[{"user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","type":"journal_article","volume":22,"page":"R635 - R637","year":"2012","publication_status":"published","intvolume":"        22","_id":"2458","issue":"16","day":"21","status":"public","month":"08","language":[{"iso":"eng"}],"citation":{"ama":"Li H, Friml J, Grunewald W. Cell polarity: Stretching prevents developmental cramps. <i>Current Biology</i>. 2012;22(16):R635-R637. doi:<a href=\"https://doi.org/10.1016/j.cub.2012.06.053\">10.1016/j.cub.2012.06.053</a>","mla":"Li, Hongjiang, et al. “Cell Polarity: Stretching Prevents Developmental Cramps.” <i>Current Biology</i>, vol. 22, no. 16, Cell Press, 2012, pp. R635–37, doi:<a href=\"https://doi.org/10.1016/j.cub.2012.06.053\">10.1016/j.cub.2012.06.053</a>.","short":"H. Li, J. Friml, W. Grunewald, Current Biology 22 (2012) R635–R637.","ista":"Li H, Friml J, Grunewald W. 2012. Cell polarity: Stretching prevents developmental cramps. Current Biology. 22(16), R635–R637.","chicago":"Li, Hongjiang, Jiří Friml, and Wim Grunewald. “Cell Polarity: Stretching Prevents Developmental Cramps.” <i>Current Biology</i>. Cell Press, 2012. <a href=\"https://doi.org/10.1016/j.cub.2012.06.053\">https://doi.org/10.1016/j.cub.2012.06.053</a>.","ieee":"H. Li, J. Friml, and W. Grunewald, “Cell polarity: Stretching prevents developmental cramps,” <i>Current Biology</i>, vol. 22, no. 16. Cell Press, pp. R635–R637, 2012.","apa":"Li, H., Friml, J., &#38; Grunewald, W. (2012). Cell polarity: Stretching prevents developmental cramps. <i>Current Biology</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.cub.2012.06.053\">https://doi.org/10.1016/j.cub.2012.06.053</a>"},"publisher":"Cell Press","publication":"Current Biology","title":"Cell polarity: Stretching prevents developmental cramps","publist_id":"4445","date_created":"2018-12-11T11:57:47Z","oa_version":"None","date_updated":"2021-01-12T06:57:36Z","doi":"10.1016/j.cub.2012.06.053","date_published":"2012-08-21T00:00:00Z","author":[{"last_name":"Li","orcid":"0000-0001-5039-9660","first_name":"Hongjiang","id":"33CA54A6-F248-11E8-B48F-1D18A9856A87","full_name":"Li, Hongjiang"},{"first_name":"Jirí","last_name":"Friml","orcid":"0000-0002-8302-7596","full_name":"Friml, Jirí","id":"4159519E-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Grunewald, Wim","last_name":"Grunewald","first_name":"Wim"}],"quality_controlled":"1","extern":"1","abstract":[{"text":"Initiation and successive development of organs induce mechanical stresses at the cellular level. Using the tomato shoot apex, a new study now proposes that mechanical strain regulates the plasma membrane abundance of the PIN1 auxin transporter, thereby reinforcing a positive feed-back loop between growth and auxin accumulation.","lang":"eng"}]},{"user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","type":"journal_article","volume":3,"year":"2012","has_accepted_license":"1","_id":"2459","issue":"May","oa":1,"status":"public","citation":{"mla":"Zwiewka, Marta, and Jiří Friml. “Fluorescence Imaging-Based Forward Genetic Screens to Identify Trafficking Regulators in Plants.” <i>Frontiers in Plant Science</i>, vol. 3, no. May, 97, Frontiers Research Foundation, 2012, doi:<a href=\"https://doi.org/10.3389/fpls.2012.00097\">10.3389/fpls.2012.00097</a>.","ista":"Zwiewka M, Friml J. 2012. Fluorescence imaging-based forward genetic screens to identify trafficking regulators in plants. Frontiers in Plant Science. 3(May), 97.","short":"M. Zwiewka, J. Friml, Frontiers in Plant Science 3 (2012).","ama":"Zwiewka M, Friml J. Fluorescence imaging-based forward genetic screens to identify trafficking regulators in plants. <i>Frontiers in Plant Science</i>. 2012;3(May). doi:<a href=\"https://doi.org/10.3389/fpls.2012.00097\">10.3389/fpls.2012.00097</a>","apa":"Zwiewka, M., &#38; Friml, J. (2012). Fluorescence imaging-based forward genetic screens to identify trafficking regulators in plants. <i>Frontiers in Plant Science</i>. Frontiers Research Foundation. <a href=\"https://doi.org/10.3389/fpls.2012.00097\">https://doi.org/10.3389/fpls.2012.00097</a>","chicago":"Zwiewka, Marta, and Jiří Friml. “Fluorescence Imaging-Based Forward Genetic Screens to Identify Trafficking Regulators in Plants.” <i>Frontiers in Plant Science</i>. Frontiers Research Foundation, 2012. <a href=\"https://doi.org/10.3389/fpls.2012.00097\">https://doi.org/10.3389/fpls.2012.00097</a>.","ieee":"M. Zwiewka and J. Friml, “Fluorescence imaging-based forward genetic screens to identify trafficking regulators in plants,” <i>Frontiers in Plant Science</i>, vol. 3, no. May. Frontiers Research Foundation, 2012."},"publisher":"Frontiers Research Foundation","publication":"Frontiers in Plant Science","title":"Fluorescence imaging-based forward genetic screens to identify trafficking regulators in plants","publist_id":"4444","date_created":"2018-12-11T11:57:47Z","oa_version":"Published Version","extern":"1","abstract":[{"text":"Coordinated, subcellular trafficking of proteins is one of the fundamental properties of the multicellular eukaryotic organisms. Trafficking involves a large diversity of compartments, pathways, cargo molecules, and vesicle-sorting events. It is also crucial in regulating the localization and, thus, the activity of various proteins, but the process is still poorly genetically defined in plants. In the past, forward genetics screens had been used to determine the function of genes by searching for a specific morphological phenotype in the organism population in which mutations had been induced chemically or by irradiation. Unfortunately, these straightforward genetic screens turned out to be limited in identifying new regulators of intracellular protein transport, because mutations affecting essential trafficking pathways often lead to lethality. In addition, the use of these approaches has been restricted by functional redundancy among trafficking regulators. Screens for mutants that rely on the observation of changes in the cellular localization or dynamics of fluorescent subcellular markers enable, at least partially, to circumvent these issues. Hence, such image-based screens provide the possibility to identify either alleles with weak effects or components of the subcellular trafficking machinery that have no strong impact on the plant growth.","lang":"eng"}],"license":"https://creativecommons.org/licenses/by-nc/4.0/","file":[{"content_type":"application/pdf","date_created":"2019-04-26T06:49:26Z","relation":"main_file","access_level":"open_access","creator":"kschuh","file_size":1468230,"checksum":"ab4e9487ccdb83a7a0a9ee6811521844","file_name":"2012_frontiers_Zwiewka.pdf","file_id":"6346","date_updated":"2020-07-14T12:45:41Z"}],"publication_status":"published","intvolume":"         3","ddc":["580"],"day":"24","month":"05","language":[{"iso":"eng"}],"article_number":"97","file_date_updated":"2020-07-14T12:45:41Z","tmp":{"short":"CC BY-NC (4.0)","image":"/images/cc_by_nc.png","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)"},"date_updated":"2021-01-12T06:57:36Z","doi":"10.3389/fpls.2012.00097","date_published":"2012-05-24T00:00:00Z","author":[{"first_name":"Marta","last_name":"Zwiewka","full_name":"Zwiewka, Marta"},{"first_name":"Jirí","orcid":"0000-0002-8302-7596","last_name":"Friml","full_name":"Friml, Jirí","id":"4159519E-F248-11E8-B48F-1D18A9856A87"}],"quality_controlled":"1"},{"publist_id":"4427","date_created":"2018-12-11T11:57:52Z","publisher":"Elsevier","publication":"Neuron","title":"Thin dendrites of cerebellar interneurons confer sublinear synaptic integration and a gradient of short-term plasticity","extern":1,"quality_controlled":0,"abstract":[{"lang":"eng","text":"Interneurons are critical for neuronal circuit function, but how their dendritic morphologies and membrane properties influence information flow within neuronal circuits is largely unknown. We studied the spatiotemporal profile of synaptic integration and short-term plasticity in dendrites of mature cerebellar stellate cells by combining two-photon guided electrical stimulation, glutamate uncaging, electron microscopy, and modeling. Synaptic activation within thin (0.4 μm) dendrites produced somatic responses that became smaller and slower with increasing distance from the soma, sublinear subthreshold input-output relationships, and a somatodendritic gradient of short-term plasticity. Unlike most studies showing that neurons employ active dendritic mechanisms, we found that passive cable properties of thin dendrites determine the sublinear integration and plasticity gradient, which both result from large dendritic depolarizations that reduce synaptic driving force. These integrative properties allow stellate cells to act as spatiotemporal filters of synaptic input patterns, thereby biasing their output in favor of sparse presynaptic activity. Stellate cells are critical sources of inhibition in the cerebellum, but how their dendrites integrate excitatory synaptic inputs is unknown. Abrahamsson et al. show that thin dendrites and passive membrane properties of SCs promote sublinear synaptic summation and distance-dependent short-term plasticity. "}],"date_updated":"2021-01-12T06:57:42Z","doi":"10.1016/j.neuron.2012.01.027","author":[{"full_name":"Abrahamsson, Therese","first_name":"Therese","last_name":"Abrahamsson"},{"full_name":"Cathala, Laurence","first_name":"Laurence","last_name":"Cathala"},{"full_name":"Matsui, Ko","first_name":"Ko","last_name":"Matsui"},{"first_name":"Ryuichi","last_name":"Shigemoto","orcid":"0000-0001-8761-9444","full_name":"Ryuichi Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Digregorio","first_name":"David","full_name":"DiGregorio, David A"}],"date_published":"2012-03-22T00:00:00Z","year":"2012","publication_status":"published","_id":"2474","intvolume":"        73","type":"journal_article","volume":73,"page":"1159 - 1172","month":"03","citation":{"ama":"Abrahamsson T, Cathala L, Matsui K, Shigemoto R, Digregorio D. Thin dendrites of cerebellar interneurons confer sublinear synaptic integration and a gradient of short-term plasticity. <i>Neuron</i>. 