[{"scopus_import":1,"abstract":[{"text":"Progress in understanding the global brain dynamics has remained slow to date in large part because of the highly multiscale nature of brain activity. Indeed, normal brain dynamics is characterized by complex interactions between multiple levels: from the microscopic scale of single neurons to the mesoscopic level of local groups of neurons, and finally to the macroscopic level of the whole brain. Among the most difficult tasks are those of identifying which scales are significant for a given particular function and describing how the scales affect each other. It is important to realize that the scales of time and space are linked together, or even intertwined, and that causal inference is far more ambiguous between than within levels. We approach this problem from the perspective of our recent work on simultaneous recording from micro- and macroelectrodes in the human brain. We propose a physiological description of these multilevel interactions, based on phase–amplitude coupling of neuronal oscillations that operate at multiple frequencies and on different spatial scales. Specifically, the amplitude of the oscillations on a particular spatial scale is modulated by phasic variations in neuronal excitability induced by lower frequency oscillations that emerge on a larger spatial scale. Following this general principle, it is possible to scale up or scale down the multiscale brain dynamics. It is expected that large-scale network oscillations in the low-frequency range, mediating downward effects, may play an important role in attention and consciousness.","lang":"eng"}],"quality_controlled":"1","editor":[{"full_name":"Meyer, Misha","last_name":"Meyer","first_name":"Misha"},{"first_name":"Z.","last_name":"Pesenson","full_name":"Pesenson, Z."}],"author":[{"full_name":"Valderrama, Mario","last_name":"Valderrama","first_name":"Mario"},{"first_name":"Vicente","orcid":"0000-0002-8790-1914","last_name":"Botella Soler","full_name":"Botella Soler, Vicente","id":"421234E8-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Le Van Quyen, Michel","last_name":"Le Van Quyen","first_name":"Michel"}],"date_published":"2013-08-01T00:00:00Z","alternative_title":["Reviews of Nonlinear Dynamics and Complexity"],"date_updated":"2021-01-12T06:57:20Z","doi":"10.1002/9783527671632.ch08","oa_version":"None","date_created":"2018-12-11T11:57:31Z","publist_id":"4513","title":"Neuronal oscillations scale up and scale down the brain dynamics ","department":[{"_id":"GaTk"}],"publication":"Multiscale Analysis and Nonlinear Dynamics: From Genes to the Brain","publisher":"Wiley-VCH","citation":{"ama":"Valderrama M, Botella Soler V, Le Van Quyen M. Neuronal oscillations scale up and scale down the brain dynamics . In: Meyer M, Pesenson Z, eds. <i>Multiscale Analysis and Nonlinear Dynamics: From Genes to the Brain</i>. Wiley-VCH; 2013. doi:<a href=\"https://doi.org/10.1002/9783527671632.ch08\">10.1002/9783527671632.ch08</a>","mla":"Valderrama, Mario, et al. “Neuronal Oscillations Scale up and Scale down the Brain Dynamics .” <i>Multiscale Analysis and Nonlinear Dynamics: From Genes to the Brain</i>, edited by Misha Meyer and Z. Pesenson, Wiley-VCH, 2013, doi:<a href=\"https://doi.org/10.1002/9783527671632.ch08\">10.1002/9783527671632.ch08</a>.","short":"M. Valderrama, V. Botella Soler, M. Le Van Quyen, in:, M. Meyer, Z. Pesenson (Eds.), Multiscale Analysis and Nonlinear Dynamics: From Genes to the Brain, Wiley-VCH, 2013.","ista":"Valderrama M, Botella Soler V, Le Van Quyen M. 2013.Neuronal oscillations scale up and scale down the brain dynamics . In: Multiscale Analysis and Nonlinear Dynamics: From Genes to the Brain. Reviews of Nonlinear Dynamics and Complexity, .","chicago":"Valderrama, Mario, Vicente Botella Soler, and Michel Le Van Quyen. “Neuronal Oscillations Scale up and Scale down the Brain Dynamics .” In <i>Multiscale Analysis and Nonlinear Dynamics: From Genes to the Brain</i>, edited by Misha Meyer and Z. Pesenson. Wiley-VCH, 2013. <a href=\"https://doi.org/10.1002/9783527671632.ch08\">https://doi.org/10.1002/9783527671632.ch08</a>.","ieee":"M. Valderrama, V. Botella Soler, and M. Le Van Quyen, “Neuronal oscillations scale up and scale down the brain dynamics ,” in <i>Multiscale Analysis and Nonlinear Dynamics: From Genes to the Brain</i>, M. Meyer and Z. Pesenson, Eds. Wiley-VCH, 2013.","apa":"Valderrama, M., Botella Soler, V., &#38; Le Van Quyen, M. (2013). Neuronal oscillations scale up and scale down the brain dynamics . In M. Meyer &#38; Z. Pesenson (Eds.), <i>Multiscale Analysis and Nonlinear Dynamics: From Genes to the Brain</i>. Wiley-VCH. <a href=\"https://doi.org/10.1002/9783527671632.ch08\">https://doi.org/10.1002/9783527671632.ch08</a>"},"language":[{"iso":"eng"}],"publication_identifier":{"eisbn":["9783527671632"],"isbn":["9783527411986 "]},"month":"08","status":"public","day":"01","_id":"2413","publication_status":"published","year":"2013","type":"book_chapter","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87"},{"intvolume":"         3","publication_status":"published","file":[{"date_updated":"2020-07-14T12:47:40Z","file_id":"6769","checksum":"83b7d429bc248c6c461229d3504fb139","file_name":"2013_IPOL_Mondelli.pdf","file_size":4306158,"access_level":"open_access","creator":"dernst","relation":"main_file","date_created":"2019-08-05T12:33:40Z","content_type":"application/pdf"}],"license":"https://creativecommons.org/licenses/by-nc-sa/4.0/","language":[{"iso":"eng"}],"month":"07","day":"11","ddc":["510"],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)","short":"CC BY-NC-SA (4.0)","image":"/images/cc_by_nc_sa.png"},"file_date_updated":"2020-07-14T12:47:40Z","quality_controlled":"1","date_published":"2013-07-11T00:00:00Z","author":[{"id":"27EB676C-8706-11E9-9510-7717E6697425","full_name":"Mondelli, Marco","orcid":"0000-0002-3242-7020","last_name":"Mondelli","first_name":"Marco"}],"doi":"10.5201/ipol.2013.53","date_updated":"2021-01-12T08:08:56Z","_id":"6768","has_accepted_license":"1","year":"2013","page":"68-111","volume":3,"type":"journal_article","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"chicago":"Mondelli, Marco. “A Finite Difference Scheme for the Stack Filter Simulating the MCM.” <i>Image Processing On Line</i>. Image Processing On Line, 2013. <a href=\"https://doi.org/10.5201/ipol.2013.53\">https://doi.org/10.5201/ipol.2013.53</a>.","ieee":"M. Mondelli, “A finite difference scheme for the stack filter simulating the MCM,” <i>Image Processing On Line</i>, vol. 3. Image Processing On Line, pp. 68–111, 2013.","apa":"Mondelli, M. (2013). A finite difference scheme for the stack filter simulating the MCM. <i>Image Processing On Line</i>. Image Processing On Line. <a href=\"https://doi.org/10.5201/ipol.2013.53\">https://doi.org/10.5201/ipol.2013.53</a>","ama":"Mondelli M. A finite difference scheme for the stack filter simulating the MCM. <i>Image Processing On Line</i>. 2013;3:68-111. doi:<a href=\"https://doi.org/10.5201/ipol.2013.53\">10.5201/ipol.2013.53</a>","ista":"Mondelli M. 2013. A finite difference scheme for the stack filter simulating the MCM. Image Processing On Line. 3, 68–111.","mla":"Mondelli, Marco. “A Finite Difference Scheme for the Stack Filter Simulating the MCM.” <i>Image Processing On Line</i>, vol. 3, Image Processing On Line, 2013, pp. 68–111, doi:<a href=\"https://doi.org/10.5201/ipol.2013.53\">10.5201/ipol.2013.53</a>.","short":"M. Mondelli, Image Processing On Line 3 (2013) 68–111."},"publication_identifier":{"issn":["2105-1232"]},"status":"public","oa":1,"article_type":"original","oa_version":"Published Version","date_created":"2019-08-05T12:30:38Z","title":"A finite difference scheme for the stack filter simulating the MCM","publication":"Image Processing On Line","publisher":"Image Processing On Line","abstract":[{"text":"The paper presents an algorithm that applies a stack filter simulating the Mean Curvature Motion equation via a finite difference scheme.","lang":"eng"}],"extern":"1"},{"status":"public","article_type":"original","day":"01","issue":"11","citation":{"short":"M.M. Ottakam Thotiyl, S.A. Freunberger, Z. Peng, Y. Chen, Z. Liu, P.G. Bruce, Nature Materials 12 (2013) 1050–1056.","ista":"Ottakam Thotiyl MM, Freunberger SA, Peng Z, Chen Y, Liu Z, Bruce PG. 2013. A stable cathode for the aprotic Li–O2 battery. Nature Materials. 12(11), 1050–1056.","mla":"Ottakam Thotiyl, Muhammed M., et al. “A Stable Cathode for the Aprotic Li–O2 Battery.” <i>Nature Materials</i>, vol. 12, no. 11, Springer Nature, 2013, pp. 1050–56, doi:<a href=\"https://doi.org/10.1038/nmat3737\">10.1038/nmat3737</a>.","ama":"Ottakam Thotiyl MM, Freunberger SA, Peng Z, Chen Y, Liu Z, Bruce PG. A stable cathode for the aprotic Li–O2 battery. <i>Nature Materials</i>. 2013;12(11):1050-1056. doi:<a href=\"https://doi.org/10.1038/nmat3737\">10.1038/nmat3737</a>","apa":"Ottakam Thotiyl, M. M., Freunberger, S. A., Peng, Z., Chen, Y., Liu, Z., &#38; Bruce, P. G. (2013). A stable cathode for the aprotic Li–O2 battery. <i>Nature Materials</i>. Springer Nature. <a href=\"https://doi.org/10.1038/nmat3737\">https://doi.org/10.1038/nmat3737</a>","ieee":"M. M. Ottakam Thotiyl, S. A. Freunberger, Z. Peng, Y. Chen, Z. Liu, and P. G. Bruce, “A stable cathode for the aprotic Li–O2 battery,” <i>Nature Materials</i>, vol. 12, no. 11. Springer Nature, pp. 1050–1056, 2013.","chicago":"Ottakam Thotiyl, Muhammed M., Stefan Alexander Freunberger, Zhangquan Peng, Yuhui Chen, Zheng Liu, and Peter G. Bruce. “A Stable Cathode for the Aprotic Li–O2 Battery.” <i>Nature Materials</i>. Springer Nature, 2013. <a href=\"https://doi.org/10.1038/nmat3737\">https://doi.org/10.1038/nmat3737</a>."},"language":[{"iso":"eng"}],"publication_identifier":{"issn":["1476-1122","1476-4660"]},"month":"09","page":"1050-1056","volume":12,"type":"journal_article","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"7306","intvolume":"        12","publication_status":"published","year":"2013","author":[{"full_name":"Ottakam Thotiyl, Muhammed M.","first_name":"Muhammed M.","last_name":"Ottakam Thotiyl"},{"full_name":"Freunberger, Stefan Alexander","id":"A8CA28E6-CE23-11E9-AD2D-EC27E6697425","first_name":"Stefan Alexander","orcid":"0000-0003-2902-5319","last_name":"Freunberger"},{"last_name":"Peng","first_name":"Zhangquan","full_name":"Peng, Zhangquan"},{"full_name":"Chen, Yuhui","first_name":"Yuhui","last_name":"Chen"},{"full_name":"Liu, Zheng","last_name":"Liu","first_name":"Zheng"},{"last_name":"Bruce","first_name":"Peter G.","full_name":"Bruce, Peter G."}],"date_published":"2013-09-01T00:00:00Z","doi":"10.1038/nmat3737","date_updated":"2021-01-12T08:12:55Z","article_processing_charge":"No","abstract":[{"lang":"eng","text":"Rechargeable lithium–air (O2) batteries are receiving intense interest because their high theoretical specific energy exceeds that of lithium-ion batteries. If the Li–O2 battery is ever to succeed, highly reversible formation/decomposition of Li2O2 must take place at the cathode on cycling. However, carbon, used ubiquitously as the basis of the cathode, decomposes during Li2O2 oxidation on charge and actively promotes electrolyte decomposition on cycling. Replacing carbon with a nanoporous gold cathode, when in contact with a dimethyl sulphoxide-based electrolyte, does seem to demonstrate better stability. However, nanoporous gold is not a suitable cathode; its high mass destroys the key advantage of Li–O2 over Li ion (specific energy), it is too expensive and too difficult to fabricate. Identifying a suitable cathode material for the Li–O2 cell is one of the greatest challenges at present. Here we show that a TiC-based cathode reduces greatly side reactions (arising from the electrolyte and electrode degradation) compared with carbon and exhibits better reversible formation/decomposition of Li2O2 even than nanoporous gold (>98% capacity retention after 100 cycles, compared with 95% for nanoporous gold); it is also four times lighter, of lower cost and easier to fabricate. The stability may originate from the presence of TiO2 (along with some TiOC) on the surface of TiC. In contrast to carbon or nanoporous gold, TiC seems to represent a more viable, stable, cathode for aprotic Li–O2 cells."