[{"date_published":"2002-09-16T00:00:00Z","external_id":{"pmid":["12209836"]},"page":"189 - 199","publication_identifier":{"issn":["0021-9967"]},"scopus_import":"1","date_updated":"2023-07-25T09:09:48Z","type":"journal_article","oa_version":"None","day":"16","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","language":[{"iso":"eng"}],"doi":"10.1002/cne.10344","article_type":"original","publisher":"Wiley-Blackwell","volume":451,"issue":"2","date_created":"2018-12-11T11:58:42Z","month":"09","status":"public","intvolume":"       451","publist_id":"4279","year":"2002","citation":{"mla":"Nunzi, Maria, et al. “Differential Expression of Calretinin and Metabotropic Glutamate Receptor MGluR1α Defines Subsets of Unipolar Brush Cells in Mouse Cerebellum.” <i>Journal of Comparative Neurology</i>, vol. 451, no. 2, Wiley-Blackwell, 2002, pp. 189–99, doi:<a href=\"https://doi.org/10.1002/cne.10344\">10.1002/cne.10344</a>.","apa":"Nunzi, M., Shigemoto, R., &#38; Mugnaini, E. (2002). Differential expression of calretinin and metabotropic glutamate receptor mGluR1α defines subsets of unipolar brush cells in mouse cerebellum. <i>Journal of Comparative Neurology</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1002/cne.10344\">https://doi.org/10.1002/cne.10344</a>","chicago":"Nunzi, Maria, Ryuichi Shigemoto, and Enrico Mugnaini. “Differential Expression of Calretinin and Metabotropic Glutamate Receptor MGluR1α Defines Subsets of Unipolar Brush Cells in Mouse Cerebellum.” <i>Journal of Comparative Neurology</i>. Wiley-Blackwell, 2002. <a href=\"https://doi.org/10.1002/cne.10344\">https://doi.org/10.1002/cne.10344</a>.","short":"M. Nunzi, R. Shigemoto, E. Mugnaini, Journal of Comparative Neurology 451 (2002) 189–199.","ista":"Nunzi M, Shigemoto R, Mugnaini E. 2002. Differential expression of calretinin and metabotropic glutamate receptor mGluR1α defines subsets of unipolar brush cells in mouse cerebellum. Journal of Comparative Neurology. 451(2), 189–199.","ama":"Nunzi M, Shigemoto R, Mugnaini E. Differential expression of calretinin and metabotropic glutamate receptor mGluR1α defines subsets of unipolar brush cells in mouse cerebellum. <i>Journal of Comparative Neurology</i>. 2002;451(2):189-199. doi:<a href=\"https://doi.org/10.1002/cne.10344\">10.1002/cne.10344</a>","ieee":"M. Nunzi, R. Shigemoto, and E. Mugnaini, “Differential expression of calretinin and metabotropic glutamate receptor mGluR1α defines subsets of unipolar brush cells in mouse cerebellum,” <i>Journal of Comparative Neurology</i>, vol. 451, no. 2. Wiley-Blackwell, pp. 189–199, 2002."},"author":[{"full_name":"Nunzi, Maria","last_name":"Nunzi","first_name":"Maria"},{"full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","first_name":"Ryuichi"},{"full_name":"Mugnaini, Enrico","last_name":"Mugnaini","first_name":"Enrico"}],"extern":"1","quality_controlled":"1","publication_status":"published","abstract":[{"text":"The unipolar brush cell (UBC) is a type of glutamatergic interneuron in the granular layer of the cerebellum. The UBC brush and a single mossy fiber (MF) terminal contact each other within a cerebellar glomerulus, forming a giant synapse. Many UBCs receive input from extrinsic MFs, whereas others are innervated by intrinsic mossy terminals formed by the axons of other UBCs. In all mammalian species so far examined, the vestibulocerebellum is enriched of UBCs that are strongly immunoreactive for the calcium binding protein calretinin (CR) in both the somatodendritic and axonal compartment. UBCs have postsynaptic ionotropic glutamate receptors and extrasynaptic metabotropic glutamate receptors that immunocytochemically highlight their somatodendritic compartment and brush, respectively. In this study on the mouse cerebellum, we present evidence that immunoreactivities to CR and mGluR1α define two distinct UBC subsets with partly overlapping distributions in lobule X (the nodulus). In sections double-labeled for CR and mGluR1α, the patterns of distributions of CR+/mGluR1α- UBCs and CR-/mGluR1α+ UBCs differed along the mediolateral and dorsoventral axes of the folium. Moreover, mGluR1α+ UBCs outnumbered CR+ UBCs. Both UBC subsets were mGluR2/3, GluR2/3, and NMDAR1 immunoreactive. The different distribution patterns of the two UBC subsets within lobule X suggest that expression of CR or mGluR1α by UBCs may be afferent-specific and related to the terminal fields of different vestibular MF afferents.","lang":"eng"}],"publication":"Journal of Comparative Neurology","title":"Differential expression of calretinin and metabotropic glutamate receptor mGluR1α defines subsets of unipolar brush cells in mouse cerebellum","pmid":1,"_id":"2618"},{"extern":"1","author":[{"last_name":"Dalezios","first_name":"Yannis","full_name":"Dalezios, Yannis"},{"full_name":"Luján, Rafael","first_name":"Rafael","last_name":"Luján"},{"last_name":"Shigemoto","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi"},{"full_name":"Roberts, John","last_name":"Roberts","first_name":"John"},{"full_name":"Somogyi, Péter","last_name":"Somogyi","first_name":"Péter"}],"quality_controlled":"1","citation":{"ista":"Dalezios Y, Luján R, Shigemoto R, Roberts J, Somogyi P. 2002. Enrichment of mGluR7a in the Presynaptic active zones of GABAergic and Non-GABAergic terminals on interneurons in the rat somatosensory cortex. Cerebral Cortex. 12(9), 961–974.","chicago":"Dalezios, Yannis, Rafael Luján, Ryuichi Shigemoto, John Roberts, and Péter Somogyi. “Enrichment of MGluR7a in the Presynaptic Active Zones of GABAergic and Non-GABAergic Terminals on Interneurons in the Rat Somatosensory Cortex.” <i>Cerebral Cortex</i>. Oxford University Press, 2002. <a href=\"https://doi.org/10.1093/cercor/12.9.961\">https://doi.org/10.1093/cercor/12.9.961</a>.","short":"Y. Dalezios, R. Luján, R. Shigemoto, J. Roberts, P. Somogyi, Cerebral Cortex 12 (2002) 961–974.","ieee":"Y. Dalezios, R. Luján, R. Shigemoto, J. Roberts, and P. Somogyi, “Enrichment of mGluR7a in the Presynaptic active zones of GABAergic and Non-GABAergic terminals on interneurons in the rat somatosensory cortex,” <i>Cerebral Cortex</i>, vol. 12, no. 9. Oxford University Press, pp. 961–974, 2002.","ama":"Dalezios Y, Luján R, Shigemoto R, Roberts J, Somogyi P. Enrichment of mGluR7a in the Presynaptic active zones of GABAergic and Non-GABAergic terminals on interneurons in the rat somatosensory cortex. <i>Cerebral Cortex</i>. 2002;12(9):961-974. doi:<a href=\"https://doi.org/10.1093/cercor/12.9.961\">10.1093/cercor/12.9.961</a>","apa":"Dalezios, Y., Luján, R., Shigemoto, R., Roberts, J., &#38; Somogyi, P. (2002). Enrichment of mGluR7a in the Presynaptic active zones of GABAergic and Non-GABAergic terminals on interneurons in the rat somatosensory cortex. <i>Cerebral Cortex</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/cercor/12.9.961\">https://doi.org/10.1093/cercor/12.9.961</a>","mla":"Dalezios, Yannis, et al. “Enrichment of MGluR7a in the Presynaptic Active Zones of GABAergic and Non-GABAergic Terminals on Interneurons in the Rat Somatosensory Cortex.” <i>Cerebral Cortex</i>, vol. 12, no. 9, Oxford University Press, 2002, pp. 961–74, doi:<a href=\"https://doi.org/10.1093/cercor/12.9.961\">10.1093/cercor/12.9.961</a>."},"year":"2002","_id":"2619","pmid":1,"title":"Enrichment of mGluR7a in the Presynaptic active zones of GABAergic and Non-GABAergic terminals on interneurons in the rat somatosensory cortex","publication":"Cerebral Cortex","abstract":[{"lang":"eng","text":"The release of glutamate and GABA is modulated by presynaptic metabotropic glutamate receptors (mGluRs). We used immunocytochemical methods to define the location of the group III receptor mGluR7a in glutamatergic and GABAergic terminals innervating GABAergic interneurons and pyramidal cells. Immunoreactivity for mGluR7a was localized in the presynaptic active zone of both identified GABAergic and presumed glutamatergic terminals. Terminals innervating dendritic spines showed a variable level of receptor immunoreactivity, ranging from immunonegative to strongly immunopositive. The frequency of strongly mGluR7a positive terminals innervating the soma and dendrites of mGluR1α/somatostatin-expressing interneurons was very high relative to other neurons. On dendrites that received mGluR7a-enriched glutamatergic innervation, at least 80% of GABAergic terminals were immunopositive for mGluR7a. On such dendrites virtually all (95%) vasoactive intestinal polypeptide (VIP) positive (GABAergic) terminals were enriched in mGluR7a. The targets of VIP/mGluR7a-expressing terminals were mainly (88%) mGluR1α-expressing interneurons, which were mostly somatostatin immunopositive. Parvalbumin positive terminals were immunonegative for mGluR7a. Some parvalbumin immunoreactive dendrites received strongly mGluR7a positive terminals. The subcellular location, as well as the cell type and synapse-specific distribution of mGluR7a in isocortical neuronal circuits, is homologous to its distribution in the hippocampus. The specific location of mGluR7a in the presynaptic active zone of both glutamatergic and GABAergic synapses may be related to the proximity of calcium channels and the vesicle fusion machinery. The enrichment of mGluR7a in the main GABAergic, as well as in the glutamatergic, innervation of mGluR1α/somatostatin-expressing interneurons suggests that their activation is under unique regulation by extracellular glutamate."}],"publication_status":"published","volume":12,"issue":"9","publisher":"Oxford University Press","article_type":"original","publist_id":"4280","intvolume":"        12","status":"public","month":"09","date_created":"2018-12-11T11:58:42Z","article_processing_charge":"No","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","day":"01","oa_version":"None","date_updated":"2023-07-25T09:40:49Z","type":"journal_article","language":[{"iso":"eng"}],"doi":"10.1093/cercor/12.9.961","acknowledgement":"We thank Dr C. Paspalas for an initial contribution to the immunocytochemistry. We are grateful for the generous gifts of antibodies from Dr A. Buchan (anti-somatostatin, Department of Physiology, University of British Columbia, Canada), Dr M. Watanabe (anti-mGluR1α, Department of Anatomy, Hokkaido University School of Medicine, Sapporo) and Dr K. Tanaka (anti-GAD, Niigata University, Faculty of Medicine, Department of Neurology). We thank Dr F. Ferraguti for helpful suggestions during the project and for his comments on a previous version of the manuscript. We also thank Philip Cobden, Paul Jays and Laszlo Marton for assistance. Y.D. was supported by a Wellcome Trust Advanced Training Fellowship.","page":"961 - 974","external_id":{"pmid":["12183395"]},"date_published":"2002-09-01T00:00:00Z","scopus_import":"1","publication_identifier":{"issn":["1047-3211"]}},{"publist_id":"4278","intvolume":"         5","status":"public","date_created":"2018-12-11T11:58:43Z","month":"11","issue":"11","volume":5,"publisher":"Nature Publishing Group","article_type":"original","_id":"2620","publication":"Nature Neuroscience","title":"Polarized and compartment-dependent distribution of HCN1 in pyramidal cell dendrites","pmid":1,"publication_status":"published","abstract":[{"lang":"eng","text":"An ion channel's function depends largely on its location and density on neurons. Here we used high-resolution immunolocalization to determine the subcellular distribution of the hyperpolarization-activated and cyclic-nucleotide-gated channel subunit 1 (HCN1) in rat brain. Light microscopy revealed graded HCN1 immunoreactivity in apical dendrites of hippocampal, subicular and neocortical layer-5 pyramidal cells. Quantitative comparison of immunogold densities showed a 60-fold increase from somatic to distal apical dendritic membranes. Distal dendritic shafts had 16 times more HCN1 labeling than proximal dendrites of similar diameters. At the same distance from the soma, the density of HCN1 was significantly higher in dendritic shafts than in spines. Our results reveal the complex cell surface distribution of voltage-gated ion-channels, and predict its role in increasing the computational power of single neurons via subcellular domain and input-specific mechanisms."