[{"acknowledged_ssus":[{"_id":"M-Shop"}],"publication_identifier":{"eissn":["20411723"]},"external_id":{"isi":["000767892300013"],"arxiv":["2107.08303"]},"scopus_import":"1","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","date_updated":"2024-10-29T09:11:06Z","has_accepted_license":"1","year":"2022","oa_version":"Published Version","article_type":"original","oa":1,"publication_status":"published","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"volume":13,"file_date_updated":"2022-03-28T08:02:12Z","article_processing_charge":"No","arxiv":1,"_id":"10924","abstract":[{"text":"Solid-state microwave systems offer strong interactions for fast quantum logic and sensing but photons at telecom wavelength are the ideal choice for high-density low-loss quantum interconnects. A general-purpose interface that can make use of single photon effects requires < 1 input noise quanta, which has remained elusive due to either low efficiency or pump induced heating. Here we demonstrate coherent electro-optic modulation on nanosecond-timescales with only 0.16+0.02−0.01 microwave input noise photons with a total bidirectional transduction efficiency of 8.7% (or up to 15% with 0.41+0.02−0.02), as required for near-term heralded quantum network protocols. The use of short and high-power optical pump pulses also enables near-unity cooperativity of the electro-optic interaction leading to an internal pure conversion efficiency of up to 99.5%. Together with the low mode occupancy this provides evidence for electro-optic laser cooling and vacuum amplification as predicted a decade ago.","lang":"eng"}],"date_published":"2022-03-11T00:00:00Z","article_number":"1276","file":[{"file_size":1167492,"creator":"dernst","file_name":"2022_NatureCommunications_Sahu.pdf","access_level":"open_access","date_updated":"2022-03-28T08:02:12Z","checksum":"7c5176db7b8e2ed18a4e0c5aca70a72c","relation":"main_file","file_id":"10929","content_type":"application/pdf","success":1,"date_created":"2022-03-28T08:02:12Z"}],"project":[{"call_identifier":"H2020","_id":"26336814-B435-11E9-9278-68D0E5697425","name":"A Fiber Optic Transceiver for Superconducting Qubits","grant_number":"758053"},{"grant_number":"899354","name":"Quantum Local Area Networks with Superconducting Qubits","_id":"9B868D20-BA93-11EA-9121-9846C619BF3A","call_identifier":"H2020"},{"call_identifier":"H2020","_id":"260C2330-B435-11E9-9278-68D0E5697425","name":"ISTplus - Postdoctoral Fellowships","grant_number":"754411"},{"name":"Integrating superconducting quantum circuits","grant_number":"F07105","_id":"26927A52-B435-11E9-9278-68D0E5697425","call_identifier":"FWF"},{"name":"Quantum readout techniques and technologies","grant_number":"862644","_id":"237CBA6C-32DE-11EA-91FC-C7463DDC885E","call_identifier":"H2020"}],"related_material":{"record":[{"status":"public","relation":"dissertation_contains","id":"12900"},{"id":"13175","relation":"dissertation_contains","status":"public"}]},"acknowledgement":"The authors thank S. Wald and F. Diorico for their help with optical filtering, O. Hosten\r\nand M. Aspelmeyer for equipment, H.G.L. Schwefel for materials and discussions, L.\r\nDrmic and P. Zielinski for software support, and the MIBA workshop at IST Austria for\r\nmachining the microwave cavity. This work was supported by the European Research\r\nCouncil under grant agreement no. 758053 (ERC StG QUNNECT) and the European\r\nUnion’s Horizon 2020 research and innovation program under grant agreement no.\r\n899354 (FETopen SuperQuLAN). W.H. is the recipient of an ISTplus postdoctoral fellowship\r\nwith funding from the European Union’s Horizon 2020 research and innovation\r\nprogram under the Marie Skłodowska-Curie grant agreement no. 754411. G.A. is the\r\nrecipient of a DOC fellowship of the Austrian Academy of Sciences at IST Austria. J.M.F.\r\nacknowledges support from the Austrian Science Fund (FWF) through BeyondC (F7105)\r\nand the European Union’s Horizon 2020 research and innovation programs under grant\r\nagreement no. 862644 (FETopen QUARTET).","ddc":["530"],"doi":"10.1038/s41467-022-28924-2","language":[{"iso":"eng"}],"title":"Quantum-enabled operation of a microwave-optical interface","citation":{"ama":"Sahu R, Hease WJ, Rueda Sanchez AR, Arnold GM, Qiu L, Fink JM. Quantum-enabled operation of a microwave-optical interface. <i>Nature Communications</i>. 2022;13. doi:<a href=\"https://doi.org/10.1038/s41467-022-28924-2\">10.1038/s41467-022-28924-2</a>","apa":"Sahu, R., Hease, W. J., Rueda Sanchez, A. R., Arnold, G. M., Qiu, L., &#38; Fink, J. M. (2022). Quantum-enabled operation of a microwave-optical interface. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-022-28924-2\">https://doi.org/10.1038/s41467-022-28924-2</a>","short":"R. Sahu, W.J. Hease, A.R. Rueda Sanchez, G.M. Arnold, L. Qiu, J.M. Fink, Nature Communications 13 (2022).","mla":"Sahu, Rishabh, et al. “Quantum-Enabled Operation of a Microwave-Optical Interface.” <i>Nature Communications</i>, vol. 13, 1276, Springer Nature, 2022, doi:<a href=\"https://doi.org/10.1038/s41467-022-28924-2\">10.1038/s41467-022-28924-2</a>.","chicago":"Sahu, Rishabh, William J Hease, Alfredo R Rueda Sanchez, Georg M Arnold, Liu Qiu, and Johannes M Fink. “Quantum-Enabled Operation of a Microwave-Optical Interface.” <i>Nature Communications</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1038/s41467-022-28924-2\">https://doi.org/10.1038/s41467-022-28924-2</a>.","ieee":"R. Sahu, W. J. Hease, A. R. Rueda Sanchez, G. M. Arnold, L. Qiu, and J. M. Fink, “Quantum-enabled operation of a microwave-optical interface,” <i>Nature Communications</i>, vol. 13. Springer Nature, 2022.","ista":"Sahu R, Hease WJ, Rueda Sanchez AR, Arnold GM, Qiu L, Fink JM. 2022. Quantum-enabled operation of a microwave-optical interface. Nature Communications. 13, 1276."},"ec_funded":1,"author":[{"last_name":"Sahu","first_name":"Rishabh","full_name":"Sahu, Rishabh","orcid":"0000-0001-6264-2162","id":"47D26E34-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Hease, William J","first_name":"William J","last_name":"Hease","orcid":"0000-0001-9868-2166","id":"29705398-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Alfredo R","full_name":"Rueda Sanchez, Alfredo R","last_name":"Rueda Sanchez","id":"3B82B0F8-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6249-5860"},{"id":"3770C838-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-1397-7876","last_name":"Arnold","first_name":"Georg M","full_name":"Arnold, Georg M"},{"orcid":"0000-0003-4345-4267","id":"45e99c0d-1eb1-11eb-9b96-ed8ab2983cac","last_name":"Qiu","full_name":"Qiu, Liu","first_name":"Liu"},{"first_name":"Johannes M","full_name":"Fink, Johannes M","last_name":"Fink","id":"4B591CBA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8112-028X"}],"type":"journal_article","day":"11","isi":1,"publisher":"Springer Nature","status":"public","intvolume":"        13","publication":"Nature Communications","department":[{"_id":"JoFi"}],"quality_controlled":"1","date_created":"2022-03-27T22:01:45Z","month":"03"},{"article_type":"original","year":"2022","oa_version":"Published Version","external_id":{"isi":["000763547000001"],"arxiv":["2201.04702"]},"scopus_import":"1","date_updated":"2023-08-03T06:20:26Z","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","publication_identifier":{"eissn":["1469-7645"],"issn":["0022-1120"]},"arxiv":1,"article_processing_charge":"No","article_number":"A39","_id":"10925","abstract":[{"text":"Direct numerical simulations (DNS) of turbulent channel flows up to  Reτ≈1000  are conducted to investigate the three-dimensional (consisting of streamwise wavenumber, spanwise wavenumber and frequency) spectrum of wall pressure fluctuations. To develop a predictive model of the wavenumber–frequency spectrum from the wavenumber spectrum, the time decorrelation mechanisms of wall pressure fluctuations are investigated. It is discovered that the energy-containing part of the wavenumber–frequency spectrum of wall pressure fluctuations can be well predicted using a similar random sweeping model for streamwise velocity fluctuations. To refine the investigation, we further decompose the spectrum of the total wall pressure fluctuations into the autospectra of rapid and slow pressure fluctuations, and the cross-spectrum between them. We focus on evaluating the assumption applied in many predictive models, that is, the magnitude of the cross-spectrum is negligibly small. The present DNS shows that neglecting the cross-spectrum causes a maximum error up to 4.7 dB in the subconvective region for all Reynolds numbers under test. Our analyses indicate that the approximation of neglecting the cross-spectrum needs to be applied carefully in the investigations of acoustics at low Mach numbers, in which the subconvective components of wall pressure fluctuations make important contributions to the radiated acoustic power.","lang":"eng"}],"date_published":"2022-04-25T00:00:00Z","publication_status":"published","oa":1,"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1017/jfm.2022.137"}],"volume":937,"citation":{"chicago":"Yang, Bowen, and Zixuan Yang. “On the Wavenumber-Frequency Spectrum of the Wall Pressure Fluctuations in Turbulent Channel Flow.” <i>Journal of Fluid Mechanics</i>. Cambridge University Press, 2022. <a href=\"https://doi.org/10.1017/jfm.2022.137\">https://doi.org/10.1017/jfm.2022.137</a>.","ieee":"B. Yang and Z. Yang, “On the wavenumber-frequency spectrum of the wall pressure fluctuations in turbulent channel flow,” <i>Journal of Fluid Mechanics</i>, vol. 937. Cambridge University Press, 2022.","ista":"Yang B, Yang Z. 2022. On the wavenumber-frequency spectrum of the wall pressure fluctuations in turbulent channel flow. Journal of Fluid Mechanics. 937, A39.","mla":"Yang, Bowen, and Zixuan Yang. “On the Wavenumber-Frequency Spectrum of the Wall Pressure Fluctuations in Turbulent Channel Flow.” <i>Journal of Fluid Mechanics</i>, vol. 937, A39, Cambridge University Press, 2022, doi:<a href=\"https://doi.org/10.1017/jfm.2022.137\">10.1017/jfm.2022.137</a>.","short":"B. Yang, Z. Yang, Journal of Fluid Mechanics 937 (2022).","ama":"Yang B, Yang Z. On the wavenumber-frequency spectrum of the wall pressure fluctuations in turbulent channel flow. <i>Journal of Fluid Mechanics</i>. 2022;937. doi:<a href=\"https://doi.org/10.1017/jfm.2022.137\">10.1017/jfm.2022.137</a>","apa":"Yang, B., &#38; Yang, Z. (2022). On the wavenumber-frequency spectrum of the wall pressure fluctuations in turbulent channel flow. <i>Journal of Fluid Mechanics</i>. Cambridge University Press. <a href=\"https://doi.org/10.1017/jfm.2022.137\">https://doi.org/10.1017/jfm.2022.137</a>"},"title":"On the wavenumber-frequency spectrum of the wall pressure fluctuations in turbulent channel flow","day":"25","author":[{"first_name":"Bowen","full_name":"Yang, Bowen","last_name":"Yang","orcid":"0000-0002-4843-6853","id":"71b6ff4b-15b2-11ec-abd3-aef6b028cf7e"},{"last_name":"Yang","first_name":"Zixuan","full_name":"Yang, Zixuan"}],"type":"journal_article","acknowledgement":"This research is supported by the NSFC Basic Science Center Program for ‘Multiscale Problems in Nonlinear Mechanics’ (no. 11988102), National Key Project (GJXM92579) and the Strategic Priority Research Program (XDB22040104).","language":[{"iso":"eng"}],"doi":"10.1017/jfm.2022.137","month":"04","date_created":"2022-03-27T22:01:45Z","publisher":"Cambridge University Press","isi":1,"publication":"Journal of Fluid Mechanics","department":[{"_id":"GradSch"}],"quality_controlled":"1","status":"public","intvolume":"       937"},{"title":"Very short mountings are enough for sperm transfer in Littorina saxatilis","citation":{"ista":"Perini S, Butlin R, Westram AM, Johannesson K. 2022. Very short mountings are enough for sperm transfer in Littorina saxatilis. Journal of Molluscan Studies. 88(1), eyab049.","ieee":"S. Perini, R. Butlin, A. M. Westram, and K. Johannesson, “Very short mountings are enough for sperm transfer in Littorina saxatilis,” <i>Journal of Molluscan Studies</i>, vol. 88, no. 1. Oxford Academic, 2022.","chicago":"Perini, Samuel, Rogerk Butlin, Anja M Westram, and Kerstin Johannesson. “Very Short Mountings Are Enough for Sperm Transfer in Littorina Saxatilis.” <i>Journal of Molluscan Studies</i>. Oxford Academic, 2022. <a href=\"https://doi.org/10.1093/mollus/eyab049\">https://doi.org/10.1093/mollus/eyab049</a>.","mla":"Perini, Samuel, et al. “Very Short Mountings Are Enough for Sperm Transfer in Littorina Saxatilis.” <i>Journal of Molluscan Studies</i>, vol. 88, no. 1, eyab049, Oxford Academic, 2022, doi:<a href=\"https://doi.org/10.1093/mollus/eyab049\">10.1093/mollus/eyab049</a>.","short":"S. Perini, R. Butlin, A.M. Westram, K. Johannesson, Journal of Molluscan Studies 88 (2022).","apa":"Perini, S., Butlin, R., Westram, A. M., &#38; Johannesson, K. (2022). Very short mountings are enough for sperm transfer in Littorina saxatilis. <i>Journal of Molluscan Studies</i>. Oxford Academic. <a href=\"https://doi.org/10.1093/mollus/eyab049\">https://doi.org/10.1093/mollus/eyab049</a>","ama":"Perini S, Butlin R, Westram AM, Johannesson K. Very short mountings are enough for sperm transfer in Littorina saxatilis. <i>Journal of Molluscan Studies</i>. 