}],"quality_controlled":"1","extern":"1","title":"A stable cathode for the aprotic Li–O2 battery","publication":"Nature Materials","publisher":"Springer Nature","oa_version":"None","date_created":"2020-01-15T12:18:29Z"},{"extern":"1","quality_controlled":"1","abstract":[{"text":"The non-aqueous Li–air (O2) battery is receiving intense interest because its theoretical specific energy exceeds that of Li-ion batteries. Recharging the Li–O2 battery depends on oxidizing solid lithium peroxide (Li2O2), which is formed on discharge within the porous cathode. However, transporting charge between Li2O2 particles and the solid electrode surface is at best very difficult and leads to voltage polarization on charging, even at modest rates. This is a significant problem facing the non-aqueous Li–O2 battery. Here we show that incorporation of a redox mediator, tetrathiafulvalene (TTF), enables recharging at rates that are impossible for the cell in the absence of the mediator. On charging, TTF is oxidized to TTF+ at the cathode surface; TTF+ in turn oxidizes the solid Li2O2, which results in the regeneration of TTF. The mediator acts as an electron–hole transfer agent that permits efficient oxidation of solid Li2O2. The cell with the mediator demonstrated 100 charge/discharge cycles.","lang":"eng"}],"doi":"10.1038/nchem.1646","date_updated":"2021-01-12T08:12:56Z","article_processing_charge":"No","author":[{"full_name":"Chen, Yuhui","first_name":"Yuhui","last_name":"Chen"},{"orcid":"0000-0003-2902-5319","last_name":"Freunberger","first_name":"Stefan Alexander","id":"A8CA28E6-CE23-11E9-AD2D-EC27E6697425","full_name":"Freunberger, Stefan Alexander"},{"full_name":"Peng, Zhangquan","last_name":"Peng","first_name":"Zhangquan"},{"full_name":"Fontaine, Olivier","first_name":"Olivier","last_name":"Fontaine"},{"full_name":"Bruce, Peter G.","last_name":"Bruce","first_name":"Peter G."}],"date_published":"2013-05-12T00:00:00Z","oa_version":"None","date_created":"2020-01-15T12:18:43Z","publisher":"Springer Nature","title":"Charging a Li–O2 battery using a redox mediator","publication":"Nature Chemistry","publication_identifier":{"issn":["1755-4330","1755-4349"]},"language":[{"iso":"eng"}],"month":"05","citation":{"apa":"Chen, Y., Freunberger, S. A., Peng, Z., Fontaine, O., &#38; Bruce, P. G. (2013). Charging a Li–O2 battery using a redox mediator. <i>Nature Chemistry</i>. Springer Nature. <a href=\"https://doi.org/10.1038/nchem.1646\">https://doi.org/10.1038/nchem.1646</a>","chicago":"Chen, Yuhui, Stefan Alexander Freunberger, Zhangquan Peng, Olivier Fontaine, and Peter G. Bruce. “Charging a Li–O2 Battery Using a Redox Mediator.” <i>Nature Chemistry</i>. Springer Nature, 2013. <a href=\"https://doi.org/10.1038/nchem.1646\">https://doi.org/10.1038/nchem.1646</a>.","ieee":"Y. Chen, S. A. Freunberger, Z. Peng, O. Fontaine, and P. G. Bruce, “Charging a Li–O2 battery using a redox mediator,” <i>Nature Chemistry</i>, vol. 5, no. 6. Springer Nature, pp. 489–494, 2013.","mla":"Chen, Yuhui, et al. “Charging a Li–O2 Battery Using a Redox Mediator.” <i>Nature Chemistry</i>, vol. 5, no. 6, Springer Nature, 2013, pp. 489–94, doi:<a href=\"https://doi.org/10.1038/nchem.1646\">10.1038/nchem.1646</a>.","short":"Y. Chen, S.A. Freunberger, Z. Peng, O. Fontaine, P.G. Bruce, Nature Chemistry 5 (2013) 489–494.","ista":"Chen Y, Freunberger SA, Peng Z, Fontaine O, Bruce PG. 2013. Charging a Li–O2 battery using a redox mediator. Nature Chemistry. 5(6), 489–494.","ama":"Chen Y, Freunberger SA, Peng Z, Fontaine O, Bruce PG. Charging a Li–O2 battery using a redox mediator. <i>Nature Chemistry</i>. 2013;5(6):489-494. doi:<a href=\"https://doi.org/10.1038/nchem.1646\">10.1038/nchem.1646</a>"},"day":"12","article_type":"original","issue":"6","status":"public","publication_status":"published","year":"2013","intvolume":"         5","_id":"7307","type":"journal_article","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","page":"489-494","volume":5},{"author":[{"last_name":"Tang","first_name":"Yong","full_name":"Tang, Yong"},{"orcid":"0000-0002-0471-8285","last_name":"Tan","first_name":"Shutang","id":"2DE75584-F248-11E8-B48F-1D18A9856A87","full_name":"Tan, Shutang"},{"full_name":"Xue, Hongwei","first_name":"Hongwei","last_name":"Xue"}],"date_published":"2013-07-01T00:00:00Z","doi":"10.1093/abbs/gmt039","date_updated":"2021-01-12T08:14:23Z","article_processing_charge":"No","quality_controlled":"1","pmid":1,"day":"01","language":[{"iso":"eng"}],"month":"07","intvolume":"        45","publication_status":"published","abstract":[{"text":"Inositol 1,3,4-trisphosphate 5/6 kinase (ITPK) phosphorylates inositol 1,3,4-trisphosphate to form inositol 1,3,4,5-tetrakisphosphate and inositol 1,3,4,6-tetrakisphosphate which can be finally transferred to inositol hexaphosphate (IP6) and play important roles during plant growth and development. There are 4 putative ITPK members in Arabidopsis. Expression pattern analysis showed that ITPK2 is constitutively expressed in various tissues. A T-DNA knockout mutant of ITPK2 was identified and scanning electron microscopy (SEM) analysis showed that the epidermis structure of seed coat was irregularly formed in seeds of itpk2-1 mutant, resulting in the increased permeability of seed coat to tetrazolium salts. Further analysis by gas chromatography coupled with mass spectrometry of lipid polyester monomers in cell wall confirmed a dramatic decrease in composition of suberin and cutin, which relate to the permeability of seed coat and the formation of which is accompanied with seed coat development. These results indicate that ITPK2 plays an essential role in seed coat development and lipid polyester barrier formation.","lang":"eng"}],"extern":"1","title":"Arabidopsis inositol 1,3,4-trisphosphate 5/6 kinase 2 is required for seed coat development","publication":"Acta Biochimica et Biophysica Sinica","publisher":"Oxford University Press","oa_version":"None","date_created":"2020-03-21T16:06:36Z","status":"public","article_type":"original","external_id":{"pmid":["23595027"]},"issue":"7","citation":{"ieee":"Y. Tang, S. Tan, and H. Xue, “Arabidopsis inositol 1,3,4-trisphosphate 5/6 kinase 2 is required for seed coat development,” <i>Acta Biochimica et Biophysica Sinica</i>, vol. 45, no. 7. Oxford University Press, pp. 549–560, 2013.","chicago":"Tang, Yong, Shutang Tan, and Hongwei Xue. “Arabidopsis Inositol 1,3,4-Trisphosphate 5/6 Kinase 2 Is Required for Seed Coat Development.” <i>Acta Biochimica et Biophysica Sinica</i>. Oxford University Press, 2013. <a href=\"https://doi.org/10.1093/abbs/gmt039\">https://doi.org/10.1093/abbs/gmt039</a>.","apa":"Tang, Y., Tan, S., &#38; Xue, H. (2013). Arabidopsis inositol 1,3,4-trisphosphate 5/6 kinase 2 is required for seed coat development. <i>Acta Biochimica et Biophysica Sinica</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/abbs/gmt039\">https://doi.org/10.1093/abbs/gmt039</a>","ama":"Tang Y, Tan S, Xue H. Arabidopsis inositol 1,3,4-trisphosphate 5/6 kinase 2 is required for seed coat development. <i>Acta Biochimica et Biophysica Sinica</i>. 2013;45(7):549-560. doi:<a href=\"https://doi.org/10.1093/abbs/gmt039\">10.1093/abbs/gmt039</a>","ista":"Tang Y, Tan S, Xue H. 2013. Arabidopsis inositol 1,3,4-trisphosphate 5/6 kinase 2 is required for seed coat development. Acta Biochimica et Biophysica Sinica. 45(7), 549–560.","short":"Y. Tang, S. Tan, H. Xue, Acta Biochimica et Biophysica Sinica 45 (2013) 549–560.","mla":"Tang, Yong, et al. “Arabidopsis Inositol 1,3,4-Trisphosphate 5/6 Kinase 2 Is Required for Seed Coat Development.” <i>Acta Biochimica et Biophysica Sinica</i>, vol. 45, no. 7, Oxford University Press, 2013, pp. 549–60, doi:<a href=\"https://doi.org/10.1093/abbs/gmt039\">10.1093/abbs/gmt039</a>."},"publication_identifier":{"issn":["1745-7270","1672-9145"]},"page":"549-560","volume":45,"type":"journal_article","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"7595","year":"2013"},{"date_updated":"2021-01-12T08:14:24Z","doi":"10.1105/tpc.113.114322","article_processing_charge":"No","author":[{"first_name":"Shutang","orcid":"0000-0002-0471-8285","last_name":"Tan","full_name":"Tan, Shutang","id":"2DE75584-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Dai","first_name":"C.","full_name":"Dai, C."},{"first_name":"H.-T.","last_name":"Liu","full_name":"Liu, H.-T."},{"full_name":"Xue, H.-W.","last_name":"Xue","first_name":"H.-W."}],"date_published":"2013-08-26T00:00:00Z","quality_controlled":"1","publication_status":"published","intvolume":"        25","day":"26","pmid":1,"language":[{"iso":"eng"}],"month":"08","publisher":"American Society of Plant Biologists","title":"Arabidopsis casein kinase1 proteins CK1.3 and CK1.4 phosphorylate cryptochrome2 to regulate blue light signaling","publication":"The Plant Cell","oa_version":"None","date_created":"2020-03-21T16:06:55Z","extern":"1","abstract":[{"text":"Casein kinase1 (CK1) plays crucial roles in regulating growth and development via phosphorylating various substrates throughout the eukaryote kingdom. Blue light is crucial for normal growth of both plants and animals, and blue light receptor cryptochrome2 (CRY2) undergoes blue light–dependent phosphorylation and degradation in planta. To study the function of plant CK1s, systematic genetic analysis showed that deficiency of two paralogous Arabidopsis thaliana CK1s, CK1.3 and CK1.4, caused shortened hypocotyls, especially under blue light, while overexpression of either CK1.3 or CK1.4 resulted in the insensitive response to blue light and delayed flowering under long-day conditions. CK1.3 or CK1.4 act dependently on CRY2, and overexpression of CK1.3 or CK1.4 significantly suppresses the hypersensitive response to blue light by CRY2 overexpression. Biochemical studies showed that CK1.3 and CK1.4 directly phosphorylate CRY2 at Ser-587 and Thr-603 in vitro and negatively regulate CRY2 stability in planta, which are stimulated by blue light, further confirming the crucial roles of CK1.3 and CK1.4 in blue light responses through phosphorylating CRY2. Interestingly, expression of CK1.3 and CK1.4 is stimulated by blue light and feedback regulated by CRY2-mediated signaling. These results provide direct evidence for CRY2 phosphorylation and informative clues on the mechanisms of CRY2-mediated light responses.","lang":"eng"}],"type":"journal_article","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","page":"2618-2632","volume":25,"year":"2013","_id":"7596","external_id":{"pmid":["23897926"]},"article_type":"original","issue":"7","status":"public","publication_identifier":{"issn":["1040-4651","1532-298X"]},"citation":{"ama":"Tan S, Dai C, Liu H-T, Xue H-W. Arabidopsis casein kinase1 proteins CK1.3 and CK1.4 phosphorylate cryptochrome2 to regulate blue light signaling. <i>The Plant Cell</i>. 2013;25(7):2618-2632. doi:<a href=\"https://doi.org/10.1105/tpc.113.114322\">10.1105/tpc.113.114322</a>","ista":"Tan S, Dai C, Liu H-T, Xue H-W. 2013. Arabidopsis casein kinase1 proteins CK1.3 and CK1.4 phosphorylate cryptochrome2 to regulate blue light signaling. The Plant Cell. 25(7), 2618–2632.","mla":"Tan, Shutang, et al. “Arabidopsis Casein Kinase1 Proteins CK1.3 and CK1.4 Phosphorylate Cryptochrome2 to Regulate Blue Light Signaling.” <i>The Plant Cell</i>, vol. 25, no. 7, American Society of Plant Biologists, 2013, pp. 2618–32, doi:<a href=\"https://doi.org/10.1105/tpc.113.114322\">10.1105/tpc.113.114322</a>.","short":"S. Tan, C. Dai, H.