistry</i>, vol. 277, no. 6, Elsevier, 2002, pp. 4435–45, doi:<a href=\"https://doi.org/10.1074/jbc.m107372200\">10.1074/jbc.m107372200</a>.","apa":"Fürst, J., Ritter, M., Rudzki, J., Danzl, J. G., Gschwentner, M., Scandella, E., … Paulmichl, M. (2002). ICln Ion channel splice variants in Caenorhabditis elegans. <i>Journal of Biological Chemistry</i>. Elsevier. <a href=\"https://doi.org/10.1074/jbc.m107372200\">https://doi.org/10.1074/jbc.m107372200</a>","ieee":"J. Fürst <i>et al.</i>, “ICln Ion channel splice variants in Caenorhabditis elegans,” <i>Journal of Biological Chemistry</i>, vol. 277, no. 6. Elsevier, pp. 4435–4445, 2002.","chicago":"Fürst, Johannes, Markus Ritter, Jakob Rudzki, Johann G Danzl, Martin Gschwentner, Elke Scandella, Martin Jakab, et al. “ICln Ion Channel Splice Variants in Caenorhabditis Elegans.” <i>Journal of Biological Chemistry</i>. Elsevier, 2002. <a href=\"https://doi.org/10.1074/jbc.m107372200\">https://doi.org/10.1074/jbc.m107372200</a>.","short":"J. Fürst, M. Ritter, J. Rudzki, J.G. Danzl, M. Gschwentner, E. Scandella, M. Jakab, M. König, B. Oehl, F. Lang, P. Deetjen, M. Paulmichl, Journal of Biological Chemistry 277 (2002) 4435–4445."},"external_id":{"pmid":["11706026"]},"status":"public","volume":277,"date_created":"2023-08-01T12:37:50Z","file_date_updated":"2023-08-01T12:44:09Z","page":"4435-4445","oa_version":"Published Version","month":"02","type":"journal_article","date_updated":"2023-08-01T12:55:54Z","abstract":[{"lang":"eng","text":"ICln is an ion channel identified by expression cloning using a cDNA library from Madin-Darby canine kidney cells. In all organisms tested so far, only one transcript for the ICln protein could be identified. Here we show that two splice variants of the ICln ion channel can be found in Caenorhabditis elegans. Moreover, we show that these two splice variants of the ICln channel protein, which we termed IClnN1 and IClnN2, can be functionally reconstituted and tested in an artificial lipid bilayer. In these experiments, the IClnN1-induced currents showed no voltage-dependent inactivation, whereas the IClnN2-induced currents fully inactivated at positive potentials. The molecular entity responsible for the voltage-dependent inactivation of IClnN2 is a cluster of positively charged amino acids encoded by exon 2a, which is absent in IClnN1. Our experiments suggest a mechanism of channel inactivation that is similar to the “ball and chain” model proposed for the Shaker potassium channel,i.e. a cluster of positively charged amino acids hinders ion permeation through the channel by a molecular and voltage-dependent interaction at the inner vestibulum of the pore. This hypothesis is supported by the finding that synthetic peptides with the same amino acid sequence as the positive cluster can transform the IClnN1-induced current to the current observed after reconstitution of IClnN2. Furthermore, we show that the nematode ICln gene is embedded in an operon harboring two additional genes, which we termed Nx and Ny. Co-reconstitution of Nx and IClnN2 and functional analysis of the related currents revealed a functional interaction between the two proteins, as evidenced by the fact that the IClnN2-induced current in the presence of Nx was no longer voltage-sensitive. The experiments described indicate that the genome organization in nematodes allows an effective approach for the identification of functional partner proteins of ion channels."}],"_id":"13438","acknowledgement":"We are grateful to D. E. Clapham, E. Wöll, G. Meyer, and G. Botta for helpful discussion and/or reading of the manuscript. We also thank T. Stiernagle for providing the N2 strain of C. elegans and A. Wimmer and M. Frick for technical assistance","year":"2002"},{"status":"public","citation":{"ieee":"P. Burlando, F. Pellicciotti, and U. Strasser, “Modelling mountainous water systems between learning and speculating looking for challenges,” <i>Hydrology Research</i>, vol. 33, no. 1. IWA Publishing, pp. 47–74, 2002.","chicago":"Burlando, Paolo, Francesca Pellicciotti, and Ulrich Strasser. “Modelling Mountainous Water Systems between Learning and Speculating Looking for Challenges.” <i>Hydrology Research</i>. IWA Publishing, 2002. <a href=\"https://doi.org/10.2166/nh.2002.0004\">https://doi.org/10.2166/nh.2002.0004</a>.","short":"P. Burlando, F. Pellicciotti, U. Strasser, Hydrology Research 33 (2002) 47–74.","ama":"Burlando P, Pellicciotti F, Strasser U. Modelling mountainous water systems between learning and speculating looking for challenges. <i>Hydrology Research</i>. 2002;33(1):47-74. doi:<a href=\"https://doi.org/10.2166/nh.2002.0004\">10.2166/nh.2002.0004</a>","mla":"Burlando, Paolo, et al. “Modelling Mountainous Water Systems between Learning and Speculating Looking for Challenges.” <i>Hydrology Research</i>, vol. 33, no. 1, IWA Publishing, 2002, pp. 47–74, doi:<a href=\"https://doi.org/10.2166/nh.2002.0004\">10.2166/nh.2002.0004</a>.","ista":"Burlando P, Pellicciotti F, Strasser U. 2002. Modelling mountainous water systems between learning and speculating looking for challenges. Hydrology Research. 33(1), 47–74.","apa":"Burlando, P., Pellicciotti, F., &#38; Strasser, U. (2002). Modelling mountainous water systems between learning and speculating looking for challenges. <i>Hydrology Research</i>. IWA Publishing. <a href=\"https://doi.org/10.2166/nh.2002.0004\">https://doi.org/10.2166/nh.2002.0004</a>"},"intvolume":"        33","extern":"1","publication_status":"published","oa":1,"main_file_link":[{"open_access":"1","url":"https://doi.org/10.2166/nh.2002.0004"}],"date_published":"2002-02-01T00:00:00Z","year":"2002","_id":"12659","date_updated":"2023-02-20T08:30:15Z","abstract":[{"lang":"eng","text":"For many years considerable efforts have been put into investigating and modelling hydrological processes of mountainous catchments. On the one hand, the complexity and intrinsically high variability of the involved processes as well as insufficient knowledge of the underlying physical mechanisms still induce large uncertainties in understanding observed phenomena and predicting the behaviour of the system. On the other hand, the demand for models that are able to simulate mountainous water resource systems is increasing because of the needs related to both water exploitation and water conservation, which clearly call for an integrated vision and modelling of these systems.\r\nAccordingly, this paper moves from a brief survey of the most significant achievements in mountain hydrology to discuss what could be future challenging issues related to the broader spectrum of questions, which hydrologic modelling of mountainous river systems may face in the next decades. Firstly, reference is made to existing methodologies for modelling alpine water systems, focussing on some specific aspects that provide a basis for the discussion of the weaknesses and perspectives of present simulation tools. The future is thus discussed, delineating some of the research challenges that may foster a comprehensive and integrated vision of water related issues in mountainous regions."}],"oa_version":"Published Version","type":"journal_article","month":"02","page":"47-74","date_created":"2023-02-20T08:19:02Z","volume":33,"language":[{"iso":"eng"}],"issue":"1","publication_identifier":{"eissn":["2224-7955"],"issn":["0029-1277"]},"quality_controlled":"1","doi":"10.2166/nh.2002.0004","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"IWA Publishing","scopus_import":"1","article_processing_charge":"No","article_type":"original","publication":"Hydrology Research","day":"01","author":[{"first_name":"Paolo","last_name":"Burlando","full_name":"Burlando, Paolo"},{"full_name":"Pellicciotti, Francesca","id":"b28f055a-81ea-11ed-b70c-a9fe7f7b0e70","first_name":"Francesca","last_name":"Pellicciotti"},{"full_name":"Strasser, Ulrich","first_name":"Ulrich","last_name":"Strasser"}],"title":"Modelling mountainous water systems between learning and speculating looking for challenges"},{"extern":"1","intvolume":"        79","citation":{"short":"D. Mueller, H.L. Janovjak, T. Lehto, L. Kuerschner, K. Anderson, Progress in Biophysics and Molecular Biology 79 (2002) 1–43.","chicago":"Mueller, Daniel, Harald L Janovjak, Tiina Lehto, Lars Kuerschner, and Kurt Anderson. “Observing Structure, Function and Assembly of Single Proteins by AFM.” <i>Progress in Biophysics and Molecular Biology</i>. Elsevier, 2002. <a href=\"https://doi.org/10.1016/S0079-6107(02)00009-3\">https://doi.org/10.1016/S0079-6107(02)00009-3</a>.","ieee":"D. Mueller, H. L. Janovjak, T. Lehto, L. Kuerschner, and K. Anderson, “Observing structure, function and assembly of single proteins by AFM,” <i>Progress in Biophysics and Molecular Biology</i>, vol. 79, no. 1–3. Elsevier, pp. 1–43, 2002.","apa":"Mueller, D., Janovjak, H. L., Lehto, T., Kuerschner, L., &#38; Anderson, K. (2002). Observing structure, function and assembly of single proteins by AFM. <i>Progress in Biophysics and Molecular Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/S0079-6107(02)00009-3\">https://doi.org/10.1016/S0079-6107(02)00009-3</a>","ista":"Mueller D, Janovjak HL, Lehto T, Kuerschner L, Anderson K. 2002. Observing structure, function and assembly of single proteins by AFM. Progress in Biophysics and Molecular Biology. 