2022;88(1). doi:<a href=\"https://doi.org/10.1093/mollus/eyab049\">10.1093/mollus/eyab049</a>"},"author":[{"last_name":"Perini","full_name":"Perini, Samuel","first_name":"Samuel"},{"last_name":"Butlin","first_name":"Rogerk","full_name":"Butlin, Rogerk"},{"full_name":"Westram, Anja M","first_name":"Anja M","last_name":"Westram","id":"3C147470-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-1050-4969"},{"first_name":"Kerstin","full_name":"Johannesson, Kerstin","last_name":"Johannesson"}],"type":"journal_article","day":"01","doi":"10.1093/mollus/eyab049","language":[{"iso":"eng"}],"date_created":"2022-03-27T22:01:46Z","month":"03","isi":1,"publisher":"Oxford Academic","intvolume":"        88","status":"public","department":[{"_id":"BeVi"}],"quality_controlled":"1","publication":"Journal of Molluscan Studies","year":"2022","oa_version":"Submitted Version","article_type":"original","publication_identifier":{"eissn":["1464-3766"],"issn":["0260-1230"]},"date_updated":"2023-08-03T06:23:13Z","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","external_id":{"isi":["000759081600002"]},"scopus_import":"1","issue":"1","article_processing_charge":"No","date_published":"2022-03-01T00:00:00Z","_id":"10926","abstract":[{"lang":"eng","text":"Conflict over reproduction between females and males exists because of anisogamy and promiscuity. Together they generate differences in fitness optima between the sexes and result in antagonistic coevolution of female and male reproductive traits. Mounting duration is likely to be a compromise between male and female interests whose outcome depends on the intensity of sexual selection. The timing of sperm transfer during mounting is critical. For example, mountings may be interrupted before sperm is transferred as a consequence of female or male choice, or they may be prolonged to function as mate guarding. In the highly promiscuous intertidal snail Littorina saxatilis, mountings vary substantially in duration, from less than a minute to more than an hour, and it has been assumed that mountings of a few minutes do not result in any sperm being transferred. Here, we examined the timing of sperm transfer, a reproductive trait that is likely affected by sexual conflict. We performed time-controlled mounting trials using L. saxatilis males and virgin females, aiming to examine indirectly when the transfer of sperm starts. We observed the relationship between mounting duration and the proportion of developing embryos out of all eggs and embryos in the brood pouch. Developing embryos were observed in similar proportions in all treatments (i.e. 1, 5 and 10 or more minutes at which mountings were artificially interrupted), suggesting that sperm transfer begins rapidly (within 1 min) in L. saxatilis and very short matings do not result in sperm shortage in the females. We discuss how the observed pattern can be influenced by predation risk, population density, and female status and receptivity."}],"article_number":"eyab049","oa":1,"main_file_link":[{"url":"https://eprints.whiterose.ac.uk/187332/","open_access":"1"}],"publication_status":"published","volume":88},{"title":"PaReBrick: PArallel REarrangements and BReaks identification toolkit","citation":{"chicago":"Zabelkin, Alexey, Yulia Yakovleva, Olga Bochkareva, and Nikita Alexeev. “PaReBrick: PArallel REarrangements and BReaks Identification Toolkit.” <i>Bioinformatics</i>. Oxford Academic, 2022. <a href=\"https://doi.org/10.1093/bioinformatics/btab691\">https://doi.org/10.1093/bioinformatics/btab691</a>.","ieee":"A. Zabelkin, Y. Yakovleva, O. Bochkareva, and N. Alexeev, “PaReBrick: PArallel REarrangements and BReaks identification toolkit,” <i>Bioinformatics</i>, vol. 38, no. 2. Oxford Academic, pp. 357–363, 2022.","ista":"Zabelkin A, Yakovleva Y, Bochkareva O, Alexeev N. 2022. PaReBrick: PArallel REarrangements and BReaks identification toolkit. Bioinformatics. 38(2), 357–363.","mla":"Zabelkin, Alexey, et al. “PaReBrick: PArallel REarrangements and BReaks Identification Toolkit.” <i>Bioinformatics</i>, vol. 38, no. 2, Oxford Academic, 2022, pp. 357–63, doi:<a href=\"https://doi.org/10.1093/bioinformatics/btab691\">10.1093/bioinformatics/btab691</a>.","short":"A. Zabelkin, Y. Yakovleva, O. Bochkareva, N. Alexeev, Bioinformatics 38 (2022) 357–363.","ama":"Zabelkin A, Yakovleva Y, Bochkareva O, Alexeev N. PaReBrick: PArallel REarrangements and BReaks identification toolkit. <i>Bioinformatics</i>. 2022;38(2):357-363. doi:<a href=\"https://doi.org/10.1093/bioinformatics/btab691\">10.1093/bioinformatics/btab691</a>","apa":"Zabelkin, A., Yakovleva, Y., Bochkareva, O., &#38; Alexeev, N. (2022). PaReBrick: PArallel REarrangements and BReaks identification toolkit. <i>Bioinformatics</i>. Oxford Academic. <a href=\"https://doi.org/10.1093/bioinformatics/btab691\">https://doi.org/10.1093/bioinformatics/btab691</a>"},"ec_funded":1,"type":"journal_article","author":[{"last_name":"Zabelkin","full_name":"Zabelkin, Alexey","first_name":"Alexey"},{"first_name":"Yulia","full_name":"Yakovleva, Yulia","last_name":"Yakovleva"},{"id":"C4558D3C-6102-11E9-A62E-F418E6697425","orcid":"0000-0003-1006-6639","first_name":"Olga","full_name":"Bochkareva, Olga","last_name":"Bochkareva"},{"last_name":"Alexeev","first_name":"Nikita","full_name":"Alexeev, Nikita"}],"day":"15","related_material":{"link":[{"url":"https://github.com/ctlab/parallel-rearrangements","relation":"software"}]},"project":[{"_id":"260C2330-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"754411","name":"ISTplus - Postdoctoral Fellowships"}],"acknowledgement":"The authors thank the 2020 student class of the Bioinformatics Institute, who\r\nused the first versions of the tool and provided many valuable suggestions to\r\nimprove usability. They also thank Louisa Gonzalez Somermeyer for manuscript proofreading\r\nThis work was supported by the National Center for Cognitive Research of\r\nITMO University and JetBrains Research [to A.Z and N.A.]; and the European\r\nUnion’s Horizon 2020 Research and Innovation Programme under the Marie\r\nSkłodowska-Curie [754411 to O.B.].\r\nPaReBrick is written in Python and is available on GitHub: https://github.com/ctlab/parallel-rearrangements.","doi":"10.1093/bioinformatics/btab691","ddc":["000"],"language":[{"iso":"eng"}],"page":"357-363","date_created":"2022-03-27T22:01:46Z","month":"01","isi":1,"publisher":"Oxford Academic","intvolume":"        38","status":"public","publication":"Bioinformatics","department":[{"_id":"FyKo"}],"quality_controlled":"1","oa_version":"Published Version","year":"2022","has_accepted_license":"1","article_type":"original","publication_identifier":{"issn":["1367-4803"],"eissn":["1460-2059"]},"external_id":{"isi":["000743380100008"]},"scopus_import":"1","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","date_updated":"2023-08-03T06:21:46Z","article_processing_charge":"No","issue":"2","_id":"10927","date_published":"2022-01-15T00:00:00Z","abstract":[{"text":"Motivation\r\nHigh plasticity of bacterial genomes is provided by numerous mechanisms including horizontal gene transfer and recombination via numerous flanking repeats. Genome rearrangements such as inversions, deletions, insertions and duplications may independently occur in different strains, providing parallel adaptation or phenotypic diversity. Specifically, such rearrangements might be responsible for virulence, antibiotic resistance and antigenic variation. However, identification of such events requires laborious manual inspection and verification of phyletic pattern consistency.\r\nResults\r\nHere, we define the term ‘parallel rearrangements’ as events that occur independently in phylogenetically distant bacterial strains and present a formalization of the problem of parallel rearrangements calling. We implement an algorithmic solution for the identification of parallel rearrangements in bacterial populations as a tool PaReBrick. The tool takes a collection of strains represented as a sequence of oriented synteny blocks and a phylogenetic tree as input data. It identifies rearrangements, tests them for consistency with a tree, and sorts the events by their parallelism score. The tool provides diagrams of the neighbors for each block of interest, allowing the detection of horizontally transferred blocks or their extra copies and the inversions in which copied blocks are involved. We demonstrated PaReBrick’s efficiency and accuracy and showed its potential to detect genome rearrangements responsible for pathogenicity and adaptation in bacterial genomes.","lang":"eng"}],"file":[{"date_created":"2022-03-28T08:07:46Z","success":1,"content_type":"application/pdf","file_id":"10930","relation":"main_file","checksum":"4b5688ff9ac86180ccdf7f82fa33d926","date_updated":"2022-03-28T08:07:46Z","access_level":"open_access","file_name":"2022_Bioinformatics_Zabelkin.pdf","creator":"dernst","file_size":3425744}],"oa":1,"publication_status":"published","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"volume":38,"file_date_updated":"2022-03-28T08:07:46Z"},{"acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2024-02-21T12:35:18Z","oa_version":"Submitted Version","year":"2022","has_accepted_license":"1","contributor":[{"last_name":"Loose","first_name":"Martin","id":"462D4284-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-7309-9724","contributor_type":"supervisor"},{"last_name":"Sommer","first_name":"Christoph M","id":"4DF26D8C-F248-11E8-B48F-1D18A9856A87","contributor_type":"researcher"},{"first_name":"Paulo","last_name":"Caldas","contributor_type":"researcher"},{"contributor_type":"researcher","id":"B9577E20-AA38-11E9-AC9A-0930E6697425","first_name":"David","last_name":"Michalik"},{"contributor_type":"researcher","first_name":"Natalia","last_name":"Baranova"}],"oa":1,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"file_date_updated":"2022-04-22T10:15:19Z","article_processing_charge":"No","date_published":"2022-04-05T00:00:00Z","_id":"10934","abstract":[{"lang":"eng","text":"FtsA is crucial for assembly of the E. coli divisome, as it dynamically links cytoplasmic FtsZ filaments with transmembrane cell division proteins. FtsA allegedly initiates cell division by switching from an inactive polymeric to an active monomeric confirmation, which recruits downstream proteins and stabilizes FtsZ filaments. Here, we use biochemical reconstitution experiments combined with quantitative fluorescence microscopy to study divisome activation in vitro. We compare wildtype-FtsA with FtsA-R286W, a constantly active gain-of-function mutant and find that R286W outperforms the wildtype protein in replicating FtsZ treadmilling dynamics, stabilizing FtsZ filaments and recruiting FtsN. We attribute these differences to a faster membrane exchange of FtsA-R286W and its higher packing density below FtsZ filaments.  Using FRET microscopy, we find that FtsN binding does not compete with, but promotes FtsA self-interaction. Our findings suggest a model where FtsA always forms dynamic polymers on the membrane, which re-organize during assembly and activation of the divisome. 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FtsZ_01.z01","date_created":"2022-04-05T08:51:55Z","success":1,"file_id":"10953","relation":"main_file","content_type":"application/octet-stream"}],"acknowledgement":"We acknowledge members of the Loose laboratory at IST Austria for helpful discussions—in particular L. Lindorfer for his assistance with cloning and purifications. We thank J. Löwe and T. Nierhaus (MRC-LMB Cambridge, UK) for sharing unpublished work and helpful discussions, as well as D. Vavylonis and D. Rutkowski (Lehigh University, Bethlehem, PA, USA) as well as S. Martin (University of Lausanne, Switzerland) for sharing their code for FRAP analysis. We are also thankful for the support by the Scientific Service Units (SSU) of IST Austria through resources provided by the Imaging and Optics Facility (IOF) and the Lab Support Facility (LSF). This work was supported by the European Research Council through grant ERC 2015-StG-679239 and by the Austrian Science Fund (FWF) StandAlone P34607 to M.L. and HFSP LT 000824/2016-L4 to N.B. For the purpose of open access, we have applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission.","related_material":{"record":[{"status":"public","id":"11373","relation":"used_in_publication"},{"status":"public","id":"14280","relation":"used_in_publication"}],"link":[{"description":"A custom written code (FRAPdiff) to quantify the Off binding rate and Diffusion coefficient of membrane bound proteins. Written by Christoph Sommer.","url":"https://doi.org/10.5281/zenodo.6400639","relation":"software"}]},"project":[{"name":"Self-Organization of the Bacterial Cell","grant_number":"679239","_id":"2595697A-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"},{"_id":"fc38323b-9c52-11eb-aca3-ff8afb4a011d","name":"Understanding bacterial cell division by in vitro\r\nreconstitution","grant_number":"P34607"}],"ddc":["572"],"doi":"10.15479/AT:ISTA:10934","keyword":["Bacterial cell division","in vitro reconstitution","FtsZ","FtsN","FtsA"],"title":"In vitro reconstitution of Escherichia coli divisome activation","ec_funded":1,"citation":{"apa":"Radler, P. (2022). In vitro reconstitution of Escherichia coli divisome activation. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:10934\">https://doi.org/10.15479/AT:ISTA:10934</a>","ama":"Radler P. In vitro reconstitution of Escherichia coli divisome activation. 2022. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:10934\">10.15479/AT:ISTA:10934</a>","short":"P. Radler, (2022).","mla":"Radler, Philipp. <i>In Vitro Reconstitution of Escherichia Coli Divisome Activation</i>. Institute of Science and Technology Austria, 2022, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:10934\">10.15479/AT:ISTA:10934</a>.","ista":"Radler P. 2022. In vitro reconstitution of Escherichia coli divisome activation, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:10934\">10.15479/AT:ISTA:10934</a>.","ieee":"P. Radler, “In vitro reconstitution of Escherichia coli divisome activation.” Institute of Science and Technology Austria, 2022.","chicago":"Radler, Philipp. “In Vitro Reconstitution of Escherichia Coli Divisome Activation.” Institute of Science and Technology Austria, 2022. <a href=\"https://doi.org/10.15479/AT:ISTA:10934\">https://doi.org/10.15479/AT:ISTA:10934</a>."},"author":[{"last_name":"Radler","first_name":"Philipp","full_name":"Radler, Philipp","orcid":" 0000-0001-9198-2182 ","id":"40136C2A-F248-11E8-B48F-1D18A9856A87"}],"type":"research_data","day":"05","publisher":"Institute of Science and Technology Austria","status":"public","department":[{"_id":"GradSch"},{"_id":"MaLo"}],"date_created":"2022-03-31T11:32:32Z","month":"04"},{"day":"18","author":[{"first_name":"Anđela","full_name":"Davidović, Anđela","last_name":"Davidović"},{"id":"3464AE84-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-0876-3187","last_name":"Chait","first_name":"Remy P","full_name":"Chait, Remy P"},{"full_name":"Batt, Gregory","first_name":"Gregory","last_name":"Batt"},{"id":"4A245D00-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-1615-3282","last_name":"Ruess","first_name":"Jakob","full_name":"Ruess, Jakob"}],"type":"journal_article","citation":{"mla":"Davidović, Anđela, et al. “Parameter Inference for Stochastic Biochemical Models from Perturbation Experiments Parallelised at the Single Cell Level.” <i>PLoS Computational Biology</i>, vol. 18, no. 3, e1009950, Public Library of Science, 2022, doi:<a href=\"https://doi.org/10.1371/journal.pcbi.1009950\">10.1371/journal.pcbi.1009950</a>.","ieee":"A. Davidović, R. P. Chait, G. Batt, and J. Ruess, “Parameter inference for stochastic biochemical models from perturbation experiments parallelised at the single cell level,” <i>PLoS Computational Biology</i>, vol. 18, no. 3. Public Library of Science, 2022.","ista":"Davidović A, Chait RP, Batt G, Ruess J. 2022. Parameter inference for stochastic biochemical models from perturbation experiments parallelised at the single cell level. PLoS Computational Biology. 18(3), e1009950.","chicago":"Davidović, Anđela, Remy P Chait, Gregory Batt, and Jakob Ruess. “Parameter Inference for Stochastic Biochemical Models from Perturbation Experiments Parallelised at the Single Cell Level.” <i>PLoS Computational Biology</i>. Public Library of Science, 2022. <a href=\"https://doi.org/10.1371/journal.pcbi.1009950\">https://doi.org/10.1371/journal.pcbi.1009950</a>.","apa":"Davidović, A., Chait, R. P., Batt, G., &#38; Ruess, J. (2022). Parameter inference for stochastic biochemical models from perturbation experiments parallelised at the single cell level. <i>PLoS Computational Biology</i>. Public Library of Science. <a href=\"https://doi.org/10.1371/journal.pcbi.1009950\">https://doi.org/10.1371/journal.pcbi.1009950</a>","ama":"Davidović A, Chait RP, Batt G, Ruess J. Parameter inference for stochastic biochemical models from perturbation experiments parallelised at the single cell level. <i>PLoS Computational Biology</i>. 2022;18(3). doi:<a href=\"https://doi.org/10.1371/journal.pcbi.1009950\">10.1371/journal.pcbi.1009950</a>","short":"A. Davidović, R.P. Chait, G. Batt, J. Ruess, PLoS Computational Biology 18 (2022)."},"title":"Parameter inference for stochastic biochemical models from perturbation experiments parallelised at the single cell level","language":[{"iso":"eng"}],"doi":"10.1371/journal.pcbi.1009950","ddc":["570","000"],"related_material":{"link":[{"url":"https://gitlab.pasteur.fr/adavidov/inferencelnakf","relation":"software"}]},"acknowledgement":"We thank Virgile Andreani for useful discussions about the model and parameter inference. We thank Johan Paulsson and Jeffrey J Tabor for kind gifts of plasmids. R was supported by the ANR grant CyberCircuits (ANR-18-CE91-0002). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","month":"03","date_created":"2022-04-03T22:01:42Z","publication":"PLoS Computational Biology","department":[{"_id":"CaGu"}],"quality_controlled":"1","status":"public","intvolume":"        18","publisher":"Public Library of Science","article_type":"original","oa_version":"Published Version","has_accepted_license":"1","year":"2022","scopus_import":"1","date_updated":"2022-04-04T10:21:53Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"eissn":["1553-7358"],"issn":["1553-734X"]},"file":[{"file_name":"2022_PLoSCompBio_Davidovic.pdf","creator":"dernst","file_size":2958642,"checksum":"458ef542761fb714ced214f240daf6b2","date_updated":"2022-04-04T10:14:39Z","access_level":"open_access","content_type":"application/pdf","relation":"main_file","file_id":"10947","date_created":"2022-04-04T10:14:39Z","success":1}],"article_number":"e1009950","date_published":"2022-03-18T00:00:00Z","_id":"10939","abstract":[{"text":"Understanding and characterising biochemical processes inside single cells requires experimental platforms that allow one to perturb and observe the dynamics of such processes as well as computational methods to build and parameterise models from the collected data. Recent progress with experimental platforms and optogenetics has made it possible to expose each cell in an experiment to an individualised input and automatically record cellular responses over days with fine time resolution. However, methods to infer parameters of stochastic kinetic models from single-cell longitudinal data have generally been developed under the assumption that experimental data is sparse and that responses of cells to at most a few different input perturbations can be observed. Here, we investigate and compare different approaches for calculating parameter likelihoods of single-cell longitudinal data based on approximations of the chemical master equation (CME) with a particular focus on coupling the linear noise approximation (LNA) or moment closure methods to a Kalman filter. We show that, as long as cells are measured sufficiently frequently, coupling the LNA to a Kalman filter allows one to accurately approximate likelihoods and to infer model parameters from data even in cases where the LNA provides poor approximations of the CME. Furthermore, the computational cost of filtering-based iterative likelihood evaluation scales advantageously in the number of measurement times and different input perturbations and is thus ideally suited for data obtained from modern experimental platforms. To demonstrate the practical usefulness of these results, we perform an experiment in which single cells, equipped with an optogenetic gene expression system, are exposed to various different light-input sequences and measured at several hundred time points and use parameter inference based on iterative likelihood evaluation to parameterise a stochastic model of the system.","lang":"eng"}],"article_processing_charge":"No","issue":"3","file_date_updated":"2022-04-04T10:14:39Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"volume":18,"publication_status":"published","oa":1},{"arxiv":1,"issue":"3","article_processing_charge":"No","article_number":"034032","date_published":"2022-03-11T00:00:00Z","_id":"10940","abstract":[{"lang":"eng","text":"Magnetic-field-resilient superconducting circuits enable sensing applications and hybrid quantum computing architectures involving spin or topological qubits and electromechanical elements, as well as studying flux noise and quasiparticle loss. We investigate the effect of in-plane magnetic fields up to 1 T on the spectrum and coherence times of thin-film three-dimensional aluminum transmons. Using a copper cavity, unaffected by strong magnetic fields, we can probe solely the effect of magnetic fields on the transmons. We present data on a single-junction and a superconducting-quantum-interference-device (SQUID) transmon that are cooled down in the same cavity. As expected, the transmon frequencies decrease with increasing field, due to suppression of the superconducting gap and a geometric Fraunhofer-like contribution. Nevertheless, the thin-film transmons show strong magnetic field resilience: both transmons display microsecond coherence up to at least 0.65 T, and T1 remains above 1μs over the entire measurable range. SQUID spectroscopy is feasible up to 1 T, the limit of our magnet. We conclude that thin-film aluminum Josephson junctions are suitable hardware for superconducting circuits in the high-magnetic-field regime."}],"publication_status":"published","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2111.01115"}],"oa":1,"volume":17,"article_type":"original","oa_version":"Preprint","year":"2022","date_updated":"2023-08-03T06:23:58Z","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","external_id":{"isi":["000770371400003"],"arxiv":["2111.01115"]},"scopus_import":"1","publication_identifier":{"eissn":["2331-7019"]},"month":"03","date_created":"2022-04-03T22:01:43Z","publisher":"American Physical Society","isi":1,"department":[{"_id":"JoFi"}],"quality_controlled":"1","publication":"Physical Review Applied","intvolume":"        17","status":"public","citation":{"short":"J. Krause, C. Dickel, E. Vaal, M. Vielmetter, J. Feng, R. Bounds, G. Catelani, J.M. Fink, Y. Ando, Physical Review Applied 17 (2022).","apa":"Krause, J., Dickel, C., Vaal, E., Vielmetter, M., Feng, J., Bounds, R., … Ando, Y. (2022). Magnetic field resilience of three-dimensional transmons with thin-film Al/AlOx/Al Josephson junctions approaching 1 T. <i>Physical Review Applied</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevApplied.17.034032\">https://doi.org/10.1103/PhysRevApplied.17.034032</a>","ama":"Krause J, Dickel C, Vaal E, et al. Magnetic field resilience of three-dimensional transmons with thin-film Al/AlOx/Al Josephson junctions approaching 1 T. <i>Physical Review Applied</i>. 2022;17(3). doi:<a href=\"https://doi.org/10.1103/PhysRevApplied.17.034032\">10.1103/PhysRevApplied.17.034032</a>","ista":"Krause J, Dickel C, Vaal E, Vielmetter M, Feng J, Bounds R, Catelani G, Fink JM, Ando Y. 2022. Magnetic field resilience of three-dimensional transmons with thin-film Al/AlOx/Al Josephson junctions approaching 1 T. Physical Review Applied. 17(3), 034032.","ieee":"J. Krause <i>et al.</i>, “Magnetic field resilience of three-dimensional transmons with thin-film Al/AlOx/Al Josephson junctions approaching 1 T,” <i>Physical Review Applied</i>, vol. 17, no. 3. American Physical Society, 2022.","chicago":"Krause, J., C. Dickel, E. Vaal, M. Vielmetter, J. Feng, R. Bounds, G. Catelani, Johannes M Fink, and Yoichi Ando. “Magnetic Field Resilience of Three-Dimensional Transmons with Thin-Film Al/AlOx/Al Josephson Junctions Approaching 1 T.” <i>Physical Review Applied</i>. American Physical Society, 2022. <a href=\"https://doi.org/10.1103/PhysRevApplied.17.034032\">https://doi.org/10.1103/PhysRevApplied.17.034032</a>.","mla":"Krause, J., et al. “Magnetic Field Resilience of Three-Dimensional Transmons with Thin-Film Al/AlOx/Al Josephson Junctions Approaching 1 T.” <i>Physical Review Applied</i>, vol. 17, no. 3, 034032, American Physical Society, 2022, doi:<a href=\"https://doi.org/10.1103/PhysRevApplied.17.034032\">10.1103/PhysRevApplied.17.034032</a>."},"title":"Magnetic field resilience of three-dimensional transmons with thin-film Al/AlOx/Al Josephson junctions approaching 1 T","day":"11","type":"journal_article","author":[{"last_name":"Krause","first_name":"J.","full_name":"Krause, J."},{"full_name":"Dickel, C.","first_name":"C.","last_name":"Dickel"},{"last_name":"Vaal","full_name":"Vaal, E.","first_name":"E."},{"full_name":"Vielmetter, M.","first_name":"M.","last_name":"Vielmetter"},{"last_name":"Feng","first_name":"J.","full_name":"Feng, J."},{"last_name":"Bounds","first_name":"R.","full_name":"Bounds, R."},{"last_name":"Catelani","first_name":"G.","full_name":"Catelani, G."},{"orcid":"0000-0001-8112-028X","id":"4B591CBA-F248-11E8-B48F-1D18A9856A87","full_name":"Fink, Johannes M","first_name":"Johannes M","last_name":"Fink"},{"full_name":"Ando, Yoichi","first_name":"Yoichi","last_name":"Ando"}],"acknowledgement":"We would like to thank Ida Milow for her internship in the laboratory and contributions to our code base. We thank T. Zent and L. Hamdan for technical assistance, and D. Fan for help with setting up the aluminum evaporator. We thank A. Salari, M. Rößler, S. Barzanjeh, M. Zemlicka, F. Hassani, and M. Peruzzo for contributions in the early stages of the experiments. This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (Grant Agreement No. 741121) and was also funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under CRC 1238 – 277146847 (Subproject B01), as well as under Germany’s Excellence Strategy – Cluster of Excellence Matter and Light for Quantum Computing (ML4Q), EXC 2004/1\r\n– 390534769.","language":[{"iso":"eng"}],"doi":"10.1103/PhysRevApplied.17.034032"},{"month":"04","date_created":"2022-04-04T09:03:54Z","page":"149-164","publication":"Colorants","quality_controlled":"1","department":[{"_id":"LeSa"}],"status":"public","intvolume":"         1","publisher":"MDPI","day":"01","author":[{"last_name":"Çoruh","first_name":"Mehmet Orkun","full_name":"Çoruh, Mehmet Orkun","id":"d25163e5-8d53-11eb-a251-e6dd8ea1b8ef","orcid":"0000-0002-3219-2022"},{"last_name":"Gündüz","first_name":"Güngör","full_name":"Gündüz, Güngör"},{"first_name":"Üner","full_name":"Çolak, Üner","last_name":"Çolak"},{"last_name":"Maviş","first_name":"Bora","full_name":"Maviş, Bora"}],"type":"journal_article","citation":{"apa":"Çoruh, M. O., Gündüz, G., Çolak, Ü., &#38; Maviş, B. (2022). pH-dependent coloring of combination effect pigments with anthocyanins from Brassica oleracea var. capitata F. rubra. <i>Colorants</i>. MDPI. <a href=\"https://doi.org/10.3390/colorants1020010\">https://doi.org/10.3390/colorants1020010</a>","ama":"Çoruh MO, Gündüz G, Çolak Ü, Maviş B. pH-dependent coloring of combination effect pigments with anthocyanins from Brassica oleracea var. capitata F. rubra. <i>Colorants</i>. 