[{"publisher":"World Scientific Publishing","main_file_link":[{"url":"http://arxiv.org/abs/0806.4751","open_access":"1"}],"oa":1,"day":"01","title":"Feynman graphs and renormalization in quantum diffusion","year":"2008","citation":{"ama":"Erdös L, Salmhofer M, Yau H. Feynman graphs and renormalization in quantum diffusion. In: World Scientific Publishing; 2008:167-182. doi:<a href=\"https://doi.org/10.1142/9789812833556_0011\">10.1142/9789812833556_0011</a>","ieee":"L. Erdös, M. Salmhofer, and H. Yau, “Feynman graphs and renormalization in quantum diffusion,” presented at the Symposium in Honor of Wolfhart Zimmermann’s 80th Birthday, 2008, pp. 167–182.","ista":"Erdös L, Salmhofer M, Yau H. 2008. Feynman graphs and renormalization in quantum diffusion. Symposium in Honor of Wolfhart Zimmermann’s 80th Birthday, 167–182.","mla":"Erdös, László, et al. <i>Feynman Graphs and Renormalization in Quantum Diffusion</i>. World Scientific Publishing, 2008, pp. 167–82, doi:<a href=\"https://doi.org/10.1142/9789812833556_0011\">10.1142/9789812833556_0011</a>.","short":"L. Erdös, M. Salmhofer, H. Yau, in:, World Scientific Publishing, 2008, pp. 167–182.","apa":"Erdös, L., Salmhofer, M., &#38; Yau, H. (2008). Feynman graphs and renormalization in quantum diffusion (pp. 167–182). Presented at the Symposium in Honor of Wolfhart Zimmermann’s 80th Birthday, World Scientific Publishing. <a href=\"https://doi.org/10.1142/9789812833556_0011\">https://doi.org/10.1142/9789812833556_0011</a>","chicago":"Erdös, László, Manfred Salmhofer, and Horng Yau. “Feynman Graphs and Renormalization in Quantum Diffusion,” 167–82. World Scientific Publishing, 2008. <a href=\"https://doi.org/10.1142/9789812833556_0011\">https://doi.org/10.1142/9789812833556_0011</a>."},"date_updated":"2021-01-12T06:59:09Z","date_published":"2008-01-01T00:00:00Z","extern":1,"doi":"10.1142/9789812833556_0011","type":"conference","date_created":"2018-12-11T11:59:09Z","publist_id":"4194","abstract":[{"lang":"eng","text":"We review our proof that in a scaling limit, the time evolution of a quantum particle in a static random environment leads to a diffusion equation. In particular, we discuss the role of Feynman graph expansions and of renormalization.\n"}],"quality_controlled":0,"author":[{"first_name":"László","full_name":"László Erdös","orcid":"0000-0001-5366-9603","last_name":"Erdös","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Salmhofer, Manfred","first_name":"Manfred","last_name":"Salmhofer"},{"last_name":"Yau","full_name":"Yau, Horng-Tzer","first_name":"Horng"}],"page":"167 - 182","conference":{"name":"Symposium in Honor of Wolfhart Zimmermann's 80th Birthday"},"status":"public","_id":"2702","month":"01","publication_status":"published"},{"issue":"2","status":"public","_id":"2753","publication_status":"published","intvolume":"       200","month":"07","abstract":[{"lang":"eng","text":"We consider random Schrödinger equations on R d for d ≽ 3 with a homogeneous Anderson–Poisson type random potential. Denote by λ the coupling constant and ψt the solution with initial data ψ0 . The space and time variables scale as x∼λ−2−ϰ/2 and t∼λ−2−ϰ with 0&lt;ϰ&lt;ϰ0(d) . We prove that, in the limit λ → 0, the expectation of the Wigner distribution of ψt converges weakly to the solution of a heat equation in the space variable x for arbitrary L 2 initial data.\nThe proof is based on analyzing the phase cancellations of multiple scatterings on the random potential by expanding the propagator into a sum of Feynman graphs. In this paper we consider the non-recollision graphs and prove that the amplitude of the non-ladder diagrams is smaller than their “naive size” by an extra λ c factor per non-(anti)ladder vertex for some c &gt; 0. This is the first rigorous result showing that the improvement over the naive estimates on the Feynman graphs grows as a power of the small parameter with the exponent depending linearly on the number of vertices. This estimate allows us to prove the convergence of the perturbation series.\n"}],"quality_controlled":0,"author":[{"id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","last_name":"Erdös","full_name":"László Erdös","orcid":"0000-0001-5366-9603","first_name":"László"},{"last_name":"Salmhofer","full_name":"Salmhofer, Manfred","first_name":"Manfred"},{"full_name":"Yau, Horng-Tzer","first_name":"Horng","last_name":"Yau"}],"page":"211 - 277","date_published":"2008-07-01T00:00:00Z","extern":1,"doi":"10.1007/s11511-008-0027-2","type":"journal_article","date_created":"2018-12-11T11:59:25Z","volume":200,"publist_id":"4139","publication":"Acta Mathematica","publisher":"Springer","day":"01","year":"2008","title":"Quantum diffusion of the random Schrödinger evolution in the scaling limit","date_updated":"2021-01-12T06:59:28Z","citation":{"ista":"Erdös L, Salmhofer M, Yau H. 2008. Quantum diffusion of the random Schrödinger evolution in the scaling limit. Acta Mathematica. 200(2), 211–277.","ieee":"L. Erdös, M. Salmhofer, and H. Yau, “Quantum diffusion of the random Schrödinger evolution in the scaling limit,” <i>Acta Mathematica</i>, vol. 200, no. 2. Springer, pp. 211–277, 2008.","ama":"Erdös L, Salmhofer M, Yau H. Quantum diffusion of the random Schrödinger evolution in the scaling limit. <i>Acta Mathematica</i>. 2008;200(2):211-277. doi:<a href=\"https://doi.org/10.1007/s11511-008-0027-2\">10.1007/s11511-008-0027-2</a>","chicago":"Erdös, László, Manfred Salmhofer, and Horng Yau. “Quantum Diffusion of the Random Schrödinger Evolution in the Scaling Limit.” <i>Acta Mathematica</i>. Springer, 2008. <a href=\"https://doi.org/10.1007/s11511-008-0027-2\">https://doi.org/10.1007/s11511-008-0027-2</a>.","short":"L. Erdös, M. Salmhofer, H. Yau, Acta Mathematica 200 (2008) 211–277.","mla":"Erdös, László, et al. “Quantum Diffusion of the Random Schrödinger Evolution in the Scaling Limit.” <i>Acta Mathematica</i>, vol. 200, no. 2, Springer, 2008, pp. 211–77, doi:<a href=\"https://doi.org/10.1007/s11511-008-0027-2\">10.1007/s11511-008-0027-2</a>.","apa":"Erdös, L., Salmhofer, M., &#38; Yau, H. (2008). Quantum diffusion of the random Schrödinger evolution in the scaling limit. <i>Acta Mathematica</i>. Springer. <a href=\"https://doi.org/10.1007/s11511-008-0027-2\">https://doi.org/10.1007/s11511-008-0027-2</a>"}},{"issue":"2","_id":"2754","status":"public","month":"07","publication_status":"published","intvolume":"       132","abstract":[{"text":"We study the dynamics of an electron weakly coupled to a phonon gas. The initial state of the electron is the superposition of two spatially localized distant bumps moving towards each other, and the phonons are in a thermal state. We investigate the dynamics of the system in the kinetic regime and show that the time evolution makes the non-diagonal terms of the density matrix of the electron decay, destroying the interference between the two bumps. We show that such a damping effect is exponential in time, and the related decay rate is proportional to the total scattering cross section of the electron-phonon interaction.","lang":"eng"}],"quality_controlled":0,"page":"301 - 328","author":[{"full_name":"Adami, Riccardo","first_name":"Riccardo","last_name":"Adami"},{"full_name":"László Erdös","orcid":"0000-0001-5366-9603","first_name":"László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","last_name":"Erdös"}],"date_published":"2008-07-01T00:00:00Z","doi":"10.1007/s10955-008-9561-8","extern":1,"date_created":"2018-12-11T11:59:25Z","type":"journal_article","volume":132,"publist_id":"4138","publication":"Journal of Statistical Physics","publisher":"Springer","day":"01","year":"2008","title":"Rate of decoherence for an electron weakly coupled to a phonon gas","date_updated":"2021-01-12T06:59:28Z","citation":{"chicago":"Adami, Riccardo, and László Erdös. “Rate of Decoherence for an Electron Weakly Coupled to a Phonon Gas.” <i>Journal of Statistical Physics</i>. Springer, 2008. <a href=\"https://doi.org/10.1007/s10955-008-9561-8\">https://doi.org/10.1007/s10955-008-9561-8</a>.","apa":"Adami, R., &#38; Erdös, L. (2008). Rate of decoherence for an electron weakly coupled to a phonon gas. <i>Journal of Statistical Physics</i>. Springer. <a href=\"https://doi.org/10.1007/s10955-008-9561-8\">https://doi.org/10.1007/s10955-008-9561-8</a>","short":"R. Adami, L. Erdös, Journal of Statistical Physics 132 (2008) 301–328.","mla":"Adami, Riccardo, and László Erdös. “Rate of Decoherence for an Electron Weakly Coupled to a Phonon Gas.” <i>Journal of Statistical Physics</i>, vol. 132, no. 2, Springer, 2008, pp. 301–28, doi:<a href=\"https://doi.org/10.1007/s10955-008-9561-8\">10.1007/s10955-008-9561-8</a>.","ista":"Adami R, Erdös L. 2008. Rate of decoherence for an electron weakly coupled to a phonon gas. Journal of Statistical Physics. 132(2), 301–328.","ama":"Adami R, Erdös L. Rate of decoherence for an electron weakly coupled to a phonon gas. <i>Journal of Statistical Physics</i>. 2008;132(2):301-328. doi:<a href=\"https://doi.org/10.1007/s10955-008-9561-8\">10.1007/s10955-008-9561-8</a>","ieee":"R. Adami and L. Erdös, “Rate of decoherence for an electron weakly coupled to a phonon gas,” <i>Journal of Statistical Physics</i>, vol. 132, no. 2. Springer, pp. 301–328, 2008."