79(1–3), 1–43.","mla":"Mueller, Daniel, et al. “Observing Structure, Function and Assembly of Single Proteins by AFM.” <i>Progress in Biophysics and Molecular Biology</i>, vol. 79, no. 1–3, Elsevier, 2002, pp. 1–43, doi:<a href=\"https://doi.org/10.1016/S0079-6107(02)00009-3\">10.1016/S0079-6107(02)00009-3</a>.","ama":"Mueller D, Janovjak HL, Lehto T, Kuerschner L, Anderson K. Observing structure, function and assembly of single proteins by AFM. <i>Progress in Biophysics and Molecular Biology</i>. 2002;79(1-3):1-43. doi:<a href=\"https://doi.org/10.1016/S0079-6107(02)00009-3\">10.1016/S0079-6107(02)00009-3</a>"},"status":"public","external_id":{"pmid":["12225775"]},"date_published":"2002-05-01T00:00:00Z","publication_status":"published","_id":"3421","year":"2002","volume":79,"date_created":"2018-12-11T12:03:14Z","page":"1 - 43","month":"05","type":"journal_article","oa_version":"None","abstract":[{"text":"Single molecule experiments provide insight into the individuality of biological macromolecules, their unique function, reaction pathways, trajectories and molecular interactions. The exceptional signal-to-noise ratio of the atomic force microscope allows individual proteins to be imaged under physiologically relevant conditions at a lateral resolution of 0.5–1 nm and a vertical resolution of 0.1–0.2 nm. Recently, it has become possible to observe single molecule events using this technique. This capability is reviewed on various water-soluble and membrane proteins. Examples of the observation of function, variability, and assembly of single proteins are discussed. Statistical analysis is important to extend conclusions derived from single molecule experiments to protein species. Such approaches allow the classification of protein conformations and movements. Recent developments of probe microscopy techniques allow simultaneous measurement of multiple signals on individual macromolecules, and greatly extend the range of experiments possible for probing biological systems at the molecular level. Biologists exploring molecular mechanisms will benefit from a burgeoning of scanning probe microscopes and of their future combination with molecular biological experiments.","lang":"eng"}],"date_updated":"2023-07-17T11:36:32Z","issue":"1-3","language":[{"iso":"eng"}],"doi":"10.1016/S0079-6107(02)00009-3","quality_controlled":"1","publication_identifier":{"issn":["0079-6107"]},"publication":"Progress in Biophysics and Molecular Biology","article_type":"review","article_processing_charge":"No","scopus_import":"1","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publisher":"Elsevier","pmid":1,"title":"Observing structure, function and assembly of single proteins by AFM","publist_id":"2980","author":[{"full_name":"Mueller, Daniel","last_name":"Mueller","first_name":"Daniel"},{"first_name":"Harald L","last_name":"Janovjak","full_name":"Janovjak, Harald L","id":"33BA6C30-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8023-9315"},{"first_name":"Tiina","last_name":"Lehto","full_name":"Lehto, Tiina"},{"full_name":"Kuerschner, Lars","last_name":"Kuerschner","first_name":"Lars"},{"full_name":"Anderson, Kurt","first_name":"Kurt","last_name":"Anderson"}],"day":"01"},{"status":"public","external_id":{"pmid":["12074169"]},"citation":{"short":"P. Müller, H.L. Janovjak, A. Miserez, Z. Dobbie, Biotechniques 32 (2002) 1372–1379.","chicago":"Müller, Patrick, Harald L Janovjak, Andre Miserez, and Zuzana Dobbie. “Processing of Gene Expression Data Generated by Quantitative Real-Time RT-PCR.” <i>Biotechniques</i>. Informa Healthcare, 2002.","ieee":"P. Müller, H. L. Janovjak, A. Miserez, and Z. Dobbie, “Processing of gene expression data generated by quantitative real-time RT-PCR,” <i>Biotechniques</i>, vol. 32, no. 6. Informa Healthcare, pp. 1372–1379, 2002.","apa":"Müller, P., Janovjak, H. L., Miserez, A., &#38; Dobbie, Z. (2002). Processing of gene expression data generated by quantitative real-time RT-PCR. <i>Biotechniques</i>. Informa Healthcare.","ista":"Müller P, Janovjak HL, Miserez A, Dobbie Z. 2002. Processing of gene expression data generated by quantitative real-time RT-PCR. Biotechniques. 32(6), 1372–1379.","mla":"Müller, Patrick, et al. “Processing of Gene Expression Data Generated by Quantitative Real-Time RT-PCR.” <i>Biotechniques</i>, vol. 32, no. 6, Informa Healthcare, 2002, pp. 1372–79.","ama":"Müller P, Janovjak HL, Miserez A, Dobbie Z. Processing of gene expression data generated by quantitative real-time RT-PCR. <i>Biotechniques</i>. 2002;32(6):1372-1379."},"extern":"1","intvolume":"        32","publication_status":"published","date_published":"2002-06-01T00:00:00Z","year":"2002","_id":"3422","date_updated":"2023-07-17T11:29:06Z","abstract":[{"text":"Quantitative real-time PCR represents a highly sensitive and powerful technique for the quantitation of nucleic acids. It has a tremendous potential for the high-throughput analysis of gene expression in research and routine diagnostics. However, the major hurdle is not the practical performance of the experiments themselves but rather the efficient evaluation and the mathematical and statistical analysis of the enormous amount of data gained by this technology, as these functions are not included in the software provided by the manufacturers of the detection systems. In this work, we focus on the mathematical evaluation and analysis of the data generated by quantitative real-time PCR, the calculation of the final results, the propagation of experimental variation of the measured values to the final results, and the statistical analysis. We developed a Microsoft Excel-based software application coded in Visual Basic for Applications, called Q-Gene, which addresses these points. Q-Gene manages and expedites the planning, performance, and evaluation of quantitative real-time PCR experiments, as well as the mathematical and statistical analysis, storage, and graphical presentation of the data. The Q-Gene software application is a tool to cope with complex quantitative real-time PCR experiments at a high-throughput scale and considerably expedites and rationalizes the experimental setup, data analysis, and data management while ensuring highest reproducibility.","lang":"eng"}],"type":"journal_article","oa_version":"None","month":"06","page":"1372 - 1379","date_created":"2018-12-11T12:03:15Z","volume":32,"language":[{"iso":"eng"}],"issue":"6","publication_identifier":{"issn":["0736-6205"]},"quality_controlled":"1","pmid":1,"publisher":"Informa Healthcare","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","scopus_import":"1","article_processing_charge":"No","article_type":"original","publication":"Biotechniques","day":"01","author":[{"full_name":"Müller, Patrick","last_name":"Müller","first_name":"Patrick"},{"id":"33BA6C30-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8023-9315","full_name":"Janovjak, Harald L","first_name":"Harald L","last_name":"Janovjak"},{"full_name":"Miserez, Andre","first_name":"Andre","last_name":"Miserez"},{"first_name":"Zuzana","last_name":"Dobbie","full_name":"Dobbie, Zuzana"}],"publist_id":"2979","title":"Processing of gene expression data generated by quantitative real-time RT-PCR"},{"date_published":"2002-01-01T00:00:00Z","publication_status":"published","extern":"1","conference":{"end_date":"2002-01-22","start_date":"2002-01-20","name":"Winter Workshop on Nuclear Dynamics","location":"Nassau, Bahamas"},"language":[{"iso":"eng"}],"citation":{"short":"W. Bauer, M.T. Bollenbach, M. Kleine Berkenbusch, H. Harreis, in:, Proceedings of the 18th Winter Workshop on Nuclear Dynamics, EP Systema, 2002, pp. 111–118.","ieee":"W. Bauer, M. T. Bollenbach, M. Kleine Berkenbusch, and H. Harreis, “The percolation interpretation of the nuclear fragmentation phase transition,” in <i>Proceedings of the 18th Winter Workshop on Nuclear Dynamics</i>, Nassau, Bahamas, 2002, pp. 111–118.","chicago":"Bauer, Wolfgang, Mark Tobias Bollenbach, Marko Kleine Berkenbusch, and Holger Harreis. “The Percolation Interpretation of the Nuclear Fragmentation Phase Transition.” In <i>Proceedings of the 18th Winter Workshop on Nuclear Dynamics</i>, 111–18. EP Systema, 2002.","ista":"Bauer W, Bollenbach MT, Kleine Berkenbusch M, Harreis H. 2002. The percolation interpretation of the nuclear fragmentation phase transition. Proceedings of the 18th Winter Workshop on Nuclear Dynamics. Winter Workshop on Nuclear Dynamics, 111–118.","mla":"Bauer, Wolfgang, et al. “The Percolation Interpretation of the Nuclear Fragmentation Phase Transition.” <i>Proceedings of the 18th Winter Workshop on Nuclear Dynamics</i>, EP Systema, 2002, pp. 111–18.","apa":"Bauer, W., Bollenbach, M. T., Kleine Berkenbusch, M., &#38; Harreis, H. (2002). The percolation interpretation of the nuclear fragmentation phase transition. In <i>Proceedings of the 18th Winter Workshop on Nuclear Dynamics</i> (pp. 111–118). Nassau, Bahamas: EP Systema.","ama":"Bauer W, Bollenbach MT, Kleine Berkenbusch M, Harreis H. The percolation interpretation of the nuclear fragmentation phase transition. In: <i>Proceedings of the 18th Winter Workshop on Nuclear Dynamics</i>. EP Systema; 2002:111-118."