}],"author":[{"last_name":"Lörincz","first_name":"Andrea","full_name":"Lörincz, Andrea"},{"full_name":"Notomi, Takuya","first_name":"Takuya","last_name":"Notomi"},{"last_name":"Tamás","first_name":"Gábor","full_name":"Tamás, Gábor"},{"last_name":"Shigemoto","first_name":"Ryuichi","orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Nusser, Zoltán","first_name":"Zoltán","last_name":"Nusser"}],"extern":"1","quality_controlled":"1","citation":{"mla":"Lörincz, Andrea, et al. “Polarized and Compartment-Dependent Distribution of HCN1 in Pyramidal Cell Dendrites.” <i>Nature Neuroscience</i>, vol. 5, no. 11, Nature Publishing Group, 2002, pp. 1185–93, doi:<a href=\"https://doi.org/10.1038/nn962\">10.1038/nn962</a>.","apa":"Lörincz, A., Notomi, T., Tamás, G., Shigemoto, R., &#38; Nusser, Z. (2002). Polarized and compartment-dependent distribution of HCN1 in pyramidal cell dendrites. <i>Nature Neuroscience</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/nn962\">https://doi.org/10.1038/nn962</a>","ama":"Lörincz A, Notomi T, Tamás G, Shigemoto R, Nusser Z. Polarized and compartment-dependent distribution of HCN1 in pyramidal cell dendrites. <i>Nature Neuroscience</i>. 2002;5(11):1185-1193. doi:<a href=\"https://doi.org/10.1038/nn962\">10.1038/nn962</a>","ieee":"A. Lörincz, T. Notomi, G. Tamás, R. Shigemoto, and Z. Nusser, “Polarized and compartment-dependent distribution of HCN1 in pyramidal cell dendrites,” <i>Nature Neuroscience</i>, vol. 5, no. 11. Nature Publishing Group, pp. 1185–1193, 2002.","short":"A. Lörincz, T. Notomi, G. Tamás, R. Shigemoto, Z. Nusser, Nature Neuroscience 5 (2002) 1185–1193.","chicago":"Lörincz, Andrea, Takuya Notomi, Gábor Tamás, Ryuichi Shigemoto, and Zoltán Nusser. “Polarized and Compartment-Dependent Distribution of HCN1 in Pyramidal Cell Dendrites.” <i>Nature Neuroscience</i>. Nature Publishing Group, 2002. <a href=\"https://doi.org/10.1038/nn962\">https://doi.org/10.1038/nn962</a>.","ista":"Lörincz A, Notomi T, Tamás G, Shigemoto R, Nusser Z. 2002. Polarized and compartment-dependent distribution of HCN1 in pyramidal cell dendrites. Nature Neuroscience. 5(11), 1185–1193."},"year":"2002","publication_identifier":{"issn":["1097-6256"]},"scopus_import":"1","page":"1185 - 1193","date_published":"2002-11-01T00:00:00Z","external_id":{"pmid":["12389030"]},"language":[{"iso":"eng"}],"doi":"10.1038/nn962","acknowledgement":"Z.N. received grants from the Hungarian Science Foundation (T032309), the Howard Hughes Medical Institute, the James S. McDonnell Foundation, the Wellcome Trust and the Boehringer Ingelheim Fund. Z.N. and R.S. received grants from CREST—Japan Science and Technology Corporation. G.T. is funded by the Wellcome Trust.","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","day":"01","type":"journal_article","date_updated":"2023-07-25T09:02:48Z","oa_version":"None"},{"publication_status":"published","abstract":[{"text":"The release properties of glutamatergic nerve terminals are influenced by a number of factors, including the subtype of voltage-dependent calcium channel and the presence of presynaptic autoreceptors. Group III metabotropic glutamate receptors (mGluRs) mediate feedback inhibition of glutamate release by inhibiting Ca2+ channel activity. By imaging Ca2+ in preparations of cerebrocortical nerve terminals, we show that voltage-dependent Ca2+ channels are distributed in a heterogeneous manner in individual nerve terminals. Presynaptic terminals contained only N-type (47.5%; conotoxin GVIA-sensitive), P/Q-type (3.9%; agatoxin IVA-sensitive), or both N- and P/Q-type (42.6%) Ca2+ channels, although the remainder of the terminals (6.1%) were insensitive to these two toxins. In this preparation, two mGluRs with high and low affinity for L(+)-2-amino-4-phosphonobutyrate were identified by immunocytochemistry as mGluR4 and mGluR7, respectively. These receptors were responsible for 22.2 and 24.1% reduction of glutamate release, and they reduced the Ca2+ response in 24.4 and 30.3% of the nerve terminals, respectively. Interestingly, mGluR4 was largely (73.7%) located in nerve terminals expressing both N- and P/Q-type Ca2+ channels, whereas mGluR7 was predominantly (69.9%) located in N-type Ca2+ channel-expressing terminals. This specific coexpression of different group III mGluRs and Ca2+ channels may endow synaptic terminals with distinct release properties and reveals the existence of a high degree of presynaptic heterogeneity.","lang":"eng"}],"_id":"2621","title":"Subtype-specific expression of Group III metabotropic glutamate receptors and Ca2+ channels in single nerve terminals","publication":"Journal of Biological Chemistry","pmid":1,"year":"2002","quality_controlled":"1","author":[{"first_name":"Carmelo","last_name":"Millán","full_name":"Millán, Carmelo"},{"last_name":"Luján","first_name":"Rafael","full_name":"Luján, Rafael"},{"last_name":"Shigemoto","first_name":"Ryuichi","full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"first_name":"José","last_name":"Sánchez Prieto","full_name":"Sánchez Prieto, José"}],"extern":"1","citation":{"mla":"Millán, Carmelo, et al. “Subtype-Specific Expression of Group III Metabotropic Glutamate Receptors and Ca2+ Channels in Single Nerve Terminals.” <i>Journal of Biological Chemistry</i>, vol. 277, no. 49, American Society for Biochemistry and Molecular Biology, 2002, pp. 47796–803, doi:<a href=\"https://doi.org/10.1074/jbc.M207531200\">10.1074/jbc.M207531200</a>.","apa":"Millán, C., Luján, R., Shigemoto, R., &#38; Sánchez Prieto, J. (2002). Subtype-specific expression of Group III metabotropic glutamate receptors and Ca2+ channels in single nerve terminals. <i>Journal of Biological Chemistry</i>. American Society for Biochemistry and Molecular Biology. <a href=\"https://doi.org/10.1074/jbc.M207531200\">https://doi.org/10.1074/jbc.M207531200</a>","ista":"Millán C, Luján R, Shigemoto R, Sánchez Prieto J. 2002. Subtype-specific expression of Group III metabotropic glutamate receptors and Ca2+ channels in single nerve terminals. Journal of Biological Chemistry. 277(49), 47796–47803.","chicago":"Millán, Carmelo, Rafael Luján, Ryuichi Shigemoto, and José Sánchez Prieto. “Subtype-Specific Expression of Group III Metabotropic Glutamate Receptors and Ca2+ Channels in Single Nerve Terminals.” <i>Journal of Biological Chemistry</i>. American Society for Biochemistry and Molecular Biology, 2002. <a href=\"https://doi.org/10.1074/jbc.M207531200\">https://doi.org/10.1074/jbc.M207531200</a>.","short":"C. Millán, R. Luján, R. Shigemoto, J. Sánchez Prieto, Journal of Biological Chemistry 277 (2002) 47796–47803.","ama":"Millán C, Luján R, Shigemoto R, Sánchez Prieto J. Subtype-specific expression of Group III metabotropic glutamate receptors and Ca2+ channels in single nerve terminals. <i>Journal of Biological Chemistry</i>. 2002;277(49):47796-47803. doi:<a href=\"https://doi.org/10.1074/jbc.M207531200\">10.1074/jbc.M207531200</a>","ieee":"C. Millán, R. Luján, R. Shigemoto, and J. Sánchez Prieto, “Subtype-specific expression of Group III metabotropic glutamate receptors and Ca2+ channels in single nerve terminals,” <i>Journal of Biological Chemistry</i>, vol. 277, no. 49. American Society for Biochemistry and Molecular Biology, pp. 47796–47803, 2002."},"status":"public","date_created":"2018-12-11T11:58:43Z","month":"12","publist_id":"4277","intvolume":"       277","article_type":"original","publisher":"American Society for Biochemistry and Molecular Biology","issue":"49","volume":277,"acknowledgement":"We thank M. Sefton for editorial assistance.","doi":"10.1074/jbc.M207531200","language":[{"iso":"eng"}],"day":"02","type":"journal_article","date_updated":"2023-07-19T07:49:19Z","oa_version":"Published Version","article_processing_charge":"No","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publication_identifier":{"issn":["0021-9258"]},"scopus_import":"1","page":"47796 - 47803","date_published":"2002-12-02T00:00:00Z","external_id":{"pmid":["12376542"]}},{"publisher":"Wiley-Blackwell","article_type":"original","volume":15,"issue":"11","status":"public","month":"06","date_created":"2018-12-11T11:58:43Z","publist_id":"4276","intvolume":"        15","year":"2002","quality_controlled":"1","extern":"1","author":[{"full_name":"López Bendito, Guillermina","last_name":"López Bendito","first_name":"Guillermina"},{"orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","first_name":"Ryuichi"},{"last_name":"Kulik","first_name":"Ákos","full_name":"Kulik, Ákos"},{"last_name":"Paulsen","first_name":"Ole","full_name":"Paulsen, Ole"},{"first_name":"Alfonso","last_name":"Fairén","full_name":"Fairén, Alfonso"},{"first_name":"Rafael","last_name":"Luján","full_name":"Luján, Rafael"}],"citation":{"short":"G. López Bendito, R. Shigemoto, Á. Kulik, O. Paulsen, A. Fairén, R. Luján, European Journal of Neuroscience 15 (2002) 1766–1778.","chicago":"López Bendito, Guillermina, Ryuichi Shigemoto, Ákos Kulik, Ole Paulsen, Alfonso Fairén, and Rafael Luján. “Expression and Distribution of Metabotropic GABA Receptor Subtypes GABABR1 and GABABR2 during Rat Neocortical Development.” <i>European Journal of Neuroscience</i>. Wiley-Blackwell, 2002. <a href=\"https://doi.org/10.1046/j.1460-9568.2002.02032.x\">https://doi.org/10.1046/j.1460-9568.2002.02032.x</a>.","ista":"López Bendito G, Shigemoto R, Kulik Á, Paulsen O, Fairén A, Luján R. 2002. Expression and distribution of metabotropic GABA receptor subtypes GABABR1 and GABABR2 during rat neocortical development. European Journal of Neuroscience. 15(11), 1766–1778.","ieee":"G. López Bendito, R. Shigemoto, Á. Kulik, O. Paulsen, A. Fairén, and R. Luján, “Expression and distribution of metabotropic GABA receptor subtypes GABABR1 and GABABR2 during rat neocortical development,” <i>European Journal of Neuroscience</i>, vol. 15, no. 11. Wiley-Blackwell, pp. 1766–1778, 2002.","ama":"López Bendito G, Shigemoto R, Kulik Á, Paulsen O, Fairén A, Luján R. Expression and distribution of metabotropic GABA receptor subtypes GABABR1 and GABABR2 during rat neocortical development. <i>European Journal of Neuroscience</i>. 