[{"scopus_import":1,"article_processing_charge":"No","department":[{"_id":"ToHe"}],"publisher":"Springer","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publist_id":"4456","title":"Automating separation logic using SMT","day":"01","file":[{"creator":"dernst","file_size":309182,"content_type":"application/pdf","relation":"main_file","file_name":"2013_CAV_Piskac.pdf","access_level":"open_access","date_created":"2020-05-15T11:13:01Z","checksum":"2e866932ab688f47ecd504acb4d5c7d4","file_id":"7859","date_updated":"2020-07-14T12:45:41Z"}],"author":[{"full_name":"Piskac, Ruzica","last_name":"Piskac","first_name":"Ruzica"},{"id":"447BFB88-F248-11E8-B48F-1D18A9856A87","full_name":"Wies, Thomas","first_name":"Thomas","last_name":"Wies"},{"full_name":"Zufferey, Damien","id":"4397AC76-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-3197-8736","first_name":"Damien","last_name":"Zufferey"}],"language":[{"iso":"eng"}],"conference":{"start_date":"2013-07-13","location":"St. Petersburg, Russia","name":"CAV: Computer Aided Verification","end_date":"2013-07-19"},"series_title":"Lecture Notes in Computer Science","quality_controlled":"1","doi":"10.1007/978-3-642-39799-8_54","_id":"2447","year":"2013","date_created":"2018-12-11T11:57:43Z","file_date_updated":"2020-07-14T12:45:41Z","volume":8044,"type":"conference","oa_version":"Submitted Version","month":"07","abstract":[{"text":"Separation logic (SL) has gained widespread popularity because of its ability to succinctly express complex invariants of a program’s heap configurations. Several specialized provers have been developed for decidable SL fragments. However, these provers cannot be easily extended or combined with solvers for other theories that are important in program verification, e.g., linear arithmetic. In this paper, we present a reduction of decidable SL fragments to a decidable first-order theory that fits well into the satisfiability modulo theories (SMT) framework. We show how to use this reduction to automate satisfiability, entailment, frame inference, and abduction problems for separation logic using SMT solvers. Our approach provides a simple method of integrating separation logic into existing verification tools that provide SMT backends, and an elegant way of combining SL fragments with other decidable first-order theories. We implemented this approach in a verification tool and applied it to heap-manipulating programs whose verification involves reasoning in theory combinations.\r\n","lang":"eng"}],"date_updated":"2020-08-11T10:09:47Z","page":"773 - 789","citation":{"ama":"Piskac R, Wies T, Zufferey D. Automating separation logic using SMT. 2013;8044:773-789. doi:<a href=\"https://doi.org/10.1007/978-3-642-39799-8_54\">10.1007/978-3-642-39799-8_54</a>","apa":"Piskac, R., Wies, T., &#38; Zufferey, D. (2013). Automating separation logic using SMT. Presented at the CAV: Computer Aided Verification, St. Petersburg, Russia: Springer. <a href=\"https://doi.org/10.1007/978-3-642-39799-8_54\">https://doi.org/10.1007/978-3-642-39799-8_54</a>","mla":"Piskac, Ruzica, et al. <i>Automating Separation Logic Using SMT</i>. Vol. 8044, Springer, 2013, pp. 773–89, doi:<a href=\"https://doi.org/10.1007/978-3-642-39799-8_54\">10.1007/978-3-642-39799-8_54</a>.","ista":"Piskac R, Wies T, Zufferey D. 2013. Automating separation logic using SMT. 8044, 773–789.","chicago":"Piskac, Ruzica, Thomas Wies, and Damien Zufferey. “Automating Separation Logic Using SMT.” Lecture Notes in Computer Science. Springer, 2013. <a href=\"https://doi.org/10.1007/978-3-642-39799-8_54\">https://doi.org/10.1007/978-3-642-39799-8_54</a>.","ieee":"R. Piskac, T. Wies, and D. Zufferey, “Automating separation logic using SMT,” vol. 8044. Springer, pp. 773–789, 2013.","short":"R. Piskac, T. Wies, D. Zufferey, 8044 (2013) 773–789."},"intvolume":"      8044","status":"public","alternative_title":["LNCS"],"date_published":"2013-07-01T00:00:00Z","ddc":["000"],"has_accepted_license":"1","oa":1,"publication_status":"published"},{"publication_status":"published","oa":1,"main_file_link":[{"url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091088/","open_access":"1"}],"date_published":"2013-07-10T00:00:00Z","external_id":{"pmid":["23857365"]},"status":"public","citation":{"ama":"Remy E, Baster P, Friml J, Duque P. ZIFL1.1 transporter modulates polar auxin transport by stabilizing membrane abundance of multiple PINs in Arabidopsis root tip. <i>Plant Signaling &#38; Behavior</i>. 2013;8(10). doi:<a href=\"https://doi.org/10.4161/psb.25688\">10.4161/psb.25688</a>","mla":"Remy, Estelle, et al. “ZIFL1.1 Transporter Modulates Polar Auxin Transport by Stabilizing Membrane Abundance of Multiple PINs in Arabidopsis Root Tip.” <i>Plant Signaling &#38; Behavior</i>, vol. 8, no. 10, e25688, Taylor &#38; Francis, 2013, doi:<a href=\"https://doi.org/10.4161/psb.25688\">10.4161/psb.25688</a>.","ista":"Remy E, Baster P, Friml J, Duque P. 2013. ZIFL1.1 transporter modulates polar auxin transport by stabilizing membrane abundance of multiple PINs in Arabidopsis root tip. Plant Signaling &#38; Behavior. 8(10), e25688.","apa":"Remy, E., Baster, P., Friml, J., &#38; Duque, P. (2013). ZIFL1.1 transporter modulates polar auxin transport by stabilizing membrane abundance of multiple PINs in Arabidopsis root tip. <i>Plant Signaling &#38; Behavior</i>. Taylor &#38; Francis. <a href=\"https://doi.org/10.4161/psb.25688\">https://doi.org/10.4161/psb.25688</a>","ieee":"E. Remy, P. Baster, J. Friml, and P. Duque, “ZIFL1.1 transporter modulates polar auxin transport by stabilizing membrane abundance of multiple PINs in Arabidopsis root tip,” <i>Plant Signaling &#38; Behavior</i>, vol. 8, no. 10. Taylor &#38; Francis, 2013.","chicago":"Remy, Estelle, Pawel Baster, Jiří Friml, and Paula Duque. “ZIFL1.1 Transporter Modulates Polar Auxin Transport by Stabilizing Membrane Abundance of Multiple PINs in Arabidopsis Root Tip.” <i>Plant Signaling &#38; Behavior</i>. Taylor &#38; Francis, 2013. <a href=\"https://doi.org/10.4161/psb.25688\">https://doi.org/10.4161/psb.25688</a>.","short":"E. Remy, P. Baster, J. Friml, P. Duque, Plant Signaling &#38; Behavior 8 (2013)."},"intvolume":"         8","abstract":[{"text":"Cell-to-cell directional flow of the phytohormone auxin is primarily established by polar localization of the PIN auxin transporters, a process tightly regulated at multiple levels by auxin itself. We recently reported that, in the context of strong auxin flows, activity of the vacuolar ZIFL1.1 transporter is required for fine-tuning of polar auxin transport rates in the Arabidopsis root. In particular, ZIFL1.1 function protects plasma-membrane stability of the PIN2 carrier in epidermal root tip cells under conditions normally triggering PIN2 degradation. Here, we show that ZIFL1.1 activity at the root tip also promotes PIN1 plasma-membrane abundance in central cylinder cells, thus supporting the notion that ZIFL1.1 acts as a general positive modulator of polar auxin transport in roots.","lang":"eng"}],"date_updated":"2025-05-07T11:12:32Z","type":"journal_article","oa_version":"Submitted Version","month":"07","date_created":"2018-12-11T11:57:43Z","volume":8,"year":"2013","_id":"2448","quality_controlled":"1","doi":"10.4161/psb.25688","project":[{"grant_number":"282300","name":"Polarity and subcellular dynamics in plants","call_identifier":"FP7","_id":"25716A02-B435-11E9-9278-68D0E5697425"}],"language":[{"iso":"eng"}],"issue":"10","day":"10","author":[{"first_name":"Estelle","last_name":"Remy","full_name":"Remy, Estelle"},{"id":"3028BD74-F248-11E8-B48F-1D18A9856A87","full_name":"Baster, Pawel","first_name":"Pawel","last_name":"Baster"},{"full_name":"Friml, Jirí","orcid":"0000-0002-8302-7596","id":"4159519E-F248-11E8-B48F-1D18A9856A87","first_name":"Jirí","last_name":"Friml"},{"full_name":"Duque, Paula","first_name":"Paula","last_name":"Duque"}],"publist_id":"4455","title":"ZIFL1.1 transporter modulates polar auxin transport by stabilizing membrane abundance of multiple PINs in Arabidopsis root tip","article_number":"e25688","pmid":1,"department":[{"_id":"JiFr"}],"publisher":"Taylor & Francis","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","scopus_import":"1","ec_funded":1,"article_processing_charge":"No","article_type":"original","publication":"Plant Signaling & Behavior"},{"status":"public","intvolume":"         6","citation":{"ama":"Nodzyński T, Feraru M, Hirsch S, et al. Retromer subunits VPS35A and VPS29 mediate prevacuolar compartment (PVC) function in Arabidopsis. <i>Molecular Plant</i>. 2013;6(6):1849-1862. doi:<a href=\"https://doi.org/10.1093/mp/sst044\">10.1093/mp/sst044</a>","apa":"Nodzyński, T., Feraru, M., Hirsch, S., De Rycke, R., Nicuales, C., Van Leene, J., … Friml, J. (2013). Retromer subunits VPS35A and VPS29 mediate prevacuolar compartment (PVC) function in Arabidopsis. <i>Molecular Plant</i>. Cell Press. <a href=\"https://doi.org/10.1093/mp/sst044\">https://doi.org/10.1093/mp/sst044</a>","ista":"Nodzyński T, Feraru M, Hirsch S, De Rycke R, Nicuales C, Van Leene J, De Jaeger G, Vanneste S, Friml J. 2013. Retromer subunits VPS35A and VPS29 mediate prevacuolar compartment (PVC) function in Arabidopsis. Molecular Plant. 6(6), 1849–1862.","mla":"Nodzyński, Tomasz, et al. “Retromer Subunits VPS35A and VPS29 Mediate Prevacuolar Compartment (PVC) Function in Arabidopsis.” <i>Molecular Plant</i>, vol. 6, no. 6, Cell Press, 2013, pp. 1849–62, doi:<a href=\"https://doi.org/10.1093/mp/sst044\">10.1093/mp/sst044</a>.","chicago":"Nodzyński, Tomasz, Murguel Feraru, Sibylle Hirsch, Riet De Rycke, Claudiu Nicuales, Jelle Van Leene, Geert De Jaeger, Steffen Vanneste, and Jiří Friml. “Retromer Subunits VPS35A and VPS29 Mediate Prevacuolar Compartment (PVC) Function in Arabidopsis.” <i>Molecular Plant</i>. Cell Press, 2013. <a href=\"https://doi.org/10.1093/mp/sst044\">https://doi.org/10.1093/mp/sst044</a>.","ieee":"T. Nodzyński <i>et al.