[{"author":[{"full_name":"Fuertbauer, Elke","last_name":"Fuertbauer","first_name":"Elke"},{"full_name":"Zaujec, Jan","last_name":"Zaujec","first_name":"Jan"},{"full_name":"Uhrin, Pavel","first_name":"Pavel","last_name":"Uhrin"},{"last_name":"Raab","first_name":"Ingrid","full_name":"Raab, Ingrid"},{"id":"3A3FC708-F248-11E8-B48F-1D18A9856A87","last_name":"Weber","first_name":"Michele","full_name":"Weber, Michele"},{"last_name":"Schachner","first_name":"Helga","full_name":"Schachner, Helga"},{"full_name":"Bauer, Miroslav","first_name":"Miroslav","last_name":"Bauer"},{"full_name":"Schütz, Gerhard","last_name":"Schütz","first_name":"Gerhard"},{"last_name":"Binder","first_name":"Bernd","full_name":"Binder, Bernd"},{"last_name":"Sixt","first_name":"Michael K","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","full_name":"Sixt, Michael K","orcid":"0000-0002-6620-9179"},{"full_name":"Kerjaschki, Dontscho","first_name":"Dontscho","last_name":"Kerjaschki"},{"last_name":"Stockinger","first_name":"Hannes","full_name":"Stockinger, Hannes"}],"oa_version":"None","month":"07","citation":{"chicago":"Fuertbauer, Elke, Jan Zaujec, Pavel Uhrin, Ingrid Raab, Michele Weber, Helga Schachner, Miroslav Bauer, et al. “Thymic Medullar Conduits-Associated Podoplanin Promotes Natural Regulatory T Cells.” <i>Immunology Letters</i>. Elsevier, 2013. <a href=\"https://doi.org/10.1016/j.imlet.2013.07.007\">https://doi.org/10.1016/j.imlet.2013.07.007</a>.","ieee":"E. Fuertbauer <i>et al.</i>, “Thymic medullar conduits-associated podoplanin promotes natural regulatory T cells,” <i>Immunology Letters</i>, vol. 154, no. 1–2. Elsevier, pp. 31–41, 2013.","mla":"Fuertbauer, Elke, et al. “Thymic Medullar Conduits-Associated Podoplanin Promotes Natural Regulatory T Cells.” <i>Immunology Letters</i>, vol. 154, no. 1–2, Elsevier, 2013, pp. 31–41, doi:<a href=\"https://doi.org/10.1016/j.imlet.2013.07.007\">10.1016/j.imlet.2013.07.007</a>.","short":"E. Fuertbauer, J. Zaujec, P. Uhrin, I. Raab, M. Weber, H. Schachner, M. Bauer, G. Schütz, B. Binder, M.K. Sixt, D. Kerjaschki, H. Stockinger, Immunology Letters 154 (2013) 31–41.","ama":"Fuertbauer E, Zaujec J, Uhrin P, et al. Thymic medullar conduits-associated podoplanin promotes natural regulatory T cells. <i>Immunology Letters</i>. 2013;154(1-2):31-41. doi:<a href=\"https://doi.org/10.1016/j.imlet.2013.07.007\">10.1016/j.imlet.2013.07.007</a>","ista":"Fuertbauer E, Zaujec J, Uhrin P, Raab I, Weber M, Schachner H, Bauer M, Schütz G, Binder B, Sixt MK, Kerjaschki D, Stockinger H. 2013. Thymic medullar conduits-associated podoplanin promotes natural regulatory T cells. Immunology Letters. 154(1–2), 31–41.","apa":"Fuertbauer, E., Zaujec, J., Uhrin, P., Raab, I., Weber, M., Schachner, H., … Stockinger, H. (2013). Thymic medullar conduits-associated podoplanin promotes natural regulatory T cells. <i>Immunology Letters</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.imlet.2013.07.007\">https://doi.org/10.1016/j.imlet.2013.07.007</a>"},"date_created":"2018-12-11T11:46:57Z","scopus_import":1,"issue":"1-2","publist_id":"7300","publication":"Immunology Letters","status":"public","date_published":"2013-07-01T00:00:00Z","page":"31 - 41","abstract":[{"text":"Podoplanin, a mucin-like plasma membrane protein, is expressed by lymphatic endothelial cells and responsible for separation of blood and lymphatic circulation through activation of platelets. Here we show that podoplanin is also expressed by thymic fibroblastic reticular cells (tFRC), a novel thymic medulla stroma cell type associated with thymic conduits, and involved in development of natural regulatory T cells (nTreg). Young mice deficient in podoplanin lack nTreg owing to retardation of CD4+CD25+ thymocytes in the cortex and missing differentiation of Foxp3+ thymocytes in the medulla. This might be due to CCL21 that delocalizes upon deletion of the CCL21-binding podoplanin from medullar tFRC to cortex areas. The animals do not remain devoid of nTreg but generate them delayed within the first month resulting in Th2-biased hypergammaglobulinemia but not in the death-causing autoimmune phenotype of Foxp3-deficient Scurfy mice.","lang":"eng"}],"intvolume":"       154","_id":"522","language":[{"iso":"eng"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","quality_controlled":"1","doi":"10.1016/j.imlet.2013.07.007","department":[{"_id":"MiSi"}],"title":"Thymic medullar conduits-associated podoplanin promotes natural regulatory T cells","date_updated":"2021-01-12T08:01:22Z","publisher":"Elsevier","day":"01","publication_status":"published","year":"2013","type":"journal_article","volume":154},{"ec_funded":1,"year":"2013","volume":23,"type":"journal_article","department":[{"_id":"EvBe"},{"_id":"JiFr"}],"title":"Modeling framework for the establishment of the apical-basal embryonic axis in plants","doi":"10.1016/j.cub.2013.10.038","project":[{"call_identifier":"FP7","grant_number":"282300","_id":"25716A02-B435-11E9-9278-68D0E5697425","name":"Polarity and subcellular dynamics in plants"}],"quality_controlled":"1","publication_status":"published","day":"16","publisher":"Cell Press","date_updated":"2021-01-12T08:01:24Z","abstract":[{"lang":"eng","text":"The apical-basal axis of the early plant embryo determines the body plan of the adult organism. To establish a polarized embryonic axis, plants evolved a unique mechanism that involves directional, cell-to-cell transport of the growth regulator auxin. Auxin transport relies on PIN auxin transporters [1], whose polar subcellular localization determines the flow directionality. PIN-mediated auxin transport mediates the spatial and temporal activity of the auxin response machinery [2-7] that contributes to embryo patterning processes, including establishment of the apical (shoot) and basal (root) embryo poles [8]. However, little is known of upstream mechanisms guiding the (re)polarization of auxin fluxes during embryogenesis [9]. Here, we developed a model of plant embryogenesis that correctly generates emergent cell polarities and auxin-mediated sequential initiation of apical-basal axis of plant embryo. The model relies on two precisely localized auxin sources and a feedback between auxin and the polar, subcellular PIN transporter localization. Simulations reproduced PIN polarity and auxin distribution, as well as previously unknown polarization events during early embryogenesis. The spectrum of validated model predictions suggests that our model corresponds to a minimal mechanistic framework for initiation and orientation of the apical-basal axis to guide both embryonic and postembryonic plant development."}],"page":"2513 - 2518","date_published":"2013-12-16T00:00:00Z","status":"public","issue":"24","publication":"Current Biology","publist_id":"7292","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"527","intvolume":"        23","language":[{"iso":"eng"}],"month":"12","author":[{"full_name":"Wabnik, Krzysztof T","orcid":"0000-0001-7263-0560","first_name":"Krzysztof T","last_name":"Wabnik","id":"4DE369A4-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Robert","first_name":"Hélène","full_name":"Robert, Hélène"},{"first_name":"Richard","last_name":"Smith","full_name":"Smith, Richard"},{"full_name":"Friml, Jirí","orcid":"0000-0002-8302-7596","first_name":"Jirí","last_name":"Friml","id":"4159519E-F248-11E8-B48F-1D18A9856A87"}],"oa_version":"None","scopus_import":1,"date_created":"2018-12-11T11:46:58Z","citation":{"short":"K.T. Wabnik, H. Robert, R. Smith, J. Friml, Current Biology 23 (2013) 2513–2518.","mla":"Wabnik, Krzysztof T., et al. “Modeling Framework for the Establishment of the Apical-Basal Embryonic Axis in Plants.” <i>Current Biology</i>, vol. 23, no. 24, Cell Press, 2013, pp. 2513–18, doi:<a href=\"https://doi.org/10.1016/j.cub.2013.10.038\">10.1016/j.cub.2013.10.038</a>.","chicago":"Wabnik, Krzysztof T, Hélène Robert, Richard Smith, and Jiří Friml. “Modeling Framework for the Establishment of the Apical-Basal Embryonic Axis in Plants.” <i>Current Biology</i>. Cell Press, 2013. <a href=\"https://doi.org/10.1016/j.cub.2013.10.038\">https://doi.org/10.1016/j.cub.2013.10.038</a>.","ieee":"K. T. Wabnik, H. Robert, R. Smith, and J. Friml, “Modeling framework for the establishment of the apical-basal embryonic axis in plants,” <i>Current Biology</i>, vol. 23, no. 24. Cell Press, pp. 2513–2518, 2013.","ista":"Wabnik KT, Robert H, Smith R, Friml J. 2013. Modeling framework for the establishment of the apical-basal embryonic axis in plants. Current Biology. 23(24), 2513–2518.","apa":"Wabnik, K. T., Robert, H., Smith, R., &#38; Friml, J. (2013). Modeling framework for the establishment of the apical-basal embryonic axis in plants. <i>Current Biology</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.cub.2013.10.038\">https://doi.org/10.1016/j.cub.2013.10.038</a>","ama":"Wabnik KT, Robert H, Smith R, Friml J. Modeling framework for the establishment of the apical-basal embryonic axis in plants. <i>Current Biology</i>. 2013;23(24):2513-2518. doi:<a href=\"https://doi.org/10.1016/j.cub.2013.10.038\">10.1016/j.cub.2013.10.038</a>"}},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","language":[{"iso":"eng"}],"_id":"528","intvolume":"        23","abstract":[{"lang":"eng","text":"Establishment of the embryonic axis foreshadows the main body axis of adults both in plants and in animals, but underlying mechanisms are considered distinct. Plants utilize directional, cell-to-cell transport of the growth hormone auxin [1, 2] to generate an asymmetric auxin response that specifies the embryonic apical-basal axis [3-6]. The auxin flow directionality depends on the polarized subcellular localization of PIN-FORMED (PIN) auxin transporters [7, 8]. It remains unknown which mechanisms and spatial cues guide cell polarization and axis orientation in early embryos. Herein, we provide conceptually novel insights into the formation of embryonic axis in Arabidopsis by identifying a crucial role of localized tryptophan-dependent auxin biosynthesis [9-12]. Local auxin production at the base of young embryos and the accompanying PIN7-mediated auxin flow toward the proembryo are required for the apical auxin response maximum and the specification of apical embryonic structures. Later in embryogenesis, the precisely timed onset of localized apical auxin biosynthesis mediates PIN1 polarization, basal auxin response maximum, and specification of the root pole. Thus, the tight spatiotemporal control of distinct local auxin sources provides a necessary, non-cell-autonomous trigger for the coordinated cell polarization and subsequent apical-basal axis orientation during embryogenesis and, presumably, also for other polarization events during postembryonic plant life [13, 14]."}],"page":"2506 - 2512","date_published":"2013-12-16T00:00:00Z","status":"public","publist_id":"7291","issue":"24","publication":"Current Biology","scopus_import":1,"citation":{"ama":"Robert H, Grones P, Stepanova A, et al. Local auxin sources orient the apical basal axis in arabidopsis embryos. <i>Current Biology</i>. 2013;23(24):2506-2512. doi:<a href=\"https://doi.org/10.1016/j.cub.2013.09.039\">10.1016/j.cub.2013.09.039</a>","ista":"Robert H, Grones P, Stepanova A, Robles L, Lokerse A, Alonso J, Weijers D, Friml J. 2013. Local auxin sources orient the apical basal axis in arabidopsis embryos. Current Biology. 