2022;1(2):149-164. doi:<a href=\"https://doi.org/10.3390/colorants1020010\">10.3390/colorants1020010</a>","short":"M.O. Çoruh, G. Gündüz, Ü. Çolak, B. Maviş, Colorants 1 (2022) 149–164.","mla":"Çoruh, Mehmet Orkun, et al. “PH-Dependent Coloring of Combination Effect Pigments with Anthocyanins from Brassica Oleracea Var. Capitata F. Rubra.” <i>Colorants</i>, vol. 1, no. 2, MDPI, 2022, pp. 149–64, doi:<a href=\"https://doi.org/10.3390/colorants1020010\">10.3390/colorants1020010</a>.","ista":"Çoruh MO, Gündüz G, Çolak Ü, Maviş B. 2022. pH-dependent coloring of combination effect pigments with anthocyanins from Brassica oleracea var. capitata F. rubra. Colorants. 1(2), 149–164.","ieee":"M. O. Çoruh, G. Gündüz, Ü. Çolak, and B. Maviş, “pH-dependent coloring of combination effect pigments with anthocyanins from Brassica oleracea var. capitata F. rubra,” <i>Colorants</i>, vol. 1, no. 2. MDPI, pp. 149–164, 2022.","chicago":"Çoruh, Mehmet Orkun, Güngör Gündüz, Üner Çolak, and Bora Maviş. “PH-Dependent Coloring of Combination Effect Pigments with Anthocyanins from Brassica Oleracea Var. Capitata F. Rubra.” <i>Colorants</i>. MDPI, 2022. <a href=\"https://doi.org/10.3390/colorants1020010\">https://doi.org/10.3390/colorants1020010</a>."},"title":"pH-dependent coloring of combination effect pigments with anthocyanins from Brassica oleracea var. capitata F. rubra","language":[{"iso":"eng"}],"doi":"10.3390/colorants1020010","ddc":["570"],"acknowledgement":"This research was partly funded by Hacettepe University (Bilimsel Ara¸stırma Projeleri\r\nKoordinasyon Birimi), grant number FHD-2015-8094.The authors are indebted to Ahmet Önal for his supports in acquiring the fluorescence spectra and the decision of excitation wavelengths. The authors also acknowledge use of the services and facilities of UNAM-National Nanotechnology Research Center at Bilkent University and mica donation from Sabuncular Mining Co.","file":[{"date_created":"2022-04-04T10:39:24Z","success":1,"file_id":"10949","relation":"main_file","content_type":"application/pdf","checksum":"2c15c8d3041ebc36bc64870247081758","access_level":"open_access","date_updated":"2022-04-04T10:39:24Z","file_size":2437988,"creator":"dernst","file_name":"2022_Colorants_Coruh.pdf"}],"abstract":[{"lang":"eng","text":"Mica-titania pearlescent pigments (MTs) were previously coated with organic molecules to obtain combination pigments (CPs) for achieving certain improvements or functionalities. Anthocyanins (ACNs) are molecules that can be extracted from natural resources and exhibit color changes via pH modifications of the enclosing medium. The purpose of the study was to produce a new series of CPs by depositing ACNs on MTs at different pH values, to observe the changes in color, and to associate these changes to thermogravimetrically determined deposition efficiencies in light of spectral differences. The extraction and deposition methods were based on aqueous chemistry and were straightforward. The ACN deposition generally increased with increasing pH and correlated with the consistency between the charges of the MT surfaces and the dominant ACN species at a specific pH value. The fluorescence of the CPs was inversely correlated with the deposition quantities invoking the possibility of a quenching effect."}],"_id":"10945","date_published":"2022-04-01T00:00:00Z","article_processing_charge":"Yes","issue":"2","file_date_updated":"2022-04-04T10:39:24Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"volume":1,"publication_status":"published","oa":1,"article_type":"original","oa_version":"Published Version","year":"2022","has_accepted_license":"1","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","date_updated":"2023-08-09T10:12:22Z","publication_identifier":{"issn":["2079-6447"]}},{"scopus_import":"1","external_id":{"pmid":["34782239"]},"user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","date_updated":"2022-07-18T08:58:33Z","publication_identifier":{"issn":["0962-8924"]},"article_type":"review","year":"2022","oa_version":"None","publication_status":"published","volume":32,"article_processing_charge":"No","issue":"3","abstract":[{"text":"Nuclear pore complexes (NPCs) bridge the nucleus and the cytoplasm and are indispensable for crucial cellular activities, such as bidirectional molecular trafficking and gene transcription regulation. The discovery of long-lived proteins (LLPs) in NPCs from postmitotic cells raises the exciting possibility that the maintenance of NPC integrity might play an inherent role in lifelong cell function. Age-dependent deterioration of NPCs and loss of nuclear integrity have been linked to age-related decline in postmitotic cell function and degenerative diseases. In this review, we discuss our current understanding of NPC maintenance in proliferating and postmitotic cells, and how malfunction of nucleoporins (Nups) might contribute to the pathogenesis of various neurodegenerative and cardiovascular diseases.","lang":"eng"}],"_id":"11051","date_published":"2022-03-01T00:00:00Z","pmid":1,"keyword":["Cell Biology"],"language":[{"iso":"eng"}],"doi":"10.1016/j.tcb.2021.10.001","citation":{"short":"J. Liu, M. Hetzer, Trends in Cell Biology 32 (2022) P216-227.","ama":"Liu J, Hetzer M. Nuclear pore complex maintenance and implications for age-related diseases. <i>Trends in Cell Biology</i>. 2022;32(3):P216-227. doi:<a href=\"https://doi.org/10.1016/j.tcb.2021.10.001\">10.1016/j.tcb.2021.10.001</a>","apa":"Liu, J., &#38; Hetzer, M. (2022). Nuclear pore complex maintenance and implications for age-related diseases. <i>Trends in Cell Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.tcb.2021.10.001\">https://doi.org/10.1016/j.tcb.2021.10.001</a>","chicago":"Liu, Jinqiang, and Martin Hetzer. “Nuclear Pore Complex Maintenance and Implications for Age-Related Diseases.” <i>Trends in Cell Biology</i>. Elsevier, 2022. <a href=\"https://doi.org/10.1016/j.tcb.2021.10.001\">https://doi.org/10.1016/j.tcb.2021.10.001</a>.","ieee":"J. Liu and M. Hetzer, “Nuclear pore complex maintenance and implications for age-related diseases,” <i>Trends in Cell Biology</i>, vol. 32, no. 3. Elsevier, pp. P216-227, 2022.","ista":"Liu J, Hetzer M. 2022. Nuclear pore complex maintenance and implications for age-related diseases. Trends in Cell Biology. 32(3), P216-227.","mla":"Liu, Jinqiang, and Martin Hetzer. “Nuclear Pore Complex Maintenance and Implications for Age-Related Diseases.” <i>Trends in Cell Biology</i>, vol. 32, no. 3, Elsevier, 2022, pp. P216-227, doi:<a href=\"https://doi.org/10.1016/j.tcb.2021.10.001\">10.1016/j.tcb.2021.10.001</a>."},"title":"Nuclear pore complex maintenance and implications for age-related diseases","day":"01","author":[{"last_name":"Liu","first_name":"Jinqiang","full_name":"Liu, Jinqiang"},{"id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","orcid":"0000-0002-2111-992X","first_name":"Martin W","full_name":"HETZER, Martin W","last_name":"HETZER"}],"type":"journal_article","publisher":"Elsevier","publication":"Trends in Cell Biology","quality_controlled":"1","intvolume":"        32","status":"public","page":"P216-227","month":"03","extern":"1","date_created":"2022-04-07T07:43:01Z"},{"doi":"10.15479/at:ista:11128","ddc":["576","582"],"language":[{"iso":"eng"}],"title":"Genetic basis of flower colour as a model for adaptive evolution","citation":{"ama":"Matejovicova L. Genetic basis of flower colour as a model for adaptive evolution. 2022. doi:<a href=\"https://doi.org/10.15479/at:ista:11128\">10.15479/at:ista:11128</a>","apa":"Matejovicova, L. (2022). <i>Genetic basis of flower colour as a model for adaptive evolution</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/at:ista:11128\">https://doi.org/10.15479/at:ista:11128</a>","short":"L. Matejovicova, Genetic Basis of Flower Colour as a Model for Adaptive Evolution, Institute of Science and Technology Austria, 2022.","mla":"Matejovicova, Lenka. <i>Genetic Basis of Flower Colour as a Model for Adaptive Evolution</i>. Institute of Science and Technology Austria, 2022, doi:<a href=\"https://doi.org/10.15479/at:ista:11128\">10.15479/at:ista:11128</a>.","chicago":"Matejovicova, Lenka. “Genetic Basis of Flower Colour as a Model for Adaptive Evolution.” Institute of Science and Technology Austria, 2022. <a href=\"https://doi.org/10.15479/at:ista:11128\">https://doi.org/10.15479/at:ista:11128</a>.","ista":"Matejovicova L. 2022. Genetic basis of flower colour as a model for adaptive evolution. Institute of Science and Technology Austria.","ieee":"L. Matejovicova, “Genetic basis of flower colour as a model for adaptive evolution,” Institute of Science and Technology Austria, 2022."},"alternative_title":["ISTA Thesis"],"author":[{"id":"2DFDEC72-F248-11E8-B48F-1D18A9856A87","full_name":"Matejovicova, Lenka","first_name":"Lenka","last_name":"Matejovicova"}],"type":"dissertation","day":"06","degree_awarded":"PhD","publisher":"Institute of Science and Technology Austria","status":"public","department":[{"_id":"GradSch"},{"_id":"NiBa"}],"page":"112","date_created":"2022-04-07T08:19:54Z","supervisor":[{"id":"4880FE40-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8548-5240","last_name":"Barton","full_name":"Barton, Nicholas H","first_name":"Nicholas H"}],"month":"04","publication_identifier":{"isbn":["978-3-99078-016-9"],"issn":["2663-337X"]},"acknowledged_ssus":[{"_id":"ScienComp"},{"_id":"Bio"}],"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","date_updated":"2023-06-23T06:26:41Z","has_accepted_license":"1","year":"2022","oa_version":"Published Version","oa":1,"publication_status":"published","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"file_date_updated":"2022-04-07T08:11:51Z","article_processing_charge":"No","_id":"11128","abstract":[{"text":"Although we often see studies focusing on simple or even discrete traits in studies of colouration,\r\nthe variation of “appearance” phenotypes found in nature is often more complex, continuous\r\nand high-dimensional. Therefore, we developed automated methods suitable for large datasets\r\nof genomes and images, striving to account for their complex nature, while minimising human\r\nbias. We used these methods on a dataset of more than 20, 000 plant SNP genomes and\r\ncorresponding fower images from a hybrid zone of two subspecies of Antirrhinum majus with\r\ndistinctly coloured fowers to improve our understanding of the genetic nature of the fower\r\ncolour in our study system.\r\nFirstly, we use the advantage of large numbers of genotyped plants to estimate the haplotypes in\r\nthe main fower colour regulating region. We study colour- and geography-related characteristics\r\nof the estimated haplotypes and how they connect to their relatedness. We show discrepancies\r\nfrom the expected fower colour distributions given the genotype and identify particular\r\nhaplotypes leading to unexpected phenotypes. We also confrm a signifcant defcit of the\r\ndouble recessive recombinant and quite surprisingly, we show that haplotypes of the most\r\nfrequent parental type are much less variable than others.\r\nSecondly, we introduce our pipeline capable of processing tens of thousands of full fower\r\nimages without human interaction and summarising each image into a set of informative scores.\r\nWe show the compatibility of these machine-measured fower colour scores with the previously\r\nused manual scores and study impact of external efect on the resulting scores. Finally, we use\r\nthe machine-measured fower colour scores to ft and examine a phenotype cline across the\r\nhybrid zone in Planoles using full fower images as opposed to discrete, manual scores and\r\ncompare it with the genotypic cline.","lang":"eng"}],"date_published":"2022-04-06T00:00:00Z","file":[{"content_type":"application/pdf","relation":"main_file","file_id":"11129","date_created":"2022-04-07T08:11:34Z","file_name":"LenkaPhD_Official_PDFA.pdf","creator":"cchlebak","file_size":11906472,"date_updated":"2022-04-07T08:11:34Z","access_level":"open_access","checksum":"e9609bc4e8f8e20146fc1125fd4f1bf7"},{"file_size":23036766,"creator":"cchlebak","file_name":"LenkaPhD Official_source.zip","access_level":"closed","date_updated":"2022-04-07T08:11:51Z","checksum":"99d67040432fd07a225643a212ee8588","file_id":"11130","relation":"source_file","content_type":"application/x-zip-compressed","date_created":"2022-04-07T08:11:51Z"}]},{"main_file_link":[{"open_access":"1","url":" https://doi.org/10.48550/arXiv.2103.03906"}],"oa":1,"publication_status":"published","volume":11,"issue":"4","article_processing_charge":"No","arxiv":1,"date_published":"2022-10-01T00:00:00Z","_id":"11135","abstract":[{"lang":"eng","text":"We consider a correlated NxN Hermitian random matrix with a polynomially decaying metric correlation structure. By calculating the trace of the moments of the matrix and using the summable decay of the cumulants, we show that its operator norm is stochastically dominated by one."