},"status":"public","title":"The percolation interpretation of the nuclear fragmentation phase transition","date_created":"2018-12-11T12:03:15Z","publist_id":"2978","author":[{"full_name":"Bauer, Wolfgang","first_name":"Wolfgang","last_name":"Bauer"},{"last_name":"Bollenbach","first_name":"Mark Tobias","full_name":"Bollenbach, Mark Tobias","orcid":"0000-0003-4398-476X","id":"3E6DB97A-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Kleine Berkenbusch, Marko","first_name":"Marko","last_name":"Kleine Berkenbusch"},{"full_name":"Harreis, Holger","first_name":"Holger","last_name":"Harreis"}],"page":"111 - 118","date_updated":"2023-07-17T11:15:14Z","day":"01","type":"conference","oa_version":"None","month":"01","publication":"Proceedings of the 18th Winter Workshop on Nuclear Dynamics","_id":"3423","article_processing_charge":"No","publisher":"EP Systema","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","year":"2002"},{"publication_status":"published","publication_identifier":{"isbn":["9781510832008"]},"doi":"10.1063/1.1523196 ","date_published":"2002-11-26T00:00:00Z","quality_controlled":"1","alternative_title":["Exotic Clustering, American Institute of Physics Conference Proceedings"],"status":"public","intvolume":"       644","extern":"1","conference":{"start_date":"2002-06-10","location":"Catania, Italy","name":"CRIS: Catania Relativistic Ion Studies ","end_date":"2002-06-14"},"language":[{"iso":"eng"}],"citation":{"short":"M.T. Bollenbach, W. Bauer, in:, American Institute of Physics, 2002, pp. 219–232.","ieee":"M. T. Bollenbach and W. Bauer, “3d supernovae collapse calculations,” presented at the CRIS: Catania Relativistic Ion Studies , Catania, Italy, 2002, vol. 644, pp. 219–232.","chicago":"Bollenbach, Mark Tobias, and Wolfgang Bauer. “3d Supernovae Collapse Calculations,” 644:219–32. American Institute of Physics, 2002. <a href=\"https://doi.org/10.1063/1.1523196 \">https://doi.org/10.1063/1.1523196 </a>.","mla":"Bollenbach, Mark Tobias, and Wolfgang Bauer. <i>3d Supernovae Collapse Calculations</i>. Vol. 644, American Institute of Physics, 2002, pp. 219–32, doi:<a href=\"https://doi.org/10.1063/1.1523196 \">10.1063/1.1523196 </a>.","ista":"Bollenbach MT, Bauer W. 2002. 3d supernovae collapse calculations. CRIS: Catania Relativistic Ion Studies , Exotic Clustering, American Institute of Physics Conference Proceedings, vol. 644, 219–232.","apa":"Bollenbach, M. T., &#38; Bauer, W. (2002). 3d supernovae collapse calculations (Vol. 644, pp. 219–232). Presented at the CRIS: Catania Relativistic Ion Studies , Catania, Italy: American Institute of Physics. <a href=\"https://doi.org/10.1063/1.1523196 \">https://doi.org/10.1063/1.1523196 </a>","ama":"Bollenbach MT, Bauer W. 3d supernovae collapse calculations. In: Vol 644. American Institute of Physics; 2002:219-232. doi:<a href=\"https://doi.org/10.1063/1.1523196 \">10.1063/1.1523196 </a>"},"author":[{"last_name":"Bollenbach","first_name":"Mark Tobias","full_name":"Bollenbach, Mark Tobias","id":"3E6DB97A-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-4398-476X"},{"last_name":"Bauer","first_name":"Wolfgang","full_name":"Bauer, Wolfgang"}],"page":"219 - 232","day":"26","abstract":[{"text":"We give a brief overview of the current understanding of the explosion mechanism of core collapse supernovae. Our main focus is the impact of rotation on the explosion. Recent observations of the polarization of the light emitted by supernova explosions indicate that there are large deviations from spherical symmetry in the very heart of the explosion the origin of which is unknown. We use the new approach of a three dimensional test particle based simulation to simulate the infall phase of a supernova event. The underlying microphysics is simplified to make this computationally possible. A systematic study of the influence of rotation mainly during the infall phase of the collapse of a typical iron core is performed. Indications for significant deviations from spherical symmetry are found in our very rapidly rotating models. © 2002 American Institute of Physics\r\n","lang":"eng"}],"date_updated":"2023-07-17T11:05:27Z","month":"11","oa_version":"None","type":"conference","title":"3d supernovae collapse calculations","volume":644,"date_created":"2018-12-11T12:03:15Z","publist_id":"2977","publisher":"American Institute of Physics","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","year":"2002","_id":"3424","article_processing_charge":"No"},{"date_published":"2002-01-15T00:00:00Z","quality_controlled":0,"publication_status":"published","extern":1,"conference":{"name":"IT-Built: Information Technology For Built Environment"},"citation":{"chicago":"Mallick, Sanhita, Krishnendu Chatterjee, Arif Merchant, and Pallab Dasgupta. “Implementation of Shape Grammar for Plan Analysis.” Elsevier, 2002.","ieee":"S. Mallick, K. Chatterjee, A. Merchant, and P. Dasgupta, “Implementation of shape grammar for plan analysis,” presented at the IT-Built: Information Technology For Built Environment, 2002.","short":"S. Mallick, K. Chatterjee, A. Merchant, P. Dasgupta, in:, Elsevier, 2002.","ama":"Mallick S, Chatterjee K, Merchant A, Dasgupta P. Implementation of shape grammar for plan analysis. In: Elsevier; 2002.","apa":"Mallick, S., Chatterjee, K., Merchant, A., &#38; Dasgupta, P. (2002). Implementation of shape grammar for plan analysis. Presented at the IT-Built: Information Technology For Built Environment, Elsevier.","ista":"Mallick S, Chatterjee K, Merchant A, Dasgupta P. 2002. Implementation of shape grammar for plan analysis. IT-Built: Information Technology For Built Environment.","mla":"Mallick, Sanhita, et al. <i>Implementation of Shape Grammar for Plan Analysis</i>. Elsevier, 2002."},"status":"public","title":"Implementation of shape grammar for plan analysis","date_created":"2018-12-11T12:03:23Z","publist_id":"2939","author":[{"full_name":"Mallick, Sanhita","last_name":"Mallick","first_name":"Sanhita"},{"id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4561-241X","full_name":"Krishnendu Chatterjee","first_name":"Krishnendu","last_name":"Chatterjee"},{"full_name":"Merchant, Arif N","first_name":"Arif","last_name":"Merchant"},{"full_name":"Dasgupta, Pallab","first_name":"Pallab","last_name":"Dasgupta"}],"day":"15","date_updated":"2021-01-12T07:43:31Z","month":"01","type":"conference","_id":"3448","publisher":"Elsevier","year":"2002"},{"title":"Patch-clamp recording in brain slices with improved slicer technology","publist_id":"2890","author":[{"first_name":"Jörg","last_name":"Geiger","full_name":"Geiger, Jörg"},{"first_name":"Joseph","last_name":"Bischofberger","full_name":"Bischofberger, Joseph"},{"first_name":"Imre","last_name":"Vida","full_name":"Vida, Imre"},{"last_name":"Fröbe","first_name":"Ulrich","full_name":"Fröbe, Ulrich"},{"full_name":"Pfitzinger, S","first_name":"S","last_name":"Pfitzinger"},{"full_name":"Weber, H.","last_name":"Weber","first_name":"H."},{"last_name":"Haverkampf","first_name":"Klaus","full_name":"Haverkampf, Klaus"},{"full_name":"Jonas, Peter M","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5001-4804","last_name":"Jonas","first_name":"Peter M"}],"day":"01","publication":"Pflugers Archiv : European Journal of Physiology","article_type":"original","article_processing_charge":"No","scopus_import":"1","publisher":"Springer","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","pmid":1,"doi":"10.1007/s00424-001-0735-3","quality_controlled":"1","publication_identifier":{"issn":["0031-6768"]},"issue":"3","language":[{"iso":"eng"}],"volume":443,"date_created":"2018-12-11T12:03:38Z","page":"491 - 501","oa_version":"None","month":"01","type":"journal_article","abstract":[{"text":"The use of advanced patch-clamp recording techniques in brain slices, such as simultaneous recording from multiple neurons and recording from dendrites or presynaptic terminals, demands slices of the highest quality. In this context the mechanics of the tissue slicer are an important factor. Ideally, a tissue slicer should generate large-amplitude and high-frequency movements of the cutting blade in a horizontal axis, with minimal vibrations in the vertical axis. We developed a vibroslicer that fulfils these in part conflicting requirements. The oscillator is a permanent-magnet-coil-leaf-spring system. Using an auto-resonant mechano-electrical feedback circuit, large horizontal oscillations (up to 3 mm peak-to-peak) with high frequency (,90 Hz) are generated. To minimize vertical vibrations, an adjustment mechanism was employed that allowed alignment of the cutting edge of the blade with the major axis of the oscillation. A vibroprobe device was used to monitor vertical vibrations during adjustment. The system is based on the shading of the light path between a light-emitting diode (LED) and a photodiode. Vibroprobe monitoring revealed that the vibroslicer, after appropriate adjustment, generated vertical vibrations of &lt;1 µm, significantly less than many commercial tissue slicers. Light- and electron-microscopic analysis of surface layers of slices cut with the vibroslicer showed that cellular elements, dendritic processes and presynaptic terminals are well preserved under these conditions, as required for patch-clamp recording from these structures.","lang":"eng"}],"date_updated":"2023-07-17T07:36:37Z","_id":"3497","acknowledgement":"We thank Dr. M. Frotscher for reading the manuscript, and H. Kressner, R. Laufersweiler, and A. Bühler for help with the construction of several prototypes of vibroslicer and vibroprobe. We also thank A. Blomenkamp, K. Winterhalter, B. Joch, and A. Schneider for technical assistance. This work was supported by grants of the Deutsche Forschungsgemeinschaft\r\n(SFB 505/C5, C6) and the Human Frontiers Science Program Organization (RG0017/1998-B).","year":"2002","date_published":"2002-01-01T00:00:00Z","publication_status":"published","extern":"1","intvolume":"       443","citation":{"ista":"Geiger J, Bischofberger J, Vida I, Fröbe U, Pfitzinger S, Weber H, Haverkampf K, Jonas PM. 2002. Patch-clamp recording in brain slices with improved slicer technology. Pflugers Archiv : European Journal of Physiology. 