[{"month":"12","extern":"1","day":"01","publication_status":"published","publication_identifier":{"issn":["0955-0674"]},"pmid":1,"status":"public","abstract":[{"lang":"eng","text":"The Nuclear Envelope (NE) contains over 100 different proteins that associate with nuclear components such as chromatin, the lamina and the transcription machinery. Mutations in genes encoding NE proteins have been shown to result in tissue-specific defects and disease, suggesting cell-type specific differences in NE composition and function. Consistent with these observations, recent studies have revealed unexpected functions for numerous NE associated proteins during cell differentiation and development. Here we review the latest insights into the roles played by the NE in cell differentiation, development, disease and aging, focusing primarily on inner nuclear membrane (INM) proteins and nuclear pore components."}],"doi":"10.1016/j.ceb.2012.08.008","issue":"6","article_type":"original","page":"775-783","intvolume":"        24","language":[{"iso":"eng"}],"publisher":"Elsevier","type":"journal_article","author":[{"last_name":"Gomez-Cavazos","full_name":"Gomez-Cavazos, J Sebastian","first_name":"J Sebastian"},{"last_name":"HETZER","first_name":"Martin W","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","full_name":"HETZER, Martin W","orcid":"0000-0002-2111-992X"}],"user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","citation":{"ieee":"J. S. Gomez-Cavazos and M. Hetzer, “Outfits for different occasions: tissue-specific roles of Nuclear Envelope proteins,” <i>Current Opinion in Cell Biology</i>, vol. 24, no. 6. Elsevier, pp. 775–783, 2012.","ama":"Gomez-Cavazos JS, Hetzer M. Outfits for different occasions: tissue-specific roles of Nuclear Envelope proteins. <i>Current Opinion in Cell Biology</i>. 2012;24(6):775-783. doi:<a href=\"https://doi.org/10.1016/j.ceb.2012.08.008\">10.1016/j.ceb.2012.08.008</a>","short":"J.S. Gomez-Cavazos, M. Hetzer, Current Opinion in Cell Biology 24 (2012) 775–783.","chicago":"Gomez-Cavazos, J Sebastian, and Martin Hetzer. “Outfits for Different Occasions: Tissue-Specific Roles of Nuclear Envelope Proteins.” <i>Current Opinion in Cell Biology</i>. Elsevier, 2012. <a href=\"https://doi.org/10.1016/j.ceb.2012.08.008\">https://doi.org/10.1016/j.ceb.2012.08.008</a>.","ista":"Gomez-Cavazos JS, Hetzer M. 2012. Outfits for different occasions: tissue-specific roles of Nuclear Envelope proteins. Current Opinion in Cell Biology. 24(6), 775–783.","mla":"Gomez-Cavazos, J. Sebastian, and Martin Hetzer. “Outfits for Different Occasions: Tissue-Specific Roles of Nuclear Envelope Proteins.” <i>Current Opinion in Cell Biology</i>, vol. 24, no. 6, Elsevier, 2012, pp. 775–83, doi:<a href=\"https://doi.org/10.1016/j.ceb.2012.08.008\">10.1016/j.ceb.2012.08.008</a>.","apa":"Gomez-Cavazos, J. S., &#38; Hetzer, M. (2012). Outfits for different occasions: tissue-specific roles of Nuclear Envelope proteins. <i>Current Opinion in Cell Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.ceb.2012.08.008\">https://doi.org/10.1016/j.ceb.2012.08.008</a>"},"oa_version":"None","date_updated":"2022-07-18T08:38:47Z","_id":"11089","scopus_import":"1","external_id":{"pmid":["22995343"]},"date_created":"2022-04-07T07:51:37Z","volume":24,"article_processing_charge":"No","publication":"Current Opinion in Cell Biology","year":"2012","quality_controlled":"1","keyword":["Cell Biology"],"date_published":"2012-12-01T00:00:00Z","title":"Outfits for different occasions: tissue-specific roles of Nuclear Envelope proteins"},{"doi":"10.1016/j.cell.2012.04.018","abstract":[{"text":"Nuclear export of mRNAs is thought to occur exclusively through nuclear pore complexes. In this issue of Cell, Speese et al. identify an alternate pathway for mRNA export in muscle cells where ribonucleoprotein complexes involved in forming neuromuscular junctions transit the nuclear envelope by fusing with and budding through the nuclear membrane.","lang":"eng"}],"issue":"4","publication_identifier":{"issn":["0092-8674"]},"status":"public","pmid":1,"extern":"1","day":"11","publication_status":"published","month":"05","publisher":"Elsevier","language":[{"iso":"eng"}],"article_type":"letter_note","page":"733-735","intvolume":"       149","scopus_import":"1","external_id":{"pmid":["22579277"]},"_id":"11090","author":[{"first_name":"Emily M.","full_name":"Hatch, Emily M.","last_name":"Hatch"},{"orcid":"0000-0002-2111-992X","full_name":"HETZER, Martin W","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","first_name":"Martin W","last_name":"HETZER"}],"oa":1,"citation":{"mla":"Hatch, Emily M., and Martin Hetzer. “RNP Export by Nuclear Envelope Budding.” <i>Cell</i>, vol. 149, no. 4, Elsevier, 2012, pp. 733–35, doi:<a href=\"https://doi.org/10.1016/j.cell.2012.04.018\">10.1016/j.cell.2012.04.018</a>.","apa":"Hatch, E. M., &#38; Hetzer, M. (2012). RNP export by nuclear envelope budding. <i>Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cell.2012.04.018\">https://doi.org/10.1016/j.cell.2012.04.018</a>","ista":"Hatch EM, Hetzer M. 2012. RNP export by nuclear envelope budding. Cell. 149(4), 733–735.","ieee":"E. M. Hatch and M. Hetzer, “RNP export by nuclear envelope budding,” <i>Cell</i>, vol. 149, no. 4. Elsevier, pp. 733–735, 2012.","chicago":"Hatch, Emily M., and Martin Hetzer. “RNP Export by Nuclear Envelope Budding.” <i>Cell</i>. Elsevier, 2012. <a href=\"https://doi.org/10.1016/j.cell.2012.04.018\">https://doi.org/10.1016/j.cell.2012.04.018</a>.","ama":"Hatch EM, Hetzer M. RNP export by nuclear envelope budding. <i>Cell</i>. 2012;149(4):733-735. doi:<a href=\"https://doi.org/10.1016/j.cell.2012.04.018\">10.1016/j.cell.2012.04.018</a>","short":"E.M. Hatch, M. Hetzer, Cell 149 (2012) 733–735."},"user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","oa_version":"Published Version","date_updated":"2022-07-18T08:58:48Z","type":"journal_article","quality_controlled":"1","keyword":["General Biochemistry","Genetics and Molecular Biology"],"title":"RNP export by nuclear envelope budding","date_published":"2012-05-11T00:00:00Z","volume":149,"article_processing_charge":"No","publication":"Cell","main_file_link":[{"url":"https://doi.org/10.1016/j.cell.2012.04.018","open_access":"1"}],"year":"2012","date_created":"2022-04-07T07:51:45Z"},{"month":"01","publication_status":"published","extern":"1","day":"01","status":"public","pmid":1,"publication_identifier":{"eissn":["1949-1042"],"issn":["1949-1034"]},"issue":"1","doi":"10.4161/nucl.18954","abstract":[{"text":"Neoplastic cells are often characterized by specific morphological abnormalities of the nuclear envelope (NE), which have been used for cancer diagnosis for more than a century. The NE is a double phospholipid bilayer that encapsulates the nuclear genome, regulates all nuclear trafficking of RNAs and proteins and prevents the passive diffusion of macromolecules between the nucleoplasm and the cytoplasm. Whether there is a consequence to the proper functioning of the cell and loss of structural integrity of the nucleus remains unclear. Using live cell imaging, we characterize a phenomenon wherein nuclei of several proliferating human cancer cell lines become temporarily ruptured during interphase. Strikingly, NE rupturing was associated with the mislocalization of nucleoplasmic and cytoplasmic proteins and, in the most extreme cases, the entrapment of cytoplasmic organelles in the nuclear interior. In addition, we observed the formation of micronuclei-like structures during interphase and the movement of chromatin out of the nuclear space. The frequency of these NE rupturing events was higher in cells in which the nuclear lamina, a network of intermediate filaments providing mechanical support to the NE, was not properly formed. Our data uncover the existence of a NE instability that has the potential to change the genomic landscape of cancer cells.","lang":"eng"}],"intvolume":"         3","article_type":"original","page":"88-100","language":[{"iso":"eng"}],"publisher":"Taylor & Francis","type":"journal_article","oa_version":"None","date_updated":"2022-07-18T08:52:53Z","author":[{"full_name":"Vargas, Jesse D.","first_name":"Jesse D.","last_name":"Vargas"},{"last_name":"Hatch","full_name":"Hatch, Emily M.","first_name":"Emily M."},{"last_name":"Anderson","first_name":"Daniel J.","full_name":"Anderson, Daniel J."},{"last_name":"HETZER","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","full_name":"HETZER, Martin W","first_name":"Martin W","orcid":"0000-0002-2111-992X"}],"citation":{"ista":"Vargas JD, Hatch EM, Anderson DJ, Hetzer M. 2012. Transient nuclear envelope rupturing during interphase in human cancer cells. Nucleus. 3(1), 88–100.","apa":"Vargas, J. D., Hatch, E. M., Anderson, D. J., &#38; Hetzer, M. (2012). Transient nuclear envelope rupturing during interphase in human cancer cells. <i>Nucleus</i>. Taylor &#38; Francis. <a href=\"https://doi.org/10.4161/nucl.18954\">https://doi.org/10.4161/nucl.18954</a>","mla":"Vargas, Jesse D., et al. “Transient Nuclear Envelope Rupturing during Interphase in Human Cancer Cells.” <i>Nucleus</i>, vol. 3, no. 1, Taylor &#38; Francis, 2012, pp. 88–100, doi:<a href=\"https://doi.org/10.4161/nucl.18954\">10.4161/nucl.18954</a>.","ieee":"J. D. Vargas, E. M. Hatch, D. J. Anderson, and M. Hetzer, “Transient nuclear envelope rupturing during interphase in human cancer cells,” <i>Nucleus</i>, vol. 3, no. 1. Taylor &#38; Francis, pp. 88–100, 2012.","short":"J.D. Vargas, E.M. Hatch, D.J. Anderson, M. Hetzer, Nucleus 3 (2012) 88–100.","ama":"Vargas JD, Hatch EM, Anderson DJ, Hetzer M. Transient nuclear envelope rupturing during interphase in human cancer cells. <i>Nucleus</i>. 2012;3(1):88-100. doi:<a href=\"https://doi.org/10.4161/nucl.18954\">10.4161/nucl.18954</a>","chicago":"Vargas, Jesse D., Emily M. Hatch, Daniel J. Anderson, and Martin Hetzer. “Transient Nuclear Envelope Rupturing during Interphase in Human Cancer Cells.” <i>Nucleus</i>. Taylor &#38; Francis, 2012. <a href=\"https://doi.org/10.4161/nucl.18954\">https://doi.org/10.4161/nucl.18954</a>."