[{"date_published":"2008-10-01T00:00:00Z","doi":"10.1145/1450058.1450070","extern":1,"date_created":"2018-12-11T12:09:21Z","type":"conference","publist_id":"193","main_file_link":[{"url":"http://pub.ist.ac.at/%7Etah/Publications/interface_theories_with_component_reuse.pdf","open_access":"0"}],"publisher":"ACM","day":"01","title":"Interface theories with component reuse","year":"2008","date_updated":"2021-01-12T07:59:30Z","citation":{"chicago":"Doyen, Laurent, Thomas A Henzinger, Barbara Jobstmann, and Tatjana Petrov. “Interface Theories with Component Reuse,” 79–88. ACM, 2008. <a href=\"https://doi.org/10.1145/1450058.1450070\">https://doi.org/10.1145/1450058.1450070</a>.","apa":"Doyen, L., Henzinger, T. A., Jobstmann, B., &#38; Petrov, T. (2008). Interface theories with component reuse (pp. 79–88). Presented at the EMSOFT: Embedded Software , ACM. <a href=\"https://doi.org/10.1145/1450058.1450070\">https://doi.org/10.1145/1450058.1450070</a>","mla":"Doyen, Laurent, et al. <i>Interface Theories with Component Reuse</i>. ACM, 2008, pp. 79–88, doi:<a href=\"https://doi.org/10.1145/1450058.1450070\">10.1145/1450058.1450070</a>.","short":"L. Doyen, T.A. Henzinger, B. Jobstmann, T. Petrov, in:, ACM, 2008, pp. 79–88.","ista":"Doyen L, Henzinger TA, Jobstmann B, Petrov T. 2008. Interface theories with component reuse. EMSOFT: Embedded Software , 79–88.","ieee":"L. Doyen, T. A. Henzinger, B. Jobstmann, and T. Petrov, “Interface theories with component reuse,” presented at the EMSOFT: Embedded Software , 2008, pp. 79–88.","ama":"Doyen L, Henzinger TA, Jobstmann B, Petrov T. Interface theories with component reuse. In: ACM; 2008:79-88. doi:<a href=\"https://doi.org/10.1145/1450058.1450070\">10.1145/1450058.1450070</a>"},"conference":{"name":"EMSOFT: Embedded Software "},"_id":"4533","status":"public","publication_status":"published","month":"10","abstract":[{"lang":"eng","text":"Interface theories have been proposed to support incremental design and independent implementability. Incremental design means that the compatibility checking of interfaces can proceed for partial system descriptions, without knowing the interfaces of all components. Independent implementability means that compatible interfaces can be refined separately, maintaining compatibility. We show that these interface theories provide no formal support for component reuse, meaning that the same component cannot be used to implement several different interfaces in a design. We add a new operation to interface theories in order to support such reuse. For example, different interfaces for the same component may refer to different aspects such as functionality, timing, and power consumption. We give both stateless and stateful examples for interface theories with component reuse. To illustrate component reuse in interface-based design, we show how the stateful theory provides a natural framework for specifying and refining PCI bus clients."}],"quality_controlled":0,"page":"79 - 88","author":[{"full_name":"Doyen, Laurent","first_name":"Laurent","last_name":"Doyen"},{"last_name":"Henzinger","id":"40876CD8-F248-11E8-B48F-1D18A9856A87","first_name":"Thomas A","full_name":"Thomas Henzinger","orcid":"0000−0002−2985−7724"},{"first_name":"Barbara","full_name":"Jobstmann, Barbara","last_name":"Jobstmann"},{"first_name":"Tatjana","full_name":"Tatjana Petrov","orcid":"0000-0002-9041-0905","last_name":"Petrov","id":"3D5811FC-F248-11E8-B48F-1D18A9856A87"}]},{"main_file_link":[{"url":"http://pub.ist.ac.at/%7Etah/Publications/reduction_of_stochastic_parity_to_stochastic_mean-payoff_games.pdf","open_access":"0"}],"publisher":"Elsevier","publication":"Information Processing Letters","day":"31","year":"2008","title":"Reduction of stochastic parity to stochastic mean-payoff games","citation":{"ista":"Chatterjee K, Henzinger TA. 2008. Reduction of stochastic parity to stochastic mean-payoff games. Information Processing Letters. 106(1), 1–7.","ama":"Chatterjee K, Henzinger TA. Reduction of stochastic parity to stochastic mean-payoff games. <i>Information Processing Letters</i>. 2008;106(1):1-7. doi:<a href=\"https://doi.org/10.1016/j.ipl.2007.08.035\">10.1016/j.ipl.2007.08.035</a>","ieee":"K. Chatterjee and T. A. Henzinger, “Reduction of stochastic parity to stochastic mean-payoff games,” <i>Information Processing Letters</i>, vol. 106, no. 1. Elsevier, pp. 1–7, 2008.","chicago":"Chatterjee, Krishnendu, and Thomas A Henzinger. “Reduction of Stochastic Parity to Stochastic Mean-Payoff Games.” <i>Information Processing Letters</i>. Elsevier, 2008. <a href=\"https://doi.org/10.1016/j.ipl.2007.08.035\">https://doi.org/10.1016/j.ipl.2007.08.035</a>.","apa":"Chatterjee, K., &#38; Henzinger, T. A. (2008). Reduction of stochastic parity to stochastic mean-payoff games. <i>Information Processing Letters</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.ipl.2007.08.035\">https://doi.org/10.1016/j.ipl.2007.08.035</a>","mla":"Chatterjee, Krishnendu, and Thomas A. Henzinger. “Reduction of Stochastic Parity to Stochastic Mean-Payoff Games.” <i>Information Processing Letters</i>, vol. 106, no. 1, Elsevier, 2008, pp. 1–7, doi:<a href=\"https://doi.org/10.1016/j.ipl.2007.08.035\">10.1016/j.ipl.2007.08.035</a>.","short":"K. Chatterjee, T.A. Henzinger, Information Processing Letters 106 (2008) 1–7."},"date_updated":"2021-01-12T07:59:30Z","date_published":"2008-03-31T00:00:00Z","doi":"10.1016/j.ipl.2007.08.035","extern":1,"date_created":"2018-12-11T12:09:21Z","type":"journal_article","volume":106,"publist_id":"188","abstract":[{"text":"A stochastic graph game is played by two players on a game graph with probabilistic transitions. We consider stochastic graph games with ω-regular winning conditions specified as parity objectives, and mean-payoff (or limit-average) objectives. These games lie in NP ∩ coNP. We present a polynomial-time Turing reduction of stochastic parity games to stochastic mean-payoff games.","lang":"eng"}],"quality_controlled":0,"page":"1 - 7","author":[{"id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","last_name":"Chatterjee","orcid":"0000-0002-4561-241X","full_name":"Krishnendu Chatterjee","first_name":"Krishnendu"},{"full_name":"Thomas Henzinger","orcid":"0000−0002−2985−7724","first_name":"Thomas A","id":"40876CD8-F248-11E8-B48F-1D18A9856A87","last_name":"Henzinger"}],"issue":"1","_id":"4534","status":"public","intvolume":"       106","publication_status":"published","month":"03"},{"abstract":[{"text":"We propose the notion of logical reliability for real-time program tasks that interact through periodically updated program variables. We describe a reliability analysis that checks if the given short-term (e.g., single-period) reliability of a program variable update in an implementation is sufficient to meet the logical reliability requirement (of the program variable) in the long run. We then present a notion of design by refinement where a task can be refined by another task that writes to program variables with less logical reliability. The resulting analysis can be combined with an incremental schedulability analysis for interacting real-time tasks proposed earlier for the Hierarchical Timing Language (HTL), a coordination language for distributed real-time systems. We implemented a logical-reliability-enhanced prototype of the compiler and runtime infrastructure for HTL.","lang":"eng"}],"quality_controlled":0,"author":[{"id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","last_name":"Chatterjee","full_name":"Krishnendu Chatterjee","orcid":"0000-0002-4561-241X","first_name":"Krishnendu"},{"last_name":"Ghosal","first_name":"Arkadeb","full_name":"Ghosal, Arkadeb"},{"first_name":"Thomas A","orcid":"0000−0002−2985−7724","full_name":"Thomas Henzinger","last_name":"Henzinger","id":"40876CD8-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Iercan, Daniel","first_name":"Daniel","last_name":"Iercan"},{"full_name":"Kirsch, Christoph M","first_name":"Christoph","last_name":"Kirsch"},{"full_name":"Pinello, Claudio","first_name":"Claudio","last_name":"Pinello"},{"last_name":"Sangiovanni Vincentelli","full_name":"Sangiovanni-Vincentelli, Alberto","first_name":"Alberto"}],"page":"909 - 914","conference":{"name":"DATE: Design, Automation and Test in Europe"},"status":"public","_id":"4546","publication_status":"published","month":"01","publisher":"IEEE","main_file_link":[{"url":"http://pub.ist.ac.at/%7Etah/Publications/logical_reliability_of_interacting_real-time_tasks.pdf","open_access":"0"}],"day":"01","title":"Logical reliability of interacting real-time tasks","year":"2008","date_updated":"2021-01-12T07:59:36Z","citation":{"ama":"Chatterjee K, Ghosal A, Henzinger TA, et al. Logical reliability of interacting real-time tasks. In: IEEE; 2008:909-914. doi:<a href=\"https://doi.org/10.1145/1403375.1403595\">10.1145/1403375.1403595</a>","ieee":"K. Chatterjee <i>et al.</i>, “Logical reliability of interacting real-time tasks,” presented at the DATE: Design, Automation and Test in Europe, 2008, pp. 909–914.","ista":"Chatterjee K, Ghosal A, Henzinger TA, Iercan D, Kirsch C, Pinello C, Sangiovanni Vincentelli A. 2008. Logical reliability of interacting real-time tasks. DATE: Design, Automation and Test in Europe, 909–914.","mla":"Chatterjee, Krishnendu, et al. <i>Logical Reliability of Interacting Real-Time Tasks</i>. IEEE, 2008, pp. 909–14, doi:<a href=\"https://doi.org/10.1145/1403375.1403595\">10.1145/1403375.1403595</a>.","short":"K. Chatterjee, A. Ghosal, T.A. Henzinger, D. Iercan, C. Kirsch, C. Pinello, A. Sangiovanni Vincentelli, in:, IEEE, 2008, pp. 909–914.","apa":"Chatterjee, K., Ghosal, A., Henzinger, T. A., Iercan, D., Kirsch, C., Pinello, C., &#38; Sangiovanni Vincentelli, A. (2008). Logical reliability of interacting real-time tasks (pp. 909–914). Presented at the DATE: Design, Automation and Test in Europe, IEEE. <a href=\"https://doi.org/10.1145/1403375.1403595\">https://doi.org/10.1145/1403375.1403595</a>","chicago":"Chatterjee, Krishnendu, Arkadeb Ghosal, Thomas A Henzinger, Daniel Iercan, Christoph Kirsch, Claudio Pinello, and Alberto Sangiovanni Vincentelli. “Logical Reliability of Interacting Real-Time Tasks,” 909–14. IEEE, 2008. <a href=\"https://doi.org/10.1145/1403375.1403595\">https://doi.org/10.1145/1403375.1403595</a>."