-T. Liu, H.-W. Xue, The Plant Cell 25 (2013) 2618–2632.","chicago":"Tan, Shutang, C. Dai, H.-T. Liu, and H.-W. Xue. “Arabidopsis Casein Kinase1 Proteins CK1.3 and CK1.4 Phosphorylate Cryptochrome2 to Regulate Blue Light Signaling.” <i>The Plant Cell</i>. American Society of Plant Biologists, 2013. <a href=\"https://doi.org/10.1105/tpc.113.114322\">https://doi.org/10.1105/tpc.113.114322</a>.","ieee":"S. Tan, C. Dai, H.-T. Liu, and H.-W. Xue, “Arabidopsis casein kinase1 proteins CK1.3 and CK1.4 phosphorylate cryptochrome2 to regulate blue light signaling,” <i>The Plant Cell</i>, vol. 25, no. 7. American Society of Plant Biologists, pp. 2618–2632, 2013.","apa":"Tan, S., Dai, C., Liu, H.-T., &#38; Xue, H.-W. (2013). Arabidopsis casein kinase1 proteins CK1.3 and CK1.4 phosphorylate cryptochrome2 to regulate blue light signaling. <i>The Plant Cell</i>. American Society of Plant Biologists. <a href=\"https://doi.org/10.1105/tpc.113.114322\">https://doi.org/10.1105/tpc.113.114322</a>"}},{"page":"200 - 209","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"conference","_id":"765","year":"2013","publication_status":"published","acknowledgement":"Dan Alistarh - This author was supported by the SNF Postdoctoral Fellows Program, NSF grant CCF-1217921, DoE ASCR grant\r\nER26116/DE-SC0008923,  and  by  grants  from  the  Oracle\r\nand Intel corporations.\r\nJames Aspnes - Supported in part by NSF grant CCF-0916389.\r\nGeorge Giakkoupis - This work was funded in part by INRIA Associate Team\r\nRADCON, and ERC Starting Grant GOSSPLE 204742.\r\nPhilipp Woelfel - This research was undertaken, in part, thanks to funding\r\nfrom the Canada Research Chairs program and the HP Labs\r\nInnovation Research Program.","status":"public","day":"01","citation":{"ama":"Alistarh D-A, Aspnes J, Giakkoupis G, Woelfel P. Randomized loose renaming in O(loglogn) time. In: ACM; 2013:200-209. doi:<a href=\"https://doi.org/10.1145/2484239.2484240\">10.1145/2484239.2484240</a>","ista":"Alistarh D-A, Aspnes J, Giakkoupis G, Woelfel P. 2013. Randomized loose renaming in O(loglogn) time. PODC: Principles of Distributed Computing, 200–209.","mla":"Alistarh, Dan-Adrian, et al. <i>Randomized Loose Renaming in O(Loglogn) Time</i>. ACM, 2013, pp. 200–09, doi:<a href=\"https://doi.org/10.1145/2484239.2484240\">10.1145/2484239.2484240</a>.","short":"D.-A. Alistarh, J. Aspnes, G. Giakkoupis, P. Woelfel, in:, ACM, 2013, pp. 200–209.","ieee":"D.-A. Alistarh, J. Aspnes, G. Giakkoupis, and P. Woelfel, “Randomized loose renaming in O(loglogn) time,” presented at the PODC: Principles of Distributed Computing, 2013, pp. 200–209.","chicago":"Alistarh, Dan-Adrian, James Aspnes, George Giakkoupis, and Philipp Woelfel. “Randomized Loose Renaming in O(Loglogn) Time,” 200–209. ACM, 2013. <a href=\"https://doi.org/10.1145/2484239.2484240\">https://doi.org/10.1145/2484239.2484240</a>.","apa":"Alistarh, D.-A., Aspnes, J., Giakkoupis, G., &#38; Woelfel, P. (2013). Randomized loose renaming in O(loglogn) time (pp. 200–209). Presented at the PODC: Principles of Distributed Computing, ACM. <a href=\"https://doi.org/10.1145/2484239.2484240\">https://doi.org/10.1145/2484239.2484240</a>"},"month":"01","language":[{"iso":"eng"}],"title":"Randomized loose renaming in O(loglogn) time","publisher":"ACM","date_created":"2018-12-11T11:48:23Z","conference":{"name":"PODC: Principles of Distributed Computing"},"oa_version":"None","publist_id":"6889","author":[{"orcid":"0000-0003-3650-940X","last_name":"Alistarh","first_name":"Dan-Adrian","id":"4A899BFC-F248-11E8-B48F-1D18A9856A87","full_name":"Alistarh, Dan-Adrian"},{"last_name":"Aspnes","first_name":"James","full_name":"Aspnes, James"},{"first_name":"George","last_name":"Giakkoupis","full_name":"Giakkoupis, George"},{"last_name":"Woelfel","first_name":"Philipp","full_name":"Woelfel, Philipp"}],"date_published":"2013-01-01T00:00:00Z","article_processing_charge":"No","date_updated":"2023-02-23T13:13:14Z","doi":"10.1145/2484239.2484240","abstract":[{"text":"Renaming is a classic distributed coordination task in which a set of processes must pick distinct identifiers from a small namespace. In this paper, we consider the time complexity of this problem when the namespace is linear in the number of participants, a variant known as loose renaming. We give a non-adaptive algorithm with O(log log n) (individual) step complexity, where n is a known upper bound on contention, and an adaptive algorithm with step complexity O((log log k)2), where k is the actual contention in the execution. We also present a variant of the adaptive algorithm which requires O(k log log k) total process steps. All upper bounds hold with high probability against a strong adaptive adversary. We complement the algorithms with an ω(log log n) expected time lower bound on the complexity of randomized renaming using test-and-set operations and linear space. The result is based on a new coupling technique, and is the first to apply to non-adaptive randomized renaming. Since our algorithms use O(n) test-and-set objects, our results provide matching bounds on the cost of loose renaming in this setting.","lang":"eng"}],"extern":"1"},{"citation":{"ama":"Robinson MR, Santure AW, DeCauwer I, Sheldon BC, Slate J. Partitioning of genetic variation across the genome using multimarker methods in a wild bird population. <i>Molecular Ecology</i>. 2013;22(15):3963-3980. doi:<a href=\"https://doi.org/10.1111/mec.12375\">10.1111/mec.12375</a>","mla":"Robinson, Matthew Richard, et al. “Partitioning of Genetic Variation across the Genome Using Multimarker Methods in a Wild Bird Population.” <i>Molecular Ecology</i>, vol. 22, no. 15, Wiley, 2013, pp. 3963–80, doi:<a href=\"https://doi.org/10.1111/mec.12375\">10.1111/mec.12375</a>.","ista":"Robinson MR, Santure AW, DeCauwer I, Sheldon BC, Slate J. 2013. Partitioning of genetic variation across the genome using multimarker methods in a wild bird population. Molecular Ecology. 22(15), 3963–3980.","short":"M.R. Robinson, A.W. Santure, I. DeCauwer, B.C. Sheldon, J. Slate, Molecular Ecology 22 (2013) 3963–3980.","ieee":"M. R. Robinson, A. W. Santure, I. DeCauwer, B. C. Sheldon, and J. Slate, “Partitioning of genetic variation across the genome using multimarker methods in a wild bird population,” <i>Molecular Ecology</i>, vol. 22, no. 15. Wiley, pp. 3963–3980, 2013.","chicago":"Robinson, Matthew Richard, Anna W. Santure, Isabelle DeCauwer, Ben C. Sheldon, and Jon Slate. “Partitioning of Genetic Variation across the Genome Using Multimarker Methods in a Wild Bird Population.” <i>Molecular Ecology</i>. Wiley, 2013. <a href=\"https://doi.org/10.1111/mec.12375\">https://doi.org/10.1111/mec.12375</a>.","apa":"Robinson, M. R., Santure, A. W., DeCauwer, I., Sheldon, B. C., &#38; Slate, J. (2013). Partitioning of genetic variation across the genome using multimarker methods in a wild bird population. <i>Molecular Ecology</i>. Wiley. <a href=\"https://doi.org/10.1111/mec.12375\">https://doi.org/10.1111/mec.12375</a>"},"publication_identifier":{"issn":["0962-1083"]},"language":[{"iso":"eng"}],"month":"08","status":"public","day":"01","article_type":"original","issue":"15","_id":"7745","intvolume":"        22","publication_status":"published","year":"2013","page":"3963-3980","volume":22,"type":"journal_article","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","abstract":[{"lang":"eng","text":"The underlying basis of genetic variation in quantitative traits, in terms of the number of causal variants and the size of their effects, is largely unknown in natural populations. The expectation is that complex quantitative trait variation is attributable to many, possibly interacting, causal variants, whose effects may depend upon the sex, age and the environment in which they are expressed. A recently developed methodology in animal breeding derives a value of relatedness among individuals from high‐density genomic marker data, to estimate additive genetic variance within livestock populations. Here, we adapt and test the effectiveness of these methods to partition genetic variation for complex traits across genomic regions within ecological study populations where individuals have varying degrees of relatedness. We then apply this approach for the first time to a natural population and demonstrate that genetic variation in wing length in the great tit (Parus major) reflects contributions from multiple genomic regions. We show that a polygenic additive mode of gene action best describes the patterns observed, and we find no evidence of dosage compensation for the sex chromosome. Our results suggest that most of the genomic regions that influence wing length have the same effects in both sexes. We found a limited amount of genetic variance in males that is attributed to regions that have no effects in females, which could facilitate the sexual dimorphism observed for this trait. Although this exploratory work focuses on one complex trait, the methodology is generally applicable to any trait for any laboratory or wild population, paving the way for investigating sex‐, age‐ and environment‐specific genetic effects and thus the underlying genetic architecture of phenotype in biological study systems."}],"extern":"1","quality_controlled":"1","author":[{"first_name":"Matthew Richard","last_name":"Robinson","orcid":"0000-0001-8982-8813","full_name":"Robinson, Matthew Richard","id":"E5D42276-F5DA-11E9-8E24-6303E6697425"},{"full_name":"Santure, Anna W.","first_name":"Anna W.","last_name":"Santure"},{"last_name":"DeCauwer","first_name":"Isabelle","full_name":"DeCauwer, Isabelle"},{"full_name":"Sheldon, Ben C.","first_name":"Ben C.","last_name":"Sheldon"},{"first_name":"Jon","last_name":"Slate","full_name":"Slate, Jon"}],"date_published":"2013-08-01T00:00:00Z","doi":"10.1111/mec.12375","date_updated":"2021-01-12T08:15:14Z","article_processing_charge":"No","oa_version":"None","date_created":"2020-04-30T11:00:15Z","title":"Partitioning of genetic variation across the genome using multimarker methods in a wild bird population","publication":"Molecular Ecology","publisher":"Wiley"},{"page":"3949-3962","volume":22,"type":"journal_article","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":"        22","_id":"7746","publication_status":"published","year":"2013","status":"public","article_type":"original","day":"01","issue":"15","citation":{"ieee":"A. W. Santure, I. De Cauwer, M. R. Robinson, J. Poissant, B. C. Sheldon, and J. Slate, “Genomic dissection of variation in clutch size and egg mass in a wild great tit (Parus major) population,” <i>Molecular Ecology</i>, vol. 22, no. 15. Wiley, pp. 3949–3962, 2013.","chicago":"Santure, Anna W., Isabelle De Cauwer, Matthew Richard Robinson, Jocelyn Poissant, Ben C. Sheldon, and Jon Slate. “Genomic Dissection of Variation in Clutch Size and Egg Mass in a Wild Great Tit (Parus Major) Population.” <i>Molecular Ecology</i>. Wiley, 2013. <a href=\"https://doi.org/10.1111/mec.12376\">https://doi.org/10.1111/mec.12376</a>.","apa":"Santure, A. W., De Cauwer, I., Robinson, M. R., Poissant, J., Sheldon, B. C., &#38; Slate, J. (2013). Genomic dissection of variation in clutch size and egg mass in a wild great tit (Parus major) population. <i>Molecular Ecology</i>. Wiley. <a href=\"https://doi.org/10.1111/mec.12376\">https://doi.org/10.1111/mec.12376</a>","ama":"Santure AW, De Cauwer I, Robinson MR, Poissant J, Sheldon BC, Slate J. Genomic dissection of variation in clutch size and egg mass in a wild great tit (Parus major) population. <i>Molecular Ecology</i>. 