}},{"date_updated":"2021-01-12T06:59:29Z","citation":{"apa":"Erdös, L., Schlein, B., &#38; Yau, H. (2008). Ground-state energy of a low-density Bose gas: A second-order upper bound. <i>Physical Review A - Atomic, Molecular, and Optical Physics</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevA.78.053627\">https://doi.org/10.1103/PhysRevA.78.053627</a>","short":"L. Erdös, B. Schlein, H. Yau, Physical Review A - Atomic, Molecular, and Optical Physics 78 (2008).","mla":"Erdös, László, et al. “Ground-State Energy of a Low-Density Bose Gas: A Second-Order Upper Bound.” <i>Physical Review A - Atomic, Molecular, and Optical Physics</i>, vol. 78, no. 5, American Physical Society, 2008, doi:<a href=\"https://doi.org/10.1103/PhysRevA.78.053627\">10.1103/PhysRevA.78.053627</a>.","chicago":"Erdös, László, Benjamin Schlein, and Horng Yau. “Ground-State Energy of a Low-Density Bose Gas: A Second-Order Upper Bound.” <i>Physical Review A - Atomic, Molecular, and Optical Physics</i>. American Physical Society, 2008. <a href=\"https://doi.org/10.1103/PhysRevA.78.053627\">https://doi.org/10.1103/PhysRevA.78.053627</a>.","ieee":"L. Erdös, B. Schlein, and H. Yau, “Ground-state energy of a low-density Bose gas: A second-order upper bound,” <i>Physical Review A - Atomic, Molecular, and Optical Physics</i>, vol. 78, no. 5. American Physical Society, 2008.","ama":"Erdös L, Schlein B, Yau H. Ground-state energy of a low-density Bose gas: A second-order upper bound. <i>Physical Review A - Atomic, Molecular, and Optical Physics</i>. 2008;78(5). doi:<a href=\"https://doi.org/10.1103/PhysRevA.78.053627\">10.1103/PhysRevA.78.053627</a>","ista":"Erdös L, Schlein B, Yau H. 2008. Ground-state energy of a low-density Bose gas: A second-order upper bound. Physical Review A - Atomic, Molecular, and Optical Physics. 78(5)."},"year":"2008","title":"Ground-state energy of a low-density Bose gas: A second-order upper bound","day":"01","publisher":"American Physical Society","publication":"Physical Review A - Atomic, Molecular, and Optical Physics","volume":78,"publist_id":"4137","type":"journal_article","date_created":"2018-12-11T11:59:26Z","extern":1,"doi":"10.1103/PhysRevA.78.053627","date_published":"2008-01-01T00:00:00Z","author":[{"last_name":"Erdös","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","first_name":"László","orcid":"0000-0001-5366-9603","full_name":"László Erdös"},{"last_name":"Schlein","first_name":"Benjamin","full_name":"Schlein, Benjamin"},{"full_name":"Yau, Horng-Tzer","first_name":"Horng","last_name":"Yau"}],"quality_controlled":0,"abstract":[{"text":"Consider N bosons in a finite box Λ= [0,L]3⊂ R3 interacting via a two-body non-negative soft potential V=λ V with V fixed and λ&gt;0 small. We will take the limit L,N→∞ by keeping the density =N/L3 fixed and small. We construct a variational state, which gives an upper bound on the ground-state energy per particle ε, ε≤4πa [1+ (128/15π) (a3) 1/2 Sλ] +O (2 ln ), as →0, with a constant satisfying 1≤ Sλ ≤1+Cλ. Here a is the scattering length of V and thus depends on λ. In comparison, the prediction by Lee and Yang [Phys. Rev. 105, 1119 (1957)] and Lee, Huang, and Yang [Phys. Rev. 106, 1135 (1957)] asserts that Sλ =1 independent of λ.","lang":"eng"}],"month":"01","publication_status":"published","intvolume":"        78","status":"public","_id":"2755","issue":"5"},{"author":[{"first_name":"Björn","orcid":"0000-0003-2057-2754","full_name":"Björn Hof","last_name":"Hof","id":"3A374330-F248-11E8-B48F-1D18A9856A87"},{"last_name":"De Lózar","full_name":"de Lózar, Alberto","first_name":"Alberto"},{"last_name":"Kuik","full_name":"Kuik, Dirk J","first_name":"Dirk"},{"full_name":"Westerweel, Jerry","first_name":"Jerry","last_name":"Westerweel"}],"quality_controlled":0,"abstract":[{"text":"The collapse of turbulence, observable in shear flows at low Reynolds numbers, raises the question if turbulence is generically of a transient nature or becomes sustained at some critical point. Recent data have led to conflicting views with the majority of studies supporting the model of turbulence turning into an attracting state. Here we present lifetime measurements of turbulence in pipe flow spanning 8 orders of magnitude in time, drastically extending all previous investigations. We show that no critical point exists in this regime and that in contrast to the prevailing view the turbulent state remains transient. To our knowledge this is the first observation of superexponential transients in turbulence, confirming a conjecture derived from low-dimensional systems.","lang":"eng"}],"publication_status":"published","intvolume":"       101","month":"11","_id":"2795","status":"public","issue":"21","date_updated":"2021-01-12T06:59:46Z","citation":{"mla":"Hof, Björn, et al. “Repeller or Attractor? Selecting the Dynamical Model for the Onset of Turbulence in Pipe Flow.” <i>Physical Review Letters</i>, vol. 101, no. 21, American Physical Society, 2008, doi:<a href=\"https://doi.org/10.1103/PhysRevLett.101.214501\">10.1103/PhysRevLett.101.214501</a>.","short":"B. Hof, A. De Lózar, D. Kuik, J. Westerweel, Physical Review Letters 101 (2008).","apa":"Hof, B., De Lózar, A., Kuik, D., &#38; Westerweel, J. (2008). Repeller or attractor? Selecting the dynamical model for the onset of turbulence in pipe flow. <i>Physical Review Letters</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevLett.101.214501\">https://doi.org/10.1103/PhysRevLett.101.214501</a>","chicago":"Hof, Björn, Alberto De Lózar, Dirk Kuik, and Jerry Westerweel. “Repeller or Attractor? Selecting the Dynamical Model for the Onset of Turbulence in Pipe Flow.” <i>Physical Review Letters</i>. American Physical Society, 2008. <a href=\"https://doi.org/10.1103/PhysRevLett.101.214501\">https://doi.org/10.1103/PhysRevLett.101.214501</a>.","ama":"Hof B, De Lózar A, Kuik D, Westerweel J. Repeller or attractor? Selecting the dynamical model for the onset of turbulence in pipe flow. <i>Physical Review Letters</i>. 2008;101(21). doi:<a href=\"https://doi.org/10.1103/PhysRevLett.101.214501\">10.1103/PhysRevLett.101.214501</a>","ieee":"B. Hof, A. De Lózar, D. Kuik, and J. Westerweel, “Repeller or attractor? Selecting the dynamical model for the onset of turbulence in pipe flow,” <i>Physical Review Letters</i>, vol. 101, no. 21. American Physical Society, 2008.","ista":"Hof B, De Lózar A, Kuik D, Westerweel J. 2008. Repeller or attractor? Selecting the dynamical model for the onset of turbulence in pipe flow. Physical Review Letters. 101(21)."},"year":"2008","title":"Repeller or attractor? Selecting the dynamical model for the onset of turbulence in pipe flow","day":"18","publication":"Physical Review Letters","publisher":"American Physical Society","volume":101,"publist_id":"4094","date_created":"2018-12-11T11:59:38Z","type":"journal_article","doi":"10.1103/PhysRevLett.101.214501","extern":1,"date_published":"2008-11-18T00:00:00Z"},{"type":"journal_article","date_created":"2018-12-11T12:00:11Z","publist_id":"3866","volume":10,"date_published":"2008-01-01T00:00:00Z","extern":1,"doi":"10.1111/j.1525-142X.2008.00265.x","title":"Networking networks","year":"2008","citation":{"chicago":"Azevedo, Ricardo, Rolf Lohaus, and Tiago Paixao. “Networking Networks.” <i>Evolution &#38; Development</i>. Wiley-Blackwell, 2008. <a href=\"https://doi.org/10.1111/j.1525-142X.2008.00265.x\">https://doi.org/10.1111/j.1525-142X.2008.00265.x</a>.","apa":"Azevedo, R., Lohaus, R., &#38; Paixao, T. (2008). Networking networks. <i>Evolution &#38; Development</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1111/j.1525-142X.2008.00265.x\">https://doi.org/10.1111/j.1525-142X.2008.00265.x</a>","mla":"Azevedo, Ricardo, et al. “Networking Networks.” <i>Evolution &#38; Development</i>, vol. 10, no. 5, Wiley-Blackwell, 2008, pp. 514–15, doi:<a href=\"https://doi.org/10.1111/j.1525-142X.2008.00265.x\">10.1111/j.1525-142X.2008.00265.x</a>.","short":"R. Azevedo, R. Lohaus, T. Paixao, Evolution &#38; Development 10 (2008) 514–515.","ista":"Azevedo R, Lohaus R, Paixao T. 2008. Networking networks. Evolution &#38; Development. 10(5), 514–515.","ieee":"R. Azevedo, R. Lohaus, and T. Paixao, “Networking networks,” <i>Evolution &#38; Development</i>, vol. 10, no. 5. Wiley-Blackwell, pp. 514–515, 2008.","ama":"Azevedo R, Lohaus R, Paixao T. Networking networks. <i>Evolution &#38; Development</i>. 2008;10(5):514-515. doi:<a href=\"https://doi.org/10.1111/j.1525-142X.2008.00265.x\">10.1111/j.1525-142X.2008.00265.x</a>"},"date_updated":"2021-01-12T07:00:31Z","publication":"Evolution & Development","publisher":"Wiley-Blackwell","day":"01","status":"public","_id":"2892","intvolume":"        10","month":"01","publication_status":"published","issue":"5","quality_controlled":0,"author":[{"last_name":"Azevedo","first_name":"Ricardo","full_name":"Azevedo, Ricardo B"},{"last_name":"Lohaus","first_name":"Rolf","full_name":"Lohaus, Rolf"},{"id":"2C5658E6-F248-11E8-B48F-1D18A9856A87","last_name":"Paixao","orcid":"0000-0003-2361-3953","full_name":"Tiago Paixao","first_name":"Tiago"}],"page":"514 - 515"},{"status":"public","_id":"3030","publication_status":"published","intvolume":"        66","month":"04","issue":"6","quality_controlled":0,"author":[{"last_name":"Růčková","full_name":"Růčková, Eva","first_name":"Eva"},{"orcid":"0000-0002-8302-7596","full_name":"Jirí Friml","first_name":"Jirí","id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml"},{"first_name":"Petra","full_name":"Procházková Schrumpfová, Petra","last_name":"Procházková Schrumpfová"},{"first_name":"Jiří","full_name":"Fajkus, Jiří","last_name":"Fajkus"}],"page":"637 - 646","abstract":[{"lang":"eng","text":"Telomeres in many eukaryotes are maintained by telomerase in whose absence telomere shortening occurs. However, telomerase-deficient Arabidopsis thaliana mutants (Attert -/-) show extremely low rates of telomere shortening per plant generation (250-500 bp), which does not correspond to the expected outcome of replicative telomere shortening resulting from ca. 1,000 meristem cell divisions per seed-to-seed generation. To investigate the influence of the number of cell divisions per seed-to-seed generation, Attert -/- mutant plants were propagated from seeds coming either from the lower-most or the upper-most siliques (L- and U-plants) and the length of their telomeres were followed over several generations. The rate of telomere shortening was faster in U-plants, than in L-plants, as would be expected from their higher number of cell divisions per generation. However, this trend was observed only in telomeres whose initial length is relatively high and the differences decreased with progressive general telomere shortening over generations. But in generation 4, the L-plants frequently show a net telomere elongation, while the U-plants fail to do so. We propose that this is due to the activation of alternative telomere lengthening (ALT), a process which is activated in early embryonic development in both U- and L-plants, but is overridden in U-plants due to their higher number of cell divisions per generation. These data demonstrate what so far has only been speculated, that in the absence of telomerase, the number of cell divisions within one generation influences the control of telomere lengths. These results also reveal a fast and efficient activation of ALT mechanism(s) in response to the loss of telomerase activity and imply that ALT is probably involved also in normal plant development."