[{"doi":"10.1016/B978-0-12-374373-2.00012-1","year":"2010","publication_status":"published","_id":"2309","publication":"Physiology and Pathology of chloride transporters and channels in the nervous system","title":"The CLC family of chloride channels and transporters","citation":{"chicago":"Stauber, Tobias, Gaia Novarino, and Thomas Jentsch. “The CLC Family of Chloride Channels and Transporters.” In <i>Physiology and Pathology of Chloride Transporters and Channels in the Nervous System</i>, 209–31. Elsevier, 2010. <a href=\"https://doi.org/10.1016/B978-0-12-374373-2.00012-1\">https://doi.org/10.1016/B978-0-12-374373-2.00012-1</a>.","ieee":"T. Stauber, G. Novarino, and T. Jentsch, “The CLC family of chloride channels and transporters,” in <i>Physiology and Pathology of chloride transporters and channels in the nervous system</i>, Elsevier, 2010, pp. 209–231.","ama":"Stauber T, Novarino G, Jentsch T. The CLC family of chloride channels and transporters. In: <i>Physiology and Pathology of Chloride Transporters and Channels in the Nervous System</i>. Elsevier; 2010:209-231. doi:<a href=\"https://doi.org/10.1016/B978-0-12-374373-2.00012-1\">10.1016/B978-0-12-374373-2.00012-1</a>","apa":"Stauber, T., Novarino, G., &#38; Jentsch, T. (2010). The CLC family of chloride channels and transporters. In <i>Physiology and Pathology of chloride transporters and channels in the nervous system</i> (pp. 209–231). Elsevier. <a href=\"https://doi.org/10.1016/B978-0-12-374373-2.00012-1\">https://doi.org/10.1016/B978-0-12-374373-2.00012-1</a>","mla":"Stauber, Tobias, et al. “The CLC Family of Chloride Channels and Transporters.” <i>Physiology and Pathology of Chloride Transporters and Channels in the Nervous System</i>, Elsevier, 2010, pp. 209–31, doi:<a href=\"https://doi.org/10.1016/B978-0-12-374373-2.00012-1\">10.1016/B978-0-12-374373-2.00012-1</a>.","ista":"Stauber T, Novarino G, Jentsch T. 2010.The CLC family of chloride channels and transporters. In: Physiology and Pathology of chloride transporters and channels in the nervous system. , 209–231.","short":"T. Stauber, G. Novarino, T. Jentsch, in:, Physiology and Pathology of Chloride Transporters and Channels in the Nervous System, Elsevier, 2010, pp. 209–231."},"month":"01","page":"209 - 231","publist_id":"4616","abstract":[{"text":"The importance of chloride ions in cell physiology has not been fully recognized until recently, in spite of the fact that chloride (Cl-), together with bicarbonate, is the most abundant free anion in animal cells, and performs or determines fundamental biological functions in all tissues. For many years it was thought that Cl- was distributed in thermodynamic equilibrium across the plasma membrane of most cells. Research carried out during the last couple of decades has led to a dramatic change in this simplistic view. We now know that most animal cells, neurons included, exhibit a non-equilibrium distribution of Cl- across their plasma membranes. Over the last 10 to 15 years, with the growth of molecular biology and the advent of new optical methods, an enormous amount of exciting new information has become available on the molecular structure and function of Cl- channels and carriers. In nerve cells, Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control. Disruption of Cl- homeostasis in neurons underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation. This book is about how chloride ions are regulated and how they cross the plasma membrane of neurons. It spans from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases. * The first comprehensive book on the structure, molecular biology, cell physiology, and role in diseases of chloride transporters / channels in the nervous system in almost 20 years * Chloride is the most abundant free anion in animal cells. THis book summarizes and integrates for the first time the important research of the past two decades that has shown that Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control. * The first book that systematically discusses the result of disruption of Cl- homeostasis in neurons which underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation. * Spanning topics from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases. * Involves all of the leading researchers in the field. * INcludes an extensive introductory section that covers basic thermodynamic and kinetics aspects of Cl- transport, as well as current methods for studying Cl- regulation, spanning from fluorescent dyes in single cells to knock-out models to make the book available for a growing population of graduate students and postdocs entering the field.","lang":"eng"}],"status":"public","type":"book_chapter","day":"01","extern":1,"date_updated":"2021-01-12T06:56:41Z","date_created":"2018-12-11T11:56:54Z","date_published":"2010-01-01T00:00:00Z","author":[{"last_name":"Stauber","full_name":"Stauber, Tobias","first_name":"Tobias"},{"last_name":"Novarino","orcid":"0000-0002-7673-7178","full_name":"Gaia Novarino","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","first_name":"Gaia"},{"full_name":"Jentsch, Thomas J","first_name":"Thomas","last_name":"Jentsch"}],"quality_controlled":0,"publisher":"Elsevier"},{"date_published":"2010-02-15T00:00:00Z","quality_controlled":0,"author":[{"id":"35827D50-F248-11E8-B48F-1D18A9856A87","first_name":"Timothy D","full_name":"Timothy Browning","orcid":"0000-0002-8314-0177","last_name":"Browning"},{"last_name":"Colliot Thélène","full_name":"Colliot-Thélène, Jean-Louis","first_name":"Jean"}],"publisher":"Cambridge University Press","issue":"4","intvolume":"       146","date_created":"2018-12-11T11:45:20Z","date_updated":"2021-01-12T06:56:41Z","type":"journal_article","status":"public","extern":1,"day":"15","publist_id":"7673","abstract":[{"text":"Let X be a projective cubic hypersurface of dimension 11 or more, which is defined over ℚ. We show that X(ℚ) is non-empty provided that the cubic form defining X can be written as the sum of two forms that share no common variables.","lang":"eng"}],"page":"853 - 885","month":"02","citation":{"chicago":"Browning, Timothy D, and Jean Colliot Thélène. “Rational Points on Cubic Hypersurfaces That Split off a Form. With an Appendix by J-L Colliot-Thélène.” <i>Compositio Mathematica</i>. Cambridge University Press, 2010. <a href=\"https://doi.org/10.1112/S0010437X0900459X\">https://doi.org/10.1112/S0010437X0900459X</a>.","ama":"Browning TD, Colliot Thélène J. Rational points on cubic hypersurfaces that split off a form. With an appendix by J-L Colliot-Thélène. <i>Compositio Mathematica</i>. 2010;146(4):853-885. doi:<a href=\"https://doi.org/10.1112/S0010437X0900459X\">10.1112/S0010437X0900459X</a>","ieee":"T. D. Browning and J. Colliot Thélène, “Rational points on cubic hypersurfaces that split off a form. With an appendix by J-L Colliot-Thélène,” <i>Compositio Mathematica</i>, vol. 146, no. 4. Cambridge University Press, pp. 853–885, 2010.","apa":"Browning, T. D., &#38; Colliot Thélène, J. (2010). Rational points on cubic hypersurfaces that split off a form. With an appendix by J-L Colliot-Thélène. <i>Compositio Mathematica</i>. Cambridge University Press. <a href=\"https://doi.org/10.1112/S0010437X0900459X\">https://doi.org/10.1112/S0010437X0900459X</a>","mla":"Browning, Timothy D., and Jean Colliot Thélène. “Rational Points on Cubic Hypersurfaces That Split off a Form. With an Appendix by J-L Colliot-Thélène.” <i>Compositio Mathematica</i>, vol. 146, no. 4, Cambridge University Press, 2010, pp. 853–85, doi:<a href=\"https://doi.org/10.1112/S0010437X0900459X\">10.1112/S0010437X0900459X</a>.","short":"T.D. Browning, J. Colliot Thélène, Compositio Mathematica 146 (2010) 853–885.","ista":"Browning TD, Colliot Thélène J. 2010. Rational points on cubic hypersurfaces that split off a form. With an appendix by J-L Colliot-Thélène. Compositio Mathematica. 146(4), 853–885."},"acknowledgement":"EP/E053262/1\tEngineering and Physical Sciences Research Council","year":"2010","publication_status":"published","doi":"10.1112/S0010437X0900459X","volume":146,"_id":"231","title":"Rational points on cubic hypersurfaces that split off a form. With an appendix by J-L Colliot-Thélène","publication":"Compositio Mathematica"},{"page":"1398 - 1401","month":"06","citation":{"chicago":"Novarino, Gaia, Stefanie Weinert, Gesa Rickheit, and Thomas Jentsch. “Endosomal Chloride-Proton Exchange Rather than Chloride Conductance Is Crucial for Renal Endocytosis.” <i>Science</i>. American Association for the Advancement of Science, 2010. <a href=\"https://doi.org/10.1126/science.1188070\">https://doi.org/10.1126/science.1188070</a>.","ama":"Novarino G, Weinert S, Rickheit G, Jentsch T. Endosomal chloride-proton exchange rather than chloride conductance is crucial for renal endocytosis. <i>Science</i>. 2010;328(5984):1398-1401. doi:<a href=\"https://doi.org/10.1126/science.1188070\">10.1126/science.1188070</a>","ieee":"G. Novarino, S. Weinert, G. Rickheit, and T. Jentsch, “Endosomal chloride-proton exchange rather than chloride conductance is crucial for renal endocytosis,” <i>Science</i>, vol. 328, no. 5984. American Association for the Advancement of Science, pp. 1398–1401, 2010.","mla":"Novarino, Gaia, et al. “Endosomal Chloride-Proton Exchange Rather than Chloride Conductance Is Crucial for Renal Endocytosis.” <i>Science</i>, vol. 328, no. 5984, American Association for the Advancement of Science, 2010, pp. 1398–401, doi:<a href=\"https://doi.org/10.1126/science.1188070\">10.1126/science.1188070</a>.","apa":"Novarino, G., Weinert, S., Rickheit, G., &#38; Jentsch, T. (2010). Endosomal chloride-proton exchange rather than chloride conductance is crucial for renal endocytosis. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1188070\">https://doi.org/10.1126/science.1188070</a>","short":"G. Novarino, S. Weinert, G. Rickheit, T. Jentsch, Science 328 (2010) 1398–1401.","ista":"Novarino G, Weinert S, Rickheit G, Jentsch T. 2010. Endosomal chloride-proton exchange rather than chloride conductance is crucial for renal endocytosis. Science. 328(5984), 1398–1401."},"title":"Endosomal chloride-proton exchange rather than chloride conductance is crucial for renal endocytosis","_id":"2310","publication":"Science","volume":328,"year":"2010","publication_status":"published","doi":"10.1126/science.1188070","publisher":"American Association for the Advancement of Science","author":[{"full_name":"Gaia Novarino","first_name":"Gaia","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","last_name":"Novarino","orcid":"0000-0002-7673-7178"},{"first_name":"Stefanie","full_name":"Weinert, Stefanie","last_name":"Weinert"},{"full_name":"Rickheit, Gesa","first_name":"Gesa","last_name":"Rickheit"},{"last_name":"Jentsch","first_name":"Thomas","full_name":"Jentsch, Thomas J"}],"quality_controlled":0,"date_published":"2010-06-11T00:00:00Z","intvolume":"       328","date_created":"2018-12-11T11:56:55Z","date_updated":"2021-01-12T06:56:42Z","issue":"5984","day":"11","extern":1,"status":"public","type":"journal_article","abstract":[{"lang":"eng","text":"Loss of the endosomal anion transport protein ClC-5 impairs renal endocytosis and underlies human Dent's disease. ClC-5 is thought to promote endocytosis by facilitating endosomal acidification through the neutralization of proton pump currents. However, ClC-5 is a 2 chloride (Cl-)/proton (H+) exchanger rather than a Cl- channel. We generated mice that carry the uncoupling E211A (unc) mutation that converts CLC-5 into a pure CL- conductor. Adenosine triphosphate (ATP)-dependent acidification of renal endosomes was reduced in mice in which ClC-5 was knocked out, but normal in Clcn5unc mice. However, their proximal tubular endocytosis was also impaired. Thus, endosomal chloride concentration, which is raised by CLC-5 in exchange for protons accumulated by the H+-ATPase, may play a role in endocytosis."}],"publist_id":"4617"},{"year":"2010","publication_status":"published","doi":"10.1074/jbc.M110.115600","_id":"2311","title":"Role of ClC-5 in renal endocytosis is unique among ClC exchangers and does not require PY-motif-dependent ubiquitylation","publication":"Journal of Biological Chemistry","volume":285,"citation":{"short":"G. Rickheit, L. Wartosch, S. Schaffer, S. Stobrawa, G. Novarino, S. Weinert, T. Jentsch, Journal of Biological Chemistry 285 (2010) 17595–17603.","ista":"Rickheit G, Wartosch L, Schaffer S, Stobrawa S, Novarino G, Weinert S, Jentsch T. 2010. Role of ClC-5 in renal endocytosis is unique among ClC exchangers and does not require PY-motif-dependent ubiquitylation. Journal of Biological Chemistry. 285(23), 17595–17603.","mla":"Rickheit, Gesa, et al. “Role of ClC-5 in Renal Endocytosis Is Unique among ClC Exchangers and Does Not Require PY-Motif-Dependent Ubiquitylation.” <i>Journal of Biological Chemistry</i>, vol. 285, no. 23, American Society for Biochemistry and Molecular Biology, 2010, pp. 17595–603, doi:<a href=\"https://doi.org/10.1074/jbc.M110.115600\">10.1074/jbc.M110.115600</a>.","apa":"Rickheit, G., Wartosch, L., Schaffer, S., Stobrawa, S., Novarino, G., Weinert, S., &#38; Jentsch, T. (2010). Role of ClC-5 in renal endocytosis is unique among ClC exchangers and does not require PY-motif-dependent ubiquitylation. <i>Journal of Biological Chemistry</i>. American Society for Biochemistry and Molecular Biology. <a href=\"https://doi.org/10.1074/jbc.M110.115600\">https://doi.org/10.1074/jbc.M110.115600</a>","ieee":"G. Rickheit <i>et al.</i>, “Role of ClC-5 in renal endocytosis is unique among ClC exchangers and does not require PY-motif-dependent ubiquitylation,” <i>Journal of Biological Chemistry</i>, vol. 285, no. 23. American Society for Biochemistry and Molecular Biology, pp. 17595–17603, 2010.","ama":"Rickheit G, Wartosch L, Schaffer S, et al. Role of ClC-5 in renal endocytosis is unique among ClC exchangers and does not require PY-motif-dependent ubiquitylation. <i>Journal of Biological Chemistry</i>. 2010;285(23):17595-17603. doi:<a href=\"https://doi.org/10.1074/jbc.M110.115600\">10.1074/jbc.M110.115600</a>","chicago":"Rickheit, Gesa, Lena Wartosch, Sven Schaffer, Sandra Stobrawa, Gaia Novarino, Stefanie Weinert, and Thomas Jentsch. “Role of ClC-5 in Renal Endocytosis Is Unique among ClC Exchangers and Does Not Require PY-Motif-Dependent Ubiquitylation.” <i>Journal of Biological Chemistry</i>. American Society for Biochemistry and Molecular Biology, 2010. <a href=\"https://doi.org/10.1074/jbc.M110.115600\">https://doi.org/10.1074/jbc.M110.115600</a>."},"month":"06","page":"17595 - 17603","publist_id":"4618","abstract":[{"lang":"eng","text":"Inactivation of the mainly endosomal 2Cl-/H+- exchanger ClC-5 severely impairs endocytosis in renal proximal tubules and underlies the human kidney stone disorder Dent's disease. In heterologous expression systems, interaction of the E3 ubiquitin ligasesWWP2and Nedd4-2 with a &quot;PY-motif&quot; in the cytoplasmic C terminus of ClC-5 stimulates its internalization from the plasma membrane and may influence receptor-mediated endocytosis. We asked whether this interaction is relevant in vivo and generated mice in which the PY-motif was destroyed by a point mutation. Unlike ClC-5 knock-out mice, these knock-in mice displayed neither low molecular weight proteinuria nor hyperphosphaturia, and both receptor-mediated and fluid-phase endocytosis were normal. The abundances and localizations of the endocytic receptor megalin and of the Na+-coupled phosphate transporter NaPi-2a (Npt2) were not changed, either. To explore whether the discrepancy in results from heterologous expression studies might be due to heteromerization of ClC-5 with ClC-3 or ClC-4 in vivo, we studied knock-in mice additionally deleted for those related transporters. Disruption of neither ClC-3 nor ClC-4 led to proteinuria or impaired proximal tubular endocytosis by itself, nor in combination with the PY-mutant of ClC-5. Endocytosis of cells lacking ClC-5 was not impaired further when ClC-3 or ClC-4 was additionally deleted. We conclude that ClC-5 is unique among CLC proteins in being crucial for proximal tubular endocytosis and that PY-motif-dependent ubiquitylation of ClC-5 is dispensable for this role."}],"type":"journal_article","status":"public","extern":1,"day":"04","issue":"23","date_created":"2018-12-11T11:56:55Z","intvolume":"       285","date_updated":"2021-01-12T06:56:42Z","date_published":"2010-06-04T00:00:00Z","quality_controlled":0,"author":[{"last_name":"Rickheit","full_name":"Rickheit, Gesa","first_name":"Gesa"},{"full_name":"Wartosch, Lena","first_name":"Lena","last_name":"Wartosch"},{"last_name":"Schaffer","first_name":"Sven","full_name":"Schaffer, Sven"},{"last_name":"Stobrawa","full_name":"Stobrawa, Sandra M","first_name":"Sandra"},{"id":"3E57A680-F248-11E8-B48F-1D18A9856A87","first_name":"Gaia","full_name":"Gaia Novarino","orcid":"0000-0002-7673-7178","last_name":"Novarino"},{"full_name":"Weinert, Stefanie","first_name":"Stefanie","last_name":"Weinert"},{"first_name":"Thomas","full_name":"Jentsch, Thomas J","last_name":"Jentsch"}],"publisher":"American Society for Biochemistry and Molecular Biology"},{"day":"17","extern":"1","status":"public","type":"journal_article","abstract":[{"text":"We study the average order of the divisor function, as it ranges over the values of binary quartic forms that are reducible over ℚ.","lang":"eng"}],"publisher":"Walter de Gruyter","quality_controlled":"1","external_id":{"arxiv":["0808.2340"]},"date_created":"2018-12-11T11:45:20Z","year":"2010","language":[{"iso":"eng"}],"page":"1 - 44","month":"09","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/0808.2340"}],"article_type":"original","publist_id":"7672","oa_version":"Preprint","author":[{"last_name":"De La Bretèche","first_name":"Régis","full_name":"De La Bretèche, Régis"},{"orcid":"0000-0002-8314-0177","last_name":"Browning","id":"35827D50-F248-11E8-B48F-1D18A9856A87","full_name":"Browning, Timothy D","first_name":"Timothy D"}],"date_published":"2010-09-17T00:00:00Z","date_updated":"2021-01-12T06:56:45Z","issue":"646","oa":1,"citation":{"mla":"De La Bretèche, Régis, and Timothy D. Browning. “Le Problème Des Diviseurs Pour Des Formes Binaires de Degré 4.” <i>Journal Fur Die Reine Und Angewandte Mathematik</i>, no. 646, Walter de Gruyter, 2010, pp. 1–44, doi:<a href=\"https://doi.org/10.1515/CRELLE.2010.064\">10.1515/CRELLE.2010.064</a>.","apa":"De La Bretèche, R., &#38; Browning, T. D. (2010). Le problème des diviseurs pour des formes binaires de degré 4. <i>Journal Fur Die Reine Und Angewandte Mathematik</i>. Walter de Gruyter. <a href=\"https://doi.org/10.1515/CRELLE.2010.064\">https://doi.org/10.1515/CRELLE.2010.064</a>","short":"R. De La Bretèche, T.D. Browning, Journal Fur Die Reine Und Angewandte Mathematik (2010) 1–44.","ista":"De La Bretèche R, Browning TD. 2010. Le problème des diviseurs pour des formes binaires de degré 4. Journal fur die Reine und Angewandte Mathematik. (646), 1–44.","chicago":"De La Bretèche, Régis, and Timothy D Browning. “Le Problème Des Diviseurs Pour Des Formes Binaires de Degré 4.” <i>Journal Fur Die Reine Und Angewandte Mathematik</i>. Walter de Gruyter, 2010. <a href=\"https://doi.org/10.1515/CRELLE.2010.064\">https://doi.org/10.1515/CRELLE.2010.064</a>.","ama":"De La Bretèche R, Browning TD. Le problème des diviseurs pour des formes binaires de degré 4. <i>Journal fur die Reine und Angewandte Mathematik</i>. 