2013;22(15):3949-3962. doi:<a href=\"https://doi.org/10.1111/mec.12376\">10.1111/mec.12376</a>","mla":"Santure, Anna W., et al. “Genomic Dissection of Variation in Clutch Size and Egg Mass in a Wild Great Tit (Parus Major) Population.” <i>Molecular Ecology</i>, vol. 22, no. 15, Wiley, 2013, pp. 3949–62, doi:<a href=\"https://doi.org/10.1111/mec.12376\">10.1111/mec.12376</a>.","ista":"Santure AW, De Cauwer I, Robinson MR, Poissant J, Sheldon BC, Slate J. 2013. Genomic dissection of variation in clutch size and egg mass in a wild great tit (Parus major) population. Molecular Ecology. 22(15), 3949–3962.","short":"A.W. Santure, I. De Cauwer, M.R. Robinson, J. Poissant, B.C. Sheldon, J. Slate, Molecular Ecology 22 (2013) 3949–3962."},"publication_identifier":{"issn":["0962-1083"]},"language":[{"iso":"eng"}],"month":"08","title":"Genomic dissection of variation in clutch size and egg mass in a wild great tit (Parus major) population","publication":"Molecular Ecology","publisher":"Wiley","oa_version":"None","date_created":"2020-04-30T11:00:32Z","date_published":"2013-08-01T00:00:00Z","author":[{"full_name":"Santure, Anna W.","first_name":"Anna W.","last_name":"Santure"},{"full_name":"De Cauwer, Isabelle","first_name":"Isabelle","last_name":"De Cauwer"},{"full_name":"Robinson, Matthew Richard","id":"E5D42276-F5DA-11E9-8E24-6303E6697425","first_name":"Matthew Richard","last_name":"Robinson","orcid":"0000-0001-8982-8813"},{"first_name":"Jocelyn","last_name":"Poissant","full_name":"Poissant, Jocelyn"},{"first_name":"Ben C.","last_name":"Sheldon","full_name":"Sheldon, Ben C."},{"first_name":"Jon","last_name":"Slate","full_name":"Slate, Jon"}],"doi":"10.1111/mec.12376","date_updated":"2021-01-12T08:15:14Z","article_processing_charge":"No","abstract":[{"text":"Clutch size and egg mass are life history traits that have been extensively studied in wild bird populations, as life history theory predicts a negative trade‐off between them, either at the phenotypic or at the genetic level. Here, we analyse the genomic architecture of these heritable traits in a wild great tit (Parus major) population, using three marker‐based approaches – chromosome partitioning, quantitative trait locus (QTL) mapping and a genome‐wide association study (GWAS). The variance explained by each great tit chromosome scales with predicted chromosome size, no location in the genome contains genome‐wide significant QTL, and no individual SNPs are associated with a large proportion of phenotypic variation, all of which may suggest that variation in both traits is due to many loci of small effect, located across the genome. There is no evidence that any regions of the genome contribute significantly to both traits, which combined with a small, nonsignificant negative genetic covariance between the traits, suggests the absence of genetic constraints on the independent evolution of these traits. Our findings support the hypothesis that variation in life history traits in natural populations is likely to be determined by many loci of small effect spread throughout the genome, which are subject to continued input of variation by mutation and migration, although we cannot exclude the possibility of an additional input of major effect genes influencing either trait.","lang":"eng"}],"extern":"1","quality_controlled":"1"},{"status":"public","day":"01","article_type":"original","issue":"3","citation":{"ama":"Robinson MR, Beckerman AP. Quantifying multivariate plasticity: Genetic variation in resource acquisition drives plasticity in resource allocation to components of life history. <i>Ecology Letters</i>. 2013;16(3):281-290. doi:<a href=\"https://doi.org/10.1111/ele.12047\">10.1111/ele.12047</a>","short":"M.R. Robinson, A.P. Beckerman, Ecology Letters 16 (2013) 281–290.","ista":"Robinson MR, Beckerman AP. 2013. Quantifying multivariate plasticity: Genetic variation in resource acquisition drives plasticity in resource allocation to components of life history. Ecology Letters. 16(3), 281–290.","mla":"Robinson, Matthew Richard, and Andrew P. Beckerman. “Quantifying Multivariate Plasticity: Genetic Variation in Resource Acquisition Drives Plasticity in Resource Allocation to Components of Life History.” <i>Ecology Letters</i>, vol. 16, no. 3, Wiley, 2013, pp. 281–90, doi:<a href=\"https://doi.org/10.1111/ele.12047\">10.1111/ele.12047</a>.","ieee":"M. R. Robinson and A. P. Beckerman, “Quantifying multivariate plasticity: Genetic variation in resource acquisition drives plasticity in resource allocation to components of life history,” <i>Ecology Letters</i>, vol. 16, no. 3. Wiley, pp. 281–290, 2013.","chicago":"Robinson, Matthew Richard, and Andrew P. Beckerman. “Quantifying Multivariate Plasticity: Genetic Variation in Resource Acquisition Drives Plasticity in Resource Allocation to Components of Life History.” <i>Ecology Letters</i>. Wiley, 2013. <a href=\"https://doi.org/10.1111/ele.12047\">https://doi.org/10.1111/ele.12047</a>.","apa":"Robinson, M. R., &#38; Beckerman, A. P. (2013). Quantifying multivariate plasticity: Genetic variation in resource acquisition drives plasticity in resource allocation to components of life history. <i>Ecology Letters</i>. Wiley. <a href=\"https://doi.org/10.1111/ele.12047\">https://doi.org/10.1111/ele.12047</a>"},"language":[{"iso":"eng"}],"publication_identifier":{"issn":["1461-023X"]},"month":"03","page":"281-290","volume":16,"type":"journal_article","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"7747","intvolume":"        16","publication_status":"published","year":"2013","author":[{"full_name":"Robinson, Matthew Richard","id":"E5D42276-F5DA-11E9-8E24-6303E6697425","first_name":"Matthew Richard","orcid":"0000-0001-8982-8813","last_name":"Robinson"},{"full_name":"Beckerman, Andrew P.","first_name":"Andrew P.","last_name":"Beckerman"}],"date_published":"2013-03-01T00:00:00Z","doi":"10.1111/ele.12047","date_updated":"2021-01-12T08:15:15Z","article_processing_charge":"No","abstract":[{"lang":"eng","text":"Acquisition and allocation of resources are central to life‐history theory. However, empirical work typically focuses only on allocation despite the fact that relationships between fitness components may be governed by differences in the ability of individuals to acquire resources across environments. Here, we outline a statistical framework to partition the genetic basis of multivariate plasticity into independent axes of genetic variation, and quantify for the first time, the extent to which specific traits drive multitrait genotype–environment interactions. Our framework generalises to analyses of plasticity, growth and ageing. We apply this approach to a unique, large‐scale, multivariate study of acquisition, allocation and plasticity in the life history of the cricket, Gryllus firmus. We demonstrate that resource acquisition and allocation are genetically correlated, and that plasticity in trade‐offs between allocation to components of fitness is 90% dependent on genetic variance for total resource acquisition. These results suggest that genotype–environment effects for resource acquisition can maintain variation in life‐history components that are typically observed in the wild."}],"extern":"1","quality_controlled":"1","title":"Quantifying multivariate plasticity: Genetic variation in resource acquisition drives plasticity in resource allocation to components of life history","publication":"Ecology Letters","publisher":"Wiley","oa_version":"None","date_created":"2020-04-30T11:00:49Z"},{"intvolume":"         7","publication_status":"published","file":[{"file_size":530134,"checksum":"cd7183121e56251176100ccac165c95c","file_name":"IST-2018-953-v1+1_2013_Dickerson_Aberrant_neural.pdf","file_id":"5128","date_updated":"2020-07-14T12:46:35Z","content_type":"application/pdf","date_created":"2018-12-12T10:15:10Z","relation":"main_file","creator":"system","access_level":"open_access"}],"language":[{"iso":"eng"}],"month":"12","day":"27","ddc":["571"],"tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"file_date_updated":"2020-07-14T12:46:35Z","quality_controlled":"1","date_published":"2013-12-27T00:00:00Z","pubrep_id":"953","author":[{"id":"444EB89E-F248-11E8-B48F-1D18A9856A87","full_name":"Dickerson, Desiree","last_name":"Dickerson","first_name":"Desiree"},{"full_name":"Bilkey, David","first_name":"David","last_name":"Bilkey"}],"date_updated":"2021-01-12T08:00:53Z","doi":"10.3389/fnbeh.2013.00217","_id":"476","year":"2013","has_accepted_license":"1","volume":7,"type":"journal_article","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"short":"D. Dickerson, D. Bilkey, Frontiers in Behavioral Neuroscience 7 (2013).","ista":"Dickerson D, Bilkey D. 2013. Aberrant neural synchrony in the maternal immune activation model: Using translatable measures to explore targeted interventions. Frontiers in Behavioral Neuroscience. 7(DEC).","mla":"Dickerson, Desiree, and David Bilkey. “Aberrant Neural Synchrony in the Maternal Immune Activation Model: Using Translatable Measures to Explore Targeted Interventions.” <i>Frontiers in Behavioral Neuroscience</i>, vol. 7, no. DEC, Frontiers Research Foundation, 2013, doi:<a href=\"https://doi.org/10.3389/fnbeh.2013.00217\">10.3389/fnbeh.2013.00217</a>.","ama":"Dickerson D, Bilkey D. Aberrant neural synchrony in the maternal immune activation model: Using translatable measures to explore targeted interventions. <i>Frontiers in Behavioral Neuroscience</i>. 2013;7(DEC). doi:<a href=\"https://doi.org/10.3389/fnbeh.2013.00217\">10.3389/fnbeh.2013.00217</a>","apa":"Dickerson, D., &#38; Bilkey, D. (2013). Aberrant neural synchrony in the maternal immune activation model: Using translatable measures to explore targeted interventions. <i>Frontiers in Behavioral Neuroscience</i>. Frontiers Research Foundation. <a href=\"https://doi.org/10.3389/fnbeh.2013.00217\">https://doi.org/10.3389/fnbeh.2013.00217</a>","chicago":"Dickerson, Desiree, and David Bilkey. “Aberrant Neural Synchrony in the Maternal Immune Activation Model: Using Translatable Measures to Explore Targeted Interventions.” <i>Frontiers in Behavioral Neuroscience</i>. Frontiers Research Foundation, 2013. <a href=\"https://doi.org/10.3389/fnbeh.2013.00217\">https://doi.org/10.3389/fnbeh.2013.00217</a>.","ieee":"D. Dickerson and D. Bilkey, “Aberrant neural synchrony in the maternal immune activation model: Using translatable measures to explore targeted interventions,” <i>Frontiers in Behavioral Neuroscience</i>, vol. 7, no. DEC. Frontiers Research Foundation, 2013."