2012;73(6):1159-1172. doi:<a href=\"https://doi.org/10.1016/j.neuron.2012.01.027\">10.1016/j.neuron.2012.01.027</a>","short":"T. Abrahamsson, L. Cathala, K. Matsui, R. Shigemoto, D. Digregorio, Neuron 73 (2012) 1159–1172.","mla":"Abrahamsson, Therese, et al. “Thin Dendrites of Cerebellar Interneurons Confer Sublinear Synaptic Integration and a Gradient of Short-Term Plasticity.” <i>Neuron</i>, vol. 73, no. 6, Elsevier, 2012, pp. 1159–72, doi:<a href=\"https://doi.org/10.1016/j.neuron.2012.01.027\">10.1016/j.neuron.2012.01.027</a>.","ista":"Abrahamsson T, Cathala L, Matsui K, Shigemoto R, Digregorio D. 2012. Thin dendrites of cerebellar interneurons confer sublinear synaptic integration and a gradient of short-term plasticity. Neuron. 73(6), 1159–1172.","chicago":"Abrahamsson, Therese, Laurence Cathala, Ko Matsui, Ryuichi Shigemoto, and David Digregorio. “Thin Dendrites of Cerebellar Interneurons Confer Sublinear Synaptic Integration and a Gradient of Short-Term Plasticity.” <i>Neuron</i>. Elsevier, 2012. <a href=\"https://doi.org/10.1016/j.neuron.2012.01.027\">https://doi.org/10.1016/j.neuron.2012.01.027</a>.","ieee":"T. Abrahamsson, L. Cathala, K. Matsui, R. Shigemoto, and D. Digregorio, “Thin dendrites of cerebellar interneurons confer sublinear synaptic integration and a gradient of short-term plasticity,” <i>Neuron</i>, vol. 73, no. 6. Elsevier, pp. 1159–1172, 2012.","apa":"Abrahamsson, T., Cathala, L., Matsui, K., Shigemoto, R., &#38; Digregorio, D. (2012). Thin dendrites of cerebellar interneurons confer sublinear synaptic integration and a gradient of short-term plasticity. <i>Neuron</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.neuron.2012.01.027\">https://doi.org/10.1016/j.neuron.2012.01.027</a>"},"issue":"6","day":"22","status":"public"},{"type":"journal_article","volume":7,"year":"2012","publication_status":"published","_id":"2475","intvolume":"         7","issue":"1","day":"03","status":"public","month":"10","citation":{"apa":"Saito, Y., Inoue, T., Zhu, G., Kimura, N., Okada, M., Nishimura, M., … Suzuki, T. (2012). Hyperpolarization-activated cyclic nucleotide gated channels: A potential molecular link between epileptic seizures and Aβ generation in Alzheimer’s disease. <i>Molecular Neurodegeneration</i>. BioMed Central. <a href=\"https://doi.org/10.1186/1750-1326-7-50\">https://doi.org/10.1186/1750-1326-7-50</a>","chicago":"Saito, Yuhki, Tsuyoshi Inoue, Gang Zhu, Naoki Kimura, Motohiro Okada, Masaki Nishimura, Shigeo Murayama, et al. “Hyperpolarization-Activated Cyclic Nucleotide Gated Channels: A Potential Molecular Link between Epileptic Seizures and Aβ Generation in Alzheimer’s Disease.” <i>Molecular Neurodegeneration</i>. BioMed Central, 2012. <a href=\"https://doi.org/10.1186/1750-1326-7-50\">https://doi.org/10.1186/1750-1326-7-50</a>.","ieee":"Y. Saito <i>et al.</i>, “Hyperpolarization-activated cyclic nucleotide gated channels: A potential molecular link between epileptic seizures and Aβ generation in Alzheimer’s disease,” <i>Molecular Neurodegeneration</i>, vol. 7, no. 1. BioMed Central, 2012.","ista":"Saito Y, Inoue T, Zhu G, Kimura N, Okada M, Nishimura M, Murayama S, Kaneko S, Shigemoto R, Imoto K, Suzuki T. 2012. Hyperpolarization-activated cyclic nucleotide gated channels: A potential molecular link between epileptic seizures and Aβ generation in Alzheimer’s disease. Molecular Neurodegeneration. 7(1).","short":"Y. Saito, T. Inoue, G. Zhu, N. Kimura, M. Okada, M. Nishimura, S. Murayama, S. Kaneko, R. Shigemoto, K. Imoto, T. Suzuki, Molecular Neurodegeneration 7 (2012).","mla":"Saito, Yuhki, et al. “Hyperpolarization-Activated Cyclic Nucleotide Gated Channels: A Potential Molecular Link between Epileptic Seizures and Aβ Generation in Alzheimer’s Disease.” <i>Molecular Neurodegeneration</i>, vol. 7, no. 1, BioMed Central, 2012, doi:<a href=\"https://doi.org/10.1186/1750-1326-7-50\">10.1186/1750-1326-7-50</a>.","ama":"Saito Y, Inoue T, Zhu G, et al. Hyperpolarization-activated cyclic nucleotide gated channels: A potential molecular link between epileptic seizures and Aβ generation in Alzheimer’s disease. <i>Molecular Neurodegeneration</i>. 2012;7(1). doi:<a href=\"https://doi.org/10.1186/1750-1326-7-50\">10.1186/1750-1326-7-50</a>"},"publisher":"BioMed Central","publication":"Molecular Neurodegeneration","title":"Hyperpolarization-activated cyclic nucleotide gated channels: A potential molecular link between epileptic seizures and Aβ generation in Alzheimer's disease","publist_id":"4426","date_created":"2018-12-11T11:57:53Z","doi":"10.1186/1750-1326-7-50","date_updated":"2021-01-12T06:57:42Z","date_published":"2012-10-03T00:00:00Z","author":[{"last_name":"Saito","first_name":"Yuhki","full_name":"Saito, Yuhki"},{"first_name":"Tsuyoshi","last_name":"Inoue","full_name":"Inoue, Tsuyoshi"},{"first_name":"Gang","last_name":"Zhu","full_name":"Zhu, Gang"},{"full_name":"Kimura, Naoki","first_name":"Naoki","last_name":"Kimura"},{"first_name":"Motohiro","last_name":"Okada","full_name":"Okada, Motohiro"},{"full_name":"Nishimura, Masaki","last_name":"Nishimura","first_name":"Masaki"},{"full_name":"Murayama, Shigeo","first_name":"Shigeo","last_name":"Murayama"},{"last_name":"Kaneko","first_name":"Sunao","full_name":"Kaneko, Sunao"},{"first_name":"Ryuichi","orcid":"0000-0001-8761-9444","last_name":"Shigemoto","full_name":"Ryuichi Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Imoto, Keiji","first_name":"Keiji","last_name":"Imoto"},{"first_name":"Toshiharu","last_name":"Suzuki","full_name":"Suzuki, Toshiharu"}],"quality_controlled":0,"extern":1,"abstract":[{"text":"Background: One of the best-characterized causative factors of Alzheimer's disease (AD) is the generation of amyloid-β peptide (Aβ). AD subjects are at high risk of epileptic seizures accompanied by aberrant neuronal excitability, which in itself enhances Aβ generation. However, the molecular linkage between epileptic seizures and Aβ generation in AD remains unclear. Results: X11 and X11-like (X11L) gene knockout mice suffered from epileptic seizures, along with a malfunction of hyperpolarization-activated cyclic nucleotide gated (HCN) channels. Genetic ablation of HCN1 in mice and HCN1 channel blockage in cultured Neuro2a (N2a) cells enhanced Aβ generation. Interestingly, HCN1 levels dramatically decreased in the temporal lobe of cynomolgus monkeys (Macaca fascicularis) during aging and were significantly diminished in the temporal lobe of sporadic AD patients. Conclusion: Because HCN1 associates with amyloid-β precursor protein (APP) and X11/X11L in the brain, genetic deficiency of X11/X11L may induce aberrant HCN1 distribution along with epilepsy. Moreover, the reduction in HCN1 levels in aged primates may contribute to augmented Aβ generation. Taken together, HCN1 is proposed to play an important role in the molecular linkage between epileptic seizures and Aβ generation, and in the aggravation of sporadic AD.","lang":"eng"}]},{"publication":"Journal of Physiology","title":"Virus-mediated swapping of zolpidem-insensitive with zolpidem-sensitive GABA A receptors in cortical pyramidal cells","publisher":"Wiley-Blackwell","date_created":"2018-12-11T11:57:53Z","publist_id":"4425","author":[{"full_name":"Sümegi, Máté","first_name":"Máté","last_name":"Sümegi"},{"full_name":"Fukazawa, Yugo","first_name":"Yugo","last_name":"Fukazawa"},{"first_name":"Ko","last_name":"Matsui","full_name":"Matsui, Ko"},{"full_name":"Lörincz, Andrea","last_name":"Lörincz","first_name":"Andrea"},{"first_name":"Mark","last_name":"Eyre","full_name":"Eyre, Mark D"},{"last_name":"Nusser","first_name":"Zoltán","full_name":"Nusser, Zoltán"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Ryuichi Shigemoto","orcid":"0000-0001-8761-9444","last_name":"Shigemoto","first_name":"Ryuichi"}],"date_published":"2012-04-07T00:00:00Z","doi":"10.1113/jphysiol.2012.227538","date_updated":"2021-01-12T06:57:43Z","abstract":[{"lang":"eng","text":"Recently developed pharmacogenetic and optogenetic approaches, with their own advantages and disadvantages, have become indispensable tools in modern neuroscience. Here, we employed a previously described knock-in mouse line (GABA ARγ2 77Ilox) in which the γ2 subunit of the GABA A receptor (GABA AR) was mutated to become zolpidem insensitive (γ2 77I) and used viral vectors to swap γ2 77I with wild-type, zolpidem-sensitive γ2 subunits (γ2 77F). The verification of unaltered density and subcellular distribution of the virally introduced γ2 subunits requires their selective labelling. For this we generated six N- and six C-terminal-tagged γ2 subunits, with which cortical cultures of GABA ARγ2 -/- mice were transduced using lentiviruses. We found that the N-terminal AU1 tag resulted in excellent immunodetection and unimpaired synaptic localization. Unaltered kinetic properties of the AU1-tagged γ2 ( AU1γ2 77F) channels were demonstrated with whole-cell patch-clamp recordings of spontaneous IPSCs from cultured cells. Next, we carried out stereotaxic injections of lenti- and adeno-associated viruses containing Cre-recombinase and the AU1γ2 77F subunit (Cre-2A- AU1γ2 77F) into the neocortex of GABA ARγ2 77Ilox mice. Light microscopic immunofluorescence and electron microscopic freeze-fracture replica immunogold labelling demonstrated the efficient immunodetection of the AU1 tag and the normal enrichment of the AU1γ2 77F subunits in perisomatic GABAergic synapses. In line with this, miniature and action potential-evoked IPSCs whole-cell recorded from transduced cells had unaltered amplitudes, kinetics and restored zolpidem sensitivity. Our results obtained with a wide range of structural and functional verification methods reveal unaltered subcellular distributions and functional properties of γ2 77I and AU1γ2 77F GABA ARs in cortical pyramidal cells. This transgenic-viral pharmacogenetic approach has the advantage that it does not require any extrinsic protein that might endow some unforeseen alterations of the genetically modified cells. In addition, this virus-based approach opens up the possibility of modifying multiple cell types in distinct brain regions and performing alternative recombination-based intersectional genetic manipulations."