23(24), 2506–2512.","apa":"Robert, H., Grones, P., Stepanova, A., Robles, L., Lokerse, A., Alonso, J., … Friml, J. (2013). Local auxin sources orient the apical basal axis in arabidopsis embryos. <i>Current Biology</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.cub.2013.09.039\">https://doi.org/10.1016/j.cub.2013.09.039</a>","chicago":"Robert, Hélène, Peter Grones, Anna Stepanova, Linda Robles, Annemarie Lokerse, Jose Alonso, Dolf Weijers, and Jiří Friml. “Local Auxin Sources Orient the Apical Basal Axis in Arabidopsis Embryos.” <i>Current Biology</i>. Cell Press, 2013. <a href=\"https://doi.org/10.1016/j.cub.2013.09.039\">https://doi.org/10.1016/j.cub.2013.09.039</a>.","ieee":"H. Robert <i>et al.</i>, “Local auxin sources orient the apical basal axis in arabidopsis embryos,” <i>Current Biology</i>, vol. 23, no. 24. Cell Press, pp. 2506–2512, 2013.","short":"H. Robert, P. Grones, A. Stepanova, L. Robles, A. Lokerse, J. Alonso, D. Weijers, J. Friml, Current Biology 23 (2013) 2506–2512.","mla":"Robert, Hélène, et al. “Local Auxin Sources Orient the Apical Basal Axis in Arabidopsis Embryos.” <i>Current Biology</i>, vol. 23, no. 24, Cell Press, 2013, pp. 2506–12, doi:<a href=\"https://doi.org/10.1016/j.cub.2013.09.039\">10.1016/j.cub.2013.09.039</a>."},"date_created":"2018-12-11T11:46:59Z","month":"12","oa_version":"None","author":[{"last_name":"Robert","first_name":"Hélène","full_name":"Robert, Hélène"},{"full_name":"Grones, Peter","id":"399876EC-F248-11E8-B48F-1D18A9856A87","last_name":"Grones","first_name":"Peter"},{"full_name":"Stepanova, Anna","last_name":"Stepanova","first_name":"Anna"},{"last_name":"Robles","first_name":"Linda","full_name":"Robles, Linda"},{"first_name":"Annemarie","last_name":"Lokerse","full_name":"Lokerse, Annemarie"},{"full_name":"Alonso, Jose","first_name":"Jose","last_name":"Alonso"},{"full_name":"Weijers, Dolf","last_name":"Weijers","first_name":"Dolf"},{"orcid":"0000-0002-8302-7596","full_name":"Friml, Jirí","last_name":"Friml","first_name":"Jirí","id":"4159519E-F248-11E8-B48F-1D18A9856A87"}],"volume":23,"type":"journal_article","ec_funded":1,"year":"2013","publication_status":"published","day":"16","publisher":"Cell Press","date_updated":"2021-01-12T08:01:25Z","department":[{"_id":"JiFr"}],"title":"Local auxin sources orient the apical basal axis in arabidopsis embryos","doi":"10.1016/j.cub.2013.09.039","project":[{"_id":"25716A02-B435-11E9-9278-68D0E5697425","name":"Polarity and subcellular dynamics in plants","grant_number":"282300","call_identifier":"FP7"}],"quality_controlled":"1"},{"volume":36,"type":"journal_article","publication_status":"published","publisher":"IEEE","department":[{"_id":"ChLa"}],"quality_controlled":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":"        36","abstract":[{"text":"We study the problem of object recognition for categories for which we have no training examples, a task also called zero-data or zero-shot learning. This situation has hardly been studied in computer vision research, even though it occurs frequently: the world contains tens of thousands of different object classes and for only few of them image collections have been formed and suitably annotated. To tackle the problem we introduce attribute-based classification: objects are identified based on a high-level description that is phrased in terms of semantic attributes, such as the object's color or shape. Because the identification of each such property transcends the specific learning task at hand, the attribute classifiers can be pre-learned independently, e.g. from existing image datasets unrelated to the current task. Afterwards, new classes can be detected based on their attribute representation, without the need for a new training phase. In this paper we also introduce a new dataset, Animals with Attributes, of over 30,000 images of 50 animal classes, annotated with 85 semantic attributes. Extensive experiments on this and two more datasets show that attribute-based classification indeed is able to categorize images without access to any training images of the target classes.","lang":"eng"}],"status":"public","date_published":"2013-07-30T00:00:00Z","publication":"IEEE Transactions on Pattern Analysis and Machine Intelligence","publist_id":"4385","scopus_import":"1","date_created":"2018-12-11T11:58:08Z","oa_version":"None","article_processing_charge":"No","year":"2013","day":"30","date_updated":"2026-06-18T07:51:30Z","title":"Attribute-based classification for zero-shot learning of object categories","doi":"10.1109/TPAMI.2013.140","_id":"2516","language":[{"iso":"eng"}],"page":"453 - 465","issue":"3","das_tickbox":"1","citation":{"chicago":"Lampert, Christoph, Hannes Nickisch, and Stefan Harmeling. “Attribute-Based Classification for Zero-Shot Learning of Object Categories.” <i>IEEE Transactions on Pattern Analysis and Machine Intelligence</i>. IEEE, 2013. <a href=\"https://doi.org/10.1109/TPAMI.2013.140\">https://doi.org/10.1109/TPAMI.2013.140</a>.","ieee":"C. Lampert, H. Nickisch, and S. Harmeling, “Attribute-based classification for zero-shot learning of object categories,” <i>IEEE Transactions on Pattern Analysis and Machine Intelligence</i>, vol. 36, no. 3. IEEE, pp. 453–465, 2013.","short":"C. Lampert, H. Nickisch, S. Harmeling, IEEE Transactions on Pattern Analysis and Machine Intelligence 36 (2013) 453–465.","mla":"Lampert, Christoph, et al. “Attribute-Based Classification for Zero-Shot Learning of Object Categories.” <i>IEEE Transactions on Pattern Analysis and Machine Intelligence</i>, vol. 36, no. 3, IEEE, 2013, pp. 453–65, doi:<a href=\"https://doi.org/10.1109/TPAMI.2013.140\">10.1109/TPAMI.2013.140</a>.","ama":"Lampert C, Nickisch H, Harmeling S. Attribute-based classification for zero-shot learning of object categories. <i>IEEE Transactions on Pattern Analysis and Machine Intelligence</i>. 2013;36(3):453-465. doi:<a href=\"https://doi.org/10.1109/TPAMI.2013.140\">10.1109/TPAMI.2013.140</a>","ista":"Lampert C, Nickisch H, Harmeling S. 2013. Attribute-based classification for zero-shot learning of object categories. IEEE Transactions on Pattern Analysis and Machine Intelligence. 36(3), 453–465.","apa":"Lampert, C., Nickisch, H., &#38; Harmeling, S. (2013). Attribute-based classification for zero-shot learning of object categories. <i>IEEE Transactions on Pattern Analysis and Machine Intelligence</i>. IEEE. <a href=\"https://doi.org/10.1109/TPAMI.2013.140\">https://doi.org/10.1109/TPAMI.2013.140</a>"},"ddc":["000"],"month":"07","author":[{"id":"40C20FD2-F248-11E8-B48F-1D18A9856A87","first_name":"Christoph","last_name":"Lampert","orcid":"0000-0001-8622-7887","full_name":"Lampert, Christoph"},{"first_name":"Hannes","last_name":"Nickisch","full_name":"Nickisch, Hannes"},{"last_name":"Harmeling","first_name":"Stefan","full_name":"Harmeling, Stefan"}]},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":"       337","abstract":[{"lang":"eng","text":"The Arabidopsis thaliana central cell, the companion cell of the egg, undergoes DNA demethylation before fertilization, but the targeting preferences, mechanism, and biological significance of this process remain unclear. Here, we show that active DNA demethylation mediated by the DEMETER DNA glycosylase accounts for all of the demethylation in the central cell and preferentially targets small, AT-rich, and nucleosome-depleted euchromatic transposable elements. The vegetative cell, the companion cell of sperm, also undergoes DEMETER-dependent demethylation of similar sequences, and lack of DEMETER in vegetative cells causes reduced small RNA–directed DNA methylation of transposons in sperm. Our results demonstrate that demethylation in companion cells reinforces transposon methylation in plant gametes and likely contributes to stable silencing of transposable elements across generations."}],"publication":"Science","status":"public","date_published":"2012-09-14T00:00:00Z","scopus_import":"1","date_created":"2023-01-16T09:21:24Z","oa_version":"Published Version","type":"journal_article","volume":337,"main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034762/","open_access":"1"}],"publication_status":"published","publisher":"American Association for the Advancement of Science","department":[{"_id":"XiFe"}],"quality_controlled":"1","pmid":1,"language":[{"iso":"eng"}],"_id":"12198","acknowledgement":"We thank S. Harmer for assistance with the analysis of histone modifications, the BioOptics team at the Vienna Biocenter Campus for sorting sperm and vegetative cell nuclei, K. Slotkin for the LAT52p-amiRNA=GFP plasmid, and G. Drews for the DD45p-GFP transgenic line. This work was partially funded by an NIH grant (GM69415) to R.L.F., NSF grants (MCB-0918821 and IOS-1025890) to R.L.F. and D.Z., a Young Investigator Grant from the Arnold and Mabel Beckman Foundation to D.Z., an Austrian Science Fund (FWF) grant P21389-B03 to H.T., a Ruth L. Kirschstein NIH Predoctoral Fellowship (GM093633) to C.A.I., a Fulbright Scholarship to J.A.R., a fellowship from the Jane Coffin Childs Memorial Fund to A.Z., and a Robert and Colleen Haas Scholarship to D.R. Sequencing data are deposited in GEO (GSE38935).","page":"1360-1364","issue":"6100","article_type":"original","citation":{"mla":"Ibarra, Christian A., et al. “Active DNA Demethylation in Plant Companion Cells Reinforces Transposon Methylation in Gametes.” <i>Science</i>, vol. 337, no. 6100, American Association for the Advancement of Science, 2012, pp. 1360–64, doi:<a href=\"https://doi.org/10.1126/science.1224839\">10.1126/science.1224839</a>.","short":"C.A. Ibarra, X. Feng, V.K. Schoft, T.-F. Hsieh, R. Uzawa, J.A. Rodrigues, A. Zemach, N. Chumak, A. Machlicova, T. Nishimura, D. Rojas, R.L. Fischer, H. Tamaru, D. Zilberman, Science 337 (2012) 1360–1364.","ieee":"C. A. Ibarra <i>et al.</i>, “Active DNA demethylation in plant companion cells reinforces transposon methylation in gametes,” <i>Science</i>, vol. 337, no. 6100. American Association for the Advancement of Science, pp. 1360–1364, 2012.","chicago":"Ibarra, Christian A., Xiaoqi Feng, Vera K. Schoft, Tzung-Fu Hsieh, Rie Uzawa, Jessica A. Rodrigues, Assaf Zemach, et al. “Active DNA Demethylation in Plant Companion Cells Reinforces Transposon Methylation in Gametes.” <i>Science</i>. American Association for the Advancement of Science, 2012. <a href=\"https://doi.org/10.1126/science.1224839\">https://doi.org/10.1126/science.1224839</a>.","apa":"Ibarra, C. A., Feng, X., Schoft, V. K., Hsieh, T.-F., Uzawa, R., Rodrigues, J. A., … Zilberman, D. (2012). Active DNA demethylation in plant companion cells reinforces transposon methylation in gametes. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1224839\">https://doi.org/10.1126/science.1224839</a>","ista":"Ibarra CA, Feng X, Schoft VK, Hsieh T-F, Uzawa R, Rodrigues JA, Zemach A, Chumak N, Machlicova A, Nishimura T, Rojas D, Fischer RL, Tamaru H, Zilberman D. 2012. Active DNA demethylation in plant companion cells reinforces transposon methylation in gametes. Science. 337(6100), 1360–1364.","ama":"Ibarra CA, Feng X, Schoft VK, et al. Active DNA demethylation in plant companion cells reinforces transposon methylation in gametes. <i>Science</i>. 2012;337(6100):1360-1364. doi:<a href=\"https://doi.org/10.1126/science.1224839\">10.1126/science.1224839</a>"},"keyword":["Multidisciplinary"],"author":[{"full_name":"Ibarra, Christian A.","first_name":"Christian A.","last_name":"Ibarra"},{"last_name":"Feng","first_name":"Xiaoqi","id":"e0164712-22ee-11ed-b12a-d80fcdf35958","full_name":"Feng, Xiaoqi","orcid":"0000-0002-4008-1234"},{"first_name":"Vera K.","last_name":"Schoft","full_name":"Schoft, Vera K."},{"full_name":"Hsieh, Tzung-Fu","first_name":"Tzung-Fu","last_name":"Hsieh"},{"full_name":"Uzawa, Rie","last_name":"Uzawa","first_name":"Rie"},{"first_name":"Jessica A.","last_name":"Rodrigues","full_name":"Rodrigues, Jessica A."