</i>, “Retromer subunits VPS35A and VPS29 mediate prevacuolar compartment (PVC) function in Arabidopsis,” <i>Molecular Plant</i>, vol. 6, no. 6. Cell Press, pp. 1849–1862, 2013.","short":"T. Nodzyński, M. Feraru, S. Hirsch, R. De Rycke, C. Nicuales, J. Van Leene, G. De Jaeger, S. Vanneste, J. Friml, Molecular Plant 6 (2013) 1849–1862."},"language":[{"iso":"eng"}],"issue":"6","publication_status":"published","doi":"10.1093/mp/sst044","date_published":"2013-11-01T00:00:00Z","quality_controlled":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"Cell Press","year":"2013","department":[{"_id":"JiFr"}],"publication":"Molecular Plant","_id":"2449","scopus_import":1,"author":[{"first_name":"Tomasz","last_name":"Nodzyński","full_name":"Nodzyński, Tomasz"},{"full_name":"Feraru, Murguel","last_name":"Feraru","first_name":"Murguel"},{"first_name":"Sibylle","last_name":"Hirsch","full_name":"Hirsch, Sibylle"},{"first_name":"Riet","last_name":"De Rycke","full_name":"De Rycke, Riet"},{"full_name":"Nicuales, Claudiu","last_name":"Nicuales","first_name":"Claudiu"},{"full_name":"Van Leene, Jelle","last_name":"Van Leene","first_name":"Jelle"},{"first_name":"Geert","last_name":"De Jaeger","full_name":"De Jaeger, Geert"},{"full_name":"Vanneste, Steffen","first_name":"Steffen","last_name":"Vanneste"},{"orcid":"0000-0002-8302-7596","id":"4159519E-F248-11E8-B48F-1D18A9856A87","full_name":"Friml, Jirí","last_name":"Friml","first_name":"Jirí"}],"page":"1849 - 1862","abstract":[{"text":"Intracellular protein routing is mediated by vesicular transport which is tightly regulated in eukaryotes. The protein and lipid homeostasis depends on coordinated delivery of de novo synthesized or recycled cargoes to the plasma membrane by exocytosis and their subsequent removal by rerouting them for recycling or degradation. Here, we report the characterization of protein affected trafficking 3 (pat3) mutant that we identified by an epifluorescence-based forward genetic screen for mutants defective in subcellular distribution of Arabidopsis auxin transporter PIN1–GFP. While pat3 displays largely normal plant morphology and development in nutrient-rich conditions, it shows strong ectopic intracellular accumulations of different plasma membrane cargoes in structures that resemble prevacuolar compartments (PVC) with an aberrant morphology. Genetic mapping revealed that pat3 is defective in vacuolar protein sorting 35A (VPS35A), a putative subunit of the retromer complex that mediates retrograde trafficking between the PVC and trans-Golgi network. Similarly, a mutant defective in another retromer subunit, vps29, shows comparable subcellular defects in PVC morphology and protein accumulation. Thus, our data provide evidence that the retromer components VPS35A and VPS29 are essential for normal PVC morphology and normal trafficking of plasma membrane proteins in plants. In addition, we show that, out of the three VPS35 retromer subunits present in Arabidopsis thaliana genome, the VPS35 homolog A plays a prevailing role in trafficking to the lytic vacuole, presenting another level of complexity in the retromer-dependent vacuolar sorting. ","lang":"eng"}],"date_updated":"2021-01-12T06:57:33Z","day":"01","oa_version":"None","month":"11","type":"journal_article","title":"Retromer subunits VPS35A and VPS29 mediate prevacuolar compartment (PVC) function in Arabidopsis","volume":6,"publist_id":"4454","date_created":"2018-12-11T11:57:44Z"},{"status":"public","issue":"680","citation":{"mla":"Baier, Stephan, and Timothy D. Browning. “Inhomogeneous Cubic Congruences and Rational Points on Del Pezzo Surfaces.” <i>Journal Fur Die Reine Und Angewandte Mathematik</i>, no. 680, Walter de Gruyter, 2013, pp. 69–151, doi:<a href=\"https://doi.org/10.1515/crelle.2012.039\">10.1515/crelle.2012.039</a>.","ista":"Baier S, Browning TD. 2013. Inhomogeneous cubic congruences and rational points on del Pezzo surfaces. Journal fur die Reine und Angewandte Mathematik. (680), 69–151.","apa":"Baier, S., &#38; Browning, T. D. (2013). Inhomogeneous cubic congruences and rational points on del Pezzo surfaces. <i>Journal Fur Die Reine Und Angewandte Mathematik</i>. Walter de Gruyter. <a href=\"https://doi.org/10.1515/crelle.2012.039\">https://doi.org/10.1515/crelle.2012.039</a>","ama":"Baier S, Browning TD. Inhomogeneous cubic congruences and rational points on del Pezzo surfaces. <i>Journal fur die Reine und Angewandte Mathematik</i>. 2013;(680):69-151. doi:<a href=\"https://doi.org/10.1515/crelle.2012.039\">10.1515/crelle.2012.039</a>","short":"S. Baier, T.D. Browning, Journal Fur Die Reine Und Angewandte Mathematik (2013) 69–151.","ieee":"S. Baier and T. D. Browning, “Inhomogeneous cubic congruences and rational points on del Pezzo surfaces,” <i>Journal fur die Reine und Angewandte Mathematik</i>, no. 680. Walter de Gruyter, pp. 69–151, 2013.","chicago":"Baier, Stephan, and Timothy D Browning. “Inhomogeneous Cubic Congruences and Rational Points on Del Pezzo Surfaces.” <i>Journal Fur Die Reine Und Angewandte Mathematik</i>. Walter de Gruyter, 2013. <a href=\"https://doi.org/10.1515/crelle.2012.039\">https://doi.org/10.1515/crelle.2012.039</a>."},"extern":1,"oa":1,"publication_status":"published","quality_controlled":0,"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1011.3434"}],"date_published":"2013-07-01T00:00:00Z","doi":"10.1515/crelle.2012.039","year":"2013","publisher":"Walter de Gruyter","_id":"245","publication":"Journal fur die Reine und Angewandte Mathematik","month":"07","type":"journal_article","abstract":[{"lang":"eng","text":"For given non-zero integers a, b, q we investigate the density of solutions (x; y) ∈ ℤ2 to the binary cubic congruence ax2 + by3 ≡ 0 mod q, and use it to establish the Manin conjecture for a singular del Pezzo surface of degree 2 defined over ℚ."}],"day":"01","date_updated":"2021-01-12T06:57:33Z","author":[{"full_name":"Baier, Stephan","last_name":"Baier","first_name":"Stephan"},{"last_name":"Browning","first_name":"Timothy D","orcid":"0000-0002-8314-0177","id":"35827D50-F248-11E8-B48F-1D18A9856A87","full_name":"Timothy Browning"}],"page":"69 - 151","publist_id":"7659","date_created":"2018-12-11T11:45:24Z","title":"Inhomogeneous cubic congruences and rational points on del Pezzo surfaces"},{"status":"public","citation":{"ama":"Liu J, Menhi S, Topping J, Friml J, Lindsey K. Interaction of PLS and PIN and hormonal crosstalk in Arabidopsis root development. <i>Frontiers in Plant Science</i>. 2013;4(75). doi:<a href=\"https://doi.org/10.3389/fpls.2013.00075\">10.3389/fpls.2013.00075</a>","ista":"Liu J, Menhi S, Topping J, Friml J, Lindsey K. 2013. Interaction of PLS and PIN and hormonal crosstalk in Arabidopsis root development. Frontiers in Plant Science. 4(75).","mla":"Liu, Junli, et al. “Interaction of PLS and PIN and Hormonal Crosstalk in Arabidopsis Root Development.” <i>Frontiers in Plant Science</i>, vol. 4, no. 75, Frontiers Research Foundation, 2013, doi:<a href=\"https://doi.org/10.3389/fpls.2013.00075\">10.3389/fpls.2013.00075</a>.","apa":"Liu, J., Menhi, S., Topping, J., Friml, J., &#38; Lindsey, K. (2013). Interaction of PLS and PIN and hormonal crosstalk in Arabidopsis root development. <i>Frontiers in Plant Science</i>. Frontiers Research Foundation. <a href=\"https://doi.org/10.3389/fpls.2013.00075\">https://doi.org/10.3389/fpls.2013.00075</a>","ieee":"J. Liu, S. Menhi, J. Topping, J. Friml, and K. Lindsey, “Interaction of PLS and PIN and hormonal crosstalk in Arabidopsis root development,” <i>Frontiers in Plant Science</i>, vol. 4, no. 75. Frontiers Research Foundation, 2013.","chicago":"Liu, Junli, Saher Menhi, Jennifer Topping, Jiří Friml, and Keith Lindsey. “Interaction of PLS and PIN and Hormonal Crosstalk in Arabidopsis Root Development.” <i>Frontiers in Plant Science</i>. Frontiers Research Foundation, 2013. <a href=\"https://doi.org/10.3389/fpls.2013.00075\">https://doi.org/10.3389/fpls.2013.00075</a>.","short":"J. Liu, S. Menhi, J. Topping, J. Friml, K. Lindsey, Frontiers in Plant Science 4 (2013)."},"issue":"75","intvolume":"         4","extern":1,"publication_status":"published","quality_controlled":0,"doi":"10.3389/fpls.2013.00075","date_published":"2013-04-01T00:00:00Z","year":"2013","publisher":"Frontiers Research Foundation","publication":"Frontiers in Plant Science","_id":"2450","date_updated":"2021-01-12T06:57:34Z","abstract":[{"lang":"eng","text":"Understanding how hormones and genes interact to coordinate plant growth is a major challenge in developmental biology. The activities of auxin, ethylene, and cytokinin depend on cellular context and exhibit either synergistic or antagonistic interactions. Here we use experimentation and network construction to elucidate the role of the interaction of the POLARIS peptide (PLS) and the auxin efflux carrier PIN proteins in the crosstalk of three hormones (auxin, ethylene, and cytokinin) in Arabidopsis root development. In ethylene hypersignaling mutants such as polaris (pls), we show experimentally that expression of both PIN1 and PIN2 significantly increases. This relationship is analyzed in the context of the crosstalk between auxin, ethylene, and cytokinin: in pls, endogenous auxin, ethylene and cytokinin concentration decreases, approximately remains unchanged and increases, respectively. Experimental data are integrated into a hormonal crosstalk network through combination with information in literature. Network construction reveals that the regulation of both PIN1 and PIN2 is predominantly via ethylene signaling. In addition, it is deduced that the relationship between cytokinin and PIN1 and PIN2 levels implies a regulatory role of cytokinin in addition to its regulation to auxin, ethylene, and PLS levels. We discuss how the network of hormones and genes coordinates plant growth by simultaneously regulating the activities of auxin, ethylene, and cytokinin signaling pathways.hormonal crosstalk, root development, auxin flux, PIN proteins, PLS protein, signaling