}],"extern":1,"quality_controlled":0,"volume":590,"page":"1517 - 1534","type":"journal_article","intvolume":"       590","_id":"2476","year":"2012","publication_status":"published","status":"public","issue":"7","day":"07","citation":{"ista":"Sümegi M, Fukazawa Y, Matsui K, Lörincz A, Eyre M, Nusser Z, Shigemoto R. 2012. Virus-mediated swapping of zolpidem-insensitive with zolpidem-sensitive GABA A receptors in cortical pyramidal cells. Journal of Physiology. 590(7), 1517–1534.","mla":"Sümegi, Máté, et al. “Virus-Mediated Swapping of Zolpidem-Insensitive with Zolpidem-Sensitive GABA A Receptors in Cortical Pyramidal Cells.” <i>Journal of Physiology</i>, vol. 590, no. 7, Wiley-Blackwell, 2012, pp. 1517–34, doi:<a href=\"https://doi.org/10.1113/jphysiol.2012.227538\">10.1113/jphysiol.2012.227538</a>.","short":"M. Sümegi, Y. Fukazawa, K. Matsui, A. Lörincz, M. Eyre, Z. Nusser, R. Shigemoto, Journal of Physiology 590 (2012) 1517–1534.","ama":"Sümegi M, Fukazawa Y, Matsui K, et al. Virus-mediated swapping of zolpidem-insensitive with zolpidem-sensitive GABA A receptors in cortical pyramidal cells. <i>Journal of Physiology</i>. 2012;590(7):1517-1534. doi:<a href=\"https://doi.org/10.1113/jphysiol.2012.227538\">10.1113/jphysiol.2012.227538</a>","apa":"Sümegi, M., Fukazawa, Y., Matsui, K., Lörincz, A., Eyre, M., Nusser, Z., &#38; Shigemoto, R. (2012). Virus-mediated swapping of zolpidem-insensitive with zolpidem-sensitive GABA A receptors in cortical pyramidal cells. <i>Journal of Physiology</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1113/jphysiol.2012.227538\">https://doi.org/10.1113/jphysiol.2012.227538</a>","ieee":"M. Sümegi <i>et al.</i>, “Virus-mediated swapping of zolpidem-insensitive with zolpidem-sensitive GABA A receptors in cortical pyramidal cells,” <i>Journal of Physiology</i>, vol. 590, no. 7. Wiley-Blackwell, pp. 1517–1534, 2012.","chicago":"Sümegi, Máté, Yugo Fukazawa, Ko Matsui, Andrea Lörincz, Mark Eyre, Zoltán Nusser, and Ryuichi Shigemoto. “Virus-Mediated Swapping of Zolpidem-Insensitive with Zolpidem-Sensitive GABA A Receptors in Cortical Pyramidal Cells.” <i>Journal of Physiology</i>. Wiley-Blackwell, 2012. <a href=\"https://doi.org/10.1113/jphysiol.2012.227538\">https://doi.org/10.1113/jphysiol.2012.227538</a>."},"month":"04"},{"quality_controlled":0,"extern":1,"abstract":[{"lang":"eng","text":"Dynamic activity of glia has repeatedly been demonstrated, but if such activity is independent from neuronal activity, glia would not have any role in the information processing in the brain or in the generation of animal behavior. Evidence for neurons communicating with glia is solid, but the signaling pathway leading back from glial-to-neuronal activity was often difficult to study. Here, we introduced a transgenic mouse line in which channelrhodopsin-2, a light-gated cation channel, was expressed in astrocytes. Selective photostimulation of these astrocytes in vivo triggered neuronal activation. Using slice preparations, we show that glial photostimulation leads to release of glutamate, which was sufficient to activate AMPA receptors on Purkinje cells and to induce long-term depression of parallel fiber-to-Purkinje cell synapses through activation of metabotropic glutamate receptors. In contrast to neuronal synaptic vesicular release, glial activation likely causes preferential activation of extrasynaptic receptors that appose glial membrane. Finally, we show that neuronal activation by glial stimulation can lead to perturbation of cerebellar modulated motor behavior. These findings demonstrate that glia can modulate the tone of neuronal activity and behavior. This animal model is expected to be a potentially powerful approach to study the role of glia in brain function."}],"date_updated":"2021-01-12T06:57:43Z","doi":"10.1073/pnas.1213458109","date_published":"2012-12-11T00:00:00Z","author":[{"full_name":"Sasaki, Takuya","first_name":"Takuya","last_name":"Sasaki"},{"first_name":"Kaoru","last_name":"Beppu","full_name":"Beppu, Kaoru"},{"last_name":"Tanaka","first_name":"Kenji","full_name":"Tanaka, Kenji F"},{"last_name":"Fukazawa","first_name":"Yugo","full_name":"Fukazawa, Yugo"},{"full_name":"Ryuichi Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","last_name":"Shigemoto","orcid":"0000-0001-8761-9444"},{"full_name":"Matsui, Ko","first_name":"Ko","last_name":"Matsui"}],"publist_id":"4424","date_created":"2018-12-11T11:57:54Z","publisher":"National Academy of Sciences","title":"Application of an optogenetic byway for perturbing neuronal activity via glial photostimulation","publication":"PNAS","month":"12","citation":{"mla":"Sasaki, Takuya, et al. “Application of an Optogenetic Byway for Perturbing Neuronal Activity via Glial Photostimulation.” <i>PNAS</i>, vol. 109, no. 50, National Academy of Sciences, 2012, pp. 20720–25, doi:<a href=\"https://doi.org/10.1073/pnas.1213458109\">10.1073/pnas.1213458109</a>.","short":"T. Sasaki, K. Beppu, K. Tanaka, Y. Fukazawa, R. Shigemoto, K. Matsui, PNAS 109 (2012) 20720–20725.","ista":"Sasaki T, Beppu K, Tanaka K, Fukazawa Y, Shigemoto R, Matsui K. 2012. Application of an optogenetic byway for perturbing neuronal activity via glial photostimulation. PNAS. 109(50), 20720–20725.","ama":"Sasaki T, Beppu K, Tanaka K, Fukazawa Y, Shigemoto R, Matsui K. Application of an optogenetic byway for perturbing neuronal activity via glial photostimulation. <i>PNAS</i>. 2012;109(50):20720-20725. doi:<a href=\"https://doi.org/10.1073/pnas.1213458109\">10.1073/pnas.1213458109</a>","apa":"Sasaki, T., Beppu, K., Tanaka, K., Fukazawa, Y., Shigemoto, R., &#38; Matsui, K. (2012). Application of an optogenetic byway for perturbing neuronal activity via glial photostimulation. <i>PNAS</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.1213458109\">https://doi.org/10.1073/pnas.1213458109</a>","ieee":"T. Sasaki, K. Beppu, K. Tanaka, Y. Fukazawa, R. Shigemoto, and K. Matsui, “Application of an optogenetic byway for perturbing neuronal activity via glial photostimulation,” <i>PNAS</i>, vol. 109, no. 50. National Academy of Sciences, pp. 20720–20725, 2012.","chicago":"Sasaki, Takuya, Kaoru Beppu, Kenji Tanaka, Yugo Fukazawa, Ryuichi Shigemoto, and Ko Matsui. “Application of an Optogenetic Byway for Perturbing Neuronal Activity via Glial Photostimulation.” <i>PNAS</i>. National Academy of Sciences, 2012. <a href=\"https://doi.org/10.1073/pnas.1213458109\">https://doi.org/10.1073/pnas.1213458109</a>."},"day":"11","issue":"50","status":"public","publication_status":"published","year":"2012","_id":"2477","intvolume":"       109","type":"journal_article","page":"20720 - 20725","volume":109},{"extern":1,"quality_controlled":0,"abstract":[{"lang":"eng","text":"Visual information must be relayed through the lateral geniculate nucleus before it reaches the visual cortex. However, not all spikes created in the retina lead to postsynaptic spikes and properties of the retinogeniculate synapse contribute to this filtering. To understand the mechanisms underlying this filtering process, we conducted electrophysiology to assess the properties of signal transmission in the Long-Evans rat. We also performed SDS-digested freeze-fracture replica labeling to quantify the receptor and transporter distribution, as well as EM reconstruction to describe the 3D structure. To analyze the impact of transmitter diffusion on the activity of the receptors, simulations were integrated. We identified that a large contributor to the filtering is the marked paired-pulse depression at this synapse, which was intensified by the morphological characteristics of the contacts. The broad presynaptic and postsynaptic contact area restricts transmitter diffusion two dimensionally. Additionally, the presence of multiple closely arranged release sites invites intersynaptic spillover, which causes desensitization of AMPA receptors. The presence of AMPA receptors that slowly recover from desensitization along with the high presynaptic release probability and multivesicular release at each synapse also contribute to the depression. These features contrast with many other synapses where spatiotemporal spread of transmitter is limited by rapid transmitter clearance allowing synapses to operate more independently. We propose that the micrometer-order structure can ultimately affect the visual information processing."