},{"first_name":"Assaf","last_name":"Zemach","full_name":"Zemach, Assaf"},{"first_name":"Nina","last_name":"Chumak","full_name":"Chumak, Nina"},{"first_name":"Adriana","last_name":"Machlicova","full_name":"Machlicova, Adriana"},{"first_name":"Toshiro","last_name":"Nishimura","full_name":"Nishimura, Toshiro"},{"full_name":"Rojas, Denisse","first_name":"Denisse","last_name":"Rojas"},{"last_name":"Fischer","first_name":"Robert L.","full_name":"Fischer, Robert L."},{"full_name":"Tamaru, Hisashi","first_name":"Hisashi","last_name":"Tamaru"},{"first_name":"Daniel","last_name":"Zilberman","full_name":"Zilberman, Daniel"}],"month":"09","article_processing_charge":"No","oa":1,"year":"2012","day":"14","publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"date_updated":"2023-10-16T09:27:26Z","doi":"10.1126/science.1224839","title":"Active DNA demethylation in plant companion cells reinforces transposon methylation in gametes","external_id":{"pmid":["22984074"]}},{"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1029/2011WR010559"}],"type":"journal_article","volume":48,"quality_controlled":"1","publication_status":"published","publisher":"American Geophysical Union","abstract":[{"lang":"eng","text":"In the Dry Andes of central Chile, summer water resources originate mostly from snowmelt and ice melt. We use the physically based, spatially distributed hydrological model TOPKAPI to study the exchange between glaciers and climate in the upper Aconcagua River Basin during the summer season and identify the model parameters that are robust and transferable and those that are more dependent on calibration. TOPKAPI has recently been adapted to incorporate an enhanced temperature index approach for snow and ice melting. We suggest a calibration procedure that allows calibration of parameters in three steps by separating parameters governing distinct processes. We evaluate the parameters' transferability in time and in space by applying the model at two spatial scales. TOPKAPI's ability to simulate the relevant processes is tested against meteorological, ablation, and glacier runoff data measured on Juncal Norte Glacier during two glacier ablation seasons. The model was applied successfully to the climatic setting of the Dry Andes once its parameters were recalibrated. We found a clear distinction between parameters that are stable in time and those that need recalibration. The parameters of the melt model are transferable from one season to the other, while the parameters governing the extrapolation of meteorological input data and the routing of glacier meltwater need recalibration from one season to the other. Sensitivity analysis revealed that the model is most sensitive to the temperature lapse rate governing the extrapolation of air temperature from point measurements to the glacier scale and to the melt parameter that multiplies the shortwave radiation balance."}],"publication":"Water Resources Research","status":"public","date_published":"2012-03-01T00:00:00Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":"        48","oa_version":"Published Version","scopus_import":"1","extern":"1","date_created":"2023-02-20T08:17:39Z","year":"2012","article_processing_charge":"No","oa":1,"doi":"10.1029/2011wr010559","title":"Calibration of a physically based, spatially distributed hydrological model in a glacierized basin: On the use of knowledge from glaciometeorological processes to constrain model parameters","day":"01","publication_identifier":{"issn":["0043-1397"]},"date_updated":"2023-02-21T09:38:36Z","issue":"3","language":[{"iso":"eng"}],"_id":"12644","author":[{"full_name":"Ragettli, S.","first_name":"S.","last_name":"Ragettli"},{"full_name":"Pellicciotti, Francesca","id":"b28f055a-81ea-11ed-b70c-a9fe7f7b0e70","last_name":"Pellicciotti","first_name":"Francesca"}],"article_number":"W03509","month":"03","article_type":"original","citation":{"short":"S. Ragettli, F. Pellicciotti, Water Resources Research 48 (2012).","mla":"Ragettli, S., and Francesca Pellicciotti. “Calibration of a Physically Based, Spatially Distributed Hydrological Model in a Glacierized Basin: On the Use of Knowledge from Glaciometeorological Processes to Constrain Model Parameters.” <i>Water Resources Research</i>, vol. 48, no. 3, W03509, American Geophysical Union, 2012, doi:<a href=\"https://doi.org/10.1029/2011wr010559\">10.1029/2011wr010559</a>.","ieee":"S. Ragettli and F. Pellicciotti, “Calibration of a physically based, spatially distributed hydrological model in a glacierized basin: On the use of knowledge from glaciometeorological processes to constrain model parameters,” <i>Water Resources Research</i>, vol. 48, no. 3. American Geophysical Union, 2012.","chicago":"Ragettli, S., and Francesca Pellicciotti. “Calibration of a Physically Based, Spatially Distributed Hydrological Model in a Glacierized Basin: On the Use of Knowledge from Glaciometeorological Processes to Constrain Model Parameters.” <i>Water Resources Research</i>. American Geophysical Union, 2012. <a href=\"https://doi.org/10.1029/2011wr010559\">https://doi.org/10.1029/2011wr010559</a>.","apa":"Ragettli, S., &#38; Pellicciotti, F. (2012). Calibration of a physically based, spatially distributed hydrological model in a glacierized basin: On the use of knowledge from glaciometeorological processes to constrain model parameters. <i>Water Resources Research</i>. American Geophysical Union. <a href=\"https://doi.org/10.1029/2011wr010559\">https://doi.org/10.1029/2011wr010559</a>","ista":"Ragettli S, Pellicciotti F. 2012. Calibration of a physically based, spatially distributed hydrological model in a glacierized basin: On the use of knowledge from glaciometeorological processes to constrain model parameters. Water Resources Research. 48(3), W03509.","ama":"Ragettli S, Pellicciotti F. Calibration of a physically based, spatially distributed hydrological model in a glacierized basin: On the use of knowledge from glaciometeorological processes to constrain model parameters. <i>Water Resources Research</i>. 2012;48(3). doi:<a href=\"https://doi.org/10.1029/2011wr010559\">10.1029/2011wr010559</a>"}},{"date_updated":"2023-02-21T09:31:54Z","day":"01","publication_identifier":{"eissn":["1994-7151"],"issn":["0276-4741"]},"doi":"10.1659/mrd-journal-d-11-00092.1","title":"Challenges and uncertainties in hydrological modeling of remote Hindu Kush–Karakoram–Himalayan (HKH) basins: Suggestions for calibration strategies","oa":1,"article_processing_charge":"No","year":"2012","citation":{"mla":"Pellicciotti, Francesca, et al. “Challenges and Uncertainties in Hydrological Modeling of Remote Hindu Kush–Karakoram–Himalayan (HKH) Basins: Suggestions for Calibration Strategies.” <i>Mountain Research and Development</i>, vol. 32, no. 1, International Mountain Society, 2012, pp. 39–50, doi:<a href=\"https://doi.org/10.1659/mrd-journal-d-11-00092.1\">10.1659/mrd-journal-d-11-00092.1</a>.","short":"F. Pellicciotti, C. Buergi, W.W. Immerzeel, M. Konz, A.B. Shrestha, Mountain Research and Development 32 (2012) 39–50.","ieee":"F. Pellicciotti, C. Buergi, W. W. Immerzeel, M. Konz, and A. B. Shrestha, “Challenges and uncertainties in hydrological modeling of remote Hindu Kush–Karakoram–Himalayan (HKH) basins: Suggestions for calibration strategies,” <i>Mountain Research and Development</i>, vol. 32, no. 1. International Mountain Society, pp. 39–50, 2012.","chicago":"Pellicciotti, Francesca, Cyrill Buergi, Walter Willem Immerzeel, Markus Konz, and Arun B. Shrestha. “Challenges and Uncertainties in Hydrological Modeling of Remote Hindu Kush–Karakoram–Himalayan (HKH) Basins: Suggestions for Calibration Strategies.” <i>Mountain Research and Development</i>. International Mountain Society, 2012. <a href=\"https://doi.org/10.1659/mrd-journal-d-11-00092.1\">https://doi.org/10.1659/mrd-journal-d-11-00092.1</a>.","apa":"Pellicciotti, F., Buergi, C., Immerzeel, W. W., Konz, M., &#38; Shrestha, A. B. (2012). Challenges and uncertainties in hydrological modeling of remote Hindu Kush–Karakoram–Himalayan (HKH) basins: Suggestions for calibration strategies. <i>Mountain Research and Development</i>. International Mountain Society. <a href=\"https://doi.org/10.1659/mrd-journal-d-11-00092.1\">https://doi.org/10.1659/mrd-journal-d-11-00092.1</a>","ista":"Pellicciotti F, Buergi C, Immerzeel WW, Konz M, Shrestha AB. 2012. Challenges and uncertainties in hydrological modeling of remote Hindu Kush–Karakoram–Himalayan (HKH) basins: Suggestions for calibration strategies. Mountain Research and Development. 32(1), 39–50.","ama":"Pellicciotti F, Buergi C, Immerzeel WW, Konz M, Shrestha AB. Challenges and uncertainties in hydrological modeling of remote Hindu Kush–Karakoram–Himalayan (HKH) basins: Suggestions for calibration strategies. <i>Mountain Research and Development</i>. 2012;32(1):39-50. doi:<a href=\"https://doi.org/10.1659/mrd-journal-d-11-00092.1\">10.1659/mrd-journal-d-11-00092.1</a>"},"article_type":"original","author":[{"id":"b28f055a-81ea-11ed-b70c-a9fe7f7b0e70","last_name":"Pellicciotti","first_name":"Francesca","full_name":"Pellicciotti, Francesca"},{"first_name":"Cyrill","last_name":"Buergi","full_name":"Buergi, Cyrill"},{"first_name":"Walter Willem","last_name":"Immerzeel","full_name":"Immerzeel, Walter Willem"},{"full_name":"Konz, Markus","last_name":"Konz","first_name":"Markus"},{"last_name":"Shrestha","first_name":"Arun B.","full_name":"Shrestha, Arun B."}],"month":"02","language":[{"iso":"eng"}],"_id":"12646","issue":"1","page":"39-50","publisher":"International Mountain Society","publication_status":"published","quality_controlled":"1","type":"journal_article","volume":32,"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1659/MRD-JOURNAL-D-11-00092.1"}],"date_created":"2023-02-20T08:17:47Z","extern":"1","scopus_import":"1","oa_version":"Published Version","intvolume":"        32","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication":"Mountain Research and Development","status":"public","date_published":"2012-02-01T00:00:00Z","abstract":[{"lang":"eng","text":"Assessment of water resources from remote mountainous catchments plays a crucial role for the development of rural areas in or in the vicinity of mountain ranges. The scarcity of data, however, prevents the application of standard approaches that are based on data-driven models. The Hindu Kush–Karakoram–Himalaya mountain range is a crucial area in terms of water resources, but our understanding of the response of its high-elevation catchments to a changing climate is hindered by lack of hydro-meteorological and cryospheric data. Hydrological modeling is challenging here because internal inconsistencies—such as an underestimation of precipitation input that can be compensated for by an overestimation of meltwater—might be hidden due to the complexity of feedback mechanisms that govern melt and runoff generation in such basins. Data scarcity adds to this difficulty by preventing the application of systematic calibration procedures that would allow identification of the parameter set that could guarantee internal consistency in the simulation of the single hydrological components. In this work, we use simulations from the Hunza River Basin in the Karakoram region obtained with the hydrological model TOPKAPI to quantify the predictive power of discharge and snow-cover data sets, as well as the combination of both. We also show that short-term measurements of meteorological variables such as radiative fluxes, wind speed, relative humidity, and air temperature from glacio-meteorological experiments are crucial for a correct parameterization of surface melt processes. They enable detailed simulations of the energy fluxes governing glacier–atmosphere interaction and the resulting ablation through energy-balance modeling. These simulations are used to derive calibrated parameters for the simplified snow and glacier routines in TOPKAPI. We demonstrate that such parameters are stable in space and time in similar climatic regions, thus reducing the number of parameters requiring calibration."