}],"type":"journal_article","date_created":"2018-12-11T12:00:57Z","volume":66,"publist_id":"3671","date_published":"2008-04-01T00:00:00Z","extern":1,"doi":"10.1007/s11103-008-9295-7","year":"2008","title":"Role of alternative telomere lengthening unmasked in telomerase knock-out mutant plants","citation":{"ista":"Růčková E, Friml J, Procházková Schrumpfová P, Fajkus J. 2008. Role of alternative telomere lengthening unmasked in telomerase knock-out mutant plants. Plant Molecular Biology. 66(6), 637–646.","ieee":"E. Růčková, J. Friml, P. Procházková Schrumpfová, and J. Fajkus, “Role of alternative telomere lengthening unmasked in telomerase knock-out mutant plants,” <i>Plant Molecular Biology</i>, vol. 66, no. 6. Springer, pp. 637–646, 2008.","ama":"Růčková E, Friml J, Procházková Schrumpfová P, Fajkus J. Role of alternative telomere lengthening unmasked in telomerase knock-out mutant plants. <i>Plant Molecular Biology</i>. 2008;66(6):637-646. doi:<a href=\"https://doi.org/10.1007/s11103-008-9295-7\">10.1007/s11103-008-9295-7</a>","chicago":"Růčková, Eva, Jiří Friml, Petra Procházková Schrumpfová, and Jiří Fajkus. “Role of Alternative Telomere Lengthening Unmasked in Telomerase Knock-out Mutant Plants.” <i>Plant Molecular Biology</i>. Springer, 2008. <a href=\"https://doi.org/10.1007/s11103-008-9295-7\">https://doi.org/10.1007/s11103-008-9295-7</a>.","apa":"Růčková, E., Friml, J., Procházková Schrumpfová, P., &#38; Fajkus, J. (2008). Role of alternative telomere lengthening unmasked in telomerase knock-out mutant plants. <i>Plant Molecular Biology</i>. Springer. <a href=\"https://doi.org/10.1007/s11103-008-9295-7\">https://doi.org/10.1007/s11103-008-9295-7</a>","short":"E. Růčková, J. Friml, P. Procházková Schrumpfová, J. Fajkus, Plant Molecular Biology 66 (2008) 637–646.","mla":"Růčková, Eva, et al. “Role of Alternative Telomere Lengthening Unmasked in Telomerase Knock-out Mutant Plants.” <i>Plant Molecular Biology</i>, vol. 66, no. 6, Springer, 2008, pp. 637–46, doi:<a href=\"https://doi.org/10.1007/s11103-008-9295-7\">10.1007/s11103-008-9295-7</a>."},"date_updated":"2021-01-12T07:40:34Z","publisher":"Springer","publication":"Plant Molecular Biology","day":"01"},{"abstract":[{"lang":"eng","text":"Many aspects of plant development, including patterning and tropisms, are largely dependent on the asymmetric distribution of the plant signaling molecule auxin. Auxin transport inhibitors (ATIs), which interfere with directional auxin transport, have been essential tools in formulating this concept. However, despite the use of ATIs in plant research for many decades, the mechanism of ATI action has remained largely elusive. Using real-time live-cell microscopy, we show here that prominent ATIs such as 2,3,5-triiodobenzoic acid (TIBA) and 2-(1-pyrenoyl) benzoic acid (PBA) inhibit vesicle trafficking in plant, yeast, and mammalian cells. Effects on micropinocytosis, rab5-labeled endosomal motility at the periphery of HeLa cells and on fibroblast mobility indicate that ATIs influence actin cytoskeleton. Visualization of actin cytoskeleton dynamics in plants, yeast, and mammalian cells show that ATIs stabilize actin. Conversely, stabilizing actin by chemical or genetic means interferes with endocytosis, vesicle motility, auxin transport, and plant development, including auxin transport-dependent processes. Our results show that a class of ATIs act as actin stabilizers and advocate that actin-dependent trafficking of auxin transport components participates in the mechanism of auxin transport. These studies also provide an example of how the common eukaryotic process of actin-based vesicle motility can fulfill a plant-specific physiological role."}],"page":"4489 - 4494","author":[{"last_name":"Dhonukshe","full_name":"Dhonukshe, Pankaj","first_name":"Pankaj"},{"last_name":"Grigoriev","first_name":"Ilya","full_name":"Grigoriev, Ilya S"},{"last_name":"Fischer","full_name":"Fischer, Rainer","first_name":"Rainer"},{"first_name":"Motoki","full_name":"Tominaga, Motoki","last_name":"Tominaga"},{"last_name":"Robinson","first_name":"David","full_name":"Robinson, David G"},{"last_name":"Hašek","full_name":"Hašek, Jiří","first_name":"Jiří"},{"full_name":"Paciorek, Tomasz","first_name":"Tomasz","last_name":"Paciorek"},{"last_name":"Petrášek","full_name":"Petrášek, Jan","first_name":"Jan"},{"last_name":"Seifertová","first_name":"Daniela","full_name":"Seifertová, Daniela"},{"first_name":"Ricardo","full_name":"Tejos, Ricardo","last_name":"Tejos"},{"last_name":"Meisel","full_name":"Meisel, Lee A","first_name":"Lee"},{"first_name":"Eva","full_name":"Zažímalová, Eva","last_name":"Zažímalová"},{"full_name":"Gadella, Theodorus W","first_name":"Theodorus","last_name":"Gadella"},{"last_name":"Stierhof","first_name":"York","full_name":"Stierhof, York-Dieter"},{"full_name":"Ueda, Takashi","first_name":"Takashi","last_name":"Ueda"},{"first_name":"Kazuhiro","full_name":"Oiwa, Kazuhiro","last_name":"Oiwa"},{"full_name":"Akhmanova, Anna","first_name":"Anna","last_name":"Akhmanova"},{"full_name":"Brock, Roland","first_name":"Roland","last_name":"Brock"},{"last_name":"Spang","first_name":"Anne","full_name":"Spang, Anne"},{"first_name":"Jirí","full_name":"Jirí Friml","orcid":"0000-0002-8302-7596","last_name":"Friml","id":"4159519E-F248-11E8-B48F-1D18A9856A87"}],"quality_controlled":0,"issue":"11","intvolume":"       105","month":"03","publication_status":"published","_id":"3031","status":"public","day":"18","publication":"PNAS","publisher":"National Academy of Sciences","date_updated":"2021-01-12T07:40:34Z","citation":{"apa":"Dhonukshe, P., Grigoriev, I., Fischer, R., Tominaga, M., Robinson, D., Hašek, J., … Friml, J. (2008). Auxin transport inhibitors impair vesicle motility and actin cytoskeleton dynamics in diverse eukaryotes. <i>PNAS</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.0711414105\">https://doi.org/10.1073/pnas.0711414105</a>","short":"P. Dhonukshe, I. Grigoriev, R. Fischer, M. Tominaga, D. Robinson, J. Hašek, T. Paciorek, J. Petrášek, D. Seifertová, R. Tejos, L. Meisel, E. Zažímalová, T. Gadella, Y. Stierhof, T. Ueda, K. Oiwa, A. Akhmanova, R. Brock, A. Spang, J. Friml, PNAS 105 (2008) 4489–4494.","mla":"Dhonukshe, Pankaj, et al. “Auxin Transport Inhibitors Impair Vesicle Motility and Actin Cytoskeleton Dynamics in Diverse Eukaryotes.” <i>PNAS</i>, vol. 105, no. 11, National Academy of Sciences, 2008, pp. 4489–94, doi:<a href=\"https://doi.org/10.1073/pnas.0711414105\">10.1073/pnas.0711414105</a>.","chicago":"Dhonukshe, Pankaj, Ilya Grigoriev, Rainer Fischer, Motoki Tominaga, David Robinson, Jiří Hašek, Tomasz Paciorek, et al. “Auxin Transport Inhibitors Impair Vesicle Motility and Actin Cytoskeleton Dynamics in Diverse Eukaryotes.” <i>PNAS</i>. National Academy of Sciences, 2008. <a href=\"https://doi.org/10.1073/pnas.0711414105\">https://doi.org/10.1073/pnas.0711414105</a>.","ama":"Dhonukshe P, Grigoriev I, Fischer R, et al. Auxin transport inhibitors impair vesicle motility and actin cytoskeleton dynamics in diverse eukaryotes. <i>PNAS</i>. 2008;105(11):4489-4494. doi:<a href=\"https://doi.org/10.1073/pnas.0711414105\">10.1073/pnas.0711414105</a>","ieee":"P. Dhonukshe <i>et al.</i>, “Auxin transport inhibitors impair vesicle motility and actin cytoskeleton dynamics in diverse eukaryotes,” <i>PNAS</i>, vol. 105, no. 11. National Academy of Sciences, pp. 4489–4494, 2008.","ista":"Dhonukshe P, Grigoriev I, Fischer R, Tominaga M, Robinson D, Hašek J, Paciorek T, Petrášek J, Seifertová D, Tejos R, Meisel L, Zažímalová E, Gadella T, Stierhof Y, Ueda T, Oiwa K, Akhmanova A, Brock R, Spang A, Friml J. 2008. Auxin transport inhibitors impair vesicle motility and actin cytoskeleton dynamics in diverse eukaryotes. PNAS. 105(11), 4489–4494."},"title":"Auxin transport inhibitors impair vesicle motility and actin cytoskeleton dynamics in diverse eukaryotes","year":"2008","doi":"10.1073/pnas.0711414105","extern":1,"date_published":"2008-03-18T00:00:00Z","volume":105,"publist_id":"3672","date_created":"2018-12-11T12:00:58Z","type":"journal_article"},{"doi":"10.1016/j.cub.2008.03.021","extern":1,"date_published":"2008-04-08T00:00:00Z","publist_id":"3670","volume":18,"date_created":"2018-12-11T12:00:58Z","type":"journal_article","day":"08","publication":"Current Biology","publisher":"Cell Press","date_updated":"2021-01-12T07:40:34Z","citation":{"ista":"Kleine Vehn J, Dhonukshe P, Sauer M, Brewer P, Wiśniewska J, Paciorek T, Benková E, Friml J. 2008. ARF GEF dependent transcytosis and polar delivery of PIN auxin carriers in Arabidopsis. Current Biology. 18(7), 526–531.","ieee":"J. Kleine Vehn <i>et al.