2010;(646):1-44. doi:<a href=\"https://doi.org/10.1515/CRELLE.2010.064\">10.1515/CRELLE.2010.064</a>","ieee":"R. De La Bretèche and T. D. Browning, “Le problème des diviseurs pour des formes binaires de degré 4,” <i>Journal fur die Reine und Angewandte Mathematik</i>, no. 646. Walter de Gruyter, pp. 1–44, 2010."},"arxiv":1,"article_processing_charge":"No","publication":"Journal fur die Reine und Angewandte Mathematik","title":"Le problème des diviseurs pour des formes binaires de degré 4","_id":"232","publication_status":"published","doi":"10.1515/CRELLE.2010.064","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"},{"page":"523 - 535","main_file_link":[{"open_access":"1","url":"http://arxiv.org/abs/0909.5449"}],"month":"03","oa":1,"conference":{"name":"ICMP: International Congress on Mathematical Physics"},"citation":{"short":"R. Frank, É. Lieb, R. Seiringer, in:, World Scientific Publishing, 2010, pp. 523–535.","ista":"Frank R, Lieb É, Seiringer R. 2010.  Equivalence of Sobolev inequalities and Lieb-Thirring inequalities. ICMP: International Congress on Mathematical Physics, 523–535.","apa":"Frank, R., Lieb, É., &#38; Seiringer, R. (2010).  Equivalence of Sobolev inequalities and Lieb-Thirring inequalities (pp. 523–535). Presented at the ICMP: International Congress on Mathematical Physics, World Scientific Publishing. <a href=\"https://doi.org/10.1142/9789814304634_0045 \">https://doi.org/10.1142/9789814304634_0045 </a>","mla":"Frank, Rupert, et al. <i> Equivalence of Sobolev Inequalities and Lieb-Thirring Inequalities</i>. World Scientific Publishing, 2010, pp. 523–35, doi:<a href=\"https://doi.org/10.1142/9789814304634_0045 \">10.1142/9789814304634_0045 </a>.","ama":"Frank R, Lieb É, Seiringer R.  Equivalence of Sobolev inequalities and Lieb-Thirring inequalities. In: World Scientific Publishing; 2010:523-535. doi:<a href=\"https://doi.org/10.1142/9789814304634_0045 \">10.1142/9789814304634_0045 </a>","ieee":"R. Frank, É. Lieb, and R. Seiringer, “ Equivalence of Sobolev inequalities and Lieb-Thirring inequalities,” presented at the ICMP: International Congress on Mathematical Physics, 2010, pp. 523–535.","chicago":"Frank, Rupert, Élliott Lieb, and Robert Seiringer. “ Equivalence of Sobolev Inequalities and Lieb-Thirring Inequalities,” 523–35. World Scientific Publishing, 2010. <a href=\"https://doi.org/10.1142/9789814304634_0045 \">https://doi.org/10.1142/9789814304634_0045 </a>."},"_id":"2322","title":" Equivalence of Sobolev inequalities and Lieb-Thirring inequalities","doi":"10.1142/9789814304634_0045 ","year":"2010","publication_status":"published","author":[{"first_name":"Rupert","full_name":"Frank, Rupert L","last_name":"Frank"},{"first_name":"Élliott","full_name":"Lieb, Élliott H","last_name":"Lieb"},{"orcid":"0000-0002-6781-0521","last_name":"Seiringer","first_name":"Robert","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","full_name":"Robert Seiringer"}],"publisher":"World Scientific Publishing","quality_controlled":0,"date_published":"2010-03-31T00:00:00Z","date_updated":"2021-01-12T06:56:46Z","date_created":"2018-12-11T11:56:59Z","extern":1,"day":"31","status":"public","type":"conference","publist_id":"4605"},{"date_created":"2018-12-11T11:56:59Z","date_updated":"2021-01-12T06:56:46Z","publisher":"World Scientific Publishing","author":[{"last_name":"Seiringer","orcid":"0000-0002-6781-0521","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","full_name":"Robert Seiringer","first_name":"Robert"}],"quality_controlled":0,"date_published":"2010-03-31T00:00:00Z","abstract":[{"text":"Since the first experimental realization of Bose-Einstein condensation in cold atomic gases in 1995 there has been a surge of activity in this field. Ingenious experiments have allowed us to probe matter close to zero temperature and reveal some of the fascinating effects quantum mechanics has bestowed on nature. It is a challenge for mathematical physicists to understand these various phenomena from first principles, that is, starting from the underlying many-body Schrödinger equation. Recent progress in this direction concerns mainly equilibrium properties of dilute, cold quantum gases. We shall explain some of the results in this article, and describe the mathematics involved in understanding these phenomena. Topics include the ground state energy and the free energy at positive temperature, the effect of interparticle interaction on the critical temperature for Bose-Einstein condensation, as well as the occurrence of superfluidity and quantized vortices in rapidly rotating gases.","lang":"eng"}],"publist_id":"4604","extern":1,"day":"31","type":"conference","status":"public","month":"03","main_file_link":[{"open_access":"1","url":"http://arxiv.org/abs/0908.3686"}],"page":"231 - 245","title":"Hot topics on cold gases","_id":"2323","year":"2010","publication_status":"published","doi":"10.1142/9789814304634_0013","conference":{"name":"ICMP: International Congress on Mathematical Physics"},"oa":1,"citation":{"apa":"Seiringer, R. (2010). Hot topics on cold gases (pp. 231–245). Presented at the ICMP: International Congress on Mathematical Physics, World Scientific Publishing. <a href=\"https://doi.org/10.1142/9789814304634_0013\">https://doi.org/10.1142/9789814304634_0013</a>","mla":"Seiringer, Robert. <i>Hot Topics on Cold Gases</i>. World Scientific Publishing, 2010, pp. 231–45, doi:<a href=\"https://doi.org/10.1142/9789814304634_0013\">10.1142/9789814304634_0013</a>.","short":"R. Seiringer, in:, World Scientific Publishing, 2010, pp. 231–245.","ista":"Seiringer R. 2010. Hot topics on cold gases. ICMP: International Congress on Mathematical Physics, 231–245.","chicago":"Seiringer, Robert. “Hot Topics on Cold Gases,” 231–45. World Scientific Publishing, 2010. <a href=\"https://doi.org/10.1142/9789814304634_0013\">https://doi.org/10.1142/9789814304634_0013</a>.","ieee":"R. Seiringer, “Hot topics on cold gases,” presented at the ICMP: International Congress on Mathematical Physics, 2010, pp. 231–245.","ama":"Seiringer R. Hot topics on cold gases. In: World Scientific Publishing; 2010:231-245. doi:<a href=\"https://doi.org/10.1142/9789814304634_0013\">10.1142/9789814304634_0013</a>"}},{"status":"public","type":"book_chapter","alternative_title":["International Mathematical Series"],"extern":1,"day":"01","publist_id":"4603","abstract":[{"lang":"eng","text":"We determine the sharp constant in the Hardy inequality for fractional Sobolev spaces on half-spaces. Our proof relies on a nonlinear and nonlocal version of the ground state representation."}],"date_published":"2010-01-01T00:00:00Z","author":[{"full_name":"Frank, Rupert L","first_name":"Rupert","last_name":"Frank"},{"orcid":"0000-0002-6781-0521","last_name":"Seiringer","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","full_name":"Robert Seiringer","first_name":"Robert"}],"publisher":"Springer","quality_controlled":0,"date_updated":"2021-01-12T06:56:46Z","intvolume":"        11","date_created":"2018-12-11T11:56:59Z","citation":{"apa":"Frank, R., &#38; Seiringer, R. (2010). Sharp fractional Hardy inequalities in half-spaces. In <i>Around the Research of Vladimir Maz’ya I</i> (Vol. 11, pp. 161–167). Springer. <a href=\"https://doi.org/10.1007/978-1-4419-1341-8_6\">https://doi.org/10.1007/978-1-4419-1341-8_6</a>","mla":"Frank, Rupert, and Robert Seiringer. “Sharp Fractional Hardy Inequalities in Half-Spaces.” <i>Around the Research of Vladimir Maz’ya I</i>, vol. 11, Springer, 2010, pp. 161–67, doi:<a href=\"https://doi.org/10.1007/978-1-4419-1341-8_6\">10.1007/978-1-4419-1341-8_6</a>.","short":"R. Frank, R. Seiringer, in:, Around the Research of Vladimir Maz’ya I, Springer, 2010, pp. 161–167.","ista":"Frank R, Seiringer R. 2010.Sharp fractional Hardy inequalities in half-spaces. In: Around the Research of Vladimir Maz’ya I. International Mathematical Series, vol. 11, 161–167.","ieee":"R. Frank and R. Seiringer, “Sharp fractional Hardy inequalities in half-spaces,” in <i>Around the Research of Vladimir Maz’ya I</i>, vol. 11, Springer, 2010, pp. 161–167.","ama":"Frank R, Seiringer R. Sharp fractional Hardy inequalities in half-spaces. In: <i>Around the Research of Vladimir Maz’ya I</i>. Vol 11. Springer; 2010:161-167. doi:<a href=\"https://doi.org/10.1007/978-1-4419-1341-8_6\">10.1007/978-1-4419-1341-8_6</a>","chicago":"Frank, Rupert, and Robert Seiringer. “Sharp Fractional Hardy Inequalities in Half-Spaces.” In <i>Around the Research of Vladimir Maz’ya I</i>, 11:161–67. Springer, 2010. <a href=\"https://doi.org/10.1007/978-1-4419-1341-8_6\">https://doi.org/10.1007/978-1-4419-1341-8_6</a>."},"oa":1,"doi":"10.1007/978-1-4419-1341-8_6","year":"2010","publication_status":"published","volume":11,"_id":"2324","title":"Sharp fractional Hardy inequalities in half-spaces","publication":"Around the Research of Vladimir Maz'ya I","page":"161 - 167","main_file_link":[{"open_access":"1","url":"http://arxiv.org/abs/0906.1561"}],"month":"01"},{"main_file_link":[{"open_access":"1","url":"http://arxiv.org/abs/0808.3737"}],"month":"03","page":"489 - 499","_id":"2389","volume":283,"title":"Asymptotic behavior of eigenvalues of Schrödinger type operators with degenerate kinetic energy","publication":"Mathematische Nachrichten","doi":"10.1002/mana.200810195","publication_status":"published","year":"2010","oa":1,"citation":{"mla":"Hainzl, Christian, and Robert Seiringer. “Asymptotic Behavior of Eigenvalues of Schrödinger Type Operators with Degenerate Kinetic Energy.” <i>Mathematische Nachrichten</i>, vol. 283, no. 3, Wiley-Blackwell, 2010, pp. 489–99, doi:<a href=\"https://doi.org/10.1002/mana.200810195\">10.1002/mana.200810195</a>.","apa":"Hainzl, C., &#38; Seiringer, R. (2010). Asymptotic behavior of eigenvalues of Schrödinger type operators with degenerate kinetic energy. <i>Mathematische Nachrichten</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1002/mana.200810195\">https://doi.org/10.1002/mana.200810195</a>","short":"C. Hainzl, R. Seiringer, Mathematische Nachrichten 283 (2010) 489–499.","ista":"Hainzl C, Seiringer R. 2010. Asymptotic behavior of eigenvalues of Schrödinger type operators with degenerate kinetic energy. Mathematische Nachrichten. 