2002;15(11):1766-1778. doi:<a href=\"https://doi.org/10.1046/j.1460-9568.2002.02032.x\">10.1046/j.1460-9568.2002.02032.x</a>","mla":"López Bendito, Guillermina, et al. “Expression and Distribution of Metabotropic GABA Receptor Subtypes GABABR1 and GABABR2 during Rat Neocortical Development.” <i>European Journal of Neuroscience</i>, vol. 15, no. 11, Wiley-Blackwell, 2002, pp. 1766–78, doi:<a href=\"https://doi.org/10.1046/j.1460-9568.2002.02032.x\">10.1046/j.1460-9568.2002.02032.x</a>.","apa":"López Bendito, G., Shigemoto, R., Kulik, Á., Paulsen, O., Fairén, A., &#38; Luján, R. (2002). Expression and distribution of metabotropic GABA receptor subtypes GABABR1 and GABABR2 during rat neocortical development. <i>European Journal of Neuroscience</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1046/j.1460-9568.2002.02032.x\">https://doi.org/10.1046/j.1460-9568.2002.02032.x</a>"},"abstract":[{"lang":"eng","text":"To understand the possible contribution of metabotropic γ-aminobutyric acid receptors (GABABR) in cortical development, we investigated the expression pattern and the cellular and subcellular localization of the GABABR1 and GABABR2 subtypes in the rat neocortex from embryonic day 14 (E14) to adulthood. At the light microscopic level, both GABABR1 and GABABR2 were detected as early as E14. During prenatal development, both subtypes were expressed highly in the cortical plate. Using double immunofluorescence, GABABR1 colocalized with GABABR2 in neurons of the marginal zone and subplate, indicating that these proteins are coexpressed and could be forming functional GABABRs during prenatal development in vivo. In contrast, only GABABR1 but not GABABR2 was detected in the tangentially migratory cells in the lower intermediate zone. During postnatal development, immunoreactivity for GABABR1 and GABABR2 was distributed mainly in pyramidal cells. Discrete GABABR1-immunopositive cell bodies of interneurons were present throughout the neocortex. In addition, GABABR1 but not GABABR2 was found in identified Cajal-Retzius cells in layer I. At the electron microscopic level, immunoreactivity for GABABR1 and GABABR2 was found in dendritic spines and dendritic shafts at extrasynaptic and perisynaptic sites throughout postnatal development. We further demonstrated the presynaptic localization of GABABR1 and GABABR2, as well as the association of the receptors with asymmetrical synaptic junctions. These results indicate potentially important roles for the GABABRs in the regulation of migratory processes during corticogenesis and in the modulation of synaptic transmission during early development of cortical circuitry."}],"publication_status":"published","_id":"2622","pmid":1,"publication":"European Journal of Neuroscience","title":"Expression and distribution of metabotropic GABA receptor subtypes GABABR1 and GABABR2 during rat neocortical development","page":"1766 - 1778","external_id":{"pmid":["12081656"]},"date_published":"2002-06-01T00:00:00Z","scopus_import":"1","publication_identifier":{"issn":["0953-816X"]},"day":"01","oa_version":"None","date_updated":"2023-07-19T07:30:39Z","type":"journal_article","article_processing_charge":"No","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","acknowledgement":"The authors are grateful to Dr Marco Sassoe-Pogneto for his comments on a previous version of the manuscript. We also would like to thank to Ms. Courtney Voelker for the English revision and comments of the manuscript. This work was made possible by grants from the European Community (QLG3-CT-1999–00192, R.L) and the Spanish Ministry of Science and Technology (PB97-0582-CO2-01, A.F).","doi":"10.1046/j.1460-9568.2002.02032.x","language":[{"iso":"eng"}]},{"type":"journal_article","date_updated":"2023-07-18T13:08:40Z","oa_version":"None","day":"01","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","acknowledgement":"This work was supported by research grants from the Ministry of Education, Science, Sports and Culture of Japan, and the Japan Society for the Promotion of Science (P96319). We thank Drs L. Zaborszky and R. Luján for their comments on the manuscript, Dr M. Watanabe for kindly supplying us with GluRδ2 and AMPA GluR1 antibodies, Dr R.E. Edwards for rabbit BNPI antibody, and J. Hatakeyama and S. Doi for technical assistance.","language":[{"iso":"eng"}],"doi":"10.1046/j.0953-816x.2001.01855.x","date_published":"2002-01-01T00:00:00Z","external_id":{"pmid":["11849296"]},"page":"291 - 307","publication_identifier":{"issn":["0953-816X"]},"scopus_import":"1","year":"2002","citation":{"mla":"Kulik, Ákos, et al. “Distinct Localization of GABAB Receptors Relative to Synaptic Sites in the Rat Cerebellum and Ventrobasal Thalamus.” <i>European Journal of Neuroscience</i>, vol. 15, no. 2, Wiley-Blackwell, 2002, pp. 291–307, doi:<a href=\"https://doi.org/10.1046/j.0953-816x.2001.01855.x\">10.1046/j.0953-816x.2001.01855.x</a>.","apa":"Kulik, Á., Nakadate, K., Nyíri, G., Notomi, T., Malitschek, B., Bettler, B., &#38; Shigemoto, R. (2002). Distinct localization of GABAB receptors relative to synaptic sites in the rat cerebellum and ventrobasal thalamus. <i>European Journal of Neuroscience</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1046/j.0953-816x.2001.01855.x\">https://doi.org/10.1046/j.0953-816x.2001.01855.x</a>","chicago":"Kulik, Ákos, Kazuhiko Nakadate, Gábor Nyíri, Takuya Notomi, Barbara Malitschek, Bernhard Bettler, and Ryuichi Shigemoto. “Distinct Localization of GABAB Receptors Relative to Synaptic Sites in the Rat Cerebellum and Ventrobasal Thalamus.” <i>European Journal of Neuroscience</i>. Wiley-Blackwell, 2002. <a href=\"https://doi.org/10.1046/j.0953-816x.2001.01855.x\">https://doi.org/10.1046/j.0953-816x.2001.01855.x</a>.","short":"Á. Kulik, K. Nakadate, G. Nyíri, T. Notomi, B. Malitschek, B. Bettler, R. Shigemoto, European Journal of Neuroscience 15 (2002) 291–307.","ista":"Kulik Á, Nakadate K, Nyíri G, Notomi T, Malitschek B, Bettler B, Shigemoto R. 2002. Distinct localization of GABAB receptors relative to synaptic sites in the rat cerebellum and ventrobasal thalamus. European Journal of Neuroscience. 15(2), 291–307.","ama":"Kulik Á, Nakadate K, Nyíri G, et al. Distinct localization of GABAB receptors relative to synaptic sites in the rat cerebellum and ventrobasal thalamus. <i>European Journal of Neuroscience</i>. 2002;15(2):291-307. doi:<a href=\"https://doi.org/10.1046/j.0953-816x.2001.01855.x\">10.1046/j.0953-816x.2001.01855.x</a>","ieee":"Á. Kulik <i>et al.</i>, “Distinct localization of GABAB receptors relative to synaptic sites in the rat cerebellum and ventrobasal thalamus,” <i>European Journal of Neuroscience</i>, vol. 15, no. 2. Wiley-Blackwell, pp. 291–307, 2002."},"extern":"1","author":[{"full_name":"Kulik, Ákos","last_name":"Kulik","first_name":"Ákos"},{"full_name":"Nakadate, Kazuhiko","last_name":"Nakadate","first_name":"Kazuhiko"},{"last_name":"Nyíri","first_name":"Gábor","full_name":"Nyíri, Gábor"},{"full_name":"Notomi, Takuya","last_name":"Notomi","first_name":"Takuya"},{"full_name":"Malitschek, Barbara","last_name":"Malitschek","first_name":"Barbara"},{"full_name":"Bettler, Bernhard","last_name":"Bettler","first_name":"Bernhard"},{"first_name":"Ryuichi","last_name":"Shigemoto","full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"}],"quality_controlled":"1","publication_status":"published","abstract":[{"lang":"eng","text":"Metabotropic γ-aminobutyric acid receptors (GABABRs) are involved in modulation of synaptic transmission and activity of cerebellar and thalamic neurons. We used subtype-specific antibodies in pre- and postembedding immunohistochemistry combined with three-dimensional reconstruction of labelled profiles and quantification of immunoparticles to reveal the subcellular distribution of pre- and postsynaptic GABABR1a/b and GABABR2 in the rat cerebellum and ventrobasal thalamus. GABABR1a/b and R2 were extensively colocalized in most brain regions including the cerebellum and thalamus. In the cerebellum, immunoreactivity for both subtypes was prevalent in the molecular layer. The most intense immunoreactivity was found in Purkinje cell spines with a high density of immunoparticles at extrasynaptic sites peaking at around 240 nm from glutamatergic synapses between spines and parallel fibre varicosities. This is in contrast to dendrites at sites around GABAergic synapses where sparse and random distribution was found for both subtypes. In addition, more than one-tenth of the synaptic membrane specialization of spine-parallel fibre synapses were labelled at pre- or postsynaptic sites. Weak immunolabelling for both subtypes was also seen in parallel fibres but only rarely in GABAergic axons. In the ventrobasal thalamus, immunolabelling for both receptor subtypes was intense over the dendritic field of thalamocortical cells. Electron microscopy demonstrated an extrasynaptic localization of GABABR1a/b and R2 exclusively in postsynaptic elements. Quantitative analysis further revealed the density of GABABR1a/b around GABAergic synapses was higher than glutamatergic synapses on thalamocortical cell dendrites. The distinct localization of GABABRs relative to synaptic sites in the cerebellum and ventrobasal thalamus suggests that GABABRs differentially regulate activity of different neuronal populations."}],"title":"Distinct localization of GABAB receptors relative to synaptic sites in the rat cerebellum and ventrobasal thalamus","publication":"European Journal of Neuroscience","pmid":1,"_id":"2624","publisher":"Wiley-Blackwell","article_type":"original","issue":"2","volume":15,"date_created":"2018-12-11T11:58:44Z","month":"01","status":"public","intvolume":"        15","publist_id":"4275"},{"status":"public","date_created":"2018-12-11T11:59:06Z","conference":{"name":"38th Winter School of Theoretical Physics : Dynamical Semigroups: Dissipation, Chaos, Quanta"},"month":"01","publication_identifier":{"isbn":["9783540441113"]},"publist_id":"4203","alternative_title":["LNP"],"publisher":"Springer","page":"487 - 506","date_published":"2002-01-01T00:00:00Z","publication_status":"published","abstract":[{"lang":"eng","text":"We outline the status of rigorous derivations of certain classical evolution equations as limits of Schrödinger dynamics. We explain two recent results jointly with H.T. Yau in more details. The first one is the derivation of the linear Boltzmann equation as the long time limit of the one-body Schrödinger equation with a random potential. The second one is the mean field limit of high density bosons with Coulomb interaction that leads to the nonlinear Hartree equation."