}]},{"article_processing_charge":"No","oa":1,"year":"2012","date_updated":"2023-02-21T08:56:29Z","day":"01","publication_identifier":{"issn":["0276-4741"],"eissn":["1994-7151"]},"doi":"10.1659/mrd-journal-d-11-00097.1","title":"Glaciers as a proxy to quantify the spatial distribution of precipitation in the Hunza basin","_id":"12647","language":[{"iso":"eng"}],"issue":"1","page":"30-38","keyword":["General Environmental Science","Development","Environmental Chemistry"],"citation":{"ieee":"W. W. Immerzeel, F. Pellicciotti, and A. B. Shrestha, “Glaciers as a proxy to quantify the spatial distribution of precipitation in the Hunza basin,” <i>Mountain Research and Development</i>, vol. 32, no. 1. International Mountain Society, pp. 30–38, 2012.","chicago":"Immerzeel, Walter Willem, Francesca Pellicciotti, and Arun B. Shrestha. “Glaciers as a Proxy to Quantify the Spatial Distribution of Precipitation in the Hunza Basin.” <i>Mountain Research and Development</i>. International Mountain Society, 2012. <a href=\"https://doi.org/10.1659/mrd-journal-d-11-00097.1\">https://doi.org/10.1659/mrd-journal-d-11-00097.1</a>.","short":"W.W. Immerzeel, F. Pellicciotti, A.B. Shrestha, Mountain Research and Development 32 (2012) 30–38.","mla":"Immerzeel, Walter Willem, et al. “Glaciers as a Proxy to Quantify the Spatial Distribution of Precipitation in the Hunza Basin.” <i>Mountain Research and Development</i>, vol. 32, no. 1, International Mountain Society, 2012, pp. 30–38, doi:<a href=\"https://doi.org/10.1659/mrd-journal-d-11-00097.1\">10.1659/mrd-journal-d-11-00097.1</a>.","ama":"Immerzeel WW, Pellicciotti F, Shrestha AB. Glaciers as a proxy to quantify the spatial distribution of precipitation in the Hunza basin. <i>Mountain Research and Development</i>. 2012;32(1):30-38. doi:<a href=\"https://doi.org/10.1659/mrd-journal-d-11-00097.1\">10.1659/mrd-journal-d-11-00097.1</a>","apa":"Immerzeel, W. W., Pellicciotti, F., &#38; Shrestha, A. B. (2012). Glaciers as a proxy to quantify the spatial distribution of precipitation in the Hunza basin. <i>Mountain Research and Development</i>. International Mountain Society. <a href=\"https://doi.org/10.1659/mrd-journal-d-11-00097.1\">https://doi.org/10.1659/mrd-journal-d-11-00097.1</a>","ista":"Immerzeel WW, Pellicciotti F, Shrestha AB. 2012. Glaciers as a proxy to quantify the spatial distribution of precipitation in the Hunza basin. Mountain Research and Development. 32(1), 30–38."},"article_type":"original","author":[{"last_name":"Immerzeel","first_name":"Walter Willem","full_name":"Immerzeel, Walter Willem"},{"id":"b28f055a-81ea-11ed-b70c-a9fe7f7b0e70","first_name":"Francesca","last_name":"Pellicciotti","full_name":"Pellicciotti, Francesca"},{"first_name":"Arun B.","last_name":"Shrestha","full_name":"Shrestha, Arun B."}],"month":"02","type":"journal_article","volume":32,"main_file_link":[{"url":"https://doi.org/10.1659/MRD-JOURNAL-D-11-00097.1","open_access":"1"}],"publisher":"International Mountain Society","publication_status":"published","quality_controlled":"1","intvolume":"        32","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication":"Mountain Research and Development","status":"public","date_published":"2012-02-01T00:00:00Z","abstract":[{"text":"Accurate quantification of the spatial distribution of precipitation in mountain regions is crucial for assessments of water resources and for the understanding of high-altitude hydrology, yet it is one of the largest unknowns due to the lack of high-altitude observations. The Hunza basin in Pakistan contains very large glacier systems, which, given the melt, cannot persist unless precipitation (snow input) is much higher than what is observed at the meteorological stations, mostly located in mountain valleys. Several studies, therefore, suggest strong positive vertical precipitation lapse rates; in the present study, we quantify this lapse rate by using glaciers as a proxy. We assume a neutral mass balance for the glaciers for the period from 2001 to 2003, and we inversely model the precipitation lapse by balancing the total accumulation in the catchment area and the ablation over the glacier area for the 50 largest glacier systems in the Hunza basin in the Karakoram. Our results reveal a vertical precipitation lapse rate that equals 0.21 ± 0.12% m−1, with a maximum precipitation at an elevation of 5500 masl. We showed that the total annual basin precipitation (828 mm) is 260% higher than what is estimated based on interpolated observations (319 mm); this has major consequences for hydrological modeling and water resource assessments in general. Our results were validated by using previously published studies on individual glaciers as well as the water balance of the Hunza basin. The approach is more widely applicable in mountain ranges where precipitation measurements at high altitude are lacking.","lang":"eng"}],"date_created":"2023-02-20T08:17:52Z","scopus_import":"1","extern":"1","oa_version":"Published Version"},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":"       117","abstract":[{"text":"Distributed glacier melt models generally assume that the glacier surface consists of bare exposed ice and snow. In reality, many glaciers are wholly or partially covered in layers of debris that tend to suppress ablation rates. In this paper, an existing physically based point model for the ablation of debris-covered ice is incorporated in a distributed melt model and applied to Haut Glacier d'Arolla, Switzerland, which has three large patches of debris cover on its surface. The model is based on a 10 m resolution digital elevation model (DEM) of the area; each glacier pixel in the DEM is defined as either bare or debris-covered ice, and may be covered in snow that must be melted off before ice ablation is assumed to occur. Each debris-covered pixel is assigned a debris thickness value using probability distributions based on over 1000 manual thickness measurements. Locally observed meteorological data are used to run energy balance calculations in every pixel, using an approach suitable for snow, bare ice or debris-covered ice as appropriate. The use of the debris model significantly reduces the total ablation in the debris-covered areas, however the precise reduction is sensitive to the temperature extrapolation used in the model distribution because air near the debris surface tends to be slightly warmer than over bare ice. Overall results suggest that the debris patches, which cover 10% of the glacierized area, reduce total runoff from the glacierized part of the basin by up to 7%.","lang":"eng"}],"status":"public","date_published":"2012-09-27T00:00:00Z","publication":"Journal of Geophysical Research: Atmospheres","scopus_import":"1","extern":"1","date_created":"2023-02-20T08:17:57Z","oa_version":"Published Version","volume":117,"type":"journal_article","main_file_link":[{"url":"https://doi.org/10.1029/2012JD017795","open_access":"1"}],"publication_status":"published","publisher":"American Geophysical Union","quality_controlled":"1","_id":"12648","language":[{"iso":"eng"}],"issue":"D18","article_type":"original","citation":{"apa":"Reid, T. D., Carenzo, M., Pellicciotti, F., &#38; Brock, B. W. (2012). Including debris cover effects in a distributed model of glacier ablation. <i>Journal of Geophysical Research: Atmospheres</i>. American Geophysical Union. <a href=\"https://doi.org/10.1029/2012jd017795\">https://doi.org/10.1029/2012jd017795</a>","ista":"Reid TD, Carenzo M, Pellicciotti F, Brock BW. 2012. Including debris cover effects in a distributed model of glacier ablation. Journal of Geophysical Research: Atmospheres. 117(D18), D18105.","ama":"Reid TD, Carenzo M, Pellicciotti F, Brock BW. Including debris cover effects in a distributed model of glacier ablation. <i>Journal of Geophysical Research: Atmospheres</i>. 2012;117(D18). doi:<a href=\"https://doi.org/10.1029/2012jd017795\">10.1029/2012jd017795</a>","short":"T.D. Reid, M. Carenzo, F. Pellicciotti, B.W. Brock, Journal of Geophysical Research: Atmospheres 117 (2012).","mla":"Reid, T. D., et al. “Including Debris Cover Effects in a Distributed Model of Glacier Ablation.” <i>Journal of Geophysical Research: Atmospheres</i>, vol. 117, no. D18, D18105, American Geophysical Union, 2012, doi:<a href=\"https://doi.org/10.1029/2012jd017795\">10.1029/2012jd017795</a>.","ieee":"T. D. Reid, M. Carenzo, F. Pellicciotti, and B. W. Brock, “Including debris cover effects in a distributed model of glacier ablation,” <i>Journal of Geophysical Research: Atmospheres</i>, vol. 117, no. D18. American Geophysical Union, 2012.","chicago":"Reid, T. D., M. Carenzo, Francesca Pellicciotti, and B. W. Brock. “Including Debris Cover Effects in a Distributed Model of Glacier Ablation.” <i>Journal of Geophysical Research: Atmospheres</i>. American Geophysical Union, 2012. <a href=\"https://doi.org/10.1029/2012jd017795\">https://doi.org/10.1029/2012jd017795</a>."},"keyword":["Paleontology","Space and Planetary Science","Earth and Planetary Sciences (miscellaneous)","Atmospheric Science","Earth-Surface Processes","Geochemistry and Petrology","Soil Science","Water Science and Technology","Ecology","Aquatic Science","Forestry","Oceanography","Geophysics"],"article_number":"D18105","month":"09","author":[{"last_name":"Reid","first_name":"T. D.","full_name":"Reid, T. D."},{"full_name":"Carenzo, M.","first_name":"M.","last_name":"Carenzo"},{"full_name":"Pellicciotti, Francesca","last_name":"Pellicciotti","first_name":"Francesca","id":"b28f055a-81ea-11ed-b70c-a9fe7f7b0e70"},{"full_name":"Brock, B. W.","last_name":"Brock","first_name":"B. W."}],"oa":1,"article_processing_charge":"No","year":"2012","publication_identifier":{"issn":["0148-0227"]},"day":"27","date_updated":"2023-02-20T10:57:31Z","title":"Including debris cover effects in a distributed model of glacier ablation","doi":"10.1029/2012jd017795"},{"doi":"10.5061/DRYAD.0G0FS","title":"Data from: A likelihood-based comparison of population histories in a parasitoid guild","department":[{"_id":"NiBa"}],"date_updated":"2025-05-28T11:56:58Z","publisher":"Dryad","day":"08","main_file_link":[{"url":"https://doi.org/10.5061/dryad.0g0fs","open_access":"1"}],"year":"2012","related_material":{"record":[{"status":"public","relation":"used_in_publication","id":"2968"}]},"oa":1,"article_processing_charge":"No","type":"research_data_reference","oa_version":"Published Version","author":[{"full_name":"Lohse, Konrad","last_name":"Lohse","first_name":"Konrad"},{"full_name":"Barton, Nicholas H","orcid":"0000-0002-8548-5240","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","last_name":"Barton","first_name":"Nicholas H"},{"full_name":"Stone, Graham","last_name":"Stone","first_name":"Graham"},{"full_name":"Melika, George","first_name":"George","last_name":"Melika"}],"month":"06","ddc":["570"],"citation":{"ama":"Lohse K, Barton NH, Stone G, Melika G. Data from: A likelihood-based comparison of population histories in a parasitoid guild. 