[{"issue":"1","acknowledgement":"This work was supported by Solution-Oriented Research for Science and Technology from the Japan Science and Technology Agency; Ministry of Education, Culture, Sports, Science and Technology of Japan Grant 16300114 (to R.S.).","user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","intvolume":"       111","oa":1,"publication_status":"published","abstract":[{"lang":"eng","text":"Cerebellar motor learning is suggested to be caused by long-term plasticity of excitatory parallel fiber-Purkinje cell (PF-PC) synapses associated with changes in the number of synaptic AMPA-type glutamate receptors (AMPARs). However, whether the AMPARs decrease or increase in individual PF-PC synapses occurs in physiological motor learning and accounts for memory that lasts over days remains elusive. We combined quantitative SDS-digested freeze-fracture replica labeling for AMPAR and physical dissector electron microscopy with a simple model of cerebellar motor learning, adaptation of horizontal optokinetic response (HOKR) in mouse. After 1-h training of HOKR, short-term adaptation (STA) was accompanied with transient decrease in AMPARs by 28% in target PF-PC synapses. STA was well correlated with AMPAR decrease in individual animals and both STA and AMPAR decrease recovered to basal levels within 24 h. Surprisingly, long-termadaptation (LTA) after five consecutive daily trainings of 1-h HOKR did not alter the number of AMPARs in PF-PC synapses but caused gradual and persistent synapse elimination by 45%, with corresponding PC spine loss by the fifth training day. Furthermore, recovery of LTA after 2 wk was well correlated with increase of PF-PC synapses to the control level. Our findings indicate that the AMPARs decrease in PF-PC synapses and the elimination of these synapses are in vivo engrams in short- and long-term motor learning, respectively, showing a unique type of synaptic plasticity that may contribute to memory consolidation."}],"volume":111,"main_file_link":[{"url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890858/","open_access":"1"}],"publist_id":"5174","language":[{"iso":"eng"}],"status":"public","type":"journal_article","citation":{"ama":"Wang W, Nakadate K, Masugi Tokita M, et al. Distinct cerebellar engrams in short-term and long-term motor learning. <i>PNAS</i>. 2014;111(1):E188-E193. doi:<a href=\"https://doi.org/10.1073/pnas.1315541111\">10.1073/pnas.1315541111</a>","chicago":"Wang, Wen, Kazuhiko Nakadate, Miwako Masugi Tokita, Fumihiro Shutoh, Wajeeha Aziz, Etsuko Tarusawa, Andrea Lörincz, et al. “Distinct Cerebellar Engrams in Short-Term and Long-Term Motor Learning.” <i>PNAS</i>. National Academy of Sciences, 2014. <a href=\"https://doi.org/10.1073/pnas.1315541111\">https://doi.org/10.1073/pnas.1315541111</a>.","mla":"Wang, Wen, et al. “Distinct Cerebellar Engrams in Short-Term and Long-Term Motor Learning.” <i>PNAS</i>, vol. 111, no. 1, National Academy of Sciences, 2014, pp. E188–93, doi:<a href=\"https://doi.org/10.1073/pnas.1315541111\">10.1073/pnas.1315541111</a>.","ista":"Wang W, Nakadate K, Masugi Tokita M, Shutoh F, Aziz W, Tarusawa E, Lörincz A, Molnár E, Kesaf S, Li Y, Fukazawa Y, Nagao S, Shigemoto R. 2014. Distinct cerebellar engrams in short-term and long-term motor learning. PNAS. 111(1), E188–E193.","apa":"Wang, W., Nakadate, K., Masugi Tokita, M., Shutoh, F., Aziz, W., Tarusawa, E., … Shigemoto, R. (2014). Distinct cerebellar engrams in short-term and long-term motor learning. <i>PNAS</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.1315541111\">https://doi.org/10.1073/pnas.1315541111</a>","short":"W. Wang, K. Nakadate, M. Masugi Tokita, F. Shutoh, W. Aziz, E. Tarusawa, A. Lörincz, E. Molnár, S. Kesaf, Y. Li, Y. Fukazawa, S. Nagao, R. Shigemoto, PNAS 111 (2014) E188–E193.","ieee":"W. Wang <i>et al.</i>, “Distinct cerebellar engrams in short-term and long-term motor learning,” <i>PNAS</i>, vol. 111, no. 1. National Academy of Sciences, pp. E188–E193, 2014."