},"date_published":"2008-01-01T00:00:00Z","extern":1,"doi":"10.1145/1403375.1403595","type":"conference","date_created":"2018-12-11T12:09:25Z","publist_id":"171"},{"publication":"International Journal of Game Theory","publisher":"Springer","main_file_link":[{"url":"http://pub.ist.ac.at/%7Etah/Publications/stochastic_limit-average_games_are_in_exptime.pdf","open_access":"0"}],"day":"01","year":"2008","title":"Stochastic limit-average games are in EXPTIME","date_updated":"2021-01-12T07:59:37Z","citation":{"ista":"Chatterjee K, Majumdar R, Henzinger TA. 2008. Stochastic limit-average games are in EXPTIME. International Journal of Game Theory. 37(2), 219–234.","ama":"Chatterjee K, Majumdar R, Henzinger TA. Stochastic limit-average games are in EXPTIME. <i>International Journal of Game Theory</i>. 2008;37(2):219-234. doi:<a href=\"https://doi.org/10.1007/s00182-007-0110-5\">10.1007/s00182-007-0110-5</a>","ieee":"K. Chatterjee, R. Majumdar, and T. A. Henzinger, “Stochastic limit-average games are in EXPTIME,” <i>International Journal of Game Theory</i>, vol. 37, no. 2. Springer, pp. 219–234, 2008.","chicago":"Chatterjee, Krishnendu, Ritankar Majumdar, and Thomas A Henzinger. “Stochastic Limit-Average Games Are in EXPTIME.” <i>International Journal of Game Theory</i>. Springer, 2008. <a href=\"https://doi.org/10.1007/s00182-007-0110-5\">https://doi.org/10.1007/s00182-007-0110-5</a>.","apa":"Chatterjee, K., Majumdar, R., &#38; Henzinger, T. A. (2008). Stochastic limit-average games are in EXPTIME. <i>International Journal of Game Theory</i>. Springer. <a href=\"https://doi.org/10.1007/s00182-007-0110-5\">https://doi.org/10.1007/s00182-007-0110-5</a>","short":"K. Chatterjee, R. Majumdar, T.A. Henzinger, International Journal of Game Theory 37 (2008) 219–234.","mla":"Chatterjee, Krishnendu, et al. “Stochastic Limit-Average Games Are in EXPTIME.” <i>International Journal of Game Theory</i>, vol. 37, no. 2, Springer, 2008, pp. 219–34, doi:<a href=\"https://doi.org/10.1007/s00182-007-0110-5\">10.1007/s00182-007-0110-5</a>."},"date_published":"2008-01-01T00:00:00Z","extern":1,"doi":"10.1007/s00182-007-0110-5","type":"journal_article","date_created":"2018-12-11T12:09:25Z","publist_id":"168","volume":37,"abstract":[{"text":"The value of a finite-state two-player zero-sum stochastic game with limit-average payoff can be approximated to within ε in time exponential in a polynomial in the size of the game times polynomial in logarithmic in 1/ε, for all ε &gt; 0.","lang":"eng"}],"quality_controlled":0,"author":[{"id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","last_name":"Chatterjee","orcid":"0000-0002-4561-241X","full_name":"Krishnendu Chatterjee","first_name":"Krishnendu"},{"last_name":"Majumdar","first_name":"Ritankar","full_name":"Majumdar, Ritankar S"},{"first_name":"Thomas A","full_name":"Thomas Henzinger","orcid":"0000−0002−2985−7724","last_name":"Henzinger","id":"40876CD8-F248-11E8-B48F-1D18A9856A87"}],"page":"219 - 234","issue":"2","status":"public","_id":"4548","publication_status":"published","month":"01","intvolume":"        37"},{"status":"public","oa_version":"None","_id":"2451","month":"01","publication_status":"published","intvolume":"         1","language":[{"iso":"cze"}],"abstract":[{"lang":"eng","text":"Signal molecules known as phytohormones play a decisive role in processing signals coming to plants from the surrounding environment. They include auxin — a simple compound with a large range of effects. Auxin is irregularly deposited in plant tissues, it accumulates in certain cellules and through activation of a signal cascade it causes changes in the development programme of these cellules. This article forms a part of the series prepared in honour of the anniversary of the important plant physiologist — Bohumil Němec."}],"quality_controlled":"1","author":[{"orcid":"0000-0002-8302-7596","full_name":"Friml, Jirí","first_name":"Jirí","id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml"}],"date_published":"2007-01-01T00:00:00Z","extern":"1","type":"journal_article","date_created":"2018-12-11T11:57:44Z","volume":1,"publist_id":"4452","publication":"Živa","publisher":"CSAV","day":"01","title":"Auxin - Universal development signal in plant life","year":"2007","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","citation":{"chicago":"Friml, Jiří. “Auxin - Universal development signal in plant life.” <i>Živa</i>. CSAV, 2007.","apa":"Friml, J. (2007). Auxin - Universal development signal in plant life. <i>Živa</i>. CSAV.","mla":"Friml, Jiří. “Auxin - Universal development signal in plant life.” <i>Živa</i>, vol. 1, CSAV, 2007.","short":"J. Friml, Živa 1 (2007).","ista":"Friml J. 2007. Auxin - Universal development signal in plant life. Živa. 1.","ieee":"J. Friml, “Auxin - Universal development signal in plant life,” <i>Živa</i>, vol. 1. CSAV, 2007.","ama":"Friml J. Auxin - Universal development signal in plant life. <i>Živa</i>. 2007;1."},"date_updated":"2021-01-12T06:57:34Z"},{"_id":"2462","status":"public","publication_status":"published","intvolume":"         5","month":"08","quality_controlled":0,"author":[{"last_name":"Michniewicz","full_name":"Michniewicz, Marta","first_name":"Marta"},{"last_name":"Brewer","first_name":"Philip","full_name":"Brewer, Philip B"},{"first_name":"Jirí","orcid":"0000-0002-8302-7596","full_name":"Jirí Friml","last_name":"Friml","id":"4159519E-F248-11E8-B48F-1D18A9856A87"}],"date_created":"2018-12-11T11:57:48Z","type":"journal_article","volume":5,"publist_id":"4441","date_published":"2007-08-21T00:00:00Z","doi":"10.1199/tab.0108","extern":1,"year":"2007","title":"Polar auxin transport and asymmetric auxin distribution","date_updated":"2021-01-12T06:57:38Z","citation":{"ama":"Michniewicz M, Brewer P, Friml J. Polar auxin transport and asymmetric auxin distribution. <i>The Arabidopsis Book</i>. 2007;5. doi:<a href=\"https://doi.org/10.1199/tab.0108\">10.1199/tab.0108</a>","ieee":"M. Michniewicz, P. Brewer, and J. Friml, “Polar auxin transport and asymmetric auxin distribution,” <i>The Arabidopsis Book</i>, vol. 5. The American Society of Plant Biologists, 2007.","ista":"Michniewicz M, Brewer P, Friml J. 2007. Polar auxin transport and asymmetric auxin distribution. The Arabidopsis Book. 5.","apa":"Michniewicz, M., Brewer, P., &#38; Friml, J. (2007). Polar auxin transport and asymmetric auxin distribution. <i>The Arabidopsis Book</i>. The American Society of Plant Biologists. <a href=\"https://doi.org/10.1199/tab.0108\">https://doi.org/10.1199/tab.0108</a>","mla":"Michniewicz, Marta, et al. “Polar Auxin Transport and Asymmetric Auxin Distribution.” <i>The Arabidopsis Book</i>, vol. 5, The American Society of Plant Biologists, 2007, doi:<a href=\"https://doi.org/10.1199/tab.0108\">10.1199/tab.0108</a>.","short":"M. Michniewicz, P. Brewer, J. Friml, The Arabidopsis Book 5 (2007).","chicago":"Michniewicz, Marta, Philip Brewer, and Jiří Friml. “Polar Auxin Transport and Asymmetric Auxin Distribution.” <i>The Arabidopsis Book</i>. The American Society of Plant Biologists, 2007. <a href=\"https://doi.org/10.1199/tab.0108\">https://doi.org/10.1199/tab.0108</a>."},"publication":"The Arabidopsis Book","publisher":"The American Society of Plant Biologists","day":"21"},{"author":[{"first_name":"Eriko","full_name":"Kuramoto, Eriko","last_name":"Kuramoto"},{"first_name":"Fumino","full_name":"Fujiyama, Fumino","last_name":"Fujiyama"},{"full_name":"Unzai, Tomo","first_name":"Tomo","last_name":"Unzai"},{"full_name":"Nakamura, Kouichi","first_name":"Kouichi","last_name":"Nakamura"},{"full_name":"Hioki, Hiroyuki","first_name":"Hiroyuki","last_name":"Hioki"},{"first_name":"Takahiro","full_name":"Furuta, Takahiro","last_name":"Furuta"},{"orcid":"0000-0001-8761-9444","full_name":"Ryuichi Shigemoto","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto"},{"full_name":"Ferraguti, Francesco","first_name":"Francesco","last_name":"Ferraguti"},{"last_name":"Kaneko","first_name":"Takeshi","full_name":"Kaneko, Takeshi"}],"page":"908 - 922","quality_controlled":0,"abstract":[{"lang":"eng","text":"Metabotropic glutamate receptor 4 (mGluR4) is localized mainly to presynaptic membranes in the brain. Rat neostriatum has been reported to contain two types of mGluR4-immunoreactive axon varicosities: small, weakly immunoreactive varicosities that were distributed randomly (type 1) and large, intensely immunoreactive ones that were often aligned linearly (type 2). In the present study, most type 1 terminals formed asymmetric synapses on dendritic spines, whereas type 2 terminals made symmetric synapses on dendritic shafts, showing immunoreactivity for GABAergic markers. After depletion of neostriatal neurons, type 2 but not type 1 varicosities were largely decreased in the damaged region. When medium-sized spiny neurons (MSNs) were labeled with Sindbis virus expressing membrane-targeted green fluorescent protein, mGluR4 immunoreactivity was observed on some varicosities of their axon collaterals in immunofluorescence and immunoelectron microscopies. Furthermore, type 2 varicosities were often positive for substance P but mostly negative for striatal interneuron markers and preproenkephalin. Thus, striatonigral/striato- entopeduncular MSNs are likely to be the largest source of type 2 mGluR4-immunopositive axon terminals in the neostriatum. Next, in the double-immunofluorescence study, almost all choline acetyltransferase (ChAT)-immunopositive and 41% of NK1 receptor-positive dendrites were heavily associated with type 2 mGluR4-immunoreactive varicosities. Neuronal nitric oxide synthase (nNOS)-positive dendrites, in contrast, seemed associated with only a few type 2 varicosities. Conversely, almost all type 2 varicosities were closely apposed to NK1 receptor-positive dendrites that were known to be derived from cholinergic and nNOS-producing interneurons. These findings indicate that the mGluR4-positive terminals of MSN axon collaterals selectively form synapses with neostriatal cholinergic interneurons."