}],"doi":"10.1523/JNEUROSCI.5243-11.2012","date_updated":"2021-01-12T06:57:57Z","author":[{"full_name":"Budisantoso, Timotheus","first_name":"Timotheus","last_name":"Budisantoso"},{"full_name":"Matsui, Ko","last_name":"Matsui","first_name":"Ko"},{"first_name":"Naomi","last_name":"Kamasawa","full_name":"Kamasawa, Naomi"},{"last_name":"Fukazawa","first_name":"Yugo","full_name":"Fukazawa, Yugo"},{"first_name":"Ryuichi","last_name":"Shigemoto","orcid":"0000-0001-8761-9444","full_name":"Ryuichi Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"}],"date_published":"2012-02-15T00:00:00Z","publist_id":"4387","date_created":"2018-12-11T11:58:07Z","publisher":"Society for Neuroscience","publication":"Journal of Neuroscience","title":"Mechanisms underlying signal filtering at a multisynapse contact","month":"02","citation":{"apa":"Budisantoso, T., Matsui, K., Kamasawa, N., Fukazawa, Y., &#38; Shigemoto, R. (2012). Mechanisms underlying signal filtering at a multisynapse contact. <i>Journal of Neuroscience</i>. Society for Neuroscience. <a href=\"https://doi.org/10.1523/JNEUROSCI.5243-11.2012\">https://doi.org/10.1523/JNEUROSCI.5243-11.2012</a>","ieee":"T. Budisantoso, K. Matsui, N. Kamasawa, Y. Fukazawa, and R. Shigemoto, “Mechanisms underlying signal filtering at a multisynapse contact,” <i>Journal of Neuroscience</i>, vol. 32, no. 7. Society for Neuroscience, pp. 2357–2376, 2012.","chicago":"Budisantoso, Timotheus, Ko Matsui, Naomi Kamasawa, Yugo Fukazawa, and Ryuichi Shigemoto. “Mechanisms Underlying Signal Filtering at a Multisynapse Contact.” <i>Journal of Neuroscience</i>. Society for Neuroscience, 2012. <a href=\"https://doi.org/10.1523/JNEUROSCI.5243-11.2012\">https://doi.org/10.1523/JNEUROSCI.5243-11.2012</a>.","mla":"Budisantoso, Timotheus, et al. “Mechanisms Underlying Signal Filtering at a Multisynapse Contact.” <i>Journal of Neuroscience</i>, vol. 32, no. 7, Society for Neuroscience, 2012, pp. 2357–76, doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.5243-11.2012\">10.1523/JNEUROSCI.5243-11.2012</a>.","ista":"Budisantoso T, Matsui K, Kamasawa N, Fukazawa Y, Shigemoto R. 2012. Mechanisms underlying signal filtering at a multisynapse contact. Journal of Neuroscience. 32(7), 2357–2376.","short":"T. Budisantoso, K. Matsui, N. Kamasawa, Y. Fukazawa, R. Shigemoto, Journal of Neuroscience 32 (2012) 2357–2376.","ama":"Budisantoso T, Matsui K, Kamasawa N, Fukazawa Y, Shigemoto R. Mechanisms underlying signal filtering at a multisynapse contact. <i>Journal of Neuroscience</i>. 2012;32(7):2357-2376. doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.5243-11.2012\">10.1523/JNEUROSCI.5243-11.2012</a>"},"issue":"7","day":"15","status":"public","year":"2012","publication_status":"published","_id":"2514","intvolume":"        32","type":"journal_article","volume":32,"page":"2357 - 2376"},{"month":"06","citation":{"ama":"Ballesteros Merino C, Lin M, Wu W, et al.  Developmental profile of SK2 channel expression and function in CA1 neurons. <i>Hippocampus</i>. 2012;22(6):1467-1480. doi:<a href=\"https://doi.org/10.1002/hipo.20986\">10.1002/hipo.20986</a>","ista":"Ballesteros Merino C, Lin M, Wu W, Ferrándiz Huertas C, Cabañero M, Watanabe M, Fukazawa Y, Shigemoto R, Maylie J, Adelman J, Luján R. 2012.  Developmental profile of SK2 channel expression and function in CA1 neurons. Hippocampus. 22(6), 1467–1480.","mla":"Ballesteros Merino, Carmen, et al. “ Developmental Profile of SK2 Channel Expression and Function in CA1 Neurons.” <i>Hippocampus</i>, vol. 22, no. 6, Wiley-Blackwell, 2012, pp. 1467–80, doi:<a href=\"https://doi.org/10.1002/hipo.20986\">10.1002/hipo.20986</a>.","short":"C. Ballesteros Merino, M. Lin, W. Wu, C. Ferrándiz Huertas, M. Cabañero, M. Watanabe, Y. Fukazawa, R. Shigemoto, J. Maylie, J. Adelman, R. Luján, Hippocampus 22 (2012) 1467–1480.","ieee":"C. Ballesteros Merino <i>et al.</i>, “ Developmental profile of SK2 channel expression and function in CA1 neurons,” <i>Hippocampus</i>, vol. 22, no. 6. Wiley-Blackwell, pp. 1467–1480, 2012.","chicago":"Ballesteros Merino, Carmen, Michael Lin, Wendy Wu, Clotilde Ferrándiz Huertas, María Cabañero, Masahiko Watanabe, Yugo Fukazawa, et al. “ Developmental Profile of SK2 Channel Expression and Function in CA1 Neurons.” <i>Hippocampus</i>. Wiley-Blackwell, 2012. <a href=\"https://doi.org/10.1002/hipo.20986\">https://doi.org/10.1002/hipo.20986</a>.","apa":"Ballesteros Merino, C., Lin, M., Wu, W., Ferrándiz Huertas, C., Cabañero, M., Watanabe, M., … Luján, R. (2012).  Developmental profile of SK2 channel expression and function in CA1 neurons. <i>Hippocampus</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1002/hipo.20986\">https://doi.org/10.1002/hipo.20986</a>"},"day":"01","issue":"6","status":"public","publication_status":"published","year":"2012","intvolume":"        22","_id":"2515","type":"journal_article","page":"1467 - 1480","volume":22,"extern":1,"quality_controlled":0,"abstract":[{"lang":"eng","text":"We investigated the temporal and spatial expression of SK2 in the developing mouse hippocampus using molecular and biochemical techniques, quantitative immunogold electron microscopy, and electrophysiology. The mRNA encoding SK2 was expressed in the developing and adult hippocampus. Western blotting and immunohistochemistry showed that SK2 protein increased with age. This was accompanied by a shift in subcellular localization. Early in development (P5), SK2 was predominantly localized to the endoplasmic reticulum in the pyramidal cell layer. But by P30 SK2 was almost exclusively expressed in the dendrites and spines. The level of SK2 at the postsynaptic density (PSD) also increased during development. In the adult, SK2 expression on the spine plasma membrane showed a proximal-to-distal gradient. Consistent with this redistribution and gradient of SK2, the selective SK channel blocker apamin increased evoked excitatory postsynaptic potentials (EPSPs) only in CA1 pyramidal neurons from mice older than P15. However, the effect of apamin on EPSPs was not different between synapses in proximal or distal stratum radiatum or stratum lacunosum-moleculare in adult. These results show a developmental increase and gradient in SK2-containing channel surface expression that underlie their influence on neurotransmission, and that may contribute to increased memory acquisition during early development."}],"doi":"10.1002/hipo.20986","date_updated":"2021-01-12T06:57:57Z","date_published":"2012-06-01T00:00:00Z","author":[{"full_name":"Ballesteros-Merino, Carmen","first_name":"Carmen","last_name":"Ballesteros Merino"},{"last_name":"Lin","first_name":"Michael","full_name":"Lin, Michael"},{"first_name":"Wendy","last_name":"Wu","full_name":"Wu, Wendy W"},{"last_name":"Ferrándiz Huertas","first_name":"Clotilde","full_name":"Ferrándiz-Huertas, Clotilde"},{"first_name":"María","last_name":"Cabañero","full_name":"Cabañero, María José"},{"full_name":"Watanabe, Masahiko","first_name":"Masahiko","last_name":"Watanabe"},{"full_name":"Fukazawa, Yugo","last_name":"Fukazawa","first_name":"Yugo"},{"first_name":"Ryuichi","orcid":"0000-0001-8761-9444","last_name":"Shigemoto","full_name":"Ryuichi Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Maylie","first_name":"James","full_name":"Maylie, James G"},{"full_name":"Adelman, John P","last_name":"Adelman","first_name":"John"},{"full_name":"Luján, Rafael","first_name":"Rafael","last_name":"Luján"}],"publist_id":"4386","date_created":"2018-12-11T11:58:07Z","publisher":"Wiley-Blackwell","title":" Developmental profile of SK2 channel expression and function in CA1 neurons","publication":"Hippocampus"},{"day":"01","issue":"2","status":"public","month":"01","citation":{"apa":"Shinohara, Y., Hosoya, A., Yamasaki, N., Ahmed, H., Hattori, S., Eguchi, M., … Shigemoto, R. (2012). Right-hemispheric dominance of spatial memory in split-brain mice. <i>Hippocampus</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1002/hipo.20886\">https://doi.org/10.1002/hipo.20886</a>","ieee":"Y. Shinohara <i>et al.</i>, “Right-hemispheric dominance of spatial memory in split-brain mice,” <i>Hippocampus</i>, vol. 22, no. 2. Wiley-Blackwell, pp. 117–121, 2012.","chicago":"Shinohara, Yoshiaki, Aki Hosoya, Nobuyuki Yamasaki, Hassan Ahmed, Satoko Hattori, Megumi Eguchi, Shun Yamaguchi, Tsuyoshi Miyakawa, Hajime Hirase, and Ryuichi Shigemoto. “Right-Hemispheric Dominance of Spatial Memory in Split-Brain Mice.” <i>Hippocampus</i>. Wiley-Blackwell, 2012. <a href=\"https://doi.org/10.1002/hipo.20886\">https://doi.org/10.1002/hipo.20886</a>.","short":"Y. Shinohara, A. Hosoya, N. Yamasaki, H. Ahmed, S. Hattori, M. Eguchi, S. Yamaguchi, T. Miyakawa, H. Hirase, R. Shigemoto, Hippocampus 22 (2012) 117–121.","mla":"Shinohara, Yoshiaki, et al. “Right-Hemispheric Dominance of Spatial Memory in Split-Brain Mice.” <i>Hippocampus</i>, vol. 22, no. 2, Wiley-Blackwell, 2012, pp. 117–21, doi:<a href=\"https://doi.org/10.1002/hipo.20886\">10.1002/hipo.20886</a>.","ista":"Shinohara Y, Hosoya A, Yamasaki N, Ahmed H, Hattori S, Eguchi M, Yamaguchi S, Miyakawa T, Hirase H, Shigemoto R. 2012. Right-hemispheric dominance of spatial memory in split-brain mice. Hippocampus. 22(2), 117–121.","ama":"Shinohara Y, Hosoya A, Yamasaki N, et al. Right-hemispheric dominance of spatial memory in split-brain mice. <i>Hippocampus</i>. 