443(3), 491–501.","mla":"Geiger, Jörg, et al. “Patch-Clamp Recording in Brain Slices with Improved Slicer Technology.” <i>Pflugers Archiv : European Journal of Physiology</i>, vol. 443, no. 3, Springer, 2002, pp. 491–501, doi:<a href=\"https://doi.org/10.1007/s00424-001-0735-3\">10.1007/s00424-001-0735-3</a>.","apa":"Geiger, J., Bischofberger, J., Vida, I., Fröbe, U., Pfitzinger, S., Weber, H., … Jonas, P. M. (2002). Patch-clamp recording in brain slices with improved slicer technology. <i>Pflugers Archiv : European Journal of Physiology</i>. Springer. <a href=\"https://doi.org/10.1007/s00424-001-0735-3\">https://doi.org/10.1007/s00424-001-0735-3</a>","ama":"Geiger J, Bischofberger J, Vida I, et al. Patch-clamp recording in brain slices with improved slicer technology. <i>Pflugers Archiv : European Journal of Physiology</i>. 2002;443(3):491-501. doi:<a href=\"https://doi.org/10.1007/s00424-001-0735-3\">10.1007/s00424-001-0735-3</a>","short":"J. Geiger, J. Bischofberger, I. Vida, U. Fröbe, S. Pfitzinger, H. Weber, K. Haverkampf, P.M. Jonas, Pflugers Archiv : European Journal of Physiology 443 (2002) 491–501.","ieee":"J. Geiger <i>et al.</i>, “Patch-clamp recording in brain slices with improved slicer technology,” <i>Pflugers Archiv : European Journal of Physiology</i>, vol. 443, no. 3. Springer, pp. 491–501, 2002.","chicago":"Geiger, Jörg, Joseph Bischofberger, Imre Vida, Ulrich Fröbe, S Pfitzinger, H. Weber, Klaus Haverkampf, and Peter M Jonas. “Patch-Clamp Recording in Brain Slices with Improved Slicer Technology.” <i>Pflugers Archiv : European Journal of Physiology</i>. Springer, 2002. <a href=\"https://doi.org/10.1007/s00424-001-0735-3\">https://doi.org/10.1007/s00424-001-0735-3</a>."},"external_id":{"pmid":["11810221"]},"status":"public"},{"date_created":"2018-12-11T12:03:42Z","publist_id":"2879","title":"Methods of generating three-dimensional digital models of objects by wrapping point cloud data points","date_updated":"2022-01-05T14:09:36Z","abstract":[{"lang":"eng","text":"A method of automatic conversion of a physical object into a three-dimensional digital model. The method acquires a set of measured data points on the surface of a physical model. From the measured data points, the method reconstructs a digital model of the physical object using a Delaunay complex of the points, a flow strcuture of the simplicies in the Delaunay complex and retracting the Delaunay complex into a digital model of the physical object using the flow structure. The method then outputs the digital model of the physical object."}],"day":"23","oa_version":"Published Version","type":"patent","month":"04","author":[{"first_name":"Herbert","last_name":"Edelsbrunner","orcid":"0000-0002-9823-6833","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","full_name":"Edelsbrunner, Herbert"},{"last_name":"Fu","first_name":"Ping","full_name":"Fu, Ping"}],"article_processing_charge":"No","applicant":["Raindrop Geomagic, Inc."],"_id":"3508","year":"2002","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","main_file_link":[{"url":"https://patents.google.com/patent/US6377865B1","open_access":"1"}],"date_published":"2002-04-23T00:00:00Z","publication_date":"2002-04-23","oa":1,"citation":{"ama":"Edelsbrunner H, Fu P. Methods of generating three-dimensional digital models of objects by wrapping point cloud data points. 2002.","mla":"Edelsbrunner, Herbert, and Ping Fu. <i>Methods of Generating Three-Dimensional Digital Models of Objects by Wrapping Point Cloud Data Points</i>. 2002.","ista":"Edelsbrunner H, Fu P. 2002. Methods of generating three-dimensional digital models of objects by wrapping point cloud data points.","apa":"Edelsbrunner, H., &#38; Fu, P. (2002). Methods of generating three-dimensional digital models of objects by wrapping point cloud data points.","ieee":"H. Edelsbrunner and P. Fu, “Methods of generating three-dimensional digital models of objects by wrapping point cloud data points.” 2002.","chicago":"Edelsbrunner, Herbert, and Ping Fu. “Methods of Generating Three-Dimensional Digital Models of Objects by Wrapping Point Cloud Data Points,” 2002.","short":"H. Edelsbrunner, P. Fu, (2002)."},"extern":"1","ipn":"US6377865B1","ipc":"G16Z99/00 ; G06K9/28 ; G06T17/10 ; G06T17/20","status":"public"},{"day":"01","author":[{"last_name":"Buzsáki","first_name":"György","full_name":"Buzsáki, György"},{"id":"3FA14672-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-5193-4036","full_name":"Csicsvari, Jozsef L","last_name":"Csicsvari","first_name":"Jozsef L"},{"full_name":"Dragoi, George","first_name":"George","last_name":"Dragoi"},{"full_name":"Harris, Kenneth","first_name":"Kenneth","last_name":"Harris"},{"last_name":"Henze","first_name":"D.","full_name":"Henze, D."},{"last_name":"Hirase","first_name":"Hajima","full_name":"Hirase, Hajima"}],"publist_id":"2851","title":"Homeostatic maintenance of neuronal excitability by burst discharges in vivo","pmid":1,"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publisher":"Oxford University Press","article_processing_charge":"No","scopus_import":"1","article_type":"original","publication":"Cerebral Cortex","publication_identifier":{"issn":["1047-3211"]},"quality_controlled":"1","doi":"10.1093/cercor/12.9.893","language":[{"iso":"eng"}],"issue":"9","date_updated":"2023-07-17T07:27:12Z","abstract":[{"lang":"eng","text":"Information in neuronal networks is thought to be represented by the rate of discharge and the temporal relationship between the discharging neurons. The discharge frequency of neurons is affected by their afferents and intrinsic properties, and shows great individual variability. The temporal coordination of neurons is greatly facilitated by network oscillations. In the hippocampus, population synchrony fluctuates during theta and gamma oscillations (10-100 ms scale) and can increase almost 10-fold during sharp wave bursts. Despite these large changes in excitability in the sub-second scale, longer-term (minute-scale) firing rates of individual neurons are relatively constant in an unchanging environment. As a result, mean hippocampal output remains stable over time. To understand the mechanisms responsible for this homeostasis, we address the following issues: (i) Can firing rates of single cells be modified? (ii) Once modified, what mechanism(s) can maintain the changes? We show that firing rates of hippocampal pyramidal cells can be altered in a novel environment and by Hebbian pairing of physiological input patterns with postsynaptic burst discharge. We also illustrate a competition between single spikes and the occurrence of spike bursts. Since spike-inducing (suprathreshold) inputs decrease the ability of strong ('teaching') inputs to induce a burst discharge, we propose that the single spike versus burst competition presents a homeostatic regulatory mechanism to maintain synaptic strength and, consequently, firing rate in pyramidal cells."}],"month":"09","oa_version":"None","type":"journal_article","page":"893 - 899","date_created":"2018-12-11T12:03:50Z","volume":12,"year":"2002","_id":"3533","publication_status":"published","date_published":"2002-09-01T00:00:00Z","status":"public","external_id":{"pmid":["12183388"]},"citation":{"ieee":"G. Buzsáki, J. L. Csicsvari, G. Dragoi, K. Harris, D. Henze, and H. Hirase, “Homeostatic maintenance of neuronal excitability by burst discharges in vivo,” <i>Cerebral Cortex</i>, vol. 12, no. 9. Oxford University Press, pp. 893–899, 2002.","chicago":"Buzsáki, György, Jozsef L Csicsvari, George Dragoi, Kenneth Harris, D. Henze, and Hajima Hirase. “Homeostatic Maintenance of Neuronal Excitability by Burst Discharges in Vivo.” <i>Cerebral Cortex</i>. Oxford University Press, 2002. <a href=\"https://doi.org/10.1093/cercor/12.9.893\">https://doi.org/10.1093/cercor/12.9.893</a>.","short":"G. Buzsáki, J.L. Csicsvari, G. Dragoi, K. Harris, D. Henze, H. Hirase, Cerebral Cortex 12 (2002) 893–899.","ama":"Buzsáki G, Csicsvari JL, Dragoi G, Harris K, Henze D, Hirase H. Homeostatic maintenance of neuronal excitability by burst discharges in vivo. <i>Cerebral Cortex</i>. 2002;12(9):893-899. doi:<a href=\"https://doi.org/10.1093/cercor/12.9.893\">10.1093/cercor/12.9.893</a>","mla":"Buzsáki, György, et al. “Homeostatic Maintenance of Neuronal Excitability by Burst Discharges in Vivo.” <i>Cerebral Cortex</i>, vol. 12, no. 9, Oxford University Press, 2002, pp. 893–99, doi:<a href=\"https://doi.org/10.1093/cercor/12.9.893\">10.1093/cercor/12.9.893</a>.","ista":"Buzsáki G, Csicsvari JL, Dragoi G, Harris K, Henze D, Hirase H. 2002. Homeostatic maintenance of neuronal excitability by burst discharges in vivo. Cerebral Cortex. 