}],"month":"02","publication_status":"published","intvolume":"       500","status":"public","_id":"2495","issue":"5","citation":{"ieee":"E. Kuramoto <i>et al.</i>, “Metabotropic glutamate receptor 4-immunopositive terminals of medium-sized spiny neurons selectively form synapses with cholinergic interneurons in the rat neostriatum,” <i>Journal of Comparative Neurology</i>, vol. 500, no. 5. Wiley-Blackwell, pp. 908–922, 2007.","ama":"Kuramoto E, Fujiyama F, Unzai T, et al. Metabotropic glutamate receptor 4-immunopositive terminals of medium-sized spiny neurons selectively form synapses with cholinergic interneurons in the rat neostriatum. <i>Journal of Comparative Neurology</i>. 2007;500(5):908-922. doi:<a href=\"https://doi.org/10.1002/cne.21216\">10.1002/cne.21216</a>","ista":"Kuramoto E, Fujiyama F, Unzai T, Nakamura K, Hioki H, Furuta T, Shigemoto R, Ferraguti F, Kaneko T. 2007. Metabotropic glutamate receptor 4-immunopositive terminals of medium-sized spiny neurons selectively form synapses with cholinergic interneurons in the rat neostriatum. Journal of Comparative Neurology. 500(5), 908–922.","apa":"Kuramoto, E., Fujiyama, F., Unzai, T., Nakamura, K., Hioki, H., Furuta, T., … Kaneko, T. (2007). Metabotropic glutamate receptor 4-immunopositive terminals of medium-sized spiny neurons selectively form synapses with cholinergic interneurons in the rat neostriatum. <i>Journal of Comparative Neurology</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1002/cne.21216\">https://doi.org/10.1002/cne.21216</a>","short":"E. Kuramoto, F. Fujiyama, T. Unzai, K. Nakamura, H. Hioki, T. Furuta, R. Shigemoto, F. Ferraguti, T. Kaneko, Journal of Comparative Neurology 500 (2007) 908–922.","mla":"Kuramoto, Eriko, et al. “Metabotropic Glutamate Receptor 4-Immunopositive Terminals of Medium-Sized Spiny Neurons Selectively Form Synapses with Cholinergic Interneurons in the Rat Neostriatum.” <i>Journal of Comparative Neurology</i>, vol. 500, no. 5, Wiley-Blackwell, 2007, pp. 908–22, doi:<a href=\"https://doi.org/10.1002/cne.21216\">10.1002/cne.21216</a>.","chicago":"Kuramoto, Eriko, Fumino Fujiyama, Tomo Unzai, Kouichi Nakamura, Hiroyuki Hioki, Takahiro Furuta, Ryuichi Shigemoto, Francesco Ferraguti, and Takeshi Kaneko. “Metabotropic Glutamate Receptor 4-Immunopositive Terminals of Medium-Sized Spiny Neurons Selectively Form Synapses with Cholinergic Interneurons in the Rat Neostriatum.” <i>Journal of Comparative Neurology</i>. Wiley-Blackwell, 2007. <a href=\"https://doi.org/10.1002/cne.21216\">https://doi.org/10.1002/cne.21216</a>."},"date_updated":"2021-01-12T06:57:49Z","title":"Metabotropic glutamate receptor 4-immunopositive terminals of medium-sized spiny neurons selectively form synapses with cholinergic interneurons in the rat neostriatum","year":"2007","day":"10","publication":"Journal of Comparative Neurology","publisher":"Wiley-Blackwell","publist_id":"4406","volume":500,"type":"journal_article","date_created":"2018-12-11T11:58:00Z","extern":1,"doi":"10.1002/cne.21216","date_published":"2007-02-10T00:00:00Z"},{"issue":"1","month":"04","publication_status":"published","intvolume":"       328","_id":"2496","status":"public","abstract":[{"lang":"eng","text":"Glutamate is one candidate for the neurotransmitters and/or neuromodulators involved in taste signaling in taste buds. Group II metabotropic glutamate receptors (mGluRs: mGluR2 and mGluR3) are known to function as presynaptic receptors that regulate the release of glutamate and/or other neurotransmitters in the central nervous system. Group II mGluRs are negatively linked to adenylyl cyclase through Gαi subunits and thereby reduce the turnover of cAMP. In rat taste tissues, a subset of adenylyl-cyclase-8-expressing taste cells coexpress the Gαi subunits gustducin and Gαi2. However, the expression patterns of group II mGluRs in rat taste tissues have not yet been elucidated. We have therefore examined the expression patterns of mGluR2, mGluR3, and gustducin in rat gustatory tissues. Reverse transcription/polymerase chain reaction assays have revealed that mGluR2 and mGluR3 mRNAs are expressed in the circumvallate papillae. In situ hybridization analyses have detected positive signals for mGluR2 and mGluR3 mRNAs only in the circumvallate taste buds. Among the fungiform, foliate, and circumvallate papillae, an antibody against mGluR2/3 labels a subset of taste bud cells and nerve fibers immediately beneath the taste lingual epithelium. Double-labeling experiments have demonstrated that mGluR2/3-positive cells coexpress gustducin. These results indicate that mGluR2 and mGluR3 are coupled to Gαi subunits and play roles in glutamate-mediated signaling in taste transductions."}],"page":"57 - 63","author":[{"full_name":"Toyono, Takashi","first_name":"Takashi","last_name":"Toyono"},{"full_name":"Kataoka, Shinji","first_name":"Shinji","last_name":"Kataoka"},{"full_name":"Seta, Yuji","first_name":"Yuji","last_name":"Seta"},{"first_name":"Ryuichi","orcid":"0000-0001-8761-9444","full_name":"Ryuichi Shigemoto","last_name":"Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Toyoshima","full_name":"Toyoshima, Kuniaki","first_name":"Kuniaki"}],"quality_controlled":0,"doi":"10.1007/s00441-006-0351-9","extern":1,"date_published":"2007-04-01T00:00:00Z","publist_id":"4405","volume":328,"date_created":"2018-12-11T11:58:00Z","type":"journal_article","day":"01","publication":"Cell and Tissue Research","publisher":"Springer","citation":{"ama":"Toyono T, Kataoka S, Seta Y, Shigemoto R, Toyoshima K. Expression of group II metabotropic glutamate receptors in rat gustatory papillae. <i>Cell and Tissue Research</i>. 2007;328(1):57-63. doi:<a href=\"https://doi.org/10.1007/s00441-006-0351-9\">10.1007/s00441-006-0351-9</a>","ieee":"T. Toyono, S. Kataoka, Y. Seta, R. Shigemoto, and K. Toyoshima, “Expression of group II metabotropic glutamate receptors in rat gustatory papillae,” <i>Cell and Tissue Research</i>, vol. 328, no. 1. Springer, pp. 57–63, 2007.","ista":"Toyono T, Kataoka S, Seta Y, Shigemoto R, Toyoshima K. 2007. Expression of group II metabotropic glutamate receptors in rat gustatory papillae. Cell and Tissue Research. 328(1), 57–63.","short":"T. Toyono, S. Kataoka, Y. Seta, R. Shigemoto, K. Toyoshima, Cell and Tissue Research 328 (2007) 57–63.","mla":"Toyono, Takashi, et al. “Expression of Group II Metabotropic Glutamate Receptors in Rat Gustatory Papillae.” <i>Cell and Tissue Research</i>, vol. 328, no. 1, Springer, 2007, pp. 57–63, doi:<a href=\"https://doi.org/10.1007/s00441-006-0351-9\">10.1007/s00441-006-0351-9</a>.","apa":"Toyono, T., Kataoka, S., Seta, Y., Shigemoto, R., &#38; Toyoshima, K. (2007). Expression of group II metabotropic glutamate receptors in rat gustatory papillae. <i>Cell and Tissue Research</i>. Springer. <a href=\"https://doi.org/10.1007/s00441-006-0351-9\">https://doi.org/10.1007/s00441-006-0351-9</a>","chicago":"Toyono, Takashi, Shinji Kataoka, Yuji Seta, Ryuichi Shigemoto, and Kuniaki Toyoshima. “Expression of Group II Metabotropic Glutamate Receptors in Rat Gustatory Papillae.” <i>Cell and Tissue Research</i>. Springer, 2007. <a href=\"https://doi.org/10.1007/s00441-006-0351-9\">https://doi.org/10.1007/s00441-006-0351-9</a>."},"date_updated":"2021-01-12T06:57:50Z","title":"Expression of group II metabotropic glutamate receptors in rat gustatory papillae","year":"2007"},{"quality_controlled":0,"author":[{"last_name":"Tóth","full_name":"Tóth, Kinga","first_name":"Kinga"},{"last_name":"Wittner","full_name":"Wittner, Lucia","first_name":"Lucia"},{"first_name":"Z","full_name":"Urbán, Z","last_name":"Urbán"},{"last_name":"Doyle","first_name":"Werner","full_name":"Doyle, Werner K"},{"first_name":"György","full_name":"Buzsáki, György","last_name":"Buzsáki"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","full_name":"Ryuichi Shigemoto","orcid":"0000-0001-8761-9444","first_name":"Ryuichi"},{"last_name":"Freund","full_name":"Freund, Tamás F","first_name":"Tamás"},{"first_name":"Zsófia","full_name":"Maglóczky, Zsófia","last_name":"Maglóczky"}],"page":"495 - 508","abstract":[{"text":"Substance P (SP) is known to be a peptide that facilitates epileptic activity of principal cells in the hippocampus. Paradoxically, in other models, it was found to be protective against seizures by activating substance P receptor (SPR)-expressing interneurons. Thus, these cells appear to play an important role in the generation and regulation of epileptic seizures. The number, distribution, morphological features and input characteristics of SPR-immunoreactive cells were analyzed in surgically removed hippocampi of 28 temporal lobe epileptic patients and eight control hippocampi in order to examine their changes in epileptic tissues. SPR is expressed in a subset of inhibitory cells in the control human hippocampus, they are multipolar interneurons with smooth dendrites, present in all hippocampal subfields. This cell population is considerably different from SPR-positive cells of the rat hippocampus. The CA1 (cornu Ammonis subfield 1) region was chosen for the detailed morphological analysis of the SPR-immunoreactive cells because of its extreme vulnerability in epilepsy. The presence of various neurochemical markers identifies functionally distinct interneuron types, such as those responsible for perisomatic, dendritic or interneuron-selective inhibition. We found considerable colocalization of SPR with calbindin but not with parvalbumin, calretinin, cholecystokinin and somatostatin, therefore we suppose that SPR-positive cells participate mainly in dendritic inhibition. In the non-sclerotic CA1 region they are mainly preserved, whereas their number is decreased in the sclerotic cases. In the epileptic samples their morphology is considerably altered, they possessed more dendritic branches, which often became beaded. Analyses of synaptic coverage revealed that the ratio of symmetric synaptic input of SPR-immunoreactive cells has increased in epileptic samples. Our results suggest that SPR-positive cells are preserved while principal cells are present in the CA1 region, but show reactive changes in epilepsy including intense branching and growth of their dendritic arborization.","lang":"eng"}],"status":"public","_id":"2665","publication_status":"published","month":"01","intvolume":"       144","issue":"2","year":"2007","title":"Morphology and synaptic input of substance P receptor-immunoreactive interneurons in control and epileptic human hippocampus","citation":{"ama":"Tóth K, Wittner L, Urbán Z, et al. Morphology and synaptic input of substance P receptor-immunoreactive interneurons in control and epileptic human hippocampus. <i>Neuroscience</i>. 