2012;22(2):117-121. doi:<a href=\"https://doi.org/10.1002/hipo.20886\">10.1002/hipo.20886</a>"},"type":"journal_article","page":"117 - 121","volume":22,"publication_status":"published","year":"2012","_id":"2687","intvolume":"        22","date_updated":"2021-01-12T06:59:03Z","doi":"10.1002/hipo.20886","author":[{"full_name":"Shinohara, Yoshiaki","first_name":"Yoshiaki","last_name":"Shinohara"},{"first_name":"Aki","last_name":"Hosoya","full_name":"Hosoya, Aki"},{"last_name":"Yamasaki","first_name":"Nobuyuki","full_name":"Yamasaki, Nobuyuki"},{"last_name":"Ahmed","first_name":"Hassan","full_name":"Ahmed, Hassan"},{"full_name":"Hattori, Satoko","first_name":"Satoko","last_name":"Hattori"},{"full_name":"Eguchi, Megumi","last_name":"Eguchi","first_name":"Megumi"},{"last_name":"Yamaguchi","first_name":"Shun","full_name":"Yamaguchi, Shun"},{"first_name":"Tsuyoshi","last_name":"Miyakawa","full_name":"Miyakawa, Tsuyoshi"},{"full_name":"Hirase, Hajime","last_name":"Hirase","first_name":"Hajime"},{"last_name":"Shigemoto","orcid":"0000-0001-8761-9444","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Ryuichi Shigemoto"}],"date_published":"2012-01-01T00:00:00Z","quality_controlled":0,"extern":1,"abstract":[{"lang":"eng","text":"Left-right asymmetry of human brain function has been known for a century, although much of molecular and cellular basis of brain laterality remains to be elusive. Recent studies suggest that hippocampal CA3-CA1 excitatory synapses are asymmetrically arranged, however, the functional implication of the asymmetrical circuitry has not been studied at the behavioral level. In order to address the left-right asymmetry of hippocampal function in behaving mice, we analyzed the performance of &quot;split-brain&quot; mice in the Barnes maze. The &quot;split-brain&quot; mice received ventral hippocampal commissure and corpus callosum transection in addition to deprivation of visual input from one eye. In such mice, the hippocampus in the side of visual deprivation receives sensory-driven input. Better spatial task performance was achieved by the mice which were forced to use the right hippocampus than those which were forced to use the left hippocampus. In two-choice spatial maze, forced usage of left hippocampus resulted in a comparable performance to the right counterpart, suggesting that both hippocampal hemispheres are capable of conducting spatial learning. Therefore, the results obtained from the Barnes maze suggest that the usage of the right hippocampus improves the accuracy of spatial memory. Performance of non-spatial yet hippocampus-dependent tasks (e.g. fear conditioning) was not influenced by the laterality of the hippocampus."}],"publisher":"Wiley-Blackwell","title":"Right-hemispheric dominance of spatial memory in split-brain mice","publication":"Hippocampus","publist_id":"4210","date_created":"2018-12-11T11:59:04Z"},{"_id":"2688","intvolume":"        22","publication_status":"published","year":"2012","page":"446 - 452","volume":22,"type":"journal_article","citation":{"ama":"Fukazawa Y, Shigemoto R. Intra-synapse-type and inter-synapse-type relationships between synaptic size and AMPAR expression. <i>Current Opinion in Neurobiology</i>. 2012;22(3):446-452. doi:<a href=\"https://doi.org/10.1016/j.conb.2012.01.006\">10.1016/j.conb.2012.01.006</a>","ista":"Fukazawa Y, Shigemoto R. 2012. Intra-synapse-type and inter-synapse-type relationships between synaptic size and AMPAR expression. Current Opinion in Neurobiology. 22(3), 446–452.","short":"Y. Fukazawa, R. Shigemoto, Current Opinion in Neurobiology 22 (2012) 446–452.","mla":"Fukazawa, Yugo, and Ryuichi Shigemoto. “Intra-Synapse-Type and Inter-Synapse-Type Relationships between Synaptic Size and AMPAR Expression.” <i>Current Opinion in Neurobiology</i>, vol. 22, no. 3, Elsevier, 2012, pp. 446–52, doi:<a href=\"https://doi.org/10.1016/j.conb.2012.01.006\">10.1016/j.conb.2012.01.006</a>.","chicago":"Fukazawa, Yugo, and Ryuichi Shigemoto. “Intra-Synapse-Type and Inter-Synapse-Type Relationships between Synaptic Size and AMPAR Expression.” <i>Current Opinion in Neurobiology</i>. Elsevier, 2012. <a href=\"https://doi.org/10.1016/j.conb.2012.01.006\">https://doi.org/10.1016/j.conb.2012.01.006</a>.","ieee":"Y. Fukazawa and R. Shigemoto, “Intra-synapse-type and inter-synapse-type relationships between synaptic size and AMPAR expression,” <i>Current Opinion in Neurobiology</i>, vol. 22, no. 3. Elsevier, pp. 446–452, 2012.","apa":"Fukazawa, Y., &#38; Shigemoto, R. (2012). Intra-synapse-type and inter-synapse-type relationships between synaptic size and AMPAR expression. <i>Current Opinion in Neurobiology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.conb.2012.01.006\">https://doi.org/10.1016/j.conb.2012.01.006</a>"},"month":"06","status":"public","day":"01","issue":"3","date_created":"2018-12-11T11:59:04Z","publist_id":"4209","title":"Intra-synapse-type and inter-synapse-type relationships between synaptic size and AMPAR expression","publication":"Current Opinion in Neurobiology","publisher":"Elsevier","abstract":[{"lang":"eng","text":"To gain insights into structure-function relationship of excitatory synapses, we revisit our quantitative analysis of synaptic AMPAR by highly sensitive freeze-fracture replica labeling in eight different connections. All of these connections showed linear correlation between synapse size and AMPAR number indicating a common intra-synapse-type relationship in CNS synapses. On the contrary, inter-synapse-type relationship is unexpected indicating no correlation between averages of synapse size and AMPAR number. Interestingly, connections with large average synapse size and low AMPAR density showed high variability of AMPAR number and mosaic distribution within the postsynaptic membrane. We propose an idea that these connections may quickly exhibit synaptic plasticity by modifying AMPAR density/number whereas those with high AMPAR density change their efficacy by modifying synapse size."}],"quality_controlled":0,"extern":1,"date_published":"2012-06-01T00:00:00Z","author":[{"full_name":"Fukazawa, Yugo","last_name":"Fukazawa","first_name":"Yugo"},{"full_name":"Ryuichi Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","orcid":"0000-0001-8761-9444","last_name":"Shigemoto"}],"doi":"10.1016/j.conb.2012.01.006","date_updated":"2021-01-12T06:59:03Z"},{"date_updated":"2021-01-12T06:59:04Z","doi":"10.1523/JNEUROSCI.1142-12.2012","date_published":"2012-09-26T00:00:00Z","author":[{"last_name":"Parajuli","first_name":"Laxmi","full_name":"Parajuli, Laxmi K"},{"full_name":"Nakajima, Chikako","first_name":"Chikako","last_name":"Nakajima"},{"last_name":"Kulik","first_name":"Ákos","full_name":"Kulik, Ákos"},{"full_name":"Matsui, Ko","first_name":"Ko","last_name":"Matsui"},{"full_name":"Schneider, Toni","first_name":"Toni","last_name":"Schneider"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Ryuichi Shigemoto","last_name":"Shigemoto","orcid":"0000-0001-8761-9444","first_name":"Ryuichi"},{"first_name":"Yugo","last_name":"Fukazawa","full_name":"Fukazawa, Yugo"}],"extern":1,"quality_controlled":0,"abstract":[{"lang":"eng","text":"R-type calcium channels (RTCCs) are well known for their role in synaptic plasticity, but little is known about their subcellular distribution across various neuronal compartments. Using subtype-specific antibodies, we characterized the regional and subcellular localization of Ca v2.3 in mice and rats at both light and electron microscopic levels. Ca v2.3 immunogold particles were found to be predominantly presynaptic in the interpeduncular nucleus, but postsynaptic in other brain regions. Serial section analysis of electron microscopic images from the hippocampal CA1 revealed a higher density of immunogold particles in the dendritic shaft plasma membrane compared with the pyramidal cell somata. However, the labeling densities were not significantly different among the apical, oblique, or basal dendrites. Immunogold particles were also observed over the plasma membrane of dendritic spines, including both synaptic and extrasynaptic sites. Individual spine heads contained &lt;20 immunogold particles, with an average density of ~260 immunoparticles per μm 3 spine head volume, in accordance with the density of RTCCs estimated using calcium imaging (Sabatini and Svoboda, 2000). The Ca v2.3 density was variable among similar-sized spine heads and did not correlate with the density in the parent dendrite, implying that spines are individual calcium compartments operating autonomously from their parent dendrites."}],"publisher":"Society for Neuroscience","publication":"Journal of Neuroscience","title":"Quantitative regional and ultra structural localization of the Ca v2 3 subunit of R type calcium channel in mouse brain","publist_id":"4208","date_created":"2018-12-11T11:59:05Z","issue":"39","day":"26","status":"public","month":"09","citation":{"ieee":"L. Parajuli <i>et al.</i>, “Quantitative regional and ultra structural localization of the Ca v2 3 subunit of R type calcium channel in mouse brain,” <i>Journal of Neuroscience</i>, vol. 32, no. 39. Society for Neuroscience, pp. 13555–13567, 2012.","chicago":"Parajuli, Laxmi, Chikako Nakajima, Ákos Kulik, Ko Matsui, Toni Schneider, Ryuichi Shigemoto, and Yugo Fukazawa. “Quantitative Regional and Ultra Structural Localization of the Ca v2 3 Subunit of R Type Calcium Channel in Mouse Brain.” <i>Journal of Neuroscience</i>. Society for Neuroscience, 2012. <a href=\"https://doi.org/10.1523/JNEUROSCI.1142-12.2012\">https://doi.org/10.1523/JNEUROSCI.1142-12.2012</a>.","apa":"Parajuli, L., Nakajima, C., Kulik, Á., Matsui, K., Schneider, T., Shigemoto, R., &#38; Fukazawa, Y. (2012). Quantitative regional and ultra structural localization of the Ca v2 3 subunit of R type calcium channel in mouse brain. <i>Journal of Neuroscience</i>. Society for Neuroscience. <a href=\"https://doi.org/10.1523/JNEUROSCI.1142-12.2012\">https://doi.org/10.1523/JNEUROSCI.1142-12.2012</a>","ama":"Parajuli L, Nakajima C, Kulik Á, et al. Quantitative regional and ultra structural localization of the Ca v2 3 subunit of R type calcium channel in mouse brain. <i>Journal of Neuroscience</i>. 2012;32(39):13555-13567. doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.1142-12.2012\">10.1523/JNEUROSCI.1142-12.2012</a>","mla":"Parajuli, Laxmi, et al. “Quantitative Regional and Ultra Structural Localization of the Ca v2 3 Subunit of R Type Calcium Channel in Mouse Brain.” <i>Journal of Neuroscience</i>, vol. 32, no. 39, Society for Neuroscience, 2012, pp. 13555–67, doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.1142-12.2012\">10.1523/JNEUROSCI.1142-12.2012</a>.","ista":"Parajuli L, Nakajima C, Kulik Á, Matsui K, Schneider T, Shigemoto R, Fukazawa Y. 2012. Quantitative regional and ultra structural localization of the Ca v2 3 subunit of R type calcium channel in mouse brain. Journal of Neuroscience. 