12(9), 893–899.","apa":"Buzsáki, G., Csicsvari, J. L., Dragoi, G., Harris, K., Henze, D., &#38; Hirase, H. (2002). Homeostatic maintenance of neuronal excitability by burst discharges in vivo. <i>Cerebral Cortex</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/cercor/12.9.893\">https://doi.org/10.1093/cercor/12.9.893</a>"},"intvolume":"        12","extern":"1"},{"quality_controlled":"1","doi":"10.1093/genetics/161.4.1727","publication_identifier":{"issn":["0016-6731"]},"language":[{"iso":"eng"}],"issue":"4","publist_id":"2762","title":"General models of multilocus evolution","day":"01","author":[{"full_name":"Kirkpatrick, Mark","first_name":"Mark","last_name":"Kirkpatrick"},{"full_name":"Johnson, Toby","last_name":"Johnson","first_name":"Toby"},{"last_name":"Barton","first_name":"Nicholas H","orcid":"0000-0002-8548-5240","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","full_name":"Barton, Nicholas H"}],"article_processing_charge":"No","scopus_import":"1","article_type":"original","publication":"Genetics","pmid":1,"publisher":"Genetics Society of America","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1462196/"}],"date_published":"2002-08-01T00:00:00Z","oa":1,"publication_status":"published","citation":{"short":"M. Kirkpatrick, T. Johnson, N.H. Barton, Genetics 161 (2002) 1727–1750.","chicago":"Kirkpatrick, Mark, Toby Johnson, and Nicholas H Barton. “General Models of Multilocus Evolution.” <i>Genetics</i>. Genetics Society of America, 2002. <a href=\"https://doi.org/10.1093/genetics/161.4.1727\">https://doi.org/10.1093/genetics/161.4.1727</a>.","ieee":"M. Kirkpatrick, T. Johnson, and N. H. Barton, “General models of multilocus evolution,” <i>Genetics</i>, vol. 161, no. 4. Genetics Society of America, pp. 1727–1750, 2002.","apa":"Kirkpatrick, M., Johnson, T., &#38; Barton, N. H. (2002). General models of multilocus evolution. <i>Genetics</i>. Genetics Society of America. <a href=\"https://doi.org/10.1093/genetics/161.4.1727\">https://doi.org/10.1093/genetics/161.4.1727</a>","mla":"Kirkpatrick, Mark, et al. “General Models of Multilocus Evolution.” <i>Genetics</i>, vol. 161, no. 4, Genetics Society of America, 2002, pp. 1727–50, doi:<a href=\"https://doi.org/10.1093/genetics/161.4.1727\">10.1093/genetics/161.4.1727</a>.","ista":"Kirkpatrick M, Johnson T, Barton NH. 2002. General models of multilocus evolution. Genetics. 161(4), 1727–1750.","ama":"Kirkpatrick M, Johnson T, Barton NH. General models of multilocus evolution. <i>Genetics</i>. 2002;161(4):1727-1750. doi:<a href=\"https://doi.org/10.1093/genetics/161.4.1727\">10.1093/genetics/161.4.1727</a>"},"extern":"1","intvolume":"       161","status":"public","external_id":{"pmid":["12196414"]},"date_created":"2018-12-11T12:04:17Z","volume":161,"date_updated":"2023-07-11T13:20:26Z","abstract":[{"text":"In 1991, Barton and Turelli developed recursions to describe the evolution of multilocus systems under arbitrary forms of selection. This article generalizes their approach to allow for arbitrary modes of inheritance, including diploidy, polyploidy, sex linkage, cytoplasmic inheritance, and genomic imprinting. The framework is also extended to allow for other deterministic evolutionary forces, including migration and mutation. Exact recursions that fully describe the state of the population are presented; these are implemented in a computer algebra package (available on the Web at http://helios.bto.ed.ac.uk/evolgen). Despite the generality of our framework, it can describe evolutionary dynamics exactly by just two equations. These recursions can be further simplified using a &quot;quasi-linkage equilibrium&quot; (QLE) approximation. We illustrate the methods by finding the effect of natural selection, sexual selection, mutation, and migration on the genetic composition of a population.","lang":"eng"}],"oa_version":"Published Version","month":"08","type":"journal_article","page":"1727 - 1750","_id":"3621","year":"2002"},{"issue":"5572","language":[{"iso":"eng"}],"publication_identifier":{"issn":["0036-8075"]},"doi":"10.1126/science.1067407","quality_controlled":"1","publisher":"American Association for the Advancement of Science","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","pmid":1,"publication":"Science","article_type":"original","scopus_import":"1","article_processing_charge":"No","author":[{"id":"47F8433E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6220-2052","full_name":"Guet, Calin C","first_name":"Calin C","last_name":"Guet"},{"first_name":"Michael","last_name":"Elowitz","full_name":"Elowitz, Michael"},{"full_name":"Hsing, Weihong","last_name":"Hsing","first_name":"Weihong"},{"full_name":"Leibler, Stanislas","first_name":"Stanislas","last_name":"Leibler"}],"day":"24","title":"Combinatorial synthesis of genetic networks","publist_id":"2471","external_id":{"pmid":["12029133"]},"status":"public","extern":"1","intvolume":"       296","citation":{"ama":"Guet CC, Elowitz M, Hsing W, Leibler S. Combinatorial synthesis of genetic networks. <i>Science</i>. 2002;296(5572):1466-1470. doi:<a href=\"https://doi.org/10.1126/science.1067407\">10.1126/science.1067407</a>","ista":"Guet CC, Elowitz M, Hsing W, Leibler S. 2002. Combinatorial synthesis of genetic networks. Science. 296(5572), 1466–1470.","mla":"Guet, Calin C., et al. “Combinatorial Synthesis of Genetic Networks.” <i>Science</i>, vol. 296, no. 5572, American Association for the Advancement of Science, 2002, pp. 1466–70, doi:<a href=\"https://doi.org/10.1126/science.1067407\">10.1126/science.1067407</a>.","apa":"Guet, C. C., Elowitz, M., Hsing, W., &#38; Leibler, S. (2002). Combinatorial synthesis of genetic networks. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1067407\">https://doi.org/10.1126/science.1067407</a>","ieee":"C. C. Guet, M. Elowitz, W. Hsing, and S. Leibler, “Combinatorial synthesis of genetic networks,” <i>Science</i>, vol. 296, no. 5572. American Association for the Advancement of Science, pp. 1466–1470, 2002.","chicago":"Guet, Calin C, Michael Elowitz, Weihong Hsing, and Stanislas Leibler. “Combinatorial Synthesis of Genetic Networks.” <i>Science</i>. American Association for the Advancement of Science, 2002. <a href=\"https://doi.org/10.1126/science.1067407\">https://doi.org/10.1126/science.1067407</a>.","short":"C.C. Guet, M. Elowitz, W. Hsing, S. Leibler, Science 296 (2002) 1466–1470."},"publication_status":"published","date_published":"2002-05-24T00:00:00Z","year":"2002","_id":"3757","page":"1466 - 1470","type":"journal_article","oa_version":"None","month":"05","date_updated":"2023-07-11T12:48:53Z","abstract":[{"lang":"eng","text":"A central problem in biology is determining how genes interact as parts of functional networks. Creation and analysis of synthetic networks, composed of well-characterized genetic elements, provide a framework for theoretical modeling. Here, with the use of a combinatorial method, a library of networks with varying connectivity was generated in Escherichia coli. These networks were composed of genes encoding the transcriptional regulators Lacl, TetR, and lambda Cl, as well as the corresponding promoters. They displayed phenotypic behaviors resembling binary logical circuits, with two chemical “inputs” and a fluorescent protein “output.” Within this simple system, diverse computational functions arose through changes in network connectivity. Combinatorial synthesis provides an alternative approach for studying biological networks, as well as an efficient method for producing diverse phenotypes in vivo."}],"volume":296,"date_created":"2018-12-11T12:05:00Z"},{"author":[{"first_name":"Cheng","last_name":"Lien","full_name":"Lien, Cheng"},{"full_name":"Martina, Marco","first_name":"Marco","last_name":"Martina"},{"first_name":"Jobst","last_name":"Schultz","full_name":"Schultz, Jobst"},{"last_name":"Ehmke","first_name":"Heimo","full_name":"Ehmke, Heimo"},{"id":"353C1B58-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5001-4804","full_name":"Jonas, Peter M","first_name":"Peter M","last_name":"Jonas"}],"day":"01","title":"Gating, modulation and subunit composition of voltage-gated K(+) channels in dendritic inhibitory interneurones of rat hippocampus","publist_id":"2411","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publisher":"Wiley-Blackwell","pmid":1,"publication":"Journal of Physiology","article_type":"original","article_processing_charge":"No","publication_identifier":{"issn":["0022-3751"]},"doi":"10.1113/jphysiol.2001.013066","quality_controlled":"1","issue":"Pt 2","language":[{"iso":"eng"}],"page":"405 - 419","oa_version":"Published Version","month":"01","type":"journal_article","date_updated":"2023-07-11T12:32:26Z","abstract":[{"text":"GABAergic interneurones are diverse in their morphological and functional properties. Perisomatic inhibitory cells show fast spiking during sustained current injection, whereas dendritic inhibitory cells fire action potentials with lower frequency. We examined functional and molecular properties of K(+) channels in interneurones with horizontal dendrites in stratum oriens-alveus (OA) of the hippocampal CA1 region, which mainly comprise somatostatin-positive dendritic inhibitory cells. Voltage-gated K(+) currents in nucleated patches isolated from OA interneurones consisted of three major components: a fast delayed rectifier K(+) current component that was highly sensitive to external 4-aminopyridine (4-AP) and tetraethylammonium (TEA) (half-maximal inhibitory concentrations &lt; 0.1 mM for both blockers), a slow delayed rectifier K(+) current component that was sensitive to high concentrations of TEA, but insensitive to 4-AP, and a rapidly inactivating A-type K(+) current component that was blocked by high concentrations of 4-AP, but resistant to TEA. The relative contributions of these components to the macroscopic K(+) current were estimated as 57 +/- 5, 25 +/- 6, and 19 +/- 2 %, respectively. Dendrotoxin, a selective blocker of Kv1 channels had only