2007;144(2):495-508. doi:<a href=\"https://doi.org/10.1016/j.neuroscience.2006.09.039\">10.1016/j.neuroscience.2006.09.039</a>","ieee":"K. Tóth <i>et al.</i>, “Morphology and synaptic input of substance P receptor-immunoreactive interneurons in control and epileptic human hippocampus,” <i>Neuroscience</i>, vol. 144, no. 2. Elsevier, pp. 495–508, 2007.","ista":"Tóth K, Wittner L, Urbán Z, Doyle W, Buzsáki G, Shigemoto R, Freund T, Maglóczky Z. 2007. Morphology and synaptic input of substance P receptor-immunoreactive interneurons in control and epileptic human hippocampus. Neuroscience. 144(2), 495–508.","apa":"Tóth, K., Wittner, L., Urbán, Z., Doyle, W., Buzsáki, G., Shigemoto, R., … Maglóczky, Z. (2007). Morphology and synaptic input of substance P receptor-immunoreactive interneurons in control and epileptic human hippocampus. <i>Neuroscience</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.neuroscience.2006.09.039\">https://doi.org/10.1016/j.neuroscience.2006.09.039</a>","short":"K. Tóth, L. Wittner, Z. Urbán, W. Doyle, G. Buzsáki, R. Shigemoto, T. Freund, Z. Maglóczky, Neuroscience 144 (2007) 495–508.","mla":"Tóth, Kinga, et al. “Morphology and Synaptic Input of Substance P Receptor-Immunoreactive Interneurons in Control and Epileptic Human Hippocampus.” <i>Neuroscience</i>, vol. 144, no. 2, Elsevier, 2007, pp. 495–508, doi:<a href=\"https://doi.org/10.1016/j.neuroscience.2006.09.039\">10.1016/j.neuroscience.2006.09.039</a>.","chicago":"Tóth, Kinga, Lucia Wittner, Z Urbán, Werner Doyle, György Buzsáki, Ryuichi Shigemoto, Tamás Freund, and Zsófia Maglóczky. “Morphology and Synaptic Input of Substance P Receptor-Immunoreactive Interneurons in Control and Epileptic Human Hippocampus.” <i>Neuroscience</i>. Elsevier, 2007. <a href=\"https://doi.org/10.1016/j.neuroscience.2006.09.039\">https://doi.org/10.1016/j.neuroscience.2006.09.039</a>."},"date_updated":"2021-01-12T06:58:55Z","publisher":"Elsevier","publication":"Neuroscience","day":"19","type":"journal_article","date_created":"2018-12-11T11:58:57Z","volume":144,"publist_id":"4232","date_published":"2007-01-19T00:00:00Z","extern":1,"doi":"10.1016/j.neuroscience.2006.09.039"},{"day":"01","publisher":"Wiley-Blackwell","publication":"Journal of Neurochemistry","date_updated":"2021-01-12T06:58:55Z","citation":{"ista":"Luyt K, Slade T, Dorward J, Durant C, Wu Y, Shigemoto R, Mundell S, Váradi A, Molnár E. 2007. Developing oligodendrocytes express functional GABAB receptors that stimulate cell proliferation and migration. Journal of Neurochemistry. 100(3), 822–840.","ieee":"K. Luyt <i>et al.</i>, “Developing oligodendrocytes express functional GABAB receptors that stimulate cell proliferation and migration,” <i>Journal of Neurochemistry</i>, vol. 100, no. 3. Wiley-Blackwell, pp. 822–840, 2007.","ama":"Luyt K, Slade T, Dorward J, et al. Developing oligodendrocytes express functional GABAB receptors that stimulate cell proliferation and migration. <i>Journal of Neurochemistry</i>. 2007;100(3):822-840. doi:<a href=\"https://doi.org/10.1111/j.1471-4159.2006.04255.x\">10.1111/j.1471-4159.2006.04255.x</a>","chicago":"Luyt, Karen, Timothy Slade, Jienchi Dorward, Claire Durant, Yue Wu, Ryuichi Shigemoto, Stuart Mundell, Anikó Váradi, and Elek Molnár. “Developing Oligodendrocytes Express Functional GABAB Receptors That Stimulate Cell Proliferation and Migration.” <i>Journal of Neurochemistry</i>. Wiley-Blackwell, 2007. <a href=\"https://doi.org/10.1111/j.1471-4159.2006.04255.x\">https://doi.org/10.1111/j.1471-4159.2006.04255.x</a>.","mla":"Luyt, Karen, et al. “Developing Oligodendrocytes Express Functional GABAB Receptors That Stimulate Cell Proliferation and Migration.” <i>Journal of Neurochemistry</i>, vol. 100, no. 3, Wiley-Blackwell, 2007, pp. 822–40, doi:<a href=\"https://doi.org/10.1111/j.1471-4159.2006.04255.x\">10.1111/j.1471-4159.2006.04255.x</a>.","short":"K. Luyt, T. Slade, J. Dorward, C. Durant, Y. Wu, R. Shigemoto, S. Mundell, A. Váradi, E. Molnár, Journal of Neurochemistry 100 (2007) 822–840.","apa":"Luyt, K., Slade, T., Dorward, J., Durant, C., Wu, Y., Shigemoto, R., … Molnár, E. (2007). Developing oligodendrocytes express functional GABAB receptors that stimulate cell proliferation and migration. <i>Journal of Neurochemistry</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1111/j.1471-4159.2006.04255.x\">https://doi.org/10.1111/j.1471-4159.2006.04255.x</a>"},"year":"2007","title":"Developing oligodendrocytes express functional GABAB receptors that stimulate cell proliferation and migration","doi":"10.1111/j.1471-4159.2006.04255.x","extern":1,"date_published":"2007-02-01T00:00:00Z","volume":100,"publist_id":"4231","date_created":"2018-12-11T11:58:57Z","type":"journal_article","abstract":[{"text":"GABAB receptors (GABABRs) are involved in early events during neuronal development. The presence of GABABRs in developing oligodendrocytes has not been established. Using immunofluorescent co-localization, we have identified GABABR proteins in O4 marker-positive oligodendrocyte precursor cells (OPCs) in 4-day-old mouse brain periventricular white matter. In culture, OPCs, differentiated oligodendrocytes (DOs) and type 2 astrocytes (ASTs) express both the GABAB1abcdf and GABAB2 subunits of the GABABR. Using semiquantitative PCR analysis with GABABR isoform-selective primers we found that the expression level of GABAB1abd was substantially higher in OPCs or ASTs than in DOs. In contrast, the GABAB2 isoform showed a similar level of expression in OPCs and DOs, and a significantly higher level in ASTs. This indicates that the expression of GABAB1 and GABAB2 subunits are under independent control during oligodendroglial development. Activation of GABABRs using the selective agonist baclofen demonstrated that these receptors are functionally active and negatively coupled to adenylyl cyclase. Manipulation of GABABR activity had no effect on OPC migration in a conventional agarose drop assay, whereas baclofen significantly increased OPC migration in a more sensitive transwell microchamber-based assay. Exposure of cultured OPCs to baclofen increased their proliferation, providing evidence for a functional role of GABABRs in oligodendrocyte development. The presence of GABABRs in developing oligodendrocytes provides a new mechanism for neuronal-glial interactions during development and may offer a novel target for promoting remyelination following white matter injury.","lang":"eng"}],"page":"822 - 840","author":[{"last_name":"Luyt","full_name":"Luyt, Karen","first_name":"Karen"},{"last_name":"Slade","first_name":"Timothy","full_name":"Slade, Timothy P"},{"last_name":"Dorward","first_name":"Jienchi","full_name":"Dorward, Jienchi J"},{"full_name":"Durant, Claire F","first_name":"Claire","last_name":"Durant"},{"full_name":"Wu, Yue","first_name":"Yue","last_name":"Wu"},{"last_name":"Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","orcid":"0000-0001-8761-9444","full_name":"Ryuichi Shigemoto"},{"last_name":"Mundell","full_name":"Mundell, Stuart J","first_name":"Stuart"},{"full_name":"Váradi, Anikó","first_name":"Anikó","last_name":"Váradi"},{"last_name":"Molnár","first_name":"Elek","full_name":"Molnár, Elek"}],"quality_controlled":0,"issue":"3","month":"02","publication_status":"published","intvolume":"       100","_id":"2666","status":"public"},{"intvolume":"        27","month":"02","publication_status":"published","_id":"2667","status":"public","issue":"8","page":"2135 - 2144","author":[{"first_name":"Miwako","full_name":"Masugi-Tokita, Miwako","last_name":"Masugi Tokita"},{"first_name":"Etsuko","full_name":"Tarusawa, Etsuko","last_name":"Tarusawa"},{"last_name":"Watanabe","full_name":"Watanabe, Masahiko","first_name":"Masahiko"},{"last_name":"Molnár","full_name":"Molnár, Elek","first_name":"Elek"},{"first_name":"Kazushi","full_name":"Fujimoto, Kazushi","last_name":"Fujimoto"},{"first_name":"Ryuichi","full_name":"Ryuichi Shigemoto","orcid":"0000-0001-8761-9444","last_name":"Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"}],"quality_controlled":0,"abstract":[{"text":"The number of AMPA receptor (AMPAR) is the major determinant of synaptic strength at glutamatergic synapses, but little is known about the absolute number and density of AMPARs in individual synapses. Using SDS-digested freeze-fracture replica labeling, which has high detection efficiency comparable with electrophysiological noise analysis for functional AMPAR, we analyzed three kinds of excitatory synapses in the molecular layer of the adult rat cerebellum. In parallel fiber (PF)-Purkinje cell (PC) synapses, we found large variability in the number (38.1 ± 34.4 particles per synapse, mean ± SD; range, 2-178 particles per synapse) and density (437 ± 277 particles/μm2; range, 48-1210 particles/μm2) of immunogold-labeled AMPARs. Two-dimensional view and high sensitivity of this method revealed irregular-shaped small AMPAR clusters within synapses. Climbing fiber (CF)-PC synapses had higher number of AMPAR labeling (68.6 ± 34.5 particles per synapse) than PF-PC and PF-interneuron synapses (36.8 ± 14.4 particles per synapse). Furthermore, AMPAR density at CF-PC and PF-interneuron synapses was approximately five times higher and more uniform than that at PF-PC synapses. These results suggest input- and target-dependent regulation of AMPAR-mediated synaptic