network"}],"day":"01","type":"journal_article","month":"04","author":[{"first_name":"Junli","last_name":"Liu","full_name":"Liu, Junli"},{"first_name":"Saher","last_name":"Menhi","full_name":"Menhi, Saher"},{"last_name":"Topping","first_name":"Jennifer","full_name":"Topping, Jennifer"},{"full_name":"Jirí Friml","orcid":"0000-0002-8302-7596","id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml","first_name":"Jirí"},{"full_name":"Lindsey, Keith","last_name":"Lindsey","first_name":"Keith"}],"publist_id":"4453","date_created":"2018-12-11T11:57:44Z","volume":4,"title":"Interaction of PLS and PIN and hormonal crosstalk in Arabidopsis root development"},{"title":"Single-cell-based system to monitor carrier driven cellular auxin homeostasis","volume":13,"publist_id":"4451","date_created":"2018-12-11T11:57:45Z","author":[{"first_name":"Elke","last_name":"Barbez","full_name":"Barbez, Elke"},{"full_name":"Laňková, Martina","first_name":"Martina","last_name":"Laňková"},{"first_name":"Markéta","last_name":"Pařezová","full_name":"Pařezová, Markéta"},{"first_name":"Alexis","last_name":"Maizel","full_name":"Maizel, Alexis"},{"full_name":"Zažímalová, Eva","last_name":"Zažímalová","first_name":"Eva"},{"full_name":"Petrášek, Jan","first_name":"Jan","last_name":"Petrášek"},{"first_name":"Jirí","last_name":"Friml","id":"4159519E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8302-7596","full_name":"Jirí Friml"},{"full_name":"Kleine-Vehn, Jürgen","last_name":"Kleine Vehn","first_name":"Jürgen"}],"type":"journal_article","month":"02","day":"01","date_updated":"2021-01-12T06:57:34Z","abstract":[{"text":"Background: Abundance and distribution of the plant hormone auxin play important roles in plant development. Besides other metabolic processes, various auxin carriers control the cellular level of active auxin and, hence, are major regulators of cellular auxin homeostasis. Despite the developmental importance of auxin transporters, a simple medium-to-high throughput approach to assess carrier activities is still missing. Here we show that carrier driven depletion of cellular auxin correlates with reduced nuclear auxin signaling in tobacco Bright Yellow-2 (BY-2) cell cultures.Results: We developed an easy to use transient single-cell-based system to detect carrier activity. We use the relative changes in signaling output of the auxin responsive promoter element DR5 to indirectly visualize auxin carrier activity. The feasibility of the transient approach was demonstrated by pharmacological and genetic interference with auxin signaling and transport. As a proof of concept, we provide visual evidence that the prominent auxin transport proteins PIN-FORMED (PIN)2 and PIN5 regulate cellular auxin homeostasis at the plasma membrane and endoplasmic reticulum (ER), respectively. Our data suggest that PIN2 and PIN5 have different sensitivities to the auxin transport inhibitor 1-naphthylphthalamic acid (NPA). Also the putative PIN-LIKES (PILS) auxin carrier activity at the ER is insensitive to NPA in our system, indicating that NPA blocks intercellular, but not intracellular auxin transport.Conclusions: This single-cell-based system is a useful tool by which the activity of putative auxin carriers, such as PINs, PILS and WALLS ARE THIN1 (WAT1), can be indirectly visualized in a medium-to-high throughput manner. Moreover, our single cell system might be useful to investigate also other hormonal signaling pathways, such as cytokinin.","lang":"eng"}],"_id":"2452","publication":"BMC Plant Biology","publisher":"BioMed Central","year":"2013","date_published":"2013-02-01T00:00:00Z","doi":"10.1186/1471-2229-13-20","quality_controlled":0,"publication_status":"published","extern":1,"intvolume":"        13","issue":"1","citation":{"apa":"Barbez, E., Laňková, M., Pařezová, M., Maizel, A., Zažímalová, E., Petrášek, J., … Kleine Vehn, J. (2013). Single-cell-based system to monitor carrier driven cellular auxin homeostasis. <i>BMC Plant Biology</i>. BioMed Central. <a href=\"https://doi.org/10.1186/1471-2229-13-20\">https://doi.org/10.1186/1471-2229-13-20</a>","mla":"Barbez, Elke, et al. “Single-Cell-Based System to Monitor Carrier Driven Cellular Auxin Homeostasis.” <i>BMC Plant Biology</i>, vol. 13, no. 1, BioMed Central, 2013, doi:<a href=\"https://doi.org/10.1186/1471-2229-13-20\">10.1186/1471-2229-13-20</a>.","ista":"Barbez E, Laňková M, Pařezová M, Maizel A, Zažímalová E, Petrášek J, Friml J, Kleine Vehn J. 2013. Single-cell-based system to monitor carrier driven cellular auxin homeostasis. BMC Plant Biology. 13(1).","ama":"Barbez E, Laňková M, Pařezová M, et al. Single-cell-based system to monitor carrier driven cellular auxin homeostasis. <i>BMC Plant Biology</i>. 2013;13(1). doi:<a href=\"https://doi.org/10.1186/1471-2229-13-20\">10.1186/1471-2229-13-20</a>","short":"E. Barbez, M. Laňková, M. Pařezová, A. Maizel, E. Zažímalová, J. Petrášek, J. Friml, J. Kleine Vehn, BMC Plant Biology 13 (2013).","chicago":"Barbez, Elke, Martina Laňková, Markéta Pařezová, Alexis Maizel, Eva Zažímalová, Jan Petrášek, Jiří Friml, and Jürgen Kleine Vehn. “Single-Cell-Based System to Monitor Carrier Driven Cellular Auxin Homeostasis.” <i>BMC Plant Biology</i>. BioMed Central, 2013. <a href=\"https://doi.org/10.1186/1471-2229-13-20\">https://doi.org/10.1186/1471-2229-13-20</a>.","ieee":"E. Barbez <i>et al.</i>, “Single-cell-based system to monitor carrier driven cellular auxin homeostasis,” <i>BMC Plant Biology</i>, vol. 13, no. 1. BioMed Central, 2013."},"status":"public"},{"date_published":"2013-01-01T00:00:00Z","doi":"10.1016/j.tplants.2012.08.009","quality_controlled":"1","publication_status":"published","intvolume":"        18","extern":"1","issue":"1","citation":{"ama":"Viaene T, Delwiche C, Rensing S, Friml J. Origin and evolution of PIN auxin transporters in the green lineage. <i>Trends in Plant Science</i>. 2013;18(1):5-10. doi:<a href=\"https://doi.org/10.1016/j.tplants.2012.08.009\">10.1016/j.tplants.2012.08.009</a>","apa":"Viaene, T., Delwiche, C., Rensing, S., &#38; Friml, J. (2013). Origin and evolution of PIN auxin transporters in the green lineage. <i>Trends in Plant Science</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.tplants.2012.08.009\">https://doi.org/10.1016/j.tplants.2012.08.009</a>","mla":"Viaene, Tom, et al. “Origin and Evolution of PIN Auxin Transporters in the Green Lineage.” <i>Trends in Plant Science</i>, vol. 18, no. 1, Cell Press, 2013, pp. 5–10, doi:<a href=\"https://doi.org/10.1016/j.tplants.2012.08.009\">10.1016/j.tplants.2012.08.009</a>.","ista":"Viaene T, Delwiche C, Rensing S, Friml J. 2013. Origin and evolution of PIN auxin transporters in the green lineage. Trends in Plant Science. 18(1), 5–10.","chicago":"Viaene, Tom, Charles Delwiche, Stefan Rensing, and Jiří Friml. “Origin and Evolution of PIN Auxin Transporters in the Green Lineage.” <i>Trends in Plant Science</i>. Cell Press, 2013. <a href=\"https://doi.org/10.1016/j.tplants.2012.08.009\">https://doi.org/10.1016/j.tplants.2012.08.009</a>.","ieee":"T. Viaene, C. Delwiche, S. Rensing, and J. Friml, “Origin and evolution of PIN auxin transporters in the green lineage,” <i>Trends in Plant Science</i>, vol. 18, no. 1. Cell Press, pp. 5–10, 2013.","short":"T. Viaene, C. Delwiche, S. Rensing, J. Friml, Trends in Plant Science 18 (2013) 5–10."},"language":[{"iso":"eng"}],"status":"public","volume":18,"title":"Origin and evolution of PIN auxin transporters in the green lineage","publist_id":"4446","date_created":"2018-12-11T11:57:46Z","page":"5 - 10","author":[{"full_name":"Viaene, Tom","first_name":"Tom","last_name":"Viaene"},{"full_name":"Delwiche, Charles","first_name":"Charles","last_name":"Delwiche"},{"first_name":"Stefan","last_name":"Rensing","full_name":"Rensing, Stefan"},{"last_name":"Friml","first_name":"Jirí","full_name":"Friml, Jirí","id":"4159519E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8302-7596"}],"type":"journal_article","oa_version":"None","month":"01","date_updated":"2021-01-12T06:57:36Z","day":"01","_id":"2457","publication":"Trends in Plant Science","publisher":"Cell Press","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","year":"2013"},{"date_created":"2018-12-11T11:45:25Z","publist_id":"7658","title":"Rational points on singular intersections of quadrics","volume":149,"day":"01","date_updated":"2021-01-12T06:57:37Z","abstract":[{"lang":"eng","text":"Given an intersection of two quadrics X Pm1, with m &gt; 9, the quantitative arithmetic of the set X(Q) is investigated under the assumption that the singular locus of X consists of a pair of conjugate singular points defined over Q(i)."}],"type":"journal_article","month":"09","page":"1457 - 1494","author":[{"last_name":"Browning","first_name":"Timothy D","full_name":"Timothy Browning","id":"35827D50-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8314-0177"},{"full_name":"Munshi, Ritabrata","first_name":"Ritabrata","last_name":"Munshi"}],"publication":"Compositio Mathematica","_id":"246","year":"2013","publisher":"Cambridge University Press","acknowledgement":"EP/E053262/1\tEngineering and Physical Sciences Research Council","quality_controlled":0,"date_published":"2013-09-01T00:00:00Z","doi":"10.1112/S0010437X13007185","publication_status":"published","citation":{"apa":"Browning, T. D., &#38; Munshi, R. (2013). Rational points on singular intersections of quadrics. <i>Compositio Mathematica</i>. Cambridge University Press. <a href=\"https://doi.org/10.1112/S0010437X13007185\">https://doi.org/10.1112/S0010437X13007185</a>","mla":"Browning, Timothy D., and Ritabrata Munshi. “Rational Points on Singular Intersections of Quadrics.” <i>Compositio Mathematica</i>, vol. 149, no. 9, Cambridge University Press, 2013, pp. 1457–94, doi:<a href=\"https://doi.org/10.1112/S0010437X13007185\">10.1112/S0010437X13007185</a>.","ista":"Browning TD, Munshi R. 2013. Rational points on singular intersections of quadrics. Compositio Mathematica. 