2012. doi:<a href=\"https://doi.org/10.5061/DRYAD.0G0FS\">10.5061/DRYAD.0G0FS</a>","apa":"Lohse, K., Barton, N. H., Stone, G., &#38; Melika, G. (2012). Data from: A likelihood-based comparison of population histories in a parasitoid guild. Dryad. <a href=\"https://doi.org/10.5061/DRYAD.0G0FS\">https://doi.org/10.5061/DRYAD.0G0FS</a>","ista":"Lohse K, Barton NH, Stone G, Melika G. 2012. Data from: A likelihood-based comparison of population histories in a parasitoid guild, Dryad, <a href=\"https://doi.org/10.5061/DRYAD.0G0FS\">10.5061/DRYAD.0G0FS</a>.","ieee":"K. Lohse, N. H. Barton, G. Stone, and G. Melika, “Data from: A likelihood-based comparison of population histories in a parasitoid guild.” Dryad, 2012.","chicago":"Lohse, Konrad, Nicholas H Barton, Graham Stone, and George Melika. “Data from: A Likelihood-Based Comparison of Population Histories in a Parasitoid Guild.” Dryad, 2012. <a href=\"https://doi.org/10.5061/DRYAD.0G0FS\">https://doi.org/10.5061/DRYAD.0G0FS</a>.","short":"K. Lohse, N.H. Barton, G. Stone, G. Melika, (2012).","mla":"Lohse, Konrad, et al. <i>Data from: A Likelihood-Based Comparison of Population Histories in a Parasitoid Guild</i>. Dryad, 2012, doi:<a href=\"https://doi.org/10.5061/DRYAD.0G0FS\">10.5061/DRYAD.0G0FS</a>."},"date_created":"2023-05-23T17:01:02Z","status":"public","date_published":"2012-06-08T00:00:00Z","abstract":[{"text":"Little is known about the stability of trophic relationships in complex natural communities over evolutionary timescales. Here, we use sequence data from 18 nuclear loci to reconstruct and compare the intraspecific histories of major Pleistocene refugial populations in the Middle East, the Balkans and Iberia in a guild of four Chalcid parasitoids (Cecidostiba fungosa, C. semifascia, Hobbya stenonota and Mesopolobus amaenus) all attacking Cynipid oak galls. We develop a likelihood method to numerically estimate models of divergence between three populations from multilocus data. We investigate the power of this framework on simulated data, and - using triplet alignments of intronic loci - quantify the support for all possible divergence relationships between refugial populations in the four parasitoids. Although an East to West order of population divergence has highest support in all but one species, we cannot rule out alternative population tree topologies. Comparing the estimated times of population splits between species, we find that one species, M. amaenus, has a significantly older history than the rest of the guild and must have arrived in central Europe at least one glacial cycle prior to other guild members. This suggests that although all four species may share a common origin in the East, they expanded westwards into Europe at different times.","lang":"eng"}],"tmp":{"name":"Creative Commons Public Domain Dedication (CC0 1.0)","short":"CC0 (1.0)","legal_code_url":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","image":"/images/cc_0.png"},"_id":"13075","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"},{"publisher":"Oxford University Press","publication_status":"published","pmid":1,"quality_controlled":"1","volume":333,"type":"journal_article","date_created":"2020-08-10T11:54:47Z","extern":"1","oa_version":"None","intvolume":"       333","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_published":"2012-08-01T00:00:00Z","status":"public","publication":"FEMS Microbiology Letters","abstract":[{"lang":"eng","text":"The Staphylococcus aureus cell wall stress stimulon (CWSS) is activated by cell envelope-targeting antibiotics or depletion of essential cell wall biosynthesis enzymes. The functionally uncharacterized S. aureus LytR-CpsA-Psr (LCP) proteins, MsrR, SA0908 and SA2103, all belong to the CWSS. Although not essential, deletion of all three LCP proteins severely impairs cell division. We show here that VraSR-dependent CWSS expression was up to 250-fold higher in single, double and triple LCP mutants than in wild type S. aureus in the absence of external stress. The LCP triple mutant was virtually depleted of wall teichoic acids (WTA), which could be restored to different degrees by any of the single LCP proteins. Subinhibitory concentrations of tunicamycin, which inhibits the first WTA synthesis enzyme TarO (TagO), could partially complement the severe growth defect of the LCP triple mutant. Both of the latter findings support a role for S. aureus LCP proteins in late WTA synthesis, as in Bacillus subtilis where LCP proteins were recently proposed to transfer WTA from lipid carriers to the cell wall peptidoglycan. Intrinsic activation of the CWSS upon LCP deletion and the fact that LCP proteins were essential for WTA-loading of the cell wall, highlight their important role(s) in S. aureus cell envelope biogenesis."}],"date_updated":"2021-01-12T08:17:43Z","publication_identifier":{"issn":["0378-1097"]},"day":"01","external_id":{"pmid":["22640011"]},"title":"Deletion of hypothetical wall teichoic acid ligases in Staphylococcus aureus activates the cell wall stress response","doi":"10.1111/j.1574-6968.2012.02603.x","article_processing_charge":"No","year":"2012","citation":{"ama":"Dengler V, Meier PS, Heusser R, et al. Deletion of hypothetical wall teichoic acid ligases in Staphylococcus aureus activates the cell wall stress response. <i>FEMS Microbiology Letters</i>. 2012;333(2):109-120. doi:<a href=\"https://doi.org/10.1111/j.1574-6968.2012.02603.x\">10.1111/j.1574-6968.2012.02603.x</a>","apa":"Dengler, V., Meier, P. S., Heusser, R., Kupferschmied, P., Singer, J., Friebe, S., … McCallum, N. (2012). Deletion of hypothetical wall teichoic acid ligases in Staphylococcus aureus activates the cell wall stress response. <i>FEMS Microbiology Letters</i>. Oxford University Press. <a href=\"https://doi.org/10.1111/j.1574-6968.2012.02603.x\">https://doi.org/10.1111/j.1574-6968.2012.02603.x</a>","ista":"Dengler V, Meier PS, Heusser R, Kupferschmied P, Singer J, Friebe S, Staufer SB, Majcherczyk PA, Moreillon P, Berger-Bächi B, McCallum N. 2012. Deletion of hypothetical wall teichoic acid ligases in Staphylococcus aureus activates the cell wall stress response. FEMS Microbiology Letters. 333(2), 109–120.","ieee":"V. Dengler <i>et al.</i>, “Deletion of hypothetical wall teichoic acid ligases in Staphylococcus aureus activates the cell wall stress response,” <i>FEMS Microbiology Letters</i>, vol. 333, no. 2. Oxford University Press, pp. 109–120, 2012.","chicago":"Dengler, Vanina, Patricia Stutzmann Meier, Ronald Heusser, Peter Kupferschmied, Judit Singer, Sarah Friebe, Sibylle Burger Staufer, et al. “Deletion of Hypothetical Wall Teichoic Acid Ligases in Staphylococcus Aureus Activates the Cell Wall Stress Response.” <i>FEMS Microbiology Letters</i>. Oxford University Press, 2012. <a href=\"https://doi.org/10.1111/j.1574-6968.2012.02603.x\">https://doi.org/10.1111/j.1574-6968.2012.02603.x</a>.","mla":"Dengler, Vanina, et al. “Deletion of Hypothetical Wall Teichoic Acid Ligases in Staphylococcus Aureus Activates the Cell Wall Stress Response.” <i>FEMS Microbiology Letters</i>, vol. 333, no. 2, Oxford University Press, 2012, pp. 109–20, doi:<a href=\"https://doi.org/10.1111/j.1574-6968.2012.02603.x\">10.1111/j.1574-6968.2012.02603.x</a>.","short":"V. Dengler, P.S. Meier, R. Heusser, P. Kupferschmied, J. Singer, S. Friebe, S.B. Staufer, P.A. Majcherczyk, P. Moreillon, B. Berger-Bächi, N. McCallum, FEMS Microbiology Letters 333 (2012) 109–120."},"article_type":"original","month":"08","author":[{"first_name":"Vanina","last_name":"Dengler","full_name":"Dengler, Vanina"},{"full_name":"Meier, Patricia Stutzmann","first_name":"Patricia Stutzmann","last_name":"Meier"},{"full_name":"Heusser, Ronald","first_name":"Ronald","last_name":"Heusser"},{"last_name":"Kupferschmied","first_name":"Peter","full_name":"Kupferschmied, Peter"},{"id":"36432834-F248-11E8-B48F-1D18A9856A87","last_name":"Fazekas","first_name":"Judit","full_name":"Fazekas, Judit","orcid":"0000-0002-8777-3502"},{"first_name":"Sarah","last_name":"Friebe","full_name":"Friebe, Sarah"},{"full_name":"Staufer, Sibylle Burger","last_name":"Staufer","first_name":"Sibylle Burger"},{"last_name":"Majcherczyk","first_name":"Paul A.","full_name":"Majcherczyk, Paul A."},{"full_name":"Moreillon, Philippe","first_name":"Philippe","last_name":"Moreillon"},{"last_name":"Berger-Bächi","first_name":"Brigitte","full_name":"Berger-Bächi, Brigitte"},{"last_name":"McCallum","first_name":"Nadine","full_name":"McCallum, Nadine"}],"_id":"8246","language":[{"iso":"eng"}],"issue":"2","page":"109-120"},{"extern":1,"citation":{"ieee":"M. Vanstraelen and E. Benková, “Hormonal interactions in the regulation of plant development,” <i>Annual Review of Cell and Developmental Biology</i>, vol. 28. Annual Reviews, pp. 463–487, 2012.","chicago":"Vanstraelen, Marleen, and Eva Benková. “Hormonal Interactions in the Regulation of Plant Development.” <i>Annual Review of Cell and Developmental Biology</i>. Annual Reviews, 2012. <a href=\"https://doi.org/10.1146/annurev-cellbio-101011-155741\">https://doi.org/10.1146/annurev-cellbio-101011-155741</a>.","mla":"Vanstraelen, Marleen, and Eva Benková. “Hormonal Interactions in the Regulation of Plant Development.” <i>Annual Review of Cell and Developmental Biology</i>, vol. 28, Annual Reviews, 2012, pp. 463–87, doi:<a href=\"https://doi.org/10.1146/annurev-cellbio-101011-155741\">10.1146/annurev-cellbio-101011-155741</a>.","short":"M. Vanstraelen, E. Benková, Annual Review of Cell and Developmental Biology 28 (2012) 463–487.","ama":"Vanstraelen M, Benková E. Hormonal interactions in the regulation of plant development. <i>Annual Review of Cell and Developmental Biology</i>. 2012;28:463-487. doi:<a href=\"https://doi.org/10.1146/annurev-cellbio-101011-155741\">10.1146/annurev-cellbio-101011-155741</a>","apa":"Vanstraelen, M., &#38; Benková, E. (2012). Hormonal interactions in the regulation of plant development. <i>Annual Review of Cell and Developmental Biology</i>. Annual Reviews. <a href=\"https://doi.org/10.1146/annurev-cellbio-101011-155741\">https://doi.org/10.1146/annurev-cellbio-101011-155741</a>","ista":"Vanstraelen M, Benková E. 2012. Hormonal interactions in the regulation of plant development. Annual Review of Cell and Developmental Biology. 28, 463–487."},"date_created":"2018-12-11T11:48:43Z","author":[{"full_name":"Vanstraelen, Marleen","last_name":"Vanstraelen","first_name":"Marleen"},{"orcid":"0000-0002-8510-9739","full_name":"Eva Benková","id":"38F4F166-F248-11E8-B48F-1D18A9856A87","last_name":"Benková","first_name":"Eva"}],"month":"11","intvolume":"        28","_id":"826","acknowledgement":"We would like to thank Annick Bleys for help in preparing the manuscript. This work was supported by the European Research Council with a Starting Independent Research grant (ERC-2007-Stg-207362-HCPO) and the project CZ.1.07/2.3.00/20.0043 (to the Central European Institute of Technology, CEITEC) to E.B. M.V. is a postdoctoral fellow of the Research Foundation Flanders. We apologize that, because of space restrictions, the scientific contributions of only a limited number of original articles could be cited and discussed.","page":"463 - 487","abstract":[{"lang":"eng","text":"Plants exhibit a unique developmental flexibility to ever-changing environmental conditions. To achieve their profound adaptability, plants are able to maintain permanent stem cell populations and form new organs during the entire plant life cycle. Signaling substances, called plant hormones, such as auxin, cytokinin, abscisic acid, brassinosteroid, ethylene, gibberellin, jasmonic acid, and strigolactone, govern and coordinate these developmental processes. Physiological and genetic studies have dissected the molecular components of signal perception and transduction of the individual hormonal pathways. However, over recent years it has become evident that hormones do not act only in a linear pathway. Hormonal pathways are interconnected by a complex network of interactions and feedback circuits that determines the final outcome of the individual hormone actions. This raises questions about the molecular mechanisms underlying hormonal cross talk and about how these hormonal networks are established, maintained, and modulated throughout plant development."