32(39), 13555–13567.","short":"L. Parajuli, C. Nakajima, Á. Kulik, K. Matsui, T. Schneider, R. Shigemoto, Y. Fukazawa, Journal of Neuroscience 32 (2012) 13555–13567."},"type":"journal_article","volume":32,"page":"13555 - 13567","year":"2012","publication_status":"published","_id":"2689","intvolume":"        32"},{"_id":"2696","main_file_link":[{"url":"http://arxiv.org/abs/1212.0839","open_access":"1"}],"publication_status":"published","year":"2012","type":"preprint","citation":{"chicago":"Erdös, László. “Universality for Random Matrices and Log-Gases.” <i>ArXiv</i>. ArXiv, 2012.","ieee":"L. Erdös, “Universality for random matrices and log-gases,” <i>ArXiv</i>. ArXiv, 2012.","apa":"Erdös, L. (2012). Universality for random matrices and log-gases. <i>ArXiv</i>. ArXiv.","ama":"Erdös L. Universality for random matrices and log-gases. <i>ArXiv</i>. 2012.","short":"L. Erdös, ArXiv (2012).","mla":"Erdös, László. “Universality for Random Matrices and Log-Gases.” <i>ArXiv</i>, ArXiv, 2012.","ista":"Erdös L. 2012. Universality for random matrices and log-gases. ArXiv, ."},"month":"12","status":"public","oa":1,"day":"04","date_created":"2018-12-11T11:59:07Z","publist_id":"4201","title":"Universality for random matrices and log-gases","publication":"ArXiv","publisher":"ArXiv","quality_controlled":0,"extern":1,"date_published":"2012-12-04T00:00:00Z","author":[{"id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","full_name":"László Erdös","last_name":"Erdös","orcid":"0000-0001-5366-9603","first_name":"László"}],"date_updated":"2021-01-12T06:59:06Z"},{"status":"public","oa":1,"day":"24","citation":{"apa":"Erdös, L. (2012). Lecture notes on quantum Brownian motion (Vol. 95, pp. 3–98). Presented at the Les Houches Summer School 2010, Oxford University Press.","ieee":"L. Erdös, “Lecture notes on quantum Brownian motion,” presented at the Les Houches Summer School 2010, 2012, vol. 95, pp. 3–98.","chicago":"Erdös, László. “Lecture Notes on Quantum Brownian Motion,” 95:3–98. Oxford University Press, 2012.","ista":"Erdös L. 2012. Lecture notes on quantum Brownian motion. Les Houches Summer School 2010, Quantum Theory from Small to Large Scales, vol. 95, 3–98.","mla":"Erdös, László. <i>Lecture Notes on Quantum Brownian Motion</i>. Vol. 95, Oxford University Press, 2012, pp. 3–98.","short":"L. Erdös, in:, Oxford University Press, 2012, pp. 3–98.","ama":"Erdös L. Lecture notes on quantum Brownian motion. In: Vol 95. Oxford University Press; 2012:3-98."},"month":"05","volume":95,"page":"3 - 98","type":"conference","main_file_link":[{"url":"http://arxiv.org/abs/1009.0843","open_access":"1"}],"_id":"2700","intvolume":"        95","year":"2012","publication_status":"published","date_published":"2012-05-24T00:00:00Z","author":[{"last_name":"Erdös","orcid":"0000-0001-5366-9603","first_name":"László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","full_name":"László Erdös"}],"alternative_title":["Quantum Theory from Small to Large Scales"],"date_updated":"2021-01-12T06:59:08Z","quality_controlled":0,"extern":1,"title":"Lecture notes on quantum Brownian motion","publisher":"Oxford University Press","date_created":"2018-12-11T11:59:08Z","conference":{"name":"Les Houches Summer School 2010"},"publist_id":"4196"},{"quality_controlled":"1","scopus_import":1,"date_updated":"2023-02-23T10:06:04Z","doi":"10.4230/LIPIcs.FSTTCS.2012.461","related_material":{"record":[{"id":"1598","status":"public","relation":"later_version"}]},"alternative_title":["LIPIcs"],"pubrep_id":"525","author":[{"last_name":"Chatterjee","orcid":"0000-0002-4561-241X","first_name":"Krishnendu","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","full_name":"Chatterjee, Krishnendu"},{"full_name":"Joglekar, Manas","last_name":"Joglekar","first_name":"Manas"},{"last_name":"Shah","first_name":"Nisarg","full_name":"Shah, Nisarg"}],"date_published":"2012-12-10T00:00:00Z","conference":{"name":"FSTTCS: Foundations of Software Technology and Theoretical Computer Science","end_date":"2012-12-17","location":"Hyderabad, India","start_date":"2012-12-15"},"tmp":{"short":"CC BY-NC-ND (4.0)","image":"/images/cc_by_nc_nd.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)"},"file_date_updated":"2020-07-14T12:45:45Z","month":"12","project":[{"call_identifier":"FWF","grant_number":"P 23499-N23","name":"Modern Graph Algorithmic Techniques in Formal Verification","_id":"2584A770-B435-11E9-9278-68D0E5697425"},{"call_identifier":"FWF","_id":"25863FF4-B435-11E9-9278-68D0E5697425","name":"Game Theory","grant_number":"S11407"},{"name":"Quantitative Graph Games: Theory and Applications","grant_number":"279307","_id":"2581B60A-B435-11E9-9278-68D0E5697425","call_identifier":"FP7"},{"_id":"2587B514-B435-11E9-9278-68D0E5697425","name":"Microsoft Research Faculty Fellowship"}],"language":[{"iso":"eng"}],"ddc":["000"],"day":"10","file":[{"date_updated":"2020-07-14T12:45:45Z","file_id":"5040","checksum":"d4d644ed1a885dbfc4fa1ef4c5724dab","file_name":"IST-2016-525-v1+1_42_1_.pdf","file_size":519040,"access_level":"open_access","creator":"system","relation":"main_file","date_created":"2018-12-12T10:13:53Z","content_type":"application/pdf"}],"publication_status":"published","intvolume":"        18","abstract":[{"text":"We consider Markov decision processes (MDPs) with specifications given as Büchi (liveness) objectives. We consider the problem of computing the set of almost-sure winning vertices from where the objective can be ensured with probability 1. We study for the first time the average case complexity of the classical algorithm for computing the set of almost-sure winning vertices for MDPs with Büchi objectives. Our contributions are as follows: First, we show that for MDPs with constant out-degree the expected number of iterations is at most logarithmic and the average case running time is linear (as compared to the worst case linear number of iterations and quadratic time complexity). Second, for the average case analysis over all MDPs we show that the expected number of iterations is constant and the average case running time is linear (again as compared to the worst case linear number of iterations and quadratic time complexity). Finally we also show that given that all MDPs are equally likely, the probability that the classical algorithm requires more than constant number of iterations is exponentially small.","lang":"eng"}],"publist_id":"4180","date_created":"2018-12-11T11:59:13Z","ec_funded":1,"oa_version":"Published Version","publisher":"Schloss Dagstuhl - Leibniz-Zentrum für Informatik","title":"Average case analysis of the classical algorithm for Markov decision processes with Büchi objectives","department":[{"_id":"KrCh"}],"citation":{"ieee":"K. Chatterjee, M. Joglekar, and N. Shah, “Average case analysis of the classical algorithm for Markov decision processes with Büchi objectives,” presented at the FSTTCS: Foundations of Software Technology and Theoretical Computer Science, Hyderabad, India, 2012, vol. 18, pp. 461–473.","chicago":"Chatterjee, Krishnendu, Manas Joglekar, and Nisarg Shah. “Average Case Analysis of the Classical Algorithm for Markov Decision Processes with Büchi Objectives,” 18:461–73. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2012. <a href=\"https://doi.org/10.4230/LIPIcs.FSTTCS.2012.461\">https://doi.org/10.4230/LIPIcs.FSTTCS.2012.461</a>.","apa":"Chatterjee, K., Joglekar, M., &#38; Shah, N. (2012). Average case analysis of the classical algorithm for Markov decision processes with Büchi objectives (Vol. 18, pp. 461–473). Presented at the FSTTCS: Foundations of Software Technology and Theoretical Computer Science, Hyderabad, India: Schloss Dagstuhl - Leibniz-Zentrum für Informatik. <a href=\"https://doi.org/10.4230/LIPIcs.FSTTCS.2012.461\">https://doi.org/10.4230/LIPIcs.FSTTCS.2012.461</a>","ama":"Chatterjee K, Joglekar M, Shah N. Average case analysis of the classical algorithm for Markov decision processes with Büchi objectives. In: Vol 18. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2012:461-473. doi:<a href=\"https://doi.org/10.4230/LIPIcs.FSTTCS.2012.461\">10.4230/LIPIcs.FSTTCS.2012.461</a>","ista":"Chatterjee K, Joglekar M, Shah N. 2012. Average case analysis of the classical algorithm for Markov decision processes with Büchi objectives. FSTTCS: Foundations of Software Technology and Theoretical Computer Science, LIPIcs, vol. 18, 461–473.","short":"K. Chatterjee, M. Joglekar, N. Shah, in:, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2012, pp. 461–473.","mla":"Chatterjee, Krishnendu, et al. <i>Average Case Analysis of the Classical Algorithm for Markov Decision Processes with Büchi Objectives</i>. Vol. 18, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2012, pp. 461–73, doi:<a href=\"https://doi.org/10.4230/LIPIcs.FSTTCS.2012.461\">10.4230/LIPIcs.FSTTCS.2012.461</a>."},"oa":1,"status":"public","has_accepted_license":"1","year":"2012","_id":"2715","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","type":"conference","volume":18,"page":"461 - 473"},{"intvolume":"       154","_id":"2767","year":"2012","publication_status":"published","volume":154,"page":"341 - 407","type":"journal_article","citation":{"apa":"Erdös, L., Yau, H., &#38; Yin, J. (2012). Bulk universality for generalized Wigner matrices. <i>Probability Theory and Related Fields</i>. Springer. <a href=\"https://doi.org/10.1007/s00440-011-0390-3\">https://doi.org/10.1007/s00440-011-0390-3</a>","chicago":"Erdös, László, Horng Yau, and Jun Yin. “Bulk Universality for Generalized Wigner Matrices.” <i>Probability Theory and Related Fields</i>. Springer, 2012. <a href=\"https://doi.org/10.1007/s00440-011-0390-3\">https://doi.org/10.1007/s00440-011-0390-3</a>.","ieee":"L. Erdös, H. Yau, and J. Yin, “Bulk universality for generalized Wigner matrices,” <i>Probability Theory and Related Fields</i>, vol. 154, no. 1–2. Springer, pp. 341–407, 2012.","mla":"Erdös, László, et al. “Bulk Universality for Generalized Wigner Matrices.” <i>Probability Theory and Related Fields</i>, vol. 154, no. 1–2, Springer, 2012, pp. 341–407, doi:<a href=\"https://doi.org/10.1007/s00440-011-0390-3\">10.1007/s00440-011-0390-3</a>.","short":"L. Erdös, H. Yau, J. Yin, Probability Theory and Related Fields 154 (2012) 341–407.","ista":"Erdös L, Yau H, Yin J. 2012. Bulk universality for generalized Wigner matrices. Probability Theory and Related Fields. 