},"scopus_import":1,"author":[{"first_name":"Wen","full_name":"Wang, Wen","last_name":"Wang"},{"full_name":"Nakadate, Kazuhiko","last_name":"Nakadate","first_name":"Kazuhiko"},{"first_name":"Miwako","full_name":"Masugi Tokita, Miwako","last_name":"Masugi Tokita"},{"first_name":"Fumihiro","full_name":"Shutoh, Fumihiro","last_name":"Shutoh"},{"full_name":"Aziz, Wajeeha","last_name":"Aziz","first_name":"Wajeeha"},{"first_name":"Etsuko","full_name":"Tarusawa, Etsuko","last_name":"Tarusawa"},{"last_name":"Lörincz","full_name":"Lörincz, Andrea","first_name":"Andrea"},{"first_name":"Elek","full_name":"Molnár, Elek","last_name":"Molnár"},{"last_name":"Kesaf","full_name":"Kesaf, Sebnem","id":"401AB46C-F248-11E8-B48F-1D18A9856A87","first_name":"Sebnem"},{"full_name":"Li, Yunqing","last_name":"Li","first_name":"Yunqing"},{"full_name":"Fukazawa, Yugo","last_name":"Fukazawa","first_name":"Yugo"},{"full_name":"Nagao, Soichi","last_name":"Nagao","first_name":"Soichi"},{"orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi","last_name":"Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi"}],"date_published":"2014-01-07T00:00:00Z","year":"2014","date_updated":"2021-01-12T06:54:05Z","title":"Distinct cerebellar engrams in short-term and long-term motor learning","department":[{"_id":"RySh"}],"month":"01","publisher":"National Academy of Sciences","_id":"1920","date_created":"2018-12-11T11:54:43Z","day":"07","doi":"10.1073/pnas.1315541111","publication":"PNAS","oa_version":"Submitted Version","page":"E188 - E193"},{"oa_version":"Submitted Version","doi":"10.1105/tpc.114.126185","day":"01","publisher":"American Society of Plant Biologists","department":[{"_id":"JiFr"}],"author":[{"last_name":"Tejos","full_name":"Tejos, Ricardo","first_name":"Ricardo"},{"full_name":"Sauer, Michael","last_name":"Sauer","first_name":"Michael"},{"first_name":"Steffen","last_name":"Vanneste","full_name":"Vanneste, Steffen"},{"first_name":"MiriamPalacios ","full_name":"Palacios-Gomez, MiriamPalacios ","last_name":"Palacios-Gomez"},{"first_name":"Hongjiang","id":"33CA54A6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5039-9660","full_name":"Li, Hongjiang","last_name":"Li"},{"full_name":"Heilmann, Mareike","last_name":"Heilmann","first_name":"Mareike"},{"first_name":"Ringo","full_name":"Van Wijk, Ringo","last_name":"Van Wijk"},{"last_name":"Vermeer","full_name":"Vermeer, Joop","first_name":"Joop"},{"first_name":"Ingo","full_name":"Heilmann, Ingo","last_name":"Heilmann"},{"first_name":"Teun","full_name":"Munnik, Teun","last_name":"Munnik"},{"first_name":"Jirí","id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml","orcid":"0000-0002-8302-7596","full_name":"Friml, Jirí"}],"year":"2014","type":"journal_article","citation":{"ista":"Tejos R, Sauer M, Vanneste S, Palacios-Gomez M, Li H, Heilmann M, Van Wijk R, Vermeer J, Heilmann I, Munnik T, Friml J. 2014. Bipolar plasma membrane distribution of phosphoinositides and their requirement for auxin-mediated cell polarity and patterning in Arabidopsis. Plant Cell. 26(5), 2114–2128.","mla":"Tejos, Ricardo, et al. “Bipolar Plasma Membrane Distribution of Phosphoinositides and Their Requirement for Auxin-Mediated Cell Polarity and Patterning in Arabidopsis.” <i>Plant Cell</i>, vol. 26, no. 5, American Society of Plant Biologists, 2014, pp. 2114–28, doi:<a href=\"https://doi.org/10.1105/tpc.114.126185\">10.1105/tpc.114.126185</a>.","ama":"Tejos R, Sauer M, Vanneste S, et al. Bipolar plasma membrane distribution of phosphoinositides and their requirement for auxin-mediated cell polarity and patterning in Arabidopsis. <i>Plant Cell</i>. 2014;26(5):2114-2128. doi:<a href=\"https://doi.org/10.1105/tpc.114.126185\">10.1105/tpc.114.126185</a>","chicago":"Tejos, Ricardo, Michael Sauer, Steffen Vanneste, MiriamPalacios  Palacios-Gomez, Hongjiang Li, Mareike Heilmann, Ringo Van Wijk, et al. “Bipolar Plasma Membrane Distribution of Phosphoinositides and Their Requirement for Auxin-Mediated Cell Polarity and Patterning in Arabidopsis.” <i>Plant Cell</i>. American Society of Plant Biologists, 2014. <a href=\"https://doi.org/10.1105/tpc.114.126185\">https://doi.org/10.1105/tpc.114.126185</a>.","ieee":"R. Tejos <i>et al.