}],"article_number":"2250036","publication_identifier":{"eissn":["2010-3271"],"issn":["2010-3263"]},"date_updated":"2023-08-03T06:32:22Z","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","scopus_import":"1","external_id":{"isi":["000848873800001"],"arxiv":["2103.03906"]},"oa_version":"Preprint","year":"2022","article_type":"original","isi":1,"publisher":"World Scientific","intvolume":"        11","status":"public","quality_controlled":"1","department":[{"_id":"GradSch"},{"_id":"LaEr"}],"publication":"Random Matrices: Theory and Applications","date_created":"2022-04-08T07:11:12Z","month":"10","doi":"10.1142/s2010326322500368","language":[{"iso":"eng"}],"keyword":["Discrete Mathematics and Combinatorics","Statistics","Probability and Uncertainty","Statistics and Probability","Algebra and Number Theory"],"title":"On the operator norm of a Hermitian random matrix with correlated entries","citation":{"chicago":"Reker, Jana. “On the Operator Norm of a Hermitian Random Matrix with Correlated Entries.” <i>Random Matrices: Theory and Applications</i>. World Scientific, 2022. <a href=\"https://doi.org/10.1142/s2010326322500368\">https://doi.org/10.1142/s2010326322500368</a>.","ista":"Reker J. 2022. On the operator norm of a Hermitian random matrix with correlated entries. Random Matrices: Theory and Applications. 11(4), 2250036.","ieee":"J. Reker, “On the operator norm of a Hermitian random matrix with correlated entries,” <i>Random Matrices: Theory and Applications</i>, vol. 11, no. 4. World Scientific, 2022.","mla":"Reker, Jana. “On the Operator Norm of a Hermitian Random Matrix with Correlated Entries.” <i>Random Matrices: Theory and Applications</i>, vol. 11, no. 4, 2250036, World Scientific, 2022, doi:<a href=\"https://doi.org/10.1142/s2010326322500368\">10.1142/s2010326322500368</a>.","short":"J. Reker, Random Matrices: Theory and Applications 11 (2022).","ama":"Reker J. On the operator norm of a Hermitian random matrix with correlated entries. <i>Random Matrices: Theory and Applications</i>. 2022;11(4). doi:<a href=\"https://doi.org/10.1142/s2010326322500368\">10.1142/s2010326322500368</a>","apa":"Reker, J. (2022). On the operator norm of a Hermitian random matrix with correlated entries. <i>Random Matrices: Theory and Applications</i>. World Scientific. <a href=\"https://doi.org/10.1142/s2010326322500368\">https://doi.org/10.1142/s2010326322500368</a>"},"type":"journal_article","author":[{"id":"e796e4f9-dc8d-11ea-abe3-97e26a0323e9","full_name":"Reker, Jana","first_name":"Jana","last_name":"Reker"}],"day":"01"},{"publication_status":"published","volume":25,"article_processing_charge":"No","_id":"11142","abstract":[{"text":"SnTe is a promising Pb-free thermoelectric (TE) material with high electrical conductivity. We discovered the synergistic effect of Bi2O3 on enhancing the average power factor (PF) and overall ZT value of the SnTe-based thermoelectric material. The introduction of Bi2O3 forms plenty of SnO2, Bi2O3, and Bi-rich nanoprecipitates. These interfaces between the SnTe matrix and the nanoprecipitates can enhance the average PF through the energy filtering effect. On the other hand, abundant and diverse nanoprecipitates can significantly diminish the lattice thermal conductivity (κlat) through enhanced phonon scattering. The synergistic effect of Bi2O3 resulted in a maximum ZT (ZTmax) value of 0.9 at SnTe-2% Bi2O3 and an average ZT (ZTave) value of 0.4 for SnTe-4% Bi2O3 from 300 K to 823 K. The work provides an excellent reference to develop non-toxic high-performance TE materials.","lang":"eng"}],"date_published":"2022-04-01T00:00:00Z","article_number":"100985","publication_identifier":{"eissn":["2468-6069"]},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","date_updated":"2023-08-03T06:28:16Z","external_id":{"isi":["000798679100010"]},"scopus_import":"1","oa_version":"None","year":"2022","article_type":"original","isi":1,"publisher":"Elsevier","intvolume":"        25","status":"public","department":[{"_id":"MaIb"}],"quality_controlled":"1","publication":"Materials Today Energy","date_created":"2022-04-10T22:01:39Z","month":"04","acknowledgement":"This work was supported by National Natural Science Foundation of China (52002042), National Key Research and Development Program of China (2018YFA0702100 and 2018YFB0703600), 111 Project (B17002) and Lise Meitner Project M 2889-N. This work was also supported by the National Postdoctoral Program for Innovative Talents (BX20200028). L.D.Z. appreciates the support of the high-performance computing (HPC) resources at Beihang University, the National Science Fund for Distinguished Young Scholars (51925101), and center for High Pressure Science and Technology Advanced Research (HPSTAR) for SEM and TEM measurements.","project":[{"_id":"9B8804FC-BA93-11EA-9121-9846C619BF3A","name":"Bottom-up Engineering for Thermoelectric Applications","grant_number":"M02889"}],"doi":"10.1016/j.mtener.2022.100985","language":[{"iso":"eng"}],"title":"Enhanced thermoelectric performance in SnTe due to the energy filtering effect introduced by Bi2O3","citation":{"ama":"Hong T, Guo C, Wang D, et al. Enhanced thermoelectric performance in SnTe due to the energy filtering effect introduced by Bi2O3. <i>Materials Today Energy</i>. 2022;25. doi:<a href=\"https://doi.org/10.1016/j.mtener.2022.100985\">10.1016/j.mtener.2022.100985</a>","apa":"Hong, T., Guo, C., Wang, D., Qin, B., Chang, C., Gao, X., &#38; Zhao, L. D. (2022). Enhanced thermoelectric performance in SnTe due to the energy filtering effect introduced by Bi2O3. <i>Materials Today Energy</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.mtener.2022.100985\">https://doi.org/10.1016/j.mtener.2022.100985</a>","short":"T. Hong, C. Guo, D. Wang, B. Qin, C. Chang, X. Gao, L.D. Zhao, Materials Today Energy 25 (2022).","mla":"Hong, Tao, et al. “Enhanced Thermoelectric Performance in SnTe Due to the Energy Filtering Effect Introduced by Bi2O3.” <i>Materials Today Energy</i>, vol. 25, 100985, Elsevier, 2022, doi:<a href=\"https://doi.org/10.1016/j.mtener.2022.100985\">10.1016/j.mtener.2022.100985</a>.","chicago":"Hong, Tao, Changrong Guo, Dongyang Wang, Bingchao Qin, Cheng Chang, Xiang Gao, and Li Dong Zhao. “Enhanced Thermoelectric Performance in SnTe Due to the Energy Filtering Effect Introduced by Bi2O3.” <i>Materials Today Energy</i>. Elsevier, 2022. <a href=\"https://doi.org/10.1016/j.mtener.2022.100985\">https://doi.org/10.1016/j.mtener.2022.100985</a>.","ista":"Hong T, Guo C, Wang D, Qin B, Chang C, Gao X, Zhao LD. 2022. Enhanced thermoelectric performance in SnTe due to the energy filtering effect introduced by Bi2O3. Materials Today Energy. 25, 100985.","ieee":"T. Hong <i>et al.</i>, “Enhanced thermoelectric performance in SnTe due to the energy filtering effect introduced by Bi2O3,” <i>Materials Today Energy</i>, vol. 25. Elsevier, 2022."},"author":[{"last_name":"Hong","full_name":"Hong, Tao","first_name":"Tao"},{"full_name":"Guo, Changrong","first_name":"Changrong","last_name":"Guo"},{"last_name":"Wang","first_name":"Dongyang","full_name":"Wang, Dongyang"},{"last_name":"Qin","full_name":"Qin, Bingchao","first_name":"Bingchao"},{"orcid":"0000-0002-9515-4277","id":"9E331C2E-9F27-11E9-AE48-5033E6697425","first_name":"Cheng","full_name":"Chang, Cheng","last_name":"Chang"},{"first_name":"Xiang","full_name":"Gao, Xiang","last_name":"Gao"},{"last_name":"Zhao","full_name":"Zhao, Li Dong","first_name":"Li Dong"}],"type":"journal_article","day":"01"},{"article_processing_charge":"No","issue":"13","abstract":[{"text":"Dravet syndrome is a neurodevelopmental disorder characterized by epilepsy, intellectual disability, and sudden death due to pathogenic variants in SCN1A with loss of function of the sodium channel subunit Nav1.1. Nav1.1-expressing parvalbumin GABAergic interneurons (PV-INs) from young Scn1a+/− mice show impaired action potential generation. An approach assessing PV-IN function in the same mice at two time points shows impaired spike generation in all Scn1a+/− mice at postnatal days (P) 16–21, whether deceased prior or surviving to P35, with normalization by P35 in surviving mice. However, PV-IN synaptic transmission is dysfunctional in young Scn1a+/− mice that did not survive and in Scn1a+/− mice ≥ P35. Modeling confirms that PV-IN axonal propagation is more sensitive to decreased sodium conductance than spike generation. These results demonstrate dynamic dysfunction in Dravet syndrome: combined abnormalities of PV-IN spike generation and propagation drives early disease severity, while ongoing dysfunction of synaptic transmission contributes to chronic pathology.","lang":"eng"}],"_id":"11143","date_published":"2022-03-29T00:00:00Z","file":[{"content_type":"application/pdf","relation":"main_file","file_id":"11172","date_created":"2022-04-15T11:00:58Z","success":1,"file_name":"2022_CellReports_Kaneko.pdf","creator":"dernst","file_size":4774216,"checksum":"49105c6c27c9af0f37f50a8bbb4d380d","date_updated":"2022-04-15T11:00:58Z","access_level":"open_access"}],"article_number":"110580","oa":1,"publication_status":"published","tmp":{"name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","short":"CC BY-NC-ND (4.0)"},"volume":38,"file_date_updated":"2022-04-15T11:00:58Z","has_accepted_license":"1","year":"2022","oa_version":"Published Version","article_type":"original","publication_identifier":{"eissn":["2211-1247"]},"scopus_import":"1","external_id":{"isi":["000779794000001"]},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","date_updated":"2023-08-03T06:32:55Z","date_created":"2022-04-10T22:01:39Z","month":"03","isi":1,"publisher":"Elsevier","intvolume":"        38","status":"public","publication":"Cell Reports","department":[{"_id":"TiVo"}],"quality_controlled":"1","title":"Developmentally regulated impairment of parvalbumin interneuron synaptic transmission in an experimental model of Dravet syndrome","citation":{"ama":"Kaneko K, Currin C, Goff KM, et al. Developmentally regulated impairment of parvalbumin interneuron synaptic transmission in an experimental model of Dravet syndrome. <i>Cell Reports</i>. 2022;38(13). doi:<a href=\"https://doi.org/10.1016/j.celrep.2022.110580\">10.1016/j.celrep.2022.110580</a>","apa":"Kaneko, K., Currin, C., Goff, K. M., Wengert, E. R., Somarowthu, A., Vogels, T. P., &#38; Goldberg, E. M. (2022). Developmentally regulated impairment of parvalbumin interneuron synaptic transmission in an experimental model of Dravet syndrome. <i>Cell Reports</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.celrep.2022.110580\">https://doi.org/10.1016/j.celrep.2022.110580</a>","short":"K. Kaneko, C. Currin, K.M. Goff, E.R. Wengert, A. Somarowthu, T.P. Vogels, E.M. Goldberg, Cell Reports 38 (2022).","mla":"Kaneko, Keisuke, et al. “Developmentally Regulated Impairment of Parvalbumin Interneuron Synaptic Transmission in an Experimental Model of Dravet Syndrome.” <i>Cell Reports</i>, vol. 38, no. 13, 110580, Elsevier, 2022, doi:<a href=\"https://doi.org/10.1016/j.celrep.2022.110580\">10.1016/j.celrep.2022.110580</a>.","chicago":"Kaneko, Keisuke, Christopher Currin, Kevin M. Goff, Eric R. Wengert, Ala Somarowthu, Tim P Vogels, and Ethan M. Goldberg. “Developmentally Regulated Impairment of Parvalbumin Interneuron Synaptic Transmission in an Experimental Model of Dravet Syndrome.” <i>Cell Reports</i>. Elsevier, 2022. <a href=\"https://doi.org/10.1016/j.celrep.2022.110580\">https://doi.org/10.1016/j.celrep.2022.110580</a>.","ieee":"K. Kaneko <i>et al.</i>, “Developmentally regulated impairment of parvalbumin interneuron synaptic transmission in an experimental model of Dravet syndrome,” <i>Cell Reports</i>, vol. 38, no. 13. Elsevier, 2022.","ista":"Kaneko K, Currin C, Goff KM, Wengert ER, Somarowthu A, Vogels TP, Goldberg EM. 2022. Developmentally regulated impairment of parvalbumin interneuron synaptic transmission in an experimental model of Dravet syndrome. Cell Reports. 38(13), 110580."},"ec_funded":1,"author":[{"last_name":"Kaneko","first_name":"Keisuke","full_name":"Kaneko, Keisuke"},{"full_name":"Currin, Christopher","first_name":"Christopher","last_name":"Currin","orcid":"0000-0002-4809-5059","id":"e8321fc5-3091-11eb-8a53-83f309a11ac9"},{"last_name":"Goff","first_name":"Kevin M.","full_name":"Goff, Kevin M."},{"full_name":"Wengert, Eric R.","first_name":"Eric R.","last_name":"Wengert"},{"last_name":"Somarowthu","full_name":"Somarowthu, Ala","first_name":"Ala"},{"orcid":"0000-0003-3295-6181","id":"CB6FF8D2-008F-11EA-8E08-2637E6697425","full_name":"Vogels, Tim P","first_name":"Tim P","last_name":"Vogels"},{"last_name":"Goldberg","full_name":"Goldberg, Ethan M.","first_name":"Ethan M."