149(9), 1457–1494.","ama":"Browning TD, Munshi R. Rational points on singular intersections of quadrics. <i>Compositio Mathematica</i>. 2013;149(9):1457-1494. doi:<a href=\"https://doi.org/10.1112/S0010437X13007185\">10.1112/S0010437X13007185</a>","short":"T.D. Browning, R. Munshi, Compositio Mathematica 149 (2013) 1457–1494.","chicago":"Browning, Timothy D, and Ritabrata Munshi. “Rational Points on Singular Intersections of Quadrics.” <i>Compositio Mathematica</i>. Cambridge University Press, 2013. <a href=\"https://doi.org/10.1112/S0010437X13007185\">https://doi.org/10.1112/S0010437X13007185</a>.","ieee":"T. D. Browning and R. Munshi, “Rational points on singular intersections of quadrics,” <i>Compositio Mathematica</i>, vol. 149, no. 9. Cambridge University Press, pp. 1457–1494, 2013."},"issue":"9","extern":1,"intvolume":"       149","status":"public"},{"publist_id":"4436","title":"Highly adaptive liquid simulations on tetrahedral meshes","article_number":"103","day":"01","file":[{"checksum":"aeea6b0ff2b27c695aeb8408c7d2fc50","file_id":"5279","date_updated":"2020-07-14T12:45:41Z","access_level":"open_access","date_created":"2018-12-12T10:17:25Z","file_name":"IST-2016-605-v1+1_tetflip_fixed.pdf","creator":"system","file_size":8601561,"content_type":"application/pdf","relation":"main_file"}],"author":[{"last_name":"Ando","first_name":"Ryoichi","full_name":"Ando, Ryoichi"},{"first_name":"Nils","last_name":"Thuerey","full_name":"Thuerey, Nils"},{"full_name":"Wojtan, Christopher J","orcid":"0000-0001-6646-5546","id":"3C61F1D2-F248-11E8-B48F-1D18A9856A87","first_name":"Christopher J","last_name":"Wojtan"}],"article_processing_charge":"No","scopus_import":"1","publication":"ACM Transactions on Graphics","department":[{"_id":"ChWo"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"ACM","quality_controlled":"1","doi":"10.1145/2461912.2461982","pubrep_id":"605","language":[{"iso":"eng"}],"issue":"4","file_date_updated":"2020-07-14T12:45:41Z","date_created":"2018-12-11T11:57:50Z","volume":32,"date_updated":"2024-11-19T11:56:45Z","abstract":[{"lang":"eng","text":"We introduce a new method for efficiently simulating liquid with extreme amounts of spatial adaptivity. Our method combines several key components to drastically speed up the simulation of large-scale fluid phenomena: We leverage an alternative Eulerian tetrahedral mesh discretization to significantly reduce the complexity of the pressure solve while increasing the robustness with respect to element quality and removing the possibility of locking. Next, we enable subtle free-surface phenomena by deriving novel second-order boundary conditions consistent with our discretization. We couple this discretization with a spatially adaptive Fluid-Implicit Particle (FLIP) method, enabling efficient, robust, minimally-dissipative simulations that can undergo sharp changes in spatial resolution while minimizing artifacts. Along the way, we provide a new method for generating a smooth and detailed surface from a set of particles with variable sizes. Finally, we explore several new sizing functions for determining spatially adaptive simulation resolutions, and we show how to couple them to our simulator. We combine each of these elements to produce a simulation algorithm that is capable of creating animations at high maximum resolutions while avoiding common pitfalls like inaccurate boundary conditions and inefficient computation."}],"type":"journal_article","oa_version":"Submitted Version","month":"07","_id":"2466","year":"2013","date_published":"2013-07-01T00:00:00Z","ddc":["000"],"has_accepted_license":"1","oa":1,"publication_status":"published","intvolume":"        32","status":"public"},{"has_accepted_license":"1","oa":1,"publication_status":"published","ddc":["000"],"date_published":"2013-07-01T00:00:00Z","status":"public","citation":{"ama":"Bernstein G, Wojtan C. Putting holes in holey geometry: Topology change for arbitrary surfaces. <i>ACM Transactions on Graphics</i>. 2013;32(4). doi:<a href=\"https://doi.org/10.1145/2461912.2462027\">10.1145/2461912.2462027</a>","ista":"Bernstein G, Wojtan C. 2013. Putting holes in holey geometry: Topology change for arbitrary surfaces. ACM Transactions on Graphics. 32(4), 34.","mla":"Bernstein, Gilbert, and Chris Wojtan. “Putting Holes in Holey Geometry: Topology Change for Arbitrary Surfaces.” <i>ACM Transactions on Graphics</i>, vol. 32, no. 4, 34, ACM, 2013, doi:<a href=\"https://doi.org/10.1145/2461912.2462027\">10.1145/2461912.2462027</a>.","apa":"Bernstein, G., &#38; Wojtan, C. (2013). Putting holes in holey geometry: Topology change for arbitrary surfaces. <i>ACM Transactions on Graphics</i>. ACM. <a href=\"https://doi.org/10.1145/2461912.2462027\">https://doi.org/10.1145/2461912.2462027</a>","ieee":"G. Bernstein and C. Wojtan, “Putting holes in holey geometry: Topology change for arbitrary surfaces,” <i>ACM Transactions on Graphics</i>, vol. 32, no. 4. ACM, 2013.","chicago":"Bernstein, Gilbert, and Chris Wojtan. “Putting Holes in Holey Geometry: Topology Change for Arbitrary Surfaces.” <i>ACM Transactions on Graphics</i>. ACM, 2013. <a href=\"https://doi.org/10.1145/2461912.2462027\">https://doi.org/10.1145/2461912.2462027</a>.","short":"G. Bernstein, C. Wojtan, ACM Transactions on Graphics 32 (2013)."},"intvolume":"        32","oa_version":"Submitted Version","type":"journal_article","month":"07","abstract":[{"lang":"eng","text":"This paper presents a method for computing topology changes for triangle meshes in an interactive geometric modeling environment. Most triangle meshes in practice do not exhibit desirable geometric properties, so we develop a solution that is independent of standard assumptions and robust to geometric errors. Specifically, we provide the first method for topology change applicable to arbitrary non-solid, non-manifold, non-closed, self-intersecting surfaces. We prove that this new method for topology change produces the expected conventional results when applied to solid (closed, manifold, non-self-intersecting) surfaces---that is, we prove a backwards-compatibility property relative to prior work. Beyond solid surfaces, we present empirical evidence that our method remains tolerant to a variety of surface aberrations through the incorporation of a novel error correction scheme. Finally, we demonstrate how topology change applied to non-solid objects enables wholly new and useful behaviors."}],"date_updated":"2023-02-23T10:44:16Z","date_created":"2018-12-11T11:57:50Z","file_date_updated":"2020-07-14T12:45:41Z","volume":32,"year":"2013","_id":"2467","pubrep_id":"604","quality_controlled":"1","doi":"10.1145/2461912.2462027","issue":"4","language":[{"iso":"eng"}],"file":[{"file_id":"4768","date_updated":"2020-07-14T12:45:41Z","checksum":"9c8425d62246996ca632c5a01870515b","date_created":"2018-12-12T10:09:43Z","access_level":"open_access","file_name":"IST-2016-604-v1+1_toptop2013.pdf","file_size":3514674,"content_type":"application/pdf","relation":"main_file","creator":"system"}],"day":"01","author":[{"full_name":"Bernstein, Gilbert","last_name":"Bernstein","first_name":"Gilbert"},{"first_name":"Christopher J","last_name":"Wojtan","id":"3C61F1D2-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6646-5546","full_name":"Wojtan, Christopher J"}],"publist_id":"4435","article_number":"34","title":"Putting holes in holey geometry: Topology change for arbitrary surfaces","department":[{"_id":"ChWo"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"ACM","scopus_import":1,"publication":"ACM Transactions on Graphics"},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"ACM","department":[{"_id":"ChWo"}],"publication":"ACM Transactions on Graphics","scopus_import":1,"author":[{"first_name":"Morten","last_name":"Bojsen-Hansen","full_name":"Bojsen-Hansen, Morten","id":"439F0C8C-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4417-3224"},{"first_name":"Christopher J","last_name":"Wojtan","full_name":"Wojtan, Christopher J","orcid":"0000-0001-6646-5546","id":"3C61F1D2-F248-11E8-B48F-1D18A9856A87"}],"day":"01","file":[{"checksum":"53d905e0180e23ef3e813b969ffed4e1","file_id":"4761","date_updated":"2020-07-14T12:45:41Z","access_level":"open_access","date_created":"2018-12-12T10:09:37Z","file_name":"IST-2016-603-v1+1_liquidError_web.pdf","creator":"system","file_size":5813685,"content_type":"application/pdf","relation":"main_file"}],"article_number":"68","title":"Liquid surface tracking with error compensation","publist_id":"4434","issue":"4","language":[{"iso":"eng"}],"pubrep_id":"603","doi":"10.1145/2461912.2461991","quality_controlled":"1","year":"2013","_id":"2468","oa_version":"Submitted Version","month":"07","type":"journal_article","abstract":[{"text":"Our work concerns the combination of an Eulerian liquid simulation with a high-resolution surface tracker (e.g. the level set method or a Lagrangian triangle mesh). The naive application of a high-resolution surface tracker to a low-resolution velocity field can produce many visually disturbing physical and topological artifacts that limit their use in practice. We address these problems by defining an error function which compares the current state of the surface tracker to the set of physically valid surface states. By reducing this error with a gradient descent technique, we introduce a novel physics-based surface fairing method. Similarly, by treating this error function as a potential energy, we derive a new surface correction force that mimics the vortex sheet equations. We demonstrate our results with both level set and mesh-based surface trackers.","lang":"eng"}],"date_updated":"2023-02-23T10:44:18Z","volume":32,"date_created":"2018-12-11T11:57:50Z","file_date_updated":"2020-07-14T12:45:41Z","status":"public","intvolume":"        32","citation":{"short":"M. Bojsen-Hansen, C. Wojtan, ACM Transactions on Graphics 32 (2013).","chicago":"Bojsen-Hansen, Morten, and Chris Wojtan. “Liquid Surface Tracking with Error Compensation.” <i>ACM Transactions on Graphics</i>. ACM, 2013. <a href=\"https://doi.org/10.1145/2461912.2461991\">https://doi.org/10.1145/2461912.2461991</a>.","ieee":"M. Bojsen-Hansen and C. Wojtan, “Liquid surface tracking with error compensation,” <i>ACM Transactions on Graphics</i>, vol. 32, no. 4. ACM, 2013.","apa":"Bojsen-Hansen, M., &#38; Wojtan, C. (2013). Liquid surface tracking with error compensation. <i>ACM Transactions on Graphics</i>. ACM. <a href=\"https://doi.org/10.1145/2461912.2461991\">https://doi.org/10.1145/2461912.2461991</a>","ista":"Bojsen-Hansen M, Wojtan C. 2013. Liquid surface tracking with error compensation. ACM Transactions on Graphics. 