[{"intvolume":"       429","publist_id":"2401","publication":"Nature","date_created":"2018-12-11T12:05:17Z","_id":"3809","type":"journal_article","year":"2004","status":"public","day":"01","doi":"10.1038/nature02553","page":"184 - 7","abstract":[{"lang":"eng","text":"Neural stem cells in various regions of the vertebrate brain continuously generate neurons throughout life. In the mammalian hippocampus, a region important for spatial and episodic memory, thousands of new granule cells are produced per day, with the exact number depending on environmental conditions and physical exercise. The survival of these neurons is improved by learning and conversely learning may be promoted by neurogenesis. Although it has been suggested that newly generated neurons may have specific properties to facilitate learning, the cellular and synaptic mechanisms of plasticity in these neurons are largely unknown. Here we show that young granule cells in the adult hippocampus differ substantially from mature granule cells in both active and passive membrane properties. In young neurons, T-type Ca2+ channels can generate isolated Ca2+ spikes and boost fast Na+ action potentials, contributing to the induction of synaptic plasticity. Associative long-term potentiation can be induced more easily in young neurons than in mature neurons under identical conditions. Thus, newly generated neurons express unique mechanisms to facilitate synaptic plasticity, which may be important for the formation of new memories."}],"month":"01","publication_status":"published","issue":"6988","date_published":"2004-01-01T00:00:00Z","publisher":"Nature Publishing Group","title":"Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus","volume":429,"date_updated":"2021-01-12T07:52:21Z","quality_controlled":0,"extern":1,"citation":{"apa":"Schmidt Hieber, C., Jonas, P. M., &#38; Bischofberger, J. (2004). Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus. <i>Nature</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/nature02553\">https://doi.org/10.1038/nature02553</a>","ista":"Schmidt Hieber C, Jonas PM, Bischofberger J. 2004. Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus. Nature. 429(6988), 184–7.","ama":"Schmidt Hieber C, Jonas PM, Bischofberger J. Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus. <i>Nature</i>. 2004;429(6988):184-187. doi:<a href=\"https://doi.org/10.1038/nature02553\">10.1038/nature02553</a>","chicago":"Schmidt Hieber, Christoph, Peter M Jonas, and Josef Bischofberger. “Enhanced Synaptic Plasticity in Newly Generated Granule Cells of the Adult Hippocampus.” <i>Nature</i>. Nature Publishing Group, 2004. <a href=\"https://doi.org/10.1038/nature02553\">https://doi.org/10.1038/nature02553</a>.","ieee":"C. Schmidt Hieber, P. M. Jonas, and J. Bischofberger, “Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus,” <i>Nature</i>, vol. 429, no. 6988. Nature Publishing Group, pp. 184–7, 2004.","short":"C. Schmidt Hieber, P.M. Jonas, J. Bischofberger, Nature 429 (2004) 184–7.","mla":"Schmidt Hieber, Christoph, et al. “Enhanced Synaptic Plasticity in Newly Generated Granule Cells of the Adult Hippocampus.” <i>Nature</i>, vol. 429, no. 6988, Nature Publishing Group, 2004, pp. 184–87, doi:<a href=\"https://doi.org/10.1038/nature02553\">10.1038/nature02553</a>."},"author":[{"last_name":"Schmidt Hieber","first_name":"Christoph","full_name":"Schmidt-Hieber, Christoph"},{"last_name":"Jonas","first_name":"Peter M","orcid":"0000-0001-5001-4804","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","full_name":"Peter Jonas"},{"full_name":"Bischofberger, Josef","last_name":"Bischofberger","first_name":"Josef"}]},{"publist_id":"2402","intvolume":"       304","publication":"Science","date_created":"2018-12-11T12:05:18Z","type":"journal_article","_id":"3810","doi":"10.1126/science.1094113","year":"2004","day":"01","status":"public","page":"265 - 70","publication_status":"published","month":"01","abstract":[{"text":"Voltage-gated potassium (Kv) channels control action potential repolarization, interspike membrane potential, and action potential frequency in excitable cells. It is thought that the combinatorial association between distinct alpha and beta subunits determines whether Kv channels function as non-inactivating delayed rectifiers or as rapidly inactivating A-type channels. We show that membrane lipids can convert A-type channels into delayed rectifiers and vice versa. Phosphoinositides remove N-type inactivation from A-type channels by immobilizing the inactivation domains. Conversely, arachidonic acid and its amide anandamide endow delayed rectifiers with rapid voltage-dependent inactivation. The bidirectional control of Kv channel gating by lipids may provide a mechanism for the dynamic regulation of electrical signaling in the nervous system.","lang":"eng"}],"issue":"5668","date_published":"2004-01-01T00:00:00Z","publisher":"American Association for the Advancement of Science","title":"Functional conversion between A-type and delayed rectifier K+ channels by membrane lipids","volume":304,"quality_controlled":0,"extern":1,"date_updated":"2021-01-12T07:52:22Z","citation":{"ieee":"D. Oliver, C. Lien, M. Soom, T. Baukrowitz, P. M. Jonas, and B. Fakler, “Functional conversion between A-type and delayed rectifier K+ channels by membrane lipids,” <i>Science</i>, vol. 304, no. 5668. American Association for the Advancement of Science, pp. 265–70, 2004.","chicago":"Oliver, Dominik, Cheng Lien, Malle Soom, Thomas Baukrowitz, Peter M Jonas, and Bernd Fakler. “Functional Conversion between A-Type and Delayed Rectifier K+ Channels by Membrane Lipids.” <i>Science</i>. American Association for the Advancement of Science, 2004. <a href=\"https://doi.org/10.1126/science.1094113\">https://doi.org/10.1126/science.1094113</a>.","ama":"Oliver D, Lien C, Soom M, Baukrowitz T, Jonas PM, Fakler B. Functional conversion between A-type and delayed rectifier K+ channels by membrane lipids. <i>Science</i>. 2004;304(5668):265-270. doi:<a href=\"https://doi.org/10.1126/science.1094113\">10.1126/science.1094113</a>","ista":"Oliver D, Lien C, Soom M, Baukrowitz T, Jonas PM, Fakler B. 2004. Functional conversion between A-type and delayed rectifier K+ channels by membrane lipids. Science. 304(5668), 265–70.","apa":"Oliver, D., Lien, C., Soom, M., Baukrowitz, T., Jonas, P. M., &#38; Fakler, B. (2004). Functional conversion between A-type and delayed rectifier K+ channels by membrane lipids. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1094113\">https://doi.org/10.1126/science.1094113</a>","mla":"Oliver, Dominik, et al. “Functional Conversion between A-Type and Delayed Rectifier K+ Channels by Membrane Lipids.” <i>Science</i>, vol. 304, no. 5668, American Association for the Advancement of Science, 2004, pp. 265–70, doi:<a href=\"https://doi.org/10.1126/science.1094113\">10.1126/science.1094113</a>.","short":"D. Oliver, C. Lien, M. Soom, T. Baukrowitz, P.M. Jonas, B. Fakler, Science 304 (2004) 265–70."},"author":[{"first_name":"Dominik","last_name":"Oliver","full_name":"Oliver, Dominik"},{"last_name":"Lien","first_name":"Cheng","full_name":"Lien, Cheng-Chang"},{"full_name":"Soom, Malle","last_name":"Soom","first_name":"Malle"},{"last_name":"Baukrowitz","first_name":"Thomas","full_name":"Baukrowitz, Thomas"},{"full_name":"Peter Jonas","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5001-4804","last_name":"Jonas","first_name":"Peter M"},{"last_name":"Fakler","first_name":"Bernd","full_name":"Fakler, Bernd"}]},{"date_published":"2004-09-09T00:00:00Z","publisher":"Springer","title":"On Nash equilibria in stochastic games","volume":3210,"abstract":[{"text":"We study infinite stochastic games played by n-players on a finite graph with goals given by sets of infinite traces. The games are stochastic (each player simultaneously and independently chooses an action at each round, and the next state is determined by a probability distribution depending on the current state and the chosen actions), infinite (the game continues for an infinite number of rounds), nonzero sum (the players' goals are not necessarily conflicting), and undiscounted. We show that if each player has a reachability objective, that is, if the goal for each player i is to visit some subset R-i of the states, then there exists an epsilon-Nash equilibrium in memoryless strategies, for every epsilon &gt; 0. However, exact Nash equilibria need not exist. We study the complexity of finding such Nash equilibria, and show that the payoff of some epsilon-Nash equilibrium in memoryless strategies can be epsilon-approximated in NP. We study the important subclass of n-player turn-based probabilistic games, where at each state at most one player has a nontrivial choice of moves. For turn-based probabilistic games, we show the existence of