},"user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","_id":"11091","external_id":{"pmid":["22567193"]},"scopus_import":"1","date_created":"2022-04-07T07:51:53Z","year":"2012","article_processing_charge":"No","volume":3,"publication":"Nucleus","title":"Transient nuclear envelope rupturing during interphase in human cancer cells","keyword":["Cell Biology"],"date_published":"2012-01-01T00:00:00Z","quality_controlled":"1"},{"intvolume":"       335","page":"942-942","article_type":"letter_note","language":[{"iso":"eng"}],"publisher":"American Association for the Advancement of Science","month":"02","publication_status":"published","day":"02","extern":"1","pmid":1,"status":"public","publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"issue":"6071","abstract":[{"text":"To combat the functional decline of the proteome, cells use the process of protein turnover to replace potentially impaired polypeptides with new functional copies. We found that extremely long-lived proteins (ELLPs) did not turn over in postmitotic cells of the rat central nervous system. These ELLPs were associated with chromatin and the nuclear pore complex, the central transport channels that mediate all molecular trafficking in and out of the nucleus. The longevity of these proteins would be expected to expose them to potentially harmful metabolites, putting them at risk of accumulating damage over extended periods of time. Thus, it is possible that failure to maintain proper levels and functional integrity of ELLPs in nonproliferative cells might contribute to age-related deterioration in cell and tissue function.","lang":"eng"}],"doi":"10.1126/science.1217421","date_created":"2022-04-07T07:52:01Z","year":"2012","publication":"Science","article_processing_charge":"No","volume":335,"keyword":["Multidisciplinary"],"title":"Extremely long-lived nuclear pore proteins in the rat brain","date_published":"2012-02-02T00:00:00Z","quality_controlled":"1","type":"journal_article","date_updated":"2022-07-18T08:53:06Z","oa_version":"None","citation":{"ista":"Savas JN, Toyama BH, Xu T, Yates JR, Hetzer M. 2012. Extremely long-lived nuclear pore proteins in the rat brain. Science. 335(6071), 942–942.","mla":"Savas, Jeffrey N., et al. “Extremely Long-Lived Nuclear Pore Proteins in the Rat Brain.” <i>Science</i>, vol. 335, no. 6071, American Association for the Advancement of Science, 2012, pp. 942–942, doi:<a href=\"https://doi.org/10.1126/science.1217421\">10.1126/science.1217421</a>.","apa":"Savas, J. N., Toyama, B. H., Xu, T., Yates, J. R., &#38; Hetzer, M. (2012). Extremely long-lived nuclear pore proteins in the rat brain. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1217421\">https://doi.org/10.1126/science.1217421</a>","ama":"Savas JN, Toyama BH, Xu T, Yates JR, Hetzer M. Extremely long-lived nuclear pore proteins in the rat brain. <i>Science</i>. 2012;335(6071):942-942. doi:<a href=\"https://doi.org/10.1126/science.1217421\">10.1126/science.1217421</a>","short":"J.N. Savas, B.H. Toyama, T. Xu, J.R. Yates, M. Hetzer, Science 335 (2012) 942–942.","chicago":"Savas, Jeffrey N., Brandon H. Toyama, Tao Xu, John R. Yates, and Martin Hetzer. “Extremely Long-Lived Nuclear Pore Proteins in the Rat Brain.” <i>Science</i>. American Association for the Advancement of Science, 2012. <a href=\"https://doi.org/10.1126/science.1217421\">https://doi.org/10.1126/science.1217421</a>.","ieee":"J. N. Savas, B. H. Toyama, T. Xu, J. R. Yates, and M. Hetzer, “Extremely long-lived nuclear pore proteins in the rat brain,” <i>Science</i>, vol. 335, no. 6071. American Association for the Advancement of Science, pp. 942–942, 2012."},"user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","author":[{"first_name":"Jeffrey N.","full_name":"Savas, Jeffrey N.","last_name":"Savas"},{"full_name":"Toyama, Brandon H.","first_name":"Brandon H.","last_name":"Toyama"},{"full_name":"Xu, Tao","first_name":"Tao","last_name":"Xu"},{"last_name":"Yates","first_name":"John R.","full_name":"Yates, John R."},{"last_name":"HETZER","full_name":"HETZER, Martin W","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","first_name":"Martin W","orcid":"0000-0002-2111-992X"}],"_id":"11092","external_id":{"pmid":["22300851"]},"scopus_import":"1"},{"language":[{"iso":"eng"}],"article_type":"original","page":"446-458","intvolume":"        22","publisher":"Elsevier","day":"19","extern":"1","publication_status":"published","month":"01","abstract":[{"text":"Nuclear pore complexes (NPCs) are built from ∼30 different proteins called nucleoporins or Nups. Previous studies have shown that several Nups exhibit cell-type-specific expression and that mutations in NPC components result in tissue-specific diseases. Here we show that a specific change in NPC composition is required for both myogenic and neuronal differentiation. The transmembrane nucleoporin Nup210 is absent in proliferating myoblasts and embryonic stem cells (ESCs) but becomes expressed and incorporated into NPCs during cell differentiation. Preventing Nup210 production by RNAi blocks myogenesis and the differentiation of ESCs into neuroprogenitors. We found that the addition of Nup210 to NPCs does not affect nuclear transport but is required for the induction of genes that are essential for cell differentiation. Our results identify a single change in NPC composition as an essential step in cell differentiation and establish a role for Nup210 in gene expression regulation and cell fate determination.","lang":"eng"}],"doi":"10.1016/j.devcel.2011.11.021","issue":"2","publication_identifier":{"issn":["1534-5807"]},"status":"public","pmid":1,"publication":"Developmental Cell","volume":22,"article_processing_charge":"No","year":"2012","main_file_link":[{"url":"https://doi.org/10.1016/j.devcel.2011.11.021","open_access":"1"}],"date_created":"2022-04-07T07:52:10Z","quality_controlled":"1","title":"A change in nuclear pore complex composition regulates cell differentiation","date_published":"2012-01-19T00:00:00Z","keyword":["Developmental Biology","Cell Biology","General Biochemistry","Genetics and Molecular Biology","Molecular Biology"],"user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","citation":{"apa":"D’Angelo, M. A., Gomez-Cavazos, J. S., Mei, A., Lackner, D. H., &#38; Hetzer, M. (2012). A change in nuclear pore complex composition regulates cell differentiation. <i>Developmental Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.devcel.2011.11.021\">https://doi.org/10.1016/j.devcel.2011.11.021</a>","mla":"D’Angelo, Maximiliano A., et al. “A Change in Nuclear Pore Complex Composition Regulates Cell Differentiation.” <i>Developmental Cell</i>, vol. 22, no. 2, Elsevier, 2012, pp. 446–58, doi:<a href=\"https://doi.org/10.1016/j.devcel.2011.11.021\">10.1016/j.devcel.2011.11.021</a>.","ista":"D’Angelo MA, Gomez-Cavazos JS, Mei A, Lackner DH, Hetzer M. 2012. A change in nuclear pore complex composition regulates cell differentiation. Developmental Cell. 22(2), 446–458.","ieee":"M. A. D’Angelo, J. S. Gomez-Cavazos, A. Mei, D. H. Lackner, and M. Hetzer, “A change in nuclear pore complex composition regulates cell differentiation,” <i>Developmental Cell</i>, vol. 22, no. 2. Elsevier, pp. 446–458, 2012.","chicago":"D’Angelo, Maximiliano A., J. Sebastian Gomez-Cavazos, Arianna Mei, Daniel H. Lackner, and Martin Hetzer. “A Change in Nuclear Pore Complex Composition Regulates Cell Differentiation.” <i>Developmental Cell</i>. Elsevier, 2012. <a href=\"https://doi.org/10.1016/j.devcel.2011.11.021\">https://doi.org/10.1016/j.devcel.2011.11.021</a>.","ama":"D’Angelo MA, Gomez-Cavazos JS, Mei A, Lackner DH, Hetzer M. A change in nuclear pore complex composition regulates cell differentiation. <i>Developmental Cell</i>. 2012;22(2):446-458. doi:<a href=\"https://doi.org/10.1016/j.devcel.2011.11.021\">10.1016/j.devcel.2011.11.021</a>","short":"M.A. D’Angelo, J.S. Gomez-Cavazos, A. Mei, D.H. Lackner, M. Hetzer, Developmental Cell 22 (2012) 446–458."},"oa":1,"author":[{"full_name":"D'Angelo, Maximiliano A.","first_name":"Maximiliano A.","last_name":"D'Angelo"},{"first_name":"J. Sebastian","full_name":"Gomez-Cavazos, J. Sebastian","last_name":"Gomez-Cavazos"},{"full_name":"Mei, Arianna","first_name":"Arianna","last_name":"Mei"},{"full_name":"Lackner, Daniel H.","first_name":"Daniel H.","last_name":"Lackner"},{"last_name":"HETZER","first_name":"Martin W","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","full_name":"HETZER, Martin W","orcid":"0000-0002-2111-992X"}],"date_updated":"2022-07-18T08:53:16Z","oa_version":"Published Version","type":"journal_article","scopus_import":"1","external_id":{"pmid":["22264802"]},"_id":"11093"},{"language":[{"iso":"eng"}],"volume":487,"publication":"Nature","year":"2012","page":"205 - 209","intvolume":"       487","date_created":"2018-12-11T11:44:42Z","date_published":"2012-07-12T00:00:00Z","title":"Impact-activated solidification of dense suspensions via dynamic jamming fronts","publisher":"Nature Publishing Group","author":[{"id":"3A1FFC16-F248-11E8-B48F-1D18A9856A87","full_name":"Waitukaitis, Scott R","first_name":"Scott R","orcid":"0000-0002-2299-3176","last_name":"Waitukaitis"},{"first_name":"Heinrich","full_name":"Jaeger, Heinrich","last_name":"Jaeger"}],"extern":"1","citation":{"ieee":"S. R. Waitukaitis and H. Jaeger, “Impact-activated solidification of dense suspensions via dynamic jamming fronts,” <i>Nature</i>, vol. 487, no. 7406. Nature Publishing Group, pp. 205–209, 2012.","chicago":"Waitukaitis, Scott R, and Heinrich Jaeger. “Impact-Activated Solidification of Dense Suspensions via Dynamic Jamming Fronts.” <i>Nature</i>. Nature Publishing Group, 2012. <a href=\"https://doi.org/10.1038/nature11187\">https://doi.org/10.1038/nature11187</a>.","ama":"Waitukaitis SR, Jaeger H. Impact-activated solidification of dense suspensions via dynamic jamming fronts. <i>Nature</i>. 2012;487(7406):205-209. doi:<a href=\"https://doi.org/10.1038/nature11187\">10.1038/nature11187</a>","short":"S.R. Waitukaitis, H. Jaeger, Nature 487 (2012) 205–209.","apa":"Waitukaitis, S. R., &#38; Jaeger, H. (2012). Impact-activated solidification of dense suspensions via dynamic jamming fronts. <i>Nature</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/nature11187\">https://doi.org/10.1038/nature11187</a>","mla":"Waitukaitis, Scott R., and Heinrich Jaeger. “Impact-Activated Solidification of Dense Suspensions via Dynamic Jamming Fronts.” <i>Nature</i>, vol. 487, no. 7406, Nature Publishing Group, 2012, pp. 205–09, doi:<a href=\"https://doi.org/10.1038/nature11187\">10.1038/nature11187</a>.","ista":"Waitukaitis SR, Jaeger H. 2012. Impact-activated solidification of dense suspensions via dynamic jamming fronts. Nature. 487(7406), 205–209."