},"status":"public","oa":1,"issue":"DEC","oa_version":"Published Version","date_created":"2018-12-11T11:46:41Z","publist_id":"7346","title":"Aberrant neural synchrony in the maternal immune activation model: Using translatable measures to explore targeted interventions","department":[{"_id":"JoCs"}],"publication":"Frontiers in Behavioral Neuroscience","publisher":"Frontiers Research Foundation","abstract":[{"text":"Maternal exposure to infection occurring mid-gestation produces a three-fold increase in the risk of schizophrenia in the offspring. The critical initiating factor appears to be the maternal immune activation (MIA) that follows infection. This process can be induced in rodents by exposure of pregnant dams to the viral mimic Poly I:C, which triggers an immune response that results in structural, functional, behavioral, and electrophysiological phenotypes in the adult offspring that model those seen in schizophrenia. We used this model to explore the role of synchronization in brain neural networks, a process thought to be dysfunctional in schizophrenia and previously associated with positive, negative, and cognitive symptoms of schizophrenia. Exposure of pregnant dams to Poly I:C on GD15 produced an impairment in long-range neural synchrony in adult offspring between two regions implicated in schizophrenia pathology; the hippocampus and the medial prefrontal cortex (mPFC). This reduction in synchrony was ameliorated by acute doses of the antipsychotic clozapine. MIA animals have previously been shown to have impaired pre-pulse inhibition (PPI), a gold-standard measure of schizophrenia-like deficits in animal models. Our data showed that deficits in synchrony were positively correlated with the impairments in PPI. Subsequent analysis of LFP activity during the PPI response also showed that reduced coupling between the mPFC and the hippocampus following processing of the pre-pulse was associated with reduced PPI. The ability of the MIA intervention to model neurodevelopmental aspects of schizophrenia pathology provides a useful platform from which to investigate the ontogeny of aberrant synchronous processes. Further, the way in which the model expresses translatable deficits such as aberrant synchrony and reduced PPI will allow researchers to explore novel intervention strategies targeted to these changes. ","lang":"eng"}]},{"_id":"499","intvolume":"       339","publication_status":"published","year":"2013","page":"91 - 95","volume":339,"type":"journal_article","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"chicago":"Wakamoto, Yurichi, Neraaj Dhar, Remy P Chait, Katrin Schneider, François Signorino Gelo, Stanislas Leibler, and John Mckinney. “Dynamic Persistence of Antibiotic-Stressed Mycobacteria.” <i>Science</i>. American Association for the Advancement of Science, 2013. <a href=\"https://doi.org/10.1126/science.1229858\">https://doi.org/10.1126/science.1229858</a>.","ieee":"Y. Wakamoto <i>et al.</i>, “Dynamic persistence of antibiotic-stressed mycobacteria,” <i>Science</i>, vol. 339, no. 6115. American Association for the Advancement of Science, pp. 91–95, 2013.","apa":"Wakamoto, Y., Dhar, N., Chait, R. P., Schneider, K., Signorino Gelo, F., Leibler, S., &#38; Mckinney, J. (2013). Dynamic persistence of antibiotic-stressed mycobacteria. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1229858\">https://doi.org/10.1126/science.1229858</a>","ama":"Wakamoto Y, Dhar N, Chait RP, et al. Dynamic persistence of antibiotic-stressed mycobacteria. <i>Science</i>. 2013;339(6115):91-95. doi:<a href=\"https://doi.org/10.1126/science.1229858\">10.1126/science.1229858</a>","short":"Y. Wakamoto, N. Dhar, R.P. Chait, K. Schneider, F. Signorino Gelo, S. Leibler, J. Mckinney, Science 339 (2013) 91–95.","mla":"Wakamoto, Yurichi, et al. “Dynamic Persistence of Antibiotic-Stressed Mycobacteria.” <i>Science</i>, vol. 339, no. 6115, American Association for the Advancement of Science, 2013, pp. 91–95, doi:<a href=\"https://doi.org/10.1126/science.1229858\">10.1126/science.1229858</a>.","ista":"Wakamoto Y, Dhar N, Chait RP, Schneider K, Signorino Gelo F, Leibler S, Mckinney J. 2013. Dynamic persistence of antibiotic-stressed mycobacteria. Science. 339(6115), 91–95."},"language":[{"iso":"eng"}],"month":"01","status":"public","day":"04","issue":"6115","oa_version":"None","date_created":"2018-12-11T11:46:48Z","publist_id":"7321","title":"Dynamic persistence of antibiotic-stressed mycobacteria","department":[{"_id":"CaGu"},{"_id":"GaTk"}],"publication":"Science","publisher":"American Association for the Advancement of Science","abstract":[{"lang":"eng","text":"Exposure of an isogenic bacterial population to a cidal antibiotic typically fails to eliminate a small fraction of refractory cells. Historically, fractional killing has been attributed to infrequently dividing or nondividing &quot;persisters.&quot; Using microfluidic cultures and time-lapse microscopy, we found that Mycobacterium smegmatis persists by dividing in the presence of the drug isoniazid (INH). Although persistence in these studies was characterized by stable numbers of cells, this apparent stability was actually a dynamic state of balanced division and death. Single cells expressed catalase-peroxidase (KatG), which activates INH, in stochastic pulses that were negatively correlated with cell survival. These behaviors may reflect epigenetic effects, because KatG pulsing and death were correlated between sibling cells. Selection of lineages characterized by infrequent KatG pulsing could allow nonresponsive adaptation during prolonged drug exposure."}],"scopus_import":1,"quality_controlled":"1","author":[{"full_name":"Wakamoto, Yurichi","last_name":"Wakamoto","first_name":"Yurichi"},{"full_name":"Dhar, Neraaj","last_name":"Dhar","first_name":"Neraaj"},{"orcid":"0000-0003-0876-3187","last_name":"Chait","first_name":"Remy P","id":"3464AE84-F248-11E8-B48F-1D18A9856A87","full_name":"Chait, Remy P"},{"full_name":"Schneider, Katrin","first_name":"Katrin","last_name":"Schneider"},{"first_name":"François","last_name":"Signorino Gelo","full_name":"Signorino Gelo, François"},{"first_name":"Stanislas","last_name":"Leibler","full_name":"Leibler, Stanislas"},{"full_name":"Mckinney, John","last_name":"Mckinney","first_name":"John"}],"date_published":"2013-01-04T00:00:00Z","date_updated":"2021-01-12T08:01:06Z","doi":"10.1126/science.1229858"},{"intvolume":"        13","publication_status":"published","file":[{"date_updated":"2020-07-14T12:46:36Z","file_id":"4722","file_size":1150052,"file_name":"IST-2018-941-v1+1_2013_Bollback_Evolutionary_interactionspdf.pdf","checksum":"52cf48a7c1794676ae8b0029573a84a9","relation":"main_file","access_level":"open_access","creator":"system","content_type":"application/pdf","date_created":"2018-12-12T10:08:59Z"}],"language":[{"iso":"eng"}],"month":"10","day":"09","ddc":["576"],"tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"file_date_updated":"2020-07-14T12:46:36Z","article_number":"222","scopus_import":1,"quality_controlled":"1","author":[{"last_name":"Ward","first_name":"Melissa","full_name":"Ward, Melissa"},{"last_name":"Lycett","first_name":"Samantha","full_name":"Lycett, Samantha"},{"full_name":"Avila, Dorita","last_name":"Avila","first_name":"Dorita"},{"orcid":"0000-0002-4624-4612","last_name":"Bollback","first_name":"Jonathan P","id":"2C6FA9CC-F248-11E8-B48F-1D18A9856A87","full_name":"Bollback, Jonathan P"},{"full_name":"Leigh Brown, Andrew","first_name":"Andrew","last_name":"Leigh Brown"}],"pubrep_id":"941","date_published":"2013-10-09T00:00:00Z","date_updated":"2021-01-12T08:01:08Z","doi":"10.1186/1471-2148-13-222","_id":"500","year":"2013","has_accepted_license":"1","volume":13,"type":"journal_article","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"apa":"Ward, M., Lycett, S., Avila, D., Bollback, J. P., &#38; Leigh Brown, A. (2013). Evolutionary interactions between haemagglutinin and neuraminidase in avian influenza. <i>BMC Evolutionary Biology</i>. BioMed Central. <a href=\"https://doi.org/10.1186/1471-2148-13-222\">https://doi.org/10.1186/1471-2148-13-222</a>","chicago":"Ward, Melissa, Samantha Lycett, Dorita Avila, Jonathan P Bollback, and Andrew Leigh Brown. “Evolutionary Interactions between Haemagglutinin and Neuraminidase in Avian Influenza.” <i>BMC Evolutionary Biology</i>. BioMed Central, 2013. <a href=\"https://doi.org/10.1186/1471-2148-13-222\">https://doi.org/10.1186/1471-2148-13-222</a>.","ieee":"M. Ward, S. Lycett, D. Avila, J. P. Bollback, and A. Leigh Brown, “Evolutionary interactions between haemagglutinin and neuraminidase in avian influenza,” <i>BMC Evolutionary Biology</i>, vol. 13, no. 1. BioMed Central, 2013.","short":"M. Ward, S. Lycett, D. Avila, J.P. Bollback, A. Leigh Brown, BMC Evolutionary Biology 13 (2013).","mla":"Ward, Melissa, et al. “Evolutionary Interactions between Haemagglutinin and Neuraminidase in Avian Influenza.” <i>BMC Evolutionary Biology</i>, vol. 13, no. 1, 222, BioMed Central, 2013, doi:<a href=\"https://doi.org/10.1186/1471-2148-13-222\">10.1186/1471-2148-13-222</a>.","ista":"Ward M, Lycett S, Avila D, Bollback JP, Leigh Brown A. 2013. Evolutionary interactions between haemagglutinin and neuraminidase in avian influenza. BMC Evolutionary Biology. 13(1), 222.","ama":"Ward M, Lycett S, Avila D, Bollback JP, Leigh Brown A. Evolutionary interactions between haemagglutinin and neuraminidase in avian influenza. <i>BMC Evolutionary Biology</i>. 2013;13(1). doi:<a href=\"https://doi.org/10.1186/1471-2148-13-222\">10.1186/1471-2148-13-222</a>"},"oa":1,"acknowledgement":"This work was supported by the Biotechnology and Biological Sciences Research Council, the Government of the Republic of Panama, the Interdisciplinary Centre for Human and Avian Influenza Research (www.ichair-flu.org) funded by the Scottish Funding Council, and the Institute for Science and Technology Austria.\r\nCC BY 2.0\r\n","status":"public","issue":"1","oa_version":"Published Version","date_created":"2018-12-11T11:46:49Z","publist_id":"7320","department":[{"_id":"JoBo"}],"title":"Evolutionary interactions between haemagglutinin and neuraminidase in avian influenza","publication":"BMC Evolutionary Biology","publisher":"BioMed Central","abstract":[{"text":"Background: Reassortment between the RNA segments encoding haemagglutinin (HA) and neuraminidase (NA), the major antigenic influenza proteins, produces viruses with novel HA and NA subtype combinations and has preceded the emergence of pandemic strains. It has been suggested that productive viral infection requires a balance in the level of functional activity of HA and NA, arising from their closely interacting roles in the viral life cycle, and that this functional balance could be mediated by genetic changes in the HA and NA. Here, we investigate how the selective pressure varies for H7 avian influenza HA on different NA subtype backgrounds. Results: By extending Bayesian stochastic mutational mapping methods to calculate the ratio of the rate of non-synonymous change to the rate of synonymous change (d N/d S), we found the average d N/d S across the avian influenza H7 HA1 region to be significantly greater on an N2 NA subtype background than on an N1, N3 or N7 background. Observed differences in evolutionary rates of H7 HA on different NA subtype backgrounds could not be attributed to underlying differences between avian host species or virus pathogenicity. Examination of d N/d S values for each subtype on a site-by-site basis indicated that the elevated d N/d S on the N2 NA background was a result of increased selection, rather than a relaxation of selective constraint. Conclusions: Our results are consistent with the hypothesis that reassortment exposes influenza HA to significant changes in selective pressure through genetic interactions with NA. Such epistatic effects might be explicitly accounted for in future models of influenza evolution.","lang":"eng"}]},{"file":[{"content_type":"application/pdf","date_created":"2018-12-12T10:12:59Z","relation":"main_file","creator":"system","access_level":"open_access","file_size":1040765,"checksum":"8007815078dccac21ecd1cf73a269dc6","file_name":"IST-2018-940-v1+1_2013_Redondo_A_new.pdf","date_updated":"2020-07-14T12:46:36Z","file_id":"4980"}],"publication_status":"published","intvolume":"        94","license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","month":"12","language":[{"iso":"eng"}],"ddc":["570"],"day":"01","tmp":{"short":"CC BY-NC-ND (4.0)","image":"/images/cc_by_nc_nd.