283(3), 489–499.","ama":"Hainzl C, Seiringer R. Asymptotic behavior of eigenvalues of Schrödinger type operators with degenerate kinetic energy. <i>Mathematische Nachrichten</i>. 2010;283(3):489-499. doi:<a href=\"https://doi.org/10.1002/mana.200810195\">10.1002/mana.200810195</a>","ieee":"C. Hainzl and R. Seiringer, “Asymptotic behavior of eigenvalues of Schrödinger type operators with degenerate kinetic energy,” <i>Mathematische Nachrichten</i>, vol. 283, no. 3. Wiley-Blackwell, pp. 489–499, 2010.","chicago":"Hainzl, Christian, and Robert Seiringer. “Asymptotic Behavior of Eigenvalues of Schrödinger Type Operators with Degenerate Kinetic Energy.” <i>Mathematische Nachrichten</i>. Wiley-Blackwell, 2010. <a href=\"https://doi.org/10.1002/mana.200810195\">https://doi.org/10.1002/mana.200810195</a>."},"date_updated":"2021-01-12T06:57:11Z","intvolume":"       283","date_created":"2018-12-11T11:57:23Z","issue":"3","author":[{"last_name":"Hainzl","full_name":"Hainzl, Christian","first_name":"Christian"},{"id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","full_name":"Robert Seiringer","first_name":"Robert","orcid":"0000-0002-6781-0521","last_name":"Seiringer"}],"publisher":"Wiley-Blackwell","quality_controlled":0,"date_published":"2010-03-01T00:00:00Z","abstract":[{"text":"We study the eigenvalues of Schrödinger type operators T + λV and their asymptotic behavior in the small coupling limit λ → 0, in the case where the symbol of the kinetic energy, T (p), strongly degenerates on a non-trivial manifold of codimension one.","lang":"eng"}],"publist_id":"4537","day":"01","extern":1,"type":"journal_article","status":"public"},{"date_published":"2010-01-01T00:00:00Z","author":[{"last_name":"Frank","full_name":"Frank, Rupert L","first_name":"Rupert"},{"last_name":"Lieb","first_name":"Élliott","full_name":"Lieb, Élliott H"},{"full_name":"Robert Seiringer","first_name":"Robert","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","last_name":"Seiringer","orcid":"0000-0002-6781-0521"},{"last_name":"Thomas","first_name":"Lawrence","full_name":"Thomas, Lawrence E"}],"quality_controlled":0,"publisher":"American Physical Society","issue":"21","date_updated":"2021-01-12T06:57:12Z","date_created":"2018-12-11T11:57:24Z","intvolume":"       104","status":"public","type":"journal_article","extern":1,"day":"01","publist_id":"4536","abstract":[{"text":"The binding of polarons, or its absence, is an old and subtle topic. Here we prove two things rigorously. First, the transition from many-body collapse to the existence of a thermodynamic limit for N polarons occurs precisely at U=2α, where U is the electronic Coulomb repulsion and α is the polaron coupling constant. Second, if U is large enough, there is no multipolaron binding of any kind. Considering the known fact that there is binding for some U&gt;2α, these conclusions are not obvious and their proof has been an open problem for some time.","lang":"eng"}],"main_file_link":[{"open_access":"1","url":"http://arxiv.org/abs/1004.1196"}],"month":"01","citation":{"mla":"Frank, Rupert, et al. “Bipolaron and N-Polaron Binding Energies.” <i>Physical Review Letters</i>, vol. 104, no. 21, American Physical Society, 2010, doi:<a href=\"https://doi.org/10.1103/PhysRevLett.104.210402\">10.1103/PhysRevLett.104.210402</a>.","apa":"Frank, R., Lieb, É., Seiringer, R., &#38; Thomas, L. (2010). Bipolaron and N-polaron binding energies. <i>Physical Review Letters</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevLett.104.210402\">https://doi.org/10.1103/PhysRevLett.104.210402</a>","ista":"Frank R, Lieb É, Seiringer R, Thomas L. 2010. Bipolaron and N-polaron binding energies. Physical Review Letters. 104(21).","short":"R. Frank, É. Lieb, R. Seiringer, L. Thomas, Physical Review Letters 104 (2010).","ama":"Frank R, Lieb É, Seiringer R, Thomas L. Bipolaron and N-polaron binding energies. <i>Physical Review Letters</i>. 2010;104(21). doi:<a href=\"https://doi.org/10.1103/PhysRevLett.104.210402\">10.1103/PhysRevLett.104.210402</a>","ieee":"R. Frank, É. Lieb, R. Seiringer, and L. Thomas, “Bipolaron and N-polaron binding energies,” <i>Physical Review Letters</i>, vol. 104, no. 21. American Physical Society, 2010.","chicago":"Frank, Rupert, Élliott Lieb, Robert Seiringer, and Lawrence Thomas. “Bipolaron and N-Polaron Binding Energies.” <i>Physical Review Letters</i>. American Physical Society, 2010. <a href=\"https://doi.org/10.1103/PhysRevLett.104.210402\">https://doi.org/10.1103/PhysRevLett.104.210402</a>."},"oa":1,"doi":"10.1103/PhysRevLett.104.210402","year":"2010","publication_status":"published","_id":"2392","volume":104,"title":"Bipolaron and N-polaron binding energies","publication":"Physical Review Letters"},{"file":[{"access_level":"open_access","file_name":"IST-2018-939-v1+1_2010_Kupczok_Accuracy_of.pdf","content_type":"application/pdf","file_id":"4739","checksum":"e2497285388bc4da629bafb46662eb43","file_size":723929,"creator":"system","relation":"main_file","date_created":"2018-12-12T10:09:16Z","date_updated":"2020-07-14T12:45:40Z"}],"publication_status":"published","doi":"10.1186/1748-7188-5-37","publication":"Algorithms for Molecular Biology","_id":"2409","title":"Accuracy of phylogeny reconstruction methods combining overlapping gene data sets ","article_number":"37","citation":{"ieee":"A. Kupczok, H. Schmidt, and A. Von Haeseler, “Accuracy of phylogeny reconstruction methods combining overlapping gene data sets ,” <i>Algorithms for Molecular Biology</i>, vol. 5, no. 1. BioMed Central, 2010.","ama":"Kupczok A, Schmidt H, Von Haeseler A. Accuracy of phylogeny reconstruction methods combining overlapping gene data sets . <i>Algorithms for Molecular Biology</i>. 2010;5(1). doi:<a href=\"https://doi.org/10.1186/1748-7188-5-37\">10.1186/1748-7188-5-37</a>","chicago":"Kupczok, Anne, Heiko Schmidt, and Arndt Von Haeseler. “Accuracy of Phylogeny Reconstruction Methods Combining Overlapping Gene Data Sets .” <i>Algorithms for Molecular Biology</i>. BioMed Central, 2010. <a href=\"https://doi.org/10.1186/1748-7188-5-37\">https://doi.org/10.1186/1748-7188-5-37</a>.","ista":"Kupczok A, Schmidt H, Von Haeseler A. 2010. Accuracy of phylogeny reconstruction methods combining overlapping gene data sets . Algorithms for Molecular Biology. 5(1), 37.","short":"A. Kupczok, H. Schmidt, A. Von Haeseler, Algorithms for Molecular Biology 5 (2010).","apa":"Kupczok, A., Schmidt, H., &#38; Von Haeseler, A. (2010). Accuracy of phylogeny reconstruction methods combining overlapping gene data sets . <i>Algorithms for Molecular Biology</i>. BioMed Central. <a href=\"https://doi.org/10.1186/1748-7188-5-37\">https://doi.org/10.1186/1748-7188-5-37</a>","mla":"Kupczok, Anne, et al. “Accuracy of Phylogeny Reconstruction Methods Combining Overlapping Gene Data Sets .” <i>Algorithms for Molecular Biology</i>, vol. 5, no. 1, 37, BioMed Central, 2010, doi:<a href=\"https://doi.org/10.1186/1748-7188-5-37\">10.1186/1748-7188-5-37</a>."},"acknowledgement":"Financial support from the Wiener Wissenschafts-, Forschungs- and Technologiefonds (WWTF) is greatly appreciated. A.v.H. acknowledges support from the German Research Foundation (DFG, SPP-1174).","oa":1,"user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","publist_id":"4517","pubrep_id":"939","oa_version":"Published Version","scopus_import":1,"issue":"1","intvolume":"         5","date_updated":"2021-01-12T06:57:18Z","date_published":"2010-12-06T00:00:00Z","author":[{"last_name":"Kupczok","full_name":"Kupczok, Anne","first_name":"Anne","id":"2BB22BC2-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Schmidt, Heiko","first_name":"Heiko","last_name":"Schmidt"},{"last_name":"Von Haeseler","first_name":"Arndt","full_name":"Von Haeseler, Arndt"}],"year":"2010","language":[{"iso":"eng"}],"volume":5,"month":"12","department":[{"_id":"JoBo"}],"ddc":["576"],"has_accepted_license":"1","abstract":[{"text":"Background: The availability of many gene alignments with overlapping taxon sets raises the question of which strategy is the best to infer species phylogenies from multiple gene information. Methods and programs abound that use the gene alignment in different ways to reconstruct the species tree. In particular, different methods combine the original data at different points along the way from the underlying sequences to the final tree. Accordingly, they are classified into superalignment, supertree and medium-level approaches. Here, we present a simulation study to compare different methods from each of these three approaches.\r\n\r\nResults: We observe that superalignment methods usually outperform the other approaches over a wide range of parameters including sparse data and gene-specific evolutionary parameters. In the presence of high incongruency among gene trees, however, other combination methods show better performance than the superalignment approach. Surprisingly, some supertree and medium-level methods exhibit, on average, worse results than a single gene phylogeny with complete taxon information.