minimal effects on K(+) currents in nucleated patches. Coapplication of the membrane-permeant cAMP analogue 8-(4-chlorophenylthio)-adenosine 3':5'-cyclic monophosphate (cpt-cAMP) and the phosphodiesterase blocker isobutyl-methylxanthine (IBMX) resulted in a selective inhibition of the fast delayed rectifier K(+) current component. This inhibition was absent in the presence of the protein kinase A (PKA) inhibitor H-89, implying the involvement of PKA-mediated phosphorylation. Single-cell reverse transcription-polymerase chain reaction (RT-PCR) analysis revealed a high abundance of Kv3.2 mRNA in OA interneurones, whereas the expression level of Kv3.1 mRNA was markedly lower. Similarly, RT-PCR analysis showed a high abundance of Kv4.3 mRNA, whereas Kv4.2 mRNA was undetectable. This suggests that the fast delayed rectifier K(+) current and the A-type K(+) current component are mediated predominantly by homomeric Kv3.2 and Kv4.3 channels. Selective modulation of Kv3.2 channels in OA interneurones by cAMP is likely to be an important factor regulating the activity of dendritic inhibitory cells in principal neurone-interneurone microcircuits.","lang":"eng"}],"volume":538,"date_created":"2018-12-11T12:05:14Z","acknowledgement":"We thank Drs J. Bischofberger, M. Heckmann, and I. Vida for critically reading the manuscript, and A. Blomenkamp and K. Winterhalter for technical assistance. This work was supported by a scholarship from the Deutscher Akademischer Austansch dienst to C.-C. L., a Deutsche Forschungsgemeinschaft grant to P. J. (SFB 505/C5), and the Alexander-von-Humboldt foundation.","year":"2002","_id":"3799","oa":1,"publication_status":"published","date_published":"2002-01-01T00:00:00Z","main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2290075/","open_access":"1"}],"external_id":{"pmid":["11790809"]},"status":"public","extern":"1","intvolume":"       538","citation":{"short":"C. Lien, M. Martina, J. Schultz, H. Ehmke, P.M. Jonas, Journal of Physiology 538 (2002) 405–419.","chicago":"Lien, Cheng, Marco Martina, Jobst Schultz, Heimo Ehmke, and Peter M Jonas. “Gating, Modulation and Subunit Composition of Voltage-Gated K(+) Channels in Dendritic Inhibitory Interneurones of Rat Hippocampus.” <i>Journal of Physiology</i>. Wiley-Blackwell, 2002. <a href=\"https://doi.org/10.1113/jphysiol.2001.013066\">https://doi.org/10.1113/jphysiol.2001.013066</a>.","ieee":"C. Lien, M. Martina, J. Schultz, H. Ehmke, and P. M. Jonas, “Gating, modulation and subunit composition of voltage-gated K(+) channels in dendritic inhibitory interneurones of rat hippocampus,” <i>Journal of Physiology</i>, vol. 538, no. Pt 2. Wiley-Blackwell, pp. 405–419, 2002.","apa":"Lien, C., Martina, M., Schultz, J., Ehmke, H., &#38; Jonas, P. M. (2002). Gating, modulation and subunit composition of voltage-gated K(+) channels in dendritic inhibitory interneurones of rat hippocampus. <i>Journal of Physiology</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1113/jphysiol.2001.013066\">https://doi.org/10.1113/jphysiol.2001.013066</a>","mla":"Lien, Cheng, et al. “Gating, Modulation and Subunit Composition of Voltage-Gated K(+) Channels in Dendritic Inhibitory Interneurones of Rat Hippocampus.” <i>Journal of Physiology</i>, vol. 538, no. Pt 2, Wiley-Blackwell, 2002, pp. 405–19, doi:<a href=\"https://doi.org/10.1113/jphysiol.2001.013066\">10.1113/jphysiol.2001.013066</a>.","ista":"Lien C, Martina M, Schultz J, Ehmke H, Jonas PM. 2002. Gating, modulation and subunit composition of voltage-gated K(+) channels in dendritic inhibitory interneurones of rat hippocampus. Journal of Physiology. 538(Pt 2), 405–419.","ama":"Lien C, Martina M, Schultz J, Ehmke H, Jonas PM. Gating, modulation and subunit composition of voltage-gated K(+) channels in dendritic inhibitory interneurones of rat hippocampus. <i>Journal of Physiology</i>. 2002;538(Pt 2):405-419. doi:<a href=\"https://doi.org/10.1113/jphysiol.2001.013066\">10.1113/jphysiol.2001.013066</a>"}},{"extern":"1","intvolume":"        99","citation":{"short":"M. Bartos, I. Vida, M. Frotscher, A. Meyer, H. Monyer, J. Geiger, P.M. Jonas, PNAS 99 (2002) 13222–13227.","chicago":"Bartos, Marlene, Imre Vida, Michael Frotscher, Axel Meyer, Hannah Monyer, Jörg Geiger, and Peter M Jonas. “Fast Synaptic Inhibition Promotes Synchronized Gamma Oscillations in Hippocampal Interneuron Networks.” <i>PNAS</i>. National Academy of Sciences, 2002. <a href=\"https://doi.org/10.1073/pnas.192233099\">https://doi.org/10.1073/pnas.192233099</a>.","ieee":"M. Bartos <i>et al.</i>, “Fast synaptic inhibition promotes synchronized gamma oscillations in hippocampal interneuron networks,” <i>PNAS</i>, vol. 99, no. 20. National Academy of Sciences, pp. 13222–13227, 2002.","apa":"Bartos, M., Vida, I., Frotscher, M., Meyer, A., Monyer, H., Geiger, J., &#38; Jonas, P. M. (2002). Fast synaptic inhibition promotes synchronized gamma oscillations in hippocampal interneuron networks. <i>PNAS</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.192233099\">https://doi.org/10.1073/pnas.192233099</a>","ista":"Bartos M, Vida I, Frotscher M, Meyer A, Monyer H, Geiger J, Jonas PM. 2002. Fast synaptic inhibition promotes synchronized gamma oscillations in hippocampal interneuron networks. PNAS. 99(20), 13222–13227.","mla":"Bartos, Marlene, et al. “Fast Synaptic Inhibition Promotes Synchronized Gamma Oscillations in Hippocampal Interneuron Networks.” <i>PNAS</i>, vol. 99, no. 20, National Academy of Sciences, 2002, pp. 13222–27, doi:<a href=\"https://doi.org/10.1073/pnas.192233099\">10.1073/pnas.192233099</a>.","ama":"Bartos M, Vida I, Frotscher M, et al. Fast synaptic inhibition promotes synchronized gamma oscillations in hippocampal interneuron networks. <i>PNAS</i>. 2002;99(20):13222-13227. doi:<a href=\"https://doi.org/10.1073/pnas.192233099\">10.1073/pnas.192233099</a>"},"status":"public","external_id":{"pmid":["12235359"]},"date_published":"2002-09-16T00:00:00Z","main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC130614/"}],"oa":1,"publication_status":"published","_id":"3800","acknowledgement":"We thank Drs. J. Bischofberger, M. Heckmann, and R. Traub for critically reading the manuscript. This work was supported by Deutsche Forschungsgemeinschaft Grants SFB 505/C5 (to P.J.) and SFB 505/C6 (to M.F. and P.J.), Human Frontiers Science Program Organization Grant RG0017/1998-B (to P.J.), and grants from the Alexander-von-Humboldt Foundation (to P.J. and M.F.), the Schilling Foundation (to H.M.), and Novartis (to H.M.).","year":"2002","volume":99,"date_created":"2018-12-11T12:05:14Z","page":"13222 - 13227","abstract":[{"lang":"eng","text":"Networks of GABAergic interneurons are of critical importance for the generation of gamma frequency oscillations in the brain. To examine the underlying synaptic mechanisms, we made paired recordings from &quot;basket cells&quot; (BCs) in different subfields of hippocampal slices, using transgenic mice that express enhanced green fluorescent protein (EGFP) under the control of the parvalbumin promoter. Unitary inhibitory postsynaptic currents (IPSCs) showed large amplitude and fast time course with mean amplitude-weighted decay time constants of 2.5, 1.2, and 1.8 ms in the dentate gyrus, and the cornu ammonis area 3 (CA3) and 1 (CA1), respectively (33-34 degrees C). The decay of unitary IPSCs at BC-BC synapses was significantly faster than that at BC-principal cell synapses, indicating target cell-specific differences in IPSC kinetics. In addition, electrical coupling was found in a subset of BC-BC pairs. To examine whether an interneuron network with fast inhibitory synapses can act as a gamma frequency oscillator, we developed an interneuron network model based on experimentally determined properties. In comparison to previous interneuron network models, our model was able to generate oscillatory activity with higher coherence over a broad range of frequencies (20-110 Hz). In this model, high coherence and flexibility in frequency control emerge from the combination of synaptic properties, network structure, and electrical coupling."}],"date_updated":"2023-07-10T13:35:18Z","month":"09","type":"journal_article","oa_version":"Published Version","language":[{"iso":"eng"}],"issue":"20","doi":"10.1073/pnas.192233099","quality_controlled":"1","publication_identifier":{"issn":["0027-8424"]},"publication":"PNAS","article_processing_charge":"No","scopus_import":"1","article_type":"original","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publisher":"National Academy of Sciences","pmid":1,"title":"Fast synaptic inhibition promotes synchronized gamma oscillations in hippocampal interneuron networks","publist_id":"2409","author":[{"full_name":"Bartos, Marlene","first_name":"Marlene","last_name":"Bartos"},{"full_name":"Vida, Imre","first_name":"Imre","last_name":"Vida"},{"last_name":"Frotscher","first_name":"Michael","full_name":"Frotscher, Michael"},{"first_name":"Axel","last_name":"Meyer","full_name":"Meyer, Axel"},{"first_name":"Hannah","last_name":"Monyer","full_name":"Monyer, Hannah"},{"full_name":"Geiger, Jörg","last_name":"Geiger","first_name":"Jörg"},{"first_name":"Peter M","last_name":"Jonas","full_name":"Jonas, Peter M","orcid":"0000-0001-5001-4804","id":"353C1B58-F248-11E8-B48F-1D18A9856A87"}],"day":"16"},{"year":"2002","acknowledgement":"We  thank  Drs  M.  Bartos,  J.  Bischofberger,  M.  Heckmann  and I. Vida  for  critically  reading  the  manuscript,  Dr  K.  