</i>, “ARF GEF dependent transcytosis and polar delivery of PIN auxin carriers in Arabidopsis,” <i>Current Biology</i>, vol. 18, no. 7. Cell Press, pp. 526–531, 2008.","ama":"Kleine Vehn J, Dhonukshe P, Sauer M, et al. ARF GEF dependent transcytosis and polar delivery of PIN auxin carriers in Arabidopsis. <i>Current Biology</i>. 2008;18(7):526-531. doi:<a href=\"https://doi.org/10.1016/j.cub.2008.03.021\">10.1016/j.cub.2008.03.021</a>","chicago":"Kleine Vehn, Jürgen, Pankaj Dhonukshe, Michael Sauer, Philip Brewer, Justyna Wiśniewska, Tomasz Paciorek, Eva Benková, and Jiří Friml. “ARF GEF Dependent Transcytosis and Polar Delivery of PIN Auxin Carriers in Arabidopsis.” <i>Current Biology</i>. Cell Press, 2008. <a href=\"https://doi.org/10.1016/j.cub.2008.03.021\">https://doi.org/10.1016/j.cub.2008.03.021</a>.","apa":"Kleine Vehn, J., Dhonukshe, P., Sauer, M., Brewer, P., Wiśniewska, J., Paciorek, T., … Friml, J. (2008). ARF GEF dependent transcytosis and polar delivery of PIN auxin carriers in Arabidopsis. <i>Current Biology</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.cub.2008.03.021\">https://doi.org/10.1016/j.cub.2008.03.021</a>","short":"J. Kleine Vehn, P. Dhonukshe, M. Sauer, P. Brewer, J. Wiśniewska, T. Paciorek, E. Benková, J. Friml, Current Biology 18 (2008) 526–531.","mla":"Kleine Vehn, Jürgen, et al. “ARF GEF Dependent Transcytosis and Polar Delivery of PIN Auxin Carriers in Arabidopsis.” <i>Current Biology</i>, vol. 18, no. 7, Cell Press, 2008, pp. 526–31, doi:<a href=\"https://doi.org/10.1016/j.cub.2008.03.021\">10.1016/j.cub.2008.03.021</a>."},"title":"ARF GEF dependent transcytosis and polar delivery of PIN auxin carriers in Arabidopsis","year":"2008","issue":"7","publication_status":"published","month":"04","intvolume":"        18","_id":"3032","status":"public","abstract":[{"text":"\n\nCell polarity manifested by the polar cargo delivery to different plasma-membrane domains is a fundamental feature of multicellular organisms. Pathways for polar delivery have been identified in animals; prominent among them is transcytosis, which involves cargo movement between different sides of the cell [1]. PIN transporters are prominent polar cargoes in plants, whose polar subcellular localization determines the directional flow of the signaling molecule auxin [2, 3]. In this study, we address the cellular mechanisms of PIN polar targeting and dynamic polarity changes. We show that apical and basal PIN targeting pathways are interconnected but molecularly distinct by means of ARF GEF vesicle-trafficking regulators. Pharmacological or genetic interference with the Arabidopsis ARF GEF GNOM leads specifically to apicalization of basal cargoes such as PIN1. We visualize the translocation of PIN proteins between the opposite sides of polarized cells in vivo and show that this PIN transcytosis occurs by endocytic recycling and alternative recruitment of the same cargo molecules by apical and basal targeting machineries. Our data suggest that an ARF GEF-dependent transcytosis-like mechanism is operational in plants and provides a plausible mechanism to trigger changes in PIN polarity and hence auxin fluxes during embryogenesis and organogenesis.","lang":"eng"}],"page":"526 - 531","author":[{"last_name":"Kleine Vehn","full_name":"Kleine-Vehn, Jürgen","first_name":"Jürgen"},{"first_name":"Pankaj","full_name":"Dhonukshe, Pankaj","last_name":"Dhonukshe"},{"full_name":"Sauer, Michael","first_name":"Michael","last_name":"Sauer"},{"last_name":"Brewer","full_name":"Brewer, Philip B","first_name":"Philip"},{"full_name":"Wiśniewska, Justyna","first_name":"Justyna","last_name":"Wiśniewska"},{"last_name":"Paciorek","full_name":"Paciorek, Tomasz","first_name":"Tomasz"},{"orcid":"0000-0002-8510-9739","full_name":"Eva Benková","first_name":"Eva","id":"38F4F166-F248-11E8-B48F-1D18A9856A87","last_name":"Benková"},{"last_name":"Friml","id":"4159519E-F248-11E8-B48F-1D18A9856A87","first_name":"Jirí","full_name":"Jirí Friml","orcid":"0000-0002-8302-7596"}],"quality_controlled":0},{"day":"01","publisher":"Humana Press","publication":"Plant Embryogenesis","date_updated":"2021-01-12T07:40:35Z","citation":{"apa":"Sauer, M., &#38; Friml, J. (2008). Visualization of auxin gradients in embryogenesis . In M. Suárez &#38; P. Bozhkov (Eds.), <i>Plant Embryogenesis</i> (Vol. 427, pp. 137–144). Humana Press. <a href=\"https://doi.org/10.1007/978-1-59745-273-1_11\">https://doi.org/10.1007/978-1-59745-273-1_11</a>","mla":"Sauer, Michael, and Jiří Friml. “Visualization of Auxin Gradients in Embryogenesis .” <i>Plant Embryogenesis</i>, edited by María Suárez and Peter Bozhkov, vol. 427, Humana Press, 2008, pp. 137–44, doi:<a href=\"https://doi.org/10.1007/978-1-59745-273-1_11\">10.1007/978-1-59745-273-1_11</a>.","short":"M. Sauer, J. Friml, in:, M. Suárez, P. Bozhkov (Eds.), Plant Embryogenesis, Humana Press, 2008, pp. 137–144.","chicago":"Sauer, Michael, and Jiří Friml. “Visualization of Auxin Gradients in Embryogenesis .” In <i>Plant Embryogenesis</i>, edited by María Suárez and Peter Bozhkov, 427:137–44. Humana Press, 2008. <a href=\"https://doi.org/10.1007/978-1-59745-273-1_11\">https://doi.org/10.1007/978-1-59745-273-1_11</a>.","ieee":"M. Sauer and J. Friml, “Visualization of auxin gradients in embryogenesis ,” in <i>Plant Embryogenesis</i>, vol. 427, M. Suárez and P. Bozhkov, Eds. Humana Press, 2008, pp. 137–144.","ama":"Sauer M, Friml J. Visualization of auxin gradients in embryogenesis . In: Suárez M, Bozhkov P, eds. <i>Plant Embryogenesis</i>. Vol 427. Humana Press; 2008:137-144. doi:<a href=\"https://doi.org/10.1007/978-1-59745-273-1_11\">10.1007/978-1-59745-273-1_11</a>","ista":"Sauer M, Friml J. 2008.Visualization of auxin gradients in embryogenesis . In: Plant Embryogenesis. Methods In Molecular Biology, vol. 427, 137–144."},"year":"2008","title":"Visualization of auxin gradients in embryogenesis ","doi":"10.1007/978-1-59745-273-1_11","extern":1,"editor":[{"last_name":"Suárez","full_name":"Suárez, María F","first_name":"María"},{"full_name":"Bozhkov,  Peter V","first_name":"Peter","last_name":"Bozhkov"}],"date_published":"2008-01-01T00:00:00Z","volume":427,"publist_id":"3668","date_created":"2018-12-11T12:00:58Z","type":"book_chapter","abstract":[{"text":"\nEmbryogenesis in Arabidopsis thaliana depends on the proper establishment and maintenance of local auxin accumulation. In the course of elucidating the connections between developmental progress and auxin distribution, several techniques have been developed to investigate spatial and temporal distribution of auxin response or accumulation in Arabidopsis embryos. This chapter reviews and describes two independent methods, the detection of the activity of auxin responsive transgenes and immunolocalization of auxin itself.","lang":"eng"}],"alternative_title":["Methods In Molecular Biology"],"page":"137 - 144","author":[{"first_name":"Michael","full_name":"Sauer, Michael","last_name":"Sauer"},{"orcid":"0000-0002-8302-7596","full_name":"Jirí Friml","first_name":"Jirí","id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml"}],"quality_controlled":0,"intvolume":"       427","publication_status":"published","month":"01","_id":"3033","status":"public"},{"title":"Plant biology: In their neighbour's shadow","year":"2008","citation":{"chicago":"Friml, Jiří, and Michael Sauer. “Plant Biology: In Their Neighbour’s Shadow.” <i>Nature</i>. Nature Publishing Group, 2008. <a href=\"https://doi.org/10.1038/453298a\">https://doi.org/10.1038/453298a</a>.","apa":"Friml, J., &#38; Sauer, M. (2008). Plant biology: In their neighbour’s shadow. <i>Nature</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/453298a\">https://doi.org/10.1038/453298a</a>","mla":"Friml, Jiří, and Michael Sauer. “Plant Biology: In Their Neighbour’s Shadow.” <i>Nature</i>, vol. 453, no. 7193, Nature Publishing Group, 2008, pp. 298–99, doi:<a href=\"https://doi.org/10.1038/453298a\">10.1038/453298a</a>.","short":"J. Friml, M. Sauer, Nature 453 (2008) 298–299.","ista":"Friml J, Sauer M. 2008. Plant biology: In their neighbour’s shadow. Nature. 453(7193), 298–299.","ama":"Friml J, Sauer M. Plant biology: In their neighbour’s shadow. <i>Nature</i>. 2008;453(7193):298-299. doi:<a href=\"https://doi.org/10.1038/453298a\">10.1038/453298a</a>","ieee":"J. Friml and M. Sauer, “Plant biology: In their neighbour’s shadow,” <i>Nature</i>, vol. 453, no. 7193. Nature Publishing Group, pp. 298–299, 2008."},"date_updated":"2021-01-12T07:40:35Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"Nature Publishing Group","publication":"Nature","day":"15","type":"journal_article","date_created":"2018-12-11T12:00:59Z","publist_id":"3669","volume":453,"date_published":"2008-05-15T00:00:00Z","extern":"1","doi":"10.1038/453298a","quality_controlled":"1","author":[{"first_name":"Jirí","full_name":"Friml, Jirí","orcid":"0000-0002-8302-7596","last_name":"Friml","id":"4159519E-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Sauer","full_name":"Sauer, Michael","first_name":"Michael"}],"page":"298 - 299","abstract":[{"lang":"eng","text":"They can't move away from shade, so plants resort to a molecular solution to find a place in the sun. The action they take is quite radical, and involves a reprogramming of their development. "}],"status":"public","_id":"3034","oa_version":"None","publication_status":"published","month":"05","intvolume":"       453","language":[{"iso":"eng"}],"issue":"7193","article_type":"letter_note"},{"date_published":"2008-03-07T00:00:00Z","editor":[{"first_name":"María","full_name":"Suárez, María F","last_name":"Suárez"},{"full_name":"Bozhkov,  Peter V","first_name":"Peter","last_name":"Bozhkov"}],"extern":1,"doi":"10.1007/978-1-59745-273-1_5","type":"book_chapter","date_created":"2018-12-11T12:00:59Z","volume":427,"publist_id":"3667","publication":"Plant Embryogenesis","publisher":"Humana Press","day":"07","title":"In vitro culture of Arabidopsis