\r\n\r\nConclusions: For some methods, using the reconstructed gene tree as an estimation of the species tree is superior to the combination of incomplete information. Superalignment usually performs best since it is less susceptible to stochastic error. Supertree methods can outperform superalignment in the presence of gene-tree conflict.","lang":"eng"}],"tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)"},"type":"journal_article","status":"public","day":"06","file_date_updated":"2020-07-14T12:45:40Z","date_created":"2018-12-11T11:57:30Z","quality_controlled":"1","publisher":"BioMed Central"},{"status":"public","type":"journal_article","extern":1,"day":"01","publist_id":"4472","abstract":[{"text":"We consider a generalization of the van Kampen-Flores Theorem and relate it to the long-standing g-conjecture for simplicial spheres.\n","lang":"eng"}],"date_published":"2010-11-01T00:00:00Z","author":[{"full_name":"Nevo, Eran","first_name":"Eran","last_name":"Nevo"},{"full_name":"Uli Wagner","first_name":"Uli","id":"36690CA2-F248-11E8-B48F-1D18A9856A87","last_name":"Wagner","orcid":"0000-0002-1494-0568"}],"quality_controlled":0,"publisher":"Springer","issue":"1","date_updated":"2021-01-12T06:57:28Z","date_created":"2018-12-11T11:57:38Z","intvolume":"       174","citation":{"short":"E. Nevo, U. Wagner, Israel Journal of Mathematics 174 (2010) 381–402.","ista":"Nevo E, Wagner U. 2010. On the embeddability of skeleta of spheres. Israel Journal of Mathematics. 174(1), 381–402.","apa":"Nevo, E., &#38; Wagner, U. (2010). On the embeddability of skeleta of spheres. <i>Israel Journal of Mathematics</i>. Springer. <a href=\"https://doi.org/10.1007/s11856-009-0119-5\">https://doi.org/10.1007/s11856-009-0119-5</a>","mla":"Nevo, Eran, and Uli Wagner. “On the Embeddability of Skeleta of Spheres.” <i>Israel Journal of Mathematics</i>, vol. 174, no. 1, Springer, 2010, pp. 381–402, doi:<a href=\"https://doi.org/10.1007/s11856-009-0119-5\">10.1007/s11856-009-0119-5</a>.","ieee":"E. Nevo and U. Wagner, “On the embeddability of skeleta of spheres,” <i>Israel Journal of Mathematics</i>, vol. 174, no. 1. Springer, pp. 381–402, 2010.","ama":"Nevo E, Wagner U. On the embeddability of skeleta of spheres. <i>Israel Journal of Mathematics</i>. 2010;174(1):381-402. doi:<a href=\"https://doi.org/10.1007/s11856-009-0119-5\">10.1007/s11856-009-0119-5</a>","chicago":"Nevo, Eran, and Uli Wagner. “On the Embeddability of Skeleta of Spheres.” <i>Israel Journal of Mathematics</i>. Springer, 2010. <a href=\"https://doi.org/10.1007/s11856-009-0119-5\">https://doi.org/10.1007/s11856-009-0119-5</a>."},"doi":"10.1007/s11856-009-0119-5","year":"2010","publication_status":"published","_id":"2435","volume":174,"publication":"Israel Journal of Mathematics","title":"On the embeddability of skeleta of spheres","page":"381 - 402","month":"11"},{"type":"journal_article","status":"public","extern":"1","day":"15","abstract":[{"text":"In a new study published in this issue of Developmental Cell, Krouk et al. reveal a surprising mechanism by which plant root systems adapt their architecture for soil exploitation. The dual transporter NRT1.1 uses both nitrate and the plant hormone auxin as substrates, enabling soil nitrate availability to regulate auxin-driven lateral root development.","lang":"eng"}],"publisher":"Cell Press","quality_controlled":"1","external_id":{"pmid":["    20627068"]},"date_created":"2018-12-11T11:57:41Z","year":"2010","language":[{"iso":"eng"}],"volume":18,"page":"877 - 878","pmid":1,"month":"06","main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pubmed/20627068","open_access":"1"}],"publist_id":"4461","oa_version":"Published Version","date_published":"2010-06-15T00:00:00Z","author":[{"full_name":"Beeckman, Tom","first_name":"Tom","last_name":"Beeckman"},{"orcid":"0000-0002-8302-7596","last_name":"Friml","first_name":"Jirí","full_name":"Friml, Jirí","id":"4159519E-F248-11E8-B48F-1D18A9856A87"}],"issue":"6","intvolume":"        18","date_updated":"2021-01-12T06:57:31Z","citation":{"short":"T. Beeckman, J. Friml, Developmental Cell 18 (2010) 877–878.","ista":"Beeckman T, Friml J. 2010. Nitrate Contra Auxin: Nutrient Sensing by roots. Developmental Cell. 18(6), 877–878.","apa":"Beeckman, T., &#38; Friml, J. (2010). Nitrate Contra Auxin: Nutrient Sensing by roots. <i>Developmental Cell</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.devcel.2010.05.020\">https://doi.org/10.1016/j.devcel.2010.05.020</a>","mla":"Beeckman, Tom, and Jiří Friml. “Nitrate Contra Auxin: Nutrient Sensing by Roots.” <i>Developmental Cell</i>, vol. 18, no. 6, Cell Press, 2010, pp. 877–78, doi:<a href=\"https://doi.org/10.1016/j.devcel.2010.05.020\">10.1016/j.devcel.2010.05.020</a>.","chicago":"Beeckman, Tom, and Jiří Friml. “Nitrate Contra Auxin: Nutrient Sensing by Roots.” <i>Developmental Cell</i>. Cell Press, 2010. <a href=\"https://doi.org/10.1016/j.devcel.2010.05.020\">https://doi.org/10.1016/j.devcel.2010.05.020</a>.","ama":"Beeckman T, Friml J. Nitrate Contra Auxin: Nutrient Sensing by roots. <i>Developmental Cell</i>. 2010;18(6):877-878. doi:<a href=\"https://doi.org/10.1016/j.devcel.2010.05.020\">10.1016/j.devcel.2010.05.020</a>","ieee":"T. Beeckman and J. Friml, “Nitrate Contra Auxin: Nutrient Sensing by roots,” <i>Developmental Cell</i>, vol. 18, no. 6. Cell Press, pp. 877–878, 2010."},"oa":1,"publication_status":"published","doi":"10.1016/j.devcel.2010.05.020","title":"Nitrate Contra Auxin: Nutrient Sensing by roots","_id":"2442","publication":"Developmental Cell","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87"},{"publisher":"National Academy of Sciences","quality_controlled":0,"author":[{"last_name":"Fukata","full_name":"Fukata, Yuko","first_name":"Yuko"},{"full_name":"Lovero, Kathryn L","first_name":"Kathryn","last_name":"Lovero"},{"first_name":"Tsuyoshi","full_name":"Iwanaga, Tsuyoshi","last_name":"Iwanaga"},{"first_name":"Atsushi","full_name":"Watanabe, Atsushi","last_name":"Watanabe"},{"first_name":"Norihiko","full_name":"Yokoi, Norihiko","last_name":"Yokoi"},{"full_name":"Tabuchi, Katsuhiko","first_name":"Katsuhiko","last_name":"Tabuchi"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","full_name":"Ryuichi Shigemoto","last_name":"Shigemoto","orcid":"0000-0001-8761-9444"},{"full_name":"Nicoll, Roger A","first_name":"Roger","last_name":"Nicoll"},{"full_name":"Fukata, Masaki","first_name":"Masaki","last_name":"Fukata"}],"date_published":"2010-02-23T00:00:00Z","date_created":"2018-12-11T11:58:03Z","intvolume":"       107","date_updated":"2021-01-12T06:57:53Z","issue":"8","day":"23","extern":1,"type":"journal_article","status":"public","abstract":[{"lang":"eng","text":"Epilepsy is a devastating and poorly understood disease. Mutations in a secreted neuronal protein, leucine-rich glioma inactivated 1 (LGI1), were reported in patients with an inherited form of human epilepsy, autosomal dominant partial epilepsy with auditory features (ADPEAF). Here, we report an essential role of LGI1 as an antiepileptogenic ligand. We find that loss of LGI1 in mice (LGI1-/-) causes lethal epilepsy, which is specifically rescued by the neuronal expression of LGI1 transgene, but not LGI3. Moreover, heterozygous mice for the LGI1 mutation (LGI1+/-) show lowered seizure thresholds. Extracellularly secreted LGI1 links two epilepsy-related receptors, ADAM22 and ADAM23, in the brain and organizes a transsynaptic protein complex that includes presynaptic potassium channels and postsynaptic AMPA receptor scaffolds. A lack of LGI1 disrupts this synaptic protein connection and selectively reduces AMPA receptor-mediated synaptic transmission in the hippocampus. Thus, LGI1 may serve as a major determinant of brain excitation, and the LGI1 gene-targeted mouse provides a good model for human epilepsy."}],"publist_id":"4398","page":"3799 - 3804","month":"02","citation":{"ista":"Fukata Y, Lovero K, Iwanaga T, Watanabe A, Yokoi N, Tabuchi K, Shigemoto R, Nicoll R, Fukata M. 2010. Disruption of LGI1-linked synaptic complex causes abnormal synaptic transmission and epilepsy. PNAS. 107(8), 3799–3804.","short":"Y. Fukata, K. Lovero, T. Iwanaga, A. Watanabe, N. Yokoi, K. Tabuchi, R. Shigemoto, R. Nicoll, M. Fukata, PNAS 107 (2010) 3799–3804.","mla":"Fukata, Yuko, et al. “Disruption of LGI1-Linked Synaptic Complex Causes Abnormal Synaptic Transmission and Epilepsy.” <i>PNAS</i>, vol. 107, no. 8, National Academy of Sciences, 2010, pp. 3799–804, doi:<a href=\"https://doi.org/10.1073/pnas.0914537107\">10.1073/pnas.0914537107</a>.","apa":"Fukata, Y., Lovero, K., Iwanaga, T., Watanabe, A., Yokoi, N., Tabuchi, K., … Fukata, M. (2010). Disruption of LGI1-linked synaptic complex causes abnormal synaptic transmission and epilepsy. <i>PNAS</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.0914537107\">https://doi.org/10.1073/pnas.0914537107</a>","ama":"Fukata Y, Lovero K, Iwanaga T, et al. Disruption of LGI1-linked synaptic complex causes abnormal synaptic transmission and epilepsy. <i>PNAS</i>. 2010;107(8):3799-3804. doi:<a href=\"https://doi.org/10.1073/pnas.0914537107\">10.1073/pnas.0914537107</a>","ieee":"Y. Fukata <i>et al.</i>, “Disruption of LGI1-linked synaptic complex causes abnormal synaptic transmission and epilepsy,” <i>PNAS</i>, vol. 107, no. 8. National Academy of Sciences, pp. 3799–3804, 2010.","chicago":"Fukata, Yuko, Kathryn Lovero, Tsuyoshi Iwanaga, Atsushi Watanabe, Norihiko Yokoi, Katsuhiko Tabuchi, Ryuichi Shigemoto, Roger Nicoll, and Masaki Fukata. “Disruption of LGI1-Linked Synaptic Complex Causes Abnormal Synaptic Transmission and Epilepsy.” <i>PNAS</i>. National Academy of Sciences, 2010. <a href=\"https://doi.org/10.1073/pnas.0914537107\">https://doi.org/10.1073/pnas.0914537107</a>."