Götz  for providing  information  about  pharmacological  properties  of inhibitory  hippocampal  synapses,  and  A.  Blomenkamp  and K. Winterhalter for technical assistance. This work was supported by Deutsche Forschungsgemeinschaft grants to P.J. (Jo-248/2-2,SFB 505/C5) and the Alexander-von-Humboldt foundation.","_id":"3801","abstract":[{"text":"To examine possible interactions between fast depression and modulation of inhibitory synaptic transmission in the hippocampus, we recorded from pairs of synaptically connected basket cells (BCs) and granule cells (GCs) in the dentate gyrus of rat brain slices at 34 degrees C. Multiple-pulse depression (MPD) was examined in trains of 5 or 10 inhibitory postsynaptic currents (IPSCs) evoked at frequencies of 10-100 Hz under several conditions that inhibit transmitter release: block of voltage-dependent Ca2+ channels by Cd2+ (10 microM), activation of gamma-amino-butyric acid type B receptors (GABA(B)Rs) by baclofen (10 microM) and activation of muscarinic acetylcholine receptors (mAchRs) by carbachol (2 microM). All manipulations led to a substantial inhibition of synaptic transmission, reducing the amplitude of the first IPSC in the train (IPSC1) by 72%, 61% and 29%, respectively. However, MPD was largely preserved under these conditions (0.34 in control versus 0.31, 0.50 and 0.47 in the respective conditions at 50 Hz). Similarly, a theta burst stimulation (TBS) protocol reduced IPSC1 by 54%, but left MPD unchanged (0.40 in control and 0.39 during TBS). Analysis of both fractions of transmission failures and coefficients of variation (CV) of IPSC peak amplitudes suggested that MPD had a presynaptic expression site, independent of release probability. In conclusion, different types of presynaptic modulation of inhibitory synaptic transmission converge on a reduction of synaptic strength, while short-term dynamics are largely unchanged.","lang":"eng"}],"date_updated":"2023-07-11T10:01:12Z","oa_version":"Published Version","month":"02","type":"journal_article","page":"201 - 8","date_created":"2018-12-11T12:05:15Z","volume":539,"status":"public","external_id":{"pmid":["11850513"]},"citation":{"ama":"Hefft S, Kraushaar U, Geiger J, Jonas PM. Presynaptic short-term depression is maintained during regulation of transmitter release at a GABAergic synapse in rat hippocampus. <i>Journal of Physiology</i>. 2002;539(Pt 1):201-208. doi:<a href=\"https://doi.org/10.1113/jphysiol.2001.013455\">10.1113/jphysiol.2001.013455</a>","mla":"Hefft, Stefan, et al. “Presynaptic Short-Term Depression Is Maintained during Regulation of Transmitter Release at a GABAergic Synapse in Rat Hippocampus.” <i>Journal of Physiology</i>, vol. 539, no. Pt 1, Wiley-Blackwell, 2002, pp. 201–08, doi:<a href=\"https://doi.org/10.1113/jphysiol.2001.013455\">10.1113/jphysiol.2001.013455</a>.","ista":"Hefft S, Kraushaar U, Geiger J, Jonas PM. 2002. Presynaptic short-term depression is maintained during regulation of transmitter release at a GABAergic synapse in rat hippocampus. Journal of Physiology. 539(Pt 1), 201–8.","apa":"Hefft, S., Kraushaar, U., Geiger, J., &#38; Jonas, P. M. (2002). Presynaptic short-term depression is maintained during regulation of transmitter release at a GABAergic synapse in rat hippocampus. <i>Journal of Physiology</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1113/jphysiol.2001.013455\">https://doi.org/10.1113/jphysiol.2001.013455</a>","ieee":"S. Hefft, U. Kraushaar, J. Geiger, and P. M. Jonas, “Presynaptic short-term depression is maintained during regulation of transmitter release at a GABAergic synapse in rat hippocampus,” <i>Journal of Physiology</i>, vol. 539, no. Pt 1. Wiley-Blackwell, pp. 201–8, 2002.","chicago":"Hefft, Stefan, Udo Kraushaar, Jörg Geiger, and Peter M Jonas. “Presynaptic Short-Term Depression Is Maintained during Regulation of Transmitter Release at a GABAergic Synapse in Rat Hippocampus.” <i>Journal of Physiology</i>. Wiley-Blackwell, 2002. <a href=\"https://doi.org/10.1113/jphysiol.2001.013455\">https://doi.org/10.1113/jphysiol.2001.013455</a>.","short":"S. Hefft, U. Kraushaar, J. Geiger, P.M. Jonas, Journal of Physiology 539 (2002) 201–8."},"intvolume":"       539","extern":"1","oa":1,"publication_status":"published","main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2290140/","open_access":"1"}],"date_published":"2002-02-01T00:00:00Z","pmid":1,"publisher":"Wiley-Blackwell","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","scopus_import":"1","article_type":"original","publication":"Journal of Physiology","day":"01","author":[{"full_name":"Hefft, Stefan","first_name":"Stefan","last_name":"Hefft"},{"full_name":"Kraushaar, Udo","last_name":"Kraushaar","first_name":"Udo"},{"first_name":"Jörg","last_name":"Geiger","full_name":"Geiger, Jörg"},{"id":"353C1B58-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5001-4804","full_name":"Jonas, Peter M","last_name":"Jonas","first_name":"Peter M"}],"publist_id":"2410","title":"Presynaptic short-term depression is maintained during regulation of transmitter release at a GABAergic synapse in rat hippocampus","language":[{"iso":"eng"}],"issue":"Pt 1","publication_identifier":{"issn":["0022-3751"]},"quality_controlled":"1","doi":"10.1113/jphysiol.2001.013455"},{"title":"Timing and efficacy of Ca(2+) channel activation in hippocampal mossy fiber boutons","publist_id":"2407","author":[{"first_name":"Josef","last_name":"Bischofberger","full_name":"Bischofberger, Josef"},{"full_name":"Geiger, Jörg","last_name":"Geiger","first_name":"Jörg"},{"full_name":"Jonas, Peter M","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5001-4804","last_name":"Jonas","first_name":"Peter M"}],"day":"01","publication":"Journal of Neuroscience","article_type":"original","scopus_import":"1","article_processing_charge":"No","publisher":"Society for Neuroscience","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","pmid":1,"doi":"10.1523/JNEUROSCI.22-24-10593.2002","quality_controlled":"1","publication_identifier":{"issn":["0270-6474"]},"issue":"24","language":[{"iso":"eng"}],"volume":22,"date_created":"2018-12-11T12:05:15Z","page":"10593 - 10602","oa_version":"Published Version","type":"journal_article","month":"12","abstract":[{"text":"The presynaptic Ca2+ signal is a key determinant of transmitter release at chemical synapses. In cortical synaptic terminals, however, little is known about the kinetic properties of the presynaptic Ca2+ channels. To investigate the timing and magnitude of the presynaptic Ca2+ inflow, we performed whole-cell patch-clamp recordings from mossy fiber boutons (MFBs) in rat hippocampus. MFBs showed large high-voltage-activated Ca(2+) currents, with a maximal amplitude of approximately 100 pA at a membrane potential of 0 mV. Both activation and deactivation were fast, with time constants in the submillisecond range at a temperature of approximately 23 degrees C. An MFB action potential (AP) applied as a voltage-clamp command evoked a transient Ca2+ current with an average amplitude of approximately 170 pA and a half-duration of 580 microsec. A prepulse to +40 mV had only minimal effects on the AP-evoked Ca2+ current, indicating that presynaptic APs open the voltage-gated Ca2+ channels very effectively. On the basis of the experimental data, we developed a kinetic model with four closed states and one open state, linked by voltage-dependent rate constants. Simulations of the Ca2+ current could reproduce the experimental data, including the large amplitude and rapid time course of the current evoked by MFB APs. Furthermore, the simulations indicate that the shape of the presynaptic AP and the gating kinetics of the Ca2+ channels are tuned to produce a maximal Ca2+ influx during a minimal period of time. The precise timing and high efficacy of Ca2+ channel activation at this cortical glutamatergic synapse may be important for synchronous transmitter release and temporal information processing.","lang":"eng"}],"date_updated":"2023-06-13T13:19:45Z","_id":"3802","acknowledgement":"J.B. was supported by grants from the Deutsche Forschungsgemeinschaft (Bi 642/1-2 and SFB 505/C9). We thank Dr. U. Kraushaar, Dr. S. Hefft, and C. Schmidt-Hieber for critically reading this manuscript, F. Heyde for secretarial help, and A. Blomenkamp and K. Winterhalter for technical assistance.","year":"2002","date_published":"2002-12-01T00:00:00Z","main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6758411/","open_access":"1"}],"oa":1,"publication_status":"published","intvolume":"        22","extern":"1","citation":{"short":"J. Bischofberger, J. Geiger, P.M. Jonas, Journal of Neuroscience 22 (2002) 10593–10602.","chicago":"Bischofberger, Josef, Jörg Geiger, and Peter M Jonas. “Timing and Efficacy of Ca(2+) Channel Activation in Hippocampal Mossy Fiber Boutons.” <i>Journal of Neuroscience</i>. Society for Neuroscience, 2002. <a href=\"https://doi.org/10.1523/JNEUROSCI.22-24-10593.2002\">https://doi.org/10.1523/JNEUROSCI.22-24-10593.2002</a>.","ieee":"J. Bischofberger, J. Geiger, and P. M. Jonas, “Timing and efficacy of Ca(2+) channel activation in hippocampal mossy fiber boutons,” <i>Journal of Neuroscience</i>, vol. 22, no. 24. Society for Neuroscience, pp. 10593–10602, 2002.","apa":"Bischofberger, J., Geiger, J., &#38; Jonas, P. M. (2002). Timing and efficacy of Ca(2+) channel activation in hippocampal mossy fiber boutons. <i>Journal of Neuroscience</i>. Society for Neuroscience. <a href=\"https://doi.org/10.1523/JNEUROSCI.22-24-10593.2002\">https://doi.org/10.1523/JNEUROSCI.22-24-10593.2002</a>","mla":"Bischofberger, Josef, et al. “Timing and Efficacy of Ca(2+) Channel Activation in Hippocampal Mossy Fiber Boutons.” <i>Journal of Neuroscience</i>, vol. 22, no. 24, Society for Neuroscience, 2002, pp. 10593–602, doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.22-24-10593.2002\">10.1523/JNEUROSCI.22-24-10593.2002</a>.","ista":"Bischofberger J, Geiger J, Jonas PM. 2002. Timing and efficacy of Ca(2+) channel activation in hippocampal mossy fiber boutons. Journal of Neuroscience. 