epsilon-Nash equilibria in pure strategies for games where the objective of player i is a Borel set B-i of infinite traces. However, exact Nash equilibria may not exist. For the special case of omega-regular objectives, we show exact Nash equilibria exist, and can be computed in NP when the omega-regular objectives are expressed as parity objectives.","lang":"eng"}],"publication_status":"published","month":"09","author":[{"full_name":"Krishnendu Chatterjee","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4561-241X","first_name":"Krishnendu","last_name":"Chatterjee"},{"full_name":"Majumdar, Ritankar S","first_name":"Ritankar","last_name":"Majumdar"},{"last_name":"Jurdziński","first_name":"Marcin","full_name":"Jurdziński, Marcin"}],"alternative_title":["LNCS "],"date_updated":"2021-01-12T07:53:01Z","extern":1,"quality_controlled":0,"citation":{"short":"K. Chatterjee, R. Majumdar, M. Jurdziński, in:, Springer, 2004, pp. 26–40.","mla":"Chatterjee, Krishnendu, et al. <i>On Nash Equilibria in Stochastic Games</i>. Vol. 3210, Springer, 2004, pp. 26–40, doi:<a href=\"https://doi.org/10.1007/978-3-540-30124-0_6\">10.1007/978-3-540-30124-0_6</a>.","ieee":"K. Chatterjee, R. Majumdar, and M. Jurdziński, “On Nash equilibria in stochastic games,” presented at the CSL: Computer Science Logic, 2004, vol. 3210, pp. 26–40.","apa":"Chatterjee, K., Majumdar, R., &#38; Jurdziński, M. (2004). On Nash equilibria in stochastic games (Vol. 3210, pp. 26–40). Presented at the CSL: Computer Science Logic, Springer. <a href=\"https://doi.org/10.1007/978-3-540-30124-0_6\">https://doi.org/10.1007/978-3-540-30124-0_6</a>","chicago":"Chatterjee, Krishnendu, Ritankar Majumdar, and Marcin Jurdziński. “On Nash Equilibria in Stochastic Games,” 3210:26–40. Springer, 2004. <a href=\"https://doi.org/10.1007/978-3-540-30124-0_6\">https://doi.org/10.1007/978-3-540-30124-0_6</a>.","ista":"Chatterjee K, Majumdar R, Jurdziński M. 2004. On Nash equilibria in stochastic games. CSL: Computer Science Logic, LNCS , vol. 3210, 26–40.","ama":"Chatterjee K, Majumdar R, Jurdziński M. On Nash equilibria in stochastic games. In: Vol 3210. Springer; 2004:26-40. doi:<a href=\"https://doi.org/10.1007/978-3-540-30124-0_6\">10.1007/978-3-540-30124-0_6</a>"},"intvolume":"      3210","publist_id":"2264","conference":{"name":"CSL: Computer Science Logic"},"acknowledgement":"This research was supported in part by the AFOSR MURI grant F49620-00-1-0327, ONR grant N00014-02-1-0671, NSF grants CCR-9988172 and CCR-0225610","page":"26 - 40","doi":"10.1007/978-3-540-30124-0_6","status":"public","day":"09","year":"2004","date_created":"2018-12-11T12:05:45Z","type":"conference","_id":"3894"},{"citation":{"short":"K. Chatterjee, T.A. Henzinger, M. Jurdziński, in:, IEEE, 2004, pp. 160–169.","mla":"Chatterjee, Krishnendu, et al. <i>Games with Secure Equilibria</i>. IEEE, 2004, pp. 160–69, doi:<a href=\"https://doi.org/10.1109/LICS.2004.1319610\">10.1109/LICS.2004.1319610</a>.","apa":"Chatterjee, K., Henzinger, T. A., &#38; Jurdziński, M. (2004). Games with secure equilibria (pp. 160–169). Presented at the LICS: Logic in Computer Science, IEEE. <a href=\"https://doi.org/10.1109/LICS.2004.1319610\">https://doi.org/10.1109/LICS.2004.1319610</a>","ista":"Chatterjee K, Henzinger TA, Jurdziński M. 2004. Games with secure equilibria. LICS: Logic in Computer Science, 160–169.","chicago":"Chatterjee, Krishnendu, Thomas A Henzinger, and Marcin Jurdziński. “Games with Secure Equilibria,” 160–69. IEEE, 2004. <a href=\"https://doi.org/10.1109/LICS.2004.1319610\">https://doi.org/10.1109/LICS.2004.1319610</a>.","ama":"Chatterjee K, Henzinger TA, Jurdziński M. Games with secure equilibria. In: IEEE; 2004:160-169. doi:<a href=\"https://doi.org/10.1109/LICS.2004.1319610\">10.1109/LICS.2004.1319610</a>","ieee":"K. Chatterjee, T. A. Henzinger, and M. Jurdziński, “Games with secure equilibria,” presented at the LICS: Logic in Computer Science, 2004, pp. 160–169."},"quality_controlled":0,"extern":1,"date_updated":"2021-01-12T07:53:01Z","author":[{"orcid":"0000-0002-4561-241X","first_name":"Krishnendu","last_name":"Chatterjee","full_name":"Krishnendu Chatterjee","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000−0002−2985−7724","last_name":"Henzinger","first_name":"Thomas A","full_name":"Thomas Henzinger","id":"40876CD8-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Marcin","last_name":"Jurdziński","full_name":"Jurdziński, Marcin"}],"publication_status":"published","month":"08","abstract":[{"text":"In 2-player non-zero-sum games, Nash equilibria capture the options for rational behavior if each player attempts to maximize her payoff. In contrast to classical game theory, we consider lexicographic objectives: first, each player tries to maximize her own payoff, and then, the player tries to minimize the opponent's payoff. Such objectives arise naturally in the verification of systems with multiple components. There, instead of proving that each component satisfies its specification no matter how the other components behave, it often suffices to prove that each component satisfies its specification provided that the other components satisfy their specifications. We say that a Nash equilibrium is secure if it is an equilibrium with respect to the lexicographic objectives of both players. We prove that in graph games with Borel objectives, which include the games that arise in verification, there may be several Nash equilibria, but there is always a unique maximal payoff profile of secure equilibria. We show how this equilibrium can be computed in the case of omega-regular objectives, and we characterize the memory requirements of strategies that achieve the equilibrium.","lang":"eng"}],"title":"Games with secure equilibria","publisher":"IEEE","date_published":"2004-08-09T00:00:00Z","_id":"3895","type":"conference","date_created":"2018-12-11T12:05:45Z","doi":"10.1109/LICS.2004.1319610","day":"09","year":"2004","status":"public","page":"160 - 169","conference":{"name":"LICS: Logic in Computer Science"},"publist_id":"2262"},{"type":"journal_article","_id":"3918","date_created":"2018-12-11T12:05:53Z","year":"2004","page":"275 - 278","doi":"10.1007/s00040-004-0740-6","status":"public","day":"19","publication":"Insectes Sociaux","publist_id":"2236","intvolume":"        51","oa_version":"None","citation":{"ista":"Heinze J, Böttcher A, Cremer S. 2004. Production of winged and wingless males in the ant, Cardiocondyla minutior. Insectes Sociaux. 51(3), 275–278.","chicago":"Heinze, Jürgen, A. Böttcher, and Sylvia Cremer. “Production of Winged and Wingless Males in the Ant, Cardiocondyla Minutior.” <i>Insectes Sociaux</i>. Springer, 2004. <a href=\"https://doi.org/10.1007/s00040-004-0740-6\">https://doi.org/10.1007/s00040-004-0740-6</a>.","ama":"Heinze J, Böttcher A, Cremer S. Production of winged and wingless males in the ant, Cardiocondyla minutior. <i>Insectes Sociaux</i>. 2004;51(3):275-278. doi:<a href=\"https://doi.org/10.1007/s00040-004-0740-6\">10.1007/s00040-004-0740-6</a>","apa":"Heinze, J., Böttcher, A., &#38; Cremer, S. (2004). Production of winged and wingless males in the ant, Cardiocondyla minutior. <i>Insectes Sociaux</i>. Springer. <a href=\"https://doi.org/10.1007/s00040-004-0740-6\">https://doi.org/10.1007/s00040-004-0740-6</a>","ieee":"J. Heinze, A. Böttcher, and S. Cremer, “Production of winged and wingless males in the ant, Cardiocondyla minutior,” <i>Insectes Sociaux</i>, vol. 51, no. 3. Springer, pp. 275–278, 2004.","short":"J. Heinze, A. Böttcher, S. Cremer, Insectes Sociaux 51 (2004) 275–278.","mla":"Heinze, Jürgen, et al. “Production of Winged and Wingless Males in the Ant, Cardiocondyla Minutior.” <i>Insectes Sociaux</i>, vol. 51, no. 3, Springer, 2004, pp. 275–78, doi:<a href=\"https://doi.org/10.1007/s00040-004-0740-6\">10.1007/s00040-004-0740-6</a>."},"extern":"1","date_updated":"2021-01-12T07:53:11Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"full_name":"Heinze, Jürgen","first_name":"Jürgen","last_name":"Heinze"},{"full_name":"Böttcher, A.","last_name":"Böttcher","first_name":"A."