32(4), 68.","mla":"Bojsen-Hansen, Morten, and Chris Wojtan. “Liquid Surface Tracking with Error Compensation.” <i>ACM Transactions on Graphics</i>, vol. 32, no. 4, 68, ACM, 2013, doi:<a href=\"https://doi.org/10.1145/2461912.2461991\">10.1145/2461912.2461991</a>.","ama":"Bojsen-Hansen M, Wojtan C. Liquid surface tracking with error compensation. <i>ACM Transactions on Graphics</i>. 2013;32(4). doi:<a href=\"https://doi.org/10.1145/2461912.2461991\">10.1145/2461912.2461991</a>"},"oa":1,"publication_status":"published","has_accepted_license":"1","date_published":"2013-07-01T00:00:00Z","ddc":["000"]},{"language":[{"iso":"eng"}],"issue":"14","quality_controlled":"1","doi":"10.1016/j.cub.2013.06.019","scopus_import":1,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"publication":"Current Biology","pmid":1,"department":[{"_id":"CaHe"}],"publisher":"Cell Press","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publist_id":"4433","title":"Three functions of cadherins in cell adhesion","day":"22","file":[{"file_name":"2013_CurrentBiology_Maitre.pdf","creator":"dernst","file_size":247320,"content_type":"application/pdf","relation":"main_file","checksum":"6a424b2f007b41d4955a9135793b2162","file_id":"5881","date_updated":"2020-07-14T12:45:41Z","access_level":"open_access","date_created":"2019-01-24T15:40:22Z"}],"author":[{"first_name":"Jean-Léon","last_name":"Maître","orcid":"0000-0002-3688-1474","id":"48F1E0D8-F248-11E8-B48F-1D18A9856A87","full_name":"Maître, Jean-Léon"},{"full_name":"Heisenberg, Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0912-4566","first_name":"Carl-Philipp J","last_name":"Heisenberg"}],"citation":{"chicago":"Maître, Jean-Léon, and Carl-Philipp J Heisenberg. “Three Functions of Cadherins in Cell Adhesion.” <i>Current Biology</i>. Cell Press, 2013. <a href=\"https://doi.org/10.1016/j.cub.2013.06.019\">https://doi.org/10.1016/j.cub.2013.06.019</a>.","ieee":"J.-L. Maître and C.-P. J. Heisenberg, “Three functions of cadherins in cell adhesion,” <i>Current Biology</i>, vol. 23, no. 14. Cell Press, pp. R626–R633, 2013.","short":"J.-L. Maître, C.-P.J. Heisenberg, Current Biology 23 (2013) R626–R633.","ama":"Maître J-L, Heisenberg C-PJ. Three functions of cadherins in cell adhesion. <i>Current Biology</i>. 2013;23(14):R626-R633. doi:<a href=\"https://doi.org/10.1016/j.cub.2013.06.019\">10.1016/j.cub.2013.06.019</a>","apa":"Maître, J.-L., &#38; Heisenberg, C.-P. J. (2013). Three functions of cadherins in cell adhesion. <i>Current Biology</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.cub.2013.06.019\">https://doi.org/10.1016/j.cub.2013.06.019</a>","ista":"Maître J-L, Heisenberg C-PJ. 2013. Three functions of cadherins in cell adhesion. Current Biology. 23(14), R626–R633.","mla":"Maître, Jean-Léon, and Carl-Philipp J. Heisenberg. “Three Functions of Cadherins in Cell Adhesion.” <i>Current Biology</i>, vol. 23, no. 14, Cell Press, 2013, pp. R626–33, doi:<a href=\"https://doi.org/10.1016/j.cub.2013.06.019\">10.1016/j.cub.2013.06.019</a>."},"intvolume":"        23","status":"public","external_id":{"pmid":["23885883"]},"ddc":["570"],"date_published":"2013-07-22T00:00:00Z","has_accepted_license":"1","publication_status":"published","oa":1,"_id":"2469","year":"2013","date_created":"2018-12-11T11:57:51Z","file_date_updated":"2020-07-14T12:45:41Z","volume":23,"date_updated":"2021-01-12T06:57:40Z","abstract":[{"text":"Cadherins are transmembrane proteins that mediate cell–cell adhesion in animals. By regulating contact formation and stability, cadherins play a crucial role in tissue morphogenesis and homeostasis. Here, we review the three major  unctions of cadherins in cell–cell contact formation and stability. Two of those functions lead to a decrease in interfacial ension at the forming cell–cell contact, thereby promoting contact expansion — first, by providing adhesion tension that lowers interfacial tension at the cell–cell contact, and second, by signaling to the actomyosin cytoskeleton in order to reduce cortex tension and thus interfacial tension at the contact. The third function of cadherins in cell–cell contact formation is to stabilize the contact by resisting mechanical forces that pull on the contact.","lang":"eng"}],"oa_version":"Published Version","type":"journal_article","month":"07","page":"R626 - R633"},{"extern":1,"intvolume":"        56","issue":"3","citation":{"ieee":"T. D. Browning, “The Lang-Weil estimate for cubic hypersurfaces,” <i>Canadian Mathematical Bulletin</i>, vol. 56, no. 3. Unknown, pp. 500–502, 2013.","chicago":"Browning, Timothy D. “The Lang-Weil Estimate for Cubic Hypersurfaces.” <i>Canadian Mathematical Bulletin</i>. Unknown, 2013. <a href=\"https://doi.org/10.4153/CMB-2011-177-4\">https://doi.org/10.4153/CMB-2011-177-4</a>.","short":"T.D. Browning, Canadian Mathematical Bulletin 56 (2013) 500–502.","ama":"Browning TD. The Lang-Weil estimate for cubic hypersurfaces. <i>Canadian Mathematical Bulletin</i>. 2013;56(3):500-502. doi:<a href=\"https://doi.org/10.4153/CMB-2011-177-4\">10.4153/CMB-2011-177-4</a>","mla":"Browning, Timothy D. “The Lang-Weil Estimate for Cubic Hypersurfaces.” <i>Canadian Mathematical Bulletin</i>, vol. 56, no. 3, Unknown, 2013, pp. 500–02, doi:<a href=\"https://doi.org/10.4153/CMB-2011-177-4\">10.4153/CMB-2011-177-4</a>.","ista":"Browning TD. 2013. The Lang-Weil estimate for cubic hypersurfaces. Canadian Mathematical Bulletin. 56(3), 500–502.","apa":"Browning, T. D. (2013). The Lang-Weil estimate for cubic hypersurfaces. <i>Canadian Mathematical Bulletin</i>. Unknown. <a href=\"https://doi.org/10.4153/CMB-2011-177-4\">https://doi.org/10.4153/CMB-2011-177-4</a>"},"status":"public","date_published":"2013-08-31T00:00:00Z","doi":"10.4153/CMB-2011-177-4","quality_controlled":0,"publication_status":"published","_id":"247","publication":"Canadian Mathematical Bulletin","acknowledgement":"EP/E053262/1\tEngineering and Physical Sciences Research Council","publisher":"Unknown","year":"2013","title":"The Lang-Weil estimate for cubic hypersurfaces","volume":56,"publist_id":"7657","date_created":"2018-12-11T11:45:25Z","author":[{"full_name":"Timothy Browning","id":"35827D50-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8314-0177","last_name":"Browning","first_name":"Timothy D"}],"page":"500 - 502","type":"journal_article","month":"08","abstract":[{"lang":"eng","text":"An improved estimate is provided for the number of Fq-rational points on a geometrically irreducible, projective, cubic hypersurface that is not equal to a cone."}],"date_updated":"2021-01-12T06:57:40Z","day":"31"},{"month":"07","type":"journal_article","oa_version":"Published Version","abstract":[{"lang":"eng","text":"Background:Auxin binding protein 1 (ABP1) is a putative auxin receptor and its function is indispensable for plant growth and development. ABP1 has been shown to be involved in auxin-dependent regulation of cell division and expansion, in plasma-membrane-related processes such as changes in transmembrane potential, and in the regulation of clathrin-dependent endocytosis. However, the ABP1-regulated downstream pathway remains elusive.Methodology/Principal Findings:Using auxin transport assays and quantitative analysis of cellular morphology we show that ABP1 regulates auxin efflux from tobacco BY-2 cells. The overexpression of ABP1can counterbalance increased auxin efflux and auxin starvation phenotypes caused by the overexpression of PIN auxin efflux carrier. Relevant mechanism involves the ABP1-controlled vesicle trafficking processes, including positive regulation of endocytosis of PIN auxin efflux carriers, as indicated by fluorescence recovery after photobleaching (FRAP) and pharmacological manipulations.Conclusions/Significance:The findings indicate the involvement of ABP1 in control of rate of auxin transport across plasma membrane emphasizing the role of ABP1 in regulation of PIN activity at the plasma membrane, and highlighting the relevance of ABP1 for the formation of developmentally important, PIN-dependent auxin gradients."}],"date_updated":"2021-01-12T06:57:40Z","volume":8,"file_date_updated":"2020-07-14T12:45:41Z","date_created":"2018-12-11T11:57:51Z","year":"2013","_id":"2470","publication_status":"published","oa":1,"has_accepted_license":"1","ddc":["570"],"date_published":"2013-07-23T00:00:00Z","status":"public","intvolume":"         8","citation":{"apa":"Čovanová, M., Sauer, M., Rychtář, J., Friml, J., Petrášek, J., &#38; Zažímalová, E. (2013). Overexpression of the auxin binding PROTEIN1 modulates PIN-dependent auxin transport in tobacco cells. <i>PLoS One</i>. Public Library of Science. <a href=\"https://doi.org/10.1371/journal.pone.0070050\">https://doi.org/10.1371/journal.pone.0070050</a>","mla":"Čovanová, Milada, et al. “Overexpression of the Auxin Binding PROTEIN1 Modulates PIN-Dependent Auxin Transport in Tobacco Cells.” <i>PLoS One</i>, vol. 8, no. 7, e70050, Public Library of Science, 2013, doi:<a href=\"https://doi.org/10.1371/journal.pone.0070050\">10.1371/journal.pone.0070050</a>.","ista":"Čovanová M, Sauer M, Rychtář J, Friml J, Petrášek J, Zažímalová E. 2013. Overexpression of the auxin binding PROTEIN1 modulates PIN-dependent auxin transport in tobacco cells. PLoS One. 8(7), e70050.","ama":"Čovanová M, Sauer M, Rychtář J, Friml J, Petrášek J, Zažímalová E. Overexpression of the auxin binding PROTEIN1 modulates PIN-dependent auxin transport in tobacco cells. <i>PLoS One</i>. 