</i>, “Bipolar plasma membrane distribution of phosphoinositides and their requirement for auxin-mediated cell polarity and patterning in Arabidopsis,” <i>Plant Cell</i>, vol. 26, no. 5. American Society of Plant Biologists, pp. 2114–2128, 2014.","short":"R. Tejos, M. Sauer, S. Vanneste, M. Palacios-Gomez, H. Li, M. Heilmann, R. Van Wijk, J. Vermeer, I. Heilmann, T. Munnik, J. Friml, Plant Cell 26 (2014) 2114–2128.","apa":"Tejos, R., Sauer, M., Vanneste, S., Palacios-Gomez, M., Li, H., Heilmann, M., … Friml, J. (2014). Bipolar plasma membrane distribution of phosphoinositides and their requirement for auxin-mediated cell polarity and patterning in Arabidopsis. <i>Plant Cell</i>. American Society of Plant Biologists. <a href=\"https://doi.org/10.1105/tpc.114.126185\">https://doi.org/10.1105/tpc.114.126185</a>"},"language":[{"iso":"eng"}],"status":"public","abstract":[{"text":"Cell polarity manifested by asymmetric distribution of cargoes, such as receptors and transporters, within the plasma membrane (PM) is crucial for essential functions in multicellular organisms. In plants, cell polarity (re)establishment is intimately linked to patterning processes. Despite the importance of cell polarity, its underlying mechanisms are still largely unknown, including the definition and distinctiveness of the polar domains within the PM. Here, we show in Arabidopsis thaliana that the signaling membrane components, the phosphoinositides phosphatidylinositol 4-phosphate (PtdIns4P) and phosphatidylinositol 4, 5-bisphosphate [PtdIns(4, 5)P2] as well as PtdIns4P 5-kinases mediating their interconversion, are specifically enriched at apical and basal polar plasma membrane domains. The PtdIns4P 5-kinases PIP5K1 and PIP5K2 are redundantly required for polar localization of specifically apical and basal cargoes, such as PIN-FORMED transporters for the plant hormone auxin. As a consequence of the polarity defects, instructive auxin gradients as well as embryonic and postembryonic patterning are severely compromised. Furthermore, auxin itself regulates PIP5K transcription and PtdIns4P and PtdIns(4, 5)P2 levels, in particular their association with polar PM domains. Our results provide insight into the polar domain-delineating mechanisms in plant cells that depend on apical and basal distribution of membrane lipids and are essential for embryonic and postembryonic patterning.","lang":"eng"}],"publication_status":"published","publist_id":"5173","page":"2114 - 2128","publication":"Plant Cell","date_created":"2018-12-11T11:54:43Z","project":[{"name":"Polarity and subcellular dynamics in plants","grant_number":"282300","_id":"25716A02-B435-11E9-9278-68D0E5697425","call_identifier":"FP7"}],"_id":"1921","month":"05","date_updated":"2021-01-12T06:54:05Z","title":"Bipolar plasma membrane distribution of phosphoinositides and their requirement for auxin-mediated cell polarity and patterning in Arabidopsis","ec_funded":1,"date_published":"2014-05-01T00:00:00Z","scopus_import":1,"volume":26,"main_file_link":[{"url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079372/","open_access":"1"}],"issue":"5","user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","acknowledgement":"This work was supported by grants from the Odysseus program of the Research Foundation-Flanders (to J.F.).","oa":1,"intvolume":"        26"},{"oa_version":"None","page":"1398 - 1411","doi":"10.1111/nph.12751","publication":"New Phytologist","date_created":"2018-12-11T11:54:44Z","day":"01","_id":"1922","publisher":"Wiley-Blackwell","project":[{"name":"Hormonal cross-talk in plant organogenesis","call_identifier":"FP7","_id":"253FCA6A-B435-11E9-9278-68D0E5697425","grant_number":"207362"}],"month":"06","title":"Dynamic infrared imaging analysis of apical hook development in Arabidopsis: The case of