},{"id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","full_name":"Cremer, Sylvia","first_name":"Sylvia","last_name":"Cremer","orcid":"0000-0002-2193-3868"}],"issue":"3","month":"08","publication_status":"published","abstract":[{"text":"Wingless (ergatoid) males of the tramp ant Cardiocondyla minutior attack and kill their young ergatoid rivals and thus attempt to monopolize mating with female sexuals reared in the colony. Because of the different strength of local mate competition in colonies with one or several reproductive queens, we expected the production of new ergatoid males to vary with queen number. Sex ratios were mostly female-biased, but in contrast to the sympatric species C. obscurior (Cremer and Heinze, 2002) neither the percentage of ergatoid males nor of female sexuals among the first 20 sexuals produced varied considerably with queen number. As in C. obscurior, experimental colony fragmentation led to the production of winged males, whereas in unfragmented control colonies only ergatoid males eclosed.","lang":"eng"}],"title":"Production of winged and wingless males in the ant, Cardiocondyla minutior","volume":51,"date_published":"2004-08-19T00:00:00Z","language":[{"iso":"eng"}],"publisher":"Springer"},{"author":[{"full_name":"Witte, Vanessa","last_name":"Witte","first_name":"Vanessa"},{"full_name":"Laffert, Bernd","first_name":"Bernd","last_name":"Laffert"},{"full_name":"Rosorius, Olaf","first_name":"Olaf","last_name":"Rosorius"},{"full_name":"Lischka, Peter","last_name":"Lischka","first_name":"Peter"},{"full_name":"Blume, Katja","last_name":"Blume","first_name":"Katja"},{"last_name":"Galler","first_name":"Gunther","full_name":"Galler, Gunther"},{"last_name":"Stilper","first_name":"Andrea","full_name":"Stilper, Andrea"},{"last_name":"Willbold","first_name":"Dieter","full_name":"Willbold, Dieter"},{"first_name":"Paola","last_name":"D'Aloja","full_name":"D'Aloja, Paola"},{"last_name":"Sixt","first_name":"Michael K","orcid":"0000-0002-6620-9179","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","full_name":"Michael Sixt"},{"full_name":"Kolanus, Johanna","last_name":"Kolanus","first_name":"Johanna"},{"full_name":"Ott, Melanie","last_name":"Ott","first_name":"Melanie"},{"last_name":"Kolanus","first_name":"Waldemar","full_name":"Kolanus, Waldemar"},{"full_name":"Schuler, Gerold","last_name":"Schuler","first_name":"Gerold"},{"full_name":"Baur, Andreas S","last_name":"Baur","first_name":"Andreas"}],"citation":{"ieee":"V. Witte <i>et al.</i>, “HIV-1 Nef mimics an integrin receptor signal that recruits the polycomb group protein Eed to the plasma membrane,” <i>Molecular Cell</i>, vol. 13, no. 2. Cell Press, pp. 179–190, 2004.","apa":"Witte, V., Laffert, B., Rosorius, O., Lischka, P., Blume, K., Galler, G., … Baur, A. (2004). HIV-1 Nef mimics an integrin receptor signal that recruits the polycomb group protein Eed to the plasma membrane. <i>Molecular Cell</i>. Cell Press. <a href=\"https://doi.org/10.1016/S1097-2765(04)00004-8\">https://doi.org/10.1016/S1097-2765(04)00004-8</a>","ista":"Witte V, Laffert B, Rosorius O, Lischka P, Blume K, Galler G, Stilper A, Willbold D, D’Aloja P, Sixt MK, Kolanus J, Ott M, Kolanus W, Schuler G, Baur A. 2004. HIV-1 Nef mimics an integrin receptor signal that recruits the polycomb group protein Eed to the plasma membrane. Molecular Cell. 13(2), 179–190.","ama":"Witte V, Laffert B, Rosorius O, et al. HIV-1 Nef mimics an integrin receptor signal that recruits the polycomb group protein Eed to the plasma membrane. <i>Molecular Cell</i>. 2004;13(2):179-190. doi:<a href=\"https://doi.org/10.1016/S1097-2765(04)00004-8\">10.1016/S1097-2765(04)00004-8</a>","chicago":"Witte, Vanessa, Bernd Laffert, Olaf Rosorius, Peter Lischka, Katja Blume, Gunther Galler, Andrea Stilper, et al. “HIV-1 Nef Mimics an Integrin Receptor Signal That Recruits the Polycomb Group Protein Eed to the Plasma Membrane.” <i>Molecular Cell</i>. Cell Press, 2004. <a href=\"https://doi.org/10.1016/S1097-2765(04)00004-8\">https://doi.org/10.1016/S1097-2765(04)00004-8</a>.","mla":"Witte, Vanessa, et al. “HIV-1 Nef Mimics an Integrin Receptor Signal That Recruits the Polycomb Group Protein Eed to the Plasma Membrane.” <i>Molecular Cell</i>, vol. 13, no. 2, Cell Press, 2004, pp. 179–90, doi:<a href=\"https://doi.org/10.1016/S1097-2765(04)00004-8\">10.1016/S1097-2765(04)00004-8</a>.","short":"V. Witte, B. Laffert, O. Rosorius, P. Lischka, K. Blume, G. Galler, A. Stilper, D. Willbold, P. D’Aloja, M.K. Sixt, J. Kolanus, M. Ott, W. Kolanus, G. Schuler, A. Baur, Molecular Cell 13 (2004) 179–190."},"date_updated":"2021-01-12T07:53:16Z","extern":1,"quality_controlled":0,"volume":13,"title":"HIV-1 Nef mimics an integrin receptor signal that recruits the polycomb group protein Eed to the plasma membrane","date_published":"2004-01-30T00:00:00Z","publisher":"Cell Press","issue":"2","abstract":[{"lang":"eng","text":"The Nef protein of human and simian immunodeficiency virus (HIV/SIV) is believed to interfere with T cell activation signals by forming a signaling complex at the plasma membrane. Composition and function of the complex are not fully understood. Here we report that Nef recruits the Polycomb Group (PcG) protein Eed, so far known as a nuclear factor and repressor of transcription, to the membrane of cells. The Nef-induced translocation of Eed led to a potent stimulation of Tat-dependent HIV transcription, implying that Eed removal from the nucleus is required for optimal Tat function. Similar to Nef action, activation of integrin receptors recruited Eed to the plasma membrane, also leading to enhanced Tat/Nef-mediated transcription. Our results suggest a link between membrane-associated activation processes and transcriptional derepression and demonstrate how HIV exploits this mechanism."}],"publication_status":"published","month":"01","status":"public","day":"30","page":"179 - 190","year":"2004","doi":"10.1016/S1097-2765(04)00004-8","type":"journal_article","_id":"3929","date_created":"2018-12-11T12:05:56Z","publication":"Molecular Cell","intvolume":"        13","publist_id":"2197"},{"author":[{"full_name":"Zhang, Hui","first_name":"Hui","last_name":"Zhang"},{"last_name":"Baader","first_name":"Stephan","full_name":"Baader, Stephan L"},{"orcid":"0000-0002-6620-9179","first_name":"Michael K","last_name":"Sixt","full_name":"Michael Sixt","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Kappler, Joachim","last_name":"Kappler","first_name":"Joachim"},{"first_name":"Uwe","last_name":"Rauch","full_name":"Rauch, Uwe"}],"citation":{"ieee":"H. Zhang, S. Baader, M. K. Sixt, J. Kappler, and U. Rauch, “Neurocan-GFP fusion protein: a new approach to detect hyaluronan on tissue sections and living cells,” <i>Journal of Histochemistry and Cytochemistry</i>, vol. 52, no. 7. Histochemical Society, pp. 915–922, 2004.","chicago":"Zhang, Hui, Stephan Baader, Michael K Sixt, Joachim Kappler, and Uwe Rauch. “Neurocan-GFP Fusion Protein: A New Approach to Detect Hyaluronan on Tissue Sections and Living Cells.” <i>Journal of Histochemistry and Cytochemistry</i>. Histochemical Society, 2004. <a href=\"https://doi.org/10.1369/jhc.3A6221.2004\">https://doi.org/10.1369/jhc.3A6221.2004</a>.","ista":"Zhang H, Baader S, Sixt MK, Kappler J, Rauch U. 2004. Neurocan-GFP fusion protein: a new approach to detect hyaluronan on tissue sections and living cells. Journal of Histochemistry and Cytochemistry. 52(7), 915–922.","ama":"Zhang H, Baader S, Sixt MK, Kappler J, Rauch U. Neurocan-GFP fusion protein: a new approach to detect hyaluronan on tissue sections and living cells. <i>Journal of Histochemistry and Cytochemistry</i>. 2004;52(7):915-922. doi:<a href=\"https://doi.org/10.1369/jhc.3A6221.2004\">10.1369/jhc.3A6221.2004</a>","apa":"Zhang, H., Baader, S., Sixt, M. K., Kappler, J., &#38; Rauch, U. (2004). Neurocan-GFP fusion protein: a new approach to detect hyaluronan on tissue sections and living cells. <i>Journal of Histochemistry and Cytochemistry</i>. Histochemical Society. <a href=\"https://doi.org/10.1369/jhc.3A6221.2004\">https://doi.org/10.1369/jhc.3A6221.2004</a>","mla":"Zhang, Hui, et al. “Neurocan-GFP Fusion Protein: A New Approach to Detect Hyaluronan on Tissue Sections and Living Cells.” <i>Journal of Histochemistry and Cytochemistry</i>, vol. 52, no. 7, Histochemical Society, 2004, pp. 915–22, doi:<a href=\"https://doi.org/10.1369/jhc.3A6221.2004\">10.1369/jhc.3A6221.2004</a>.","short":"H. Zhang, S. Baader, M.K. Sixt, J. Kappler, U. Rauch, Journal of Histochemistry and Cytochemistry 52 (2004) 915–922."