2013;8(7). doi:<a href=\"https://doi.org/10.1371/journal.pone.0070050\">10.1371/journal.pone.0070050</a>","short":"M. Čovanová, M. Sauer, J. Rychtář, J. Friml, J. Petrášek, E. Zažímalová, PLoS One 8 (2013).","chicago":"Čovanová, Milada, Michael Sauer, Jan Rychtář, Jiří Friml, Jan Petrášek, and Eva Zažímalová. “Overexpression of the Auxin Binding PROTEIN1 Modulates PIN-Dependent Auxin Transport in Tobacco Cells.” <i>PLoS One</i>. Public Library of Science, 2013. <a href=\"https://doi.org/10.1371/journal.pone.0070050\">https://doi.org/10.1371/journal.pone.0070050</a>.","ieee":"M. Čovanová, M. Sauer, J. Rychtář, J. Friml, J. Petrášek, and E. Zažímalová, “Overexpression of the auxin binding PROTEIN1 modulates PIN-dependent auxin transport in tobacco cells,” <i>PLoS One</i>, vol. 8, no. 7. Public Library of Science, 2013."},"author":[{"last_name":"Čovanová","first_name":"Milada","full_name":"Čovanová, Milada"},{"first_name":"Michael","last_name":"Sauer","full_name":"Sauer, Michael"},{"last_name":"Rychtář","first_name":"Jan","full_name":"Rychtář, Jan"},{"full_name":"Friml, Jirí","orcid":"0000-0002-8302-7596","id":"4159519E-F248-11E8-B48F-1D18A9856A87","first_name":"Jirí","last_name":"Friml"},{"last_name":"Petrášek","first_name":"Jan","full_name":"Petrášek, Jan"},{"full_name":"Zažímalová, Eva","first_name":"Eva","last_name":"Zažímalová"}],"file":[{"date_created":"2018-12-12T10:08:21Z","access_level":"open_access","file_id":"4681","date_updated":"2020-07-14T12:45:41Z","checksum":"2d47ef47616ef4de1d517d146548184e","file_size":2294955,"relation":"main_file","content_type":"application/pdf","creator":"system","file_name":"IST-2016-413-v1+1_journal.pone.0070050.pdf"}],"day":"23","article_number":"e70050","title":"Overexpression of the auxin binding PROTEIN1 modulates PIN-dependent auxin transport in tobacco cells","publist_id":"4432","publisher":"Public Library of Science","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"JiFr"}],"publication":"PLoS One","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"scopus_import":1,"pubrep_id":"413","doi":"10.1371/journal.pone.0070050","quality_controlled":"1","issue":"7","language":[{"iso":"eng"}]},{"date_created":"2018-12-11T11:57:51Z","file_date_updated":"2020-07-14T12:45:41Z","volume":8,"type":"journal_article","month":"07","oa_version":"Published Version","date_updated":"2021-01-12T06:57:41Z","abstract":[{"lang":"eng","text":"The impact of disulfide bonds on protein stability goes beyond simple equilibrium thermodynamics effects associated with the conformational entropy of the unfolded state. Indeed, disulfide crosslinks may play a role in the prevention of dysfunctional association and strongly affect the rates of irreversible enzyme inactivation, highly relevant in biotechnological applications. While these kinetic-stability effects remain poorly understood, by analogy with proposed mechanisms for processes of protein aggregation and fibrillogenesis, we propose that they may be determined by the properties of sparsely-populated, partially-unfolded intermediates. Here we report the successful design, on the basis of high temperature molecular-dynamics simulations, of six thermodynamically and kinetically stabilized variants of phytase from Citrobacter braakii (a biotechnologically important enzyme) with one, two or three engineered disulfides. Activity measurements and 3D crystal structure determination demonstrate that the engineered crosslinks do not cause dramatic alterations in the native structure. The inactivation kinetics for all the variants displays a strongly non-Arrhenius temperature dependence, with the time-scale for the irreversible denaturation process reaching a minimum at a given temperature within the range of the denaturation transition. We show this striking feature to be a signature of a key role played by a partially unfolded, intermediate state/ensemble. Energetic and mutational analyses confirm that the intermediate is highly unfolded (akin to a proposed critical intermediate in the misfolding of the prion protein), a result that explains the observed kinetic stabilization. Our results provide a rationale for the kinetic-stability consequences of disulfide-crosslink engineering and an experimental methodology to arrive at energetic/structural descriptions of the sparsely populated and elusive intermediates that play key roles in irreversible protein denaturation."}],"_id":"2471","year":"2013","ddc":["570"],"date_published":"2013-07-30T00:00:00Z","has_accepted_license":"1","publication_status":"published","oa":1,"citation":{"ieee":"I. Sanchez-Romero <i>et al.</i>, “Mechanism of protein kinetic stabilization by engineered disulfide crosslinks,” <i>PLoS One</i>, vol. 8, no. 7. Public Library of Science, 2013.","chicago":"Sanchez-Romero, Inmaculada, Antonio Ariza, Keith Wilson, Michael Skjøt, Jesper Vind, Leonardo De Maria, Lars Skov, and Jose Sánchez Ruiz. “Mechanism of Protein Kinetic Stabilization by Engineered Disulfide Crosslinks.” <i>PLoS One</i>. Public Library of Science, 2013. <a href=\"https://doi.org/10.1371/journal.pone.0070013\">https://doi.org/10.1371/journal.pone.0070013</a>.","short":"I. Sanchez-Romero, A. Ariza, K. Wilson, M. Skjøt, J. Vind, L. De Maria, L. Skov, J. Sánchez Ruiz, PLoS One 8 (2013).","ama":"Sanchez-Romero I, Ariza A, Wilson K, et al. Mechanism of protein kinetic stabilization by engineered disulfide crosslinks. <i>PLoS One</i>. 2013;8(7). doi:<a href=\"https://doi.org/10.1371/journal.pone.0070013\">10.1371/journal.pone.0070013</a>","mla":"Sanchez-Romero, Inmaculada, et al. “Mechanism of Protein Kinetic Stabilization by Engineered Disulfide Crosslinks.” <i>PLoS One</i>, vol. 8, no. 7, e70013, Public Library of Science, 2013, doi:<a href=\"https://doi.org/10.1371/journal.pone.0070013\">10.1371/journal.pone.0070013</a>.","ista":"Sanchez-Romero I, Ariza A, Wilson K, Skjøt M, Vind J, De Maria L, Skov L, Sánchez Ruiz J. 2013. Mechanism of protein kinetic stabilization by engineered disulfide crosslinks. PLoS One. 8(7), e70013.","apa":"Sanchez-Romero, I., Ariza, A., Wilson, K., Skjøt, M., Vind, J., De Maria, L., … Sánchez Ruiz, J. (2013). Mechanism of protein kinetic stabilization by engineered disulfide crosslinks. <i>PLoS One</i>. Public Library of Science. <a href=\"https://doi.org/10.1371/journal.pone.0070013\">https://doi.org/10.1371/journal.pone.0070013</a>"},"intvolume":"         8","status":"public","publist_id":"4430","article_number":"e70013","title":"Mechanism of protein kinetic stabilization by engineered disulfide crosslinks","day":"30","file":[{"file_name":"IST-2016-414-v1+1_journal.pone.0070013.pdf","relation":"main_file","content_type":"application/pdf","file_size":1323666,"creator":"system","date_updated":"2020-07-14T12:45:41Z","file_id":"5124","checksum":"c0c96cc76ed7ef0d036a31a7e33c9a37","date_created":"2018-12-12T10:15:07Z","access_level":"open_access"}],"author":[{"id":"3D9C5D30-F248-11E8-B48F-1D18A9856A87","full_name":"Sanchez Romero, Inmaculada","last_name":"Sanchez Romero","first_name":"Inmaculada"},{"full_name":"Ariza, Antonio","first_name":"Antonio","last_name":"Ariza"},{"full_name":"Wilson, Keith","first_name":"Keith","last_name":"Wilson"},{"full_name":"Skjøt, Michael","first_name":"Michael","last_name":"Skjøt"},{"last_name":"Vind","first_name":"Jesper","full_name":"Vind, Jesper"},{"last_name":"De Maria","first_name":"Leonardo","full_name":"De Maria, Leonardo"},{"full_name":"Skov, Lars","last_name":"Skov","first_name":"Lars"},{"full_name":"Sánchez Ruiz, Jose","first_name":"Jose","last_name":"Sánchez Ruiz"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"scopus_import":1,"publication":"PLoS One","department":[{"_id":"HaJa"}],"publisher":"Public Library of Science","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","quality_controlled":"1","doi":"10.1371/journal.pone.0070013","pubrep_id":"414","issue":"7","language":[{"iso":"eng"}]},{"file_date_updated":"2020-07-14T12:45:41Z","date_created":"2018-12-11T11:57:52Z","volume":8,"date_updated":"2021-01-12T06:57:41Z","abstract":[{"text":"Plant-specific PIN-formed (PIN) efflux transporters for the plant hormone auxin are required for tissue-specific directional auxin transport and cellular auxin homeostasis. The Arabidopsis PIN protein family has been shown to play important roles in developmental processes such as embryogenesis, organogenesis, vascular tissue differentiation, root meristem patterning and tropic growth. Here we analyzed roles of the less characterised Arabidopsis PIN6 auxin transporter. PIN6 is auxin-inducible and is expressed during multiple auxin-regulated developmental processes. Loss of pin6 function interfered with primary root growth and lateral root development. Misexpression of PIN6 affected auxin transport and interfered with auxin homeostasis in other growth processes such as shoot apical dominance, lateral root primordia development, adventitious root formation, root hair outgrowth and root waving. These changes in auxin-regulated growth correlated with a reduction in total auxin transport as well as with an altered activity of DR5-GUS auxin response reporter. Overall, the data indicate that PIN6 regulates auxin homeostasis during plant development.","lang":"eng"}],"month":"07","type":"journal_article","oa_version":"Published Version","_id":"2472","year":"2013","date_published":"2013-07-29T00:00:00Z","ddc":["580","570"],"has_accepted_license":"1","oa":1,"publication_status":"published","citation":{"short":"C. Cazzonelli, M. Vanstraelen, S. Simon, K. Yin, A. Carron Arthur, N. Nisar, G. Tarle, A. Cuttriss, I. Searle, E. Benková, U. Mathesius, J. Masle, J. Friml, B. Pogson, PLoS One 8 (2013).","chicago":"Cazzonelli, Christopher, Marleen Vanstraelen, Sibu Simon, Kuide Yin, Ashley Carron Arthur, Nazia Nisar, Gauri Tarle, et al. “Role of the Arabidopsis PIN6 Auxin Transporter in Auxin Homeostasis and Auxin-Mediated Development.” <i>PLoS One</i>. Public Library of Science, 2013. <a href=\"https://doi.org/10.1371/journal.pone.0070069\">https://doi.org/10.1371/journal.pone.0070069</a>.","ieee":"C. Cazzonelli <i>et al.