22(24), 10593–10602.","ama":"Bischofberger J, Geiger J, Jonas PM. Timing and efficacy of Ca(2+) channel activation in hippocampal mossy fiber boutons. <i>Journal of Neuroscience</i>. 2002;22(24):10593-10602. doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.22-24-10593.2002\">10.1523/JNEUROSCI.22-24-10593.2002</a>"},"status":"public","external_id":{"pmid":["12486151"]}},{"doi":"10.1016/S0166-2236(02)02259-2","quality_controlled":"1","publication_identifier":{"issn":["0166-2236"]},"language":[{"iso":"eng"}],"issue":"12","title":"TwoB or not twoB: differential transmission at glutamatergic mossy fiber-interneuron synapses in the hippocampus","publist_id":"2408","author":[{"full_name":"Bischofberger, Josef","first_name":"Josef","last_name":"Bischofberger"},{"orcid":"0000-0001-5001-4804","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","full_name":"Jonas, Peter M","first_name":"Peter M","last_name":"Jonas"}],"day":"01","publication":"Trends in Neurosciences","article_processing_charge":"No","article_type":"letter_note","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publisher":"Elsevier","pmid":1,"date_published":"2002-12-01T00:00:00Z","publication_status":"published","extern":"1","intvolume":"        25","citation":{"short":"J. Bischofberger, P.M. Jonas, Trends in Neurosciences 25 (2002) 600–603.","ieee":"J. Bischofberger and P. M. Jonas, “TwoB or not twoB: differential transmission at glutamatergic mossy fiber-interneuron synapses in the hippocampus,” <i>Trends in Neurosciences</i>, vol. 25, no. 12. Elsevier, pp. 600–603, 2002.","chicago":"Bischofberger, Josef, and Peter M Jonas. “TwoB or Not TwoB: Differential Transmission at Glutamatergic Mossy Fiber-Interneuron Synapses in the Hippocampus.” <i>Trends in Neurosciences</i>. Elsevier, 2002. <a href=\"https://doi.org/10.1016/S0166-2236(02)02259-2\">https://doi.org/10.1016/S0166-2236(02)02259-2</a>.","mla":"Bischofberger, Josef, and Peter M. Jonas. “TwoB or Not TwoB: Differential Transmission at Glutamatergic Mossy Fiber-Interneuron Synapses in the Hippocampus.” <i>Trends in Neurosciences</i>, vol. 25, no. 12, Elsevier, 2002, pp. 600–03, doi:<a href=\"https://doi.org/10.1016/S0166-2236(02)02259-2\">10.1016/S0166-2236(02)02259-2</a>.","ista":"Bischofberger J, Jonas PM. 2002. TwoB or not twoB: differential transmission at glutamatergic mossy fiber-interneuron synapses in the hippocampus. Trends in Neurosciences. 25(12), 600–603.","apa":"Bischofberger, J., &#38; Jonas, P. M. (2002). TwoB or not twoB: differential transmission at glutamatergic mossy fiber-interneuron synapses in the hippocampus. <i>Trends in Neurosciences</i>. Elsevier. <a href=\"https://doi.org/10.1016/S0166-2236(02)02259-2\">https://doi.org/10.1016/S0166-2236(02)02259-2</a>","ama":"Bischofberger J, Jonas PM. TwoB or not twoB: differential transmission at glutamatergic mossy fiber-interneuron synapses in the hippocampus. <i>Trends in Neurosciences</i>. 2002;25(12):600-603. doi:<a href=\"https://doi.org/10.1016/S0166-2236(02)02259-2\">10.1016/S0166-2236(02)02259-2</a>"},"external_id":{"pmid":["12446120"]},"status":"public","volume":25,"date_created":"2018-12-11T12:05:15Z","page":"600 - 603","date_updated":"2023-07-10T13:22:24Z","abstract":[{"text":"Mossy fiber (MF) synapses are key stations for flow of information through the hippocampal formation. A major component of the output of the MF system is directed towards inhibitory interneurons. Recent studies have revealed that the functional properties of MF-interneuron synapses differ substantially from those of MF-CA3 pyramidal neuron synapses. Mossy-fiber-interneuron synapses in the stratum lucidum represent a continuum of functional subtypes, in which the subunit composition of postsynaptic AMPA receptors and NMDA receptors appears to be regulated in a coordinated manner.","lang":"eng"}],"month":"12","type":"journal_article","oa_version":"None","_id":"3803","year":"2002"},{"citation":{"mla":"Cremer, Sylvia, and Jürgen Heinze. “Adaptive Production of Fighter Males: Queens of the Ant Cardiocondyla Adjust the Sex Ratio under Local Mate Competition.” <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>, vol. 269, no. 1489, Royal Society, The, 2002, pp. 417–22, doi:<a href=\"https://doi.org/10.1098/rspb.2001.1892\">10.1098/rspb.2001.1892</a>.","ista":"Cremer S, Heinze J. 2002. Adaptive production of fighter males: queens of the ant Cardiocondyla adjust the sex ratio under local mate competition. Proceedings of the Royal Society of London Series B Biological Sciences. 269(1489), 417–422.","apa":"Cremer, S., &#38; Heinze, J. (2002). Adaptive production of fighter males: queens of the ant Cardiocondyla adjust the sex ratio under local mate competition. <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>. Royal Society, The. <a href=\"https://doi.org/10.1098/rspb.2001.1892\">https://doi.org/10.1098/rspb.2001.1892</a>","ama":"Cremer S, Heinze J. Adaptive production of fighter males: queens of the ant Cardiocondyla adjust the sex ratio under local mate competition. <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>. 2002;269(1489):417-422. doi:<a href=\"https://doi.org/10.1098/rspb.2001.1892\">10.1098/rspb.2001.1892</a>","short":"S. Cremer, J. Heinze, Proceedings of the Royal Society of London Series B Biological Sciences 269 (2002) 417–422.","ieee":"S. Cremer and J. Heinze, “Adaptive production of fighter males: queens of the ant Cardiocondyla adjust the sex ratio under local mate competition,” <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>, vol. 269, no. 1489. Royal Society, The, pp. 417–422, 2002.","chicago":"Cremer, Sylvia, and Jürgen Heinze. “Adaptive Production of Fighter Males: Queens of the Ant Cardiocondyla Adjust the Sex Ratio under Local Mate Competition.” <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>. Royal Society, The, 2002. <a href=\"https://doi.org/10.1098/rspb.2001.1892\">https://doi.org/10.1098/rspb.2001.1892</a>."},"intvolume":"       269","extern":"1","status":"public","external_id":{"pmid":["11886631"]},"main_file_link":[{"open_access":"1","url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1690910/"}],"date_published":"2002-02-22T00:00:00Z","publication_status":"published","oa":1,"_id":"3919","year":"2002","acknowledgement":"We thank A. F. G. Bourke, J. J. Boomsma, S. Foitzik, M. Sixt,C. Anderson and C. Schubart for improving the manuscript, and  E.  Sixt  for  ant  illustrations  (figure  2).  This  study  was funded  by  the  DFG  (Deutsche  Forschungsgemeinschaft:  He1623/7-2).","date_created":"2018-12-11T12:05:53Z","volume":269,"abstract":[{"text":"Hamilton's concept of local mate competition (LMC) is the standard model to explain female-biased sex ratios in solitary Hymenoptera. In social Hymenoptera, however, LMC has remained controversial, mainly because manipulation of sex allocation by workers in response to relatedness asymmetries is an additional powerful mechanism of female bias. Furthermore, the predominant mating systems in the social insects are thought to make LMC unlikely. Nevertheless, several species exist in which dispersal of males is limited and mating occurs in the nest. Some of these species, such as the ant Cardiocondyla obscurior, have evolved dimorphic males, with one morph being specialized for dispersal and the other for fighting with nest-mate males over access to females. Such life history, combining sociality and alternative reproductive tactics in males, provides a unique opportunity to test the power of LMC as a selective force leading to female-biased sex ratios in social Hymenoptera. We show that, in concordance with LMC predictions, an experimental increase in queen number leads to a shift in sex allocation in favour of non-dispersing males, but does not influence the proportion of disperser males. Furthermore, we can assign this change in sex allocation at the colony level to the queens and rule out worker manipulation.","lang":"eng"}],"date_updated":"2023-06-13T11:52:17Z","oa_version":"None","month":"02","type":"journal_article","page":"417 - 422","language":[{"iso":"eng"}],"issue":"1489","quality_controlled":"1","doi":"10.1098/rspb.2001.1892","publication_identifier":{"issn":["0962-8452"]},"scopus_import":"1","article_processing_charge":"No","article_type":"original","publication":"Proceedings of the Royal Society of London Series B Biological Sciences","pmid":1,"publisher":"Royal Society, The","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publist_id":"2231","title":"Adaptive production of fighter males: queens of the ant Cardiocondyla adjust the sex ratio under local mate competition","day":"22","author":[{"last_name":"Cremer","first_name":"Sylvia","full_name":"Cremer, Sylvia","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2193-3868"},{"first_name":"Jürgen","last_name":"Heinze","full_name":"Heinze, Jürgen"}]}]