}],"publication":"Annual Review of Cell and Developmental Biology","publist_id":"6822","status":"public","date_published":"2012-11-01T00:00:00Z","day":"01","publication_status":"published","date_updated":"2021-01-12T08:17:46Z","publisher":"Annual Reviews","doi":"10.1146/annurev-cellbio-101011-155741","title":"Hormonal interactions in the regulation of plant development","quality_controlled":0,"type":"journal_article","volume":28,"year":"2012"},{"quality_controlled":0,"title":"Spatiotemporal regulation of lateral root organogenesis in Arabidopsis by cytokinin","doi":"10.1105/tpc.112.103044","publisher":"American Society of Plant Biologists","date_updated":"2021-01-12T08:17:55Z","publication_status":"published","day":"01","year":"2012","volume":24,"type":"journal_article","month":"10","author":[{"full_name":"Bielach, Agnieszka","first_name":"Agnieszka","last_name":"Bielach"},{"full_name":"Podlesakova, Katerina","first_name":"Katerina","last_name":"Podlesakova"},{"full_name":"Peter Marhavy","orcid":"0000-0001-5227-5741","id":"3F45B078-F248-11E8-B48F-1D18A9856A87","first_name":"Peter","last_name":"Marhavy"},{"full_name":"Duclercq, Jérôme","first_name":"Jérôme","last_name":"Duclercq"},{"first_name":"Candela","last_name":"Cuesta","id":"33A3C818-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-1923-2410","full_name":"Candela Cuesta"},{"full_name":"Muller, Bruno","first_name":"Bruno","last_name":"Muller"},{"last_name":"Grunewald","first_name":"Wim","full_name":"Grunewald, Wim"},{"first_name":"Petr","last_name":"Tarkowski","full_name":"Tarkowski, Petr"},{"full_name":"Eva Benková","orcid":"0000-0002-8510-9739","id":"38F4F166-F248-11E8-B48F-1D18A9856A87","last_name":"Benková","first_name":"Eva"}],"citation":{"ama":"Bielach A, Podlesakova K, Marhavý P, et al. Spatiotemporal regulation of lateral root organogenesis in Arabidopsis by cytokinin. <i>The Plant Cell</i>. 2012;24(10):3967-3981. doi:<a href=\"https://doi.org/10.1105/tpc.112.103044\">10.1105/tpc.112.103044</a>","apa":"Bielach, A., Podlesakova, K., Marhavý, P., Duclercq, J., Cuesta, C., Muller, B., … Benková, E. (2012). Spatiotemporal regulation of lateral root organogenesis in Arabidopsis by cytokinin. <i>The Plant Cell</i>. American Society of Plant Biologists. <a href=\"https://doi.org/10.1105/tpc.112.103044\">https://doi.org/10.1105/tpc.112.103044</a>","ista":"Bielach A, Podlesakova K, Marhavý P, Duclercq J, Cuesta C, Muller B, Grunewald W, Tarkowski P, Benková E. 2012. Spatiotemporal regulation of lateral root organogenesis in Arabidopsis by cytokinin. The Plant Cell. 24(10), 3967–3981.","ieee":"A. Bielach <i>et al.</i>, “Spatiotemporal regulation of lateral root organogenesis in Arabidopsis by cytokinin,” <i>The Plant Cell</i>, vol. 24, no. 10. American Society of Plant Biologists, pp. 3967–3981, 2012.","chicago":"Bielach, Agnieszka, Katerina Podlesakova, Peter Marhavý, Jérôme Duclercq, Candela Cuesta, Bruno Muller, Wim Grunewald, Petr Tarkowski, and Eva Benková. “Spatiotemporal Regulation of Lateral Root Organogenesis in Arabidopsis by Cytokinin.” <i>The Plant Cell</i>. American Society of Plant Biologists, 2012. <a href=\"https://doi.org/10.1105/tpc.112.103044\">https://doi.org/10.1105/tpc.112.103044</a>.","short":"A. Bielach, K. Podlesakova, P. Marhavý, J. Duclercq, C. Cuesta, B. Muller, W. Grunewald, P. Tarkowski, E. Benková, The Plant Cell 24 (2012) 3967–3981.","mla":"Bielach, Agnieszka, et al. “Spatiotemporal Regulation of Lateral Root Organogenesis in Arabidopsis by Cytokinin.” <i>The Plant Cell</i>, vol. 24, no. 10, American Society of Plant Biologists, 2012, pp. 3967–81, doi:<a href=\"https://doi.org/10.1105/tpc.112.103044\">10.1105/tpc.112.103044</a>."},"date_created":"2018-12-11T11:48:43Z","extern":1,"status":"public","date_published":"2012-10-01T00:00:00Z","issue":"10","publist_id":"6819","publication":"The Plant Cell","abstract":[{"text":"The architecture of a plant's root system, established postembryonically, results from both coordinated root growth and lateral root branching. The plant hormones auxin and cytokinin are central endogenous signaling molecules that regulate lateral root organogenesis positively and negatively, respectively. Tight control and mutual balance of their antagonistic activities are particularly important during the early phases of lateral root organogenesis to ensure continuous lateral root initiation (LRI) and proper development of lateral root primordia (LRP). Here, we show that the early phases of lateral root organogenesis, including priming and initiation, take place in root zones with a repressed cytokinin response. Accordingly, ectopic overproduction of cytokinin in the root basal meristem most efficiently inhibits LRI. Enhanced cytokinin responses in pericycle cells between existing LRP might restrict LRI near existing LRP and, when compromised, ectopic LRI occurs. Furthermore, our results demonstrate that young LRP are more sensitive to perturbations in the cytokinin activity than are developmentally more advanced primordia. We hypothesize that the effect of cytokinin on the development of primordia possibly depends on the robustness and stability of the auxin gradient.","lang":"eng"}],"page":"3967 - 3981","acknowledgement":"We thank Jen Sheen, Dolf Weijers, Tatsuo Kakimoto, Stephen Depuydt, and Laurent Laplaze for sharing published material, Jiri Friml for discussions, and Martine De Cock and Annick Bleys for help in preparing the manuscript. This work was supported by a Starting Independent Research grant from the European Research Council (ERC-2007-Stg-207362-HCPO) and the project CZ.1.07/2.3.00/20.0043 to the Central European Institute of Technology to E.B. and grants from the Ministry of Education, Youth, and Sports of the Czech Republic (MSM 6198959216) and the Centre of the Region Haná for Biotechnological and Agricultural Research (ED0007/01/01) to P.T.","_id":"829","intvolume":"        24"},{"date_updated":"2021-01-12T08:19:25Z","publisher":"Oxford University Press","day":"01","publication_status":"published","quality_controlled":0,"doi":"10.1093/gbe/evs096","title":"Estimating the rate of irreversibility in protein evolution","type":"journal_article","volume":4,"year":"2012","date_created":"2018-12-11T11:48:49Z","citation":{"short":"O. Soylemez, F. Kondrashov, Genome Biology and Evolution 4 (2012) 1213–1222.","mla":"Soylemez, Onuralp, and Fyodor Kondrashov. “Estimating the Rate of Irreversibility in Protein Evolution.” <i>Genome Biology and Evolution</i>, vol. 4, no. 12, Oxford University Press, 2012, pp. 1213–22, doi:<a href=\"https://doi.org/10.1093/gbe/evs096\">10.1093/gbe/evs096</a>.","chicago":"Soylemez, Onuralp, and Fyodor Kondrashov. “Estimating the Rate of Irreversibility in Protein Evolution.” <i>Genome Biology and Evolution</i>. Oxford University Press, 2012. <a href=\"https://doi.org/10.1093/gbe/evs096\">https://doi.org/10.1093/gbe/evs096</a>.","ieee":"O. Soylemez and F. Kondrashov, “Estimating the rate of irreversibility in protein evolution,” <i>Genome Biology and Evolution</i>, vol. 4, no. 12. Oxford University Press, pp. 1213–1222, 2012.","ista":"Soylemez O, Kondrashov F. 2012. Estimating the rate of irreversibility in protein evolution. Genome Biology and Evolution. 4(12), 1213–1222.","apa":"Soylemez, O., &#38; Kondrashov, F. (2012). Estimating the rate of irreversibility in protein evolution. <i>Genome Biology and Evolution</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/gbe/evs096\">https://doi.org/10.1093/gbe/evs096</a>","ama":"Soylemez O, Kondrashov F. Estimating the rate of irreversibility in protein evolution. <i>Genome Biology and Evolution</i>. 2012;4(12):1213-1222. doi:<a href=\"https://doi.org/10.1093/gbe/evs096\">10.1093/gbe/evs096</a>"},"extern":1,"author":[{"full_name":"Soylemez, Onuralp","last_name":"Soylemez","first_name":"Onuralp"},{"id":"44FDEF62-F248-11E8-B48F-1D18A9856A87","last_name":"Kondrashov","first_name":"Fyodor","full_name":"Fyodor Kondrashov","orcid":"0000-0001-8243-4694"}],"month":"01","intvolume":"         4","license":"https://creativecommons.org/licenses/by-nc/4.0/","tmp":{"image":"/images/cc_by_nc.png","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","short":"CC BY-NC (4.0)"},"_id":"846","acknowledgement":"This work was supported by Plan Nacional grant BFU2009-09271 from the Spanish Ministry of Science and Innovation and by FPU (Formación del Profesorado Universitario) program grant AP2008-01888 from the Spanish Ministry of Education to O.S. F.A.K. is a European Molecular Biology Organization Young Investigator and Howard Hughes Medical Institute International Early Career Scientist.","publist_id":"6802","issue":"12","publication":"Genome Biology and Evolution","date_published":"2012-01-01T00:00:00Z","status":"public","page":"1213 - 1222","abstract":[{"lang":"eng","text":"Whether or not evolutionary change is inherently irreversible remains a controversial topic. Some examples of evolutionary irreversibility are known; however, this question has not been comprehensively addressed at the molecular level. Here, we use data from 221 human genes with known pathogenic mutations to estimate the rate of irreversibility in protein evolution. For these genes, we reconstruct ancestral amino acid sequences along the mammalian phylogeny and identify ancestral amino acid states that match known pathogenic mutations. Such cases represent inherent evolutionary irreversibility because, at the present moment, reversals to these ancestral amino acid states are impossible for the human lineage. We estimate that approximately 10% of all amino acid substitutions along the mammalian phylogeny are irreversible, such that a return to the ancestral amino acid state would lead to a pathogenic phenotype. For a subset of 51 genes with high rates of irreversibility, as much as 40% of all amino acid evolution was estimated to be irreversible. Because pathogenic phenotypes do not resemble ancestral phenotypes, the molecular nature of the high rate of irreversibility in proteins is best explained by evolution with a high prevalence of compensatory, epistatic interactions between amino acid sites. Under such mode of protein evolution, once an amino acid substitution is fixed, the probability of its reversal declines as the protein sequence accumulates changes that affect the phenotypic manifestation of the ancestral state. The prevalence of epistasis in evolution indicates that the observed high rate of irreversibility in protein evolution is an inherent property of protein structure and function."