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)"},"file_date_updated":"2020-07-14T12:46:36Z","quality_controlled":"1","scopus_import":1,"date_updated":"2021-01-12T08:01:09Z","doi":"10.1644/12-MAMM-A-169.1","author":[{"full_name":"Cozzuol, Mario","last_name":"Cozzuol","first_name":"Mario"},{"full_name":"Clozato, Camila","first_name":"Camila","last_name":"Clozato"},{"full_name":"Holanda, Elizete","last_name":"Holanda","first_name":"Elizete"},{"full_name":"Rodrigues, Flávio","first_name":"Flávio","last_name":"Rodrigues"},{"first_name":"Samuel","last_name":"Nienow","full_name":"Nienow, Samuel"},{"full_name":"De Thoisy, Benoit","last_name":"De Thoisy","first_name":"Benoit"},{"last_name":"Fernandes Redondo","orcid":"0000-0002-5837-2793","first_name":"Rodrigo A","id":"409D5C96-F248-11E8-B48F-1D18A9856A87","full_name":"Fernandes Redondo, Rodrigo A"},{"full_name":"Santos, Fabrício","last_name":"Santos","first_name":"Fabrício"}],"pubrep_id":"940","date_published":"2013-12-01T00:00:00Z","has_accepted_license":"1","year":"2013","_id":"501","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"journal_article","volume":94,"page":"1331 - 1345","citation":{"apa":"Cozzuol, M., Clozato, C., Holanda, E., Rodrigues, F., Nienow, S., De Thoisy, B., … Santos, F. (2013). A new species of tapir from the Amazon. <i>Journal of Mammalogy</i>. Oxford University Press. <a href=\"https://doi.org/10.1644/12-MAMM-A-169.1\">https://doi.org/10.1644/12-MAMM-A-169.1</a>","chicago":"Cozzuol, Mario, Camila Clozato, Elizete Holanda, Flávio Rodrigues, Samuel Nienow, Benoit De Thoisy, Rodrigo A Fernandes Redondo, and Fabrício Santos. “A New Species of Tapir from the Amazon.” <i>Journal of Mammalogy</i>. Oxford University Press, 2013. <a href=\"https://doi.org/10.1644/12-MAMM-A-169.1\">https://doi.org/10.1644/12-MAMM-A-169.1</a>.","ieee":"M. Cozzuol <i>et al.</i>, “A new species of tapir from the Amazon,” <i>Journal of Mammalogy</i>, vol. 94, no. 6. Oxford University Press, pp. 1331–1345, 2013.","mla":"Cozzuol, Mario, et al. “A New Species of Tapir from the Amazon.” <i>Journal of Mammalogy</i>, vol. 94, no. 6, Oxford University Press, 2013, pp. 1331–45, doi:<a href=\"https://doi.org/10.1644/12-MAMM-A-169.1\">10.1644/12-MAMM-A-169.1</a>.","ista":"Cozzuol M, Clozato C, Holanda E, Rodrigues F, Nienow S, De Thoisy B, Fernandes Redondo RA, Santos F. 2013. A new species of tapir from the Amazon. Journal of Mammalogy. 94(6), 1331–1345.","short":"M. Cozzuol, C. Clozato, E. Holanda, F. Rodrigues, S. Nienow, B. De Thoisy, R.A. Fernandes Redondo, F. Santos, Journal of Mammalogy 94 (2013) 1331–1345.","ama":"Cozzuol M, Clozato C, Holanda E, et al. A new species of tapir from the Amazon. <i>Journal of Mammalogy</i>. 2013;94(6):1331-1345. doi:<a href=\"https://doi.org/10.1644/12-MAMM-A-169.1\">10.1644/12-MAMM-A-169.1</a>"},"issue":"6","oa":1,"status":"public","publist_id":"7319","date_created":"2018-12-11T11:46:49Z","oa_version":"Published Version","publisher":"Oxford University Press","publication":"Journal of Mammalogy","title":"A new species of tapir from the Amazon","department":[{"_id":"JoBo"}],"abstract":[{"lang":"eng","text":"All known species of extant tapirs are allopatric: 1 in southeastern Asia and 3 in Central and South America. The fossil record for tapirs, however, is much wider in geographical range, including Europe, Asia, and North and South America, going back to the late Oligocene, making the present distribution a relict of the original one. We here describe a new species of living Tapirus from the Amazon rain forest, the 1st since T. bairdii Gill, 1865, and the 1st new Perissodactyla in more than 100 years, from both morphological and molecular characters. It is shorter in stature than T. terrestris (Linnaeus, 1758) and has distinctive skull morphology, and it is basal to the clade formed by T. terrestris and T. pinchaque (Roulin, 1829). This highlights the unrecognized biodiversity in western Amazonia, where the biota faces increasing threats. Local peoples have long recognized our new species, suggesting a key role for traditional knowledge in understanding the biodiversity of the region."}]},{"date_updated":"2021-01-12T08:01:09Z","doi":"10.3233/JCS-130477","date_published":"2013-11-22T00:00:00Z","author":[{"full_name":"Blazy, Olivier","last_name":"Blazy","first_name":"Olivier"},{"full_name":"Fuchsbauer, Georg","id":"46B4C3EE-F248-11E8-B48F-1D18A9856A87","first_name":"Georg","last_name":"Fuchsbauer"},{"full_name":"Pointcheval, David","first_name":"David","last_name":"Pointcheval"},{"last_name":"Vergnaud","first_name":"Damien","full_name":"Vergnaud, Damien"}],"quality_controlled":"1","abstract":[{"text":"Blind signatures allow users to obtain signatures on messages hidden from the signer; moreover, the signer cannot link the resulting message/signature pair to the signing session. This paper presents blind signature schemes, in which the number of interactions between the user and the signer is minimal and whose blind signatures are short. Our schemes are defined over bilinear groups and are proved secure in the common-reference-string model without random oracles and under standard assumptions: CDH and the decision-linear assumption. (We also give variants over asymmetric groups based on similar assumptions.) The blind signatures are Waters signatures, which consist of 2 group elements. Moreover, we instantiate partially blind signatures, where the message consists of a part hidden from the signer and a commonly known public part, and schemes achieving perfect blindness. We propose new variants of blind signatures, such as signer-friendly partially blind signatures, where the public part can be chosen by the signer without prior agreement, 3-party blind signatures, as well as blind signatures on multiple aggregated messages provided by independent sources. We also extend Waters signatures to non-binary alphabets by proving a new result on the underlying hash function. ","lang":"eng"}],"scopus_import":1,"publisher":"IOS Press","publication":"Journal of Computer Security","department":[{"_id":"KrPi"}],"title":"Short blind signatures","publist_id":"7318","date_created":"2018-12-11T11:46:50Z","oa_version":"None","issue":"5","day":"22","status":"public","month":"11","language":[{"iso":"eng"}],"citation":{"apa":"Blazy, O., Fuchsbauer, G., Pointcheval, D., &#38; Vergnaud, D. (2013). Short blind signatures. <i>Journal of Computer Security</i>. IOS Press. <a href=\"https://doi.org/10.3233/JCS-130477\">https://doi.org/10.3233/JCS-130477</a>","chicago":"Blazy, Olivier, Georg Fuchsbauer, David Pointcheval, and Damien Vergnaud. “Short Blind Signatures.” <i>Journal of Computer Security</i>. IOS Press, 2013. <a href=\"https://doi.org/10.3233/JCS-130477\">https://doi.org/10.3233/JCS-130477</a>.","ieee":"O. Blazy, G. Fuchsbauer, D. Pointcheval, and D. Vergnaud, “Short blind signatures,” <i>Journal of Computer Security</i>, vol. 21, no. 5. IOS Press, pp. 627–661, 2013.","mla":"Blazy, Olivier, et al. “Short Blind Signatures.” <i>Journal of Computer Security</i>, vol. 21, no. 5, IOS Press, 2013, pp. 627–61, doi:<a href=\"https://doi.org/10.3233/JCS-130477\">10.3233/JCS-130477</a>.","short":"O. Blazy, G. Fuchsbauer, D. Pointcheval, D. Vergnaud, Journal of Computer Security 21 (2013) 627–661.","ista":"Blazy O, Fuchsbauer G, Pointcheval D, Vergnaud D. 2013. Short blind signatures. Journal of Computer Security. 21(5), 627–661.","ama":"Blazy O, Fuchsbauer G, Pointcheval D, Vergnaud D. Short blind signatures. <i>Journal of Computer Security</i>. 2013;21(5):627-661. doi:<a href=\"https://doi.org/10.3233/JCS-130477\">10.3233/JCS-130477</a>"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"journal_article","volume":21,"page":"627 - 661","year":"2013","publication_status":"published","_id":"502","intvolume":"        21"},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"journal_article","volume":15,"page":"381 - 388","year":"2013","publication_status":"published","intvolume":"        15","_id":"505","issue":"2","day":"01","acknowledgement":"This study was performed within the Austrian Centre of Indus-\r\ntrial Biotechnology ACIB and the COST Action 868. This work\r\nhas been supported by the Federal Ministry of Economy,\r\nFamily and Youth (BMWFJ), the Federal Ministry of Tra\r\nffi\r\nc,\r\nInnovation and Technology (bmvit), the Styrian Business\r\nPromotion Agency SFG, the Standortagentur Tirol and ZIT\r\n–\r\nTechnology  Agency  of  the  City  of  Vienna  through  the\r\nCOMET-Funding Program managed by the Austrian Research\r\nPromotion Agency FFG. Dr Massimiliano Cardinale (Institute of\r\nEnvironmental Biotechnology, TU Graz) is gratefully acknowl-\r\nedged for technical support with the CLSM measurements.","status":"public","month":"02","language":[{"iso":"eng"}],"citation":{"ama":"Greimel K, Perz V, Koren K, et al. Banning toxic heavy-metal catalysts from paints: Enzymatic cross-linking of alkyd resins. <i>Green Chemistry</i>. 2013;15(2):381-388. doi:<a href=\"https://doi.org/10.1039/c2gc36666e\">10.1039/c2gc36666e</a>","mla":"Greimel, Katrin, et al. “Banning Toxic Heavy-Metal Catalysts from Paints: Enzymatic Cross-Linking of Alkyd Resins.” <i>Green Chemistry</i>, vol. 15, no. 2, Royal Society of Chemistry, 2013, pp. 381–88, doi:<a href=\"https://doi.org/10.1039/c2gc36666e\">10.1039/c2gc36666e</a>.","ista":"Greimel K, Perz V, Koren K, Feola R, Temel A, Sohar C, Herrero Acero E, Klimant I, Guebitz G. 2013. Banning toxic heavy-metal catalysts from paints: Enzymatic cross-linking of alkyd resins. Green Chemistry. 15(2), 381–388.","short":"K. Greimel, V. Perz, K. Koren, R. Feola, A. Temel, C. Sohar, E. Herrero Acero, I. Klimant, G. Guebitz, Green Chemistry 15 (2013) 381–388.","chicago":"Greimel, Katrin, Veronika Perz, Klaus Koren, Roland Feola, Armin Temel, Christian Sohar, Enrique Herrero Acero, Ingo Klimant, and Georg Guebitz. “Banning Toxic Heavy-Metal Catalysts from Paints: Enzymatic Cross-Linking of Alkyd Resins.” <i>Green Chemistry</i>. Royal Society of Chemistry, 2013. <a href=\"https://doi.org/10.1039/c2gc36666e\">https://doi.org/10.1039/c2gc36666e</a>.","ieee":"K. Greimel <i>et al.</i>, “Banning toxic heavy-metal catalysts from paints: Enzymatic cross-linking of alkyd resins,” <i>Green Chemistry</i>, vol. 15, no. 2. Royal Society of Chemistry, pp. 381–388, 2013.","apa":"Greimel, K., Perz, V., Koren, K., Feola, R., Temel, A., Sohar, C., … Guebitz, G. (2013). Banning toxic heavy-metal catalysts from paints: Enzymatic cross-linking of alkyd resins. <i>Green Chemistry</i>. Royal Society of Chemistry. <a href=\"https://doi.org/10.1039/c2gc36666e\">https://doi.org/10.1039/c2gc36666e</a>"},"publisher":"Royal Society of Chemistry","publication":"Green Chemistry","title":"Banning toxic heavy-metal catalysts from paints: Enzymatic cross-linking of alkyd resins","department":[{"_id":"HaJa"}],"publist_id":"7313","date_created":"2018-12-11T11:46:51Z","oa_version":"None","date_updated":"2021-01-12T08:01:11Z","doi":"10.1039/c2gc36666e","author":[{"full_name":"Greimel, Katrin","last_name":"Greimel","first_name":"Katrin"},{"full_name":"Perz, Veronika","first_name":"Veronika","last_name":"Perz"},{"last_name":"Koren","first_name":"Klaus","id":"382FBD6A-F248-11E8-B48F-1D18A9856A87","full_name":"Koren, Klaus"},{"last_name":"Feola","first_name":"Roland","full_name":"Feola, Roland"},{"last_name":"Temel","first_name":"Armin","full_name":"Temel, Armin"},{"first_name":"Christian","last_name":"Sohar","full_name":"Sohar, Christian"},{"full_name":"Herrero Acero, Enrique","first_name":"Enrique","last_name":"Herrero Acero"},{"full_name":"Klimant, Ingo","last_name":"Klimant","first_name":"Ingo"},{"full_name":"Guebitz, Georg","last_name":"Guebitz","first_name":"Georg"}],"date_published":"2013-02-01T00:00:00Z","quality_controlled":"1","abstract":[{"text":"Alkyd resins are polyesters containing unsaturated fatty acids that are used as binding agents in paints and coatings. Chemical drying of these polyesters is based on heavy metal catalyzed