},"date_updated":"2021-01-12T07:53:17Z","quality_controlled":0,"extern":1,"volume":52,"title":"Neurocan-GFP fusion protein: a new approach to detect hyaluronan on tissue sections and living cells","date_published":"2004-01-01T00:00:00Z","publisher":"Histochemical Society","issue":"7","abstract":[{"text":"Hyaluronan is an unsulfated glycosaminoglycan (GAG) that is ubiquitously expressed in the extracellular matrix (ECM) of all vertebrates, where hyaluronan rich matrices constitute a particular permissive environment for the development of complex biological structures and also for tumor progression. Because of its conserved structure and ubiquitous expression, antibodies for its histochemical detection cannot be produced. We have engineered a fusion protein, neurocan-GFP, and expressed it as a secreted molecule in mammalian cells. Neurocan-GFP fusion protein specifically binds to hyaluronan and directly visualizes hyaluronan on tissue sections, revealing a very detailed picture of hyaluronan distribution. The fluorescent fusion protein can be used in combination with antibodies and nuclear markers for double or triple staining. In addition, it is suitable to visualize hyaluronan on living cells by time-lapse video microscopy. The successful production and application of the neurocan-GFP fusion protein opens up new perspectives for using GFP fusion proteins as detection tools in histological and cytological studies complementing conventional antibody and biotin/avidin techniques.","lang":"eng"}],"publication_status":"published","month":"01","doi":"10.1369/jhc.3A6221.2004","page":"915 - 922","status":"public","year":"2004","day":"01","type":"journal_article","_id":"3931","date_created":"2018-12-11T12:05:57Z","publication":"Journal of Histochemistry and Cytochemistry","intvolume":"        52","publist_id":"2196"},{"intvolume":"        10","publist_id":"2139","publication":"IEEE Transactions on Visualization and Computer Graphics","date_created":"2018-12-11T12:06:16Z","_id":"3984","type":"journal_article","year":"2004","status":"public","day":"01","page":"385 - 396","doi":"10.1109/TVCG.2004.3","abstract":[{"text":"We combine topological and geometric methods to construct a multiresolution representation for a function over a two-dimensional domain. In a preprocessing stage, we create the Morse-Smale complex of the function and progressively simplify its topology by cancelling pairs of critical points. Based on a simple notion of dependency among these cancellations, we construct a hierarchical data structure supporting traversal and reconstruction operations similarly to traditional geometry-based representations. We use this data structure to extract topologically valid approximations that satisfy error bounds provided at runtime.","lang":"eng"}],"month":"07","publication_status":"published","issue":"4","date_published":"2004-07-01T00:00:00Z","publisher":"IEEE","title":"A topological hierarchy for functions on triangulated surfaces","volume":10,"date_updated":"2021-01-12T07:53:39Z","extern":1,"quality_controlled":0,"citation":{"mla":"Bremer, Peer, et al. “A Topological Hierarchy for Functions on Triangulated Surfaces.” <i>IEEE Transactions on Visualization and Computer Graphics</i>, vol. 10, no. 4, IEEE, 2004, pp. 385–96, doi:<a href=\"https://doi.org/10.1109/TVCG.2004.3\">10.1109/TVCG.2004.3</a>.","short":"P. Bremer, H. Edelsbrunner, B. Hamann, V. Pascucci, IEEE Transactions on Visualization and Computer Graphics 10 (2004) 385–396.","ista":"Bremer P, Edelsbrunner H, Hamann B, Pascucci V. 2004. A topological hierarchy for functions on triangulated surfaces. IEEE Transactions on Visualization and Computer Graphics. 10(4), 385–396.","chicago":"Bremer, Peer, Herbert Edelsbrunner, Bernd Hamann, and Valerio Pascucci. “A Topological Hierarchy for Functions on Triangulated Surfaces.” <i>IEEE Transactions on Visualization and Computer Graphics</i>. IEEE, 2004. <a href=\"https://doi.org/10.1109/TVCG.2004.3\">https://doi.org/10.1109/TVCG.2004.3</a>.","ama":"Bremer P, Edelsbrunner H, Hamann B, Pascucci V. A topological hierarchy for functions on triangulated surfaces. <i>IEEE Transactions on Visualization and Computer Graphics</i>. 2004;10(4):385-396. doi:<a href=\"https://doi.org/10.1109/TVCG.2004.3\">10.1109/TVCG.2004.3</a>","apa":"Bremer, P., Edelsbrunner, H., Hamann, B., &#38; Pascucci, V. (2004). A topological hierarchy for functions on triangulated surfaces. <i>IEEE Transactions on Visualization and Computer Graphics</i>. IEEE. <a href=\"https://doi.org/10.1109/TVCG.2004.3\">https://doi.org/10.1109/TVCG.2004.3</a>","ieee":"P. Bremer, H. Edelsbrunner, B. Hamann, and V. Pascucci, “A topological hierarchy for functions on triangulated surfaces,” <i>IEEE Transactions on Visualization and Computer Graphics</i>, vol. 10, no. 4. IEEE, pp. 385–396, 2004."},"author":[{"last_name":"Bremer","first_name":"Peer","full_name":"Bremer, Peer-Timo"},{"full_name":"Herbert Edelsbrunner","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-9823-6833","last_name":"Edelsbrunner","first_name":"Herbert"},{"first_name":"Bernd","last_name":"Hamann","full_name":"Hamann, Bernd"},{"full_name":"Pascucci, Valerio","first_name":"Valerio","last_name":"Pascucci"}]},{"publication":"Discrete & Computational Geometry","publist_id":"2140","intvolume":"        32","_id":"3985","type":"journal_article","date_created":"2018-12-11T12:06:16Z","year":"2004","status":"public","day":"01","doi":"10.1007/s00454-004-1122-6","page":"231 - 244","acknowledgement":"Partially supported by NSF under Grants EIA-99-72879 and CCR-00-86013.","issue":"2","publication_status":"published","month":"07","abstract":[{"text":"Given a Morse function f over a 2-manifold with or without boundary, the Reeb graph is obtained by contracting the connected components of the level sets to points. We prove tight upper and lower bounds on the number of loops in the Reeb graph that depend on the genus, the number of boundary components, and whether or not the 2-manifold is orientable. We also give an algorithm that constructs the Reeb graph in time O(n log n), where n is the number of edges in the triangulation used to represent the 2-manifold and the Morse function.","lang":"eng"}],"title":"Loops in Reeb graphs of 2-manifolds","volume":32,"publisher":"Springer","date_published":"2004-07-01T00:00:00Z","citation":{"short":"K. Cole Mclaughlin, H. Edelsbrunner, J. Harer, V. Natarajan, V. Pascucci, Discrete &#38; Computational Geometry 32 (2004) 231–244.","mla":"Cole Mclaughlin, Kree, et al. “Loops in Reeb Graphs of 2-Manifolds.” <i>Discrete &#38; Computational Geometry</i>, vol. 32, no. 2, Springer, 2004, pp. 231–44, doi:<a href=\"https://doi.org/10.1007/s00454-004-1122-6\">10.1007/s00454-004-1122-6</a>.","apa":"Cole Mclaughlin, K., Edelsbrunner, H., Harer, J., Natarajan, V., &#38; Pascucci, V. (2004). Loops in Reeb graphs of 2-manifolds. <i>Discrete &#38; Computational Geometry</i>. Springer. <a href=\"https://doi.org/10.1007/s00454-004-1122-6\">https://doi.org/10.1007/s00454-004-1122-6</a>","ama":"Cole Mclaughlin K, Edelsbrunner H, Harer J, Natarajan V, Pascucci V. Loops in Reeb graphs of 2-manifolds. <i>Discrete &#38; Computational Geometry</i>. 2004;32(2):231-244. doi:<a href=\"https://doi.org/10.1007/s00454-004-1122-6\">10.1007/s00454-004-1122-6</a>","ista":"Cole Mclaughlin K, Edelsbrunner H, Harer J, Natarajan V, Pascucci V. 2004. Loops in Reeb graphs of 2-manifolds. Discrete &#38; Computational Geometry. 32(2), 231–244.","chicago":"Cole Mclaughlin, Kree, Herbert Edelsbrunner, John Harer, Vijay Natarajan, and Valerio Pascucci. “Loops in Reeb Graphs of 2-Manifolds.” <i>Discrete &#38; Computational Geometry</i>. Springer, 2004. <a href=\"https://doi.org/10.1007/s00454-004-1122-6\">https://doi.org/10.1007/s00454-004-1122-6</a>.","ieee":"K. Cole Mclaughlin, H. Edelsbrunner, J. Harer, V. Natarajan, and V. Pascucci, “Loops in Reeb graphs of 2-manifolds,” <i>Discrete &#38; Computational Geometry</i>, vol. 32, no. 2. Springer, pp. 231–244, 2004."},"quality_controlled":0,"extern":1,"date_updated":"2021-01-12T07:53:39Z","author":[{"full_name":"Cole-McLaughlin, Kree","first_name":"Kree","last_name":"Cole Mclaughlin"},{"full_name":"Herbert Edelsbrunner","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-9823-6833","last_name":"Edelsbrunner","first_name":"Herbert"},{"full_name":"Harer, John","first_name":"John","last_name":"Harer"},{"last_name":"Natarajan","first_name":"Vijay","full_name":"Natarajan, Vijay"},{"full_name":"Pascucci, Valerio","last_name":"Pascucci","first_name":"Valerio"}]},{"issue":"3","month":"09","publication_status":"published","abstract":[{"text":"The motion of a biomolecule greatly depends on the engulfing solution, which is mostly water. Instead of representing individual water molecules, it is desirable to develop implicit solvent models that nevertheless accurately represent the contribution of the solvent interaction to the motion. In such models, hydrophobicity is expressed as a weighted sum of atomic surface areas. The derivatives of these weighted areas contribute to the force that drives the motion. In this paper we give formulas for the weighted and unweighted area derivatives of a molecule modeled as a space-filling diagram made up of balls in motion. Other than the radii and the centers of the balls, the formulas are given in terms of the sizes of circular arcs of the boundary and edges of the power diagram. We also give inclusion-exclusion formulas for these sizes.","lang":"eng"}],"volume":32,"title":"The area derivative of a space-filling diagram","publisher":"Springer","date_published":"2004-09-01T00:00:00Z","citation":{"short":"R. Bryant, H. Edelsbrunner, P. Koehl, M. Levitt, Discrete &#38; Computational Geometry 32 (2004) 293–308.","mla":"Bryant, Robert, et al. “The Area Derivative of a Space-Filling Diagram.” <i>Discrete &#38; Computational Geometry</i>, vol. 32, no. 3, Springer, 2004, pp. 293–308, doi:<a href=\"https://doi.org/10.1007/s00454-004-1099-1\">10.1007/s00454-004-1099-1</a>.","ieee":"R. Bryant, H. Edelsbrunner, P. Koehl, and M. Levitt, “The area derivative of a space-filling diagram,” <i>Discrete &#38; Computational Geometry</i>, vol. 32, no. 3. Springer, pp. 293–308, 2004.","ama":"Bryant R, Edelsbrunner H, Koehl P, Levitt M. The area derivative of a space-filling diagram. <i>Discrete &#38; Computational Geometry</i>. 