},"day":"12","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","oa_version":"None","acknowledgement":"This work was supported by NSF through its MRSEC programme (DMR-0820054) and by the US Army Research Office through grant number W911NF-12-1-0182. S.R.W. acknowledges support from a Millikan fellowship.","date_updated":"2021-01-12T06:48:30Z","publication_status":"published","month":"07","type":"journal_article","publist_id":"7941","abstract":[{"lang":"eng","text":"Although liquids typically flow around intruding objects, a counterintuitive phenomenon occurs in dense suspensions of micrometre-sized particles: they become liquid-like when perturbed lightly, but harden when driven strongly. Rheological experiments have investigated how such thickening arises under shear, and linked it to hydrodynamic interactions or granular dilation. However, neither of these mechanisms alone can explain the ability of suspensions to generate very large, positive normal stresses under impact. To illustrate the phenomenon, such stresses can be large enough to allow a person to run across a suspension without sinking, and far exceed the upper limit observed under shear or extension. Here we show that these stresses originate from an impact-generated solidification front that transforms an initially compressible particle matrix into a rapidly growing jammed region, ultimately leading to extraordinary amounts of momentum absorption. Using high-speed videography, embedded force sensing and X-ray imaging, we capture the detailed dynamics of this process as it decelerates a metal rod hitting a suspension of cornflour (cornstarch) in water. We develop a model for the dynamic solidification and its effect on the surrounding suspension that reproduces the observed behaviour quantitatively. Our findings suggest that prior interpretations of the impact resistance as dominated by shear thickening need to be revisited."}],"doi":"10.1038/nature11187","issue":"7406","_id":"113","status":"public"},{"publisher":"Universidad de La Habana","page":"1E31 - 1E33","intvolume":"        29","language":[{"iso":"eng"}],"status":"public","abstract":[{"text":"We report on an investigation of the solidification of a cornstarch and water suspension during normal impact on its surface. We find that a finite time after impact, the suspension displays characteristics reminiscent of a solid, including localized stress transmission, the development of a yield stress, and some elastic energy storage. The time dependence of these characteristics depends on the thickness of the cornstarch layer, showing that the solidification is a dynamic process driven by the impacting object. These findings confirm previous speculations that rapidly applied normal stress transforms the normally fluid-like suspension into a temporarily jammed solid and draw a clear distinction between the effects of normal stress and shear stress in dense suspensions.","lang":"eng"}],"publist_id":"7940","license":"https://creativecommons.org/licenses/by-nc/4.0/","issue":"1E","month":"08","extern":"1","day":"14","publication_status":"published","acknowledgement":"This work was supported by the NSF through its MRSEC program (DMR-0820054). S. R. W. acknowledges support from a Millikan fellowship.","tmp":{"image":"/images/cc_by_nc.png","short":"CC BY-NC (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)"},"quality_controlled":"1","date_published":"2012-08-14T00:00:00Z","title":"Solidification of a cornstarch and water suspension","date_created":"2018-12-11T11:44:42Z","ddc":["530"],"volume":29,"publication":"Revista Cubana de Fisica","year":"2012","_id":"114","file_date_updated":"2019-05-16T11:08:52Z","type":"journal_article","author":[{"orcid":"0000-0002-2299-3176","id":"3A1FFC16-F248-11E8-B48F-1D18A9856A87","full_name":"Waitukaitis, Scott R","first_name":"Scott R","last_name":"Waitukaitis"},{"full_name":"Jaeger, Heinrich","first_name":"Heinrich","last_name":"Jaeger"}],"oa":1,"has_accepted_license":"1","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","citation":{"apa":"Waitukaitis, S. R., &#38; Jaeger, H. (2012). Solidification of a cornstarch and water suspension. <i>Revista Cubana de Fisica</i>. Universidad de La Habana.","mla":"Waitukaitis, Scott R., and Heinrich Jaeger. “Solidification of a Cornstarch and Water Suspension.” <i>Revista Cubana de Fisica</i>, vol. 29, no. 1E, Universidad de La Habana, 2012, p. 1E31-1E33.","ista":"Waitukaitis SR, Jaeger H. 2012. Solidification of a cornstarch and water suspension. Revista Cubana de Fisica. 29(1E), 1E31-1E33.","ieee":"S. R. Waitukaitis and H. Jaeger, “Solidification of a cornstarch and water suspension,” <i>Revista Cubana de Fisica</i>, vol. 29, no. 1E. Universidad de La Habana, p. 1E31-1E33, 2012.","chicago":"Waitukaitis, Scott R, and Heinrich Jaeger. “Solidification of a Cornstarch and Water Suspension.” <i>Revista Cubana de Fisica</i>. Universidad de La Habana, 2012.","ama":"Waitukaitis SR, Jaeger H. Solidification of a cornstarch and water suspension. <i>Revista Cubana de Fisica</i>. 2012;29(1E):1E31-1E33.","short":"S.R. Waitukaitis, H. Jaeger, Revista Cubana de Fisica 29 (2012) 1E31-1E33."},"file":[{"relation":"main_file","creator":"kschuh","file_name":"2012_RCF_Waitukaitis.pdf","file_size":589776,"content_type":"application/pdf","date_updated":"2019-05-16T11:08:52Z","access_level":"open_access","success":1,"date_created":"2019-05-16T11:08:52Z","file_id":"6461"}],"oa_version":"Published Version","date_updated":"2021-01-12T06:48:34Z"},{"date_published":"2012-10-29T00:00:00Z","title":"Maximizing revenue from strategic recommendations under decaying trust","quality_controlled":"1","conference":{"start_date":"2012-10-29","location":"Maui, HI, United States","end_date":"2012-11-02","name":"CIKM: Conference on Information and Knowledge Management"},"publisher":"Association for Computing Machinery","year":"2012","publication":"Proceedings of the 21st ACM international conference on Information and knowledge management","article_processing_charge":"No","language":[{"iso":"eng"}],"date_created":"2022-07-27T06:47:53Z","page":"2268-2286","doi":"10.1145/2396761.2398621","abstract":[{"text":"Suppose your sole interest in recommending a product to me is to maximize the amount paid to you by the seller for a sequence of recommendations. How should you recommend optimally if I become more inclined to ignore you with each irrelevant recommendation you make? Finding an answer to this question is a key challenge in all forms of marketing that rely on and explore social ties; ranging from personal recommendations to viral marketing.\r\n\r\nWe prove that even if the recommendee regains her initial trust on each successful recommendation, the expected revenue the recommender can make over an infinite period due to payments by the seller is bounded. This can only be overcome when the recommendee also incrementally regains trust during periods without any recommendation. Here, we see a connection to \"banner blindness,\" suggesting that showing fewer ads can lead to a higher long-term revenue.","lang":"eng"}],"scopus_import":"1","status":"public","_id":"11656","publication_identifier":{"isbn":["9781450311564"]},"oa_version":"None","publication_status":"published","date_updated":"2023-02-09T09:19:49Z","citation":{"ista":"Dütting P, Henzinger MH, Weber I. 2012. Maximizing revenue from strategic recommendations under decaying trust. Proceedings of the 21st ACM international conference on Information and knowledge management. CIKM: Conference on Information and Knowledge Management, 2268–2286.","mla":"Dütting, Paul, et al. “Maximizing Revenue from Strategic Recommendations under Decaying Trust.” <i>Proceedings of the 21st ACM International Conference on Information and Knowledge Management</i>, Association for Computing Machinery, 2012, pp. 2268–86, doi:<a href=\"https://doi.org/10.1145/2396761.2398621\">10.1145/2396761.2398621</a>.","apa":"Dütting, P., Henzinger, M. H., &#38; Weber, I. (2012). Maximizing revenue from strategic recommendations under decaying trust. In <i>Proceedings of the 21st ACM international conference on Information and knowledge management</i> (pp. 2268–2286). Maui, HI, United States: Association for Computing Machinery. <a href=\"https://doi.org/10.1145/2396761.2398621\">https://doi.org/10.1145/2396761.2398621</a>","ieee":"P. Dütting, M. H. Henzinger, and I. Weber, “Maximizing revenue from strategic recommendations under decaying trust,” in <i>Proceedings of the 21st ACM international conference on Information and knowledge management</i>, Maui, HI, United States, 2012, pp. 2268–2286.","ama":"Dütting P, Henzinger MH, Weber I. Maximizing revenue from strategic recommendations under decaying trust. In: <i>Proceedings of the 21st ACM International Conference on Information and Knowledge Management</i>. Association for Computing Machinery; 2012:2268-2286. doi:<a href=\"https://doi.org/10.1145/2396761.2398621\">10.1145/2396761.2398621</a>","short":"P. Dütting, M.H. Henzinger, I. Weber, in:, Proceedings of the 21st ACM International Conference on Information and Knowledge Management, Association for Computing Machinery, 2012, pp. 2268–2286.","chicago":"Dütting, Paul, Monika H Henzinger, and Ingmar Weber. “Maximizing Revenue from Strategic Recommendations under Decaying Trust.” In <i>Proceedings of the 21st ACM International Conference on Information and Knowledge Management</i>, 2268–86. Association for Computing Machinery, 2012. <a href=\"https://doi.org/10.1145/2396761.2398621\">https://doi.org/10.1145/2396761.2398621</a>."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","day":"29","author":[{"full_name":"Dütting, Paul","first_name":"Paul","last_name":"Dütting"},{"orcid":"0000-0002-5008-6530","full_name":"Henzinger, Monika H","first_name":"Monika H","id":"540c9bbd-f2de-11ec-812d-d04a5be85630","last_name":"Henzinger"},{"last_name":"Weber","first_name":"Ingmar","full_name":"Weber, Ingmar"}],"extern":"1","type":"conference","month":"10"},{"date_published":"2012-08-01T00:00:00Z","title":"Thermoelectric properties of Ho-doped Bi0.88Sb0.12","quality_controlled":"1","date_created":"2022-08-08T08:28:20Z","year":"2012","volume":47,"article_processing_charge":"No","publication":"Journal of Materials Science","_id":"11751","external_id":{"arxiv":["1201.6304"]},"scopus_import":"1","type":"journal_article","oa_version":"Preprint","date_updated":"2022-08-11T09:34:39Z","author":[{"last_name":"Lukas","full_name":"Lukas, K. C.","first_name":"K. C."},{"last_name":"Joshi","first_name":"G.","full_name":"Joshi, G."},{"first_name":"Kimberly A","id":"13C26AC0-EB69-11E9-87C6-5F3BE6697425","full_name":"Modic, Kimberly A","orcid":"0000-0001-9760-3147","last_name":"Modic"},{"last_name":"Ren","first_name":"Z. F.","full_name":"Ren, Z. F."},{"last_name":"Opeil","full_name":"Opeil, C. P.","first_name":"C. P."}],"citation":{"mla":"Lukas, K. C., et al. “Thermoelectric Properties of Ho-Doped Bi0.88Sb0.12.” <i>Journal of Materials Science</i>, vol. 47, no. 15, Springer Nature, 2012, pp. 5729–34, doi:<a href=\"https://doi.org/10.1007/s10853-012-6463-6\">10.1007/s10853-012-6463-6</a>.","apa":"Lukas, K. C., Joshi, G., Modic, K. A., Ren, Z. F., &#38; Opeil, C. P. (2012). Thermoelectric properties of Ho-doped Bi0.88Sb0.12. <i>Journal of Materials Science</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s10853-012-6463-6\">https://doi.org/10.1007/s10853-012-6463-6</a>","ista":"Lukas KC, Joshi G, Modic KA, Ren ZF, Opeil CP. 2012. Thermoelectric properties of Ho-doped Bi0.88Sb0.12. Journal of Materials Science. 