strength.","lang":"eng"}],"publist_id":"4230","volume":27,"date_created":"2018-12-11T11:58:58Z","type":"journal_article","doi":"10.1523/JNEUROSCI.2861-06.2007","extern":1,"date_published":"2007-02-21T00:00:00Z","citation":{"chicago":"Masugi Tokita, Miwako, Etsuko Tarusawa, Masahiko Watanabe, Elek Molnár, Kazushi Fujimoto, and Ryuichi Shigemoto. “Number and Density of AMPA Receptors in Individual Synapses in the Rat Cerebellum as Revealed by SDS-Digested Freeze-Fracture Replica Labeling.” <i>Journal of Neuroscience</i>. Society for Neuroscience, 2007. <a href=\"https://doi.org/10.1523/JNEUROSCI.2861-06.2007\">https://doi.org/10.1523/JNEUROSCI.2861-06.2007</a>.","short":"M. Masugi Tokita, E. Tarusawa, M. Watanabe, E. Molnár, K. Fujimoto, R. Shigemoto, Journal of Neuroscience 27 (2007) 2135–2144.","mla":"Masugi Tokita, Miwako, et al. “Number and Density of AMPA Receptors in Individual Synapses in the Rat Cerebellum as Revealed by SDS-Digested Freeze-Fracture Replica Labeling.” <i>Journal of Neuroscience</i>, vol. 27, no. 8, Society for Neuroscience, 2007, pp. 2135–44, doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.2861-06.2007\">10.1523/JNEUROSCI.2861-06.2007</a>.","apa":"Masugi Tokita, M., Tarusawa, E., Watanabe, M., Molnár, E., Fujimoto, K., &#38; Shigemoto, R. (2007). Number and density of AMPA receptors in individual synapses in the rat cerebellum as revealed by SDS-digested freeze-fracture replica labeling. <i>Journal of Neuroscience</i>. Society for Neuroscience. <a href=\"https://doi.org/10.1523/JNEUROSCI.2861-06.2007\">https://doi.org/10.1523/JNEUROSCI.2861-06.2007</a>","ista":"Masugi Tokita M, Tarusawa E, Watanabe M, Molnár E, Fujimoto K, Shigemoto R. 2007. Number and density of AMPA receptors in individual synapses in the rat cerebellum as revealed by SDS-digested freeze-fracture replica labeling. Journal of Neuroscience. 27(8), 2135–2144.","ama":"Masugi Tokita M, Tarusawa E, Watanabe M, Molnár E, Fujimoto K, Shigemoto R. Number and density of AMPA receptors in individual synapses in the rat cerebellum as revealed by SDS-digested freeze-fracture replica labeling. <i>Journal of Neuroscience</i>. 2007;27(8):2135-2144. doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.2861-06.2007\">10.1523/JNEUROSCI.2861-06.2007</a>","ieee":"M. Masugi Tokita, E. Tarusawa, M. Watanabe, E. Molnár, K. Fujimoto, and R. Shigemoto, “Number and density of AMPA receptors in individual synapses in the rat cerebellum as revealed by SDS-digested freeze-fracture replica labeling,” <i>Journal of Neuroscience</i>, vol. 27, no. 8. Society for Neuroscience, pp. 2135–2144, 2007."},"date_updated":"2021-01-12T06:58:55Z","year":"2007","title":"Number and density of AMPA receptors in individual synapses in the rat cerebellum as revealed by SDS-digested freeze-fracture replica labeling","day":"21","publication":"Journal of Neuroscience","publisher":"Society for Neuroscience"},{"date_updated":"2021-01-12T06:58:56Z","citation":{"ama":"Boyes J, Bolam J, Shigemoto R, Stanford I. Functional presynaptic HCN channels in the rat globus pallidus. <i>European Journal of Neuroscience</i>. 2007;25(7):2081-2092. doi:<a href=\"https://doi.org/10.1111/j.1460-9568.2007.05463.x\">10.1111/j.1460-9568.2007.05463.x</a>","ieee":"J. Boyes, J. Bolam, R. Shigemoto, and I. Stanford, “Functional presynaptic HCN channels in the rat globus pallidus,” <i>European Journal of Neuroscience</i>, vol. 25, no. 7. Wiley-Blackwell, pp. 2081–2092, 2007.","ista":"Boyes J, Bolam J, Shigemoto R, Stanford I. 2007. Functional presynaptic HCN channels in the rat globus pallidus. European Journal of Neuroscience. 25(7), 2081–2092.","mla":"Boyes, Justin, et al. “Functional Presynaptic HCN Channels in the Rat Globus Pallidus.” <i>European Journal of Neuroscience</i>, vol. 25, no. 7, Wiley-Blackwell, 2007, pp. 2081–92, doi:<a href=\"https://doi.org/10.1111/j.1460-9568.2007.05463.x\">10.1111/j.1460-9568.2007.05463.x</a>.","short":"J. Boyes, J. Bolam, R. Shigemoto, I. Stanford, European Journal of Neuroscience 25 (2007) 2081–2092.","apa":"Boyes, J., Bolam, J., Shigemoto, R., &#38; Stanford, I. (2007). Functional presynaptic HCN channels in the rat globus pallidus. <i>European Journal of Neuroscience</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1111/j.1460-9568.2007.05463.x\">https://doi.org/10.1111/j.1460-9568.2007.05463.x</a>","chicago":"Boyes, Justin, John Bolam, Ryuichi Shigemoto, and Ian Stanford. “Functional Presynaptic HCN Channels in the Rat Globus Pallidus.” <i>European Journal of Neuroscience</i>. Wiley-Blackwell, 2007. <a href=\"https://doi.org/10.1111/j.1460-9568.2007.05463.x\">https://doi.org/10.1111/j.1460-9568.2007.05463.x</a>."},"year":"2007","title":"Functional presynaptic HCN channels in the rat globus pallidus","day":"01","publisher":"Wiley-Blackwell","publication":"European Journal of Neuroscience","publist_id":"4228","volume":25,"date_created":"2018-12-11T11:58:58Z","type":"journal_article","doi":"10.1111/j.1460-9568.2007.05463.x","extern":1,"date_published":"2007-04-01T00:00:00Z","page":"2081 - 2092","author":[{"full_name":"Boyes, Justin","first_name":"Justin","last_name":"Boyes"},{"last_name":"Bolam","full_name":"Bolam, John P","first_name":"John"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","full_name":"Ryuichi Shigemoto","orcid":"0000-0001-8761-9444","first_name":"Ryuichi"},{"first_name":"Ian","full_name":"Stanford, Ian M","last_name":"Stanford"}],"quality_controlled":0,"abstract":[{"text":"Hyperpolarization-activated, cyclic nucleotide-gated cation (HCN) channels are expressed postsynaptically in the rodent globus pallidus (GP), where they play several important roles in controlling GP neuronal activity. To further elucidate the role of HCN channels in the GP, immunocytochemical and electrophysiological approaches were used to test the hypothesis that HCN channels are also expressed presynaptically on the local axon collaterals of GP neurons. At the electron microscopic level, immunoperoxidase labelling for HCN1 and HCN2 was localized in GP somata and dendritic processes, myelinated and unmyelinated axons, and axon terminals. One population of labelled terminals formed symmetric synapses with somata and proximal dendrites and were immunoreactive for parvalbumin, consistent with the axon collaterals of GABAergic GP projection neurons. In addition, labelling for HCN2 and, to a lesser degree, HCN1 was observed in axon terminals that formed asymmetric synapses and were immunoreactive for the vesicular glutamate transporter 2. Immunogold labelling demonstrated that HCN1 and HCN2 were located predominantly at extrasynaptic sites along the plasma membrane of both types of terminal. To determine the function of presynaptic HCN channels in the GP, we performed whole-cell recordings from GP neurons in vitro. Bath application of the HCN channel blocker ZD7288 resulted in an increase in the frequency of mIPSCs but had no effect on their amplitude, implying that HCN channels tonically regulate the release of GABA. Their presence, and predicted role in modulating transmitter release, represents a hitherto unidentified mechanism whereby HCN channels influence the activity of GP neurons.","lang":"eng"}],"month":"04","intvolume":"        25","publication_status":"published","_id":"2668","status":"public","issue":"7"},{"abstract":[{"lang":"eng","text":"The properties of the hyperpolarization-activated current (Ih) and its roles in hippocampal network function evolve radically during development. Because Ih is conducted by the hyperpolarization- activated cyclic nucleotide-gated (HCN) cation channels, we tested the hypothesis that understanding the quantitative developmental profiles of HCN1, HCN2, and HCN4 expression, and the isoform- and age-specific progression of their subcellular distribution, should shed light on the established modifications of the properties of Ih throughout development. Combined quantitative in situ hybridization, regional western blots, and high-resolution, dual-label immunocytochemistry revealed striking and novel information about the expression and distribution of the HCN channel isoforms in the developing hippocampal formation. In cornus ammon 1 (CA) pyramidal cell layer, a robust increase of HCN1 mRNA and protein expression occurred with age, with reciprocal reduction of HCN4 and relatively stable HCN2 levels. These distinct expression patterns raised the contribution of HCN1 to the total HCN channel pool from 33% to 65% consonant with acceleration and reduced cyclic adenosine mono phosphate (cAMP) sensitivity of Ih in this region with age. In CA3, strong expression of HCN1 already neonatally supports the recently established role of this conductance in neonatal, age-specific, hippocampal oscillations (giant depolarizing potentials). Notably, HCN1 channels were present and probably transported to dendritic compartments already on postnatal day (P) 2, whereas HCN2 channel protein was not evident in dendrites for the first 2 weeks of life. HCN2 mRNA and protein expression remained fairly constant subsequent to the first week of life in all hippocampal subfields examined, whereas HCN4 mRNA and protein expression declined after maximal neonatal expression, so that the contribution of this isoform to the total HCN channel pool dropped from 43% (CA1) and 34% (CA3) on P11 to 8% (CA1) and 19% (CA3) on P90. Interneuronal expression of all HCN channel isoforms in stratum pyramidale was robust in parvalbumin-but not in cholecystokinin-expressing populations and with a subunit-specific subcellular distribution. Taken together, these data suggest that early in life, HCN4 may contribute significantly to the functions of Ih in specific hippocampal regions. In addition, these evolving, differential quantitative, and subcellular expression patterns of the HCN channel isoforms support age-specific properties and functions of Ih within the developing hippocampal formation."