}],"type":"journal_article","day":"29","project":[{"_id":"0aacfa84-070f-11eb-9043-d7eb2c709234","call_identifier":"H2020","name":"Learning the shape of synaptic plasticity rules for neuronal architectures and function through machine learning.","grant_number":"819603"},{"name":"NOMIS Fellowship Program","_id":"9B861AAC-BA93-11EA-9121-9846C619BF3A"}],"acknowledgement":"We would like to thank Bernardo Rudy, Joanna Mattis, and Laura Mcgarry for comments on a previous version of the manuscript; Xiaohong Zhang for expert technical support and mouse colony maintenance; Melody Cheng for assistance with generation of the graphical abstract; and Jennifer Kearney for the gift of Scn1a+/− mice. This work was supported by the National Institute of Neurological Disorders and Stroke of the National Institutes of Health under F31NS111803 (to K.M.G.) and K08NS097633 and R01NS110869 (to E.M.G.), the Dravet Syndrome Foundation (to A.S.), an ERC Consolidator Grant (SYNAPSEEK) (to T.P.V.), and the NOMIS Foundation through the NOMIS Fellowships program at IST Austria (to C.C.). The graphical abstract was prepared using BioRender software (BioRender.com).","ddc":["570"],"doi":"10.1016/j.celrep.2022.110580","language":[{"iso":"eng"}]},{"article_processing_charge":"No","issue":"6587","abstract":[{"lang":"eng","text":"Thermoelectric materials allow for direct conversion between heat and electricity, offering the potential for power generation. The average dimensionless figure of merit ZTave determines device efficiency. N-type tin selenide crystals exhibit outstanding three-dimensional charge and two-dimensional phonon transport along the out-of-plane direction, contributing to a high maximum figure of merit Zmax of ~3.6 × 10−3 per kelvin but a moderate ZTave of ~1.1. We found an attractive high Zmax of ~4.1 × 10−3 per kelvin at 748 kelvin and a ZTave of ~1.7 at 300 to 773 kelvin in chlorine-doped and lead-alloyed tin selenide crystals by phonon-electron decoupling. The chlorine-induced low deformation potential improved the carrier mobility. The lead-induced mass and strain fluctuations reduced the lattice thermal conductivity. Phonon-electron decoupling plays a critical role to achieve high-performance thermoelectrics."}],"_id":"11144","date_published":"2022-03-25T00:00:00Z","publication_status":"published","volume":375,"article_type":"original","year":"2022","oa_version":"None","external_id":{"pmid":["35324303"],"isi":["000778894800038"]},"scopus_import":"1","date_updated":"2023-10-16T09:10:36Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"eissn":["1095-9203"]},"page":"1385-1389","month":"03","date_created":"2022-04-10T22:01:40Z","publisher":"American Association for the Advancement of Science","isi":1,"publication":"Science","quality_controlled":"1","department":[{"_id":"MaIb"}],"status":"public","intvolume":"       375","citation":{"chicago":"Su, Lizhong, Dongyang Wang, Sining Wang, Bingchao Qin, Yuping Wang, Yongxin Qin, Yang Jin, Cheng Chang, and Li Dong Zhao. “High Thermoelectric Performance Realized through Manipulating Layered Phonon-Electron Decoupling.” <i>Science</i>. American Association for the Advancement of Science, 2022. <a href=\"https://doi.org/10.1126/science.abn8997\">https://doi.org/10.1126/science.abn8997</a>.","ieee":"L. Su <i>et al.</i>, “High thermoelectric performance realized through manipulating layered phonon-electron decoupling,” <i>Science</i>, vol. 375, no. 6587. American Association for the Advancement of Science, pp. 1385–1389, 2022.","ista":"Su L, Wang D, Wang S, Qin B, Wang Y, Qin Y, Jin Y, Chang C, Zhao LD. 2022. High thermoelectric performance realized through manipulating layered phonon-electron decoupling. Science. 375(6587), 1385–1389.","mla":"Su, Lizhong, et al. “High Thermoelectric Performance Realized through Manipulating Layered Phonon-Electron Decoupling.” <i>Science</i>, vol. 375, no. 6587, American Association for the Advancement of Science, 2022, pp. 1385–89, doi:<a href=\"https://doi.org/10.1126/science.abn8997\">10.1126/science.abn8997</a>.","short":"L. Su, D. Wang, S. Wang, B. Qin, Y. Wang, Y. Qin, Y. Jin, C. Chang, L.D. Zhao, Science 375 (2022) 1385–1389.","ama":"Su L, Wang D, Wang S, et al. High thermoelectric performance realized through manipulating layered phonon-electron decoupling. <i>Science</i>. 2022;375(6587):1385-1389. doi:<a href=\"https://doi.org/10.1126/science.abn8997\">10.1126/science.abn8997</a>","apa":"Su, L., Wang, D., Wang, S., Qin, B., Wang, Y., Qin, Y., … Zhao, L. D. (2022). High thermoelectric performance realized through manipulating layered phonon-electron decoupling. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.abn8997\">https://doi.org/10.1126/science.abn8997</a>"},"title":"High thermoelectric performance realized through manipulating layered phonon-electron decoupling","day":"25","type":"journal_article","author":[{"last_name":"Su","first_name":"Lizhong","full_name":"Su, Lizhong"},{"last_name":"Wang","full_name":"Wang, Dongyang","first_name":"Dongyang"},{"first_name":"Sining","full_name":"Wang, Sining","last_name":"Wang"},{"first_name":"Bingchao","full_name":"Qin, Bingchao","last_name":"Qin"},{"last_name":"Wang","first_name":"Yuping","full_name":"Wang, Yuping"},{"full_name":"Qin, Yongxin","first_name":"Yongxin","last_name":"Qin"},{"last_name":"Jin","first_name":"Yang","full_name":"Jin, Yang"},{"first_name":"Cheng","full_name":"Chang, Cheng","last_name":"Chang","id":"9E331C2E-9F27-11E9-AE48-5033E6697425","orcid":"0000-0002-9515-4277"},{"full_name":"Zhao, Li Dong","first_name":"Li Dong","last_name":"Zhao"}],"project":[{"_id":"9B8804FC-BA93-11EA-9121-9846C619BF3A","grant_number":"M02889","name":"Bottom-up Engineering for Thermoelectric Applications"}],"pmid":1,"acknowledgement":"This work was supported by the Basic Science Center Project of the National Natural Science Foundation of China (51788104), the National Key Research and Development Program of China (2018YFA0702100), the National Science Fund for Distinguished Young Scholars (51925101), the 111 Project (B17002), the Lise Meitner Project (M2889-N), and the National Key Research and Development Program of China (2018YFB0703600). This work is also supported by the National Postdoctoral Program for Innovative Talents (BX20200028). L.-D.Z. is thankful for the high-performance computing resources at Beihang University.","language":[{"iso":"eng"}],"doi":"10.1126/science.abn8997"},{"publication_identifier":{"issn":["0272-5428"],"isbn":["9781665420556"]},"scopus_import":"1","external_id":{"arxiv":["2012.10584"],"isi":["000802209600065"]},"date_updated":"2023-08-03T06:57:02Z","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","year":"2022","oa_version":"Preprint","volume":2022,"oa":1,"main_file_link":[{"open_access":"1","url":" https://doi.org/10.48550/arXiv.2012.10584"}],"publication_status":"published","_id":"11145","date_published":"2022-02-01T00:00:00Z","abstract":[{"lang":"eng","text":"List-decodability of Reed-Solomon codes has re-ceived a lot of attention, but the best-possible dependence between the parameters is still not well-understood. In this work, we focus on the case where the list-decoding radius is of the form r=1−ε for ε tending to zero. Our main result states that there exist Reed-Solomon codes with rate Ω(ε) which are (1−ε,O(1/ε) -list-decodable, meaning that any Hamming ball of radius 1−ε contains at most O(1/ε) codewords. This trade-off between rate and list-decoding radius is best-possible for any code with list size less than exponential in the block length. By achieving this trade-off between rate and list-decoding radius we improve a recent result of Guo, Li, Shangguan, Tamo, and Wootters, and resolve the main motivating question of their work. Moreover, while their result requires the field to be exponentially large in the block length, we only need the field size to be polynomially large (and in fact, almost-linear suffices). We deduce our main result from a more general theorem, in which we prove good list-decodability properties of random puncturings of any given code with very large distance."}],"article_processing_charge":"No","arxiv":1,"doi":"10.1109/FOCS52979.2021.00075","language":[{"iso":"eng"}],"related_material":{"record":[{"status":"public","id":"10775","relation":"later_version"}]},"author":[{"last_name":"Ferber","full_name":"Ferber, Asaf","first_name":"Asaf"},{"last_name":"Kwan","first_name":"Matthew Alan","full_name":"Kwan, Matthew Alan","id":"5fca0887-a1db-11eb-95d1-ca9d5e0453b3","orcid":"0000-0002-4003-7567"},{"full_name":"Sauermann, Lisa","first_name":"Lisa","last_name":"Sauermann"}],"type":"conference","day":"01","title":"List-decodability with large radius for Reed-Solomon codes","conference":{"name":"FOCS: Symposium on Foundations of Computer Science","end_date":"2022-02-10","start_date":"2022-02-07","location":"Denver, CO, United States"},"citation":{"ista":"Ferber A, Kwan MA, Sauermann L. 2022. List-decodability with large radius for Reed-Solomon codes. 62nd Annual IEEE Symposium on Foundations of Computer Science. FOCS: Symposium on Foundations of Computer Science vol. 2022, 720–726.","ieee":"A. Ferber, M. A. Kwan, and L. Sauermann, “List-decodability with large radius for Reed-Solomon codes,” in <i>62nd Annual IEEE Symposium on Foundations of Computer Science</i>, Denver, CO, United States, 2022, vol. 2022, pp. 720–726.","chicago":"Ferber, Asaf, Matthew Alan Kwan, and Lisa Sauermann. “List-Decodability with Large Radius for Reed-Solomon Codes.” In <i>62nd Annual IEEE Symposium on Foundations of Computer Science</i>, 2022:720–26. IEEE, 2022. <a href=\"https://doi.org/10.1109/FOCS52979.2021.00075\">https://doi.org/10.1109/FOCS52979.2021.00075</a>.","mla":"Ferber, Asaf, et al. “List-Decodability with Large Radius for Reed-Solomon Codes.” <i>62nd Annual IEEE Symposium on Foundations of Computer Science</i>, vol. 2022, IEEE, 2022, pp. 720–26, doi:<a href=\"https://doi.org/10.1109/FOCS52979.2021.00075\">10.1109/FOCS52979.2021.00075</a>.","short":"A. Ferber, M.A. Kwan, L. Sauermann, in:, 62nd Annual IEEE Symposium on Foundations of Computer Science, IEEE, 2022, pp. 720–726.","apa":"Ferber, A., Kwan, M. A., &#38; Sauermann, L. (2022). List-decodability with large radius for Reed-Solomon codes. In <i>62nd Annual IEEE Symposium on Foundations of Computer Science</i> (Vol. 2022, pp. 720–726). Denver, CO, United States: IEEE. <a href=\"https://doi.org/10.1109/FOCS52979.2021.00075\">https://doi.org/10.1109/FOCS52979.2021.00075</a>","ama":"Ferber A, Kwan MA, Sauermann L. List-decodability with large radius for Reed-Solomon codes. In: <i>62nd Annual IEEE Symposium on Foundations of Computer Science</i>. Vol 2022. IEEE; 2022:720-726. doi:<a href=\"https://doi.org/10.1109/FOCS52979.2021.00075\">10.1109/FOCS52979.2021.00075</a>"},"intvolume":"      2022","status":"public","publication":"62nd Annual IEEE Symposium on Foundations of Computer Science","department":[{"_id":"MaKw"}],"quality_controlled":"1","isi":1,"publisher":"IEEE","date_created":"2022-04-10T22:01:40Z","month":"02","page":"720-726"},{"ddc":["570"],"doi":"10.1016/j.jsb.2022.107852","language":[{"iso":"eng"}],"keyword":["Structural Biology"],"acknowledgement":"This work was funded by the Austrian Science Fund (FWF) grant P31445 to F.K.M.S and the National Institute of Allergy and Infectious Diseases under awards R01AI147890 to R.A.D. This research was also supported by the Scientific Service Units (SSUs) of IST Austria through resources provided by Scientific Computing (SciComp), the Life Science Facility (LSF), and the Electron Microscopy Facility (EMF). We thank Dustin Morado for providing the software SubTOM for data processing. We also thank William Wan for critical reading of the manuscript and valuable feedback.","project":[{"grant_number":"P31445","name":"Structural conservation and diversity in retroviral capsid","_id":"26736D6A-B435-11E9-9278-68D0E5697425","call_identifier":"FWF"}],"pmid":1,"author":[{"full_name":"Obr, Martin","first_name":"Martin","last_name":"Obr","id":"4741CA5A-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Hagen","first_name":"Wim J.H.","full_name":"Hagen, Wim J.H."},{"last_name":"Dick","first_name":"Robert A.","full_name":"Dick, Robert A."},{"first_name":"Lingbo","full_name":"Yu, Lingbo","last_name":"Yu"},{"first_name":"Abhay","full_name":"Kotecha, Abhay","last_name":"Kotecha"},{"orcid":"0000-0003-4790-8078","id":"48AD8942-F248-11E8-B48F-1D18A9856A87","last_name":"Schur","first_name":"Florian KM","full_name":"Schur, Florian KM"}],"type":"journal_article","day":"01","title":"Exploring high-resolution cryo-ET and subtomogram averaging capabilities of contemporary DEDs","citation":{"ama":"Obr M, Hagen WJH, Dick RA, Yu L, Kotecha A, Schur FK. Exploring high-resolution cryo-ET and subtomogram averaging capabilities of contemporary DEDs. <i>Journal of Structural Biology</i>. 2022;214(2). doi:<a href=\"https://doi.org/10.1016/j.jsb.2022.107852\">10.1016/j.jsb.2022.107852</a>","apa":"Obr, M., Hagen, W. J. H., Dick, R. A., Yu, L., Kotecha, A., &#38; Schur, F. K. (2022). Exploring high-resolution cryo-ET and subtomogram averaging capabilities of contemporary DEDs. <i>Journal of Structural Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.jsb.2022.107852\">https://doi.org/10.1016/j.jsb.2022.107852</a>","short":"M. Obr, W.J.H. Hagen, R.A. Dick, L. Yu, A. Kotecha, F.K. Schur, Journal of Structural Biology 214 (2022).","mla":"Obr, Martin, et al. “Exploring High-Resolution Cryo-ET and Subtomogram Averaging Capabilities of Contemporary DEDs.” <i>Journal of Structural Biology</i>, vol. 214, no. 2, 107852, Elsevier, 2022, doi:<a href=\"https://doi.org/10.1016/j.jsb.2022.107852\">10.1016/j.jsb.2022.107852</a>.","chicago":"Obr, Martin, Wim J.H. Hagen, Robert A. Dick, Lingbo Yu, Abhay Kotecha, and Florian KM Schur. “Exploring High-Resolution Cryo-ET and Subtomogram Averaging Capabilities of Contemporary DEDs.” <i>Journal of Structural Biology</i>. Elsevier, 2022. <a href=\"https://doi.org/10.1016/j.jsb.2022.107852\">https://doi.org/10.1016/j.jsb.2022.107852</a>.","ieee":"M. Obr, W. J. H. Hagen, R. A. Dick, L. Yu, A. Kotecha, and F. K. Schur, “Exploring high-resolution cryo-ET and subtomogram averaging capabilities of contemporary DEDs,” <i>Journal of Structural Biology</i>, vol. 214, no. 2. Elsevier, 2022.","ista":"Obr M, Hagen WJH, Dick RA, Yu L, Kotecha A, Schur FK. 2022. Exploring high-resolution cryo-ET and subtomogram averaging capabilities of contemporary DEDs. Journal of Structural Biology. 214(2), 107852."