47(15), 5729–5734.","ieee":"K. C. Lukas, G. Joshi, K. A. Modic, Z. F. Ren, and C. P. Opeil, “Thermoelectric properties of Ho-doped Bi0.88Sb0.12,” <i>Journal of Materials Science</i>, vol. 47, no. 15. Springer Nature, pp. 5729–5734, 2012.","chicago":"Lukas, K. C., G. Joshi, Kimberly A Modic, Z. F. Ren, and C. P. Opeil. “Thermoelectric Properties of Ho-Doped Bi0.88Sb0.12.” <i>Journal of Materials Science</i>. Springer Nature, 2012. <a href=\"https://doi.org/10.1007/s10853-012-6463-6\">https://doi.org/10.1007/s10853-012-6463-6</a>.","short":"K.C. Lukas, G. Joshi, K.A. Modic, Z.F. Ren, C.P. Opeil, Journal of Materials Science 47 (2012) 5729–5734.","ama":"Lukas KC, Joshi G, Modic KA, Ren ZF, Opeil CP. Thermoelectric properties of Ho-doped Bi0.88Sb0.12. <i>Journal of Materials Science</i>. 2012;47(15):5729-5734. doi:<a href=\"https://doi.org/10.1007/s10853-012-6463-6\">10.1007/s10853-012-6463-6</a>"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"Springer Nature","intvolume":"        47","page":"5729-5734","article_type":"original","language":[{"iso":"eng"}],"arxiv":1,"status":"public","publication_identifier":{"eissn":["1573-4803"],"issn":["0022-2461"]},"issue":"15","doi":"10.1007/s10853-012-6463-6","abstract":[{"lang":"eng","text":"The Seebeck coefficients, electrical resistivities, total thermal conductivities, and magnetization are reported for temperatures between 5 and 350 K for n-type Bi0.88Sb0.12 nano-composite alloys made by Ho-doping at the 0, 1, and 3 % atomic levels. The alloys were prepared using a dc hot-pressing method, and are shown to be single phase for both Ho contents with grain sizes on the average of 900 nm. We find the parent compound has a maximum of ZT = 0.28 at 231 K, while doping 1 % Ho increases the maximum ZT to 0.31 at 221 K and the 3 % doped sample suppresses the maximum ZT = 0.24 at a temperature of 260 K."}],"month":"08","publication_status":"published","extern":"1","day":"01"},{"arxiv":1,"language":[{"iso":"eng"}],"page":"44–57","intvolume":"      7695","publisher":"Springer Nature","extern":"1","day":"01","publication_status":"published","related_material":{"record":[{"relation":"later_version","id":"11794","status":"public"}]},"month":"12","alternative_title":["LNCS"],"doi":"10.1007/978-3-642-35311-6_4","abstract":[{"text":"We study individual rational, Pareto optimal, and incentive compatible mechanisms for auctions with heterogeneous items and budget limits. For multi-dimensional valuations we show that there can be no deterministic mechanism with these properties for divisible items. We use this to show that there can also be no randomized mechanism that achieves this for either divisible or indivisible items. For single-dimensional valuations we show that there can be no deterministic mechanism with these properties for indivisible items, but that there is a randomized mechanism that achieves this for either divisible or indivisible items. The impossibility results hold for public budgets, while the mechanism allows private budgets, which is in both cases the harder variant to show. While all positive results are polynomial-time algorithms, all negative results hold independent of complexity considerations.","lang":"eng"}],"publication_identifier":{"isbn":["9783642353109"],"issn":["1611-3349"]},"status":"public","article_processing_charge":"No","volume":7695,"publication":"8th International Workshop on Internet and Network Economics","year":"2012","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1209.6448"}],"date_created":"2022-08-11T11:32:25Z","quality_controlled":"1","date_published":"2012-12-01T00:00:00Z","title":"Auctions with heterogeneous items and budget limits","conference":{"end_date":"2012-12-14","start_date":"2012-12-11","location":"Liverpool, United Kingdom","name":"WINE: International Conference on Web and Internet Economics"},"author":[{"full_name":"Dütting, Paul","first_name":"Paul","last_name":"Dütting"},{"last_name":"Henzinger","orcid":"0000-0002-5008-6530","full_name":"Henzinger, Monika H","id":"540c9bbd-f2de-11ec-812d-d04a5be85630","first_name":"Monika H"},{"first_name":"Martin","full_name":"Starnberger, Martin","last_name":"Starnberger"}],"oa":1,"citation":{"ista":"Dütting P, Henzinger MH, Starnberger M. 2012. Auctions with heterogeneous items and budget limits. 8th International Workshop on Internet and Network Economics. WINE: International Conference on Web and Internet Economics, LNCS, vol. 7695, 44–57.","apa":"Dütting, P., Henzinger, M. H., &#38; Starnberger, M. (2012). Auctions with heterogeneous items and budget limits. In <i>8th International Workshop on Internet and Network Economics</i> (Vol. 7695, pp. 44–57). Liverpool, United Kingdom: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-642-35311-6_4\">https://doi.org/10.1007/978-3-642-35311-6_4</a>","mla":"Dütting, Paul, et al. “Auctions with Heterogeneous Items and Budget Limits.” <i>8th International Workshop on Internet and Network Economics</i>, vol. 7695, Springer Nature, 2012, pp. 44–57, doi:<a href=\"https://doi.org/10.1007/978-3-642-35311-6_4\">10.1007/978-3-642-35311-6_4</a>.","short":"P. Dütting, M.H. Henzinger, M. Starnberger, in:, 8th International Workshop on Internet and Network Economics, Springer Nature, 2012, pp. 44–57.","ama":"Dütting P, Henzinger MH, Starnberger M. Auctions with heterogeneous items and budget limits. In: <i>8th International Workshop on Internet and Network Economics</i>. Vol 7695. Springer Nature; 2012:44–57. doi:<a href=\"https://doi.org/10.1007/978-3-642-35311-6_4\">10.1007/978-3-642-35311-6_4</a>","chicago":"Dütting, Paul, Monika H Henzinger, and Martin Starnberger. “Auctions with Heterogeneous Items and Budget Limits.” In <i>8th International Workshop on Internet and Network Economics</i>, 7695:44–57. Springer Nature, 2012. <a href=\"https://doi.org/10.1007/978-3-642-35311-6_4\">https://doi.org/10.1007/978-3-642-35311-6_4</a>.","ieee":"P. Dütting, M. H. Henzinger, and M. Starnberger, “Auctions with heterogeneous items and budget limits,” in <i>8th International Workshop on Internet and Network Economics</i>, Liverpool, United Kingdom, 2012, vol. 7695, pp. 44–57."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa_version":"Preprint","date_updated":"2023-02-21T16:28:29Z","type":"conference","scopus_import":"1","external_id":{"arxiv":["1209.6448"]},"_id":"11794"},{"publication":"39th International Colloquium on Automata, Languages, and Programming","volume":7392,"article_processing_charge":"No","year":"2012","date_created":"2022-08-11T11:46:51Z","quality_controlled":"1","title":"On multiple keyword sponsored search auctions with budgets","date_published":"2012-07-01T00:00:00Z","conference":{"end_date":"2012-07-13","location":"Warwick, United Kingdom","start_date":"2012-07-09","name":"ICALP: International Colloquium on Automata, Languages, and Programming"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"ama":"Colini-Baldeschi R, Henzinger MH, Leonardi S, Starnberger M. On multiple keyword sponsored search auctions with budgets. In: <i>39th International Colloquium on Automata, Languages, and Programming</i>. Vol 7392. Springer Nature; 2012:1–12. doi:<a href=\"https://doi.org/10.1007/978-3-642-31585-5_1\">10.1007/978-3-642-31585-5_1</a>","short":"R. Colini-Baldeschi, M.H. Henzinger, S. Leonardi, M. Starnberger, in:, 39th International Colloquium on Automata, Languages, and Programming, Springer Nature, 2012, pp. 1–12.","chicago":"Colini-Baldeschi, Riccardo, Monika H Henzinger, Stefano Leonardi, and Martin Starnberger. “On Multiple Keyword Sponsored Search Auctions with Budgets.” In <i>39th International Colloquium on Automata, Languages, and Programming</i>, 7392:1–12. Springer Nature, 2012. <a href=\"https://doi.org/10.1007/978-3-642-31585-5_1\">https://doi.org/10.1007/978-3-642-31585-5_1</a>.","ieee":"R. Colini-Baldeschi, M. H. Henzinger, S. Leonardi, and M. Starnberger, “On multiple keyword sponsored search auctions with budgets,” in <i>39th International Colloquium on Automata, Languages, and Programming</i>, Warwick, United Kingdom, 2012, vol. 7392, pp. 1–12.","ista":"Colini-Baldeschi R, Henzinger MH, Leonardi S, Starnberger M. 2012. On multiple keyword sponsored search auctions with budgets. 39th International Colloquium on Automata, Languages, and Programming. ICALP: International Colloquium on Automata, Languages, and Programming, LNCS, vol. 7392, 1–12.","mla":"Colini-Baldeschi, Riccardo, et al. “On Multiple Keyword Sponsored Search Auctions with Budgets.” <i>39th International Colloquium on Automata, Languages, and Programming</i>, vol. 7392, Springer Nature, 2012, pp. 1–12, doi:<a href=\"https://doi.org/10.1007/978-3-642-31585-5_1\">10.1007/978-3-642-31585-5_1</a>.","apa":"Colini-Baldeschi, R., Henzinger, M. H., Leonardi, S., &#38; Starnberger, M. (2012). On multiple keyword sponsored search auctions with budgets. In <i>39th International Colloquium on Automata, Languages, and Programming</i> (Vol. 7392, pp. 1–12). Warwick, United Kingdom: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-642-31585-5_1\">https://doi.org/10.1007/978-3-642-31585-5_1</a>"},"author":[{"first_name":"Riccardo","full_name":"Colini-Baldeschi, Riccardo","last_name":"Colini-Baldeschi"},{"orcid":"0000-0002-5008-6530","full_name":"Henzinger, Monika H","id":"540c9bbd-f2de-11ec-812d-d04a5be85630","first_name":"Monika H","last_name":"Henzinger"},{"first_name":"Stefano","full_name":"Leonardi, Stefano","last_name":"Leonardi"},{"first_name":"Martin","full_name":"Starnberger, Martin","last_name":"Starnberger"}],"oa_version":"None","date_updated":"2023-02-21T16:28:31Z","type":"conference","scopus_import":"1","_id":"11795","language":[{"iso":"eng"}],"page":"1–12","intvolume":"      7392","publisher":"Springer Nature","day":"01","extern":"1","publication_status":"published","month":"07","related_material":{"record":[{"status":"public","id":"11795","relation":"later_version"}]},"alternative_title":["LNCS"],"abstract":[{"text":"We study multiple keyword sponsored search auctions with budgets. Each keyword has multiple ad slots with a click-through rate. The bidders have additive valuations, which are linear in the click-through rates, and budgets, which are restricting their overall payments. Additionally, the number of slots per keyword assigned to a bidder is bounded.