}],"quality_controlled":0,"page":"702 - 712","author":[{"first_name":"Amy","full_name":"Brewster, Amy L","last_name":"Brewster"},{"last_name":"Chen","full_name":"Chen, Yuncai","first_name":"Yuncai"},{"last_name":"Bender","first_name":"Roland","full_name":"Bender, Roland A"},{"last_name":"Yeh","full_name":"Yeh, Amy","first_name":"Amy"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","orcid":"0000-0001-8761-9444","full_name":"Ryuichi Shigemoto","first_name":"Ryuichi"},{"full_name":"Baram, Tallie Z","first_name":"Tallie","last_name":"Baram"}],"issue":"3","_id":"2669","status":"public","publication_status":"published","intvolume":"        17","month":"03","publisher":"Oxford University Press","publication":"Cerebral Cortex","day":"01","title":"Quantitative analysis and subcellular distribution of mRNA and protein expression of the hyperpolarization-activated cyclic nucleotide-gated channels throughout development in rat hippocampus","year":"2007","citation":{"mla":"Brewster, Amy, et al. “Quantitative Analysis and Subcellular Distribution of MRNA and Protein Expression of the Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels throughout Development in Rat Hippocampus.” <i>Cerebral Cortex</i>, vol. 17, no. 3, Oxford University Press, 2007, pp. 702–12, doi:<a href=\"https://doi.org/10.1093/cercor/bhk021\">10.1093/cercor/bhk021</a>.","short":"A. Brewster, Y. Chen, R. Bender, A. Yeh, R. Shigemoto, T. Baram, Cerebral Cortex 17 (2007) 702–712.","apa":"Brewster, A., Chen, Y., Bender, R., Yeh, A., Shigemoto, R., &#38; Baram, T. (2007). Quantitative analysis and subcellular distribution of mRNA and protein expression of the hyperpolarization-activated cyclic nucleotide-gated channels throughout development in rat hippocampus. <i>Cerebral Cortex</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/cercor/bhk021\">https://doi.org/10.1093/cercor/bhk021</a>","chicago":"Brewster, Amy, Yuncai Chen, Roland Bender, Amy Yeh, Ryuichi Shigemoto, and Tallie Baram. “Quantitative Analysis and Subcellular Distribution of MRNA and Protein Expression of the Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels throughout Development in Rat Hippocampus.” <i>Cerebral Cortex</i>. Oxford University Press, 2007. <a href=\"https://doi.org/10.1093/cercor/bhk021\">https://doi.org/10.1093/cercor/bhk021</a>.","ieee":"A. Brewster, Y. Chen, R. Bender, A. Yeh, R. Shigemoto, and T. Baram, “Quantitative analysis and subcellular distribution of mRNA and protein expression of the hyperpolarization-activated cyclic nucleotide-gated channels throughout development in rat hippocampus,” <i>Cerebral Cortex</i>, vol. 17, no. 3. Oxford University Press, pp. 702–712, 2007.","ama":"Brewster A, Chen Y, Bender R, Yeh A, Shigemoto R, Baram T. Quantitative analysis and subcellular distribution of mRNA and protein expression of the hyperpolarization-activated cyclic nucleotide-gated channels throughout development in rat hippocampus. <i>Cerebral Cortex</i>. 2007;17(3):702-712. doi:<a href=\"https://doi.org/10.1093/cercor/bhk021\">10.1093/cercor/bhk021</a>","ista":"Brewster A, Chen Y, Bender R, Yeh A, Shigemoto R, Baram T. 2007. Quantitative analysis and subcellular distribution of mRNA and protein expression of the hyperpolarization-activated cyclic nucleotide-gated channels throughout development in rat hippocampus. Cerebral Cortex. 17(3), 702–712."},"date_updated":"2021-01-12T06:58:56Z","date_published":"2007-03-01T00:00:00Z","doi":"10.1093/cercor/bhk021","extern":1,"date_created":"2018-12-11T11:58:58Z","type":"journal_article","volume":17,"publist_id":"4229"},{"abstract":[{"lang":"eng","text":"Glutamate and GABA are the main transmitters in the central nervous system and their effects are mediated by ionotropic and metabotropic receptors. Immunogold electron microscopy has revealed the quantitative localization of these receptors at 20-30 nm resolution. SDS-digested freeze-fracture replica labeling (SDS-FRL), a newly developed immunogold method, provides an accurate estimate of molecule numbers. Here, we summarize the recent advances in quantitative receptor localization, including use of SDS-FRL analyses to determine numbers of AMPA-type glutamate receptors in the cerebellum. The two-dimensional view and high sensitivity of SDS-FRL have revealed small, irregularly shaped AMPA receptor clusters within cerebellar synapses."}],"quality_controlled":0,"author":[{"last_name":"Masugi Tokita","full_name":"Masugi-Tokita, Miwako","first_name":"Miwako"},{"orcid":"0000-0001-8761-9444","full_name":"Ryuichi Shigemoto","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto"}],"page":"387 - 393","issue":"3","status":"public","_id":"2670","intvolume":"        17","publication_status":"published","month":"06","publication":"Current Opinion in Neurobiology","publisher":"Elsevier","day":"01","title":"High-resolution quantitative visualization of glutamate and GABA receptors at central synapses","year":"2007","date_updated":"2020-07-14T12:45:44Z","citation":{"short":"M. Masugi Tokita, R. Shigemoto, Current Opinion in Neurobiology 17 (2007) 387–393.","mla":"Masugi Tokita, Miwako, and Ryuichi Shigemoto. “High-Resolution Quantitative Visualization of Glutamate and GABA Receptors at Central Synapses.” <i>Current Opinion in Neurobiology</i>, vol. 17, no. 3, Elsevier, 2007, pp. 387–93, doi:<a href=\"https://doi.org/10.1016/j.conb.2007.04.012\">10.1016/j.conb.2007.04.012</a>.","apa":"Masugi Tokita, M., &#38; Shigemoto, R. (2007). High-resolution quantitative visualization of glutamate and GABA receptors at central synapses. <i>Current Opinion in Neurobiology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.conb.2007.04.012\">https://doi.org/10.1016/j.conb.2007.04.012</a>","chicago":"Masugi Tokita, Miwako, and Ryuichi Shigemoto. “High-Resolution Quantitative Visualization of Glutamate and GABA Receptors at Central Synapses.” <i>Current Opinion in Neurobiology</i>. Elsevier, 2007. <a href=\"https://doi.org/10.1016/j.conb.2007.04.012\">https://doi.org/10.1016/j.conb.2007.04.012</a>.","ieee":"M. Masugi Tokita and R. Shigemoto, “High-resolution quantitative visualization of glutamate and GABA receptors at central synapses,” <i>Current Opinion in Neurobiology</i>, vol. 17, no. 3. Elsevier, pp. 387–393, 2007.","ama":"Masugi Tokita M, Shigemoto R. High-resolution quantitative visualization of glutamate and GABA receptors at central synapses. <i>Current Opinion in Neurobiology</i>. 2007;17(3):387-393. doi:<a href=\"https://doi.org/10.1016/j.conb.2007.04.012\">10.1016/j.conb.2007.04.012</a>","ista":"Masugi Tokita M, Shigemoto R. 2007. High-resolution quantitative visualization of glutamate and GABA receptors at central synapses. Current Opinion in Neurobiology. 17(3), 387–393."},"date_published":"2007-06-01T00:00:00Z","extern":1,"doi":"10.1016/j.conb.2007.04.012","type":"review","date_created":"2018-12-11T11:58:58Z","volume":17,"publist_id":"4226"},{"abstract":[{"text":"Increasing evidence supports roles for the current mediated by hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, I h, in hippocampal maturation and specifically in the evolving changes of intrinsic properties as well as network responses of hippocampal neurons. Here, we describe a novel developmental plasticity of HCN channel expression in axonal and presynaptic compartments: HCN1 channels were localized to axon terminals of the perforant path (the major hippocampal afferent pathway) of immature rats, where they modulated synaptic efficacy. However, presynaptic expression and functions of the channels disappeared with maturation. This was a result of altered channel transport to the axons, because HCN1 mRNA and protein levels in entorhinal cortex neurons, where the perforant path axons originate, were stable through adulthood. Blocking action potential firing in vitro increased presynaptic expression of HCN1 channels in the perforant path, suggesting that network activity contributed to regulating this expression. These findings support a novel developmentally regulated axonal transport of functional ion channels and suggest a role for HCN1 channel-mediated presynaptic I h in hippocampal maturation.","lang":"eng"}],"page":"4697 - 4706","author":[{"last_name":"Bender","full_name":"Bender, Roland A","first_name":"Roland"},{"last_name":"Kirschstein","full_name":"Kirschstein, Timo","first_name":"Timo"},{"last_name":"Kretz","first_name":"Oliver","full_name":"Kretz, Oliver"},{"last_name":"Brewster","first_name":"Amy","full_name":"Brewster, Amy L"},{"last_name":"Richichi","first_name":"Cristina","full_name":"Richichi, Cristina"},{"last_name":"Rüschenschmidt","full_name":"Rüschenschmidt, Christiane","first_name":"Christiane"},{"first_name":"Ryuichi","orcid":"0000-0001-8761-9444","full_name":"Ryuichi Shigemoto","last_name":"Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Beck","full_name":"Beck,Heinz","first_name":"Heinz"},{"full_name":"Frotscher, Michael","first_name":"Michael","last_name":"Frotscher"},{"last_name":"Baram","full_name":"Baram, Tallie Z","first_name":"Tallie"}],"quality_controlled":0,"issue":"17","month":"04","intvolume":"        27","publication_status":"published","_id":"2671","status":"public","day":"25","publication":"Journal of Neuroscience","publisher":"Society for Neuroscience","citation":{"chicago":"Bender, Roland, Timo Kirschstein, Oliver Kretz, Amy Brewster, Cristina Richichi, Christiane Rüschenschmidt, Ryuichi Shigemoto, Heinz Beck, Michael Frotscher, and Tallie Baram. “Localization of HCN1 Channels to Presynaptic Compartments: Novel Plasticity That May Contribute to Hippocampal Maturation.” <i>Journal of Neuroscience</i>. Society for Neuroscience, 2007. <a href=\"https://doi.org/10.1523/JNEUROSCI.4699-06.2007\">https://doi.org/10.1523/JNEUROSCI.4699-06.2007</a>.","mla":"Bender, Roland, et al. “Localization of HCN1 Channels to Presynaptic Compartments: Novel Plasticity That May Contribute to Hippocampal Maturation.” <i>Journal of Neuroscience</i>, vol. 27, no. 17, Society for Neuroscience, 2007, pp. 4697–706, doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.4699-06.2007\">10.1523/JNEUROSCI.4699-06.2007</a>.","short":"R. Bender, T. Kirschstein, O. Kretz, A. Brewster, C. Richichi, C. Rüschenschmidt, R. Shigemoto, H. Beck, M. Frotscher, T. Baram, Journal of Neuroscience 27 (2007) 4697–4706.","apa":"Bender, R., Kirschstein, T., Kretz, O., Brewster, A., Richichi, C., Rüschenschmidt, C., … Baram, T. (2007). Localization of HCN1 channels to presynaptic compartments: Novel plasticity that may contribute to hippocampal maturation. <i>Journal of Neuroscience</i>. Society for Neuroscience. <a href=\"https://doi.org/10.1523/JNEUROSCI.4699-06.2007\">https://doi.org/10.1523/JNEUROSCI.4699-06.2007</a>","ista":"Bender R, Kirschstein T, Kretz O, Brewster A, Richichi C, Rüschenschmidt C, Shigemoto R, Beck H, Frotscher M, Baram T. 2007. Localization of HCN1 channels to presynaptic compartments: Novel plasticity that may contribute to hippocampal maturation. Journal of Neuroscience. 