},"intvolume":"       214","status":"public","department":[{"_id":"FlSc"}],"quality_controlled":"1","publication":"Journal of Structural Biology","isi":1,"publisher":"Elsevier","date_created":"2022-04-15T07:10:26Z","month":"06","publication_identifier":{"issn":["1047-8477"]},"acknowledged_ssus":[{"_id":"LifeSc"},{"_id":"ScienComp"},{"_id":"EM-Fac"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","date_updated":"2023-08-03T06:25:23Z","external_id":{"pmid":["35351542"],"isi":["000790733600001"]},"scopus_import":"1","has_accepted_license":"1","oa_version":"Published Version","year":"2022","article_type":"original","volume":214,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"file_date_updated":"2022-08-02T11:07:58Z","oa":1,"publication_status":"published","abstract":[{"text":"The potential of energy filtering and direct electron detection for cryo-electron microscopy (cryo-EM) has been well documented. Here, we assess the performance of recently introduced hardware for cryo-electron tomography (cryo-ET) and subtomogram averaging (STA), an increasingly popular structural determination method for complex 3D specimens. We acquired cryo-ET datasets of EIAV virus-like particles (VLPs) on two contemporary cryo-EM systems equipped with different energy filters and direct electron detectors (DED), specifically a Krios G4, equipped with a cold field emission gun (CFEG), Thermo Fisher Scientific Selectris X energy filter, and a Falcon 4 DED; and a Krios G3i, with a Schottky field emission gun (XFEG), a Gatan Bioquantum energy filter, and a K3 DED. We performed constrained cross-correlation-based STA on equally sized datasets acquired on the respective systems. The resulting EIAV CA hexamer reconstructions show that both systems perform comparably in the 4–6 Å resolution range based on Fourier-Shell correlation (FSC). In addition, by employing a recently introduced multiparticle refinement approach, we obtained a reconstruction of the EIAV CA hexamer at 2.9 Å. Our results demonstrate the potential of the new generation of energy filters and DEDs for STA, and the effects of using different processing pipelines on their STA outcomes.","lang":"eng"}],"_id":"11155","date_published":"2022-06-01T00:00:00Z","article_number":"107852","file":[{"relation":"main_file","file_id":"11722","content_type":"application/pdf","date_created":"2022-08-02T11:07:58Z","success":1,"file_size":7080863,"creator":"dernst","file_name":"2022_JourStructuralBiology_Obr.pdf","checksum":"0b1eb53447aae8e95ae4c12d193b0b00","access_level":"open_access","date_updated":"2022-08-02T11:07:58Z"}],"issue":"2","article_processing_charge":"Yes (via OA deal)"},{"year":"2022","has_accepted_license":"1","oa_version":"Published Version","article_type":"original","publication_identifier":{"issn":["2211-1247"]},"acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"}],"date_updated":"2024-03-25T23:30:25Z","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","external_id":{"pmid":["35385734"],"isi":["000785983900003"]},"issue":"1","article_processing_charge":"Yes","_id":"11160","date_published":"2022-04-05T00:00:00Z","abstract":[{"text":"Mutations in the chromodomain helicase DNA-binding 8 (CHD8) gene are a frequent cause of autism spectrum disorder (ASD). While its phenotypic spectrum often encompasses macrocephaly, implicating cortical abnormalities, how CHD8 haploinsufficiency affects neurodevelopmental is unclear. Here, employing human cerebral organoids, we find that CHD8 haploinsufficiency disrupted neurodevelopmental trajectories with an accelerated and delayed generation of, respectively, inhibitory and excitatory neurons that yields, at days 60 and 120, symmetrically opposite expansions in their proportions. This imbalance is consistent with an enlargement of cerebral organoids as an in vitro correlate of patients’ macrocephaly. Through an isogenic design of patient-specific mutations and mosaic organoids, we define genotype-phenotype relationships and uncover their cell-autonomous nature. Our results define cell-type-specific CHD8-dependent molecular defects related to an abnormal program of proliferation and alternative splicing. By identifying cell-type-specific effects of CHD8 mutations, our study uncovers reproducible developmental alterations that may be employed for neurodevelopmental disease modeling.","lang":"eng"}],"article_number":"110615","file":[{"content_type":"application/pdf","file_id":"11164","relation":"main_file","date_created":"2022-04-15T09:06:25Z","success":1,"file_name":"2022_CellReports_Villa.pdf","creator":"dernst","file_size":"7808644","checksum":"b4e8d68f0268dec499af333e6fd5d8e1","date_updated":"2022-04-15T09:06:25Z","access_level":"open_access"}],"oa":1,"publication_status":"published","volume":39,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"file_date_updated":"2022-04-15T09:06:25Z","title":"CHD8 haploinsufficiency links autism to transient alterations in excitatory and inhibitory trajectories","ec_funded":1,"citation":{"mla":"Villa, Carlo Emanuele, et al. “CHD8 Haploinsufficiency Links Autism to Transient Alterations in Excitatory and Inhibitory Trajectories.” <i>Cell Reports</i>, vol. 39, no. 1, 110615, Elsevier, 2022, doi:<a href=\"https://doi.org/10.1016/j.celrep.2022.110615\">10.1016/j.celrep.2022.110615</a>.","ieee":"C. E. Villa <i>et al.</i>, “CHD8 haploinsufficiency links autism to transient alterations in excitatory and inhibitory trajectories,” <i>Cell Reports</i>, vol. 39, no. 1. Elsevier, 2022.","ista":"Villa CE, Cheroni C, Dotter C, López-Tóbon A, Oliveira B, Sacco R, Yahya AÇ, Morandell J, Gabriele M, Tavakoli M, Lyudchik J, Sommer CM, Gabitto M, Danzl JG, Testa G, Novarino G. 2022. CHD8 haploinsufficiency links autism to transient alterations in excitatory and inhibitory trajectories. Cell Reports. 39(1), 110615.","chicago":"Villa, Carlo Emanuele, Cristina Cheroni, Christoph Dotter, Alejandro López-Tóbon, Bárbara Oliveira, Roberto Sacco, Aysan Çerağ Yahya, et al. “CHD8 Haploinsufficiency Links Autism to Transient Alterations in Excitatory and Inhibitory Trajectories.” <i>Cell Reports</i>. Elsevier, 2022. <a href=\"https://doi.org/10.1016/j.celrep.2022.110615\">https://doi.org/10.1016/j.celrep.2022.110615</a>.","apa":"Villa, C. E., Cheroni, C., Dotter, C., López-Tóbon, A., Oliveira, B., Sacco, R., … Novarino, G. (2022). CHD8 haploinsufficiency links autism to transient alterations in excitatory and inhibitory trajectories. <i>Cell Reports</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.celrep.2022.110615\">https://doi.org/10.1016/j.celrep.2022.110615</a>","ama":"Villa CE, Cheroni C, Dotter C, et al. CHD8 haploinsufficiency links autism to transient alterations in excitatory and inhibitory trajectories. <i>Cell Reports</i>. 2022;39(1). doi:<a href=\"https://doi.org/10.1016/j.celrep.2022.110615\">10.1016/j.celrep.2022.110615</a>","short":"C.E. Villa, C. Cheroni, C. Dotter, A. López-Tóbon, B. Oliveira, R. Sacco, A.Ç. Yahya, J. Morandell, M. Gabriele, M. Tavakoli, J. Lyudchik, C.M. Sommer, M. Gabitto, J.G. Danzl, G. Testa, G. Novarino, Cell Reports 39 (2022)."},"author":[{"first_name":"Carlo Emanuele","full_name":"Villa, Carlo Emanuele","last_name":"Villa"},{"full_name":"Cheroni, Cristina","first_name":"Cristina","last_name":"Cheroni"},{"last_name":"Dotter","full_name":"Dotter, Christoph","first_name":"Christoph","orcid":"0000-0002-9033-9096","id":"4C66542E-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Alejandro","full_name":"López-Tóbon, Alejandro","last_name":"López-Tóbon"},{"last_name":"Oliveira","first_name":"Bárbara","full_name":"Oliveira, Bárbara","id":"3B03AA1A-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Roberto","full_name":"Sacco, Roberto","last_name":"Sacco","id":"42C9F57E-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Aysan Çerağ","full_name":"Yahya, Aysan Çerağ","last_name":"Yahya","id":"365A65F8-F248-11E8-B48F-1D18A9856A87"},{"id":"4739D480-F248-11E8-B48F-1D18A9856A87","first_name":"Jasmin","full_name":"Morandell, Jasmin","last_name":"Morandell"},{"full_name":"Gabriele, Michele","first_name":"Michele","last_name":"Gabriele"},{"first_name":"Mojtaba","full_name":"Tavakoli, Mojtaba","last_name":"Tavakoli","orcid":"0000-0002-7667-6854","id":"3A0A06F4-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Lyudchik, Julia","first_name":"Julia","last_name":"Lyudchik","id":"46E28B80-F248-11E8-B48F-1D18A9856A87"},{"id":"4DF26D8C-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-1216-9105","first_name":"Christoph M","full_name":"Sommer, Christoph M","last_name":"Sommer"},{"last_name":"Gabitto","full_name":"Gabitto, Mariano","first_name":"Mariano"},{"last_name":"Danzl","first_name":"Johann G","full_name":"Danzl, Johann G","id":"42EFD3B6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8559-3973"},{"first_name":"Giuseppe","full_name":"Testa, Giuseppe","last_name":"Testa"},{"id":"3E57A680-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-7673-7178","full_name":"Novarino, Gaia","first_name":"Gaia","last_name":"Novarino"}],"type":"journal_article","day":"05","acknowledgement":"We thank Farnaz Freeman for technical assistance. This research was supported by the Scientific Service Units (SSU) of IST Austria through resources provided by the Bioimaging Facility (BIF) and the Life Science Facility (LSF). This work supported by the European Union’s Horizon 2020 research and innovation program (ERC) grant 715508 to G.N. (REVERSEAUTISM) and grant 825759 to G.T. (ENDpoiNTs); the Fondazione Cariplo 2017-0886 to A.L.T.; E-Rare-3 JTC 2018 IMPACT to M. Gabriele; and the Austrian Science Fund FWF I 4205-B to G.N. Graphical abstract and figures were created using BioRender.com.","pmid":1,"project":[{"grant_number":"715508","name":"Probing the Reversibility of Autism Spectrum Disorders by Employing in vivo and in vitro Models","call_identifier":"H2020","_id":"25444568-B435-11E9-9278-68D0E5697425"},{"grant_number":"I04205","name":"Identification of converging Molecular Pathways Across Chromatinopathies as Targets for Therapy","_id":"2690FEAC-B435-11E9-9278-68D0E5697425","call_identifier":"FWF"}],"related_material":{"record":[{"status":"public","id":"12364","relation":"dissertation_contains"}]},"ddc":["570"],"doi":"10.1016/j.celrep.2022.110615","language":[{"iso":"eng"}],"keyword":["General Biochemistry","Genetics and Molecular Biology"],"date_created":"2022-04-15T09:03:10Z","month":"04","isi":1,"publisher":"Elsevier","intvolume":"        39","status":"public","department":[{"_id":"JoDa"},{"_id":"GaNo"}],"quality_controlled":"1","publication":"Cell Reports"},{"month":"06","date_created":"2022-04-15T09:32:35Z","publisher":"Elsevier","isi":1,"publication":"Current Opinion in Structural Biology","department":[{"_id":"LeSa"}],"quality_controlled":"1","intvolume":"        74","status":"public","citation":{"mla":"Kampjut, Domen, and Leonid A. Sazanov. “Structure of Respiratory Complex I – An Emerging Blueprint for the Mechanism.” <i>Current Opinion in Structural Biology</i>, vol. 74, 102350, Elsevier, 2022, doi:<a href=\"https://doi.org/10.1016/j.sbi.2022.102350\">10.1016/j.sbi.2022.102350</a>.","chicago":"Kampjut, Domen, and Leonid A Sazanov. “Structure of Respiratory Complex I – An Emerging Blueprint for the Mechanism.” <i>Current Opinion in Structural Biology</i>. Elsevier, 2022. <a href=\"https://doi.org/10.1016/j.sbi.2022.102350\">https://doi.org/10.1016/j.sbi.2022.102350</a>.","ieee":"D. Kampjut and L. A. Sazanov, “Structure of respiratory complex I – An emerging blueprint for the mechanism,” <i>Current Opinion in Structural Biology</i>, vol. 74. Elsevier, 2022.","ista":"Kampjut D, Sazanov LA. 2022. Structure of respiratory complex I – An emerging blueprint for the mechanism. Current Opinion in Structural Biology. 74, 102350.","ama":"Kampjut D, Sazanov LA. Structure of respiratory complex I – An emerging blueprint for the mechanism. <i>Current Opinion in Structural Biology</i>. 2022;74. doi:<a href=\"https://doi.org/10.1016/j.sbi.2022.102350\">10.1016/j.sbi.2022.102350</a>","apa":"Kampjut, D., &#38; Sazanov, L. A. (2022). Structure of respiratory complex I – An emerging blueprint for the mechanism. <i>Current Opinion in Structural Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.sbi.2022.102350\">https://doi.org/10.1016/j.sbi.2022.102350</a>","short":"D. Kampjut, L.A. Sazanov, Current Opinion in Structural Biology 74 (2022)."