\r\n\r\nWe show the following results: (1) We give the first mechanism for multiple keywords, where click-through rates differ among slots. Our mechanism is incentive compatible in expectation, individually rational in expectation, and Pareto optimal. (2) We study the combinatorial setting, where each bidder is only interested in a subset of the keywords. We give an incentive compatible, individually rational, Pareto optimal, and deterministic mechanism for identical click-through rates. (3) We give an impossibility result for incentive compatible, individually rational, Pareto optimal, and deterministic mechanisms for bidders with diminishing marginal valuations.","lang":"eng"}],"doi":"10.1007/978-3-642-31585-5_1","publication_identifier":{"isbn":["9783642315848"],"issn":["0302-9743"]},"status":"public"},{"quality_controlled":"1","title":"Finite-size scaling at the jamming transition","date_published":"2012-08-27T00:00:00Z","publisher":"American Physical Society","publication":"Physical Review Letters","volume":109,"article_processing_charge":"No","language":[{"iso":"eng"}],"year":"2012","article_type":"original","article_number":"095704","date_created":"2020-04-30T11:44:12Z","intvolume":"       109","abstract":[{"lang":"eng","text":"We present an analysis of finite-size effects in jammed packings of N soft, frictionless spheres at zero temperature. There is a 1/N correction to the discrete jump in the contact number at the transition so that jammed packings exist only above isostaticity. As a result, the canonical power-law scalings of the contact number and elastic moduli break down at low pressure. These quantities exhibit scaling collapse with a nontrivial scaling function, demonstrating that the jamming transition can be considered a phase transition. Scaling is achieved as a function of N in both two and three dimensions, indicating an upper critical dimension of 2."}],"doi":"10.1103/physrevlett.109.095704","issue":"9","publication_identifier":{"issn":["0031-9007","1079-7114"]},"status":"public","_id":"7776","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","day":"27","citation":{"ista":"Goodrich CP, Liu AJ, Nagel SR. 2012. Finite-size scaling at the jamming transition. Physical Review Letters. 109(9), 095704.","apa":"Goodrich, C. P., Liu, A. J., &#38; Nagel, S. R. (2012). Finite-size scaling at the jamming transition. <i>Physical Review Letters</i>. American Physical Society. <a href=\"https://doi.org/10.1103/physrevlett.109.095704\">https://doi.org/10.1103/physrevlett.109.095704</a>","mla":"Goodrich, Carl Peter, et al. “Finite-Size Scaling at the Jamming Transition.” <i>Physical Review Letters</i>, vol. 109, no. 9, 095704, American Physical Society, 2012, doi:<a href=\"https://doi.org/10.1103/physrevlett.109.095704\">10.1103/physrevlett.109.095704</a>.","ama":"Goodrich CP, Liu AJ, Nagel SR. Finite-size scaling at the jamming transition. <i>Physical Review Letters</i>. 2012;109(9). doi:<a href=\"https://doi.org/10.1103/physrevlett.109.095704\">10.1103/physrevlett.109.095704</a>","short":"C.P. Goodrich, A.J. Liu, S.R. Nagel, Physical Review Letters 109 (2012).","chicago":"Goodrich, Carl Peter, Andrea J. Liu, and Sidney R. Nagel. “Finite-Size Scaling at the Jamming Transition.” <i>Physical Review Letters</i>. American Physical Society, 2012. <a href=\"https://doi.org/10.1103/physrevlett.109.095704\">https://doi.org/10.1103/physrevlett.109.095704</a>.","ieee":"C. P. Goodrich, A. J. Liu, and S. R. Nagel, “Finite-size scaling at the jamming transition,” <i>Physical Review Letters</i>, vol. 109, no. 9. American Physical Society, 2012."},"extern":"1","author":[{"orcid":"0000-0002-1307-5074","first_name":"Carl Peter","id":"EB352CD2-F68A-11E9-89C5-A432E6697425","full_name":"Goodrich, Carl Peter","last_name":"Goodrich"},{"last_name":"Liu","first_name":"Andrea J.","full_name":"Liu, Andrea J."},{"first_name":"Sidney R.","full_name":"Nagel, Sidney R.","last_name":"Nagel"}],"date_updated":"2021-01-12T08:15:27Z","publication_status":"published","oa_version":"None","type":"journal_article","month":"08"},{"acknowledgement":"This work was supported by the Deutsche Forschungsgemeinschaft.","publication_status":"published","day":"28","extern":"1","month":"12","issue":"53","publist_id":"6852","doi":"10.1074/jbc.M112.398321","abstract":[{"lang":"eng","text":"Fungal cell walls frequently contain a polymer of mannose and galactose called galactomannan. In the pathogenic filamentous fungus Aspergillus fumigatus, this polysaccharide is made of a linear mannan backbone with side chains of galactofuran and is anchored to the plasma membrane via a glycosylphosphatidylinositol or is covalently linked to the cell wall. To date, the biosynthesis and significance of this polysaccharide are unknown. The present data demonstrate that deletion of the Golgi UDP-galactofuranose transporter GlfB or the GDP-mannose transporter GmtA leads to the absence of galactofuran or galactomannan, respectively. This indicates that the biosynthesis of galactomannan probably occurs in the lumen of the Golgi apparatus and thus contrasts with the biosynthesis of other fungal cell wall polysaccharides studied to date that takes place at the plasma membrane. Transglycosylation of galactomannan from the membrane to the cell wall is hypothesized because both the cell wall-bound and membrane-bound polysaccharide forms are affected in the generated mutants. Considering the severe growth defect of the A. fumigatus GmtA-deficient mutant, proving this paradigm might provide new targets for antifungal therapy."}],"pmid":1,"status":"public","language":[{"iso":"eng"}],"intvolume":"       287","page":"44418 - 44424","article_type":"original","publisher":"American Society for Biochemistry and Molecular Biology","oa_version":"None","date_updated":"2022-03-21T07:57:14Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"short":"J. Engel, P.S. Schmalhorst, F. Routier, Journal of Biological Chemistry 287 (2012) 44418–44424.","ama":"Engel J, Schmalhorst PS, Routier F. Biosynthesis of the fungal cell wall polysaccharide galactomannan requires intraluminal GDP-mannose. <i>Journal of Biological Chemistry</i>. 2012;287(53):44418-44424. doi:<a href=\"https://doi.org/10.1074/jbc.M112.398321\">10.1074/jbc.M112.398321</a>","chicago":"Engel, Jakob, Philipp S Schmalhorst, and Françoise Routier. “Biosynthesis of the Fungal Cell Wall Polysaccharide Galactomannan Requires Intraluminal GDP-Mannose.” <i>Journal of Biological Chemistry</i>. American Society for Biochemistry and Molecular Biology, 2012. <a href=\"https://doi.org/10.1074/jbc.M112.398321\">https://doi.org/10.1074/jbc.M112.398321</a>.","ieee":"J. Engel, P. S. Schmalhorst, and F. Routier, “Biosynthesis of the fungal cell wall polysaccharide galactomannan requires intraluminal GDP-mannose,” <i>Journal of Biological Chemistry</i>, vol. 287, no. 53. American Society for Biochemistry and Molecular Biology, pp. 44418–44424, 2012.","ista":"Engel J, Schmalhorst PS, Routier F. 2012. Biosynthesis of the fungal cell wall polysaccharide galactomannan requires intraluminal GDP-mannose. Journal of Biological Chemistry. 287(53), 44418–44424.","apa":"Engel, J., Schmalhorst, P. S., &#38; Routier, F. (2012). Biosynthesis of the fungal cell wall polysaccharide galactomannan requires intraluminal GDP-mannose. <i>Journal of Biological Chemistry</i>. American Society for Biochemistry and Molecular Biology. <a href=\"https://doi.org/10.1074/jbc.M112.398321\">https://doi.org/10.1074/jbc.M112.398321</a>","mla":"Engel, Jakob, et al. “Biosynthesis of the Fungal Cell Wall Polysaccharide Galactomannan Requires Intraluminal GDP-Mannose.” <i>Journal of Biological Chemistry</i>, vol. 287, no. 53, American Society for Biochemistry and Molecular Biology, 2012, pp. 44418–24, doi:<a href=\"https://doi.org/10.1074/jbc.M112.398321\">10.1074/jbc.M112.398321</a>."},"author":[{"first_name":"Jakob","full_name":"Engel, Jakob","last_name":"Engel"},{"last_name":"Schmalhorst","id":"309D50DA-F248-11E8-B48F-1D18A9856A87","first_name":"Philipp S","full_name":"Schmalhorst, Philipp S","orcid":"0000-0002-5795-0133"},{"last_name":"Routier","full_name":"Routier, Françoise","first_name":"Françoise"}],"type":"journal_article","external_id":{"pmid":["23139423"]},"scopus_import":"1","_id":"801","year":"2012","publication":"Journal of Biological Chemistry","article_processing_charge":"No","volume":287,"date_created":"2018-12-11T11:48:34Z","date_published":"2012-12-28T00:00:00Z","title":"Biosynthesis of the fungal cell wall polysaccharide galactomannan requires intraluminal GDP-mannose","quality_controlled":"1"},{"date_created":"2020-06-25T13:09:06Z","year":"2012","volume":86,"article_processing_charge":"No","publication":"Physical Review E","date_published":"2012-06-11T00:00:00Z","title":"Non-normal amplification in random balanced neuronal networks","quality_controlled":"1","type":"journal_article","oa_version":"None","date_updated":"2021-01-12T08:16:35Z","author":[{"full_name":"Hennequin, Guillaume","first_name":"Guillaume","last_name":"Hennequin"},{"orcid":"0000-0003-3295-6181","full_name":"Vogels, Tim P","first_name":"Tim P","id":"CB6FF8D2-008F-11EA-8E08-2637E6697425","last_name":"Vogels"},{"last_name":"Gerstner","first_name":"Wulfram","full_name":"Gerstner, Wulfram"}],"user_id":"D865714E-FA4E-11E9-B85B-F5C5E5697425","citation":{"ista":"Hennequin G, Vogels TP, Gerstner W. 2012. Non-normal amplification in random balanced neuronal networks. Physical Review E. 86(1), 011909.","apa":"Hennequin, G., Vogels, T. P., &#38; Gerstner, W. (2012). Non-normal amplification in random balanced neuronal networks. <i>Physical Review E</i>. American Physical Society. <a href=\"https://doi.org/10.1103/physreve.86.011909\">https://doi.org/10.1103/physreve.86.011909</a>","mla":"Hennequin, Guillaume, et al. “Non-Normal Amplification in Random Balanced Neuronal Networks.” <i>Physical Review E</i>, vol. 86, no. 1, 011909, American Physical Society, 2012, doi:<a href=\"https://doi.org/10.1103/physreve.86.011909\">10.1103/physreve.86.011909</a>.","ieee":"G. Hennequin, T. P. Vogels, and W. Gerstner, “Non-normal amplification in random balanced neuronal networks,” <i>Physical Review E</i>, vol. 86, no. 1. American Physical Society, 2012.","ama":"Hennequin G, Vogels TP, Gerstner W. Non-normal amplification in random balanced neuronal networks. <i>Physical Review E</i>. 2012;86(1). doi:<a href=\"https://doi.org/10.1103/physreve.86.011909\">10.1103/physreve.86.011909</a>","short":"G. Hennequin, T.P. Vogels, W. Gerstner, Physical Review E 86 (2012).","chicago":"Hennequin, Guillaume, Tim P Vogels, and Wulfram Gerstner. “Non-Normal Amplification in Random Balanced Neuronal Networks.” <i>Physical Review E</i>. American Physical Society, 2012. <a href=\"https://doi.org/10.1103/physreve.86.011909\">https://doi.org/10.1103/physreve.86.011909</a>."