brassinosteroids","date_updated":"2021-01-12T06:54:05Z","department":[{"_id":"EvBe"}],"ec_funded":1,"author":[{"full_name":"Smet, Dajo","last_name":"Smet","first_name":"Dajo"},{"first_name":"Petra","last_name":"Žádníková","full_name":"Žádníková, Petra"},{"full_name":"Vandenbussche, Filip","last_name":"Vandenbussche","first_name":"Filip"},{"first_name":"Eva","id":"38F4F166-F248-11E8-B48F-1D18A9856A87","last_name":"Benková","orcid":"0000-0002-8510-9739","full_name":"Benková, Eva"},{"first_name":"Dominique","full_name":"Van Der Straeten, Dominique","last_name":"Van Der Straeten"}],"date_published":"2014-06-01T00:00:00Z","year":"2014","type":"journal_article","citation":{"apa":"Smet, D., Žádníková, P., Vandenbussche, F., Benková, E., &#38; Van Der Straeten, D. (2014). Dynamic infrared imaging analysis of apical hook development in Arabidopsis: The case of brassinosteroids. <i>New Phytologist</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1111/nph.12751\">https://doi.org/10.1111/nph.12751</a>","short":"D. Smet, P. Žádníková, F. Vandenbussche, E. Benková, D. Van Der Straeten, New Phytologist 202 (2014) 1398–1411.","ieee":"D. Smet, P. Žádníková, F. Vandenbussche, E. Benková, and D. Van Der Straeten, “Dynamic infrared imaging analysis of apical hook development in Arabidopsis: The case of brassinosteroids,” <i>New Phytologist</i>, vol. 202, no. 4. Wiley-Blackwell, pp. 1398–1411, 2014.","ama":"Smet D, Žádníková P, Vandenbussche F, Benková E, Van Der Straeten D. Dynamic infrared imaging analysis of apical hook development in Arabidopsis: The case of brassinosteroids. <i>New Phytologist</i>. 2014;202(4):1398-1411. doi:<a href=\"https://doi.org/10.1111/nph.12751\">10.1111/nph.12751</a>","chicago":"Smet, Dajo, Petra Žádníková, Filip Vandenbussche, Eva Benková, and Dominique Van Der Straeten. “Dynamic Infrared Imaging Analysis of Apical Hook Development in Arabidopsis: The Case of Brassinosteroids.” <i>New Phytologist</i>. Wiley-Blackwell, 2014. <a href=\"https://doi.org/10.1111/nph.12751\">https://doi.org/10.1111/nph.12751</a>.","mla":"Smet, Dajo, et al. “Dynamic Infrared Imaging Analysis of Apical Hook Development in Arabidopsis: The Case of Brassinosteroids.” <i>New Phytologist</i>, vol. 202, no. 4, Wiley-Blackwell, 2014, pp. 1398–411, doi:<a href=\"https://doi.org/10.1111/nph.12751\">10.1111/nph.12751</a>.","ista":"Smet D, Žádníková P, Vandenbussche F, Benková E, Van Der Straeten D. 2014. Dynamic infrared imaging analysis of apical hook development in Arabidopsis: The case of brassinosteroids. New Phytologist. 202(4), 1398–1411."},"scopus_import":1,"language":[{"iso":"eng"}],"status":"public","volume":202,"abstract":[{"lang":"eng","text":"Germination of Arabidopsis seeds in darkness induces apical hook development, based on a tightly regulated differential growth coordinated by a multiple hormone cross-talk. Here, we endeavoured to clarify the function of brassinosteroids (BRs) and cross-talk with ethylene in hook development. An automated infrared imaging system was developed to study the kinetics of hook development in etiolated Arabidopsis seedlings. To ascertain the photomorphogenic control of hook opening, the system was equipped with an automatic light dimmer. We demonstrate that ethylene and BRs are indispensable for hook formation and maintenance. Ethylene regulation of hook formation functions partly through BRs, with BR feedback inhibition of ethylene action. Conversely, BR-mediated extension of hook maintenance functions partly through ethylene. Furthermore, we revealed that a short light pulse is sufficient to induce rapid hook opening. Our dynamic infrared imaging system allows high-resolution, kinetic imaging of up to 112 seedlings in a single experimental run. At this high throughput, it is ideally suited to rapidly gain insight in pathway networks. We demonstrate that BRs and ethylene cooperatively regulate apical hook development in a phase-dependent manner. Furthermore, we show that light is a predominant regulator of hook opening, inhibiting ethylene- and BR-mediated postponement of hook opening."