27(17), 4697–4706.","ama":"Bender R, Kirschstein T, Kretz O, et al. Localization of HCN1 channels to presynaptic compartments: Novel plasticity that may contribute to hippocampal maturation. <i>Journal of Neuroscience</i>. 2007;27(17):4697-4706. doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.4699-06.2007\">10.1523/JNEUROSCI.4699-06.2007</a>","ieee":"R. Bender <i>et al.</i>, “Localization of HCN1 channels to presynaptic compartments: Novel plasticity that may contribute to hippocampal maturation,” <i>Journal of Neuroscience</i>, vol. 27, no. 17. Society for Neuroscience, pp. 4697–4706, 2007."},"date_updated":"2021-01-12T06:58:57Z","title":"Localization of HCN1 channels to presynaptic compartments: Novel plasticity that may contribute to hippocampal maturation","year":"2007","doi":"10.1523/JNEUROSCI.4699-06.2007","extern":1,"date_published":"2007-04-25T00:00:00Z","volume":27,"publist_id":"4227","date_created":"2018-12-11T11:58:59Z","type":"journal_article"},{"publication":"Journal of Biological Chemistry","publisher":"American Society for Biochemistry and Molecular Biology","day":"03","year":"2007","title":"HCN2 and HCN4 isoforms self-assemble and co-assemble with equal preference to form functional pacemaker channels","citation":{"apa":"Whitaker, G., Angoli, D., Nazzari, H., Shigemoto, R., &#38; Accili, E. (2007). HCN2 and HCN4 isoforms self-assemble and co-assemble with equal preference to form functional pacemaker channels. <i>Journal of Biological Chemistry</i>. American Society for Biochemistry and Molecular Biology. <a href=\"https://doi.org/10.1074/jbc.M610978200\">https://doi.org/10.1074/jbc.M610978200</a>","mla":"Whitaker, Gina, et al. “HCN2 and HCN4 Isoforms Self-Assemble and Co-Assemble with Equal Preference to Form Functional Pacemaker Channels.” <i>Journal of Biological Chemistry</i>, vol. 282, no. 31, American Society for Biochemistry and Molecular Biology, 2007, pp. 22900–09, doi:<a href=\"https://doi.org/10.1074/jbc.M610978200\">10.1074/jbc.M610978200</a>.","short":"G. Whitaker, D. Angoli, H. Nazzari, R. Shigemoto, E. Accili, Journal of Biological Chemistry 282 (2007) 22900–22909.","chicago":"Whitaker, Gina, Damiano Angoli, Hamed Nazzari, Ryuichi Shigemoto, and Eric Accili. “HCN2 and HCN4 Isoforms Self-Assemble and Co-Assemble with Equal Preference to Form Functional Pacemaker Channels.” <i>Journal of Biological Chemistry</i>. American Society for Biochemistry and Molecular Biology, 2007. <a href=\"https://doi.org/10.1074/jbc.M610978200\">https://doi.org/10.1074/jbc.M610978200</a>.","ama":"Whitaker G, Angoli D, Nazzari H, Shigemoto R, Accili E. HCN2 and HCN4 isoforms self-assemble and co-assemble with equal preference to form functional pacemaker channels. <i>Journal of Biological Chemistry</i>. 2007;282(31):22900-22909. doi:<a href=\"https://doi.org/10.1074/jbc.M610978200\">10.1074/jbc.M610978200</a>","ieee":"G. Whitaker, D. Angoli, H. Nazzari, R. Shigemoto, and E. Accili, “HCN2 and HCN4 isoforms self-assemble and co-assemble with equal preference to form functional pacemaker channels,” <i>Journal of Biological Chemistry</i>, vol. 282, no. 31. American Society for Biochemistry and Molecular Biology, pp. 22900–22909, 2007.","ista":"Whitaker G, Angoli D, Nazzari H, Shigemoto R, Accili E. 2007. HCN2 and HCN4 isoforms self-assemble and co-assemble with equal preference to form functional pacemaker channels. Journal of Biological Chemistry. 282(31), 22900–22909."},"date_updated":"2021-01-12T06:58:58Z","date_published":"2007-08-03T00:00:00Z","extern":1,"doi":"10.1074/jbc.M610978200","type":"journal_article","date_created":"2018-12-11T11:58:59Z","publist_id":"4225","volume":282,"abstract":[{"lang":"eng","text":"Hyperpolarization-activated cyclic nucleotide-modulated (HCN) &quot;pacemaker&quot; channel subunits are integral membrane proteins that assemble as tetramers to form channels in cardiac conduction tissue and nerve cells. Previous studies have suggested that the HCN2 and HCN4 channel isoforms physically interact when overexpressed in mammalian cells, but whether they are able to co-assemble and form functional channels remains unclear. The extent to which co-assembly occurs over self-assembly and whether HCN2-HCN4 heteromeric channels are formed in native tissue are not known. In this study, we show co-assembly of HCN2 and HCN4 in live Chinese hamster ovary cells using bioluminescence resonance energy transfer (BRET2), a novel approach for studying tetramerization of ion channel subunits. Together with results from electrophysiological and imaging approaches, the BRET2 data show that HCN2 and HCN4 subunits self-assemble and co-assemble with equal preference. We also demonstrate colocalization of HCN2 and HCN4 and a positive correlation of their intensities in the embryonic mouse heart using immunohistochemistry, as well as physical interactions between these isoforms in the rat thalamus by coimmunoprecipitation. Together, these data support the formation of HCN2-HCN4 heteromeric channels in native tissue."}],"quality_controlled":0,"author":[{"last_name":"Whitaker","first_name":"Gina","full_name":"Whitaker, Gina M"},{"last_name":"Angoli","full_name":"Angoli, Damiano","first_name":"Damiano"},{"first_name":"Hamed","full_name":"Nazzari, Hamed","last_name":"Nazzari"},{"first_name":"Ryuichi","full_name":"Ryuichi Shigemoto","orcid":"0000-0001-8761-9444","last_name":"Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Accili, Eric A","first_name":"Eric","last_name":"Accili"}],"page":"22900 - 22909","issue":"31","status":"public","_id":"2672","month":"08","intvolume":"       282","publication_status":"published"},{"year":"2007","title":" The coexistence of multiple receptors in a single nerve terminal provides evidence for pre-synaptic integration","citation":{"short":"C. Ladera, M. Godino, R. Martín, R. Luján, R. Shigemoto, F. Ciruela, M. Torres, J. Sánchez Prieto, Journal of Neurochemistry 103 (2007) 2314–2326.","mla":"Ladera, Carolina, et al. “ The Coexistence of Multiple Receptors in a Single Nerve Terminal Provides Evidence for Pre-Synaptic Integration.” <i>Journal of Neurochemistry</i>, vol. 103, no. 6, Wiley-Blackwell, 2007, pp. 2314–26, doi:<a href=\"https://doi.org/10.1111/j.1471-4159.2007.04964.x\">10.1111/j.1471-4159.2007.04964.x</a>.","apa":"Ladera, C., Godino, M., Martín, R., Luján, R., Shigemoto, R., Ciruela, F., … Sánchez Prieto, J. (2007).  The coexistence of multiple receptors in a single nerve terminal provides evidence for pre-synaptic integration. <i>Journal of Neurochemistry</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1111/j.1471-4159.2007.04964.x\">https://doi.org/10.1111/j.1471-4159.2007.04964.x</a>","chicago":"Ladera, Carolina, María Godino, Ricardo Martín, Rafael Luján, Ryuichi Shigemoto, Francisco Ciruela, Magdalena Torres, and José Sánchez Prieto. “ The Coexistence of Multiple Receptors in a Single Nerve Terminal Provides Evidence for Pre-Synaptic Integration.” <i>Journal of Neurochemistry</i>. Wiley-Blackwell, 2007. <a href=\"https://doi.org/10.1111/j.1471-4159.2007.04964.x\">https://doi.org/10.1111/j.1471-4159.2007.04964.x</a>.","ama":"Ladera C, Godino M, Martín R, et al.  The coexistence of multiple receptors in a single nerve terminal provides evidence for pre-synaptic integration. <i>Journal of Neurochemistry</i>. 2007;103(6):2314-2326. doi:<a href=\"https://doi.org/10.1111/j.1471-4159.2007.04964.x\">10.1111/j.1471-4159.2007.04964.x</a>","ieee":"C. Ladera <i>et al.</i>, “ The coexistence of multiple receptors in a single nerve terminal provides evidence for pre-synaptic integration,” <i>Journal of Neurochemistry</i>, vol. 103, no. 6. Wiley-Blackwell, pp. 2314–2326, 2007.","ista":"Ladera C, Godino M, Martín R, Luján R, Shigemoto R, Ciruela F, Torres M, Sánchez Prieto J. 2007.  The coexistence of multiple receptors in a single nerve terminal provides evidence for pre-synaptic integration. Journal of Neurochemistry. 103(6), 2314–2326."},"date_updated":"2021-01-12T06:58:58Z","publisher":"Wiley-Blackwell","publication":"Journal of Neurochemistry","day":"01","date_created":"2018-12-11T11:58:59Z","type":"journal_article","volume":103,"publist_id":"4224","date_published":"2007-12-01T00:00:00Z","doi":"10.1111/j.1471-4159.2007.04964.x","extern":1,"quality_controlled":0,"page":"2314 - 2326","author":[{"full_name":"Ladera, Carolina","first_name":"Carolina","last_name":"Ladera"},{"last_name":"Godino","first_name":"María","full_name":"Godino, María D"},{"full_name":"Martín, Ricardo J","first_name":"Ricardo","last_name":"Martín"},{"first_name":"Rafael","full_name":"Luján, Rafael","last_name":"Luján"},{"orcid":"0000-0001-8761-9444","full_name":"Ryuichi Shigemoto","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto"},{"first_name":"Francisco","full_name":"Ciruela, Francisco","last_name":"Ciruela"},{"last_name":"Torres","first_name":"Magdalena","full_name":"Torres, Magdalena"},{"first_name":"José","full_name":"Sánchez-Prieto, José","last_name":"Sánchez Prieto"}],"abstract":[{"lang":"eng","text":"Excitatory synaptic transmission is inhibited by G protein coupled receptors, including the adenosine A1, GABAB, and metabotropic glutamate receptor 7. These receptors are present in nerve terminals where they reduce the release of glutamate through activating signaling pathways negatively coupled to Ca2+ channels and adenylyl cyclase. However, it is not clear whether these receptors operate in distinct subpopulations of nerve terminals or if they are co-expressed in the same nerve terminals, despite the functional consequences that such distributions may have on synaptic transmission. Applying Ca2+ imaging and immunocytochemistry, we show that these three G protein coupled receptors coexist in a subpopulation of cerebrocortical nerve terminals. The three receptors share an intracellular signaling pathway through which their inhibitory responses are integrated and coactivation of these receptors produced an integrated response. Indeed, this response was highly variable, from a synergistic response at subthreshold agonist concentrations to an occluded response at high agonist concentrations. The presence of multiple receptors in a nerve terminal could be responsible for the physiological effects of neurotransmitter spillover from neighboring synapses or alternatively, the co-release of transmitters by the same nerve terminal."