},"title":"Structure of respiratory complex I – An emerging blueprint for the mechanism","day":"01","author":[{"full_name":"Kampjut, Domen","first_name":"Domen","last_name":"Kampjut","id":"37233050-F248-11E8-B48F-1D18A9856A87"},{"id":"338D39FE-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0977-7989","last_name":"Sazanov","full_name":"Sazanov, Leonid A","first_name":"Leonid A"}],"type":"journal_article","pmid":1,"keyword":["Molecular Biology","Structural Biology"],"language":[{"iso":"eng"}],"ddc":["570"],"doi":"10.1016/j.sbi.2022.102350","article_processing_charge":"Yes (via OA deal)","article_number":"102350","file":[{"date_updated":"2022-08-05T05:56:03Z","access_level":"open_access","checksum":"72bdde48853643a32d42b75f54965c44","file_name":"2022_CurrentOpStructBiology_Kampjut.pdf","creator":"dernst","file_size":815607,"success":1,"date_created":"2022-08-05T05:56:03Z","content_type":"application/pdf","file_id":"11725","relation":"main_file"}],"abstract":[{"text":"Complex I is one of the major respiratory complexes, conserved from bacteria to mammals. It oxidises NADH, reduces quinone and pumps protons across the membrane, thus playing a central role in the oxidative energy metabolism. In this review we discuss our current state of understanding the structure of complex I from various species of mammals, plants, fungi, and bacteria, as well as of several complex I-related proteins. By comparing the structural evidence from these systems in different redox states and data from mutagenesis and molecular simulations, we formulate the mechanisms of electron transfer and proton pumping and explain how they are conformationally and electrostatically coupled. Finally, we discuss the structural basis of the deactivation phenomenon in mammalian complex I.","lang":"eng"}],"_id":"11167","date_published":"2022-06-01T00:00:00Z","publication_status":"published","oa":1,"file_date_updated":"2022-08-05T05:56:03Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"volume":74,"article_type":"original","year":"2022","has_accepted_license":"1","oa_version":"Published Version","external_id":{"isi":["000829029500020"],"pmid":["35316665"]},"scopus_import":"1","date_updated":"2023-08-03T06:31:06Z","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","publication_identifier":{"issn":["0959-440X"]}},{"date_published":"2022-04-08T00:00:00Z","_id":"11179","abstract":[{"text":"Large oligomeric enzymes control a myriad of cellular processes, from protein synthesis and degradation to metabolism. The 0.5 MDa large TET2 aminopeptidase, a prototypical protease important for cellular homeostasis, degrades peptides within a ca. 60 Å wide tetrahedral chamber with four lateral openings. The mechanisms of substrate trafficking and processing remain debated. Here, we integrate magic-angle spinning (MAS) NMR, mutagenesis, co-evolution analysis and molecular dynamics simulations and reveal that a loop in the catalytic chamber is a key element for enzymatic function. The loop is able to stabilize ligands in the active site and may additionally have a direct role in activating the catalytic water molecule whereby a conserved histidine plays a key role. Our data provide a strong case for the functional importance of highly dynamic - and often overlooked - parts of an enzyme, and the potential of MAS NMR to investigate their dynamics at atomic resolution.","lang":"eng"}],"article_number":"1927","file":[{"access_level":"open_access","date_updated":"2022-05-02T08:48:00Z","checksum":"db61d5534e988743d6266d3675d77b08","file_size":2637590,"creator":"dernst","file_name":"2022_NatureCommunications_Gauto.pdf","success":1,"date_created":"2022-05-02T08:48:00Z","file_id":"11348","relation":"main_file","content_type":"application/pdf"}],"article_processing_charge":"No","volume":13,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"file_date_updated":"2022-05-02T08:48:00Z","oa":1,"publication_status":"published","has_accepted_license":"1","year":"2022","oa_version":"Published Version","article_type":"original","publication_identifier":{"eissn":["2041-1723"]},"date_updated":"2023-08-03T06:54:56Z","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","scopus_import":"1","external_id":{"isi":["000781498700009"]},"date_created":"2022-04-17T22:01:45Z","month":"04","intvolume":"        13","status":"public","department":[{"_id":"PaSc"}],"quality_controlled":"1","publication":"Nature Communications","isi":1,"publisher":"Springer Nature","author":[{"first_name":"Diego F.","full_name":"Gauto, Diego F.","last_name":"Gauto"},{"last_name":"Macek","full_name":"Macek, Pavel","first_name":"Pavel"},{"last_name":"Malinverni","first_name":"Duccio","full_name":"Malinverni, Duccio"},{"last_name":"Fraga","first_name":"Hugo","full_name":"Fraga, Hugo"},{"first_name":"Matteo","full_name":"Paloni, Matteo","last_name":"Paloni"},{"last_name":"Sučec","full_name":"Sučec, Iva","first_name":"Iva"},{"full_name":"Hessel, Audrey","first_name":"Audrey","last_name":"Hessel"},{"full_name":"Bustamante, Juan Pablo","first_name":"Juan Pablo","last_name":"Bustamante"},{"first_name":"Alessandro","full_name":"Barducci, Alessandro","last_name":"Barducci"},{"first_name":"Paul","full_name":"Schanda, Paul","last_name":"Schanda","id":"7B541462-FAF6-11E9-A490-E8DFE5697425","orcid":"0000-0002-9350-7606"}],"type":"journal_article","day":"08","title":"Functional control of a 0.5 MDa TET aminopeptidase by a flexible loop revealed by MAS NMR","citation":{"chicago":"Gauto, Diego F., Pavel Macek, Duccio Malinverni, Hugo Fraga, Matteo Paloni, Iva Sučec, Audrey Hessel, Juan Pablo Bustamante, Alessandro Barducci, and Paul Schanda. “Functional Control of a 0.5 MDa TET Aminopeptidase by a Flexible Loop Revealed by MAS NMR.” <i>Nature Communications</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1038/s41467-022-29423-0\">https://doi.org/10.1038/s41467-022-29423-0</a>.","ista":"Gauto DF, Macek P, Malinverni D, Fraga H, Paloni M, Sučec I, Hessel A, Bustamante JP, Barducci A, Schanda P. 2022. Functional control of a 0.5 MDa TET aminopeptidase by a flexible loop revealed by MAS NMR. Nature Communications. 13, 1927.","ieee":"D. F. Gauto <i>et al.</i>, “Functional control of a 0.5 MDa TET aminopeptidase by a flexible loop revealed by MAS NMR,” <i>Nature Communications</i>, vol. 13. Springer Nature, 2022.","mla":"Gauto, Diego F., et al. “Functional Control of a 0.5 MDa TET Aminopeptidase by a Flexible Loop Revealed by MAS NMR.” <i>Nature Communications</i>, vol. 13, 1927, Springer Nature, 2022, doi:<a href=\"https://doi.org/10.1038/s41467-022-29423-0\">10.1038/s41467-022-29423-0</a>.","short":"D.F. Gauto, P. Macek, D. Malinverni, H. Fraga, M. Paloni, I. Sučec, A. Hessel, J.P. Bustamante, A. Barducci, P. Schanda, Nature Communications 13 (2022).","ama":"Gauto DF, Macek P, Malinverni D, et al. Functional control of a 0.5 MDa TET aminopeptidase by a flexible loop revealed by MAS NMR. <i>Nature Communications</i>. 2022;13. doi:<a href=\"https://doi.org/10.1038/s41467-022-29423-0\">10.1038/s41467-022-29423-0</a>","apa":"Gauto, D. F., Macek, P., Malinverni, D., Fraga, H., Paloni, M., Sučec, I., … Schanda, P. (2022). Functional control of a 0.5 MDa TET aminopeptidase by a flexible loop revealed by MAS NMR. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-022-29423-0\">https://doi.org/10.1038/s41467-022-29423-0</a>"},"ddc":["570"],"doi":"10.1038/s41467-022-29423-0","language":[{"iso":"eng"}],"acknowledgement":"We are grateful to Bernhard Brutscher, Alicia Vallet, and Adrien Favier for excellent NMR\r\nplatform operation and management. The plasmid coding for TET2 was kindly provided\r\nby Bruno Franzetti and Jerome Boisbouvier (IBS Grenoble). We thank Anne-Marie Villard\r\nand the RoBioMol platform for preparing the loop deletion construct. The RoBioMol\r\nplatform is part of the Grenoble Instruct-ERIC center (ISBG; UAR 3518 CNRS-CEAUGA-EMBL) within the Grenoble Partnership for Structural Biology (PSB), supported by FRISBI (ANR-10-INBS-0005-02) and GRAL (ANR-10-LABX-49-01), financed within the University Grenoble Alpes graduate school (Ecoles Universitaires de Recherche) CBHEUR-GS (ANR-17-EURE-0003). This work was supported by the European Research Council (StG-2012-311318-ProtDyn2Function to P. S.) and the French Agence Nationale de la Recherche (ANR), under grant ANR-14-ACHN-0016 (M.P. and A.B.).","related_material":{"link":[{"url":"https://doi.org/10.1038/s41467-022-31243-1","relation":"erratum"}]}},{"language":[{"iso":"eng"}],"doi":"10.1145/3503221.3508432","related_material":{"record":[{"status":"public","relation":"research_data","id":"13076"}]},"project":[{"name":"Elastic Coordination for Scalable Machine Learning","grant_number":"805223","_id":"268A44D6-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"}],"acknowledgement":"We would like to thank the anonymous reviewers for their useful comments. This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 805223 ScaleML).","day":"02","type":"conference","author":[{"last_name":"Postnikova","full_name":"Postnikova, Anastasiia","first_name":"Anastasiia"},{"last_name":"Koval","first_name":"Nikita","full_name":"Koval, Nikita","id":"2F4DB10C-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Nadiradze, Giorgi","first_name":"Giorgi","last_name":"Nadiradze","id":"3279A00C-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Alistarh","first_name":"Dan-Adrian","full_name":"Alistarh, Dan-Adrian","orcid":"0000-0003-3650-940X","id":"4A899BFC-F248-11E8-B48F-1D18A9856A87"}],"citation":{"ama":"Postnikova A, Koval N, Nadiradze G, Alistarh D-A. Multi-queues can be state-of-the-art priority schedulers. In: <i>Proceedings of the 27th ACM SIGPLAN Symposium on Principles and Practice of Parallel Programming</i>. Association for Computing Machinery; 2022:353-367. doi:<a href=\"https://doi.org/10.1145/3503221.3508432\">10.1145/3503221.3508432</a>","apa":"Postnikova, A., Koval, N., Nadiradze, G., &#38; Alistarh, D.-A. (2022). Multi-queues can be state-of-the-art priority schedulers. In <i>Proceedings of the 27th ACM SIGPLAN Symposium on Principles and Practice of Parallel Programming</i> (pp. 353–367). Seoul, Republic of Korea: Association for Computing Machinery. <a href=\"https://doi.org/10.1145/3503221.3508432\">https://doi.org/10.1145/3503221.3508432</a>","short":"A. Postnikova, N. Koval, G. Nadiradze, D.-A. Alistarh, in:, Proceedings of the 27th ACM SIGPLAN Symposium on Principles and Practice of Parallel Programming, Association for Computing Machinery, 2022, pp. 353–367.","mla":"Postnikova, Anastasiia, et al. “Multi-Queues Can Be State-of-the-Art Priority Schedulers.” <i>Proceedings of the 27th ACM SIGPLAN Symposium on Principles and Practice of Parallel Programming</i>, Association for Computing Machinery, 2022, pp. 353–67, doi:<a href=\"https://doi.org/10.1145/3503221.3508432\">10.1145/3503221.3508432</a>.","chicago":"Postnikova, Anastasiia, Nikita Koval, Giorgi Nadiradze, and Dan-Adrian Alistarh. “Multi-Queues Can Be State-of-the-Art Priority Schedulers.” In <i>Proceedings of the 27th ACM SIGPLAN Symposium on Principles and Practice of Parallel Programming</i>, 353–67. Association for Computing Machinery, 2022. <a href=\"https://doi.org/10.1145/3503221.3508432\">https://doi.org/10.1145/3503221.3508432</a>.","ieee":"A. Postnikova, N. Koval, G. Nadiradze, and D.-A. Alistarh, “Multi-queues can be state-of-the-art priority schedulers,” in <i>Proceedings of the 27th ACM SIGPLAN Symposium on Principles and Practice of Parallel Programming</i>, Seoul, Republic of Korea, 2022, pp. 353–367.","ista":"Postnikova A, Koval N, Nadiradze G, Alistarh D-A. 2022. Multi-queues can be state-of-the-art priority schedulers. Proceedings of the 27th ACM SIGPLAN Symposium on Principles and Practice of Parallel Programming. PPoPP: Sympopsium on Principles and Practice of Parallel Programming, 353–367."},"ec_funded":1,"title":"Multi-queues can be state-of-the-art priority schedulers","conference":{"location":"Seoul, Republic of Korea","end_date":"2022-04-06","start_date":"2022-04-02","name":"PPoPP: Sympopsium on Principles and Practice of Parallel Programming"},"publication":"Proceedings of the 27th ACM SIGPLAN Symposium on Principles and Practice of Parallel Programming","quality_controlled":"1","department":[{"_id":"DaAl"}],"status":"public","publisher":"Association for Computing Machinery","isi":1,"month":"04","date_created":"2022-04-17T22:01:46Z","page":"353-367","external_id":{"isi":["000883318200025"],"arxiv":["2109.00657"]},"scopus_import":"1","date_updated":"2023-08-03T06:48:35Z","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","publication_identifier":{"isbn":["9781450392044"]},"oa_version":"Preprint","year":"2022","publication_status":"published","oa":1,"main_file_link":[{"url":" https://doi.org/10.48550/arXiv.2109.00657","open_access":"1"}],"date_published":"2022-04-02T00:00:00Z","_id":"11180","abstract":[{"text":"Designing and implementing efficient parallel priority schedulers is an active research area. An intriguing proposed design is the Multi-Queue: given n threads and m ≥ n distinct priority queues, task insertions are performed uniformly at random, while, to delete, a thread picks two queues uniformly at random, and removes the observed task of higher priority. This approach scales well, and has probabilistic rank guarantees: roughly, the rank of each task removed, relative to remaining tasks in all other queues, is O (m) in expectation. Yet, the performance of this pattern is below that of well-engineered schedulers, which eschew theoretical guarantees for practical efficiency.\r\n\r\nWe investigate whether it is possible to design and implement a Multi-Queue-based task scheduler that is both highly-efficient and has analytical guarantees. We propose a new variant called the Stealing Multi-Queue (SMQ), a cache-efficient variant of the Multi-Queue, which leverages both queue affinity---each thread has a local queue, from which tasks are usually removed; but, with some probability, threads also attempt to steal higher-priority tasks from the other queues---and task batching, that is, the processing of several tasks in a single insert / remove step. These ideas are well-known for task scheduling without priorities; our theoretical contribution is showing that, despite relaxations, this design can still provide rank guarantees, which in turn implies bounds on total work performed. We provide a general SMQ implementation which can surpass state-of-the-art schedulers such as OBIM and PMOD in terms of performance on popular graph-processing benchmarks. Notably, the performance improvement comes mainly from the superior rank guarantees provided by our scheduler, confirming that analytically-reasoned approaches can still provide performance improvements for priority task scheduling.","lang":"eng"}],"arxiv":1,"article_processing_charge":"No"}]