cross-linking of the unsaturated fatty acid moieties. Among the heavy-metal catalysts, cobalt complexes are the most effective, yet they have been proven to be carcinogenic. Therefore, strategies to replace the cobalt-based catalyst by environmentally friendlier and less toxic alternatives are under development. Here, we demonstrate for the first time that a laccase-mediator system can effectively replace the heavy-metal catalyst and cross-link alkyd resins. Interestingly, the biocatalytic reaction does not only work in aqueous media, but also in a solid film, where enzyme diffusion is limited. Within the catalytic cycle, the mediator oxidizes the alkyd resin and is regenerated by the laccase, which is uniformly distributed within the drying film as evidenced by confocal laser scanning microscopy. During gradual build-up of molecular weight, there is a concomitant decrease of the oxygen content in the film. A new optical sensor to follow oxygen consumption during the cross-linking reaction was developed and validated with state of the art techniques. A remarkable feature is the low sample amount required, which allows faster screening of new catalysts.","lang":"eng"}],"scopus_import":1},{"citation":{"short":"S. Kim, Z. Xu, K. Song, D. Kim, H. Kang, I. Reichardt, E. Sohn, J. Friml, G. Juergens, I. Hwang, Plant Cell 25 (2013) 2970–2985.","ista":"Kim S, Xu Z, Song K, Kim D, Kang H, Reichardt I, Sohn E, Friml J, Juergens G, Hwang I. 2013. Adaptor protein complex 2-mediated endocytosis is crucial for male reproductive organ development in arabidopsis. Plant Cell. 25(8), 2970–2985.","mla":"Kim, Soo, et al. “Adaptor Protein Complex 2-Mediated Endocytosis Is Crucial for Male Reproductive Organ Development in Arabidopsis.” <i>Plant Cell</i>, vol. 25, no. 8, American Society of Plant Biologists, 2013, pp. 2970–85, doi:<a href=\"https://doi.org/10.1105/tpc.113.114264\">10.1105/tpc.113.114264</a>.","ama":"Kim S, Xu Z, Song K, et al. Adaptor protein complex 2-mediated endocytosis is crucial for male reproductive organ development in arabidopsis. <i>Plant Cell</i>. 2013;25(8):2970-2985. doi:<a href=\"https://doi.org/10.1105/tpc.113.114264\">10.1105/tpc.113.114264</a>","apa":"Kim, S., Xu, Z., Song, K., Kim, D., Kang, H., Reichardt, I., … Hwang, I. (2013). Adaptor protein complex 2-mediated endocytosis is crucial for male reproductive organ development in arabidopsis. <i>Plant Cell</i>. American Society of Plant Biologists. <a href=\"https://doi.org/10.1105/tpc.113.114264\">https://doi.org/10.1105/tpc.113.114264</a>","chicago":"Kim, Soo, Zheng Xu, Kyungyoung Song, Dae Kim, Hyangju Kang, Ilka Reichardt, Eun Sohn, Jiří Friml, Gerd Juergens, and Inhwan Hwang. “Adaptor Protein Complex 2-Mediated Endocytosis Is Crucial for Male Reproductive Organ Development in Arabidopsis.” <i>Plant Cell</i>. American Society of Plant Biologists, 2013. <a href=\"https://doi.org/10.1105/tpc.113.114264\">https://doi.org/10.1105/tpc.113.114264</a>.","ieee":"S. Kim <i>et al.</i>, “Adaptor protein complex 2-mediated endocytosis is crucial for male reproductive organ development in arabidopsis,” <i>Plant Cell</i>, vol. 25, no. 8. American Society of Plant Biologists, pp. 2970–2985, 2013."},"oa":1,"status":"public","external_id":{"pmid":["23975898"]},"issue":"8","_id":"507","year":"2013","page":"2970 - 2985","volume":25,"type":"journal_article","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","abstract":[{"text":"Fertilization in flowering plants requires the temporal and spatial coordination of many developmental processes, including pollen production, anther dehiscence, ovule production, and pollen tube elongation. However, it remains elusive as to how this coordination occurs during reproduction. Here, we present evidence that endocytosis, involving heterotetrameric adaptor protein complex 2 (AP-2), plays a crucial role in fertilization. An Arabidopsis thaliana mutant ap2m displays multiple defects in pollen production and viability, as well as elongation of staminal filaments and pollen tubes, all of which are pivotal processes needed for fertilization. Of these abnormalities, the defects in elongation of staminal filaments and pollen tubes were partially rescued by exogenous auxin. Moreover, DR5rev:GFP (for green fluorescent protein) expression was greatly reduced in filaments and anthers in ap2m mutant plants. At the cellular level, ap2m mutants displayed defects in both endocytosis of N-(3-triethylammonium-propyl)-4- (4-diethylaminophenylhexatrienyl) pyridinium dibromide, a lypophilic dye used as an endocytosis marker, and polar localization of auxin-efflux carrier PIN FORMED2 (PIN2) in the stamen filaments. Moreover, these defects were phenocopied by treatment with Tyrphostin A23, an inhibitor of endocytosis. Based on these results, we propose that AP-2-dependent endocytosis plays a crucial role in coordinating the multiple developmental aspects of male reproductive organs by modulating cellular auxin level through the regulation of the amount and polarity of PINs.","lang":"eng"}],"oa_version":"Submitted Version","date_created":"2018-12-11T11:46:52Z","publist_id":"7312","department":[{"_id":"JiFr"}],"title":"Adaptor protein complex 2-mediated endocytosis is crucial for male reproductive organ development in arabidopsis","publication":"Plant Cell","publisher":"American Society of Plant Biologists","language":[{"iso":"eng"}],"month":"08","pmid":1,"day":"01","main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784592/","open_access":"1"}],"intvolume":"        25","publication_status":"published","scopus_import":1,"quality_controlled":"1","date_published":"2013-08-01T00:00:00Z","author":[{"last_name":"Kim","first_name":"Soo","full_name":"Kim, Soo"},{"full_name":"Xu, Zheng","first_name":"Zheng","last_name":"Xu"},{"first_name":"Kyungyoung","last_name":"Song","full_name":"Song, Kyungyoung"},{"full_name":"Kim, Dae","first_name":"Dae","last_name":"Kim"},{"last_name":"Kang","first_name":"Hyangju","full_name":"Kang, Hyangju"},{"full_name":"Reichardt, Ilka","last_name":"Reichardt","first_name":"Ilka"},{"full_name":"Sohn, Eun","last_name":"Sohn","first_name":"Eun"},{"last_name":"Friml","orcid":"0000-0002-8302-7596","first_name":"Jirí","id":"4159519E-F248-11E8-B48F-1D18A9856A87","full_name":"Friml, Jirí"},{"last_name":"Juergens","first_name":"Gerd","full_name":"Juergens, Gerd"},{"first_name":"Inhwan","last_name":"Hwang","full_name":"Hwang, Inhwan"}],"doi":"10.1105/tpc.113.114264","date_updated":"2021-01-12T08:01:12Z"},{"scopus_import":1,"quality_controlled":"1","author":[{"last_name":"Tarazona Santos","first_name":"Eduardo","full_name":"Tarazona Santos, Eduardo"},{"full_name":"Machado, Moara","first_name":"Moara","last_name":"Machado"},{"first_name":"Wagner","last_name":"Magalhães","full_name":"Magalhães, Wagner"},{"last_name":"Chen","first_name":"Renee","full_name":"Chen, Renee"},{"last_name":"Lyon","first_name":"Fernanda","full_name":"Lyon, Fernanda"},{"first_name":"Laurie","last_name":"Burdett","full_name":"Burdett, Laurie"},{"full_name":"Crenshaw, Andrew","first_name":"Andrew","last_name":"Crenshaw"},{"full_name":"Fabbri, Cristina","last_name":"Fabbri","first_name":"Cristina"},{"last_name":"Pereira","first_name":"Latife","full_name":"Pereira, Latife"},{"full_name":"Pinto, Laelia","first_name":"Laelia","last_name":"Pinto"},{"id":"409D5C96-F248-11E8-B48F-1D18A9856A87","full_name":"Fernandes Redondo, Rodrigo A","orcid":"0000-0002-5837-2793","last_name":"Fernandes Redondo","first_name":"Rodrigo A"},{"first_name":"Ben","last_name":"Sestanovich","full_name":"Sestanovich, Ben"},{"full_name":"Yeager, Meredith","last_name":"Yeager","first_name":"Meredith"},{"first_name":"Stephen","last_name":"Chanock","full_name":"Chanock, Stephen"}],"date_published":"2013-09-01T00:00:00Z","date_updated":"2021-01-12T08:01:12Z","doi":"10.1093/molbev/mst119","main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748357/"}],"intvolume":"        30","publication_status":"published","language":[{"iso":"eng"}],"month":"09","pmid":1,"day":"01","oa_version":"Submitted Version","date_created":"2018-12-11T11:46:52Z","publist_id":"7310","department":[{"_id":"JoBo"}],"title":"Evolutionary dynamics of the human NADPH oxidase genes CYBB, CYBA, NCF2, and NCF4: Functional implications","publication":"Molecular Biology and Evolution","publisher":"Oxford University Press","abstract":[{"text":"The phagocyte NADPH oxidase catalyzes the reduction of O2 to reactive oxygen species with microbicidal activity. It is composed of two membrane-spanning subunits, gp91-phox and p22-phox (encoded by CYBB and CYBA, respectively), and three cytoplasmic subunits, p40-phox, p47-phox, and p67-phox (encoded by NCF4, NCF1, and NCF2, respectively). Mutations in any of these genes can result in chronic granulomatous disease, a primary immunodeficiency characterized by recurrent infections. Using evolutionary mapping, we determined that episodes of adaptive natural selection have shaped the extracellular portion of gp91-phox during the evolution of mammals, which suggests that this region may have a function in host-pathogen interactions. On the basis of a resequencing analysis of approximately 35 kb of CYBB, CYBA, NCF2, and NCF4 in 102 ethnically diverse individuals (24 of African ancestry, 31 of European ancestry, 24 of Asian/Oceanians, and 23 US Hispanics), we show that the pattern of CYBA diversity is compatible with balancing natural selection, perhaps mediated by catalase-positive pathogens. NCF2 in Asian populations shows a pattern of diversity characterized by a differentiated haplotype structure. Our study provides insight into the role of pathogen-driven natural selection in an innate immune pathway and sheds light on the role of CYBA in endothelial, nonphagocytic NADPH oxidases, which are relevant in the pathogenesis of cardiovascular and other complex diseases.","lang":"eng"}],"_id":"508","year":"2013","page":"2157 - 2167","volume":30,"type":"journal_article","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"ama":"Tarazona Santos E, Machado M, Magalhães W, et al. Evolutionary dynamics of the human NADPH oxidase genes CYBB, CYBA, NCF2, and NCF4: Functional implications. <i>Molecular Biology and Evolution</i>. 2013;30(9):2157-2167. doi:<a href=\"https://doi.org/10.1093/molbev/mst119\">10.1093/molbev/mst119</a>","short":"E. Tarazona Santos, M. Machado, W. Magalhães, R. Chen, F. Lyon, L. Burdett, A. Crenshaw, C. Fabbri, L. Pereira, L. Pinto, R.A. Fernandes Redondo, B. Sestanovich, M. Yeager, S. Chanock, Molecular Biology and Evolution 30 (2013) 2157–2167.","mla":"Tarazona Santos, Eduardo, et al. “Evolutionary Dynamics of the Human NADPH Oxidase Genes CYBB, CYBA, NCF2, and NCF4: Functional Implications.” <i>Molecular Biology and Evolution</i>, vol. 30, no. 9, Oxford University Press, 2013, pp. 2157–67, doi:<a href=\"https://doi.org/10.1093/molbev/mst119\">10.1093/molbev/mst119</a>.","ista":"Tarazona Santos E, Machado M, Magalhães W, Chen R, Lyon F, Burdett L, Crenshaw A, Fabbri C, Pereira L, Pinto L, Fernandes Redondo RA, Sestanovich B, Yeager M, Chanock S. 2013. Evolutionary dynamics of the human NADPH oxidase genes CYBB, CYBA, NCF2, and NCF4: Functional implications. Molecular Biology and Evolution. 30(9), 2157–2167.","ieee":"E. Tarazona Santos <i>et al.