2004;32(3):293-308. doi:<a href=\"https://doi.org/10.1007/s00454-004-1099-1\">10.1007/s00454-004-1099-1</a>","ista":"Bryant R, Edelsbrunner H, Koehl P, Levitt M. 2004. The area derivative of a space-filling diagram. Discrete &#38; Computational Geometry. 32(3), 293–308.","chicago":"Bryant, Robert, Herbert Edelsbrunner, Patrice Koehl, and Michael Levitt. “The Area Derivative of a Space-Filling Diagram.” <i>Discrete &#38; Computational Geometry</i>. Springer, 2004. <a href=\"https://doi.org/10.1007/s00454-004-1099-1\">https://doi.org/10.1007/s00454-004-1099-1</a>.","apa":"Bryant, R., Edelsbrunner, H., Koehl, P., &#38; Levitt, M. (2004). The area derivative of a space-filling diagram. <i>Discrete &#38; Computational Geometry</i>. Springer. <a href=\"https://doi.org/10.1007/s00454-004-1099-1\">https://doi.org/10.1007/s00454-004-1099-1</a>"},"extern":1,"quality_controlled":0,"date_updated":"2021-01-12T07:53:40Z","author":[{"first_name":"Robert","last_name":"Bryant","full_name":"Bryant, Robert"},{"first_name":"Herbert","last_name":"Edelsbrunner","orcid":"0000-0002-9823-6833","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","full_name":"Herbert Edelsbrunner"},{"first_name":"Patrice","last_name":"Koehl","full_name":"Koehl, Patrice"},{"full_name":"Levitt, Michael","last_name":"Levitt","first_name":"Michael"}],"publication":"Discrete & Computational Geometry","publist_id":"2141","intvolume":"        32","type":"journal_article","_id":"3986","date_created":"2018-12-11T12:06:17Z","year":"2004","doi":"10.1007/s00454-004-1099-1","day":"01","status":"public","page":"293 - 308","acknowledgement":"Partially supported by NSF under grant CCR-00-86013 and NSF under grant CCR-97-12088."},{"date_published":"2004-07-12T00:00:00Z","publisher":"IEEE","volume":10,"title":"Simplification of three-dimensional density maps","abstract":[{"text":"We consider scientific data sets that describe density functions over three-dimensional geometric domains. Such data sets are often large and coarsened representations are needed for visualization and analysis. Assuming a tetrahedral mesh representation, we construct such representations with a simplification algorithm that combines three goals: the approximation of the function, the preservation of the mesh topology, and the improvement of the mesh quality. The third goal is achieved with a novel extension of the well-known quadric error metric. We perform a number of computational experiments to understand the effect of mesh quality improvement on the density map approximation. In addition, we study the effect of geometric simplification on the topological features of the function by monitoring its critical points.","lang":"eng"}],"month":"07","publication_status":"published","issue":"5","author":[{"full_name":"Natarajan, Vijay","first_name":"Vijay","last_name":"Natarajan"},{"last_name":"Edelsbrunner","first_name":"Herbert","orcid":"0000-0002-9823-6833","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","full_name":"Herbert Edelsbrunner"}],"date_updated":"2021-01-12T07:53:40Z","quality_controlled":0,"extern":1,"citation":{"mla":"Natarajan, Vijay, and Herbert Edelsbrunner. “Simplification of Three-Dimensional Density Maps.” <i>IEEE Transactions on Visualization and Computer Graphics</i>, vol. 10, no. 5, IEEE, 2004, pp. 587–97, doi:<a href=\"https://doi.org/10.1109/TVCG.2004.32\">10.1109/TVCG.2004.32</a>.","short":"V. Natarajan, H. Edelsbrunner, IEEE Transactions on Visualization and Computer Graphics 10 (2004) 587–597.","chicago":"Natarajan, Vijay, and Herbert Edelsbrunner. “Simplification of Three-Dimensional Density Maps.” <i>IEEE Transactions on Visualization and Computer Graphics</i>. IEEE, 2004. <a href=\"https://doi.org/10.1109/TVCG.2004.32\">https://doi.org/10.1109/TVCG.2004.32</a>.","ama":"Natarajan V, Edelsbrunner H. Simplification of three-dimensional density maps. <i>IEEE Transactions on Visualization and Computer Graphics</i>. 2004;10(5):587-597. doi:<a href=\"https://doi.org/10.1109/TVCG.2004.32\">10.1109/TVCG.2004.32</a>","ista":"Natarajan V, Edelsbrunner H. 2004. Simplification of three-dimensional density maps. IEEE Transactions on Visualization and Computer Graphics. 10(5), 587–597.","apa":"Natarajan, V., &#38; Edelsbrunner, H. (2004). Simplification of three-dimensional density maps. <i>IEEE Transactions on Visualization and Computer Graphics</i>. IEEE. <a href=\"https://doi.org/10.1109/TVCG.2004.32\">https://doi.org/10.1109/TVCG.2004.32</a>","ieee":"V. Natarajan and H. Edelsbrunner, “Simplification of three-dimensional density maps,” <i>IEEE Transactions on Visualization and Computer Graphics</i>, vol. 10, no. 5. IEEE, pp. 587–597, 2004."},"intvolume":"        10","publist_id":"2142","publication":"IEEE Transactions on Visualization and Computer Graphics","doi":"10.1109/TVCG.2004.32","page":"587 - 597","status":"public","day":"12","year":"2004","date_created":"2018-12-11T12:06:17Z","_id":"3987","type":"journal_article"},{"status":"public","doi":"10.1007/978-3-540-30219-3_19","page":"218 - 229","year":"2004","day":"01","acknowledgement":"Supported by NSF under grant CCR-00-86013, BGT Postdoc Program from Duke University and NIH under grant R01 GM61822-01.","_id":"3988","type":"conference","date_created":"2018-12-11T12:06:17Z","conference":{"name":"WABI: 4th International Workshop on Algorithms in Bioinformatics"},"publist_id":"2136","intvolume":"      3240","alternative_title":["LNCS"],"author":[{"full_name":"Choi, Vicky","last_name":"Choi","first_name":"Vicky"},{"last_name":"Agarwal","first_name":"Pankaj","full_name":"Agarwal, Pankaj K"},{"orcid":"0000-0002-9823-6833","last_name":"Edelsbrunner","first_name":"Herbert","full_name":"Herbert Edelsbrunner","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Rudolph","first_name":"Johannes","full_name":"Rudolph, Johannes"}],"citation":{"ista":"Choi V, Agarwal P, Edelsbrunner H, Rudolph J. 2004. Local search heuristic for rigid protein docking. WABI: 4th International Workshop on Algorithms in Bioinformatics, LNCS, vol. 3240, 218–229.","chicago":"Choi, Vicky, Pankaj Agarwal, Herbert Edelsbrunner, and Johannes Rudolph. “Local Search Heuristic for Rigid Protein Docking,” 3240:218–29. Springer, 2004. <a href=\"https://doi.org/10.1007/978-3-540-30219-3_19\">https://doi.org/10.1007/978-3-540-30219-3_19</a>.","ama":"Choi V, Agarwal P, Edelsbrunner H, Rudolph J. Local search heuristic for rigid protein docking. In: Vol 3240. Springer; 2004:218-229. doi:<a href=\"https://doi.org/10.1007/978-3-540-30219-3_19\">10.1007/978-3-540-30219-3_19</a>","apa":"Choi, V., Agarwal, P., Edelsbrunner, H., &#38; Rudolph, J. (2004). Local search heuristic for rigid protein docking (Vol. 3240, pp. 218–229). Presented at the WABI: 4th International Workshop on Algorithms in Bioinformatics, Springer. <a href=\"https://doi.org/10.1007/978-3-540-30219-3_19\">https://doi.org/10.1007/978-3-540-30219-3_19</a>","ieee":"V. Choi, P. Agarwal, H. Edelsbrunner, and J. Rudolph, “Local search heuristic for rigid protein docking,” presented at the WABI: 4th International Workshop on Algorithms in Bioinformatics, 2004, vol. 3240, pp. 218–229.","short":"V. Choi, P. Agarwal, H. Edelsbrunner, J. Rudolph, in:, Springer, 2004, pp. 218–229.","mla":"Choi, Vicky, et al. <i>Local Search Heuristic for Rigid Protein Docking</i>. Vol. 3240, Springer, 2004, pp. 218–29, doi:<a href=\"https://doi.org/10.1007/978-3-540-30219-3_19\">10.1007/978-3-540-30219-3_19</a>."