154(1–2), 341–407.","ama":"Erdös L, Yau H, Yin J. Bulk universality for generalized Wigner matrices. <i>Probability Theory and Related Fields</i>. 2012;154(1-2):341-407. doi:<a href=\"https://doi.org/10.1007/s00440-011-0390-3\">10.1007/s00440-011-0390-3</a>"},"month":"10","status":"public","issue":"1-2","day":"01","date_created":"2018-12-11T11:59:29Z","publist_id":"4123","publication":"Probability Theory and Related Fields","title":"Bulk universality for generalized Wigner matrices","publisher":"Springer","abstract":[{"text":"Consider N × N Hermitian or symmetric random matrices H where the distribution of the (i, j) matrix element is given by a probability measure ν ij with a subexponential decay. Let σ ij 2 be the variance for the probability measure ν ij with the normalization property that Σ iσ i,j 2 = 1 for all j. Under essentially the only condition that c ≤ N σ ij 2 ≤ c -1 for some constant c &gt; 0, we prove that, in the limit N → ∞, the eigenvalue spacing statistics of H in the bulk of the spectrum coincide with those of the Gaussian unitary or orthogonal ensemble (GUE or GOE). We also show that for band matrices with bandwidth M the local semicircle law holds to the energy scale M -1. ","lang":"eng"}],"extern":1,"quality_controlled":0,"date_published":"2012-10-01T00:00:00Z","author":[{"full_name":"László Erdös","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","first_name":"László","orcid":"0000-0001-5366-9603","last_name":"Erdös"},{"last_name":"Yau","first_name":"Horng","full_name":"Yau, Horng-Tzer"},{"first_name":"Jun","last_name":"Yin","full_name":"Yin, Jun"}],"doi":"10.1007/s00440-011-0390-3","date_updated":"2021-01-12T06:59:33Z"},{"publication_status":"published","year":"2012","_id":"2768","intvolume":"       309","type":"journal_article","page":"507 - 542","volume":309,"month":"01","citation":{"apa":"Erdös, L., &#38; Hasler, D. (2012). Wegner estimate and Anderson localization for random magnetic fields. <i>Communications in Mathematical Physics</i>. Springer. <a href=\"https://doi.org/10.1007/s00220-011-1373-z\">https://doi.org/10.1007/s00220-011-1373-z</a>","chicago":"Erdös, László, and David Hasler. “Wegner Estimate and Anderson Localization for Random Magnetic Fields.” <i>Communications in Mathematical Physics</i>. Springer, 2012. <a href=\"https://doi.org/10.1007/s00220-011-1373-z\">https://doi.org/10.1007/s00220-011-1373-z</a>.","ieee":"L. Erdös and D. Hasler, “Wegner estimate and Anderson localization for random magnetic fields,” <i>Communications in Mathematical Physics</i>, vol. 309, no. 2. Springer, pp. 507–542, 2012.","ista":"Erdös L, Hasler D. 2012. Wegner estimate and Anderson localization for random magnetic fields. Communications in Mathematical Physics. 309(2), 507–542.","short":"L. Erdös, D. Hasler, Communications in Mathematical Physics 309 (2012) 507–542.","mla":"Erdös, László, and David Hasler. “Wegner Estimate and Anderson Localization for Random Magnetic Fields.” <i>Communications in Mathematical Physics</i>, vol. 309, no. 2, Springer, 2012, pp. 507–42, doi:<a href=\"https://doi.org/10.1007/s00220-011-1373-z\">10.1007/s00220-011-1373-z</a>.","ama":"Erdös L, Hasler D. Wegner estimate and Anderson localization for random magnetic fields. <i>Communications in Mathematical Physics</i>. 2012;309(2):507-542. doi:<a href=\"https://doi.org/10.1007/s00220-011-1373-z\">10.1007/s00220-011-1373-z</a>"},"day":"01","issue":"2","status":"public","publist_id":"4122","date_created":"2018-12-11T11:59:30Z","publisher":"Springer","title":"Wegner estimate and Anderson localization for random magnetic fields","publication":"Communications in Mathematical Physics","quality_controlled":0,"extern":1,"abstract":[{"lang":"eng","text":"We consider a two dimensional magnetic Schrödinger operator with a spatially stationary random magnetic field. We assume that the magnetic field has a positive lower bound and that it has Fourier modes on arbitrarily short scales. We prove the Wegner estimate at arbitrary energy, i. e. we show that the averaged density of states is finite throughout the whole spectrum. We also prove Anderson localization at the bottom of the spectrum."}],"doi":"10.1007/s00220-011-1373-z","date_updated":"2021-01-12T06:59:34Z","date_published":"2012-01-01T00:00:00Z","author":[{"full_name":"László Erdös","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","first_name":"László","last_name":"Erdös","orcid":"0000-0001-5366-9603"},{"first_name":"David","last_name":"Hasler","full_name":"Hasler, David G"}]},{"publication_status":"published","year":"2012","intvolume":"        48","_id":"2769","type":"journal_article","page":"1 - 46","volume":48,"month":"02","citation":{"short":"L. Erdös, B. Schlein, H. Yau, J. Yin, Annales de l’institut Henri Poincare (B) Probability and Statistics 48 (2012) 1–46.","ista":"Erdös L, Schlein B, Yau H, Yin J. 2012. The local relaxation flow approach to universality of the local statistics for random matrices. Annales de l’institut Henri Poincare (B) Probability and Statistics. 48(1), 1–46.","mla":"Erdös, László, et al. “The Local Relaxation Flow Approach to Universality of the Local Statistics for Random Matrices.” <i>Annales de l’institut Henri Poincare (B) Probability and Statistics</i>, vol. 48, no. 1, Institute of Mathematical Statistics, 2012, pp. 1–46, doi:<a href=\"https://doi.org/10.1214/10-AIHP388\">10.1214/10-AIHP388</a>.","ama":"Erdös L, Schlein B, Yau H, Yin J. The local relaxation flow approach to universality of the local statistics for random matrices. <i>Annales de l’institut Henri Poincare (B) Probability and Statistics</i>. 2012;48(1):1-46. doi:<a href=\"https://doi.org/10.1214/10-AIHP388\">10.1214/10-AIHP388</a>","apa":"Erdös, L., Schlein, B., Yau, H., &#38; Yin, J. (2012). The local relaxation flow approach to universality of the local statistics for random matrices. <i>Annales de l’institut Henri Poincare (B) Probability and Statistics</i>. Institute of Mathematical Statistics. <a href=\"https://doi.org/10.1214/10-AIHP388\">https://doi.org/10.1214/10-AIHP388</a>","ieee":"L. Erdös, B. Schlein, H. Yau, and J. Yin, “The local relaxation flow approach to universality of the local statistics for random matrices,” <i>Annales de l’institut Henri Poincare (B) Probability and Statistics</i>, vol. 48, no. 1. Institute of Mathematical Statistics, pp. 1–46, 2012.","chicago":"Erdös, László, Benjamin Schlein, Horng Yau, and Jun Yin. “The Local Relaxation Flow Approach to Universality of the Local Statistics for Random Matrices.” <i>Annales de l’institut Henri Poincare (B) Probability and Statistics</i>. Institute of Mathematical Statistics, 2012. <a href=\"https://doi.org/10.1214/10-AIHP388\">https://doi.org/10.1214/10-AIHP388</a>."},"day":"01","issue":"1","status":"public","publist_id":"4121","date_created":"2018-12-11T11:59:30Z","publisher":"Institute of Mathematical Statistics","title":"The local relaxation flow approach to universality of the local statistics for random matrices","publication":"Annales de l'institut Henri Poincare (B) Probability and Statistics","extern":1,"quality_controlled":0,"abstract":[{"text":"We present a generalization of the method of the local relaxation flow to establish the universality of local spectral statistics of a broad class of large random matrices. We show that the local distribution of the eigenvalues coincides with the local statistics of the corresponding Gaussian ensemble provided the distribution of the individual matrix element is smooth and the eigenvalues {X J} N j=1 are close to their classical location {y j} N j=1 determined by the limiting density of eigenvalues. Under the scaling where the typical distance between neighboring eigenvalues is of order 1/N, the necessary apriori estimate on the location of eigenvalues requires only to know that E|x j - γ j| 2 ≤ N-1-ε on average. This information can be obtained by well established methods for various matrix ensembles. We demonstrate the method by proving local spectral universality for sample covariance matrices.","lang":"eng"}],"doi":"10.1214/10-AIHP388","date_updated":"2021-01-12T06:59:34Z","author":[{"last_name":"Erdös","orcid":"0000-0001-5366-9603","first_name":"László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","full_name":"László Erdös"},{"full_name":"Schlein, Benjamin","first_name":"Benjamin","last_name":"Schlein"},{"full_name":"Yau, Horng-Tzer","last_name":"Yau","first_name":"Horng"},{"full_name":"Yin, Jun","first_name":"Jun","last_name":"Yin"}],"date_published":"2012-02-01T00:00:00Z"},{"citation":{"apa":"Erdös, L., Yau, H., &#38; Yin, J. (2012). Rigidity of eigenvalues of generalized Wigner matrices. <i>Advances in Mathematics</i>. Academic Press. <a href=\"https://doi.org/10.1016/j.aim.2011.12.010\">https://doi.org/10.1016/j.aim.2011.12.010</a>","chicago":"Erdös, László, Horng Yau, and Jun Yin. “Rigidity of Eigenvalues of Generalized Wigner Matrices.” <i>Advances in Mathematics</i>. Academic Press, 2012. <a href=\"https://doi.org/10.1016/j.aim.2011.12.010\">https://doi.org/10.1016/j.aim.2011.12.010</a>.","ieee":"L. Erdös, H. Yau, and J. Yin, “Rigidity of eigenvalues of generalized Wigner matrices,” <i>Advances in Mathematics</i>, vol. 229, no. 3. Academic Press, pp. 1435–1515, 2012.","ista":"Erdös L, Yau H, Yin J. 2012. Rigidity of eigenvalues of generalized Wigner matrices. Advances in Mathematics. 