},"_id":"8024","external_id":{"pmid":["23005454"]},"intvolume":"        86","article_number":"011909","article_type":"original","language":[{"iso":"eng"}],"publisher":"American Physical Society","month":"06","publication_status":"published","extern":"1","day":"11","pmid":1,"status":"public","publication_identifier":{"issn":["1539-3755"],"eisbn":["1550-2376"]},"issue":"1","abstract":[{"text":"In dynamical models of cortical networks, the recurrent connectivity can amplify the input given to the network in two distinct ways. One is induced by the presence of near-critical eigenvalues in the connectivity matrix W, producing large but slow activity fluctuations along the corresponding eigenvectors (dynamical slowing). The other relies on W not being normal, which allows the network activity to make large but fast excursions along specific directions. Here we investigate the trade-off between non-normal amplification and dynamical slowing in the spontaneous activity of large random neuronal networks composed of excitatory and inhibitory neurons. We use a Schur decomposition of W to separate the two amplification mechanisms. Assuming linear stochastic dynamics, we derive an exact expression for the expected amount of purely non-normal amplification. We find that amplification is very limited if dynamical slowing must be kept weak. We conclude that, to achieve strong transient amplification with little slowing, the connectivity must be structured. We show that unidirectional connections between neurons of the same type together with reciprocal connections between neurons of different types, allow for amplification already in the fast dynamical regime. Finally, our results also shed light on the differences between balanced networks in which inhibition exactly cancels excitation and those where inhibition dominates.","lang":"eng"}],"doi":"10.1103/physreve.86.011909"},{"status":"public","issue":"11","license":"https://creativecommons.org/licenses/by-nc-sa/4.0/","publist_id":"6842","abstract":[{"lang":"eng","text":"Using correlated live-cell imaging and electron tomography we found that actin branch junctions in protruding and treadmilling lamellipodia are not concentrated at the front as previously supposed, but link actin filament subsets in which there is a continuum of distances from a junction to the filament plus ends, for up to at least 1 mm. When branch sites were observed closely spaced on the same filament their separation was commonly a multiple of the actin helical repeat of 36 nm. Image averaging of branch junctions in the tomograms yielded a model for the in vivo branch at 2.9 nm resolution, which was comparable with that derived for the in vitro actin- Arp2/3 complex. Lamellipodium initiation was monitored in an intracellular wound-healing model and was found to involve branching from the sides of actin filaments oriented parallel to the plasmalemma. Many filament plus ends, presumably capped, terminated behind the lamellipodium tip and localized on the dorsal and ventral surfaces of the actin network. These findings reveal how branching events initiate and maintain a network of actin filaments of variable length, and provide the first structural model of the branch junction in vivo. A possible role of filament capping in generating the lamellipodium leaflet is discussed and a mathematical model of protrusion is also presented."}],"doi":"10.1242/jcs.107623","month":"06","acknowledgement":"This work was supported by the Austrian Science Fund [projects FWF I516-B09 and FWF P21292-B09 to J.V.S.]; the Vienna Science and Technology Fund [WWTF-grant numbers MA 09-004 to J.V.S. and C.S], ZIT - The Technology Agency of the City of Vienna [VSOE, CMCN to J.V.S. and G.P.R.]; the Deutsche Forschungsgemeinschaft [grant number RO 2414/1-2 to K.R.]; the Daiko research foundation [grant number 9134 to A.N.]; and a Grant-in-Aid for Scientific Research [S, grant number 20227008 to Y.M.] and a Grant-in-Aid for Young Scientists [B, grant number 22770145 to A.N.] (B) from The Ministry of Education, Culture, Sports, Science and Technology of the Japanese Government. Deposited in PMC for immediate release. We thank Tibor Kulcsar for assistance with graphics.","publication_status":"published","day":"01","extern":"1","publisher":"Company of Biologists","intvolume":"       125","page":"2775 - 2785","language":[{"iso":"eng"}],"_id":"808","file_date_updated":"2020-07-14T12:48:09Z","type":"journal_article","oa_version":"None","date_updated":"2021-01-12T08:16:47Z","file":[{"date_created":"2019-02-12T08:54:51Z","file_id":"5956","access_level":"open_access","file_size":3326073,"date_updated":"2020-07-14T12:48:09Z","content_type":"application/pdf","file_name":"2012_Biologists_Vinzenz.pdf","creator":"kschuh","relation":"main_file","checksum":"2f59e15cc3a85bb500a9887cef2aab67"}],"has_accepted_license":"1","citation":{"ista":"Vinzenz M, Nemethova M, Schur FK, Mueller J, Narita A, Urban E, Winkler C, Schmeiser C, Koestler S, Rottner K, Resch G, Maéda Y, Small J. 2012. Actin branching in the initiation and maintenance of lamellipodia. Journal of Cell Science. 125(11), 2775–2785.","apa":"Vinzenz, M., Nemethova, M., Schur, F. K., Mueller, J., Narita, A., Urban, E., … Small, J. (2012). Actin branching in the initiation and maintenance of lamellipodia. <i>Journal of Cell Science</i>. Company of Biologists. <a href=\"https://doi.org/10.1242/jcs.107623\">https://doi.org/10.1242/jcs.107623</a>","mla":"Vinzenz, Marlene, et al. “Actin Branching in the Initiation and Maintenance of Lamellipodia.” <i>Journal of Cell Science</i>, vol. 125, no. 11, Company of Biologists, 2012, pp. 2775–85, doi:<a href=\"https://doi.org/10.1242/jcs.107623\">10.1242/jcs.107623</a>.","short":"M. Vinzenz, M. Nemethova, F.K. Schur, J. Mueller, A. Narita, E. Urban, C. Winkler, C. Schmeiser, S. Koestler, K. Rottner, G. Resch, Y. Maéda, J. Small, Journal of Cell Science 125 (2012) 2775–2785.","ama":"Vinzenz M, Nemethova M, Schur FK, et al. Actin branching in the initiation and maintenance of lamellipodia. <i>Journal of Cell Science</i>. 2012;125(11):2775-2785. doi:<a href=\"https://doi.org/10.1242/jcs.107623\">10.1242/jcs.107623</a>","chicago":"Vinzenz, Marlene, Maria Nemethova, Florian KM Schur, Jan Mueller, Akihiro Narita, Edit Urban, Christoph Winkler, et al. “Actin Branching in the Initiation and Maintenance of Lamellipodia.” <i>Journal of Cell Science</i>. Company of Biologists, 2012. <a href=\"https://doi.org/10.1242/jcs.107623\">https://doi.org/10.1242/jcs.107623</a>.","ieee":"M. Vinzenz <i>et al.</i>, “Actin branching in the initiation and maintenance of lamellipodia,” <i>Journal of Cell Science</i>, vol. 125, no. 11. Company of Biologists, pp. 2775–2785, 2012."},"user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","author":[{"full_name":"Vinzenz, Marlene","first_name":"Marlene","last_name":"Vinzenz"},{"last_name":"Nemethova","first_name":"Maria","full_name":"Nemethova, Maria","id":"34E27F1C-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Schur","id":"48AD8942-F248-11E8-B48F-1D18A9856A87","first_name":"Florian","full_name":"Schur, Florian","orcid":"0000-0003-4790-8078"},{"last_name":"Mueller","full_name":"Mueller, Jan","first_name":"Jan"},{"full_name":"Narita, Akihiro","first_name":"Akihiro","last_name":"Narita"},{"last_name":"Urban","full_name":"Urban, Edit","first_name":"Edit"},{"full_name":"Winkler, Christoph","first_name":"Christoph","last_name":"Winkler"},{"last_name":"Schmeiser","full_name":"Schmeiser, Christian","first_name":"Christian"},{"first_name":"Stefan","full_name":"Koestler, Stefan","last_name":"Koestler"},{"last_name":"Rottner","full_name":"Rottner, Klemens","first_name":"Klemens"},{"last_name":"Resch","full_name":"Resch, Guenter","first_name":"Guenter"},{"full_name":"Maéda, Yuichiro","first_name":"Yuichiro","last_name":"Maéda"},{"last_name":"Small","full_name":"Small, John","first_name":"John"}],"oa":1,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode","short":"CC BY-NC-SA (4.0)","image":"/images/cc_by_nc_sa.png","name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)"},"date_published":"2012-06-01T00:00:00Z","title":"Actin branching in the initiation and maintenance of lamellipodia","quality_controlled":"1","ddc":["570"],"date_created":"2018-12-11T11:48:37Z","year":"2012","publication":"Journal of Cell Science","volume":125},{"language":[{"iso":"eng"}],"intvolume":"       333","page":"109-120","article_type":"original","publisher":"Oxford University Press","publication_status":"published","extern":"1","day":"01","month":"08","issue":"2","abstract":[{"lang":"eng","text":"The Staphylococcus aureus cell wall stress stimulon (CWSS) is activated by cell envelope-targeting antibiotics or depletion of essential cell wall biosynthesis enzymes. The functionally uncharacterized S. aureus LytR-CpsA-Psr (LCP) proteins, MsrR, SA0908 and SA2103, all belong to the CWSS. Although not essential, deletion of all three LCP proteins severely impairs cell division. We show here that VraSR-dependent CWSS expression was up to 250-fold higher in single, double and triple LCP mutants than in wild type S. aureus in the absence of external stress. The LCP triple mutant was virtually depleted of wall teichoic acids (WTA), which could be restored to different degrees by any of the single LCP proteins. Subinhibitory concentrations of tunicamycin, which inhibits the first WTA synthesis enzyme TarO (TagO), could partially complement the severe growth defect of the LCP triple mutant. Both of the latter findings support a role for S. aureus LCP proteins in late WTA synthesis, as in Bacillus subtilis where LCP proteins were recently proposed to transfer WTA from lipid carriers to the cell wall peptidoglycan. Intrinsic activation of the CWSS upon LCP deletion and the fact that LCP proteins were essential for WTA-loading of the cell wall, highlight their important role(s) in S. aureus cell envelope biogenesis."}],"doi":"10.1111/j.1574-6968.2012.02603.x","pmid":1,"status":"public","publication_identifier":{"issn":["0378-1097"]},"year":"2012","volume":333,"article_processing_charge":"No","publication":"FEMS Microbiology Letters","date_created":"2020-08-10T11:54:47Z","date_published":"2012-08-01T00:00:00Z","title":"Deletion of hypothetical wall teichoic acid ligases in Staphylococcus aureus activates the cell wall stress response","quality_controlled":"1","date_updated":"2021-01-12T08:17:43Z","oa_version":"None","author":[{"full_name":"Dengler, Vanina","first_name":"Vanina","last_name":"Dengler"},{"full_name":"Meier, Patricia Stutzmann","first_name":"Patricia Stutzmann","last_name":"Meier"},{"first_name":"Ronald","full_name":"Heusser, Ronald","last_name":"Heusser"},{"last_name":"Kupferschmied","full_name":"Kupferschmied, Peter","first_name":"Peter"},{"last_name":"Fazekas","id":"36432834-F248-11E8-B48F-1D18A9856A87","full_name":"Fazekas, Judit","first_name":"Judit","orcid":"0000-0002-8777-3502"},{"last_name":"Friebe","first_name":"Sarah","full_name":"Friebe, Sarah"},{"first_name":"Sibylle Burger","full_name":"Staufer, Sibylle Burger","last_name":"Staufer"},{"first_name":"Paul A.","full_name":"Majcherczyk, Paul A.","last_name":"Majcherczyk"},{"last_name":"Moreillon","full_name":"Moreillon, Philippe","first_name":"Philippe"},{"last_name":"Berger-Bächi","first_name":"Brigitte","full_name":"Berger-Bächi, Brigitte"},{"last_name":"McCallum","first_name":"Nadine","full_name":"McCallum, Nadine"}],"citation":{"ista":"Dengler V, Meier PS, Heusser R, Kupferschmied P, Singer J, Friebe S, Staufer SB, Majcherczyk PA, Moreillon P, Berger-Bächi B, McCallum N. 2012. Deletion of hypothetical wall teichoic acid ligases in Staphylococcus aureus activates the cell wall stress response. FEMS Microbiology Letters. 