},"_id":"2503","publication":"PNAS","volume":107,"title":"Disruption of LGI1-linked synaptic complex causes abnormal synaptic transmission and epilepsy","year":"2010","publication_status":"published","doi":"10.1073/pnas.0914537107"},{"citation":{"ama":"Loukanov A, Kamasawa N, Danev R, Shigemoto R, Nagayama K. Immunolocalization of multiple membrane proteins on a carbon replica with STEM and EDX. <i>Ultramicroscopy</i>. 2010;110(4):366-374. doi:<a href=\"https://doi.org/10.1016/j.ultramic.2010.01.016\">10.1016/j.ultramic.2010.01.016</a>","ieee":"A. Loukanov, N. Kamasawa, R. Danev, R. Shigemoto, and K. Nagayama, “Immunolocalization of multiple membrane proteins on a carbon replica with STEM and EDX,” <i>Ultramicroscopy</i>, vol. 110, no. 4. Elsevier, pp. 366–374, 2010.","chicago":"Loukanov, Alexandre, Naomi Kamasawa, Radostin Danev, Ryuichi Shigemoto, and Kuniaki Nagayama. “Immunolocalization of Multiple Membrane Proteins on a Carbon Replica with STEM and EDX.” <i>Ultramicroscopy</i>. Elsevier, 2010. <a href=\"https://doi.org/10.1016/j.ultramic.2010.01.016\">https://doi.org/10.1016/j.ultramic.2010.01.016</a>.","ista":"Loukanov A, Kamasawa N, Danev R, Shigemoto R, Nagayama K. 2010. Immunolocalization of multiple membrane proteins on a carbon replica with STEM and EDX. Ultramicroscopy. 110(4), 366–374.","short":"A. Loukanov, N. Kamasawa, R. Danev, R. Shigemoto, K. Nagayama, Ultramicroscopy 110 (2010) 366–374.","apa":"Loukanov, A., Kamasawa, N., Danev, R., Shigemoto, R., &#38; Nagayama, K. (2010). Immunolocalization of multiple membrane proteins on a carbon replica with STEM and EDX. <i>Ultramicroscopy</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.ultramic.2010.01.016\">https://doi.org/10.1016/j.ultramic.2010.01.016</a>","mla":"Loukanov, Alexandre, et al. “Immunolocalization of Multiple Membrane Proteins on a Carbon Replica with STEM and EDX.” <i>Ultramicroscopy</i>, vol. 110, no. 4, Elsevier, 2010, pp. 366–74, doi:<a href=\"https://doi.org/10.1016/j.ultramic.2010.01.016\">10.1016/j.ultramic.2010.01.016</a>."},"_id":"2504","publication":"Ultramicroscopy","title":"Immunolocalization of multiple membrane proteins on a carbon replica with STEM and EDX","volume":110,"doi":"10.1016/j.ultramic.2010.01.016","year":"2010","publication_status":"published","page":"366 - 374","month":"03","day":"01","extern":1,"status":"public","type":"journal_article","abstract":[{"text":"We present a method for immunolabeling of multiple species of membrane proteins with high spatial resolution. It allows differentiation of equally sized very small markers with different chemical compositions, which leads to high labeling efficiency and reduces steric hindrance of closely spaced immunolabeled biomolecules. Markers such as CdSe/ZnS semiconductor quantum dots and colloidal gold particles are distinguished by differential contrast in high-angle annular detector dark-field STEM mode or by EDX microanalysis of their elemental contents. This method was tested by observation of labeled AMPA- and NMDA-type glutamate receptors on sodium-dodecyl-sulfate-digested replica prepared from rat hippocampus. To improve particle visibility and detectability, the replica films were made exclusively with carbon to avoid the high background of conventional platinum/carbon replica. Extension of the method is suggested by detection of 1.4 nm nanogold particles and its potential application in the biological imaging research.","lang":"eng"}],"publist_id":"4397","quality_controlled":0,"author":[{"first_name":"Alexandre","full_name":"Loukanov, Alexandre R","last_name":"Loukanov"},{"last_name":"Kamasawa","first_name":"Naomi","full_name":"Kamasawa, Naomi"},{"last_name":"Danev","full_name":"Danev, Radostin S","first_name":"Radostin"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","full_name":"Ryuichi Shigemoto","last_name":"Shigemoto","orcid":"0000-0001-8761-9444"},{"first_name":"Kuniaki","full_name":"Nagayama, Kuniaki","last_name":"Nagayama"}],"publisher":"Elsevier","date_published":"2010-03-01T00:00:00Z","date_updated":"2021-01-12T06:57:53Z","date_created":"2018-12-11T11:58:03Z","intvolume":"       110","issue":"4"},{"citation":{"apa":"Matsuda, K., Miura, E., Miyazaki, T., Kakegawa, W., Emi, K., Narumi, S., … Yuzaki, M. (2010). Cbln1 is a ligand for an orphan glutamate receptor δ2, a bidirectional synapse organizer. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1185152\">https://doi.org/10.1126/science.1185152</a>","mla":"Matsuda, Keiko, et al. “Cbln1 Is a Ligand for an Orphan Glutamate Receptor Δ2, a Bidirectional Synapse Organizer.” <i>Science</i>, vol. 328, no. 5976, American Association for the Advancement of Science, 2010, pp. 363–68, doi:<a href=\"https://doi.org/10.1126/science.1185152\">10.1126/science.1185152</a>.","short":"K. Matsuda, E. Miura, T. Miyazaki, W. Kakegawa, K. Emi, S. Narumi, Y. Fukazawa, A. Ito Lshida, T. Kondo, R. Shigemoto, M. Watanabe, M. Yuzaki, Science 328 (2010) 363–368.","ista":"Matsuda K, Miura E, Miyazaki T, Kakegawa W, Emi K, Narumi S, Fukazawa Y, Ito Lshida A, Kondo T, Shigemoto R, Watanabe M, Yuzaki M. 2010. Cbln1 is a ligand for an orphan glutamate receptor δ2, a bidirectional synapse organizer. Science. 328(5976), 363–368.","chicago":"Matsuda, Keiko, Eriko Miura, Taisuke Miyazaki, Wataru Kakegawa, Kyoichi Emi, Sakae Narumi, Yugo Fukazawa, et al. “Cbln1 Is a Ligand for an Orphan Glutamate Receptor Δ2, a Bidirectional Synapse Organizer.” <i>Science</i>. American Association for the Advancement of Science, 2010. <a href=\"https://doi.org/10.1126/science.1185152\">https://doi.org/10.1126/science.1185152</a>.","ama":"Matsuda K, Miura E, Miyazaki T, et al. Cbln1 is a ligand for an orphan glutamate receptor δ2, a bidirectional synapse organizer. <i>Science</i>. 2010;328(5976):363-368. doi:<a href=\"https://doi.org/10.1126/science.1185152\">10.1126/science.1185152</a>","ieee":"K. Matsuda <i>et al.</i>, “Cbln1 is a ligand for an orphan glutamate receptor δ2, a bidirectional synapse organizer,” <i>Science</i>, vol. 328, no. 5976. American Association for the Advancement of Science, pp. 363–368, 2010."},"_id":"2505","publication":"Science","title":"Cbln1 is a ligand for an orphan glutamate receptor δ2, a bidirectional synapse organizer","volume":328,"doi":"10.1126/science.1185152","publication_status":"published","year":"2010","page":"363 - 368","month":"04","day":"16","extern":1,"status":"public","type":"journal_article","abstract":[{"lang":"eng","text":"Cbln1, secreted from cerebellar granule cells, and the orphan glutamate receptor 52 (GluD2), expressed by Purkinje cells, are essential for synapse integrity between these neurons in adult mice. Nevertheless, no endogenous binding partners for these molecules have been identified. We found that Cblnl binds directly to the N-terminal domain of GluD2. GluD2 expression by postsynaptic cells, combined with exogenously applied Cbln1, was necessary and sufficient to induce new synapses in vitro and in the adult cerebellum in vivo. Further, beads coated with recombinant Cbln1 directly induced presynaptic differentiation and indirectly caused clustering of postsynaptic molecules via GluD2. These results indicate that the Cbln1-GluD2 complex is a unique synapse organizer that acts bidirectionally on both pre- and postsynaptic components."}],"publist_id":"4396","publisher":"American Association for the Advancement of Science","author":[{"full_name":"Matsuda, Keiko","first_name":"Keiko","last_name":"Matsuda"},{"last_name":"Miura","full_name":"Miura, Eriko","first_name":"Eriko"},{"first_name":"Taisuke","full_name":"Miyazaki, Taisuke","last_name":"Miyazaki"},{"last_name":"Kakegawa","full_name":"Kakegawa, Wataru","first_name":"Wataru"},{"last_name":"Emi","full_name":"Emi, Kyoichi","first_name":"Kyoichi"},{"first_name":"Sakae","full_name":"Narumi, Sakae","last_name":"Narumi"},{"last_name":"Fukazawa","full_name":"Fukazawa, Yugo","first_name":"Yugo"},{"last_name":"Ito Lshida","full_name":"Ito-lshida, Aya","first_name":"Aya"},{"full_name":"Kondo, Tetsuro","first_name":"Tetsuro","last_name":"Kondo"},{"first_name":"Ryuichi","full_name":"Ryuichi Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444","last_name":"Shigemoto"},{"last_name":"Watanabe","first_name":"Masahiko","full_name":"Watanabe, Masahiko"},{"last_name":"Yuzaki","first_name":"Michisuke","full_name":"Yuzaki, Michisuke"}],"quality_controlled":0,"date_published":"2010-04-16T00:00:00Z","date_updated":"2021-01-12T06:57:53Z","intvolume":"       328","date_created":"2018-12-11T11:58:04Z","issue":"5976"},{"abstract":[{"text":"Subepithelial fibroblasts of the intestinal villi, which form a contractile cellular network beneath the epithelium, are in close contact with epithelial cells, nerve varicosities, capillaries, smooth muscles and immune cells, and secrete extracellular matrix molecules, growth factors and cytokines, etc. Cultured subepithelial fibroblasts of the rat duodenal villi display various receptors such as endothelins, ATP, substance-P and bradykinin, and release ATP in response to mechanical stimulation. In this study, the presence of functional NK1 receptors (NK1R) was pharmacologically confirmed in primary culture by Ca 2+ measurement, and the effects of substance-P were measured in an acute preparation of epithelium-free duodenal villi from 2- to 3-week-old rats using a two-photon laser microscope. Substance-P elicited an increase in the intracellular Ca 2+ concentration and contraction of the subepithelial fibroblasts in culture and the isolated villi. The