}],"language":[{"iso":"eng"}],"doi":"10.1007/3-540-46122-1_19","_id":"2694","title":"Scaling limits of Schrödinger quantum mechanics","publication":"Dynamics of Dissipation","day":"01","year":"2002","date_updated":"2023-07-18T10:23:18Z","type":"book_chapter","series_title":"Lecture Notes in Physics","oa_version":"None","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","quality_controlled":"1","extern":"1","author":[{"last_name":"Erdös","first_name":"László","orcid":"0000-0001-5366-9603","full_name":"Erdös, László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87"}],"article_processing_charge":"No","citation":{"chicago":"Erdös, László. “Scaling Limits of Schrödinger Quantum Mechanics.” In <i>Dynamics of Dissipation</i>, 487–506. Lecture Notes in Physics. Springer, 2002. <a href=\"https://doi.org/10.1007/3-540-46122-1_19\">https://doi.org/10.1007/3-540-46122-1_19</a>.","short":"L. Erdös, in:, Dynamics of Dissipation, Springer, 2002, pp. 487–506.","ista":"Erdös L. 2002.Scaling limits of Schrödinger quantum mechanics. In: Dynamics of Dissipation. LNP, , 487–506.","ieee":"L. Erdös, “Scaling limits of Schrödinger quantum mechanics,” in <i>Dynamics of Dissipation</i>, Springer, 2002, pp. 487–506.","ama":"Erdös L. Scaling limits of Schrödinger quantum mechanics. In: <i>Dynamics of Dissipation</i>. Lecture Notes in Physics. Springer; 2002:487-506. doi:<a href=\"https://doi.org/10.1007/3-540-46122-1_19\">10.1007/3-540-46122-1_19</a>","apa":"Erdös, L. (2002). Scaling limits of Schrödinger quantum mechanics. In <i>Dynamics of Dissipation</i> (pp. 487–506). Springer. <a href=\"https://doi.org/10.1007/3-540-46122-1_19\">https://doi.org/10.1007/3-540-46122-1_19</a>","mla":"Erdös, László. “Scaling Limits of Schrödinger Quantum Mechanics.” <i>Dynamics of Dissipation</i>, Springer, 2002, pp. 487–506, doi:<a href=\"https://doi.org/10.1007/3-540-46122-1_19\">10.1007/3-540-46122-1_19</a>."}},{"extern":1,"quality_controlled":0,"author":[{"id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5366-9603","full_name":"László Erdös","last_name":"Erdös","first_name":"László"}],"citation":{"ieee":"L. Erdös, “Two dimensional Pauli operator via scalar potential,” presented at the QMath: Mathematical Results in Quantum Physics, 2002, vol. 307, pp. 129–133.","ama":"Erdös L. Two dimensional Pauli operator via scalar potential. In: Vol 307. World Scientific Publishing; 2002:129-133. doi:<a href=\"https://doi.org/10.1090/conm/307\">10.1090/conm/307</a>","short":"L. Erdös, in:, World Scientific Publishing, 2002, pp. 129–133.","chicago":"Erdös, László. “Two Dimensional Pauli Operator via Scalar Potential,” 307:129–33. World Scientific Publishing, 2002. <a href=\"https://doi.org/10.1090/conm/307\">https://doi.org/10.1090/conm/307</a>.","ista":"Erdös L. 2002. Two dimensional Pauli operator via scalar potential. QMath: Mathematical Results in Quantum Physics, Contemporary Mathematics, vol. 307, 129–133.","apa":"Erdös, L. (2002). Two dimensional Pauli operator via scalar potential (Vol. 307, pp. 129–133). Presented at the QMath: Mathematical Results in Quantum Physics, World Scientific Publishing. <a href=\"https://doi.org/10.1090/conm/307\">https://doi.org/10.1090/conm/307</a>","mla":"Erdös, László. <i>Two Dimensional Pauli Operator via Scalar Potential</i>. Vol. 307, World Scientific Publishing, 2002, pp. 129–33, doi:<a href=\"https://doi.org/10.1090/conm/307\">10.1090/conm/307</a>."},"day":"01","year":"2002","date_updated":"2021-01-12T06:59:11Z","type":"conference","doi":"10.1090/conm/307","_id":"2708","title":"Two dimensional Pauli operator via scalar potential","publication_status":"published","volume":307,"page":"129 - 133","date_published":"2002-01-01T00:00:00Z","publisher":"World Scientific Publishing","publist_id":"4188","intvolume":"       307","alternative_title":["Contemporary Mathematics"],"status":"public","date_created":"2018-12-11T11:59:11Z","conference":{"name":"QMath: Mathematical Results in Quantum Physics"},"month":"01"},{"status":"public","month":"03","date_created":"2018-12-11T11:59:20Z","publist_id":"4155","intvolume":"       334","publisher":"Elsevier","article_type":"original","volume":334,"issue":"6","abstract":[{"lang":"eng","text":"We derive the time-dependent Schrödinger–Poisson equation as the weak coupling limit of the N-body linear Schrödinger equation with Coulomb potential."}],"publication_status":"published","_id":"2737","publication":"Comptes Rendus Mathematique","title":"Derivation of the Schrödinger-Poisson equation from the quantum N-body problem","year":"2002","extern":"1","quality_controlled":"1","author":[{"first_name":"Claude","last_name":"Bardos","full_name":"Bardos, Claude"},{"id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5366-9603","full_name":"Erdös, László","last_name":"Erdös","first_name":"László"},{"last_name":"Golse","first_name":"François","full_name":"Golse, François"},{"first_name":"Norbert","last_name":"Mauser","full_name":"Mauser, Norbert"},{"full_name":"Yau, Horng","last_name":"Yau","first_name":"Horng"}],"citation":{"ista":"Bardos C, Erdös L, Golse F, Mauser N, Yau H. 2002. Derivation of the Schrödinger-Poisson equation from the quantum N-body problem. Comptes Rendus Mathematique. 334(6), 515–520.","chicago":"Bardos, Claude, László Erdös, François Golse, Norbert Mauser, and Horng Yau. “Derivation of the Schrödinger-Poisson Equation from the Quantum N-Body Problem.” <i>Comptes Rendus Mathematique</i>. Elsevier, 2002. <a href=\"https://doi.org/10.1016/S1631-073X(02)02253-7\">https://doi.org/10.1016/S1631-073X(02)02253-7</a>.","short":"C. Bardos, L. Erdös, F. Golse, N. Mauser, H. Yau, Comptes Rendus Mathematique 334 (2002) 515–520.","ama":"Bardos C, Erdös L, Golse F, Mauser N, Yau H. Derivation of the Schrödinger-Poisson equation from the quantum N-body problem. <i>Comptes Rendus Mathematique</i>. 2002;334(6):515-520. doi:<a href=\"https://doi.org/10.1016/S1631-073X(02)02253-7\">10.1016/S1631-073X(02)02253-7</a>","ieee":"C. Bardos, L. Erdös, F. Golse, N. Mauser, and H. Yau, “Derivation of the Schrödinger-Poisson equation from the quantum N-body problem,” <i>Comptes Rendus Mathematique</i>, vol. 334, no. 6. Elsevier, pp. 515–520, 2002.","apa":"Bardos, C., Erdös, L., Golse, F., Mauser, N., &#38; Yau, H. (2002). Derivation of the Schrödinger-Poisson equation from the quantum N-body problem. <i>Comptes Rendus Mathematique</i>. Elsevier. <a href=\"https://doi.org/10.1016/S1631-073X(02)02253-7\">https://doi.org/10.1016/S1631-073X(02)02253-7</a>","mla":"Bardos, Claude, et al. “Derivation of the Schrödinger-Poisson Equation from the Quantum N-Body Problem.” <i>Comptes Rendus Mathematique</i>, vol. 334, no. 6, Elsevier, 2002, pp. 515–20, doi:<a href=\"https://doi.org/10.1016/S1631-073X(02)02253-7\">10.1016/S1631-073X(02)02253-7</a>."},"scopus_import":"1","publication_identifier":{"issn":["1631-073X"]},"page":"515 - 520","date_published":"2002-03-30T00:00:00Z","acknowledgement":"The authors thank the ESI in Vienna and the Austrian START project “Nonlinear Schrödinger\r\nand quantum Boltzmann equations” of N.J.M. for hospitality and support. Also, F.G. was supported by the Institut\r\nUniversitaire de France and N.J.M. by the bilateral Austrian-French “AMADEUS” programme. H.-T.Y. and L.E. were\r\nsupported by NSF Grants DMS-0072098 and DMS-9970323, respectively","doi":"10.1016/S1631-073X(02)02253-7","language":[{"iso":"eng"}],"day":"30","oa_version":"None","type":"journal_article","date_updated":"2023-07-18T09:24:24Z","article_processing_charge":"No","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17"},{"page":"1043 - 1127","date_published":"2002-06-01T00:00:00Z","external_id":{"arxiv":["math-ph/0108025"]},"publication_identifier":{"issn":["0022-4715"]},"scopus_import":"1","arxiv":1,"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","day":"01","date_updated":"2023-07-18T09:08:45Z","type":"journal_article","oa_version":"Submitted Version","language":[{"iso":"eng"}],"doi":"10.1023/A:1015157624384","acknowledgement":"This work initially was a joint project with H.-T. Yau and several ideas\r\npresented here have been developed in collaboration with him. I would like\r\nto thank him for the invaluable discussions and encouragement through\r\nthe entire work. Part of this project was completed during several visits at\r\nthe Erwin Schrödinger Institute, Vienna, and at the Center of Theoretical\r\nStudies, Hsinchu, Taiwan. The author is grateful for the hospitality and\r\nfinancial support. This work was partially supported by NSF Grant DMS9970323.","issue":"5-6","volume":107,"publisher":"Springer","article_type":"original","publist_id":"4154","intvolume":"       107","status":"public","date_created":"2018-12-11T11:59:20Z","month":"06","quality_controlled":"1","author":[{"last_name":"Erdös","first_name":"László","full_name":"Erdös, László","orcid":"0000-0001-5366-9603","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87"}],"extern":"1","citation":{"ista":"Erdös L. 2002. Linear Boltzmann equation as the long time dynamics of an electron weakly coupled to a phonon field. Journal of Statistical Physics. 107(5–6), 1043–1127.","short":"L. Erdös, Journal of Statistical Physics 107 (2002) 1043–1127.","chicago":"Erdös, László. “Linear Boltzmann Equation as the Long Time Dynamics of an Electron Weakly Coupled to a Phonon Field.” <i>Journal of Statistical Physics</i>. Springer, 2002. <a href=\"https://doi.org/10.1023/A:1015157624384\">https://doi.org/10.1023/A:1015157624384</a>.","ama":"Erdös L. Linear Boltzmann equation as the long time dynamics of an electron weakly coupled to a phonon field. <i>Journal of Statistical Physics</i>. 2002;107(5-6):1043-1127. doi:<a href=\"https://doi.org/10.1023/A:1015157624384\">10.1023/A:1015157624384</a>","ieee":"L. Erdös, “Linear Boltzmann equation as the long time dynamics of an electron weakly coupled to a phonon field,” <i>Journal of Statistical Physics</i>, vol. 107, no. 5–6. Springer, pp. 1043–1127, 2002.","mla":"Erdös, László. “Linear Boltzmann Equation as the Long Time Dynamics of an Electron Weakly Coupled to a Phonon Field.” <i>Journal of Statistical Physics</i>, vol. 107, no. 5–6, Springer, 2002, pp. 1043–127, doi:<a href=\"https://doi.org/10.1023/A:1015157624384\">10.1023/A:1015157624384</a>.","apa":"Erdös, L. (2002). Linear Boltzmann equation as the long time dynamics of an electron weakly coupled to a phonon field. <i>Journal of Statistical Physics</i>. Springer. <a href=\"https://doi.org/10.1023/A:1015157624384\">https://doi.org/10.1023/A:1015157624384</a>"},"year":"2002","_id":"2738","title":"Linear Boltzmann equation as the long time dynamics of an electron weakly coupled to a phonon field","publication":"Journal of Statistical Physics","publication_status":"published","abstract":[{"lang":"eng","text":"We consider the long time evolution of a quantum particle weakly interacting with a phonon field. We show that in the weak coupling limit the Wigner distribution of the electron density matrix converges to the solution of the linear Boltzmann equation globally in time. The collision kernel is identified as the sum of an emission and an absorption term that depend on the equilibrium distribution of the free phonon modes."