</i>, “Evolutionary dynamics of the human NADPH oxidase genes CYBB, CYBA, NCF2, and NCF4: Functional implications,” <i>Molecular Biology and Evolution</i>, vol. 30, no. 9. Oxford University Press, pp. 2157–2167, 2013.","chicago":"Tarazona Santos, Eduardo, Moara Machado, Wagner Magalhães, Renee Chen, Fernanda Lyon, Laurie Burdett, Andrew Crenshaw, et al. “Evolutionary Dynamics of the Human NADPH Oxidase Genes CYBB, CYBA, NCF2, and NCF4: Functional Implications.” <i>Molecular Biology and Evolution</i>. Oxford University Press, 2013. <a href=\"https://doi.org/10.1093/molbev/mst119\">https://doi.org/10.1093/molbev/mst119</a>.","apa":"Tarazona Santos, E., Machado, M., Magalhães, W., Chen, R., Lyon, F., Burdett, L., … Chanock, S. (2013). Evolutionary dynamics of the human NADPH oxidase genes CYBB, CYBA, NCF2, and NCF4: Functional implications. <i>Molecular Biology and Evolution</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/molbev/mst119\">https://doi.org/10.1093/molbev/mst119</a>"},"oa":1,"status":"public","external_id":{"pmid":["23821607"]},"issue":"9"},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"journal_article","volume":25,"page":"2986 - 2997","year":"2013","_id":"509","issue":"8","external_id":{"pmid":["23975899"]},"oa":1,"status":"public","citation":{"short":"S. Di Rubbo, N. Irani, S. Kim, Z. Xu, A. Gadeyne, W. Dejonghe, I. Vanhoutte, G. Persiau, D. Eeckhout, S. Simon, K. Song, J. Kleine Vehn, J. Friml, G. De Jaeger, D. Van Damme, I. Hwang, E. Russinova, Plant Cell 25 (2013) 2986–2997.","mla":"Di Rubbo, Simone, et al. “The Clathrin Adaptor Complex AP-2 Mediates Endocytosis of Brassinosteroid INSENSITIVE1 in Arabidopsis.” <i>Plant Cell</i>, vol. 25, no. 8, American Society of Plant Biologists, 2013, pp. 2986–97, doi:<a href=\"https://doi.org/10.1105/tpc.113.114058\">10.1105/tpc.113.114058</a>.","ista":"Di Rubbo S, Irani N, Kim S, Xu Z, Gadeyne A, Dejonghe W, Vanhoutte I, Persiau G, Eeckhout D, Simon S, Song K, Kleine Vehn J, Friml J, De Jaeger G, Van Damme D, Hwang I, Russinova E. 2013. The clathrin adaptor complex AP-2 mediates endocytosis of brassinosteroid INSENSITIVE1 in arabidopsis. Plant Cell. 25(8), 2986–2997.","ama":"Di Rubbo S, Irani N, Kim S, et al. The clathrin adaptor complex AP-2 mediates endocytosis of brassinosteroid INSENSITIVE1 in arabidopsis. <i>Plant Cell</i>. 2013;25(8):2986-2997. doi:<a href=\"https://doi.org/10.1105/tpc.113.114058\">10.1105/tpc.113.114058</a>","apa":"Di Rubbo, S., Irani, N., Kim, S., Xu, Z., Gadeyne, A., Dejonghe, W., … Russinova, E. (2013). The clathrin adaptor complex AP-2 mediates endocytosis of brassinosteroid INSENSITIVE1 in arabidopsis. <i>Plant Cell</i>. American Society of Plant Biologists. <a href=\"https://doi.org/10.1105/tpc.113.114058\">https://doi.org/10.1105/tpc.113.114058</a>","ieee":"S. Di Rubbo <i>et al.</i>, “The clathrin adaptor complex AP-2 mediates endocytosis of brassinosteroid INSENSITIVE1 in arabidopsis,” <i>Plant Cell</i>, vol. 25, no. 8. American Society of Plant Biologists, pp. 2986–2997, 2013.","chicago":"Di Rubbo, Simone, Niloufer Irani, Soo Kim, Zheng Xu, Astrid Gadeyne, Wim Dejonghe, Isabelle Vanhoutte, et al. “The Clathrin Adaptor Complex AP-2 Mediates Endocytosis of Brassinosteroid INSENSITIVE1 in Arabidopsis.” <i>Plant Cell</i>. American Society of Plant Biologists, 2013. <a href=\"https://doi.org/10.1105/tpc.113.114058\">https://doi.org/10.1105/tpc.113.114058</a>."},"publisher":"American Society of Plant Biologists","publication":"Plant Cell","department":[{"_id":"JiFr"}],"title":"The clathrin adaptor complex AP-2 mediates endocytosis of brassinosteroid INSENSITIVE1 in arabidopsis","publist_id":"7311","date_created":"2018-12-11T11:46:52Z","oa_version":"Submitted Version","abstract":[{"text":"Clathrin-mediated endocytosis (CME) regulates many aspects of plant development, including hormone signaling and responses to environmental stresses. Despite the importance of this process, the machinery that regulates CME in plants is largely unknown. In mammals, the heterotetrameric ADAPTOR PROTEIN COMPLEX-2 (AP-2) is required for the formation of clathrin-coated vesicles at the plasma membrane (PM). Although the existence of AP-2 has been predicted in Arabidopsis thaliana, the biochemistry and functionality of the complex is still uncharacterized. Here, we identified all the subunits of the Arabidopsis AP-2 by tandem affinity purification and found that one of the large AP-2 subunits, AP2A1, localized at the PM and interacted with clathrin. Furthermore, endocytosis of the leucine-rich repeat receptor kinase, BRASSINOSTEROID INSENSITIVE1 (BRI1), was shown to depend on AP-2. Knockdown of the two Arabidopsis AP2A genes or overexpression of a dominant-negative version of the medium AP-2 subunit, AP2M, impaired BRI1 endocytosis and enhanced the brassinosteroid signaling. Our data reveal that the CME machinery in Arabidopsis is evolutionarily conserved and that AP-2 functions in receptormediated endocytosis. ","lang":"eng"}],"publication_status":"published","intvolume":"        25","main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784593/"}],"day":"01","pmid":1,"month":"08","language":[{"iso":"eng"}],"doi":"10.1105/tpc.113.114058","date_updated":"2021-01-12T08:01:13Z","date_published":"2013-08-01T00:00:00Z","author":[{"last_name":"Di Rubbo","first_name":"Simone","full_name":"Di Rubbo, Simone"},{"last_name":"Irani","first_name":"Niloufer","full_name":"Irani, Niloufer"},{"full_name":"Kim, Soo","last_name":"Kim","first_name":"Soo"},{"full_name":"Xu, Zheng","first_name":"Zheng","last_name":"Xu"},{"full_name":"Gadeyne, Astrid","last_name":"Gadeyne","first_name":"Astrid"},{"full_name":"Dejonghe, Wim","first_name":"Wim","last_name":"Dejonghe"},{"first_name":"Isabelle","last_name":"Vanhoutte","full_name":"Vanhoutte, Isabelle"},{"first_name":"Geert","last_name":"Persiau","full_name":"Persiau, Geert"},{"first_name":"Dominique","last_name":"Eeckhout","full_name":"Eeckhout, Dominique"},{"first_name":"Sibu","orcid":"0000-0002-1998-6741","last_name":"Simon","full_name":"Simon, Sibu","id":"4542EF9A-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Kyungyoung","last_name":"Song","full_name":"Song, Kyungyoung"},{"last_name":"Kleine Vehn","first_name":"Jürgen","full_name":"Kleine Vehn, Jürgen"},{"last_name":"Friml","orcid":"0000-0002-8302-7596","first_name":"Jirí","id":"4159519E-F248-11E8-B48F-1D18A9856A87","full_name":"Friml, Jirí"},{"full_name":"De Jaeger, Geert","last_name":"De Jaeger","first_name":"Geert"},{"last_name":"Van Damme","first_name":"Daniël","full_name":"Van Damme, Daniël"},{"last_name":"Hwang","first_name":"Inhwan","full_name":"Hwang, Inhwan"},{"full_name":"Russinova, Eugenia","first_name":"Eugenia","last_name":"Russinova"}],"quality_controlled":"1","scopus_import":1},{"publication_status":"published","main_file_link":[{"open_access":"1","url":"www.doi.org/10.1105/tpc.113.114421"}],"intvolume":"        25","day":"01","pmid":1,"language":[{"iso":"eng"}],"month":"10","date_updated":"2021-01-12T08:01:15Z","doi":"10.1105/tpc.113.114421","author":[{"full_name":"Pěnčík, Aleš","first_name":"Aleš","last_name":"Pěnčík"},{"full_name":"Simonovik, Biljana","first_name":"Biljana","last_name":"Simonovik"},{"full_name":"Petersson, Sara","last_name":"Petersson","first_name":"Sara"},{"first_name":"Eva","last_name":"Henyková","full_name":"Henyková, Eva"},{"first_name":"Sibu","last_name":"Simon","orcid":"0000-0002-1998-6741","full_name":"Simon, Sibu","id":"4542EF9A-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Greenham, Kathleen","last_name":"Greenham","first_name":"Kathleen"},{"full_name":"Zhang, Yi","first_name":"Yi","last_name":"Zhang"},{"first_name":"Mariusz","last_name":"Kowalczyk","full_name":"Kowalczyk, Mariusz"},{"full_name":"Estelle, Mark","last_name":"Estelle","first_name":"Mark"},{"last_name":"Zažímalová","first_name":"Eva","full_name":"Zažímalová, Eva"},{"first_name":"Ondřej","last_name":"Novák","full_name":"Novák, Ondřej"},{"first_name":"Göran","last_name":"Sandberg","full_name":"Sandberg, Göran"},{"last_name":"Ljung","first_name":"Karin","full_name":"Ljung, Karin"}],"date_published":"2013-10-01T00:00:00Z","quality_controlled":"1","scopus_import":1,"type":"journal_article","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","page":"3858 - 3870","volume":25,"year":"2013","_id":"511","external_id":{"pmid":["24163311"]},"issue":"10","status":"public","oa":1,"citation":{"ista":"Pěnčík A, Simonovik B, Petersson S, Henyková E, Simon S, Greenham K, Zhang Y, Kowalczyk M, Estelle M, Zažímalová E, Novák O, Sandberg G, Ljung K. 2013. Regulation of auxin homeostasis and gradients in Arabidopsis roots through the formation of the indole-3-acetic acid catabolite 2-oxindole-3-acetic acid. Plant Cell. 25(10), 3858–3870.","mla":"Pěnčík, Aleš, et al. “Regulation of Auxin Homeostasis and Gradients in Arabidopsis Roots through the Formation of the Indole-3-Acetic Acid Catabolite 2-Oxindole-3-Acetic Acid.” <i>Plant Cell</i>, vol. 25, no. 10, American Society of Plant Biologists, 2013, pp. 3858–70, doi:<a href=\"https://doi.org/10.1105/tpc.113.114421\">10.1105/tpc.113.114421</a>.","short":"A. Pěnčík, B. Simonovik, S. Petersson, E. Henyková, S. Simon, K. Greenham, Y. Zhang, M. Kowalczyk, M. Estelle, E. Zažímalová, O. Novák, G. Sandberg, K. Ljung, Plant Cell 25 (2013) 3858–3870.","ama":"Pěnčík A, Simonovik B, Petersson S, et al. Regulation of auxin homeostasis and gradients in Arabidopsis roots through the formation of the indole-3-acetic acid catabolite 2-oxindole-3-acetic acid. <i>Plant Cell</i>. 2013;25(10):3858-3870. doi:<a href=\"https://doi.org/10.1105/tpc.113.114421\">10.1105/tpc.113.114421</a>","apa":"Pěnčík, A., Simonovik, B., Petersson, S., Henyková, E., Simon, S., Greenham, K., … Ljung, K. (2013). Regulation of auxin homeostasis and gradients in Arabidopsis roots through the formation of the indole-3-acetic acid catabolite 2-oxindole-3-acetic acid. <i>Plant Cell</i>. American Society of Plant Biologists. <a href=\"https://doi.org/10.1105/tpc.113.114421\">https://doi.org/10.1105/tpc.113.114421</a>","ieee":"A. Pěnčík <i>et al.</i>, “Regulation of auxin homeostasis and gradients in Arabidopsis roots through the formation of the indole-3-acetic acid catabolite 2-oxindole-3-acetic acid,” <i>Plant Cell</i>, vol. 25, no. 10. American Society of Plant Biologists, pp. 3858–3870, 2013.","chicago":"Pěnčík, Aleš, Biljana Simonovik, Sara Petersson, Eva Henyková, Sibu Simon, Kathleen Greenham, Yi Zhang, et al. “Regulation of Auxin Homeostasis and Gradients in Arabidopsis Roots through the Formation of the Indole-3-Acetic Acid Catabolite 2-Oxindole-3-Acetic Acid.” <i>Plant Cell</i>. American Society of Plant Biologists, 2013. <a href=\"https://doi.org/10.1105/tpc.113.114421\">https://doi.org/10.1105/tpc.113.114421</a>."},"publisher":"American Society of Plant Biologists","department":[{"_id":"JiFr"}],"title":"Regulation of auxin homeostasis and gradients in Arabidopsis roots through the formation of the indole-3-acetic acid catabolite 2-oxindole-3-acetic acid","publication":"Plant Cell","publist_id":"7309","oa_version":"Published Version","date_created":"2018-12-11T11:46:53Z","abstract":[{"lang":"eng","text":"The native auxin, indole-3-acetic acid (IAA), is a major regulator of plant growth and development. Its nonuniform distribution between cells and tissues underlies the spatiotemporal coordination of many developmental events and responses to environmental stimuli. The regulation of auxin gradients and the formation of auxin maxima/minima most likely involve the regulation of both metabolic and transport processes. In this article, we have demonstrated that 2-oxindole-3-acetic acid (oxIAA) is a major primary IAA catabolite formed in Arabidopsis thaliana root tissues. OxIAA had little biological activity and was formed rapidly and irreversibly in response to increases in auxin levels. We further showed that there is cell type-specific regulation of oxIAA levels in the Arabidopsis root apex. We propose that oxIAA is an important element in the regulation of output from auxin gradients and, therefore, in the regulation of auxin homeostasis and response mechanisms."}]}]