},"quality_controlled":0,"extern":1,"date_updated":"2021-01-12T07:53:41Z","volume":3240,"title":"Local search heuristic for rigid protein docking","date_published":"2004-01-01T00:00:00Z","publisher":"Springer","month":"01","publication_status":"published","abstract":[{"text":"We give an algorithm that locally improves the fit between two proteins modeled as space-filling diagrams. The algorithm defines the fit in purely geometric terms and improves by applying a rigid motion to one of the two proteins. Our implementation of the algorithm takes between three and ten seconds and converges with high likelihood to the correct docked configuration, provided it starts at a position away from the correct one by at most 18 degrees of rotation and at most 3.0Angstrom of translation. The speed and convergence radius make this an attractive algorithm to use in combination with a coarse sampling of the six-dimensional space of rigid motions.","lang":"eng"}]},{"doi":"10.1109/VISUAL.2004.68","status":"public","day":"01","year":"2004","page":"275 - 280","date_created":"2018-12-11T12:06:18Z","_id":"3989","type":"conference","publist_id":"2137","conference":{"name":"VIS: IEEE Visualization"},"author":[{"orcid":"0000-0002-9823-6833","last_name":"Edelsbrunner","first_name":"Herbert","full_name":"Herbert Edelsbrunner","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Harer, John","first_name":"John","last_name":"Harer"},{"full_name":"Natarajan, Vijay","first_name":"Vijay","last_name":"Natarajan"},{"full_name":"Pascucci, Valerio","last_name":"Pascucci","first_name":"Valerio"}],"date_updated":"2021-01-12T07:53:41Z","extern":1,"quality_controlled":0,"citation":{"short":"H. Edelsbrunner, J. Harer, V. Natarajan, V. Pascucci, in:, IEEE, 2004, pp. 275–280.","mla":"Edelsbrunner, Herbert, et al. <i>Local and Global Comparison of Continuous Functions</i>. IEEE, 2004, pp. 275–80, doi:<a href=\"https://doi.org/10.1109/VISUAL.2004.68\">10.1109/VISUAL.2004.68</a>.","ieee":"H. Edelsbrunner, J. Harer, V. Natarajan, and V. Pascucci, “Local and global comparison of continuous functions,” presented at the VIS: IEEE Visualization, 2004, pp. 275–280.","apa":"Edelsbrunner, H., Harer, J., Natarajan, V., &#38; Pascucci, V. (2004). Local and global comparison of continuous functions (pp. 275–280). Presented at the VIS: IEEE Visualization, IEEE. <a href=\"https://doi.org/10.1109/VISUAL.2004.68\">https://doi.org/10.1109/VISUAL.2004.68</a>","ista":"Edelsbrunner H, Harer J, Natarajan V, Pascucci V. 2004. Local and global comparison of continuous functions. VIS: IEEE Visualization, 275–280.","ama":"Edelsbrunner H, Harer J, Natarajan V, Pascucci V. Local and global comparison of continuous functions. In: IEEE; 2004:275-280. doi:<a href=\"https://doi.org/10.1109/VISUAL.2004.68\">10.1109/VISUAL.2004.68</a>","chicago":"Edelsbrunner, Herbert, John Harer, Vijay Natarajan, and Valerio Pascucci. “Local and Global Comparison of Continuous Functions,” 275–80. IEEE, 2004. <a href=\"https://doi.org/10.1109/VISUAL.2004.68\">https://doi.org/10.1109/VISUAL.2004.68</a>."},"date_published":"2004-10-01T00:00:00Z","publisher":"IEEE","title":"Local and global comparison of continuous functions","abstract":[{"lang":"eng","text":"We introduce local and global comparison measures for a collection of k less than or equal to d real-valued smooth functions on a common d-dimensional Riemannian manifold. For k = d = 2 we relate the measures to the set of critical points of one function restricted to the level sets of the other. The definition of the measures extends to piecewise linear functions for which they ace easy to compute. The computation of the measures forms the centerpiece of a software tool which we use to study scientific datasets."}],"publication_status":"published","month":"10"},{"publist_id":"2138","intvolume":"        32","publication":"Discrete & Computational Geometry","date_created":"2018-12-11T12:06:18Z","_id":"3990","type":"journal_article","acknowledgement":"Partially supported by NSF under grants CCR-00-86013, EIA-9972879 and NSF under grant CCR-97-12088.","page":"37 - 53","status":"public","day":"01","year":"2004","doi":"10.1007/s00454-004-2864-x","publication_status":"published","month":"05","abstract":[{"text":"The writhing number measures the global geometry of a closed space curve or knot. We show that this measure is related to the average winding number of its Gauss map. Using this relationship, we give an algorithm for computing the writhing number for a polygonal knot with n edges in time roughly proportional to n(1.6). We also implement a different, simple algorithm and provide experimental evidence for its practical efficiency.","lang":"eng"}],"issue":"1","date_published":"2004-05-01T00:00:00Z","publisher":"Springer","title":"Computing the writhing number of a polygonal knot","volume":32,"extern":1,"quality_controlled":0,"date_updated":"2021-01-12T07:53:42Z","citation":{"ista":"Agarwal P, Edelsbrunner H, Wang Y. 2004. Computing the writhing number of a polygonal knot. Discrete &#38; Computational Geometry. 32(1), 37–53.","ama":"Agarwal P, Edelsbrunner H, Wang Y. Computing the writhing number of a polygonal knot. <i>Discrete &#38; Computational Geometry</i>. 2004;32(1):37-53. doi:<a href=\"https://doi.org/10.1007/s00454-004-2864-x\">10.1007/s00454-004-2864-x</a>","chicago":"Agarwal, Pankaj, Herbert Edelsbrunner, and Yusu Wang. “Computing the Writhing Number of a Polygonal Knot.” <i>Discrete &#38; Computational Geometry</i>. Springer, 2004. <a href=\"https://doi.org/10.1007/s00454-004-2864-x\">https://doi.org/10.1007/s00454-004-2864-x</a>.","apa":"Agarwal, P., Edelsbrunner, H., &#38; Wang, Y. (2004). Computing the writhing number of a polygonal knot. <i>Discrete &#38; Computational Geometry</i>. Springer. <a href=\"https://doi.org/10.1007/s00454-004-2864-x\">https://doi.org/10.1007/s00454-004-2864-x</a>","ieee":"P. Agarwal, H. Edelsbrunner, and Y. Wang, “Computing the writhing number of a polygonal knot,” <i>Discrete &#38; Computational Geometry</i>, vol. 32, no. 1. Springer, pp. 37–53, 2004.","short":"P. Agarwal, H. Edelsbrunner, Y. Wang, Discrete &#38; Computational Geometry 32 (2004) 37–53.","mla":"Agarwal, Pankaj, et al. “Computing the Writhing Number of a Polygonal Knot.” <i>Discrete &#38; Computational Geometry</i>, vol. 32, no. 1, Springer, 2004, pp. 37–53, doi:<a href=\"https://doi.org/10.1007/s00454-004-2864-x\">10.1007/s00454-004-2864-x</a>."},"author":[{"full_name":"Agarwal, Pankaj K","last_name":"Agarwal","first_name":"Pankaj"},{"id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","full_name":"Herbert Edelsbrunner","first_name":"Herbert","last_name":"Edelsbrunner","orcid":"0000-0002-9823-6833"},{"first_name":"Yusu","last_name":"Wang","full_name":"Wang, Yusu"}]},{"abstract":[{"text":"During vertebrate gastrulation, a relatively limited number of blastodermal cells undergoes a stereotypical set of cellular movements that leads to formation of the three germ layers: ectoderm, mesoderm and endoderm. Gastrulation, therefore, provides a unique developmental system in which to study cell movements in vivo in a fairly simple cellular context. Recent advances have been made in elucidating the cellular and molecular mechanisms that underlie cell movements during zebrafish gastrulation. These findings can be compared with observations made in other model systems to identify potential general mechanisms of cell migration during development.","lang":"eng"}],"month":"11","publication_status":"published","issue":"11","date_published":"2004-11-01T00:00:00Z","language":[{"iso":"eng"}],"publisher":"Cell Press","article_processing_charge":"No","title":"Gastrulation dynamics: cells move into focus","volume":14,"date_updated":"2021-01-12T07:55:02Z","extern":"1","oa_version":"None","citation":{"mla":"Montero, Juan, and Carl-Philipp J. Heisenberg. “Gastrulation Dynamics: Cells Move into Focus.” <i>Trends in Cell Biology</i>, vol. 14, no. 11, Cell Press, 2004, pp. 620–27, doi:<a href=\"https://doi.org/10.1016/j.tcb.2004.09.008\">10.1016/j.tcb.2004.09.008</a>.","short":"J. Montero, C.-P.J. Heisenberg, Trends in Cell Biology 14 (2004) 620–627.","ama":"Montero J, Heisenberg C-PJ. Gastrulation dynamics: cells move into focus. <i>Trends in Cell Biology</i>. 2004;14(11):620-627. doi:<a href=\"https://doi.org/10.1016/j.tcb.2004.09.008\">10.1016/j.tcb.2004.09.008</a>","ista":"Montero J, Heisenberg C-PJ. 2004. Gastrulation dynamics: cells move into focus. Trends in Cell Biology. 14(11), 620–627.","chicago":"Montero, Juan, and Carl-Philipp J Heisenberg. “Gastrulation Dynamics: Cells Move into Focus.” <i>Trends in Cell Biology</i>. Cell Press, 2004. <a href=\"https://doi.org/10.1016/j.tcb.2004.09.008\">https://doi.org/10.1016/j.tcb.2004.09.008</a>.","apa":"Montero, J., &#38; Heisenberg, C.-P. J. (2004). Gastrulation dynamics: cells move into focus. <i>Trends in Cell Biology</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.tcb.2004.09.008\">https://doi.org/10.1016/j.tcb.2004.09.008</a>","ieee":"J. Montero and C.-P. J. Heisenberg, “Gastrulation dynamics: cells move into focus,” <i>Trends in Cell Biology</i>, vol. 14, no. 11. Cell Press, pp. 620–627, 2004."