}]},{"date_published":"2002-02-01T00:00:00Z","external_id":{"arxiv":["math-ph/0109015v1"]},"page":"399 - 421","publication_identifier":{"issn":["0010-3616"]},"scopus_import":"1","arxiv":1,"article_processing_charge":"No","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_updated":"2023-07-18T08:57:54Z","type":"journal_article","oa_version":"None","day":"01","doi":"10.1007/s002200100585","language":[{"iso":"eng"}],"acknowledgement":"This work started during the first author’s visit at the Erwin Schrödinger Institute, Vienna.\r\nValuable discussions with T. Hoffmann-Ostenhof and M. Loss are gratefully acknowledged. The authors thank\r\nthe referee for careful reading and comments","issue":"2","volume":225,"article_type":"original","publisher":"Springer","intvolume":"       225","publist_id":"4153","date_created":"2018-12-11T11:59:21Z","month":"02","status":"public","citation":{"ista":"Erdös L, Vougalter V. 2002. Pauli operator and Aharonov–Casher theorem¶ for measure valued magnetic fields. Communications in Mathematical Physics. 225(2), 399–421.","chicago":"Erdös, László, and Vitali Vougalter. “Pauli Operator and Aharonov–Casher Theorem¶ for Measure Valued Magnetic Fields.” <i>Communications in Mathematical Physics</i>. Springer, 2002. <a href=\"https://doi.org/10.1007/s002200100585\">https://doi.org/10.1007/s002200100585</a>.","short":"L. Erdös, V. Vougalter, Communications in Mathematical Physics 225 (2002) 399–421.","ieee":"L. Erdös and V. Vougalter, “Pauli operator and Aharonov–Casher theorem¶ for measure valued magnetic fields,” <i>Communications in Mathematical Physics</i>, vol. 225, no. 2. Springer, pp. 399–421, 2002.","ama":"Erdös L, Vougalter V. Pauli operator and Aharonov–Casher theorem¶ for measure valued magnetic fields. <i>Communications in Mathematical Physics</i>. 2002;225(2):399-421. doi:<a href=\"https://doi.org/10.1007/s002200100585\">10.1007/s002200100585</a>","mla":"Erdös, László, and Vitali Vougalter. “Pauli Operator and Aharonov–Casher Theorem¶ for Measure Valued Magnetic Fields.” <i>Communications in Mathematical Physics</i>, vol. 225, no. 2, Springer, 2002, pp. 399–421, doi:<a href=\"https://doi.org/10.1007/s002200100585\">10.1007/s002200100585</a>.","apa":"Erdös, L., &#38; Vougalter, V. (2002). Pauli operator and Aharonov–Casher theorem¶ for measure valued magnetic fields. <i>Communications in Mathematical Physics</i>. Springer. <a href=\"https://doi.org/10.1007/s002200100585\">https://doi.org/10.1007/s002200100585</a>"},"extern":"1","quality_controlled":"1","author":[{"first_name":"László","last_name":"Erdös","orcid":"0000-0001-5366-9603","full_name":"Erdös, László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Vitali","last_name":"Vougalter","full_name":"Vougalter, Vitali"}],"year":"2002","publication":"Communications in Mathematical Physics","title":"Pauli operator and Aharonov–Casher theorem¶ for measure valued magnetic fields","_id":"2739","publication_status":"published","abstract":[{"text":"We define the two dimensional Pauli operator and identify its core for magnetic fields that are regular Borel measures. The magnetic field is generated by a scalar potential hence we bypass the usual A L 2loc condition on the vector potential, which does not allow to consider such singular fields. We extend the Aharonov-Casher theorem for magnetic fields that are measures with finite total variation and we present a counterexample in case of infinite total variation. One of the key technical tools is a weighted L 2 estimate on a singular integral operator.","lang":"eng"}]},{"year":"2002","citation":{"ista":"Erdös L. 2002. Spectral shift and multiplicity of the first eigenvalue of the magnetic Schrödinger operator in two dimensions. Annales de l’Institut Fourier. 52(6), 1833–1874.","chicago":"Erdös, László. “Spectral Shift and Multiplicity of the First Eigenvalue of the Magnetic Schrödinger Operator in Two Dimensions.” <i>Annales de l’Institut Fourier</i>. Association des Annales de l’Institut Fourier, 2002. <a href=\"https://doi.org/10.5802/aif.1936\">https://doi.org/10.5802/aif.1936</a>.","short":"L. Erdös, Annales de l’Institut Fourier 52 (2002) 1833–1874.","ieee":"L. Erdös, “Spectral shift and multiplicity of the first eigenvalue of the magnetic Schrödinger operator in two dimensions,” <i>Annales de l’Institut Fourier</i>, vol. 52, no. 6. Association des Annales de l’Institut Fourier, pp. 1833–1874, 2002.","ama":"Erdös L. Spectral shift and multiplicity of the first eigenvalue of the magnetic Schrödinger operator in two dimensions. <i>Annales de l’Institut Fourier</i>. 2002;52(6):1833-1874. doi:<a href=\"https://doi.org/10.5802/aif.1936\">10.5802/aif.1936</a>","apa":"Erdös, L. (2002). Spectral shift and multiplicity of the first eigenvalue of the magnetic Schrödinger operator in two dimensions. <i>Annales de l’Institut Fourier</i>. Association des Annales de l’Institut Fourier. <a href=\"https://doi.org/10.5802/aif.1936\">https://doi.org/10.5802/aif.1936</a>","mla":"Erdös, László. “Spectral Shift and Multiplicity of the First Eigenvalue of the Magnetic Schrödinger Operator in Two Dimensions.” <i>Annales de l’Institut Fourier</i>, vol. 52, no. 6, Association des Annales de l’Institut Fourier, 2002, pp. 1833–74, doi:<a href=\"https://doi.org/10.5802/aif.1936\">10.5802/aif.1936</a>."},"quality_controlled":"1","extern":"1","author":[{"full_name":"Erdös, László","orcid":"0000-0001-5366-9603","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","last_name":"Erdös","first_name":"László"}],"abstract":[{"lang":"eng","text":"We show that the lowest eigenvalue of the magnetic Schrödinger operator on a line bundle over a compact Riemann surface M is bounded by the L1-norm of the magnetic field B. This implies a similar bound on the multiplicity of the ground state. An example shows that this degeneracy can indeed be comparable with ∫M |B| even in case of the trivial bundle."}],"publication_status":"published","title":"Spectral shift and multiplicity of the first eigenvalue of the magnetic Schrödinger operator in two dimensions","publication":"Annales de l'Institut Fourier","_id":"2740","article_type":"original","publisher":"Association des Annales de l'Institut Fourier","issue":"6","volume":52,"month":"01","date_created":"2018-12-11T11:59:21Z","status":"public","intvolume":"        52","publist_id":"4152","oa_version":"None","type":"journal_article","date_updated":"2023-07-18T08:38:34Z","day":"01","article_processing_charge":"No","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","doi":"10.5802/aif.1936","language":[{"iso":"eng"}],"date_published":"2002-01-01T00:00:00Z","page":"1833-1874","scopus_import":"1","publication_identifier":{"issn":["0373-0956"]}},{"abstract":[{"lang":"eng","text":"Developmental responses to the plant hormone auxin are thought to be mediated by interacting pairs from two protein families: short-lived inhibitory IAA proteins and ARF transcription factors binding to auxin-response elements. Monopteros mutants lacking activating ARF5 and the auxin-insensitive mutant bodenlos fail to initiate the root meristem during early embryogenesis. Here we show that the bodenlos phenotype results from an amino-acid exchange in the conserved degradation domain of IAA12. BODENLOS and MONOPTEROS interact in the yeast two-hybrid assay and the two genes are coexpressed in early embryogenesis, suggesting that BODENLOS inhibits MONOPTEROS action in root meristem initiation."}],"publication_status":"published","pmid":1,"publication":"Genes and Development","title":"The Arabidopsis BODENLOS gene encodes an auxin response protein inhibiting MONOPTEROS-mediated embryo patterning","_id":"2866","oa":1,"year":"2002","main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC186366/"}],"citation":{"ama":"Hamann T, Benková E, Bäurle I, Kientz M, Jürgens G. The Arabidopsis BODENLOS gene encodes an auxin response protein inhibiting MONOPTEROS-mediated embryo patterning. <i>Genes and Development</i>. 2002;16(13):1610-1615. doi:<a href=\"https://doi.org/10.1101/gad.229402\">10.1101/gad.229402</a>","ieee":"T. Hamann, E. Benková, I. Bäurle, M. Kientz, and G. Jürgens, “The Arabidopsis BODENLOS gene encodes an auxin response protein inhibiting MONOPTEROS-mediated embryo patterning,” <i>Genes and Development</i>, vol. 16, no. 13. Cold Spring Harbor Laboratory Press, pp. 1610–1615, 2002.","ista":"Hamann T, Benková E, Bäurle I, Kientz M, Jürgens G. 2002. The Arabidopsis BODENLOS gene encodes an auxin response protein inhibiting MONOPTEROS-mediated embryo patterning. Genes and Development. 16(13), 1610–1615.","short":"T. Hamann, E. Benková, I. Bäurle, M. Kientz, G. Jürgens, Genes and Development 16 (2002) 1610–1615.","chicago":"Hamann, Thorsten, Eva Benková, Isabel Bäurle, Marika Kientz, and Gerd Jürgens. “The Arabidopsis BODENLOS Gene Encodes an Auxin Response Protein Inhibiting MONOPTEROS-Mediated Embryo Patterning.” <i>Genes and Development</i>. Cold Spring Harbor Laboratory Press, 2002. <a href=\"https://doi.org/10.1101/gad.229402\">https://doi.org/10.1101/gad.229402</a>.","mla":"Hamann, Thorsten, et al. “The Arabidopsis BODENLOS Gene Encodes an Auxin Response Protein Inhibiting MONOPTEROS-Mediated Embryo Patterning.” <i>Genes and Development</i>, vol. 16, no. 13, Cold Spring Harbor Laboratory Press, 2002, pp. 1610–15, doi:<a href=\"https://doi.org/10.1101/gad.229402\">10.1101/gad.229402</a>.","apa":"Hamann, T., Benková, E., Bäurle, I., Kientz, M., &#38; Jürgens, G. (2002). The Arabidopsis BODENLOS gene encodes an auxin response protein inhibiting MONOPTEROS-mediated embryo patterning. <i>Genes and Development</i>. Cold Spring Harbor Laboratory Press. <a href=\"https://doi.org/10.1101/gad.229402\">https://doi.org/10.1101/gad.229402</a>"},"extern":"1","author":[{"full_name":"Hamann, Thorsten","first_name":"Thorsten","last_name":"Hamann"},{"id":"38F4F166-F248-11E8-B48F-1D18A9856A87","full_name":"Benková, Eva","orcid":"0000-0002-8510-9739","first_name":"Eva","last_name":"Benková"},{"full_name":"Bäurle, Isabel","first_name":"Isabel","last_name":"Bäurle"},{"full_name":"Kientz, Marika","last_name":"Kientz","first_name":"Marika"},{"first_name":"Gerd","last_name":"Jürgens","full_name":"Jürgens, Gerd"}],"quality_controlled":"1","month":"07","date_created":"2018-12-11T12:00:01Z","status":"public","intvolume":"        16","publist_id":"3921","publisher":"Cold Spring Harbor Laboratory Press","article_type":"original","issue":"13","volume":16,"acknowledgement":"We thank C. Maulbetsch for isolating BDL cDNA clones; T. Berleth and J. Friml for providing clones for in situ probes; K. Harter for making available the parsley protoplast system; and J. Friml, N. Geldner, M. Griffith, C. Schwechheimer, D. Weigel, and D. Weijers for helpful comments and critical reading of the manuscript. This work was supported by Sonderforschungsbereich 446 “Mechanismen des Zellverhaltens bei Eukaryoten.”