localization of NK1R and substance-P in the villi was examined by light and electron microscopic immunohistochemistry. NK1R-like immunoreactivity was intensely localized on the plasma membrane of villous subepithelial fibroblasts in 10-day- to 4-week-old rats and mice and was decreased or absent in adulthood. The pericryptal fibroblasts of the small and large intestine were NK1R immuno-negative. These villous subepithelial fibroblasts form synapse-like structures with both substance-P-immunopositive and -immunonegative nerve varicosities. Here, we propose that the mutual interaction between villous subepithelial fibroblasts and afferent neurons via substance-P and ATP plays important roles in the maturation of the structure and function of the small intestine.","lang":"eng"}],"publist_id":"4395","extern":1,"day":"01","type":"journal_article","status":"public","date_updated":"2021-01-12T06:57:54Z","intvolume":"       342","date_created":"2018-12-11T11:58:04Z","issue":"2","author":[{"last_name":"Furuya","first_name":"Sonoko","full_name":"Furuya, Sonoko"},{"full_name":"Furuya, Kishio","first_name":"Kishio","last_name":"Furuya"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Ryuichi Shigemoto","first_name":"Ryuichi","last_name":"Shigemoto","orcid":"0000-0001-8761-9444"},{"full_name":"Sokabe, Masahiro","first_name":"Masahiro","last_name":"Sokabe"}],"publisher":"Springer","quality_controlled":0,"date_published":"2010-11-01T00:00:00Z","title":"Localization of NK1 receptors and roles of substance-P in subepithelial fibroblasts of rat intestinal villi","_id":"2506","volume":342,"publication":"Cell and Tissue Research","doi":"10.1007/s00441-010-1056-7","year":"2010","publication_status":"published","citation":{"apa":"Furuya, S., Furuya, K., Shigemoto, R., &#38; Sokabe, M. (2010). Localization of NK1 receptors and roles of substance-P in subepithelial fibroblasts of rat intestinal villi. <i>Cell and Tissue Research</i>. Springer. <a href=\"https://doi.org/10.1007/s00441-010-1056-7\">https://doi.org/10.1007/s00441-010-1056-7</a>","mla":"Furuya, Sonoko, et al. “Localization of NK1 Receptors and Roles of Substance-P in Subepithelial Fibroblasts of Rat Intestinal Villi.” <i>Cell and Tissue Research</i>, vol. 342, no. 2, Springer, 2010, pp. 243–59, doi:<a href=\"https://doi.org/10.1007/s00441-010-1056-7\">10.1007/s00441-010-1056-7</a>.","short":"S. Furuya, K. Furuya, R. Shigemoto, M. Sokabe, Cell and Tissue Research 342 (2010) 243–259.","ista":"Furuya S, Furuya K, Shigemoto R, Sokabe M. 2010. Localization of NK1 receptors and roles of substance-P in subepithelial fibroblasts of rat intestinal villi. Cell and Tissue Research. 342(2), 243–259.","chicago":"Furuya, Sonoko, Kishio Furuya, Ryuichi Shigemoto, and Masahiro Sokabe. “Localization of NK1 Receptors and Roles of Substance-P in Subepithelial Fibroblasts of Rat Intestinal Villi.” <i>Cell and Tissue Research</i>. Springer, 2010. <a href=\"https://doi.org/10.1007/s00441-010-1056-7\">https://doi.org/10.1007/s00441-010-1056-7</a>.","ama":"Furuya S, Furuya K, Shigemoto R, Sokabe M. Localization of NK1 receptors and roles of substance-P in subepithelial fibroblasts of rat intestinal villi. <i>Cell and Tissue Research</i>. 2010;342(2):243-259. doi:<a href=\"https://doi.org/10.1007/s00441-010-1056-7\">10.1007/s00441-010-1056-7</a>","ieee":"S. Furuya, K. Furuya, R. Shigemoto, and M. Sokabe, “Localization of NK1 receptors and roles of substance-P in subepithelial fibroblasts of rat intestinal villi,” <i>Cell and Tissue Research</i>, vol. 342, no. 2. Springer, pp. 243–259, 2010."},"month":"11","page":"243 - 259"},{"publist_id":"4394","abstract":[{"text":"T-type calcium channels play a pivotal role in regulating neural membrane excitability in the nervous system. However, the precise subcellular distributions of T-type channel subunits and their implication for membrane excitability are not well understood. Here we investigated the subcellular distribution of the α1G subunit of the calcium channel which is expressed highly in the mouse dorsal lateral geniculate nucleus (dLGN). Light microscopic analysis demonstrated that dLGN exhibits intense immunoperoxidase reactivity for the α1G subunit. Electron microscopic observation showed that the labeling was present in both the relay cells and interneurons and was found in the somatodendritic, but not axonal, domains of these cells. Most of the immunogold particles for the α1G subunit were either associated with the plasma membrane or the intracellular membranes. Reconstruction analysis of serial electron microscopic images revealed that the intensity of the intracellular labeling exhibited a gradient such that the labeling density was higher in the proximal dendrite and progressively decreased towards the distal dendrite. In contrast, the plasma membrane-associated particles were distributed with a uniform density over the somatodendritic surface of dLGN cells. The labeling density in the relay cell plasma membrane was about 3-fold higher than that of the interneurons. These results provide ultrastructural evidence for cell-type-specific expression levels and for uniform expression density of the α1G subunit over the plasma membrane of dLGN cells.","lang":"eng"}],"status":"public","type":"journal_article","day":"01","extern":1,"issue":"21","date_created":"2018-12-11T11:58:04Z","intvolume":"       518","date_updated":"2021-01-12T06:57:54Z","date_published":"2010-11-01T00:00:00Z","author":[{"full_name":"Parajuli, Laxmi K","first_name":"Laxmi","last_name":"Parajuli"},{"full_name":"Fukazawa, Yugo","first_name":"Yugo","last_name":"Fukazawa"},{"first_name":"Masahiko","full_name":"Watanabe, Masahiko","last_name":"Watanabe"},{"orcid":"0000-0001-8761-9444","last_name":"Shigemoto","full_name":"Ryuichi Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi"}],"quality_controlled":0,"publisher":"Wiley-Blackwell","year":"2010","publication_status":"published","doi":"10.1002/cne.22461","volume":518,"_id":"2507","publication":"Journal of Comparative Neurology","title":"Subcellular distribution of α1G subunit of T-type calcium channel in the mouse dorsal lateral geniculate nucleus","citation":{"short":"L. Parajuli, Y. Fukazawa, M. Watanabe, R. Shigemoto, Journal of Comparative Neurology 518 (2010) 4362–4374.","ista":"Parajuli L, Fukazawa Y, Watanabe M, Shigemoto R. 2010. Subcellular distribution of α1G subunit of T-type calcium channel in the mouse dorsal lateral geniculate nucleus. Journal of Comparative Neurology. 518(21), 4362–4374.","apa":"Parajuli, L., Fukazawa, Y., Watanabe, M., &#38; Shigemoto, R. (2010). Subcellular distribution of α1G subunit of T-type calcium channel in the mouse dorsal lateral geniculate nucleus. <i>Journal of Comparative Neurology</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1002/cne.22461\">https://doi.org/10.1002/cne.22461</a>","mla":"Parajuli, Laxmi, et al. “Subcellular Distribution of Α1G Subunit of T-Type Calcium Channel in the Mouse Dorsal Lateral Geniculate Nucleus.” <i>Journal of Comparative Neurology</i>, vol. 518, no. 21, Wiley-Blackwell, 2010, pp. 4362–74, doi:<a href=\"https://doi.org/10.1002/cne.22461\">10.1002/cne.22461</a>.","ieee":"L. Parajuli, Y. Fukazawa, M. Watanabe, and R. Shigemoto, “Subcellular distribution of α1G subunit of T-type calcium channel in the mouse dorsal lateral geniculate nucleus,” <i>Journal of Comparative Neurology</i>, vol. 518, no. 21. Wiley-Blackwell, pp. 4362–4374, 2010.","ama":"Parajuli L, Fukazawa Y, Watanabe M, Shigemoto R. Subcellular distribution of α1G subunit of T-type calcium channel in the mouse dorsal lateral geniculate nucleus. <i>Journal of Comparative Neurology</i>. 2010;518(21):4362-4374. doi:<a href=\"https://doi.org/10.1002/cne.22461\">10.1002/cne.22461</a>","chicago":"Parajuli, Laxmi, Yugo Fukazawa, Masahiko Watanabe, and Ryuichi Shigemoto. “Subcellular Distribution of Α1G Subunit of T-Type Calcium Channel in the Mouse Dorsal Lateral Geniculate Nucleus.” <i>Journal of Comparative Neurology</i>. Wiley-Blackwell, 2010. <a href=\"https://doi.org/10.1002/cne.22461\">https://doi.org/10.1002/cne.22461</a>."},"month":"11","page":"4362 - 4374"},{"date_updated":"2021-01-12T06:57:54Z","intvolume":"        30","date_created":"2018-12-11T11:58:05Z","issue":"47","quality_controlled":0,"publisher":"Society for Neuroscience","author":[{"first_name":"Jeremy","full_name":"Atherton, Jeremy F","last_name":"Atherton"},{"last_name":"Kitano","full_name":"Kitano, Katsunori","first_name":"Katsunori"},{"last_name":"Baufreton","full_name":"Baufreton, Jérôme","first_name":"Jérôme"},{"last_name":"Fan","full_name":"Fan, Kai","first_name":"Kai"},{"first_name":"David","full_name":"Wokosin, David L","last_name":"Wokosin"},{"last_name":"Tkatch","full_name":"Tkatch, Tatiana","first_name":"Tatiana"},{"first_name":"Ryuichi","full_name":"Ryuichi Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","orcid":"0000-0001-8761-9444"},{"last_name":"Surmeier","first_name":"James","full_name":"Surmeier, James D"},{"last_name":"Bevan","first_name":"Mark","full_name":"Bevan, Mark D"}],"date_published":"2010-11-24T00:00:00Z","abstract":[{"text":"The activity patterns of subthalamic nucleus (STN) neurons are intimately linked to motor function and dysfunction and arise through the complex interaction of intrinsic properties and inhibitory and excitatory synaptic inputs. In many neurons, hyperpolarization-activated cyclic nucleotide-gated (HCN) channels play key roles in intrinsic excitability and synaptic integration both under normal conditions and in disease states. However, in STN neurons, which strongly express HCN channels, their roles remain relatively obscure. To