}]},{"abstract":[{"lang":"eng","text":"The 1H dipolar network, which is the major obstacle for applying proton detection in the solid-state, can be reduced by deuteration, employing the RAP (Reduced Adjoining Protonation) labeling scheme, which yields random protonation at non-exchangeable sites. We present here a systematic study on the optimal degree of random sidechain protonation in RAP samples as a function of the MAS (magic angle spinning) frequency. In particular, we compare 1H sensitivity and linewidth of a microcrystalline protein, the SH3 domain of chicken α-spectrin, for samples, prepared with 5–25 % H2O in the E. coli growth medium, in the MAS frequency range of 20–60 kHz. At an external field of 19.96 T (850 MHz), we find that using a proton concentration between 15 and 25 % in the M9 medium yields the best compromise in terms of sensitivity and resolution, with an achievable average 1H linewidth on the order of 40–50 Hz. Comparing sensitivities at a MAS frequency of 60 versus 20 kHz, a gain in sensitivity by a factor of 4–4.5 is observed in INEPT-based 1H detected 1D 1H,13C correlation experiments. In total, we find that spectra recorded with a 1.3 mm rotor at 60 kHz have almost the same sensitivity as spectra recorded with a fully packed 3.2 mm rotor at 20 kHz, even though ~20× less material is employed. The improved sensitivity is attributed to 1H line narrowing due to fast MAS and to the increased efficiency of the 1.3 mm coil."}],"page":"155-168","status":"public","date_published":"2012-08-23T00:00:00Z","publication":"Journal of Biomolecular NMR","issue":"2","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":"        54","_id":"8463","language":[{"iso":"eng"}],"month":"08","oa_version":"None","author":[{"full_name":"Asami, Sam","last_name":"Asami","first_name":"Sam"},{"full_name":"Szekely, Kathrin","last_name":"Szekely","first_name":"Kathrin"},{"last_name":"Schanda","first_name":"Paul","id":"7B541462-FAF6-11E9-A490-E8DFE5697425","full_name":"Schanda, Paul","orcid":"0000-0002-9350-7606"},{"full_name":"Meier, Beat H.","last_name":"Meier","first_name":"Beat H."},{"full_name":"Reif, Bernd","first_name":"Bernd","last_name":"Reif"}],"article_type":"original","extern":"1","date_created":"2020-09-18T10:09:18Z","citation":{"ista":"Asami S, Szekely K, Schanda P, Meier BH, Reif B. 2012. Optimal degree of protonation for 1H detection of aliphatic sites in randomly deuterated proteins as a function of the MAS frequency. Journal of Biomolecular NMR. 54(2), 155–168.","apa":"Asami, S., Szekely, K., Schanda, P., Meier, B. H., &#38; Reif, B. (2012). Optimal degree of protonation for 1H detection of aliphatic sites in randomly deuterated proteins as a function of the MAS frequency. <i>Journal of Biomolecular NMR</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s10858-012-9659-9\">https://doi.org/10.1007/s10858-012-9659-9</a>","ama":"Asami S, Szekely K, Schanda P, Meier BH, Reif B. Optimal degree of protonation for 1H detection of aliphatic sites in randomly deuterated proteins as a function of the MAS frequency. <i>Journal of Biomolecular NMR</i>. 2012;54(2):155-168. doi:<a href=\"https://doi.org/10.1007/s10858-012-9659-9\">10.1007/s10858-012-9659-9</a>","mla":"Asami, Sam, et al. “Optimal Degree of Protonation for 1H Detection of Aliphatic Sites in Randomly Deuterated Proteins as a Function of the MAS Frequency.” <i>Journal of Biomolecular NMR</i>, vol. 54, no. 2, Springer Nature, 2012, pp. 155–68, doi:<a href=\"https://doi.org/10.1007/s10858-012-9659-9\">10.1007/s10858-012-9659-9</a>.","short":"S. Asami, K. Szekely, P. Schanda, B.H. Meier, B. Reif, Journal of Biomolecular NMR 54 (2012) 155–168.","chicago":"Asami, Sam, Kathrin Szekely, Paul Schanda, Beat H. Meier, and Bernd Reif. “Optimal Degree of Protonation for 1H Detection of Aliphatic Sites in Randomly Deuterated Proteins as a Function of the MAS Frequency.” <i>Journal of Biomolecular NMR</i>. Springer Nature, 2012. <a href=\"https://doi.org/10.1007/s10858-012-9659-9\">https://doi.org/10.1007/s10858-012-9659-9</a>.","ieee":"S. Asami, K. Szekely, P. Schanda, B. H. Meier, and B. Reif, “Optimal degree of protonation for 1H detection of aliphatic sites in randomly deuterated proteins as a function of the MAS frequency,” <i>Journal of Biomolecular NMR</i>, vol. 54, no. 2. Springer Nature, pp. 155–168, 2012."},"year":"2012","volume":54,"type":"journal_article","article_processing_charge":"No","title":"Optimal degree of protonation for 1H detection of aliphatic sites in randomly deuterated proteins as a function of the MAS frequency","doi":"10.1007/s10858-012-9659-9","quality_controlled":"1","publication_status":"published","publication_identifier":{"issn":["0925-2738","1573-5001"]},"day":"23","publisher":"Springer Nature","date_updated":"2021-01-12T08:19:27Z"},{"date_updated":"2021-01-12T08:19:27Z","publisher":"American Chemical Society","day":"21","publication_status":"published","publication_identifier":{"issn":["0002-7863","1520-5126"]},"quality_controlled":"1","doi":"10.1021/ja303591y","title":"Site-resolved measurement of microsecond-to-millisecond conformational-exchange processes in proteins by solid-state NMR spectroscopy","article_processing_charge":"No","type":"journal_article","volume":134,"year":"2012","date_created":"2020-09-18T10:10:20Z","citation":{"ista":"Tollinger M, Sivertsen AC, Meier BH, Ernst M, Schanda P. 2012. Site-resolved measurement of microsecond-to-millisecond conformational-exchange processes in proteins by solid-state NMR spectroscopy. Journal of the American Chemical Society. 134(36), 14800–14807.","apa":"Tollinger, M., Sivertsen, A. C., Meier, B. H., Ernst, M., &#38; Schanda, P. (2012). Site-resolved measurement of microsecond-to-millisecond conformational-exchange processes in proteins by solid-state NMR spectroscopy. <i>Journal of the American Chemical Society</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/ja303591y\">https://doi.org/10.1021/ja303591y</a>","ama":"Tollinger M, Sivertsen AC, Meier BH, Ernst M, Schanda P. Site-resolved measurement of microsecond-to-millisecond conformational-exchange processes in proteins by solid-state NMR spectroscopy. <i>Journal of the American Chemical Society</i>. 2012;134(36):14800-14807. doi:<a href=\"https://doi.org/10.1021/ja303591y\">10.1021/ja303591y</a>","short":"M. Tollinger, A.C. Sivertsen, B.H. Meier, M. Ernst, P. Schanda, Journal of the American Chemical Society 134 (2012) 14800–14807.","mla":"Tollinger, Martin, et al. “Site-Resolved Measurement of Microsecond-to-Millisecond Conformational-Exchange Processes in Proteins by Solid-State NMR Spectroscopy.” <i>Journal of the American Chemical Society</i>, vol. 134, no. 36, American Chemical Society, 2012, pp. 14800–07, doi:<a href=\"https://doi.org/10.1021/ja303591y\">10.1021/ja303591y</a>.","chicago":"Tollinger, Martin, Astrid C. Sivertsen, Beat H. Meier, Matthias Ernst, and Paul Schanda. “Site-Resolved Measurement of Microsecond-to-Millisecond Conformational-Exchange Processes in Proteins by Solid-State NMR Spectroscopy.” <i>Journal of the American Chemical Society</i>. American Chemical Society, 2012. <a href=\"https://doi.org/10.1021/ja303591y\">https://doi.org/10.1021/ja303591y</a>.","ieee":"M. Tollinger, A. C. Sivertsen, B. H. Meier, M. Ernst, and P. Schanda, “Site-resolved measurement of microsecond-to-millisecond conformational-exchange processes in proteins by solid-state NMR spectroscopy,” <i>Journal of the American Chemical Society</i>, vol. 134, no. 36. American Chemical Society, pp. 14800–14807, 2012."},"article_type":"original","extern":"1","author":[{"full_name":"Tollinger, Martin","first_name":"Martin","last_name":"Tollinger"},{"last_name":"Sivertsen","first_name":"Astrid C.","full_name":"Sivertsen, Astrid C."},{"full_name":"Meier, Beat H.","first_name":"Beat H.","last_name":"Meier"},{"full_name":"Ernst, Matthias","last_name":"Ernst","first_name":"Matthias"},{"orcid":"0000-0002-9350-7606","full_name":"Schanda, Paul","first_name":"Paul","last_name":"Schanda","id":"7B541462-FAF6-11E9-A490-E8DFE5697425"}],"oa_version":"None","month":"08","_id":"8465","intvolume":"       134","language":[{"iso":"eng"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","issue":"36","publication":"Journal of the American Chemical Society","date_published":"2012-08-21T00:00:00Z","status":"public","page":"14800-14807","abstract":[{"lang":"eng","text":"We demonstrate that conformational exchange processes in proteins on microsecond-to-millisecond time scales can be detected and quantified by solid-state NMR spectroscopy. We show two independent approaches that measure the effect of conformational exchange on transverse relaxation parameters, namely Carr–Purcell–Meiboom–Gill relaxation-dispersion experiments and measurement of differential multiple-quantum coherence decay. Long coherence lifetimes, as required for these experiments, are achieved by the use of highly deuterated samples and fast magic-angle spinning. The usefulness of the approaches is demonstrated by application to microcrystalline ubiquitin. We detect a conformational exchange process in a region of the protein for which dynamics have also been observed in solution. Interestingly, quantitative analysis of the data reveals that the exchange process is more than 1 order of magnitude slower than in solution, and this points to the impact of the crystalline environment on free energy barriers."}]},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"8466","intvolume":"       134","language":[{"iso":"eng"}],"abstract":[{"text":"Recent advances in NMR spectroscopy and the availability of high magnetic field strengths now offer the possibility to record real-time 3D NMR spectra of short-lived protein states, e.g., states that become transiently populated during protein folding. Here we present a strategy for obtaining sequential NMR assignments as well as atom-resolved information on structural and dynamic features within a folding intermediate of the amyloidogenic protein β2-microglobulin that has a half-lifetime of only 20 min.","lang":"eng"}],"page":"8066-8069","status":"public","date_published":"2012-05-03T00:00:00Z","issue":"19","publication":"Journal of the American Chemical Society","extern":"1","article_type":"original","citation":{"ista":"Rennella E, Cutuil T, Schanda P, Ayala I, Forge V, Brutscher B. 2012. Real-time NMR characterization of structure and dynamics in a transiently populated protein folding intermediate. Journal of the American Chemical Society. 134(19), 8066–8069.","apa":"Rennella, E., Cutuil, T., Schanda, P., Ayala, I., Forge, V., &#38; Brutscher, B. (2012). Real-time NMR characterization of structure and dynamics in a transiently populated protein folding intermediate. <i>Journal of the American Chemical Society</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/ja302598j\">https://doi.org/10.1021/ja302598j</a>","ama":"Rennella E, Cutuil T, Schanda P, Ayala I, Forge V, Brutscher B. Real-time NMR characterization of structure and dynamics in a transiently populated protein folding intermediate. <i>Journal of the American Chemical Society</i>. 2012;134(19):8066-8069. doi:<a href=\"https://doi.org/10.1021/ja302598j\">10.1021/ja302598j</a>","short":"E. Rennella, T. Cutuil, P. Schanda, I. Ayala, V. Forge, B. Brutscher, Journal of the American Chemical Society 134 (2012) 8066–8069.","mla":"Rennella, Enrico, et al. “Real-Time NMR Characterization of Structure and Dynamics in a Transiently Populated Protein Folding Intermediate.” <i>Journal of the American Chemical Society</i>, vol. 134, no. 19, American Chemical Society, 2012, pp. 8066–69, doi:<a href=\"https://doi.org/10.1021/ja302598j\">10.1021/ja302598j</a>.","chicago":"Rennella, Enrico, Thomas Cutuil, Paul Schanda, Isabel Ayala, Vincent Forge, and Bernhard Brutscher. “Real-Time NMR Characterization of Structure and Dynamics in a Transiently Populated Protein Folding Intermediate.” <i>Journal of the American Chemical Society</i>. American Chemical Society, 2012. <a href=\"https://doi.org/10.1021/ja302598j\">https://doi.org/10.1021/ja302598j</a>.","ieee":"E. Rennella, T. Cutuil, P. Schanda, I. Ayala, V. Forge, and B. Brutscher, “Real-time NMR characterization of structure and dynamics in a transiently populated protein folding intermediate,” <i>Journal of the American Chemical Society</i>, vol. 134, no. 19. American Chemical Society, pp. 8066–8069, 2012."