embryos ","year":"2008","citation":{"chicago":"Sauer, Michael, and Jiří Friml. “In Vitro Culture of Arabidopsis Embryos .” In <i>Plant Embryogenesis</i>, edited by María Suárez and Peter Bozhkov, 427:71–76. Humana Press, 2008. <a href=\"https://doi.org/10.1007/978-1-59745-273-1_5\">https://doi.org/10.1007/978-1-59745-273-1_5</a>.","short":"M. Sauer, J. Friml, in:, M. Suárez, P. Bozhkov (Eds.), Plant Embryogenesis, Humana Press, 2008, pp. 71–76.","mla":"Sauer, Michael, and Jiří Friml. “In Vitro Culture of Arabidopsis Embryos .” <i>Plant Embryogenesis</i>, edited by María Suárez and Peter Bozhkov, vol. 427, Humana Press, 2008, pp. 71–76, doi:<a href=\"https://doi.org/10.1007/978-1-59745-273-1_5\">10.1007/978-1-59745-273-1_5</a>.","apa":"Sauer, M., &#38; Friml, J. (2008). In vitro culture of Arabidopsis embryos . In M. Suárez &#38; P. Bozhkov (Eds.), <i>Plant Embryogenesis</i> (Vol. 427, pp. 71–76). Humana Press. <a href=\"https://doi.org/10.1007/978-1-59745-273-1_5\">https://doi.org/10.1007/978-1-59745-273-1_5</a>","ista":"Sauer M, Friml J. 2008.In vitro culture of Arabidopsis embryos . In: Plant Embryogenesis. Methods In Molecular Biology, vol. 427, 71–76.","ama":"Sauer M, Friml J. In vitro culture of Arabidopsis embryos . In: Suárez M, Bozhkov P, eds. <i>Plant Embryogenesis</i>. Vol 427. Humana Press; 2008:71-76. doi:<a href=\"https://doi.org/10.1007/978-1-59745-273-1_5\">10.1007/978-1-59745-273-1_5</a>","ieee":"M. Sauer and J. Friml, “In vitro culture of Arabidopsis embryos ,” in <i>Plant Embryogenesis</i>, vol. 427, M. Suárez and P. Bozhkov, Eds. Humana Press, 2008, pp. 71–76."},"date_updated":"2021-01-12T07:40:35Z","status":"public","_id":"3035","month":"03","intvolume":"       427","publication_status":"published","alternative_title":["Methods In Molecular Biology"],"abstract":[{"lang":"eng","text":"Embryogenesis of Arabidopsis thaliana follows a nearly invariant cell division pattern and provides an ideal system for studies of early plant development. However, experimental manipulation with embryogenesis is difficult, as the embryo develops deeply inside maternal tissues. Here, we present a method to culture zygotic Arabidopsis embryos in vitro. It enables culturing for prolonged periods of time from the first developmental stages on. The technique omits excision of the embryo by culturing the entire ovule, which facilitates the manual procedure. It allows pharmacological manipulation of embryo development and does not interfere with standard techniques for localizing gene expression and protein localization in the cultivated embryos."}],"quality_controlled":0,"author":[{"first_name":"Michael","full_name":"Sauer, Michael","last_name":"Sauer"},{"id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml","full_name":"Jirí Friml","orcid":"0000-0002-8302-7596","first_name":"Jirí"}],"page":"71 - 76"},{"publication_status":"published","intvolume":"       105","month":"06","_id":"3036","status":"public","issue":"25","page":"8790 - 8794","author":[{"full_name":"Dubrovsky, Joseph G","first_name":"Joseph","last_name":"Dubrovsky"},{"last_name":"Sauer","full_name":"Sauer, Michael","first_name":"Michael"},{"last_name":"Napsucialy Mendivil","full_name":"Napsucialy-Mendivil, Selene","first_name":"Selene"},{"full_name":"Ivanchenko, Maria G","first_name":"Maria","last_name":"Ivanchenko"},{"last_name":"Friml","id":"4159519E-F248-11E8-B48F-1D18A9856A87","first_name":"Jirí","full_name":"Jirí Friml","orcid":"0000-0002-8302-7596"},{"full_name":"Shishkova, Svetlana","first_name":"Svetlana","last_name":"Shishkova"},{"first_name":"John","full_name":"Celenza, John","last_name":"Celenza"},{"first_name":"Eva","orcid":"0000-0002-8510-9739","full_name":"Eva Benková","last_name":"Benková","id":"38F4F166-F248-11E8-B48F-1D18A9856A87"}],"quality_controlled":0,"abstract":[{"text":"Plants exhibit an exceptional adaptability to different environmental conditions. To a large extent, this adaptability depends on their ability to initiate and form new organs throughout their entire postembryonic life. Plant shoot and root systems unceasingly branch and form axillary shoots or lateral roots, respectively. The first event in the formation of a new organ is specification of founder cells. Several plant hormones, prominent among them auxin, have been implicated in the acquisition of founder cell identity by differentiated cells, but the mechanisms underlying this process are largely elusive. Here, we show that auxin and its local accumulation in root pericycle cells is a necessary and sufficient signal to respecify these cells into lateral root founder cells. Analysis of the alf4-1 mutant suggests that specification of founder cells and the subsequent activation of cell division leading to primordium formation represent two genetically separable events. Time-lapse experiments show that the activation of an auxin response is the earliest detectable event in founder cell specification. Accordingly, local activation of auxin response correlates absolutely with the acquisition of founder cell identity and precedes the actual formation of a lateral root primordium through patterned cell division. Local production and subsequent accumulation of auxin in single pericycle cells induced by Cre-Lox-based activation of auxin synthesis converts them into founder cells. Thus, auxin is the local instructive signal that is sufficient for acquisition of founder cell identity and can be considered a morphogenetic trigger in postembryonic plant organogenesis.","lang":"eng"}],"publist_id":"3666","volume":105,"date_created":"2018-12-11T12:00:59Z","type":"journal_article","doi":"10.1073/pnas.0712307105","extern":1,"date_published":"2008-06-24T00:00:00Z","citation":{"chicago":"Dubrovsky, Joseph, Michael Sauer, Selene Napsucialy Mendivil, Maria Ivanchenko, Jiří Friml, Svetlana Shishkova, John Celenza, and Eva Benková. “Auxin Acts as a Local Morphogenetic Trigger to Specify Lateral Root Founder Cells.” <i>PNAS</i>. National Academy of Sciences, 2008. <a href=\"https://doi.org/10.1073/pnas.0712307105\">https://doi.org/10.1073/pnas.0712307105</a>.","mla":"Dubrovsky, Joseph, et al. “Auxin Acts as a Local Morphogenetic Trigger to Specify Lateral Root Founder Cells.” <i>PNAS</i>, vol. 105, no. 25, National Academy of Sciences, 2008, pp. 8790–94, doi:<a href=\"https://doi.org/10.1073/pnas.0712307105\">10.1073/pnas.0712307105</a>.","short":"J. Dubrovsky, M. Sauer, S. Napsucialy Mendivil, M. Ivanchenko, J. Friml, S. Shishkova, J. Celenza, E. Benková, PNAS 105 (2008) 8790–8794.","apa":"Dubrovsky, J., Sauer, M., Napsucialy Mendivil, S., Ivanchenko, M., Friml, J., Shishkova, S., … Benková, E. (2008). Auxin acts as a local morphogenetic trigger to specify lateral root founder cells. <i>PNAS</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.0712307105\">https://doi.org/10.1073/pnas.0712307105</a>","ista":"Dubrovsky J, Sauer M, Napsucialy Mendivil S, Ivanchenko M, Friml J, Shishkova S, Celenza J, Benková E. 2008. Auxin acts as a local morphogenetic trigger to specify lateral root founder cells. PNAS. 105(25), 8790–8794.","ieee":"J. Dubrovsky <i>et al.</i>, “Auxin acts as a local morphogenetic trigger to specify lateral root founder cells,” <i>PNAS</i>, vol. 105, no. 25. National Academy of Sciences, pp. 8790–8794, 2008.","ama":"Dubrovsky J, Sauer M, Napsucialy Mendivil S, et al. Auxin acts as a local morphogenetic trigger to specify lateral root founder cells. <i>PNAS</i>. 2008;105(25):8790-8794. doi:<a href=\"https://doi.org/10.1073/pnas.0712307105\">10.1073/pnas.0712307105</a>"},"date_updated":"2021-01-12T07:40:36Z","year":"2008","title":"Auxin acts as a local morphogenetic trigger to specify lateral root founder cells","day":"24","publisher":"National Academy of Sciences","publication":"PNAS"},{"main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2492634/","open_access":"1"}],"publication":"Plant Physiology","publisher":"American Society of Plant Biologists","day":"04","oa":1,"title":"PIN polar targeting","year":"2008","citation":{"mla":"Feraru, Elena, and Jiří Friml. “PIN Polar Targeting.” <i>Plant Physiology</i>, vol. 147, no. 4, American Society of Plant Biologists, 2008, pp. 1553–59, doi:<a href=\"https://doi.org/10.1104/pp.108.121756\">10.1104/pp.108.121756</a>.","short":"E. Feraru, J. Friml, Plant Physiology 147 (2008) 1553–1559.","apa":"Feraru, E., &#38; Friml, J. (2008). PIN polar targeting. <i>Plant Physiology</i>. American Society of Plant Biologists. <a href=\"https://doi.org/10.1104/pp.108.121756\">https://doi.org/10.1104/pp.108.121756</a>","chicago":"Feraru, Elena, and Jiří Friml. “PIN Polar Targeting.” <i>Plant Physiology</i>. American Society of Plant Biologists, 2008. <a href=\"https://doi.org/10.1104/pp.108.121756\">https://doi.org/10.1104/pp.108.121756</a>.","ieee":"E. Feraru and J. Friml, “PIN polar targeting,” <i>Plant Physiology</i>, vol. 147, no. 4. American Society of Plant Biologists, pp. 1553–1559, 2008.","ama":"Feraru E, Friml J. PIN polar targeting. <i>Plant Physiology</i>. 2008;147(4):1553-1559. doi:<a href=\"https://doi.org/10.1104/pp.108.121756\">10.1104/pp.108.121756</a>","ista":"Feraru E, Friml J. 2008. PIN polar targeting. Plant Physiology. 147(4), 1553–1559."