\r\n\r\nThe publication costs of this article were defrayed in part by payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 USC section 1734 solely to indicate this fact.","language":[{"iso":"eng"}],"doi":"10.1101/gad.229402","oa_version":"Published Version","type":"journal_article","date_updated":"2023-07-18T08:26:58Z","day":"01","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","scopus_import":"1","publication_identifier":{"issn":["0890-9369"]},"external_id":{"pmid":["12101120"]},"date_published":"2002-07-01T00:00:00Z","page":"1610 - 1615"},{"publisher":"Springer","page":"65 - 81","date_published":"2002-01-01T00:00:00Z","status":"public","date_created":"2018-12-11T12:00:23Z","month":"01","conference":{"start_date":"2002-05-28","location":"Copenhagen, Denmark","end_date":"2002-05-31","name":"ECCV: European Conference on Computer Vision"},"publist_id":"3810","publication_identifier":{"isbn":["9783540437468"]},"scopus_import":"1","day":"01","year":"2002","type":"conference","date_updated":"2023-07-18T08:20:02Z","oa_version":"None","article_processing_charge":"No","quality_controlled":"1","author":[{"id":"3D50B0BA-F248-11E8-B48F-1D18A9856A87","full_name":"Kolmogorov, Vladimir","first_name":"Vladimir","last_name":"Kolmogorov"},{"full_name":"Zabih, Ramin","first_name":"Ramin","last_name":"Zabih"}],"extern":"1","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","citation":{"ieee":"V. Kolmogorov and R. Zabih, “Multi-camera scene reconstruction via graph cuts,” in <i>Proceedings of the 7th European Conference on Computer Vision</i>, Copenhagen, Denmark, 2002, pp. 65–81.","ama":"Kolmogorov V, Zabih R. Multi-camera scene reconstruction via graph cuts. In: <i>Proceedings of the 7th European Conference on Computer Vision</i>. Springer; 2002:65-81. doi:<a href=\"https://doi.org/10.1007/3-540-47977-5_5\">10.1007/3-540-47977-5_5</a>","ista":"Kolmogorov V, Zabih R. 2002. Multi-camera scene reconstruction via graph cuts. Proceedings of the 7th European Conference on Computer Vision. ECCV: European Conference on Computer Vision, 65–81.","chicago":"Kolmogorov, Vladimir, and Ramin Zabih. “Multi-Camera Scene Reconstruction via Graph Cuts.” In <i>Proceedings of the 7th European Conference on Computer Vision</i>, 65–81. Springer, 2002. <a href=\"https://doi.org/10.1007/3-540-47977-5_5\">https://doi.org/10.1007/3-540-47977-5_5</a>.","short":"V. Kolmogorov, R. Zabih, in:, Proceedings of the 7th European Conference on Computer Vision, Springer, 2002, pp. 65–81.","mla":"Kolmogorov, Vladimir, and Ramin Zabih. “Multi-Camera Scene Reconstruction via Graph Cuts.” <i>Proceedings of the 7th European Conference on Computer Vision</i>, Springer, 2002, pp. 65–81, doi:<a href=\"https://doi.org/10.1007/3-540-47977-5_5\">10.1007/3-540-47977-5_5</a>.","apa":"Kolmogorov, V., &#38; Zabih, R. (2002). Multi-camera scene reconstruction via graph cuts. In <i>Proceedings of the 7th European Conference on Computer Vision</i> (pp. 65–81). Copenhagen, Denmark: Springer. <a href=\"https://doi.org/10.1007/3-540-47977-5_5\">https://doi.org/10.1007/3-540-47977-5_5</a>"},"publication_status":"published","abstract":[{"lang":"eng","text":"In the last few years, several new algorithms based on graph cuts have been developed to solve energy minimization problems in computer vision. Each of these techniques constructs a graph such that the minimum cut on the graph also minimizes the energy. Yet because these graph constructions are complex and highly specific to a particular energy function, graph cuts have seen limited application to date. In this paper we characterize the energy functions that can be minimized by graph cuts. Our results are restricted to energy functions with binary variables. However, our work generalizes many previous constructions, and is easily applicable to vision problems that involve large numbers of labels, such as stereo, motion, image restoration and scene reconstruction. We present three main results: a necessary condition for any energy function that can be minimized by graph cuts; a sufficient condition for energy functions that can be written as a sum of functions of up to three variables at a time; and a general-purpose construction to minimize such an energy function. Researchers who are considering the use of graph cuts to optimize a particular energy function can use our results to determine if this is possible, and then follow our construction to create the appropriate graph."}],"acknowledgement":"We thank Olga Veksler and Yuri Boykov for their careful reading of this paper, and for valuable comments which greatly improved itsreadibility. We also thank Ian Jermyn for helping us clarify the paper’s motivation. This research was supported by NSF grants IIS-9900115 and CCR-0113371, and by a grant from Microsoft Research.","language":[{"iso":"eng"}],"doi":"10.1007/3-540-47977-5_5","_id":"2927","title":"Multi-camera scene reconstruction via graph cuts","publication":"Proceedings of the 7th European Conference on Computer Vision"},{"publication_identifier":{"issn":["0028-0836"]},"scopus_import":"1","date_published":"2002-02-14T00:00:00Z","external_id":{"pmid":["11845211 "]},"page":"806 - 809","language":[{"iso":"eng"}],"doi":"10.1038/415806a","acknowledgement":"We thank G. Jürgens for enabling J.F. to accomplish part of this work in his laboratory; P. Tänzler and M. Sauer for technical assistance; H. Vahlenkamp for technical assistance in immunocytochemistry; M. Estelle for providing material and suggestions; T. Altman for BAC filter sets; the ADIS (Automated DNA Isolation and Sequencing) service group for DNA sequencing; ZIGIA (Center for Functional Genomics in Arabidopsis) for the En lines; and N. Geldner, T. Hamann, G. Jürgens, K. Schrick and C. Schwechheimer for comments and critical reading of the manuscript. This work was supported by a fellowship of the DAAD (J.F.), the DFG (Schwerpunktprogramm Phytohormone), the Fonds der chemischen Industrie, the European Communities Biotechnology Programs, the INCO-Copernicus Program and the European Space Agency MAP-Biotechnology Programme","article_processing_charge":"No","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_updated":"2023-07-18T07:30:27Z","type":"journal_article","oa_version":"None","day":"14","intvolume":"       415","publist_id":"3715","date_created":"2018-12-11T12:00:42Z","month":"02","status":"public","volume":415,"issue":"6873","article_type":"original","publisher":"Nature Publishing Group","title":"Lateral relocation of auxin efflux regulator PIN3 mediates tropism in Arabidopsis","publication":"Nature","pmid":1,"_id":"2986","publication_status":"published","abstract":[{"lang":"eng","text":"Long-standing models propose that plant growth responses to light or gravity are mediated by asymmetric distribution of the phytohormone auxin. Physiological studies implicated a specific transport system that relocates auxin laterally, thereby effecting differential growth; however, neither the molecular components of this system nor the cellular mechanism of auxin redistribution on light or gravity perception have been identified. Here, we show that auxin accumulates asymmetrically during differential growth in an efflux-dependent manner. Mutations in the Arabidopsis gene PIN3, a regulator of auxin efflux, alter differential growth. PIN3 is expressed in gravity-sensing tissues, with PIN3 protein accumulating predominantly at the lateral cell surface. PIN3 localizes to the plasma membrane and to vesicles that cycle in an actin-dependent manner. In the root columella, PIN3 is positioned symmetrically at the plasma membrane but rapidly relocalizes laterally on gravity stimulation. Our data indicate that PIN3 is a component of the lateral auxin transport system regulating tropic growth. In addition, actin-dependent relocalization of PIN3 in response to gravity provides a mechanism for redirecting auxin flux to trigger asymmetric growth."}],"citation":{"mla":"Friml, Jiří, et al. “Lateral Relocation of Auxin Efflux Regulator PIN3 Mediates Tropism in Arabidopsis.” <i>Nature</i>, vol. 415, no. 6873, Nature Publishing Group, 2002, pp. 806–09, doi:<a href=\"https://doi.org/10.1038/415806a\">10.1038/415806a</a>.","apa":"Friml, J., Wiśniewska, J., Benková, E., Mendgen, K., &#38; Palme, K. (2002). Lateral relocation of auxin efflux regulator PIN3 mediates tropism in Arabidopsis. <i>Nature</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/415806a\">https://doi.org/10.1038/415806a</a>","ieee":"J. Friml, J. Wiśniewska, E. Benková, K. Mendgen, and K. Palme, “Lateral relocation of auxin efflux regulator PIN3 mediates tropism in Arabidopsis,” <i>Nature</i>, vol. 415, no. 6873. Nature Publishing Group, pp. 806–809, 2002.","ama":"Friml J, Wiśniewska J, Benková E, Mendgen K, Palme K. Lateral relocation of auxin efflux regulator PIN3 mediates tropism in Arabidopsis. <i>Nature</i>. 2002;415(6873):806-809. doi:<a href=\"https://doi.org/10.1038/415806a\">10.1038/415806a</a>","short":"J. Friml, J. Wiśniewska, E. Benková, K. Mendgen, K. Palme, Nature 415 (2002) 806–809.","chicago":"Friml, Jiří, Justyna Wiśniewska, Eva Benková, Kurt Mendgen, and Klaus Palme. “Lateral Relocation of Auxin Efflux Regulator PIN3 Mediates Tropism in Arabidopsis.” <i>Nature</i>. Nature Publishing Group, 2002. <a href=\"https://doi.org/10.1038/415806a\">https://doi.org/10.1038/415806a</a>.","ista":"Friml J, Wiśniewska J, Benková E, Mendgen K, Palme K. 2002. Lateral relocation of auxin efflux regulator PIN3 mediates tropism in Arabidopsis. Nature. 415(6873), 806–809."