},"author":[{"last_name":"Montero","first_name":"Juan","full_name":"Montero, Juan"},{"id":"39427864-F248-11E8-B48F-1D18A9856A87","full_name":"Heisenberg, Carl-Philipp J","first_name":"Carl-Philipp J","last_name":"Heisenberg","orcid":"0000-0002-0912-4566"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":"        14","publist_id":"1948","publication":"Trends in Cell Biology","date_created":"2018-12-11T12:07:23Z","_id":"4172","type":"journal_article","page":"620 - 627","status":"public","doi":"10.1016/j.tcb.2004.09.008","year":"2004","day":"01"},{"oa_version":"None","citation":{"ieee":"K. Kruse, P. Pantazis, M. T. Bollenbach, F. Julicher, and M. Gonzalez Gaitan, “Dpp gradient formation by dynamin-dependent endocytosis: receptor trafficking and the diffusion model,” <i>Development</i>, vol. 131, no. 19. Company of Biologists, pp. 4843–4856, 2004.","ama":"Kruse K, Pantazis P, Bollenbach MT, Julicher F, Gonzalez Gaitan M. Dpp gradient formation by dynamin-dependent endocytosis: receptor trafficking and the diffusion model. <i>Development</i>. 2004;131(19):4843-4856. doi:<a href=\"https://doi.org/10.1242/dev.01335\">10.1242/dev.01335</a>","ista":"Kruse K, Pantazis P, Bollenbach MT, Julicher F, Gonzalez Gaitan M. 2004. Dpp gradient formation by dynamin-dependent endocytosis: receptor trafficking and the diffusion model. Development. 131(19), 4843–4856.","chicago":"Kruse, Karsten, Periklis Pantazis, Mark Tobias Bollenbach, Frank Julicher, and Marcos Gonzalez Gaitan. “Dpp Gradient Formation by Dynamin-Dependent Endocytosis: Receptor Trafficking and the Diffusion Model.” <i>Development</i>. Company of Biologists, 2004. <a href=\"https://doi.org/10.1242/dev.01335\">https://doi.org/10.1242/dev.01335</a>.","apa":"Kruse, K., Pantazis, P., Bollenbach, M. T., Julicher, F., &#38; Gonzalez Gaitan, M. (2004). Dpp gradient formation by dynamin-dependent endocytosis: receptor trafficking and the diffusion model. <i>Development</i>. Company of Biologists. <a href=\"https://doi.org/10.1242/dev.01335\">https://doi.org/10.1242/dev.01335</a>","short":"K. Kruse, P. Pantazis, M.T. Bollenbach, F. Julicher, M. Gonzalez Gaitan, Development 131 (2004) 4843–4856.","mla":"Kruse, Karsten, et al. “Dpp Gradient Formation by Dynamin-Dependent Endocytosis: Receptor Trafficking and the Diffusion Model.” <i>Development</i>, vol. 131, no. 19, Company of Biologists, 2004, pp. 4843–56, doi:<a href=\"https://doi.org/10.1242/dev.01335\">10.1242/dev.01335</a>."},"extern":"1","date_updated":"2021-01-12T07:55:26Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"first_name":"Karsten","last_name":"Kruse","full_name":"Kruse, Karsten"},{"last_name":"Pantazis","first_name":"Periklis","full_name":"Pantazis, Periklis"},{"orcid":"0000-0003-4398-476X","first_name":"Mark Tobias","last_name":"Bollenbach","full_name":"Bollenbach, Mark Tobias","id":"3E6DB97A-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Frank","last_name":"Julicher","full_name":"Julicher, Frank"},{"full_name":"Gonzalez Gaitan, Marcos","last_name":"Gonzalez Gaitan","first_name":"Marcos"}],"issue":"19","publication_status":"published","month":"01","abstract":[{"lang":"eng","text":"Developing cells acquire positional information by reading the graded distribution of morphogens. In Drosophila, the Dpp morphogen forms a long-range concentration gradient by spreading from a restricted source in the developing wing. It has been assumed that Dpp spreads by extracellular diffusion. Under this assumption, the main role of endocytosis in gradient formation is to downregulate receptors at the cell surface. These surface receptors bind to the ligand and thereby interfere with its long-range movement. Recent experiments indicate that Dpp spreading is mediated by Dynamin-dependent endocytosis in the target tissue, suggesting that extracellular diffusion alone cannot account for Dpp dispersal. Here, we perform a theoretical study of a model for morphogen spreading based on extracellular diffusion, which takes into account receptor binding and trafficking. We compare profiles of ligand and surface receptors obtained in this model with experimental data. To this end, we monitored directly the pool of surface receptors and extracellular Dpp with specific antibodies. We conclude that current models considering pure extracellular diffusion cannot explain the observed role of endocytosis during Dpp long-range movement."}],"volume":131,"title":"Dpp gradient formation by dynamin-dependent endocytosis: receptor trafficking and the diffusion model","article_processing_charge":"No","date_published":"2004-01-01T00:00:00Z","language":[{"iso":"eng"}],"publisher":"Company of Biologists","type":"journal_article","_id":"4224","date_created":"2018-12-11T12:07:41Z","status":"public","doi":"10.1242/dev.01335","page":"4843 - 4856","year":"2004","day":"01","publication":"Development","publist_id":"1893","intvolume":"       131"},{"publist_id":"1884","publication":"Life in the Universe From the Miller Experiment to the Search for Life on Other Worlds","editor":[{"full_name":"Hanslmeier,A.","first_name":"A.","last_name":"Hanslmeier"},{"full_name":"Kempe,S.","first_name":"S.","last_name":"Kempe"},{"full_name":"Seckbach,J.","last_name":"Seckbach","first_name":"J."}],"day":"31","page":"83 - 87","status":"public","year":"2004","date_created":"2018-12-11T12:07:44Z","type":"book_chapter","_id":"4230","publisher":"Springer","date_published":"2004-12-31T00:00:00Z","title":"A mechanism for the prebiotic emergence of proteins","month":"12","publication_status":"published","author":[{"orcid":"0000-0002-5985-7653","last_name":"Vladar","first_name":"Harold","full_name":"Harold Vladar","id":"2A181218-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Cipriani","first_name":"Roberto","full_name":"Cipriani, Roberto"},{"full_name":"Scharifker, Benjamin","last_name":"Scharifker","first_name":"Benjamin"},{"last_name":"Bubis","first_name":"Jose","full_name":"Bubis, Jose"}],"alternative_title":["Cellular Origin and Life in Extreme Habitats and Astrobiology"],"quality_controlled":0,"extern":1,"date_updated":"2021-01-12T07:55:28Z","citation":{"mla":"de Vladar, Harold, et al. “A Mechanism for the Prebiotic Emergence of Proteins.” <i>Life in the Universe From the Miller Experiment to the Search for Life on Other Worlds</i>, edited by A. Hanslmeier et al., Springer, 2004, pp. 83–87.","short":"H. de Vladar, R. Cipriani, B. Scharifker, J. Bubis, in:, A. Hanslmeier, S. Kempe, J. Seckbach (Eds.), Life in the Universe From the Miller Experiment to the Search for Life on Other Worlds, Springer, 2004, pp. 83–87.","ieee":"H. de Vladar, R. Cipriani, B. Scharifker, and J. Bubis, “A mechanism for the prebiotic emergence of proteins,” in <i>Life in the Universe From the Miller Experiment to the Search for Life on Other Worlds</i>, A. Hanslmeier, S. Kempe, and J. Seckbach, Eds. Springer, 2004, pp. 83–87.","apa":"de Vladar, H., Cipriani, R., Scharifker, B., &#38; Bubis, J. (2004). A mechanism for the prebiotic emergence of proteins. In A. Hanslmeier, S. Kempe, &#38; J. Seckbach (Eds.), <i>Life in the Universe From the Miller Experiment to the Search for Life on Other Worlds</i> (pp. 83–87). Springer.","ama":"de Vladar H, Cipriani R, Scharifker B, Bubis J. A mechanism for the prebiotic emergence of proteins. In: Hanslmeier A, Kempe S, Seckbach J, eds. <i>Life in the Universe From the Miller Experiment to the Search for Life on Other Worlds</i>. Springer; 2004:83-87.","chicago":"Vladar, Harold de, Roberto Cipriani, Benjamin Scharifker, and Jose Bubis. “A Mechanism for the Prebiotic Emergence of Proteins.” In <i>Life in the Universe From the Miller Experiment to the Search for Life on Other Worlds</i>, edited by A. Hanslmeier, S. Kempe, and J. Seckbach, 83–87. Springer, 2004.","ista":"de Vladar H, Cipriani R, Scharifker B, Bubis J. 2004.A mechanism for the prebiotic emergence of proteins. In: Life in the Universe From the Miller Experiment to the Search for Life on Other Worlds. Cellular Origin and Life in Extreme Habitats and Astrobiology, , 83–87."}},{"article_processing_charge":"No","title":"Métodos no lineales y sus aplicaciones en dinámicas aleatorias de poblaciones celulares","language":[{"iso":"eng"}],"date_published":"2004-01-01T00:00:00Z","publisher":"Centro de estudios avazados, IVIC","month":"01","publication_status":"published","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"first_name":"Harold","last_name":"de Vladar","orcid":"0000-0002-5985-7653","id":"2A181218-F248-11E8-B48F-1D18A9856A87","full_name":"de Vladar, Harold"}],"citation":{"apa":"de Vladar, H. (2004). <i>Métodos no lineales y sus aplicaciones en dinámicas aleatorias de poblaciones celulares</i>. Centro de estudios avazados, IVIC. <a href=\"https://doi.org/3810\">https://doi.org/3810</a>","ama":"de Vladar H. Métodos no lineales y sus aplicaciones en dinámicas aleatorias de poblaciones celulares. 