address this deficit, complementary molecular and cellular electrophysiological, imaging, and computational approaches were applied to the rat STN. Molecular profiling demonstrated that individual STN neurons express mRNA encoding several HCN subunits, with HCN2 and 3 being the most abundant. Light and electron microscopic analysis showed that HCN2 subunits are strongly expressed and distributed throughout the somatodendritic plasma membrane. Voltage-, current-, and dynamic-clamp analysis, two-photon Ca 2+ imaging, and computational modeling revealed that HCN channels are activated by GABA A receptor-mediated inputs and thus limit synaptic hyperpolarization and deinactivation of low-voltage-activated Ca 2+ channels. Although HCN channels also limited the temporal summation of EPSPs, generated through two-photon uncaging of glutamate, this action was largely shunted by GABAergic inhibition that was necessary for HCN channel activation. Together the data demonstrate that HCN channels in STN neurons selectively counteract GABA A receptor-mediated inhibition arising from the globus pallidus and thus promote single-spike activity rather than rebound burst firing. ","lang":"eng"}],"publist_id":"4393","day":"24","extern":1,"status":"public","type":"journal_article","month":"11","page":"16025 - 16040","publication":"Journal of Neuroscience","_id":"2508","volume":30,"title":"Selective participation of somatodendritic HCN channels in inhibitory but not excitatory synaptic integration in neurons of the subthalamic nucleus","doi":"10.1523/JNEUROSCI.3898-10.2010","publication_status":"published","year":"2010","citation":{"ieee":"J. Atherton <i>et al.</i>, “Selective participation of somatodendritic HCN channels in inhibitory but not excitatory synaptic integration in neurons of the subthalamic nucleus,” <i>Journal of Neuroscience</i>, vol. 30, no. 47. Society for Neuroscience, pp. 16025–16040, 2010.","ama":"Atherton J, Kitano K, Baufreton J, et al. Selective participation of somatodendritic HCN channels in inhibitory but not excitatory synaptic integration in neurons of the subthalamic nucleus. <i>Journal of Neuroscience</i>. 2010;30(47):16025-16040. doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.3898-10.2010\">10.1523/JNEUROSCI.3898-10.2010</a>","chicago":"Atherton, Jeremy, Katsunori Kitano, Jérôme Baufreton, Kai Fan, David Wokosin, Tatiana Tkatch, Ryuichi Shigemoto, James Surmeier, and Mark Bevan. “Selective Participation of Somatodendritic HCN Channels in Inhibitory but Not Excitatory Synaptic Integration in Neurons of the Subthalamic Nucleus.” <i>Journal of Neuroscience</i>. Society for Neuroscience, 2010. <a href=\"https://doi.org/10.1523/JNEUROSCI.3898-10.2010\">https://doi.org/10.1523/JNEUROSCI.3898-10.2010</a>.","apa":"Atherton, J., Kitano, K., Baufreton, J., Fan, K., Wokosin, D., Tkatch, T., … Bevan, M. (2010). Selective participation of somatodendritic HCN channels in inhibitory but not excitatory synaptic integration in neurons of the subthalamic nucleus. <i>Journal of Neuroscience</i>. Society for Neuroscience. <a href=\"https://doi.org/10.1523/JNEUROSCI.3898-10.2010\">https://doi.org/10.1523/JNEUROSCI.3898-10.2010</a>","mla":"Atherton, Jeremy, et al. “Selective Participation of Somatodendritic HCN Channels in Inhibitory but Not Excitatory Synaptic Integration in Neurons of the Subthalamic Nucleus.” <i>Journal of Neuroscience</i>, vol. 30, no. 47, Society for Neuroscience, 2010, pp. 16025–40, doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.3898-10.2010\">10.1523/JNEUROSCI.3898-10.2010</a>.","ista":"Atherton J, Kitano K, Baufreton J, Fan K, Wokosin D, Tkatch T, Shigemoto R, Surmeier J, Bevan M. 2010. Selective participation of somatodendritic HCN channels in inhibitory but not excitatory synaptic integration in neurons of the subthalamic nucleus. Journal of Neuroscience. 30(47), 16025–16040.","short":"J. Atherton, K. Kitano, J. Baufreton, K. Fan, D. Wokosin, T. Tkatch, R. Shigemoto, J. Surmeier, M. Bevan, Journal of Neuroscience 30 (2010) 16025–16040."}},{"type":"journal_article","status":"public","day":"14","extern":1,"publist_id":"4392","abstract":[{"text":"Hippocampal CA1 pyramidal cells, which receive γ-aminobutyric acid (GABA)ergic input from at least 18 types of presynaptic neuron, express 14 subunits of the pentameric GABAA receptor. The relative contribution of any subunit to synaptic and extrasynaptic receptors influences the dynamics of GABA and drug actions. Synaptic receptors mediate phasic GABA-evoked conductance and extrasynaptic receptors contribute to a tonic conductance. We used freeze-fracture replica-immunogold labelling, a sensitive quantitative immunocytochemical method, to detect synaptic and extrasynaptic pools of the alpha1, alpha2 and beta3 subunits. Antibodies to the cytoplasmic loop of the subunits showed immunogold particles concentrated on distinct clusters of intramembrane particles (IMPs) on the cytoplasmic face of the plasma membrane on the somata, dendrites and axon initial segments, with an abrupt decrease in labelling at the edge of the IMP cluster. Neuroligin-2, a GABAergic synapse-specific adhesion molecule, co-labels all beta3 subunit-rich IMP clusters, therefore we considered them synapses. Double-labelling for two subunits showed that virtually all somatic synapses contain the alpha1, alpha2 and beta3 subunits. The extrasynaptic plasma membrane of the somata, dendrites and dendritic spines showed low-density immunolabelling. Synaptic labelling densities on somata for the alpha1, alpha2 and beta3 subunits were 78-132, 94 and 79 times higher than on the extrasynaptic membranes, respectively. As GABAergic synapses occupy 0.72% of the soma surface, the fraction of synaptic labelling was 33-48 (alpha1), 40 (alpha2) and 36 (beta3)% of the total somatic surface immunolabelling. Assuming similar antibody access to all receptors, about 60% of these subunits are in extrasynaptic receptors.","lang":"eng"}],"date_published":"2010-11-14T00:00:00Z","quality_controlled":0,"publisher":"Wiley-Blackwell","author":[{"full_name":"Kasugai, Yu","first_name":"Yu","last_name":"Kasugai"},{"full_name":"Swinny, Jerome D","first_name":"Jerome","last_name":"Swinny"},{"last_name":"Roberts","full_name":"Roberts, John D","first_name":"John"},{"first_name":"Yannis","full_name":"Dalezios, Yannis","last_name":"Dalezios"},{"first_name":"Yugo","full_name":"Fukazawa, Yugo","last_name":"Fukazawa"},{"first_name":"Werner","full_name":"Sieghart, Werner C","last_name":"Sieghart"},{"last_name":"Shigemoto","orcid":"0000-0001-8761-9444","first_name":"Ryuichi","full_name":"Ryuichi Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Somogyi, Péter","first_name":"Péter","last_name":"Somogyi"}],"issue":"11","date_updated":"2021-01-12T06:57:55Z","date_created":"2018-12-11T11:58:05Z","intvolume":"        32","citation":{"apa":"Kasugai, Y., Swinny, J., Roberts, J., Dalezios, Y., Fukazawa, Y., Sieghart, W., … Somogyi, P. (2010). Quantitative localisation of synaptic and extrasynaptic GABAA receptor subunits on hippocampal pyramidal cells by freeze-fracture replica immunolabelling. <i>European Journal of Neuroscience</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1111/j.1460-9568.2010.07473.x\">https://doi.org/10.1111/j.1460-9568.2010.07473.x</a>","mla":"Kasugai, Yu, et al. “Quantitative Localisation of Synaptic and Extrasynaptic GABAA Receptor Subunits on Hippocampal Pyramidal Cells by Freeze-Fracture Replica Immunolabelling.” <i>European Journal of Neuroscience</i>, vol. 32, no. 11, Wiley-Blackwell, 2010, pp. 1868–88, doi:<a href=\"https://doi.org/10.1111/j.1460-9568.2010.07473.x\">10.1111/j.1460-9568.2010.07473.x</a>.","ista":"Kasugai Y, Swinny J, Roberts J, Dalezios Y, Fukazawa Y, Sieghart W, Shigemoto R, Somogyi P. 2010. Quantitative localisation of synaptic and extrasynaptic GABAA receptor subunits on hippocampal pyramidal cells by freeze-fracture replica immunolabelling. European Journal of Neuroscience. 32(11), 1868–1888.","short":"Y. Kasugai, J. Swinny, J. Roberts, Y. Dalezios, Y. Fukazawa, W. Sieghart, R. Shigemoto, P. Somogyi, European Journal of Neuroscience 32 (2010) 1868–1888.","ieee":"Y. Kasugai <i>et al.</i>, “Quantitative localisation of synaptic and extrasynaptic GABAA receptor subunits on hippocampal pyramidal cells by freeze-fracture replica immunolabelling,” <i>European Journal of Neuroscience</i>, vol. 32, no. 11. Wiley-Blackwell, pp. 1868–1888, 2010.","ama":"Kasugai Y, Swinny J, Roberts J, et al. Quantitative localisation of synaptic and extrasynaptic GABAA receptor subunits on hippocampal pyramidal cells by freeze-fracture replica immunolabelling. <i>European Journal of Neuroscience</i>. 2010;32(11):1868-1888. doi:<a href=\"https://doi.org/10.1111/j.1460-9568.2010.07473.x\">10.1111/j.1460-9568.2010.07473.x</a>","chicago":"Kasugai, Yu, Jerome Swinny, John Roberts, Yannis Dalezios, Yugo Fukazawa, Werner Sieghart, Ryuichi Shigemoto, and Péter Somogyi. “Quantitative Localisation of Synaptic and Extrasynaptic GABAA Receptor Subunits on Hippocampal Pyramidal Cells by Freeze-Fracture Replica Immunolabelling.” <i>European Journal of Neuroscience</i>. Wiley-Blackwell, 2010. <a href=\"https://doi.org/10.1111/j.1460-9568.2010.07473.x\">https://doi.org/10.1111/j.1460-9568.2010.07473.x</a>."},"doi":"10.1111/j.1460-9568.2010.07473.x","year":"2010","publication_status":"published","volume":32,"_id":"2509","publication":"European Journal of Neuroscience","title":"Quantitative localisation of synaptic and extrasynaptic GABAA receptor subunits on hippocampal pyramidal cells by freeze-fracture replica immunolabelling","page":"1868 - 1888","month":"11"}]