</i>, “Role of the Arabidopsis PIN6 auxin transporter in auxin homeostasis and auxin-mediated development,” <i>PLoS One</i>, vol. 8, no. 7. Public Library of Science, 2013.","apa":"Cazzonelli, C., Vanstraelen, M., Simon, S., Yin, K., Carron Arthur, A., Nisar, N., … Pogson, B. (2013). Role of the Arabidopsis PIN6 auxin transporter in auxin homeostasis and auxin-mediated development. <i>PLoS One</i>. Public Library of Science. <a href=\"https://doi.org/10.1371/journal.pone.0070069\">https://doi.org/10.1371/journal.pone.0070069</a>","ista":"Cazzonelli C, Vanstraelen M, Simon S, Yin K, Carron Arthur A, Nisar N, Tarle G, Cuttriss A, Searle I, Benková E, Mathesius U, Masle J, Friml J, Pogson B. 2013. Role of the Arabidopsis PIN6 auxin transporter in auxin homeostasis and auxin-mediated development. PLoS One. 8(7), e70069.","mla":"Cazzonelli, Christopher, et al. “Role of the Arabidopsis PIN6 Auxin Transporter in Auxin Homeostasis and Auxin-Mediated Development.” <i>PLoS One</i>, vol. 8, no. 7, e70069, Public Library of Science, 2013, doi:<a href=\"https://doi.org/10.1371/journal.pone.0070069\">10.1371/journal.pone.0070069</a>.","ama":"Cazzonelli C, Vanstraelen M, Simon S, et al. Role of the Arabidopsis PIN6 auxin transporter in auxin homeostasis and auxin-mediated development. <i>PLoS One</i>. 2013;8(7). doi:<a href=\"https://doi.org/10.1371/journal.pone.0070069\">10.1371/journal.pone.0070069</a>"},"intvolume":"         8","status":"public","publist_id":"4431","title":"Role of the Arabidopsis PIN6 auxin transporter in auxin homeostasis and auxin-mediated development","article_number":"e70069","file":[{"date_updated":"2020-07-14T12:45:41Z","file_id":"5222","checksum":"3be71828b6c2ba9c90eb7056e3f7f57a","date_created":"2018-12-12T10:16:34Z","access_level":"open_access","file_name":"IST-2015-393-v1+1_journal.pone.0070069.pdf","relation":"main_file","content_type":"application/pdf","file_size":9003465,"creator":"system"}],"day":"29","author":[{"full_name":"Cazzonelli, Christopher","last_name":"Cazzonelli","first_name":"Christopher"},{"first_name":"Marleen","last_name":"Vanstraelen","full_name":"Vanstraelen, Marleen"},{"full_name":"Simon, Sibu","orcid":"0000-0002-1998-6741","id":"4542EF9A-F248-11E8-B48F-1D18A9856A87","first_name":"Sibu","last_name":"Simon"},{"last_name":"Yin","first_name":"Kuide","full_name":"Yin, Kuide"},{"full_name":"Carron Arthur, Ashley","last_name":"Carron Arthur","first_name":"Ashley"},{"first_name":"Nazia","last_name":"Nisar","full_name":"Nisar, Nazia"},{"full_name":"Tarle, Gauri","first_name":"Gauri","last_name":"Tarle"},{"full_name":"Cuttriss, Abby","last_name":"Cuttriss","first_name":"Abby"},{"full_name":"Searle, Iain","first_name":"Iain","last_name":"Searle"},{"first_name":"Eva","last_name":"Benková","orcid":"0000-0002-8510-9739","id":"38F4F166-F248-11E8-B48F-1D18A9856A87","full_name":"Benková, Eva"},{"full_name":"Mathesius, Ulrike","first_name":"Ulrike","last_name":"Mathesius"},{"full_name":"Masle, Josette","last_name":"Masle","first_name":"Josette"},{"last_name":"Friml","first_name":"Jirí","full_name":"Friml, Jirí","id":"4159519E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8302-7596"},{"full_name":"Pogson, Barry","last_name":"Pogson","first_name":"Barry"}],"ec_funded":1,"scopus_import":1,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"publication":"PLoS One","department":[{"_id":"JiFr"},{"_id":"EvBe"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"Public Library of Science","quality_controlled":"1","doi":"10.1371/journal.pone.0070069","pubrep_id":"393","language":[{"iso":"eng"}],"issue":"7","project":[{"name":"Hormonal cross-talk in plant organogenesis","call_identifier":"FP7","_id":"253FCA6A-B435-11E9-9278-68D0E5697425","grant_number":"207362"},{"grant_number":"282300","name":"Polarity and subcellular dynamics in plants","_id":"25716A02-B435-11E9-9278-68D0E5697425","call_identifier":"FP7"}]},{"year":"2013","_id":"2473","page":"75 - 89","date_updated":"2021-01-12T06:57:42Z","abstract":[{"text":"When a mutation with selective advantage s spreads through a panmictic population, it may cause two lineages at a linked locus to coalesce; the probability of coalescence is exp(−2rT), where T∼log(2Ns)/s is the time to fixation, N is the number of haploid individuals, and r is the recombination rate. Population structure delays fixation, and so weakens the effect of a selective sweep. However, favourable alleles spread through a spatially continuous population behind a narrow wavefront; ancestral lineages are confined at the tip of this front, and so coalesce rapidly. In extremely dense populations, coalescence is dominated by rare fluctuations ahead of the front. However, we show that for moderate densities, a simple quasi-deterministic approximation applies: the rate of coalescence within the front is λ∼2g(η)/(ρℓ), where ρ is the population density and  is the characteristic scale of the wavefront; g(η) depends only on the strength of random drift,  . The net effect of a sweep on coalescence also depends crucially on whether two lineages are ever both within the wavefront at the same time: even in the extreme case when coalescence within the front is instantaneous, the net rate of coalescence may be lower than in a single panmictic population. Sweeps can also have a substantial impact on the rate of gene flow. A single lineage will jump to a new location when it is hit by a sweep, with mean square displacement  ; this can be substantial if the species’ range, L, is large, even if the species-wide rate of sweeps per map length, Λ/R, is small. This effect is half as strong in two dimensions. In contrast, the rate of coalescence between lineages, at random locations in space and on the genetic map, is proportional to (c/L)(Λ/R), where c is the wavespeed: thus, on average, one-dimensional structure is likely to reduce coalescence due to sweeps, relative to panmixis. In two dimensions, genes must move along the front before they can coalesce; this process is rapid, being dominated by rare fluctuations. This leads to a dramatically higher rate of coalescence within the wavefront than if lineages simply diffused along the front. Nevertheless, the net rate of coalescence due to a sweep through a two-dimensional population is likely to be lower than it would be with panmixis.","lang":"eng"}],"oa_version":"Submitted Version","month":"01","type":"journal_article","volume":87,"date_created":"2018-12-11T11:57:52Z","file_date_updated":"2020-07-14T12:45:41Z","status":"public","intvolume":"        87","citation":{"short":"N.H. Barton, A. Etheridge, J. Kelleher, A. Véber, Theoretical Population Biology 87 (2013) 75–89.","chicago":"Barton, Nicholas H, Alison Etheridge, Jerome Kelleher, and Amandine Véber. “Genetic Hitch-Hiking in Spatially Extended Populations.” <i>Theoretical Population Biology</i>. Elsevier, 2013. <a href=\"https://doi.org/10.1016/j.tpb.2012.12.001\">https://doi.org/10.1016/j.tpb.2012.12.001</a>.","ieee":"N. H. Barton, A. Etheridge, J. Kelleher, and A. Véber, “Genetic hitch-hiking in spatially extended populations,” <i>Theoretical Population Biology</i>, vol. 87, no. 8. Elsevier, pp. 75–89, 2013.","apa":"Barton, N. H., Etheridge, A., Kelleher, J., &#38; Véber, A. (2013). Genetic hitch-hiking in spatially extended populations. <i>Theoretical Population Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.tpb.2012.12.001\">https://doi.org/10.1016/j.tpb.2012.12.001</a>","ista":"Barton NH, Etheridge A, Kelleher J, Véber A. 2013. Genetic hitch-hiking in spatially extended populations. Theoretical Population Biology. 87(8), 75–89.","mla":"Barton, Nicholas H., et al. “Genetic Hitch-Hiking in Spatially Extended Populations.” <i>Theoretical Population Biology</i>, vol. 87, no. 8, Elsevier, 2013, pp. 75–89, doi:<a href=\"https://doi.org/10.1016/j.tpb.2012.12.001\">10.1016/j.tpb.2012.12.001</a>.","ama":"Barton NH, Etheridge A, Kelleher J, Véber A. Genetic hitch-hiking in spatially extended populations. <i>Theoretical Population Biology</i>. 2013;87(8):75-89. doi:<a href=\"https://doi.org/10.1016/j.tpb.2012.12.001\">10.1016/j.tpb.2012.12.001</a>"},"oa":1,"publication_status":"published","has_accepted_license":"1","ddc":["570"],"date_published":"2013-01-03T00:00:00Z","publisher":"Elsevier","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"NiBa"}],"publication":"Theoretical Population Biology","ec_funded":1,"scopus_import":1,"author":[{"orcid":"0000-0002-8548-5240","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","full_name":"Barton, Nicholas H","last_name":"Barton","first_name":"Nicholas H"},{"full_name":"Etheridge, Alison","last_name":"Etheridge","first_name":"Alison"},{"first_name":"Jerome","last_name":"Kelleher","full_name":"Kelleher, Jerome"},{"last_name":"Véber","first_name":"Amandine","full_name":"Véber, Amandine"}],"day":"03","file":[{"date_updated":"2020-07-14T12:45:41Z","file_id":"5376","checksum":"4274ec1f433b838a7d5b941cc9684ca7","date_created":"2018-12-12T10:18:54Z","access_level":"open_access","file_name":"IST-2013-118-v1+1_bartonetalRevision.pdf","content_type":"application/pdf","relation":"main_file","file_size":1706282,"creator":"system"}],"title":"Genetic hitch-hiking in spatially extended populations","publist_id":"4428","project":[{"grant_number":"250152","_id":"25B07788-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","name":"Limits to selection in biology and in evolutionary computation"}],"language":[{"iso":"eng"}],"issue":"8","pubrep_id":"118","doi":"10.1016/j.tpb.2012.12.001","quality_controlled":"1"},{"_id":"2478","publication":"PNAS","year":"2013","publisher":"National Academy of Sciences","publist_id":"4423","date_created":"2018-12-11T11:57:54Z","volume":110,"title":"Neuroligin-1 