2004. doi:<a href=\"https://doi.org/3810\">3810</a>","ista":"de Vladar H. 2004. Métodos no lineales y sus aplicaciones en dinámicas aleatorias de poblaciones celulares. Centro de estudios avazados, IVIC.","chicago":"Vladar, Harold de. “Métodos No Lineales y Sus Aplicaciones En Dinámicas Aleatorias de Poblaciones Celulares.” Centro de estudios avazados, IVIC, 2004. <a href=\"https://doi.org/3810\">https://doi.org/3810</a>.","ieee":"H. de Vladar, “Métodos no lineales y sus aplicaciones en dinámicas aleatorias de poblaciones celulares,” Centro de estudios avazados, IVIC, 2004.","mla":"de Vladar, Harold. <i>Métodos No Lineales y Sus Aplicaciones En Dinámicas Aleatorias de Poblaciones Celulares</i>. Centro de estudios avazados, IVIC, 2004, doi:<a href=\"https://doi.org/3810\">3810</a>.","short":"H. de Vladar, Métodos No Lineales y Sus Aplicaciones En Dinámicas Aleatorias de Poblaciones Celulares, Centro de estudios avazados, IVIC, 2004."},"oa_version":"None","date_updated":"2021-01-12T07:55:30Z","extern":"1","publist_id":"1877","year":"2004","status":"public","doi":"3810","day":"01","_id":"4236","type":"dissertation","date_created":"2018-12-11T12:07:46Z"},{"oa_version":"None","citation":{"apa":"de Vladar, H., &#38; González, J. (2004). Dynamic response of cancer under the influence of immunological activity and therapy. <i>Journal of Theoretical Biology</i>. Elsevier. <a href=\"https://doi.org/3801\">https://doi.org/3801</a>","ista":"de Vladar H, González J. 2004. Dynamic response of cancer under the influence of immunological activity and therapy. Journal of Theoretical Biology. 227(3), 335–348.","chicago":"Vladar, Harold de, and J. González. “Dynamic Response of Cancer under the Influence of Immunological Activity and Therapy.” <i>Journal of Theoretical Biology</i>. Elsevier, 2004. <a href=\"https://doi.org/3801\">https://doi.org/3801</a>.","ama":"de Vladar H, González J. Dynamic response of cancer under the influence of immunological activity and therapy. <i>Journal of Theoretical Biology</i>. 2004;227(3):335-348. doi:<a href=\"https://doi.org/3801\">3801</a>","ieee":"H. de Vladar and J. González, “Dynamic response of cancer under the influence of immunological activity and therapy,” <i>Journal of Theoretical Biology</i>, vol. 227, no. 3. Elsevier, pp. 335–348, 2004.","short":"H. de Vladar, J. González, Journal of Theoretical Biology 227 (2004) 335–348.","mla":"de Vladar, Harold, and J. González. “Dynamic Response of Cancer under the Influence of Immunological Activity and Therapy.” <i>Journal of Theoretical Biology</i>, vol. 227, no. 3, Elsevier, 2004, pp. 335–48, doi:<a href=\"https://doi.org/3801\">3801</a>."},"date_updated":"2021-01-12T07:55:31Z","extern":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"full_name":"de Vladar, Harold","id":"2A181218-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-5985-7653","last_name":"de Vladar","first_name":"Harold"},{"full_name":"González, J.","last_name":"González","first_name":"J."}],"issue":"3","abstract":[{"lang":"eng","text":"The dynamical basis of tumoral growth has been controversial. Many models have been proposed to explain cancer development. The descriptions employ exponential, potential, logistic or Gompertzian growth laws. Some of these models are concerned with the interaction between cancer and the immunological, system. Among other properties, these models are concerned with the microscopic behavior of tumors and the emergence of cancer. We propose a modification of a previous model by Stepanova, which describes the specific immunological response against cancer. The modification consists of the substitution of a Gompertian law for the exponential rate used for tumoral growth. This modification is motivated by the numerous works confirming that Gompertz's equation correctly describes solid tumor growth. The modified model predicts that near zero, tumors always tend to grow. Immunological contraposition never suffices to induce a complete regression of the tumor. Instead, a stable microscopic equilibrium between cancer and immunological activity can be attained. In other words, our model predicts that the theory of immune surveillance is plausible. A macroscopic equilibrium in which the system develops cancer is also possible. In this case, immunological activity is depleted. This is consistent with the phenomena of cancer tolerance. Both equilibrium points can coexist or can exist without the other. In all cases the fixed point at zero tumor size is unstable. Since immunity cannot induce a complete tumor regression, a therapy is required. We include constant-dose therapies and show that they are insufficient. Final levels of immunocompetent cells and tumoral cells are finite, thus post-treatment regrowth of the tumor is certain. We also evaluate late-intensification therapies which are successful. They induce an asymptotic regression to zero tumor size. Immune response is also suppressed by the therapy, and thus plays a negligible role in the remission. We conclude that treatment evaluation should be successful without taking into account immunological effects. (C) 2003 Elsevier Ltd. All rights reserved."}],"publication_status":"published","month":"01","article_processing_charge":"No","volume":227,"title":"Dynamic response of cancer under the influence of immunological activity and therapy","publisher":"Elsevier","language":[{"iso":"eng"}],"date_published":"2004-01-01T00:00:00Z","type":"journal_article","_id":"4238","date_created":"2018-12-11T12:07:46Z","doi":"3801","page":"335 - 348","status":"public","day":"01","year":"2004","publication":"Journal of Theoretical Biology","intvolume":"       227","publist_id":"1876"},{"editor":[{"last_name":"Seckbach","first_name":"J.","full_name":"Seckbach,J."},{"full_name":"Chela-Flores,J.","last_name":"Chela Flores","first_name":"J."},{"full_name":"Owen,T.","first_name":"T.","last_name":"Owen"},{"full_name":"Raulin,F.","last_name":"Raulin","first_name":"F."}],"publist_id":"1875","intvolume":"         7","publication":"Life in the Universe From the Miller Experiment to the Search for Life on Other Worlds","date_created":"2018-12-11T12:07:47Z","_id":"4239","type":"book_chapter","doi":"3807","page":"83 - 87","day":"01","status":"public","year":"2004","month":"01","publication_status":"published","date_published":"2004-01-01T00:00:00Z","publisher":"Springer","title":"A Mechanism for the Prebiotic Emergence of Proteins","volume":7,"extern":1,"quality_controlled":0,"date_updated":"2021-01-12T07:55:32Z","citation":{"chicago":"Vladar, Harold de, Roberto Cipriani, Benjamin Scharifker, and Jose Bubis. “A Mechanism for the Prebiotic Emergence of Proteins.” In <i>Life in the Universe From the Miller Experiment to the Search for Life on Other Worlds</i>, edited by J. Seckbach, J. Chela Flores, T. Owen, and F. Raulin, 7:83–87. Springer, 2004. <a href=\"https://doi.org/3807\">https://doi.org/3807</a>.","ista":"de Vladar H, Cipriani R, Scharifker B, Bubis J. 2004.A Mechanism for the Prebiotic Emergence of Proteins. In: Life in the Universe From the Miller Experiment to the Search for Life on Other Worlds. Cellular Origin, Life in Extreme Habitats and Astrobiology, vol. 7, 83–87.","ama":"de Vladar H, Cipriani R, Scharifker B, Bubis J. A Mechanism for the Prebiotic Emergence of Proteins. In: Seckbach J, Chela Flores J, Owen T, Raulin F, eds. <i>Life in the Universe From the Miller Experiment to the Search for Life on Other Worlds</i>. Vol 7. Springer; 2004:83-87. doi:<a href=\"https://doi.org/3807\">3807</a>","apa":"de Vladar, H., Cipriani, R., Scharifker, B., &#38; Bubis, J. (2004). A Mechanism for the Prebiotic Emergence of Proteins. In J. Seckbach, J. Chela Flores, T. Owen, &#38; F. Raulin (Eds.), <i>Life in the Universe From the Miller Experiment to the Search for Life on Other Worlds</i> (Vol. 7, pp. 83–87). Springer. <a href=\"https://doi.org/3807\">https://doi.org/3807</a>","ieee":"H. de Vladar, R. Cipriani, B. Scharifker, and J. Bubis, “A Mechanism for the Prebiotic Emergence of Proteins,” in <i>Life in the Universe From the Miller Experiment to the Search for Life on Other Worlds</i>, vol. 7, J. Seckbach, J. Chela Flores, T. Owen, and F. Raulin, Eds. Springer, 2004, pp. 83–87.","mla":"de Vladar, Harold, et al. “A Mechanism for the Prebiotic Emergence of Proteins.” <i>Life in the Universe From the Miller Experiment to the Search for Life on Other Worlds</i>, edited by J. Seckbach et al., vol. 7, Springer, 2004, pp. 83–87, doi:<a href=\"https://doi.org/3807\">3807</a>.","short":"H. de Vladar, R. Cipriani, B. Scharifker, J. Bubis, in:, J. Seckbach, J. Chela Flores, T. Owen, F. Raulin (Eds.), Life in the Universe From the Miller Experiment to the Search for Life on Other Worlds, Springer, 2004, pp. 83–87."},"author":[{"last_name":"Vladar","first_name":"Harold","orcid":"0000-0002-5985-7653","id":"2A181218-F248-11E8-B48F-1D18A9856A87","full_name":"Harold Vladar"},{"last_name":"Cipriani","first_name":"Roberto","full_name":"Cipriani, Roberto "},{"first_name":"Benjamin","last_name":"Scharifker","full_name":"Scharifker, Benjamin"},{"first_name":"Jose","last_name":"Bubis","full_name":"Bubis, Jose"}],"alternative_title":["Cellular Origin, Life in Extreme Habitats and Astrobiology"]}]