},"extern":"1","author":[{"last_name":"Friml","first_name":"Jirí","full_name":"Friml, Jirí","orcid":"0000-0002-8302-7596","id":"4159519E-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Justyna","last_name":"Wiśniewska","full_name":"Wiśniewska, Justyna"},{"id":"38F4F166-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8510-9739","full_name":"Benková, Eva","first_name":"Eva","last_name":"Benková"},{"last_name":"Mendgen","first_name":"Kurt","full_name":"Mendgen, Kurt"},{"first_name":"Klaus","last_name":"Palme","full_name":"Palme, Klaus"}],"quality_controlled":"1","year":"2002"},{"status":"public","date_created":"2018-12-11T12:00:42Z","month":"05","publist_id":"3716","intvolume":"        14","article_type":"original","publisher":"American Society of Plant Biologists","volume":14,"issue":"5","publication_status":"published","abstract":[{"text":"The hydra mutants of Arabidopsis are characterized by a pleiotropic phenotype that shows defective embryonic and seedling cell patterning, morphogenesis, and root growth. We demonstrate that the HYDRA1 gene encodes a Δ8-Δ7 sterol isomerase, whereas HYDRA2 encodes a sterol C14 reductase, previously identified as the FACKEL gene product. Seedlings mutant for each gene are similarly defective in the concentrations of the three major Arabidopsis sterols. Promoter::reporter gene analysis showed misexpression of the auxin-regulated DR5 and ACS1 promoters and of the epidermal cell file-specific GL2 promoter in the mutants. The mutants exhibit enhanced responses to auxin. The phenotypes can be rescued partially by inhibition of auxin and ethylene signaling but not by exogenous sterols or brassinosteroids. We propose a model in which correct sterol profiles are required for regulated auxin and ethylene signaling through effects on membrane function.","lang":"eng"}],"oa":1,"_id":"2987","publication":"Plant Cell","title":"Hydra mutants of Arabidopsis are defective in sterol profiles and auxin and ethylene signaling","pmid":1,"year":"2002","extern":"1","quality_controlled":"1","author":[{"full_name":"Souter, Martin","first_name":"Martin","last_name":"Souter"},{"last_name":"Topping","first_name":"Jennifer","full_name":"Topping, Jennifer"},{"last_name":"Pullen","first_name":"Margaret","full_name":"Pullen, Margaret"},{"full_name":"Friml, Jirí","orcid":"0000-0002-8302-7596","id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml","first_name":"Jirí"},{"last_name":"Palme","first_name":"Klaus","full_name":"Palme, Klaus"},{"full_name":"Hackett, Rachel","first_name":"Rachel","last_name":"Hackett"},{"last_name":"Grierson","first_name":"Don","full_name":"Grierson, Don"},{"full_name":"Lindsey, Keith","last_name":"Lindsey","first_name":"Keith"}],"citation":{"mla":"Souter, Martin, et al. “Hydra Mutants of Arabidopsis Are Defective in Sterol Profiles and Auxin and Ethylene Signaling.” <i>Plant Cell</i>, vol. 14, no. 5, American Society of Plant Biologists, 2002, pp. 1017–31, doi:<a href=\"https://doi.org/10.1105/tpc.001248\">10.1105/tpc.001248</a>.","apa":"Souter, M., Topping, J., Pullen, M., Friml, J., Palme, K., Hackett, R., … Lindsey, K. (2002). Hydra mutants of Arabidopsis are defective in sterol profiles and auxin and ethylene signaling. <i>Plant Cell</i>. American Society of Plant Biologists. <a href=\"https://doi.org/10.1105/tpc.001248\">https://doi.org/10.1105/tpc.001248</a>","ieee":"M. Souter <i>et al.</i>, “Hydra mutants of Arabidopsis are defective in sterol profiles and auxin and ethylene signaling,” <i>Plant Cell</i>, vol. 14, no. 5. American Society of Plant Biologists, pp. 1017–1031, 2002.","ama":"Souter M, Topping J, Pullen M, et al. Hydra mutants of Arabidopsis are defective in sterol profiles and auxin and ethylene signaling. <i>Plant Cell</i>. 2002;14(5):1017-1031. doi:<a href=\"https://doi.org/10.1105/tpc.001248\">10.1105/tpc.001248</a>","ista":"Souter M, Topping J, Pullen M, Friml J, Palme K, Hackett R, Grierson D, Lindsey K. 2002. Hydra mutants of Arabidopsis are defective in sterol profiles and auxin and ethylene signaling. Plant Cell. 14(5), 1017–1031.","short":"M. Souter, J. Topping, M. Pullen, J. Friml, K. Palme, R. Hackett, D. Grierson, K. Lindsey, Plant Cell 14 (2002) 1017–1031.","chicago":"Souter, Martin, Jennifer Topping, Margaret Pullen, Jiří Friml, Klaus Palme, Rachel Hackett, Don Grierson, and Keith Lindsey. “Hydra Mutants of Arabidopsis Are Defective in Sterol Profiles and Auxin and Ethylene Signaling.” <i>Plant Cell</i>. American Society of Plant Biologists, 2002. <a href=\"https://doi.org/10.1105/tpc.001248\">https://doi.org/10.1105/tpc.001248</a>."},"main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC150604/","open_access":"1"}],"publication_identifier":{"issn":["1040-4651"]},"scopus_import":"1","page":"1017 - 1031","date_published":"2002-05-01T00:00:00Z","external_id":{"pmid":["12034894"]},"acknowledgement":"We thank Dr. Ken Feldmann for providing prospective hyd alleles, Dr. Jane Murfett for providing DR5::GUS seed, Dr. D. Van Der Straeten for providing ACS1::GUS seed, Dr. John Schiefelbein for providing GL2::GFP seed, and Dr. Ottoline Leyser for axr1-12 and axr3-1 seed. etr1 and fk seed was obtained from the Nottingham Arabidopsis Stock Centre. This work was supported by a Biotechnology and Biological Science Research Council research studentship to M.S., a Durham University studentship to M.P., and Biotechnology and Biological Science Research Council Grant 12/P02330 to J.T.","doi":"10.1105/tpc.001248","language":[{"iso":"eng"}],"day":"01","type":"journal_article","date_updated":"2023-07-18T07:34:32Z","oa_version":"None","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No"},{"intvolume":"        12","publist_id":"3714","date_created":"2018-12-11T12:00:43Z","month":"02","status":"public","issue":"4","volume":12,"article_type":"original","publisher":"Cell Press","title":"Cell polarity signaling in Arabidopsis involves a BFA sensitive auxin influx pathway","publication":"Current Biology","pmid":1,"_id":"2988","publication_status":"published","abstract":[{"text":"Coordination of cell and tissue polarity commonly involves directional signaling [1]. In the Arabidopsis root epidermis, cell polarity is revealed by basal, root tip-oriented, hair outgrowth from hair-forming cells (trichoblasts) [2]. The plant hormone auxin displays polar movements [1, 3] and accumulates at maximum concentration in the root tip [4, 5]. The application of polar auxin transport inhibitors [3] evokes changes in trichoblast polarity only at high concentrations and after long-term application [2, 4]. Thus, it remains open whether components of the auxin transport machinery mediate establishment of trichoblast polarity. Here we report that the presumptive auxin influx carrier AUX1 [6, 7] contributes to apical-basal hair cell polarity. AUX1 function is required for polarity changes induced by exogenous application of the auxin 2,4-D, a preferential influx carrier substrate. Similar to aux1 mutants, the vesicle trafficking inhibitor brefeldin A (BFA) interferes with polar hair initiation, and AUX1 function is required for BFA-mediated polarity changes. Consistently, BFA inhibits membrane trafficking of AUX1, trichoblast hyperpolarization induced by 2,4-D, and alters the distal auxin maximum. Our results identify AUX1 as one component of a novel BFA-sensitive auxin transport pathway polarizing cells toward a hormone maximum.","lang":"eng"}],"citation":{"ieee":"M. Grebe <i>et al.</i>, “Cell polarity signaling in Arabidopsis involves a BFA sensitive auxin influx pathway,” <i>Current Biology</i>, vol. 12, no. 4. Cell Press, pp. 329–334, 2002.","ama":"Grebe M, Friml J, Swarup R, et al. Cell polarity signaling in Arabidopsis involves a BFA sensitive auxin influx pathway. <i>Current Biology</i>. 2002;12(4):329-334. doi:<a href=\"https://doi.org/10.1016/S0960-9822(02)00654-1\">10.1016/S0960-9822(02)00654-1</a>","chicago":"Grebe, Markus, Jiří Friml, Ranjan Swarup, Karin Ljung, Göran Sandberg, Maarten Terlou, Klaus Palme, Malcolm Bennett, and Ben Scheres. “Cell Polarity Signaling in Arabidopsis Involves a BFA Sensitive Auxin Influx Pathway.” <i>Current Biology</i>. Cell Press, 2002. <a href=\"https://doi.org/10.1016/S0960-9822(02)00654-1\">https://doi.org/10.1016/S0960-9822(02)00654-1</a>.","short":"M. Grebe, J. Friml, R. Swarup, K. Ljung, G. Sandberg, M. Terlou, K. Palme, M. Bennett, B. Scheres, Current Biology 12 (2002) 329–334.","ista":"Grebe M, Friml J, Swarup R, Ljung K, Sandberg G, Terlou M, Palme K, Bennett M, Scheres B. 2002. Cell polarity signaling in Arabidopsis involves a BFA sensitive auxin influx pathway. Current Biology. 12(4), 329–334.","apa":"Grebe, M., Friml, J., Swarup, R., Ljung, K., Sandberg, G., Terlou, M., … Scheres, B. (2002). Cell polarity signaling in Arabidopsis involves a BFA sensitive auxin influx pathway. <i>Current Biology</i>. Cell Press. <a href=\"https://doi.org/10.1016/S0960-9822(02)00654-1\">https://doi.org/10.1016/S0960-9822(02)00654-1</a>","mla":"Grebe, Markus, et al. “Cell Polarity Signaling in Arabidopsis Involves a BFA Sensitive Auxin Influx Pathway.” <i>Current Biology</i>, vol. 12, no. 4, Cell Press, 2002, pp. 329–34, doi:<a href=\"https://doi.org/10.1016/S0960-9822(02)00654-1\">10.1016/S0960-9822(02)00654-1</a>."},"extern":"1","author":[{"first_name":"Markus","last_name":"Grebe","full_name":"Grebe, Markus"},{"full_name":"Friml, Jirí","orcid":"0000-0002-8302-7596","id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml","first_name":"Jirí"},{"full_name":"Swarup, Ranjan","last_name":"Swarup","first_name":"Ranjan"},{"last_name":"Ljung","first_name":"Karin","full_name":"Ljung, Karin"},{"full_name":"Sandberg, Göran","last_name":"Sandberg","first_name":"Göran"},{"full_name":"Terlou, Maarten","last_name":"Terlou","first_name":"Maarten"},{"first_name":"Klaus","last_name":"Palme","full_name":"Palme, Klaus"},{"full_name":"Bennett, Malcolm","first_name":"Malcolm","last_name":"Bennett"},{"first_name":"Ben","last_name":"Scheres","full_name":"Scheres, Ben"}],"quality_controlled":"1","year":"2002","publication_identifier":{"issn":["0960-9822"]},"scopus_import":"1","date_published":"2002-02-19T00:00:00Z","external_id":{"pmid":["11864575"]},"page":"329 - 334","doi":"10.1016/S0960-9822(02)00654-1","language":[{"iso":"eng"}],"article_processing_charge":"No","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","type":"journal_article","date_updated":"2023-07-17T12:15:28Z","oa_version":"None","day":"19"},{"doi":"10.1016/S0092-8674(02)00656-6","language":[{"iso":"eng"}],"acknowledgement":"We thank Petra Tänzler, Michaela Lehnen, and Thomas Steinmann for technical help. We acknowledge the Arabidopsis Biological Resource Center (Columbus, OH) and Thomas Altman for providing material. We also gratefully acknowledge the ADIS service group for DNA sequencing and ZIGIA (Center for Functional Genomics in Arabidopsis) for the En lines. We are grateful to our colleagues, particularly Leo Gälweiler, Niko Geldner, Matthias Godde, and Kathrin Schrick for critical reading of the manuscript. This work was supported by a fellowship of the Deutscher Akademischer Austauschdienset (J.F.), the Deutsche Forschungsgemeinschaft (Schwerpunktprogramm Phytohormone), the European Communities Biotechnology Programs, the Fonds der Chemischen Industrie, and the INCO-Copernicus Program.","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","day":"08","type":"journal_article","date_updated":"2023-07-17T11:57:40Z","oa_version":"None","publication_identifier":{"issn":["0092-8674"]},"scopus_import":"1","page":"661 - 673","date_published":"2002-03-08T00:00:00Z","external_id":{"pmid":["11893337"]},"_id":"2989","title":"AtPIN4 mediates sink-driven auxin gradients and root patterning in Arabidopsis","publication":"Cell","pmid":1,"publication_status":"published","abstract":[{"text":"In contrast to animals, little is known about pattern formation in plants. Physiological and genetic data suggest the involvement of the phytohormone auxin in this process. Here, we characterize a novel member of the PIN family of putative auxin efflux carriers, Arabidopsis PIN4, that is localized in developing and mature root meristems. Atpin4 mutants are defective in establishment and maintenance of endogenous auxin gradients, fail to canalize externally applied auxin, and display various patterning defects in both embryonic and seedling roots. We propose a role for AtPIN4 in generating a sink for auxin below the quiescent center of the root meristem that is essential for auxin distribution and patterning.","lang":"eng"}],"author":[{"id":"4159519E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8302-7596","full_name":"Friml, Jirí","last_name":"Friml","first_name":"Jirí"},{"last_name":"Benková","first_name":"Eva","id":"38F4F166-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8510-9739","full_name":"Benková, Eva"},{"full_name":"Blilou, Ikram","first_name":"Ikram","last_name":"Blilou"},{"first_name":"Justyna","last_name":"Wiśniewska","full_name":"Wiśniewska, Justyna"},{"last_name":"Hamann","first_name":"Thorsten","full_name":"Hamann, Thorsten"},{"last_name":"Ljung","first_name":"Karin","full_name":"Ljung, Karin"},{"full_name":"Woody, Scott","first_name":"Scott","last_name":"Woody"},{"first_name":"Göran","last_name":"Sandberg","full_name":"Sandberg, Göran"},{"first_name":"Ben","last_name":"Scheres","full_name":"Scheres, Ben"},{"full_name":"Jürgens, Gerd","last_name":"Jürgens","first_name":"Gerd"},{"first_name":"Klaus","last_name":"Palme","full_name":"Palme, Klaus"}],"quality_controlled":"1","extern":"1","citation":{"ieee":"J. Friml <i>et al.