controls synaptic abundance of NMDA-type glutamate receptors through extracellular coupling","month":"01","type":"journal_article","date_updated":"2021-01-12T06:57:43Z","day":"08","abstract":[{"text":"Despite the pivotal functions of the NMDA receptor (NMDAR) for neural circuit development and synaptic plasticity, the molecular mechanisms underlying the dynamics of NMDAR trafficking are poorly understood. The cell adhesion molecule neuroligin-1 (NL1) modifies NMDAR-dependent synaptic transmission and synaptic plasticity, but it is unclear whether NL1 controls synaptic accumulation or function of the receptors. Here, we provide evidence that NL1 regulates the abundance of NMDARs at postsynaptic sites. This function relies on extracellular, NL1 isoform-specific sequences that facilitate biochemical interactions between NL1 and the NMDAR GluN1 subunit. Our work uncovers NL1 isoform-specific cisinteractions with ionotropic glutamate receptors as a key mechanism for controlling synaptic properties.","lang":"eng"}],"author":[{"full_name":"Budreck, Elaine C","last_name":"Budreck","first_name":"Elaine"},{"first_name":"Oh","last_name":"Kwon","full_name":"Kwon, Oh-Bin"},{"first_name":"Jung","last_name":"Jung","full_name":"Jung, Jung-Hoon"},{"full_name":"Baudouin, Stéphane J","last_name":"Baudouin","first_name":"Stéphane"},{"full_name":"Thommen, Albert","first_name":"Albert","last_name":"Thommen"},{"first_name":"Hye","last_name":"Kim","full_name":"Kim, Hye-Sun"},{"full_name":"Fukazawa, Yugo","first_name":"Yugo","last_name":"Fukazawa"},{"full_name":"Harumi Harada","orcid":"0000-0001-7429-7896","id":"2E55CDF2-F248-11E8-B48F-1D18A9856A87","first_name":"Harumi","last_name":"Harada"},{"full_name":"Tabuchi, Katsuhiko","first_name":"Katsuhiko","last_name":"Tabuchi"},{"full_name":"Ryuichi Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444","first_name":"Ryuichi","last_name":"Shigemoto"},{"full_name":"Scheiffele, Peter","first_name":"Peter","last_name":"Scheiffele"},{"full_name":"Kim, Joung-Hun","first_name":"Joung","last_name":"Kim"}],"page":"725 - 730","issue":"2","citation":{"ieee":"E. Budreck <i>et al.</i>, “Neuroligin-1 controls synaptic abundance of NMDA-type glutamate receptors through extracellular coupling,” <i>PNAS</i>, vol. 110, no. 2. National Academy of Sciences, pp. 725–730, 2013.","chicago":"Budreck, Elaine, Oh Kwon, Jung Jung, Stéphane Baudouin, Albert Thommen, Hye Kim, Yugo Fukazawa, et al. “Neuroligin-1 Controls Synaptic Abundance of NMDA-Type Glutamate Receptors through Extracellular Coupling.” <i>PNAS</i>. National Academy of Sciences, 2013. <a href=\"https://doi.org/10.1073/pnas.1214718110\">https://doi.org/10.1073/pnas.1214718110</a>.","short":"E. Budreck, O. Kwon, J. Jung, S. Baudouin, A. Thommen, H. Kim, Y. Fukazawa, H. Harada, K. Tabuchi, R. Shigemoto, P. Scheiffele, J. Kim, PNAS 110 (2013) 725–730.","ama":"Budreck E, Kwon O, Jung J, et al. Neuroligin-1 controls synaptic abundance of NMDA-type glutamate receptors through extracellular coupling. <i>PNAS</i>. 2013;110(2):725-730. doi:<a href=\"https://doi.org/10.1073/pnas.1214718110\">10.1073/pnas.1214718110</a>","mla":"Budreck, Elaine, et al. “Neuroligin-1 Controls Synaptic Abundance of NMDA-Type Glutamate Receptors through Extracellular Coupling.” <i>PNAS</i>, vol. 110, no. 2, National Academy of Sciences, 2013, pp. 725–30, doi:<a href=\"https://doi.org/10.1073/pnas.1214718110\">10.1073/pnas.1214718110</a>.","ista":"Budreck E, Kwon O, Jung J, Baudouin S, Thommen A, Kim H, Fukazawa Y, Harada H, Tabuchi K, Shigemoto R, Scheiffele P, Kim J. 2013. Neuroligin-1 controls synaptic abundance of NMDA-type glutamate receptors through extracellular coupling. PNAS. 110(2), 725–730.","apa":"Budreck, E., Kwon, O., Jung, J., Baudouin, S., Thommen, A., Kim, H., … Kim, J. (2013). Neuroligin-1 controls synaptic abundance of NMDA-type glutamate receptors through extracellular coupling. <i>PNAS</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.1214718110\">https://doi.org/10.1073/pnas.1214718110</a>"},"extern":1,"intvolume":"       110","status":"public","quality_controlled":0,"doi":"10.1073/pnas.1214718110","date_published":"2013-01-08T00:00:00Z","publication_status":"published"},{"title":"Density of Châtelet surfaces failing the Hasse principle","volume":108,"date_created":"2018-12-11T11:45:26Z","publist_id":"7652","page":"1030 - 1078","author":[{"full_name":"de la Bretèche, Régis","last_name":"De La Bretèche","first_name":"Régis"},{"last_name":"Browning","first_name":"Timothy D","full_name":"Timothy Browning","id":"35827D50-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8314-0177"}],"date_updated":"2021-01-12T06:57:51Z","day":"29","abstract":[{"lang":"eng","text":"Châtelet surfaces provide a rich source of geometrically rational surfaces that do not always satisfy the Hasse principle. Restricting attention to a special class of Châtelet surfaces, we investigate the frequency that such counter-examples arise over the rational numbers."}],"month":"11","type":"journal_article","publication":"Proceedings of the London Mathematical Society","_id":"250","publisher":"Oxford University Press","acknowledgement":"While working on this paper, the first author was supported by an IUF Junior and ANR while the second author was supported by ERC grant 306457.","year":"2013","date_published":"2013-11-29T00:00:00Z","doi":"10.1112/plms/pdt060","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1210.4010"}],"quality_controlled":0,"oa":1,"publication_status":"published","extern":1,"intvolume":"       108","citation":{"short":"R. De La Bretèche, T.D. Browning, Proceedings of the London Mathematical Society 108 (2013) 1030–1078.","chicago":"De La Bretèche, Régis, and Timothy D Browning. “Density of Châtelet Surfaces Failing the Hasse Principle.” <i>Proceedings of the London Mathematical Society</i>. Oxford University Press, 2013. <a href=\"https://doi.org/10.1112/plms/pdt060\">https://doi.org/10.1112/plms/pdt060</a>.","ieee":"R. De La Bretèche and T. D. Browning, “Density of Châtelet surfaces failing the Hasse principle,” <i>Proceedings of the London Mathematical Society</i>, vol. 108, no. 4. Oxford University Press, pp. 1030–1078, 2013.","apa":"De La Bretèche, R., &#38; Browning, T. D. (2013). Density of Châtelet surfaces failing the Hasse principle. <i>Proceedings of the London Mathematical Society</i>. Oxford University Press. <a href=\"https://doi.org/10.1112/plms/pdt060\">https://doi.org/10.1112/plms/pdt060</a>","ista":"De La Bretèche R, Browning TD. 2013. Density of Châtelet surfaces failing the Hasse principle. Proceedings of the London Mathematical Society. 108(4), 1030–1078.","mla":"De La Bretèche, Régis, and Timothy D. Browning. “Density of Châtelet Surfaces Failing the Hasse Principle.” <i>Proceedings of the London Mathematical Society</i>, vol. 108, no. 4, Oxford University Press, 2013, pp. 1030–78, doi:<a href=\"https://doi.org/10.1112/plms/pdt060\">10.1112/plms/pdt060</a>.","ama":"De La Bretèche R, Browning TD. Density of Châtelet surfaces failing the Hasse principle. <i>Proceedings of the London Mathematical Society</i>. 2013;108(4):1030-1078. doi:<a href=\"https://doi.org/10.1112/plms/pdt060\">10.1112/plms/pdt060</a>"},"issue":"4","status":"public"},{"year":"2013","publisher":"Universite de Bordeaux I","publication":"Journal de Theorie des Nombres de Bordeaux","_id":"251","date_updated":"2021-01-12T06:57:55Z","abstract":[{"text":"We study the density of varieties in a certain family which do not satisfy the Hasse principle. This work relies on results recently obtained by Colliot-Thélène [3].","lang":"eng"}],"day":"14","type":"journal_article","month":"05","author":[{"first_name":"Régis","last_name":"De La Bretèche","full_name":"de la Bretèche, Régis"},{"last_name":"Browning","first_name":"Timothy D","full_name":"Timothy Browning","id":"35827D50-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8314-0177"}],"page":"25 - 44","publist_id":"7651","date_created":"2018-12-11T11:45:26Z","volume":26,"title":"Counter examples to the Hasse principle among certain coflasque tori","status":"public","citation":{"ama":"De La Bretèche R, Browning TD. Counter examples to the Hasse principle among certain coflasque tori. <i>Journal de Theorie des Nombres de Bordeaux</i>. 2013;26(1):25-44. doi:<a href=\"https://doi.org/10.5802/jtnb.857\">10.5802/jtnb.857</a>","apa":"De La Bretèche, R., &#38; Browning, T. D. (2013). Counter examples to the Hasse principle among certain coflasque tori. <i>Journal de Theorie Des Nombres de Bordeaux</i>. Universite de Bordeaux I. <a href=\"https://doi.org/10.5802/jtnb.857\">https://doi.org/10.5802/jtnb.857</a>","ista":"De La Bretèche R, Browning TD. 2013. Counter examples to the Hasse principle among certain coflasque tori. Journal de Theorie des Nombres de Bordeaux. 26(1), 25–44.","mla":"De La Bretèche, Régis, and Timothy D. Browning. “Counter Examples to the Hasse Principle among Certain Coflasque Tori.” <i>Journal de Theorie Des Nombres de Bordeaux</i>, vol. 26, no. 1, Universite de Bordeaux I, 2013, pp. 25–44, doi:<a href=\"https://doi.org/10.5802/jtnb.857\">10.5802/jtnb.857</a>.","chicago":"De La Bretèche, Régis, and Timothy D Browning. “Counter Examples to the Hasse Principle among Certain Coflasque Tori.” <i>Journal de Theorie Des Nombres de Bordeaux</i>. Universite de Bordeaux I, 2013. <a href=\"https://doi.org/10.5802/jtnb.857\">https://doi.org/10.5802/jtnb.857</a>.","ieee":"R. De La Bretèche and T. D. Browning, “Counter examples to the Hasse principle among certain coflasque tori,” <i>Journal de Theorie des Nombres de Bordeaux</i>, vol. 26, no. 1. Universite de Bordeaux I, pp. 25–44, 2013.","short":"R. De La Bretèche, T.D. Browning, Journal de Theorie Des Nombres de Bordeaux 26 (2013) 25–44."},"issue":"1","extern":1,"intvolume":"        26","publication_status":"published","quality_controlled":0,"doi":"10.5802/jtnb.857","date_published":"2013-05-14T00:00:00Z"}]