229(3), 1435–1515.","short":"L. Erdös, H. Yau, J. Yin, Advances in Mathematics 229 (2012) 1435–1515.","mla":"Erdös, László, et al. “Rigidity of Eigenvalues of Generalized Wigner Matrices.” <i>Advances in Mathematics</i>, vol. 229, no. 3, Academic Press, 2012, pp. 1435–515, doi:<a href=\"https://doi.org/10.1016/j.aim.2011.12.010\">10.1016/j.aim.2011.12.010</a>.","ama":"Erdös L, Yau H, Yin J. Rigidity of eigenvalues of generalized Wigner matrices. <i>Advances in Mathematics</i>. 2012;229(3):1435-1515. doi:<a href=\"https://doi.org/10.1016/j.aim.2011.12.010\">10.1016/j.aim.2011.12.010</a>"},"month":"02","status":"public","day":"15","issue":"3","intvolume":"       229","_id":"2770","publication_status":"published","year":"2012","page":"1435 - 1515","volume":229,"type":"journal_article","abstract":[{"lang":"eng","text":"Consider N×N Hermitian or symmetric random matrices H with independent entries, where the distribution of the (i,j) matrix element is given by the probability measure vij with zero expectation and with variance σ ιj 2. We assume that the variances satisfy the normalization condition Σiσij2=1 for all j and that there is a positive constant c such that c≤Nσ ιj 2 ιc -1. We further assume that the probability distributions νij have a uniform subexponential decay. We prove that the Stieltjes transform of the empirical eigenvalue distribution of H is given by the Wigner semicircle law uniformly up to the edges of the spectrum with an error of order (Nη) -1 where η is the imaginary part of the spectral parameter in the Stieltjes transform. There are three corollaries to this strong local semicircle law: (1) Rigidity of eigenvalues: If γj=γj,N denotes the classical location of the j-th eigenvalue under the semicircle law ordered in increasing order, then the j-th eigenvalue λj is close to γj in the sense that for some positive constants C, c P{double-struck}(∃j:|λ j-γ j|≥(logN) CloglogN[min(j,N-j+1)] -1/3N -2/3)≤ C exp[-(logN) cloglogN] for N large enough. (2) The proof of Dyson's conjecture (Dyson, 1962 [15]) which states that the time scale of the Dyson Brownian motion to reach local equilibrium is of order N -1 up to logarithmic corrections. (3) The edge universality holds in the sense that the probability distributions of the largest (and the smallest) eigenvalues of two generalized Wigner ensembles are the same in the large N limit provided that the second moments of the two ensembles are identical."}],"quality_controlled":0,"extern":1,"author":[{"id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","full_name":"László Erdös","orcid":"0000-0001-5366-9603","last_name":"Erdös","first_name":"László"},{"full_name":"Yau, Horng-Tzer","first_name":"Horng","last_name":"Yau"},{"last_name":"Yin","first_name":"Jun","full_name":"Yin, Jun"}],"date_published":"2012-02-15T00:00:00Z","doi":"10.1016/j.aim.2011.12.010","date_updated":"2021-01-12T06:59:35Z","date_created":"2018-12-11T11:59:30Z","publist_id":"4120","title":"Rigidity of eigenvalues of generalized Wigner matrices","publication":"Advances in Mathematics","publisher":"Academic Press"},{"extern":1,"quality_controlled":0,"abstract":[{"lang":"eng","text":"We consider a magnetic Schrödinger operator in two dimensions. The magnetic field is given as the sum of a large and constant magnetic field and a random magnetic field. Moreover, we allow for an additional deterministic potential as well as a magnetic field which are both periodic. We show that the spectrum of this operator is contained in broadened bands around the Landau levels and that the edges of these bands consist of pure point spectrum with exponentially decaying eigenfunctions. The proof is based on a recent Wegner estimate obtained in Erdos and Hasler (Commun. Math. Phys., preprint, arXiv:1012.5185) and a multiscale analysis."}],"doi":"10.1007/s10955-012-0445-6","date_updated":"2021-01-12T06:59:35Z","author":[{"first_name":"László","orcid":"0000-0001-5366-9603","last_name":"Erdös","full_name":"László Erdös","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Hasler","first_name":"David","full_name":"Hasler, David G"}],"date_published":"2012-03-01T00:00:00Z","publist_id":"4119","date_created":"2018-12-11T11:59:31Z","publisher":"Springer","title":"Anderson localization at band edges for random magnetic fields","publication":"Journal of Statistical Physics","month":"03","citation":{"apa":"Erdös, L., &#38; Hasler, D. (2012). Anderson localization at band edges for random magnetic fields. <i>Journal of Statistical Physics</i>. Springer. <a href=\"https://doi.org/10.1007/s10955-012-0445-6\">https://doi.org/10.1007/s10955-012-0445-6</a>","ieee":"L. Erdös and D. Hasler, “Anderson localization at band edges for random magnetic fields,” <i>Journal of Statistical Physics</i>, vol. 146, no. 5. Springer, pp. 900–923, 2012.","chicago":"Erdös, László, and David Hasler. “Anderson Localization at Band Edges for Random Magnetic Fields.” <i>Journal of Statistical Physics</i>. Springer, 2012. <a href=\"https://doi.org/10.1007/s10955-012-0445-6\">https://doi.org/10.1007/s10955-012-0445-6</a>.","ista":"Erdös L, Hasler D. 2012. Anderson localization at band edges for random magnetic fields. Journal of Statistical Physics. 146(5), 900–923.","mla":"Erdös, László, and David Hasler. “Anderson Localization at Band Edges for Random Magnetic Fields.” <i>Journal of Statistical Physics</i>, vol. 146, no. 5, Springer, 2012, pp. 900–23, doi:<a href=\"https://doi.org/10.1007/s10955-012-0445-6\">10.1007/s10955-012-0445-6</a>.","short":"L. Erdös, D. Hasler, Journal of Statistical Physics 146 (2012) 900–923.","ama":"Erdös L, Hasler D. Anderson localization at band edges for random magnetic fields. <i>Journal of Statistical Physics</i>. 2012;146(5):900-923. doi:<a href=\"https://doi.org/10.1007/s10955-012-0445-6\">10.1007/s10955-012-0445-6</a>"},"day":"01","issue":"5","status":"public","publication_status":"published","year":"2012","_id":"2771","intvolume":"       146","type":"journal_article","page":"900 - 923","volume":146},{"title":"Second order semiclassics with self generated magnetic fields","publication":"Annales Henri Poincare","publisher":"Birkhäuser","date_created":"2018-12-11T11:59:31Z","publist_id":"4118","date_published":"2012-05-01T00:00:00Z","author":[{"orcid":"0000-0001-5366-9603","last_name":"Erdös","first_name":"László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","full_name":"László Erdös"},{"full_name":"Fournais, Søren","first_name":"Søren","last_name":"Fournais"},{"last_name":"Solovej","first_name":"Jan","full_name":"Solovej, Jan P"}],"date_updated":"2021-01-12T06:59:36Z","doi":"10.1007/s00023-011-0150-z","abstract":[{"text":"We consider the semiclassical asymptotics of the sum of negative eigenvalues of the three-dimensional Pauli operator with an external potential and a self-generated magnetic field B. We also add the field energy β ∫ B 2 and we minimize over all magnetic fields. The parameter β effectively determines the strength of the field. We consider the weak field regime with βh 2 ≥ const &gt; 0, where h is the semiclassical parameter. For smooth potentials we prove that the semiclassical asymptotics of the total energy is given by the non-magnetic Weyl term to leading order with an error bound that is smaller by a factor h 1+e{open}, i. e. the subleading term vanishes. However for potentials with a Coulomb singularity, the subleading term does not vanish due to the non-semiclassical effect of the singularity. Combined with a multiscale technique, this refined estimate is used in the companion paper (Erdo{double acute}s et al. in Scott correction for large molecules with a self-generated magnetic field, Preprint, 2011) to prove the second order Scott correction to the ground state energy of large atoms and molecules.","lang":"eng"}],"quality_controlled":0,"extern":1,"page":"671 - 730","volume":13,"type":"journal_article","_id":"2772","intvolume":"        13","publication_status":"published","year":"2012","status":"public","day":"01","issue":"4","citation":{"apa":"Erdös, L., Fournais, S., &#38; Solovej, J. (2012). Second order semiclassics with self generated magnetic fields. <i>Annales Henri Poincare</i>. Birkhäuser. <a href=\"https://doi.org/10.1007/s00023-011-0150-z\">https://doi.org/10.1007/s00023-011-0150-z</a>","ieee":"L. Erdös, S. Fournais, and J. Solovej, “Second order semiclassics with self generated magnetic fields,” <i>Annales Henri Poincare</i>, vol. 13, no. 4. Birkhäuser, pp. 671–730, 2012.","chicago":"Erdös, László, Søren Fournais, and Jan Solovej. “Second Order Semiclassics with Self Generated Magnetic Fields.” <i>Annales Henri Poincare</i>. Birkhäuser, 2012. <a href=\"https://doi.org/10.1007/s00023-011-0150-z\">https://doi.org/10.1007/s00023-011-0150-z</a>.","ista":"Erdös L, Fournais S, Solovej J. 2012. Second order semiclassics with self generated magnetic fields. Annales Henri Poincare. 13(4), 671–730.","mla":"Erdös, László, et al. “Second Order Semiclassics with Self Generated Magnetic Fields.” <i>Annales Henri Poincare</i>, vol. 13, no. 4, Birkhäuser, 2012, pp. 671–730, doi:<a href=\"https://doi.org/10.1007/s00023-011-0150-z\">10.1007/s00023-011-0150-z</a>.","short":"L. Erdös, S. Fournais, J. Solovej, Annales Henri Poincare 13 (2012) 671–730.","ama":"Erdös L, Fournais S, Solovej J. Second order semiclassics with self generated magnetic fields. <i>Annales Henri Poincare</i>. 2012;13(4):671-730. doi:<a href=\"https://doi.org/10.1007/s00023-011-0150-z\">10.1007/s00023-011-0150-z</a>"},"month":"05"}]