</i>, “AtPIN4 mediates sink-driven auxin gradients and root patterning in Arabidopsis,” <i>Cell</i>, vol. 108, no. 5. Cell Press, pp. 661–673, 2002.","ama":"Friml J, Benková E, Blilou I, et al. AtPIN4 mediates sink-driven auxin gradients and root patterning in Arabidopsis. <i>Cell</i>. 2002;108(5):661-673. doi:<a href=\"https://doi.org/10.1016/S0092-8674(02)00656-6\">10.1016/S0092-8674(02)00656-6</a>","chicago":"Friml, Jiří, Eva Benková, Ikram Blilou, Justyna Wiśniewska, Thorsten Hamann, Karin Ljung, Scott Woody, et al. “AtPIN4 Mediates Sink-Driven Auxin Gradients and Root Patterning in Arabidopsis.” <i>Cell</i>. Cell Press, 2002. <a href=\"https://doi.org/10.1016/S0092-8674(02)00656-6\">https://doi.org/10.1016/S0092-8674(02)00656-6</a>.","short":"J. Friml, E. Benková, I. Blilou, J. Wiśniewska, T. Hamann, K. Ljung, S. Woody, G. Sandberg, B. Scheres, G. Jürgens, K. Palme, Cell 108 (2002) 661–673.","ista":"Friml J, Benková E, Blilou I, Wiśniewska J, Hamann T, Ljung K, Woody S, Sandberg G, Scheres B, Jürgens G, Palme K. 2002. AtPIN4 mediates sink-driven auxin gradients and root patterning in Arabidopsis. Cell. 108(5), 661–673.","mla":"Friml, Jiří, et al. “AtPIN4 Mediates Sink-Driven Auxin Gradients and Root Patterning in Arabidopsis.” <i>Cell</i>, vol. 108, no. 5, Cell Press, 2002, pp. 661–73, doi:<a href=\"https://doi.org/10.1016/S0092-8674(02)00656-6\">10.1016/S0092-8674(02)00656-6</a>.","apa":"Friml, J., Benková, E., Blilou, I., Wiśniewska, J., Hamann, T., Ljung, K., … Palme, K. (2002). AtPIN4 mediates sink-driven auxin gradients and root patterning in Arabidopsis. <i>Cell</i>. Cell Press. <a href=\"https://doi.org/10.1016/S0092-8674(02)00656-6\">https://doi.org/10.1016/S0092-8674(02)00656-6</a>"},"year":"2002","publist_id":"3713","intvolume":"       108","status":"public","date_created":"2018-12-11T12:00:43Z","month":"03","volume":108,"issue":"5","article_type":"original","publisher":"Cell Press"},{"date_published":"2002-06-01T00:00:00Z","page":"273 - 284","volume":49,"issue":"3-4","publisher":"Springer","intvolume":"        49","publist_id":"3712","date_created":"2018-12-11T12:00:44Z","month":"06","status":"public","citation":{"ama":"Friml J, Palme K. Polar auxin transport - Old questions and new concepts? <i>Plant Molecular Biology</i>. 2002;49(3-4):273-284. doi:<a href=\"https://doi.org/10.1023/A:1015248926412\">10.1023/A:1015248926412</a>","ieee":"J. Friml and K. Palme, “Polar auxin transport - Old questions and new concepts?,” <i>Plant Molecular Biology</i>, vol. 49, no. 3–4. Springer, pp. 273–284, 2002.","ista":"Friml J, Palme K. 2002. Polar auxin transport - Old questions and new concepts? Plant Molecular Biology. 49(3–4), 273–284.","short":"J. Friml, K. Palme, Plant Molecular Biology 49 (2002) 273–284.","chicago":"Friml, Jiří, and Klaus Palme. “Polar Auxin Transport - Old Questions and New Concepts?” <i>Plant Molecular Biology</i>. Springer, 2002. <a href=\"https://doi.org/10.1023/A:1015248926412\">https://doi.org/10.1023/A:1015248926412</a>.","apa":"Friml, J., &#38; Palme, K. (2002). Polar auxin transport - Old questions and new concepts? <i>Plant Molecular Biology</i>. Springer. <a href=\"https://doi.org/10.1023/A:1015248926412\">https://doi.org/10.1023/A:1015248926412</a>","mla":"Friml, Jiří, and Klaus Palme. “Polar Auxin Transport - Old Questions and New Concepts?” <i>Plant Molecular Biology</i>, vol. 49, no. 3–4, Springer, 2002, pp. 273–84, doi:<a href=\"https://doi.org/10.1023/A:1015248926412\">10.1023/A:1015248926412</a>."},"user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","quality_controlled":"1","extern":"1","author":[{"last_name":"Friml","first_name":"Jirí","full_name":"Friml, Jirí","orcid":"0000-0002-8302-7596","id":"4159519E-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Palme","first_name":"Klaus","full_name":"Palme, Klaus"}],"date_updated":"2021-01-12T07:40:17Z","type":"journal_article","oa_version":"None","day":"01","year":"2002","title":"Polar auxin transport - Old questions and new concepts?","publication":"Plant Molecular Biology","doi":"10.1023/A:1015248926412","language":[{"iso":"eng"}],"_id":"2991","publication_status":"published","abstract":[{"lang":"eng","text":"Polar auxin transport controls multiple aspects of plant development including differential growth, embryo and root patterning and vascular tissue differentiation. Identification of proteins involved in this process and availability of new tools enabling `visualization' of auxin and auxin routes in planta largely contributed to the significant progress that has recently been made. New data support classical concepts, but several recent findings are likely to challenge our view on the mechanism of auxin transport. The aim of this review is to provide a comprehensive overview of the polar auxin transport field. It starts with classical models resulting from physiological studies, describes the genetic contributions and discusses the molecular basis of auxin influx and efflux. Finally, selected questions are presented in the context of developmental biology, integrating available data from different fields."}]},{"year":"2002","citation":{"ista":"Hippenmeyer S, Shneider N, Birchmeier C, Burden S, Jessell T, Arber S. 2002. A role for Neuregulin1 signaling in muscle spindle differentiation. Neuron. 36(6), 1035–1049.","chicago":"Hippenmeyer, Simon, Neil Shneider, Carmen Birchmeier, Steven Burden, Thomas Jessell, and Silvia Arber. “A Role for Neuregulin1 Signaling in Muscle Spindle Differentiation.” <i>Neuron</i>. Elsevier, 2002. <a href=\"https://doi.org/10.1016/S0896-6273(02)01101-7\">https://doi.org/10.1016/S0896-6273(02)01101-7</a>.","short":"S. Hippenmeyer, N. Shneider, C. Birchmeier, S. Burden, T. Jessell, S. Arber, Neuron 36 (2002) 1035–1049.","ieee":"S. Hippenmeyer, N. Shneider, C. Birchmeier, S. Burden, T. Jessell, and S. Arber, “A role for Neuregulin1 signaling in muscle spindle differentiation,” <i>Neuron</i>, vol. 36, no. 6. Elsevier, pp. 1035–1049, 2002.","ama":"Hippenmeyer S, Shneider N, Birchmeier C, Burden S, Jessell T, Arber S. A role for Neuregulin1 signaling in muscle spindle differentiation. <i>Neuron</i>. 2002;36(6):1035-1049. doi:<a href=\"https://doi.org/10.1016/S0896-6273(02)01101-7\">10.1016/S0896-6273(02)01101-7</a>","mla":"Hippenmeyer, Simon, et al. “A Role for Neuregulin1 Signaling in Muscle Spindle Differentiation.” <i>Neuron</i>, vol. 36, no. 6, Elsevier, 2002, pp. 1035–49, doi:<a href=\"https://doi.org/10.1016/S0896-6273(02)01101-7\">10.1016/S0896-6273(02)01101-7</a>.","apa":"Hippenmeyer, S., Shneider, N., Birchmeier, C., Burden, S., Jessell, T., &#38; Arber, S. (2002). A role for Neuregulin1 signaling in muscle spindle differentiation. <i>Neuron</i>. Elsevier. <a href=\"https://doi.org/10.1016/S0896-6273(02)01101-7\">https://doi.org/10.1016/S0896-6273(02)01101-7</a>"},"extern":"1","quality_controlled":"1","author":[{"full_name":"Hippenmeyer, Simon","orcid":"0000-0003-2279-1061","id":"37B36620-F248-11E8-B48F-1D18A9856A87","last_name":"Hippenmeyer","first_name":"Simon"},{"first_name":"Neil","last_name":"Shneider","full_name":"Shneider, Neil"},{"full_name":"Birchmeier, Carmen","last_name":"Birchmeier","first_name":"Carmen"},{"full_name":"Burden, Steven","last_name":"Burden","first_name":"Steven"},{"full_name":"Jessell, Thomas","last_name":"Jessell","first_name":"Thomas"},{"first_name":"Silvia","last_name":"Arber","full_name":"Arber, Silvia"}],"abstract":[{"text":"The maturation of synaptic structures depends on inductive interactions between axons and their prospective targets. One example of such an interaction is the influence of proprioceptive sensory axons on the differentiation of muscle spindles. We have monitored the expression of three transcription factors, Egr3, Pea3, and Erm, that delineate early muscle spindle development in an assay of muscle spindle-inducing signals. We provide genetic evidence that Neuregulin1 (Nrg1) is required for proprioceptive afferent-evoked induction of muscle spindle differentiation in the mouse. Ig-Nrg1 isoforms are preferentially expressed by proprioceptive sensory neurons and are sufficient to induce muscle spindle differentiation in vivo, whereas CRD-Nrg1 isoforms are broadly expressed in sensory and motor neurons but are not required for muscle spindle induction.","lang":"eng"}],"publication_status":"published","pmid":1,"title":"A role for Neuregulin1 signaling in muscle spindle differentiation","publication":"Neuron","_id":"3140","article_type":"original","publisher":"Elsevier","volume":36,"issue":"6","month":"12","date_created":"2018-12-11T12:01:37Z","status":"public","intvolume":"        36","publist_id":"3558","oa_version":"None","date_updated":"2023-07-17T11:46:43Z","type":"journal_article","day":"19","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","acknowledgement":"We thank L. Role for generously providing the CRD-Nrg1 mutant allele for these studies, L. Parada and D. Anderson for sharing the TrkC and Ngn1 mouse strains, W. Tourtellotte for providing Egr3 mutant mice, E. Avetisova for expert technical assistance, X. Yang for experimental help in the initial phase of these studies, A. Garratt for advice with ErbB antibodies, and L. Role and G. Fischbach for helpful discussions. The CRD-Nrg1 mutant allele was generated in the lab of Dr. Lorna Role, with the support of NIH grant NS29071. S.A. and S.H. were supported by a grant from the Swiss National Science Foundation and the Kanton of Basel-Stadt. S.J.B. was supported by grants from the NINDS. N.A.S. was supported by a Howard Hughes Medical Institute Postdoctoral Fellowship for Physicians and a Career Development Award from the NINDS. T.M.J. was supported by grants from NINDS and is an Investigator of the Howard Hughes Medical Institute.","doi":"10.1016/S0896-6273(02)01101-7","language":[{"iso":"eng"}],"external_id":{"pmid":["12495620"]},"date_published":"2002-12-19T00:00:00Z","page":"1035 - 1049","scopus_import":"1","publication_identifier":{"issn":["0896-6273"]}}]