},"date_updated":"2021-01-12T07:40:36Z","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","date_published":"2008-08-04T00:00:00Z","doi":"10.1104/pp.108.121756","extern":"1","date_created":"2018-12-11T12:01:00Z","type":"journal_article","publist_id":"3664","volume":147,"quality_controlled":"1","pmid":1,"page":"1553 - 1559","author":[{"last_name":"Feraru","first_name":"Elena","full_name":"Feraru, Elena"},{"orcid":"0000-0002-8302-7596","full_name":"Friml, Jirí","first_name":"Jirí","id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml"}],"issue":"4","_id":"3037","oa_version":"Published Version","status":"public","language":[{"iso":"eng"}],"external_id":{"pmid":["18678746"]},"publication_status":"published","intvolume":"       147","month":"08"},{"publist_id":"3665","volume":10,"date_created":"2018-12-11T12:01:00Z","type":"journal_article","doi":"10.1038/ncb1754","extern":1,"date_published":"2008-07-11T00:00:00Z","date_updated":"2021-01-12T07:40:37Z","citation":{"apa":"Swarup, K., Benková, E., Swarup, R., Casimiro, I., Péret, B., Yang, Y., … Bennett, M. (2008). The auxin influx carrier LAX3 promotes lateral root emergence. <i>Nature Cell Biology</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/ncb1754\">https://doi.org/10.1038/ncb1754</a>","mla":"Swarup, Kamal, et al. “The Auxin Influx Carrier LAX3 Promotes Lateral Root Emergence.” <i>Nature Cell Biology</i>, vol. 10, no. 8, Nature Publishing Group, 2008, pp. 946–54, doi:<a href=\"https://doi.org/10.1038/ncb1754\">10.1038/ncb1754</a>.","short":"K. Swarup, E. Benková, R. Swarup, I. Casimiro, B. Péret, Y. Yang, G. Parry, E. Nielsen, I. De Smet, S. Vanneste, M. Levesque, D. Carrier, N. James, V. Calvo, K. Ljung, E. Kramer, R. Roberts, N. Graham, S. Marillonnet, K. Patel, J. Jones, C. Taylor, D. Schachtman, S. May, G. Sandberg, P. Benfey, J. Friml, I. Kerr, T. Beeckman, L. Laplaze, M. Bennett, Nature Cell Biology 10 (2008) 946–954.","chicago":"Swarup, Kamal, Eva Benková, Ranjan Swarup, Ilda Casimiro, Benjamin Péret, Yaodong Yang, Geraint Parry, et al. “The Auxin Influx Carrier LAX3 Promotes Lateral Root Emergence.” <i>Nature Cell Biology</i>. Nature Publishing Group, 2008. <a href=\"https://doi.org/10.1038/ncb1754\">https://doi.org/10.1038/ncb1754</a>.","ieee":"K. Swarup <i>et al.</i>, “The auxin influx carrier LAX3 promotes lateral root emergence,” <i>Nature Cell Biology</i>, vol. 10, no. 8. Nature Publishing Group, pp. 946–954, 2008.","ama":"Swarup K, Benková E, Swarup R, et al. The auxin influx carrier LAX3 promotes lateral root emergence. <i>Nature Cell Biology</i>. 2008;10(8):946-954. doi:<a href=\"https://doi.org/10.1038/ncb1754\">10.1038/ncb1754</a>","ista":"Swarup K, Benková E, Swarup R, Casimiro I, Péret B, Yang Y, Parry G, Nielsen E, De Smet I, Vanneste S, Levesque M, Carrier D, James N, Calvo V, Ljung K, Kramer E, Roberts R, Graham N, Marillonnet S, Patel K, Jones J, Taylor C, Schachtman D, May S, Sandberg G, Benfey P, Friml J, Kerr I, Beeckman T, Laplaze L, Bennett M. 2008. The auxin influx carrier LAX3 promotes lateral root emergence. Nature Cell Biology. 10(8), 946–954."},"year":"2008","title":"The auxin influx carrier LAX3 promotes lateral root emergence","day":"11","publisher":"Nature Publishing Group","publication":"Nature Cell Biology","month":"07","publication_status":"published","intvolume":"        10","_id":"3038","status":"public","issue":"8","page":"946 - 954","author":[{"full_name":"Swarup, Kamal","first_name":"Kamal","last_name":"Swarup"},{"first_name":"Eva","full_name":"Eva Benková","orcid":"0000-0002-8510-9739","last_name":"Benková","id":"38F4F166-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Swarup","full_name":"Swarup, Ranjan","first_name":"Ranjan"},{"last_name":"Casimiro","full_name":"Casimiro, Ilda","first_name":"Ilda"},{"full_name":"Péret, Benjamin","first_name":"Benjamin","last_name":"Péret"},{"first_name":"Yaodong","full_name":"Yang, Yaodong","last_name":"Yang"},{"full_name":"Parry, Geraint","first_name":"Geraint","last_name":"Parry"},{"full_name":"Nielsen, Erik","first_name":"Erik","last_name":"Nielsen"},{"full_name":"De Smet, Ive","first_name":"Ive","last_name":"De Smet"},{"full_name":"Vanneste, Steffen","first_name":"Steffen","last_name":"Vanneste"},{"last_name":"Levesque","first_name":"Mitchell","full_name":"Levesque, Mitchell P"},{"full_name":"Carrier, David","first_name":"David","last_name":"Carrier"},{"full_name":"James, Nicholas","first_name":"Nicholas","last_name":"James"},{"last_name":"Calvo","first_name":"Vanessa","full_name":"Calvo, Vanessa"},{"full_name":"Ljung, Karin","first_name":"Karin","last_name":"Ljung"},{"first_name":"Eric","full_name":"Kramer, Eric","last_name":"Kramer"},{"full_name":"Roberts, Rebecca","first_name":"Rebecca","last_name":"Roberts"},{"full_name":"Graham, Neil","first_name":"Neil","last_name":"Graham"},{"first_name":"Sylvestre","full_name":"Marillonnet, Sylvestre","last_name":"Marillonnet"},{"last_name":"Patel","full_name":"Patel, Kanu","first_name":"Kanu"},{"first_name":"Jonathan","full_name":"Jones, Jonathan D","last_name":"Jones"},{"first_name":"Christopher","full_name":"Taylor, Christopher G","last_name":"Taylor"},{"first_name":"Daniel","full_name":"Schachtman, Daniel P","last_name":"Schachtman"},{"last_name":"May","full_name":"May, Sean","first_name":"Sean"},{"last_name":"Sandberg","first_name":"Göran","full_name":"Sandberg, Göran"},{"full_name":"Benfey, Philip N","first_name":"Philip","last_name":"Benfey"},{"first_name":"Jirí","full_name":"Jirí Friml","orcid":"0000-0002-8302-7596","last_name":"Friml","id":"4159519E-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Kerr","full_name":"Kerr, Ian","first_name":"Ian"},{"full_name":"Beeckman, Tom","first_name":"Tom","last_name":"Beeckman"},{"last_name":"Laplaze","full_name":"Laplaze, Laurent","first_name":"Laurent"},{"first_name":"Malcolm","full_name":"Bennett, Malcolm J","last_name":"Bennett"}],"quality_controlled":0,"abstract":[{"lang":"eng","text":"Lateral roots originate deep within the parental root from a small number of founder cells at the periphery of vascular tissues and must emerge through intervening layers of tissues. We describe how the hormone auxin, which originates from the developing lateral root, acts as a local inductive signal which re-programmes adjacent cells. Auxin induces the expression of a previously uncharacterized auxin influx carrier LAX3 in cortical and epidermal cells directly overlaying new primordia. Increased LAX3 activity reinforces the auxin-dependent induction of a selection of cell-wall-remodelling enzymes, which are likely to promote cell separation in advance of developing lateral root primordia."}]},{"quality_controlled":0,"author":[{"first_name":"Ive","full_name":"De Smet, Ive","last_name":"De Smet"},{"last_name":"Vassileva","first_name":"Valya","full_name":"Vassileva, Valya"},{"last_name":"De Rybel","first_name":"Bert","full_name":"De Rybel, Bert"},{"last_name":"Levesque","first_name":"Mitchell","full_name":"Levesque, Mitchell P"},{"last_name":"Grunewald","first_name":"Wim","full_name":"Grunewald, Wim"},{"last_name":"Van Damme","first_name":"Daniël","full_name":"Van Damme, Daniël"},{"last_name":"Van Noorden","full_name":"Van Noorden, Giel","first_name":"Giel"},{"last_name":"Naudts","first_name":"Mirande","full_name":"Naudts, Mirande"},{"last_name":"Van Isterdael","first_name":"Gert","full_name":"Van Isterdael, Gert"},{"full_name":"De Clercq, Rebecca","first_name":"Rebecca","last_name":"De Clercq"},{"first_name":"Jean","full_name":"Wang, Jean Y","last_name":"Wang"},{"last_name":"Meuli","full_name":"Meuli, Nicholas","first_name":"Nicholas"},{"last_name":"Vanneste","full_name":"Vanneste, Steffen","first_name":"Steffen"},{"full_name":"Jirí Friml","orcid":"0000-0002-8302-7596","first_name":"Jirí","id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml"},{"last_name":"Hilson","first_name":"Pierre","full_name":"Hilson, Pierre"},{"full_name":"Jürgens, Gerd","first_name":"Gerd","last_name":"Jürgens"},{"last_name":"Ingram","full_name":"Ingram, Gwyneth C","first_name":"Gwyneth"},{"first_name":"Dirk","full_name":"Inzé, Dirk","last_name":"Inzé"},{"last_name":"Benfey","first_name":"Philip","full_name":"Benfey, Philip N"},{"last_name":"Beeckman","first_name":"Tom","full_name":"Beeckman, Tom"}],"page":"594 - 597","abstract":[{"text":"During the development of multicellular organisms, organogenesis and pattern formation depend on formative divisions to specify and maintain pools of stem cells. In higher plants, these activities are essential to shape the final root architecture because the functioning of root apical meristems and the de novo formation of lateral roots entirely rely on it. We used transcript profiling on sorted pericycle cells undergoing lateral root initiation to identify the receptor-like kinase ACR4 of Arabidopsis as a key factor both in promoting formative cell divisions in the pericycle and in constraining the number of these divisions once organogenesis has been started. In the root tip meristem, ACR4 shows a similar action by controlling cell proliferation activity in the columella cell lineage. Thus, ACR4 function reveals a common mechanism of formative cell division control in the main root tip meristem and during lateral root initiation.","lang":"eng"}],"status":"public","_id":"3039","intvolume":"       322","publication_status":"published","month":"10","issue":"5901","year":"2008","title":"Receptor-like kinase ACR4 restricts formative cell divisions in the Arabidopsis root","date_updated":"2021-01-12T07:40:37Z","citation":{"ista":"De Smet I, Vassileva V, De Rybel B, Levesque M, Grunewald W, Van Damme D, Van Noorden G, Naudts M, Van Isterdael G, De Clercq R, Wang J, Meuli N, Vanneste S, Friml J, Hilson P, Jürgens G, Ingram G, Inzé D, Benfey P, Beeckman T. 2008. Receptor-like kinase ACR4 restricts formative cell divisions in the Arabidopsis root. Science. 322(5901), 594–597.","ama":"De Smet I, Vassileva V, De Rybel B, et al. Receptor-like kinase ACR4 restricts formative cell divisions in the Arabidopsis root. <i>Science</i>. 2008;322(5901):594-597. doi:<a href=\"https://doi.org/10.1126/science.1160158\">10.1126/science.1160158</a>","ieee":"I. De Smet <i>et al.