}],"_id":"2673","status":"public","publication_status":"published","month":"12","intvolume":"       103","issue":"6"},{"quality_controlled":0,"page":"401 - 428","author":[{"last_name":"Erdös","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","first_name":"László","full_name":"László Erdös","orcid":"0000-0001-5366-9603"}],"alternative_title":["Proceedings of Symposia in Pure Mathematics"],"_id":"2705","status":"public","intvolume":"        76","publication_status":"published","month":"03","title":"Recent developments in quantum mechanics with magnetic fields","year":"2007","date_updated":"2021-01-12T06:59:10Z","citation":{"ista":"Erdös L. 2007.Recent developments in quantum mechanics with magnetic fields. In: Spectral Theory and Mathematical Physics: a Festschrift in Honor of Barry Simon’s 60th Birthday . Proceedings of Symposia in Pure Mathematics, vol. 76, 401–428.","ama":"Erdös L. Recent developments in quantum mechanics with magnetic fields. In: Gesztesy F, Deift P, Galvez P, Perry P, Schlag W, eds. <i>Spectral Theory and Mathematical Physics: A Festschrift in Honor of Barry Simon’s 60th Birthday </i>. Vol 76. American Mathematical Society; 2007:401-428.","ieee":"L. Erdös, “Recent developments in quantum mechanics with magnetic fields,” in <i>Spectral Theory and Mathematical Physics: a Festschrift in Honor of Barry Simon’s 60th Birthday </i>, vol. 76, F. Gesztesy, P. Deift, P. Galvez, P. Perry, and W. Schlag, Eds. American Mathematical Society, 2007, pp. 401–428.","chicago":"Erdös, László. “Recent Developments in Quantum Mechanics with Magnetic Fields.” In <i>Spectral Theory and Mathematical Physics: A Festschrift in Honor of Barry Simon’s 60th Birthday </i>, edited by Fritz Gesztesy, Percy Deift, Percy Galvez, Peter Perry, and Wilhelm Schlag, 76:401–28. American Mathematical Society, 2007.","apa":"Erdös, L. (2007). Recent developments in quantum mechanics with magnetic fields. In F. Gesztesy, P. Deift, P. Galvez, P. Perry, &#38; W. Schlag (Eds.), <i>Spectral Theory and Mathematical Physics: a Festschrift in Honor of Barry Simon’s 60th Birthday </i> (Vol. 76, pp. 401–428). American Mathematical Society.","short":"L. Erdös, in:, F. Gesztesy, P. Deift, P. Galvez, P. Perry, W. Schlag (Eds.), Spectral Theory and Mathematical Physics: A Festschrift in Honor of Barry Simon’s 60th Birthday , American Mathematical Society, 2007, pp. 401–428.","mla":"Erdös, László. “Recent Developments in Quantum Mechanics with Magnetic Fields.” <i>Spectral Theory and Mathematical Physics: A Festschrift in Honor of Barry Simon’s 60th Birthday </i>, edited by Fritz Gesztesy et al., vol. 76, American Mathematical Society, 2007, pp. 401–28."},"main_file_link":[{"open_access":"1","url":"http://arxiv.org/abs/math-ph/0510055v2"}],"publication":"Spectral Theory and Mathematical Physics: a Festschrift in Honor of Barry Simon's 60th Birthday ","publisher":"American Mathematical Society","day":"30","oa":1,"date_created":"2018-12-11T11:59:10Z","type":"book_chapter","publist_id":"4191","volume":76,"editor":[{"last_name":"Gesztesy","first_name":"Fritz","full_name":"Gesztesy, Fritz"},{"last_name":"Deift","first_name":"Percy","full_name":"Deift, Percy"},{"full_name":"Galvez, Percy","first_name":"Percy","last_name":"Galvez"},{"last_name":"Perry","first_name":"Peter","full_name":"Perry, Peter"},{"last_name":"Schlag","full_name":"Schlag, Wilhelm","first_name":"Wilhelm"}],"date_published":"2007-03-30T00:00:00Z","extern":1},{"year":"2007","title":"Rigorous derivation of the Gross-Pitaevskii equation","citation":{"ista":"Erdös L, Schlein B, Yau H. 2007. Rigorous derivation of the Gross-Pitaevskii equation. Physical Review Letters. 98(4).","ieee":"L. Erdös, B. Schlein, and H. Yau, “Rigorous derivation of the Gross-Pitaevskii equation,” <i>Physical Review Letters</i>, vol. 98, no. 4. American Physical Society, 2007.","ama":"Erdös L, Schlein B, Yau H. Rigorous derivation of the Gross-Pitaevskii equation. <i>Physical Review Letters</i>. 2007;98(4). doi:<a href=\"https://doi.org/10.1103/PhysRevLett.98.040404\">10.1103/PhysRevLett.98.040404</a>","chicago":"Erdös, László, Benjamin Schlein, and Horng Yau. “Rigorous Derivation of the Gross-Pitaevskii Equation.” <i>Physical Review Letters</i>. American Physical Society, 2007. <a href=\"https://doi.org/10.1103/PhysRevLett.98.040404\">https://doi.org/10.1103/PhysRevLett.98.040404</a>.","mla":"Erdös, László, et al. “Rigorous Derivation of the Gross-Pitaevskii Equation.” <i>Physical Review Letters</i>, vol. 98, no. 4, American Physical Society, 2007, doi:<a href=\"https://doi.org/10.1103/PhysRevLett.98.040404\">10.1103/PhysRevLett.98.040404</a>.","short":"L. Erdös, B. Schlein, H. Yau, Physical Review Letters 98 (2007).","apa":"Erdös, L., Schlein, B., &#38; Yau, H. (2007). Rigorous derivation of the Gross-Pitaevskii equation. <i>Physical Review Letters</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevLett.98.040404\">https://doi.org/10.1103/PhysRevLett.98.040404</a>"},"date_updated":"2021-01-12T06:59:26Z","publisher":"American Physical Society","publication":"Physical Review Letters","day":"26","type":"journal_article","date_created":"2018-12-11T11:59:23Z","publist_id":"4144","volume":98,"date_published":"2007-01-26T00:00:00Z","extern":1,"doi":"10.1103/PhysRevLett.98.040404","quality_controlled":0,"author":[{"full_name":"László Erdös","orcid":"0000-0001-5366-9603","first_name":"László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","last_name":"Erdös"},{"first_name":"Benjamin","full_name":"Schlein, Benjamin","last_name":"Schlein"},{"first_name":"Horng","full_name":"Yau, Horng-Tzer","last_name":"Yau"}],"abstract":[{"text":"The time-dependent Gross-Pitaevskii equation describes the dynamics of initially trapped Bose-Einstein condensates. We present a rigorous proof of this fact starting from a many-body bosonic Schrödinger equation with a short-scale repulsive interaction in the dilute limit. Our proof shows the persistence of an explicit short-scale correlation structure in the condensate.","lang":"eng"}],"status":"public","_id":"2748","publication_status":"published","month":"01","intvolume":"        98","issue":"4"},{"publication_status":"published","month":"03","intvolume":"       167","_id":"2749","status":"public","issue":"3","page":"515 - 614","author":[{"last_name":"Erdös","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","first_name":"László","orcid":"0000-0001-5366-9603","full_name":"László Erdös"},{"first_name":"Benjamin","full_name":"Schlein, Benjamin","last_name":"Schlein"},{"first_name":"Horng","full_name":"Yau, Horng-Tzer","last_name":"Yau"}],"quality_controlled":0,"abstract":[{"text":"We prove rigorously that the one-particle density matrix of three dimensional interacting Bose systems with a short-scale repulsive pair interaction converges to the solution of the cubic non-linear Schrödinger equation in a suitable scaling limit. The result is extended to k-particle density matrices for all positive integer k. ","lang":"eng"}],"volume":167,"publist_id":"4143","date_created":"2018-12-11T11:59:24Z","type":"review","doi":"10.1007/s00222-006-0022-1","extern":1,"date_published":"2007-03-01T00:00:00Z","date_updated":"2019-04-26T07:22:19Z","citation":{"chicago":"Erdös, László, Benjamin Schlein, and Horng Yau. “Derivation of the Cubic Non Linear Schrödinger Equation from Quantum Dynamics of Many Body Systems.” <i>Inventiones Mathematicae</i>. Springer, 2007. <a href=\"https://doi.org/10.1007/s00222-006-0022-1\">https://doi.org/10.1007/s00222-006-0022-1</a>.","apa":"Erdös, L., Schlein, B., &#38; Yau, H. (2007). Derivation of the cubic non linear Schrödinger equation from quantum dynamics of many body systems. <i>Inventiones Mathematicae</i>. Springer. <a href=\"https://doi.org/10.1007/s00222-006-0022-1\">https://doi.org/10.1007/s00222-006-0022-1</a>","mla":"Erdös, László, et al. “Derivation of the Cubic Non Linear Schrödinger Equation from Quantum Dynamics of Many Body Systems.” <i>Inventiones Mathematicae</i>, vol. 167, no. 3, Springer, 2007, pp. 515–614, doi:<a href=\"https://doi.org/10.1007/s00222-006-0022-1\">10.1007/s00222-006-0022-1</a>.","short":"L. Erdös, B. Schlein, H. Yau, Inventiones Mathematicae 167 (2007) 515–614.","ista":"Erdös L, Schlein B, Yau H. 2007. Derivation of the cubic non linear Schrödinger equation from quantum dynamics of many body systems. Inventiones Mathematicae. 167(3), 515–614.","ama":"Erdös L, Schlein B, Yau H. Derivation of the cubic non linear Schrödinger equation from quantum dynamics of many body systems. <i>Inventiones Mathematicae</i>. 2007;167(3):515-614. doi:<a href=\"https://doi.org/10.1007/s00222-006-0022-1\">10.1007/s00222-006-0022-1</a>","ieee":"L. Erdös, B. Schlein, and H. Yau, “Derivation of the cubic non linear Schrödinger equation from quantum dynamics of many body systems,” <i>Inventiones Mathematicae</i>, vol. 167, no. 3. Springer, pp. 515–614, 2007."},"year":"2007","title":"Derivation of the cubic non linear Schrödinger equation from quantum dynamics of many body systems","day":"01","publication":"Inventiones Mathematicae","publisher":"Springer"}]