333(2), 109–120.","mla":"Dengler, Vanina, et al. “Deletion of Hypothetical Wall Teichoic Acid Ligases in Staphylococcus Aureus Activates the Cell Wall Stress Response.” <i>FEMS Microbiology Letters</i>, vol. 333, no. 2, Oxford University Press, 2012, pp. 109–20, doi:<a href=\"https://doi.org/10.1111/j.1574-6968.2012.02603.x\">10.1111/j.1574-6968.2012.02603.x</a>.","apa":"Dengler, V., Meier, P. S., Heusser, R., Kupferschmied, P., Singer, J., Friebe, S., … McCallum, N. (2012). Deletion of hypothetical wall teichoic acid ligases in Staphylococcus aureus activates the cell wall stress response. <i>FEMS Microbiology Letters</i>. Oxford University Press. <a href=\"https://doi.org/10.1111/j.1574-6968.2012.02603.x\">https://doi.org/10.1111/j.1574-6968.2012.02603.x</a>","ieee":"V. Dengler <i>et al.</i>, “Deletion of hypothetical wall teichoic acid ligases in Staphylococcus aureus activates the cell wall stress response,” <i>FEMS Microbiology Letters</i>, vol. 333, no. 2. Oxford University Press, pp. 109–120, 2012.","ama":"Dengler V, Meier PS, Heusser R, et al. Deletion of hypothetical wall teichoic acid ligases in Staphylococcus aureus activates the cell wall stress response. <i>FEMS Microbiology Letters</i>. 2012;333(2):109-120. doi:<a href=\"https://doi.org/10.1111/j.1574-6968.2012.02603.x\">10.1111/j.1574-6968.2012.02603.x</a>","short":"V. Dengler, P.S. Meier, R. Heusser, P. Kupferschmied, J. Singer, S. Friebe, S.B. Staufer, P.A. Majcherczyk, P. Moreillon, B. Berger-Bächi, N. McCallum, FEMS Microbiology Letters 333 (2012) 109–120.","chicago":"Dengler, Vanina, Patricia Stutzmann Meier, Ronald Heusser, Peter Kupferschmied, Judit Singer, Sarah Friebe, Sibylle Burger Staufer, et al. “Deletion of Hypothetical Wall Teichoic Acid Ligases in Staphylococcus Aureus Activates the Cell Wall Stress Response.” <i>FEMS Microbiology Letters</i>. Oxford University Press, 2012. <a href=\"https://doi.org/10.1111/j.1574-6968.2012.02603.x\">https://doi.org/10.1111/j.1574-6968.2012.02603.x</a>."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"journal_article","external_id":{"pmid":["22640011"]},"_id":"8246"},{"publisher":"Annual Reviews","quality_controlled":0,"title":"Hormonal interactions in the regulation of plant development","date_published":"2012-11-01T00:00:00Z","page":"463 - 487","intvolume":"        28","date_created":"2018-12-11T11:48:43Z","publication":"Annual Review of Cell and Developmental Biology","volume":28,"year":"2012","status":"public","_id":"826","publist_id":"6822","doi":"10.1146/annurev-cellbio-101011-155741","abstract":[{"lang":"eng","text":"Plants exhibit a unique developmental flexibility to ever-changing environmental conditions. To achieve their profound adaptability, plants are able to maintain permanent stem cell populations and form new organs during the entire plant life cycle. Signaling substances, called plant hormones, such as auxin, cytokinin, abscisic acid, brassinosteroid, ethylene, gibberellin, jasmonic acid, and strigolactone, govern and coordinate these developmental processes. Physiological and genetic studies have dissected the molecular components of signal perception and transduction of the individual hormonal pathways. However, over recent years it has become evident that hormones do not act only in a linear pathway. Hormonal pathways are interconnected by a complex network of interactions and feedback circuits that determines the final outcome of the individual hormone actions. This raises questions about the molecular mechanisms underlying hormonal cross talk and about how these hormonal networks are established, maintained, and modulated throughout plant development."}],"type":"journal_article","month":"11","citation":{"ieee":"M. Vanstraelen and E. Benková, “Hormonal interactions in the regulation of plant development,” <i>Annual Review of Cell and Developmental Biology</i>, vol. 28. Annual Reviews, pp. 463–487, 2012.","ama":"Vanstraelen M, Benková E. Hormonal interactions in the regulation of plant development. <i>Annual Review of Cell and Developmental Biology</i>. 2012;28:463-487. doi:<a href=\"https://doi.org/10.1146/annurev-cellbio-101011-155741\">10.1146/annurev-cellbio-101011-155741</a>","short":"M. Vanstraelen, E. Benková, Annual Review of Cell and Developmental Biology 28 (2012) 463–487.","chicago":"Vanstraelen, Marleen, and Eva Benková. “Hormonal Interactions in the Regulation of Plant Development.” <i>Annual Review of Cell and Developmental Biology</i>. Annual Reviews, 2012. <a href=\"https://doi.org/10.1146/annurev-cellbio-101011-155741\">https://doi.org/10.1146/annurev-cellbio-101011-155741</a>.","ista":"Vanstraelen M, Benková E. 2012. Hormonal interactions in the regulation of plant development. Annual Review of Cell and Developmental Biology. 28, 463–487.","apa":"Vanstraelen, M., &#38; Benková, E. (2012). Hormonal interactions in the regulation of plant development. <i>Annual Review of Cell and Developmental Biology</i>. Annual Reviews. <a href=\"https://doi.org/10.1146/annurev-cellbio-101011-155741\">https://doi.org/10.1146/annurev-cellbio-101011-155741</a>","mla":"Vanstraelen, Marleen, and Eva Benková. “Hormonal Interactions in the Regulation of Plant Development.” <i>Annual Review of Cell and Developmental Biology</i>, vol. 28, Annual Reviews, 2012, pp. 463–87, doi:<a href=\"https://doi.org/10.1146/annurev-cellbio-101011-155741\">10.1146/annurev-cellbio-101011-155741</a>."},"day":"01","author":[{"full_name":"Vanstraelen, Marleen","first_name":"Marleen","last_name":"Vanstraelen"},{"first_name":"Eva","id":"38F4F166-F248-11E8-B48F-1D18A9856A87","full_name":"Eva Benková","orcid":"0000-0002-8510-9739","last_name":"Benková"}],"extern":1,"date_updated":"2021-01-12T08:17:46Z","publication_status":"published","acknowledgement":"We would like to thank Annick Bleys for help in preparing the manuscript. This work was supported by the European Research Council with a Starting Independent Research grant (ERC-2007-Stg-207362-HCPO) and the project CZ.1.07/2.3.00/20.0043 (to the Central European Institute of Technology, CEITEC) to E.B. M.V. is a postdoctoral fellow of the Research Foundation Flanders. We apologize that, because of space restrictions, the scientific contributions of only a limited number of original articles could be cited and discussed."},{"status":"public","_id":"829","publist_id":"6819","doi":"10.1105/tpc.112.103044","abstract":[{"lang":"eng","text":"The architecture of a plant's root system, established postembryonically, results from both coordinated root growth and lateral root branching. The plant hormones auxin and cytokinin are central endogenous signaling molecules that regulate lateral root organogenesis positively and negatively, respectively. Tight control and mutual balance of their antagonistic activities are particularly important during the early phases of lateral root organogenesis to ensure continuous lateral root initiation (LRI) and proper development of lateral root primordia (LRP). Here, we show that the early phases of lateral root organogenesis, including priming and initiation, take place in root zones with a repressed cytokinin response. Accordingly, ectopic overproduction of cytokinin in the root basal meristem most efficiently inhibits LRI. Enhanced cytokinin responses in pericycle cells between existing LRP might restrict LRI near existing LRP and, when compromised, ectopic LRI occurs. Furthermore, our results demonstrate that young LRP are more sensitive to perturbations in the cytokinin activity than are developmentally more advanced primordia. We hypothesize that the effect of cytokinin on the development of primordia possibly depends on the robustness and stability of the auxin gradient."}],"issue":"10","type":"journal_article","month":"10","day":"01","citation":{"apa":"Bielach, A., Podlesakova, K., Marhavý, P., Duclercq, J., Cuesta, C., Muller, B., … Benková, E. (2012). Spatiotemporal regulation of lateral root organogenesis in Arabidopsis by cytokinin. <i>The Plant Cell</i>. American Society of Plant Biologists. <a href=\"https://doi.org/10.1105/tpc.112.103044\">https://doi.org/10.1105/tpc.112.103044</a>","mla":"Bielach, Agnieszka, et al. “Spatiotemporal Regulation of Lateral Root Organogenesis in Arabidopsis by Cytokinin.” <i>The Plant Cell</i>, vol. 24, no. 10, American Society of Plant Biologists, 2012, pp. 3967–81, doi:<a href=\"https://doi.org/10.1105/tpc.112.103044\">10.1105/tpc.112.103044</a>.","ista":"Bielach A, Podlesakova K, Marhavý P, Duclercq J, Cuesta C, Muller B, Grunewald W, Tarkowski P, Benková E. 2012. Spatiotemporal regulation of lateral root organogenesis in Arabidopsis by cytokinin. The Plant Cell. 24(10), 3967–3981.","chicago":"Bielach, Agnieszka, Katerina Podlesakova, Peter Marhavý, Jérôme Duclercq, Candela Cuesta, Bruno Muller, Wim Grunewald, Petr Tarkowski, and Eva Benková. “Spatiotemporal Regulation of Lateral Root Organogenesis in Arabidopsis by Cytokinin.” <i>The Plant Cell</i>. American Society of Plant Biologists, 2012. <a href=\"https://doi.org/10.1105/tpc.112.103044\">https://doi.org/10.1105/tpc.112.103044</a>.","ama":"Bielach A, Podlesakova K, Marhavý P, et al. Spatiotemporal regulation of lateral root organogenesis in Arabidopsis by cytokinin. <i>The Plant Cell</i>. 2012;24(10):3967-3981. doi:<a href=\"https://doi.org/10.1105/tpc.112.103044\">10.1105/tpc.112.103044</a>","short":"A. Bielach, K. Podlesakova, P. Marhavý, J. Duclercq, C. Cuesta, B. Muller, W. Grunewald, P. Tarkowski, E. Benková, The Plant Cell 24 (2012) 3967–3981.","ieee":"A. Bielach <i>et al.</i>, “Spatiotemporal regulation of lateral root organogenesis in Arabidopsis by cytokinin,” <i>The Plant Cell</i>, vol. 24, no. 10. American Society of Plant Biologists, pp. 3967–3981, 2012."