</i>, “Receptor-like kinase ACR4 restricts formative cell divisions in the Arabidopsis root,” <i>Science</i>, vol. 322, no. 5901. American Association for the Advancement of Science, pp. 594–597, 2008.","chicago":"De Smet, Ive, Valya Vassileva, Bert De Rybel, Mitchell Levesque, Wim Grunewald, Daniël Van Damme, Giel Van Noorden, et al. “Receptor-like Kinase ACR4 Restricts Formative Cell Divisions in the Arabidopsis Root.” <i>Science</i>. American Association for the Advancement of Science, 2008. <a href=\"https://doi.org/10.1126/science.1160158\">https://doi.org/10.1126/science.1160158</a>.","apa":"De Smet, I., Vassileva, V., De Rybel, B., Levesque, M., Grunewald, W., Van Damme, D., … Beeckman, T. (2008). Receptor-like kinase ACR4 restricts formative cell divisions in the Arabidopsis root. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1160158\">https://doi.org/10.1126/science.1160158</a>","mla":"De Smet, Ive, et al. “Receptor-like Kinase ACR4 Restricts Formative Cell Divisions in the Arabidopsis Root.” <i>Science</i>, vol. 322, no. 5901, American Association for the Advancement of Science, 2008, pp. 594–97, doi:<a href=\"https://doi.org/10.1126/science.1160158\">10.1126/science.1160158</a>.","short":"I. De Smet, V. Vassileva, B. De Rybel, M. Levesque, W. Grunewald, D. Van Damme, G. Van Noorden, M. Naudts, G. Van Isterdael, R. De Clercq, J. Wang, N. Meuli, S. Vanneste, J. Friml, P. Hilson, G. Jürgens, G. Ingram, D. Inzé, P. Benfey, T. Beeckman, Science 322 (2008) 594–597."},"publication":"Science","publisher":"American Association for the Advancement of Science","day":"24","type":"journal_article","date_created":"2018-12-11T12:01:00Z","volume":322,"publist_id":"3663","date_published":"2008-10-24T00:00:00Z","extern":1,"doi":"10.1126/science.1160158"},{"date_updated":"2021-01-12T07:40:38Z","citation":{"ieee":"J. Kleine Vehn, Ł. Łangowski, J. Wiśniewska, P. Dhonukshe, P. Brewer, and J. Friml, “Cellular and molecular requirements for polar PIN targeting and transcytosis in plants,” <i>Molecular Plant</i>, vol. 1, no. 6. Oxford University Press, pp. 1056–1066, 2008.","ama":"Kleine Vehn J, Łangowski Ł, Wiśniewska J, Dhonukshe P, Brewer P, Friml J. Cellular and molecular requirements for polar PIN targeting and transcytosis in plants. <i>Molecular Plant</i>. 2008;1(6):1056-1066. doi:<a href=\"https://doi.org/10.1093/mp/ssn062\">10.1093/mp/ssn062</a>","ista":"Kleine Vehn J, Łangowski Ł, Wiśniewska J, Dhonukshe P, Brewer P, Friml J. 2008. Cellular and molecular requirements for polar PIN targeting and transcytosis in plants. Molecular Plant. 1(6), 1056–1066.","apa":"Kleine Vehn, J., Łangowski, Ł., Wiśniewska, J., Dhonukshe, P., Brewer, P., &#38; Friml, J. (2008). Cellular and molecular requirements for polar PIN targeting and transcytosis in plants. <i>Molecular Plant</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/mp/ssn062\">https://doi.org/10.1093/mp/ssn062</a>","mla":"Kleine Vehn, Jürgen, et al. “Cellular and Molecular Requirements for Polar PIN Targeting and Transcytosis in Plants.” <i>Molecular Plant</i>, vol. 1, no. 6, Oxford University Press, 2008, pp. 1056–66, doi:<a href=\"https://doi.org/10.1093/mp/ssn062\">10.1093/mp/ssn062</a>.","short":"J. Kleine Vehn, Ł. Łangowski, J. Wiśniewska, P. Dhonukshe, P. Brewer, J. Friml, Molecular Plant 1 (2008) 1056–1066.","chicago":"Kleine Vehn, Jürgen, Łukasz Łangowski, Justyna Wiśniewska, Pankaj Dhonukshe, Philip Brewer, and Jiří Friml. “Cellular and Molecular Requirements for Polar PIN Targeting and Transcytosis in Plants.” <i>Molecular Plant</i>. Oxford University Press, 2008. <a href=\"https://doi.org/10.1093/mp/ssn062\">https://doi.org/10.1093/mp/ssn062</a>."},"year":"2008","title":"Cellular and molecular requirements for polar PIN targeting and transcytosis in plants","day":"01","publisher":"Oxford University Press","publication":"Molecular Plant","publist_id":"3662","volume":1,"date_created":"2018-12-11T12:01:01Z","type":"journal_article","doi":"10.1093/mp/ssn062","extern":1,"date_published":"2008-01-01T00:00:00Z","page":"1056 - 1066","author":[{"first_name":"Jürgen","full_name":"Kleine-Vehn, Jürgen","last_name":"Kleine Vehn"},{"first_name":"Łukasz","full_name":"Łangowski, Łukasz","last_name":"Łangowski"},{"last_name":"Wiśniewska","full_name":"Wiśniewska, Justyna","first_name":"Justyna"},{"last_name":"Dhonukshe","full_name":"Dhonukshe, Pankaj","first_name":"Pankaj"},{"last_name":"Brewer","full_name":"Brewer, Philip B","first_name":"Philip"},{"id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml","full_name":"Jirí Friml","orcid":"0000-0002-8302-7596","first_name":"Jirí"}],"quality_controlled":0,"abstract":[{"text":"The polar, sub-cellular localization of PIN auxin efflux carriers determines the direction of intercellular auxin flow, thus defining the spatial aspect of auxin signalling. Dynamic, transcytosis-like relocalizations of PIN proteins occur in response to external and internal signals, integrating these signals into changes in auxin distribution. Here, we examine the cellular and molecular mechanisms of polar PIN delivery and transcytosis. The mechanisms of the ARF-GEF-dependent polar targeting and transcytosis are well conserved and show little variations among diverse Arabidopsis ecotypes consistent with their fundamental importance in regulating plant development. At the cellular level, we refine previous findings on the role of the actin cytoskeleton in apical and basal PIN targeting, and identify a previously unknown role for microtubules, specifically in basal targeting. PIN protein delivery to different sides of the cell is mediated by ARF-dependent trafficking with a previously unknown complex level of distinct ARF-GEF vesicle trafficking regulators. Our data suggest that alternative recruitment of PIN proteins by these distinct pathways can account for cell type- and cargo-specific aspects of polar targeting, as well as for polarity changes in response to different signals. The resulting dynamic PIN positioning to different sides of cells defines a three-dimensional pattern of auxin fluxes within plant tissues.","lang":"eng"}],"month":"01","intvolume":"         1","publication_status":"published","_id":"3040","status":"public","issue":"6"},{"publist_id":"3661","volume":283,"type":"journal_article","date_created":"2018-12-11T12:01:01Z","extern":1,"doi":" 10.1074/jbc.M710122200","date_published":"2008-11-07T00:00:00Z","date_updated":"2021-01-12T07:40:38Z","citation":{"chicago":"Santelia, Diana, Sina Henrichs, Vincent Vincenzetti, Michael Sauer, Laurent Bigler, Markus Klein, Aurélien Bailly, et al. “Flavonoids Redirect PIN Mediated Polar Auxin Fluxes during Root Gravitropic Responses.” <i>Journal of Biological Chemistry</i>. American Society for Biochemistry and Molecular Biology, 2008. <a href=\"https://doi.org/ 10.1074/jbc.M710122200\">https://doi.org/ 10.1074/jbc.M710122200</a>.","mla":"Santelia, Diana, et al. “Flavonoids Redirect PIN Mediated Polar Auxin Fluxes during Root Gravitropic Responses.” <i>Journal of Biological Chemistry</i>, vol. 283, no. 45, American Society for Biochemistry and Molecular Biology, 2008, pp. 31218–26, doi:<a href=\"https://doi.org/ 10.1074/jbc.M710122200\"> 10.1074/jbc.M710122200</a>.","short":"D. Santelia, S. Henrichs, V. Vincenzetti, M. Sauer, L. Bigler, M. Klein, A. Bailly, Y. Lee, J. Friml, M. Geisler, E. Martinoia, Journal of Biological Chemistry 283 (2008) 31218–31226.","apa":"Santelia, D., Henrichs, S., Vincenzetti, V., Sauer, M., Bigler, L., Klein, M., … Martinoia, E. (2008). Flavonoids redirect PIN mediated polar auxin fluxes during root gravitropic responses. <i>Journal of Biological Chemistry</i>. American Society for Biochemistry and Molecular Biology. <a href=\"https://doi.org/ 10.1074/jbc.M710122200\">https://doi.org/ 10.1074/jbc.M710122200</a>","ista":"Santelia D, Henrichs S, Vincenzetti V, Sauer M, Bigler L, Klein M, Bailly A, Lee Y, Friml J, Geisler M, Martinoia E. 2008. Flavonoids redirect PIN mediated polar auxin fluxes during root gravitropic responses. Journal of Biological Chemistry. 283(45), 31218–31226.","ama":"Santelia D, Henrichs S, Vincenzetti V, et al. Flavonoids redirect PIN mediated polar auxin fluxes during root gravitropic responses. <i>Journal of Biological Chemistry</i>. 2008;283(45):31218-31226. doi:<a href=\"https://doi.org/ 10.1074/jbc.M710122200\"> 10.1074/jbc.M710122200</a>","ieee":"D. Santelia <i>et al.</i>, “Flavonoids redirect PIN mediated polar auxin fluxes during root gravitropic responses,” <i>Journal of Biological Chemistry</i>, vol. 283, no. 45. American Society for Biochemistry and Molecular Biology, pp. 31218–31226, 2008."