},"date_created":"2020-09-18T10:10:28Z","month":"05","author":[{"last_name":"Rennella","first_name":"Enrico","full_name":"Rennella, Enrico"},{"first_name":"Thomas","last_name":"Cutuil","full_name":"Cutuil, Thomas"},{"last_name":"Schanda","first_name":"Paul","id":"7B541462-FAF6-11E9-A490-E8DFE5697425","orcid":"0000-0002-9350-7606","full_name":"Schanda, Paul"},{"first_name":"Isabel","last_name":"Ayala","full_name":"Ayala, Isabel"},{"full_name":"Forge, Vincent","first_name":"Vincent","last_name":"Forge"},{"last_name":"Brutscher","first_name":"Bernhard","full_name":"Brutscher, Bernhard"}],"oa_version":"None","volume":134,"type":"journal_article","article_processing_charge":"No","year":"2012","publication_status":"published","publication_identifier":{"issn":["0002-7863","1520-5126"]},"day":"03","publisher":"American Chemical Society","date_updated":"2021-01-12T08:19:28Z","title":"Real-time NMR characterization of structure and dynamics in a transiently populated protein folding intermediate","doi":"10.1021/ja302598j","quality_controlled":"1"},{"article_type":"original","extern":"1","citation":{"ama":"Huber M, With O, Schanda P, Verel R, Ernst M, Meier BH. A supplementary coil for 2H decoupling with commercial HCN MAS probes. <i>Journal of Magnetic Resonance</i>. 2012;214:76-80. doi:<a href=\"https://doi.org/10.1016/j.jmr.2011.10.010\">10.1016/j.jmr.2011.10.010</a>","ista":"Huber M, With O, Schanda P, Verel R, Ernst M, Meier BH. 2012. A supplementary coil for 2H decoupling with commercial HCN MAS probes. Journal of Magnetic Resonance. 214, 76–80.","apa":"Huber, M., With, O., Schanda, P., Verel, R., Ernst, M., &#38; Meier, B. H. (2012). A supplementary coil for 2H decoupling with commercial HCN MAS probes. <i>Journal of Magnetic Resonance</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.jmr.2011.10.010\">https://doi.org/10.1016/j.jmr.2011.10.010</a>","chicago":"Huber, Matthias, Oliver With, Paul Schanda, René Verel, Matthias Ernst, and Beat H. Meier. “A Supplementary Coil for 2H Decoupling with Commercial HCN MAS Probes.” <i>Journal of Magnetic Resonance</i>. Elsevier, 2012. <a href=\"https://doi.org/10.1016/j.jmr.2011.10.010\">https://doi.org/10.1016/j.jmr.2011.10.010</a>.","ieee":"M. Huber, O. With, P. Schanda, R. Verel, M. Ernst, and B. H. Meier, “A supplementary coil for 2H decoupling with commercial HCN MAS probes,” <i>Journal of Magnetic Resonance</i>, vol. 214. Elsevier, pp. 76–80, 2012.","mla":"Huber, Matthias, et al. “A Supplementary Coil for 2H Decoupling with Commercial HCN MAS Probes.” <i>Journal of Magnetic Resonance</i>, vol. 214, Elsevier, 2012, pp. 76–80, doi:<a href=\"https://doi.org/10.1016/j.jmr.2011.10.010\">10.1016/j.jmr.2011.10.010</a>.","short":"M. Huber, O. With, P. Schanda, R. Verel, M. Ernst, B.H. Meier, Journal of Magnetic Resonance 214 (2012) 76–80."},"date_created":"2020-09-18T10:10:36Z","oa_version":"None","author":[{"full_name":"Huber, Matthias","first_name":"Matthias","last_name":"Huber"},{"first_name":"Oliver","last_name":"With","full_name":"With, Oliver"},{"last_name":"Schanda","first_name":"Paul","id":"7B541462-FAF6-11E9-A490-E8DFE5697425","orcid":"0000-0002-9350-7606","full_name":"Schanda, Paul"},{"full_name":"Verel, René","last_name":"Verel","first_name":"René"},{"last_name":"Ernst","first_name":"Matthias","full_name":"Ernst, Matthias"},{"full_name":"Meier, Beat H.","last_name":"Meier","first_name":"Beat H."}],"month":"01","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"8467","language":[{"iso":"eng"}],"intvolume":"       214","page":"76-80","abstract":[{"lang":"eng","text":"Partial deuteration is a powerful tool to increase coherence life times and spectral resolution in proton solid-state NMR. The J coupling to deuterium needs, however, to be decoupled to maintain the good resolution in the (usually indirect) 13C dimension(s). We present a simple and reversible way to expand a commercial 1.3 mm HCN MAS probe with a 2H channel with sufficient field strength for J-decoupling of deuterium, namely 2–3 kHz. The coil is placed at the outside of the stator and requires no significant modifications to the probe. The performance and the realizable gains in sensitivity and resolution are demonstrated using perdeuterated ubiquitin, with selectively CHD2-labeled methyl groups."}],"publication":"Journal of Magnetic Resonance","date_published":"2012-01-01T00:00:00Z","status":"public","day":"01","publication_identifier":{"issn":["1090-7807"]},"publication_status":"published","date_updated":"2021-01-12T08:19:28Z","publisher":"Elsevier","doi":"10.1016/j.jmr.2011.10.010","title":"A supplementary coil for 2H decoupling with commercial HCN MAS probes","quality_controlled":"1","type":"journal_article","volume":214,"article_processing_charge":"No","year":"2012"},{"citation":{"ista":"Kaloshin V, Saprykina M. 2012. An example of a nearly integrable Hamiltonian system with a trajectory dense in a set of maximal Hausdorff dimension. Communications in Mathematical Physics. 315(3), 643–697.","apa":"Kaloshin, V., &#38; Saprykina, M. (2012). An example of a nearly integrable Hamiltonian system with a trajectory dense in a set of maximal Hausdorff dimension. <i>Communications in Mathematical Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s00220-012-1532-x\">https://doi.org/10.1007/s00220-012-1532-x</a>","ama":"Kaloshin V, Saprykina M. An example of a nearly integrable Hamiltonian system with a trajectory dense in a set of maximal Hausdorff dimension. <i>Communications in Mathematical Physics</i>. 2012;315(3):643-697. doi:<a href=\"https://doi.org/10.1007/s00220-012-1532-x\">10.1007/s00220-012-1532-x</a>","mla":"Kaloshin, Vadim, and Maria Saprykina. “An Example of a Nearly Integrable Hamiltonian System with a Trajectory Dense in a Set of Maximal Hausdorff Dimension.” <i>Communications in Mathematical Physics</i>, vol. 315, no. 3, Springer Nature, 2012, pp. 643–97, doi:<a href=\"https://doi.org/10.1007/s00220-012-1532-x\">10.1007/s00220-012-1532-x</a>.","short":"V. Kaloshin, M. Saprykina, Communications in Mathematical Physics 315 (2012) 643–697.","chicago":"Kaloshin, Vadim, and Maria Saprykina. “An Example of a Nearly Integrable Hamiltonian System with a Trajectory Dense in a Set of Maximal Hausdorff Dimension.” <i>Communications in Mathematical Physics</i>. Springer Nature, 2012. <a href=\"https://doi.org/10.1007/s00220-012-1532-x\">https://doi.org/10.1007/s00220-012-1532-x</a>.","ieee":"V. Kaloshin and M. Saprykina, “An example of a nearly integrable Hamiltonian system with a trajectory dense in a set of maximal Hausdorff dimension,” <i>Communications in Mathematical Physics</i>, vol. 315, no. 3. Springer Nature, pp. 643–697, 2012."},"keyword":["Mathematical Physics","Statistical and Nonlinear Physics"],"date_created":"2020-09-18T10:47:16Z","extern":"1","article_type":"original","oa_version":"None","author":[{"full_name":"Kaloshin, Vadim","orcid":"0000-0002-6051-2628","id":"FE553552-CDE8-11E9-B324-C0EBE5697425","first_name":"Vadim","last_name":"Kaloshin"},{"last_name":"Saprykina","first_name":"Maria","full_name":"Saprykina, Maria"}],"month":"11","_id":"8502","language":[{"iso":"eng"}],"intvolume":"       315","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","issue":"3","publication":"Communications in Mathematical Physics","date_published":"2012-11-01T00:00:00Z","status":"public","page":"643-697","abstract":[{"text":"The famous ergodic hypothesis suggests that for a typical Hamiltonian on a typical energy surface nearly all trajectories are dense. KAM theory disproves it. Ehrenfest (The Conceptual Foundations of the Statistical Approach in Mechanics. Ithaca, NY: Cornell University Press, 1959) and Birkhoff (Collected Math Papers. Vol 2, New York: Dover, pp 462–465, 1968) stated the quasi-ergodic hypothesis claiming that a typical Hamiltonian on a typical energy surface has a dense orbit. This question is wide open. Herman (Proceedings of the International Congress of Mathematicians, Vol II (Berlin, 1998). Doc Math 1998, Extra Vol II, Berlin: Int Math Union, pp 797–808, 1998) proposed to look for an example of a Hamiltonian near H0(I)=⟨I,I⟩2 with a dense orbit on the unit energy surface. In this paper we construct a Hamiltonian H0(I)+εH1(θ,I,ε) which has an orbit dense in a set of maximal Hausdorff dimension equal to 5 on the unit energy surface.","lang":"eng"}],"date_updated":"2021-01-12T08:19:44Z","publisher":"Springer Nature","day":"01","publication_identifier":{"issn":["0010-3616","1432-0916"]},"publication_status":"published","quality_controlled":"1","doi":"10.1007/s00220-012-1532-x","title":"An example of a nearly integrable Hamiltonian system with a trajectory dense in a set of maximal Hausdorff dimension","article_processing_charge":"No","type":"journal_article","volume":315,"year":"2012"},{"citation":{"ista":"Albouy A, Kaloshin V. 2012. Finiteness of central configurations of five bodies in the plane. Annals of Mathematics. 176(1), 535–588.","apa":"Albouy, A., &#38; Kaloshin, V. (2012). Finiteness of central configurations of five bodies in the plane. <i>Annals of Mathematics</i>. Princeton University Press. <a href=\"https://doi.org/10.4007/annals.2012.176.1.10\">https://doi.org/10.4007/annals.2012.176.1.10</a>","ama":"Albouy A, Kaloshin V. Finiteness of central configurations of five bodies in the plane. <i>Annals of Mathematics</i>. 2012;176(1):535-588. doi:<a href=\"https://doi.org/10.4007/annals.2012.176.1.10\">10.4007/annals.2012.176.1.10</a>","short":"A. Albouy, V. Kaloshin, Annals of Mathematics 176 (2012) 535–588.","mla":"Albouy, Alain, and Vadim Kaloshin. “Finiteness of Central Configurations of Five Bodies in the Plane.” <i>Annals of Mathematics</i>, vol. 176, no. 1, Princeton University Press, 2012, pp. 535–88, doi:<a href=\"https://doi.org/10.4007/annals.2012.176.1.10\">10.4007/annals.2012.176.1.10</a>.","chicago":"Albouy, Alain, and Vadim Kaloshin. “Finiteness of Central Configurations of Five Bodies in the Plane.” <i>Annals of Mathematics</i>. Princeton University Press, 2012. <a href=\"https://doi.org/10.4007/annals.2012.176.1.10\">https://doi.org/10.4007/annals.2012.176.1.10</a>.","ieee":"A. Albouy and V. Kaloshin, “Finiteness of central configurations of five bodies in the plane,” <i>Annals of Mathematics</i>, vol. 176, no. 1. Princeton University Press, pp. 535–588, 2012."},"date_created":"2020-09-18T10:47:24Z","article_type":"original","extern":"1","author":[{"first_name":"Alain","last_name":"Albouy","full_name":"Albouy, Alain"},{"orcid":"0000-0002-6051-2628","full_name":"Kaloshin, Vadim","id":"FE553552-CDE8-11E9-B324-C0EBE5697425","last_name":"Kaloshin","first_name":"Vadim"}],"oa_version":"None","month":"07","_id":"8503","intvolume":"       176","language":[{"iso":"eng"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication":"Annals of Mathematics","issue":"1","status":"public","date_published":"2012-07-01T00:00:00Z","page":"535-588","abstract":[{"text":"We prove there are finitely many isometry classes of planar central configurations (also called relative equilibria) in the Newtonian 5-body problem, except perhaps if the 5-tuple of positive masses belongs to a given codimension 2 subvariety of the mass space.","lang":"eng"}],"date_updated":"2021-01-12T08:19:44Z","publisher":"Princeton University Press","day":"01","publication_status":"published","publication_identifier":{"issn":["0003-486X"]},"quality_controlled":"1","doi":"10.4007/annals.2012.176.1.10","title":"Finiteness of central configurations of five bodies in the plane","article_processing_charge":"No","type":"journal_article","volume":176,"year":"2012"}]