},"author":[{"full_name":"Bielach, Agnieszka","first_name":"Agnieszka","last_name":"Bielach"},{"last_name":"Podlesakova","full_name":"Podlesakova, Katerina","first_name":"Katerina"},{"last_name":"Marhavy","orcid":"0000-0001-5227-5741","id":"3F45B078-F248-11E8-B48F-1D18A9856A87","full_name":"Peter Marhavy","first_name":"Peter"},{"last_name":"Duclercq","first_name":"Jérôme","full_name":"Duclercq, Jérôme"},{"id":"33A3C818-F248-11E8-B48F-1D18A9856A87","first_name":"Candela","full_name":"Candela Cuesta","orcid":"0000-0003-1923-2410","last_name":"Cuesta"},{"last_name":"Muller","full_name":"Muller, Bruno","first_name":"Bruno"},{"full_name":"Grunewald, Wim","first_name":"Wim","last_name":"Grunewald"},{"first_name":"Petr","full_name":"Tarkowski, Petr","last_name":"Tarkowski"},{"full_name":"Eva Benková","id":"38F4F166-F248-11E8-B48F-1D18A9856A87","first_name":"Eva","orcid":"0000-0002-8510-9739","last_name":"Benková"}],"extern":1,"publication_status":"published","date_updated":"2021-01-12T08:17:55Z","acknowledgement":"We thank Jen Sheen, Dolf Weijers, Tatsuo Kakimoto, Stephen Depuydt, and Laurent Laplaze for sharing published material, Jiri Friml for discussions, and Martine De Cock and Annick Bleys for help in preparing the manuscript. This work was supported by a Starting Independent Research grant from the European Research Council (ERC-2007-Stg-207362-HCPO) and the project CZ.1.07/2.3.00/20.0043 to the Central European Institute of Technology to E.B. and grants from the Ministry of Education, Youth, and Sports of the Czech Republic (MSM 6198959216) and the Centre of the Region Haná for Biotechnological and Agricultural Research (ED0007/01/01) to P.T.","publisher":"American Society of Plant Biologists","quality_controlled":0,"title":"Spatiotemporal regulation of lateral root organogenesis in Arabidopsis by cytokinin","date_published":"2012-10-01T00:00:00Z","page":"3967 - 3981","intvolume":"        24","date_created":"2018-12-11T11:48:43Z","publication":"The Plant Cell","volume":24,"year":"2012"},{"page":"1213 - 1222","date_created":"2018-12-11T11:48:49Z","intvolume":"         4","publication":"Genome Biology and Evolution","volume":4,"year":"2012","publisher":"Oxford University Press","tmp":{"image":"/images/cc_by_nc.png","short":"CC BY-NC (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)"},"quality_controlled":0,"date_published":"2012-01-01T00:00:00Z","title":"Estimating the rate of irreversibility in protein evolution","type":"journal_article","month":"01","day":"01","citation":{"ieee":"O. Soylemez and F. Kondrashov, “Estimating the rate of irreversibility in protein evolution,” <i>Genome Biology and Evolution</i>, vol. 4, no. 12. Oxford University Press, pp. 1213–1222, 2012.","chicago":"Soylemez, Onuralp, and Fyodor Kondrashov. “Estimating the Rate of Irreversibility in Protein Evolution.” <i>Genome Biology and Evolution</i>. Oxford University Press, 2012. <a href=\"https://doi.org/10.1093/gbe/evs096\">https://doi.org/10.1093/gbe/evs096</a>.","short":"O. Soylemez, F. Kondrashov, Genome Biology and Evolution 4 (2012) 1213–1222.","ama":"Soylemez O, Kondrashov F. Estimating the rate of irreversibility in protein evolution. <i>Genome Biology and Evolution</i>. 2012;4(12):1213-1222. doi:<a href=\"https://doi.org/10.1093/gbe/evs096\">10.1093/gbe/evs096</a>","apa":"Soylemez, O., &#38; Kondrashov, F. (2012). Estimating the rate of irreversibility in protein evolution. <i>Genome Biology and Evolution</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/gbe/evs096\">https://doi.org/10.1093/gbe/evs096</a>","mla":"Soylemez, Onuralp, and Fyodor Kondrashov. “Estimating the Rate of Irreversibility in Protein Evolution.” <i>Genome Biology and Evolution</i>, vol. 4, no. 12, Oxford University Press, 2012, pp. 1213–22, doi:<a href=\"https://doi.org/10.1093/gbe/evs096\">10.1093/gbe/evs096</a>.","ista":"Soylemez O, Kondrashov F. 2012. Estimating the rate of irreversibility in protein evolution. Genome Biology and Evolution. 4(12), 1213–1222."},"author":[{"last_name":"Soylemez","full_name":"Soylemez, Onuralp","first_name":"Onuralp"},{"orcid":"0000-0001-8243-4694","first_name":"Fyodor","full_name":"Fyodor Kondrashov","id":"44FDEF62-F248-11E8-B48F-1D18A9856A87","last_name":"Kondrashov"}],"extern":1,"date_updated":"2021-01-12T08:19:25Z","publication_status":"published","acknowledgement":"This work was supported by Plan Nacional grant BFU2009-09271 from the Spanish Ministry of Science and Innovation and by FPU (Formación del Profesorado Universitario) program grant AP2008-01888 from the Spanish Ministry of Education to O.S. F.A.K. is a European Molecular Biology Organization Young Investigator and Howard Hughes Medical Institute International Early Career Scientist.","status":"public","_id":"846","publist_id":"6802","doi":"10.1093/gbe/evs096","abstract":[{"lang":"eng","text":"Whether or not evolutionary change is inherently irreversible remains a controversial topic. Some examples of evolutionary irreversibility are known; however, this question has not been comprehensively addressed at the molecular level. Here, we use data from 221 human genes with known pathogenic mutations to estimate the rate of irreversibility in protein evolution. For these genes, we reconstruct ancestral amino acid sequences along the mammalian phylogeny and identify ancestral amino acid states that match known pathogenic mutations. Such cases represent inherent evolutionary irreversibility because, at the present moment, reversals to these ancestral amino acid states are impossible for the human lineage. We estimate that approximately 10% of all amino acid substitutions along the mammalian phylogeny are irreversible, such that a return to the ancestral amino acid state would lead to a pathogenic phenotype. For a subset of 51 genes with high rates of irreversibility, as much as 40% of all amino acid evolution was estimated to be irreversible. Because pathogenic phenotypes do not resemble ancestral phenotypes, the molecular nature of the high rate of irreversibility in proteins is best explained by evolution with a high prevalence of compensatory, epistatic interactions between amino acid sites. Under such mode of protein evolution, once an amino acid substitution is fixed, the probability of its reversal declines as the protein sequence accumulates changes that affect the phenotypic manifestation of the ancestral state. The prevalence of epistasis in evolution indicates that the observed high rate of irreversibility in protein evolution is an inherent property of protein structure and function."}],"issue":"12"},{"date_published":"2012-08-23T00:00:00Z","title":"Optimal degree of protonation for 1H detection of aliphatic sites in randomly deuterated proteins as a function of the MAS frequency","quality_controlled":"1","publisher":"Springer Nature","year":"2012","publication":"Journal of Biomolecular NMR","volume":54,"article_processing_charge":"No","language":[{"iso":"eng"}],"intvolume":"        54","date_created":"2020-09-18T10:09:18Z","article_type":"original","page":"155-168","issue":"2","abstract":[{"text":"The 1H dipolar network, which is the major obstacle for applying proton detection in the solid-state, can be reduced by deuteration, employing the RAP (Reduced Adjoining Protonation) labeling scheme, which yields random protonation at non-exchangeable sites. We present here a systematic study on the optimal degree of random sidechain protonation in RAP samples as a function of the MAS (magic angle spinning) frequency. In particular, we compare 1H sensitivity and linewidth of a microcrystalline protein, the SH3 domain of chicken α-spectrin, for samples, prepared with 5–25 % H2O in the E. coli growth medium, in the MAS frequency range of 20–60 kHz. At an external field of 19.96 T (850 MHz), we find that using a proton concentration between 15 and 25 % in the M9 medium yields the best compromise in terms of sensitivity and resolution, with an achievable average 1H linewidth on the order of 40–50 Hz. Comparing sensitivities at a MAS frequency of 60 versus 20 kHz, a gain in sensitivity by a factor of 4–4.5 is observed in INEPT-based 1H detected 1D 1H,13C correlation experiments. In total, we find that spectra recorded with a 1.3 mm rotor at 60 kHz have almost the same sensitivity as spectra recorded with a fully packed 3.2 mm rotor at 20 kHz, even though ~20× less material is employed. The improved sensitivity is attributed to 1H line narrowing due to fast MAS and to the increased efficiency of the 1.3 mm coil.","lang":"eng"}],"doi":"10.1007/s10858-012-9659-9","status":"public","_id":"8463","publication_identifier":{"issn":["0925-2738","1573-5001"]},"date_updated":"2021-01-12T08:19:27Z","publication_status":"published","oa_version":"None","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"ieee":"S. Asami, K. Szekely, P. Schanda, B. H. Meier, and B. Reif, “Optimal degree of protonation for 1H detection of aliphatic sites in randomly deuterated proteins as a function of the MAS frequency,” <i>Journal of Biomolecular NMR</i>, vol. 54, no. 2. Springer Nature, pp. 155–168, 2012.","chicago":"Asami, Sam, Kathrin Szekely, Paul Schanda, Beat H. Meier, and Bernd Reif. “Optimal Degree of Protonation for 1H Detection of Aliphatic Sites in Randomly Deuterated Proteins as a Function of the MAS Frequency.” <i>Journal of Biomolecular NMR</i>. Springer Nature, 2012. <a href=\"https://doi.org/10.1007/s10858-012-9659-9\">https://doi.org/10.1007/s10858-012-9659-9</a>.","ama":"Asami S, Szekely K, Schanda P, Meier BH, Reif B. Optimal degree of protonation for 1H detection of aliphatic sites in randomly deuterated proteins as a function of the MAS frequency. <i>Journal of Biomolecular NMR</i>. 2012;54(2):155-168. doi:<a href=\"https://doi.org/10.1007/s10858-012-9659-9\">10.1007/s10858-012-9659-9</a>","short":"S. Asami, K. Szekely, P. Schanda, B.H. Meier, B. Reif, Journal of Biomolecular NMR 54 (2012) 155–168.","apa":"Asami, S., Szekely, K., Schanda, P., Meier, B. H., &#38; Reif, B. (2012). Optimal degree of protonation for 1H detection of aliphatic sites in randomly deuterated proteins as a function of the MAS frequency. <i>Journal of Biomolecular NMR</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s10858-012-9659-9\">https://doi.org/10.1007/s10858-012-9659-9</a>","mla":"Asami, Sam, et al. “Optimal Degree of Protonation for 1H Detection of Aliphatic Sites in Randomly Deuterated Proteins as a Function of the MAS Frequency.” <i>Journal of Biomolecular NMR</i>, vol. 54, no. 2, Springer Nature, 2012, pp. 155–68, doi:<a href=\"https://doi.org/10.1007/s10858-012-9659-9\">10.1007/s10858-012-9659-9</a>.","ista":"Asami S, Szekely K, Schanda P, Meier BH, Reif B. 2012. Optimal degree of protonation for 1H detection of aliphatic sites in randomly deuterated proteins as a function of the MAS frequency. Journal of Biomolecular NMR. 54(2), 155–168."},"day":"23","extern":"1","author":[{"last_name":"Asami","full_name":"Asami, Sam","first_name":"Sam"},{"full_name":"Szekely, Kathrin","first_name":"Kathrin","last_name":"Szekely"},{"last_name":"Schanda","orcid":"0000-0002-9350-7606","first_name":"Paul","full_name":"Schanda, Paul","id":"7B541462-FAF6-11E9-A490-E8DFE5697425"},{"last_name":"Meier","full_name":"Meier, Beat H.","first_name":"Beat H."},{"full_name":"Reif, Bernd","first_name":"Bernd","last_name":"Reif"}],"type":"journal_article","month":"08"}]