},"title":"Flavonoids redirect PIN mediated polar auxin fluxes during root gravitropic responses","year":"2008","day":"07","publication":"Journal of Biological Chemistry","publisher":"American Society for Biochemistry and Molecular Biology","month":"11","publication_status":"published","intvolume":"       283","status":"public","_id":"3041","issue":"45","author":[{"full_name":"Santelia, Diana","first_name":"Diana","last_name":"Santelia"},{"last_name":"Henrichs","first_name":"Sina","full_name":"Henrichs, Sina"},{"last_name":"Vincenzetti","full_name":"Vincenzetti, Vincent","first_name":"Vincent"},{"first_name":"Michael","full_name":"Sauer, Michael","last_name":"Sauer"},{"last_name":"Bigler","first_name":"Laurent","full_name":"Bigler, Laurent"},{"full_name":"Klein, Markus B","first_name":"Markus","last_name":"Klein"},{"last_name":"Bailly","first_name":"Aurélien","full_name":"Bailly, Aurélien"},{"last_name":"Lee","first_name":"Yuree","full_name":"Lee, Yuree"},{"id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml","full_name":"Jirí Friml","orcid":"0000-0002-8302-7596","first_name":"Jirí"},{"last_name":"Geisler","first_name":"Markus","full_name":"Geisler, Markus"},{"full_name":"Martinoia, Enrico","first_name":"Enrico","last_name":"Martinoia"}],"page":"31218 - 31226","quality_controlled":0,"abstract":[{"text":"The rate, polarity, and symmetry of the flow of the plant hormone auxin are determined by the polar cellular localization of PIN-FORMED (PIN) auxin efflux carriers. Flavonoids, a class of secondary plant metabolites, have been suspected to modulate auxin transport and tropic responses. Nevertheless, the identity of specific flavonoid compounds involved and their molecular function and targets in vivo are essentially unknown. Here we show that the root elongation zone of agravitropic pin2/eir1/wav6/agr1 has an altered pattern and amount of flavonol glycosides. Application of nanomolar concentrations of flavonols to pin2 roots is sufficient to partially restore root gravitropism. By employing a quantitative cell biological approach, we demonstrate that flavonoids partially restore the formation of lateral auxin gradients in the absence of PIN2. Chemical complementation by flavonoids correlates with an asymmetric distribution of the PIN1 protein. pin2 complementation probably does not result from inhibition of auxin efflux, as supply of the auxin transport inhibitor N-1-naphthylphthalamic acid failed to restore pin2 gravitropism. We propose that flavonoids promote asymmetric PIN shifts during gravity stimulation, thus redirecting basipetal auxin streams necessary for root bending. © 2008 by The American Society for Biochemistry and Molecular Biology, Inc.","lang":"eng"}]},{"issue":"46","_id":"3042","status":"public","publication_status":"published","month":"11","intvolume":"       105","abstract":[{"lang":"eng","text":"All eukaryotic cells present at the cell surface a specific set of plasma membrane proteins that modulate responses to internal and external cues and whose activity is also regulated by protein degradation. We characterized the lytic vacuole-dependent degradation of membrane proteins in Arabidopsis thaliana by means of in vivo visualization of vacuolar targeting combined with quantitative protein analysis. We show that the vacuolar targeting pathway is used by multiple cargos including PIN-FORMED (PIN) efflux carriers for the phytohormone auxin. In vivo visualization of PIN2 vacuolar targeting revealed its differential degradation in response to environmental signals, such as gravity. In contrast to polar PIN delivery to the basal plasma membrane, which depends on the vesicle trafficking regulator ARF-GEF GNOM, PIN sorting to the lytic vacuolar pathway requires additional brefeldin A-sensitive ARF-GEF activity. Furthermore, we identified putative retromer components SORTING NEXIN1 (SNX1) and VACUOLAR PROTEIN SORTING29 (VPS29) as important factors in this pathway and propose that the retromer complex acts to retrieve PIN proteins from a late/pre-vacuolar compartment back to the recycling pathways. Our data suggest that ARF GEF- and retromer-dependent processes regulate PIN sorting to the vacuole in an antagonistic manner and illustrate instrumentalization of this mechanism for fine-tuning the auxin fluxes during gravitropic response."}],"quality_controlled":0,"page":"17812 - 17817","author":[{"full_name":"Kleine-Vehn, Jürgen","first_name":"Jürgen","last_name":"Kleine Vehn"},{"full_name":"Leitner, Johannes","first_name":"Johannes","last_name":"Leitner"},{"last_name":"Zwiewka","first_name":"Marta","full_name":"Zwiewka, Marta"},{"first_name":"Michael","full_name":"Sauer, Michael","last_name":"Sauer"},{"last_name":"Abas","full_name":"Abas, Lindy","first_name":"Lindy"},{"first_name":"Christian","full_name":"Luschnig, Christian","last_name":"Luschnig"},{"first_name":"Jirí","orcid":"0000-0002-8302-7596","full_name":"Jirí Friml","last_name":"Friml","id":"4159519E-F248-11E8-B48F-1D18A9856A87"}],"date_published":"2008-11-18T00:00:00Z","doi":"10.1073/pnas.0808073105","extern":1,"date_created":"2018-12-11T12:01:01Z","type":"journal_article","publist_id":"3659","volume":105,"publisher":"National Academy of Sciences","publication":"PNAS","day":"18","year":"2008","title":"Differential degradation of PIN2 auxin efflux carrier by retromer dependent vacuolar targeting","date_updated":"2021-01-12T07:40:39Z","citation":{"ieee":"J. Kleine Vehn <i>et al.</i>, “Differential degradation of PIN2 auxin efflux carrier by retromer dependent vacuolar targeting,” <i>PNAS</i>, vol. 105, no. 46. National Academy of Sciences, pp. 17812–17817, 2008.","ama":"Kleine Vehn J, Leitner J, Zwiewka M, et al. Differential degradation of PIN2 auxin efflux carrier by retromer dependent vacuolar targeting. <i>PNAS</i>. 2008;105(46):17812-17817. doi:<a href=\"https://doi.org/10.1073/pnas.0808073105\">10.1073/pnas.0808073105</a>","ista":"Kleine Vehn J, Leitner J, Zwiewka M, Sauer M, Abas L, Luschnig C, Friml J. 2008. Differential degradation of PIN2 auxin efflux carrier by retromer dependent vacuolar targeting. PNAS. 105(46), 17812–17817.","mla":"Kleine Vehn, Jürgen, et al. “Differential Degradation of PIN2 Auxin Efflux Carrier by Retromer Dependent Vacuolar Targeting.” <i>PNAS</i>, vol. 105, no. 46, National Academy of Sciences, 2008, pp. 17812–17, doi:<a href=\"https://doi.org/10.1073/pnas.0808073105\">10.1073/pnas.0808073105</a>.","short":"J. Kleine Vehn, J. Leitner, M. Zwiewka, M. Sauer, L. Abas, C. Luschnig, J. Friml, PNAS 105 (2008) 17812–17817.","apa":"Kleine Vehn, J., Leitner, J., Zwiewka, M., Sauer, M., Abas, L., Luschnig, C., &#38; Friml, J. (2008). Differential degradation of PIN2 auxin efflux carrier by retromer dependent vacuolar targeting. <i>PNAS</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.0808073105\">https://doi.org/10.1073/pnas.0808073105</a>","chicago":"Kleine Vehn, Jürgen, Johannes Leitner, Marta Zwiewka, Michael Sauer, Lindy Abas, Christian Luschnig, and Jiří Friml. “Differential Degradation of PIN2 Auxin Efflux Carrier by Retromer Dependent Vacuolar Targeting.” <i>PNAS</i>. National Academy of Sciences, 2008. <a href=\"https://doi.org/10.1073/pnas.0808073105\">https://doi.org/10.1073/pnas.0808073105</a>."}},{"date_published":"2008-11-10T00:00:00Z","doi":"10.1146/annurev.cellbio.24.110707.175254","extern":"1","date_created":"2018-12-11T12:01:02Z","type":"journal_article","publist_id":"3660","volume":24,"publication":"Annual Review of Cell and Developmental Biology","publisher":"Annual Reviews","day":"10","title":"Polar targeting and endocytic recycling in auxin-dependent plant development","year":"2008","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","citation":{"chicago":"Kleine Vehn, Jürgen, and Jiří Friml. “Polar Targeting and Endocytic Recycling in Auxin-Dependent Plant Development.” <i>Annual Review of Cell and Developmental Biology</i>. Annual Reviews, 2008. <a href=\"https://doi.org/10.1146/annurev.cellbio.24.110707.175254\">https://doi.org/10.1146/annurev.cellbio.24.110707.175254</a>.","apa":"Kleine Vehn, J., &#38; Friml, J. (2008). Polar targeting and endocytic recycling in auxin-dependent plant development. <i>Annual Review of Cell and Developmental Biology</i>. Annual Reviews. <a href=\"https://doi.org/10.1146/annurev.cellbio.24.110707.175254\">https://doi.org/10.1146/annurev.cellbio.24.110707.175254</a>","mla":"Kleine Vehn, Jürgen, and Jiří Friml. “Polar Targeting and Endocytic Recycling in Auxin-Dependent Plant Development.” <i>Annual Review of Cell and Developmental Biology</i>, vol. 24, Annual Reviews, 2008, pp. 447–73, doi:<a href=\"https://doi.org/10.1146/annurev.cellbio.24.110707.175254\">10.1146/annurev.cellbio.24.110707.175254</a>.","short":"J. Kleine Vehn, J. Friml, Annual Review of Cell and Developmental Biology 24 (2008) 447–473.","ista":"Kleine Vehn J, Friml J. 2008. Polar targeting and endocytic recycling in auxin-dependent plant development. Annual Review of Cell and Developmental Biology. 24, 447–473.","ieee":"J. Kleine Vehn and J. Friml, “Polar targeting and endocytic recycling in auxin-dependent plant development,” <i>Annual Review of Cell and Developmental Biology</i>, vol. 24. Annual Reviews, pp. 447–473, 2008.","ama":"Kleine Vehn J, Friml J. Polar targeting and endocytic recycling in auxin-dependent plant development. <i>Annual Review of Cell and Developmental Biology</i>. 2008;24:447-473. doi:<a href=\"https://doi.org/10.1146/annurev.cellbio.24.110707.175254\">10.1146/annurev.cellbio.24.110707.175254</a>"},"date_updated":"2021-01-12T07:40:39Z","_id":"3043","oa_version":"None","status":"public","language":[{"iso":"eng"}],"month":"11","publication_status":"published","intvolume":"        24","external_id":{"pmid":["    18837671"]},"abstract":[{"text":"Plant development is characterized by a profound phenotypic plasticity that often involves redefining of the developmental fate and polarity of cells within differentiated tissues. The plant hormone auxin and its directional intercellular transport play a major role in these processes because they provide positional information and link cell polarity with tissue patterning. This plant-specific mechanism of transport-dependent auxin gradients depends on subcellular dynamics of auxin transport components, in particular on endocytic recycling and polar targeting. Recent insights into these cellular processes in plants have revealed important parallels to yeast and animal systems, including clathrin-dependent endocytosis, retromer function, and transcytosis, but have also emphasized unique features of plant cells such as diversity of polar targeting pathways; integration of environmental signals into subcellular trafficking; and the link between endocytosis, cell polarity, and cell fate specification. We review these advances and focus on the translation of the subcellular dynamics to the regulation of whole-plant development.","lang":"eng"}],"quality_controlled":"1","pmid":1,"page":"447 - 473","author":[{"full_name":"Kleine Vehn, Jürgen","first_name":"Jürgen","last_name":"Kleine Vehn"},{"id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml","orcid":"0000-0002-8302-7596","full_name":"Friml, Jirí","first_name":"Jirí"}]}]