}],"publication_status":"published","publist_id":"5172","issue":"4","user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","acknowledgement":"Funded by Ghent University; Research Foundation Flanders Grant Number: G065613N European Research Council Grant Number: CZ.1.07/2.3.00/20.0043","intvolume":"       202"},{"volume":16,"article_number":"065005","user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","oa":1,"intvolume":"        16","scopus_import":1,"title":"Active elastic thin shell theory for cellular deformations","date_updated":"2021-01-12T06:54:06Z","month":"06","date_published":"2014-06-01T00:00:00Z","file_date_updated":"2020-07-14T12:45:21Z","pubrep_id":"429","publication":"New Journal of Physics","_id":"1923","date_created":"2018-12-11T11:54:44Z","publication_status":"published","abstract":[{"lang":"eng","text":"We derive the equations for a thin, axisymmetric elastic shell subjected to an internal active stress giving rise to active tension and moments within the shell. We discuss the stability of a cylindrical elastic shell and its response to a localized change in internal active stress. This description is relevant to describe the cellular actomyosin cortex, a thin shell at the cell surface behaving elastically at a short timescale and subjected to active internal forces arising from myosin molecular motor activity. We show that the recent observations of cell deformation following detachment of adherent cells (Maître J-L et al 2012 Science 338 253-6) are well accounted for by this mechanical description. The actin cortex elastic and bending moduli can be obtained from a quantitative analysis of cell shapes observed in these experiments. Our approach thus provides a non-invasive, imaging-based method for the extraction of cellular physical parameters."}],"publist_id":"5171","language":[{"iso":"eng"}],"has_accepted_license":"1","status":"public","quality_controlled":"1","file":[{"relation":"main_file","checksum":"8dbe81ec656bf1264d8889bda9b2b985","file_size":941387,"content_type":"application/pdf","date_updated":"2020-07-14T12:45:21Z","file_name":"IST-2016-429-v1+1_document.pdf","access_level":"open_access","file_id":"5202","creator":"system","date_created":"2018-12-12T10:16:16Z"}],"type":"journal_article","citation":{"ieee":"H. Berthoumieux, J.-L. Maître, C.-P. J. Heisenberg, E. Paluch, F. Julicher, and G. Salbreux, “Active elastic thin shell theory for cellular deformations,” <i>New Journal of Physics</i>, vol. 16. IOP Publishing Ltd., 2014.","apa":"Berthoumieux, H., Maître, J.-L., Heisenberg, C.-P. J., Paluch, E., Julicher, F., &#38; Salbreux, G. (2014). Active elastic thin shell theory for cellular deformations. <i>New Journal of Physics</i>. IOP Publishing Ltd. <a href=\"https://doi.org/10.1088/1367-2630/16/6/065005\">https://doi.org/10.1088/1367-2630/16/6/065005</a>","short":"H. Berthoumieux, J.-L. Maître, C.-P.J. Heisenberg, E. Paluch, F. Julicher, G. Salbreux, New Journal of Physics 16 (2014).","mla":"Berthoumieux, Hélène, et al. “Active Elastic Thin Shell Theory for Cellular Deformations.” <i>New Journal of Physics</i>, vol. 16, 065005, IOP Publishing Ltd., 2014, doi:<a href=\"https://doi.org/10.1088/1367-2630/16/6/065005\">10.1088/1367-2630/16/6/065005</a>.","ista":"Berthoumieux H, Maître J-L, Heisenberg C-PJ, Paluch E, Julicher F, Salbreux G. 2014. Active elastic thin shell theory for cellular deformations. New Journal of Physics. 16, 065005.","ama":"Berthoumieux H, Maître J-L, Heisenberg C-PJ, Paluch E, Julicher F, Salbreux G. Active elastic thin shell theory for cellular deformations. <i>New Journal of Physics</i>. 2014;16. doi:<a href=\"https://doi.org/10.1088/1367-2630/16/6/065005\">10.1088/1367-2630/16/6/065005</a>","chicago":"Berthoumieux, Hélène, Jean-Léon Maître, Carl-Philipp J Heisenberg, Ewa Paluch, Frank Julicher, and Guillaume Salbreux. “Active Elastic Thin Shell Theory for Cellular Deformations.” <i>New Journal of Physics</i>. IOP Publishing Ltd., 2014. <a href=\"https://doi.org/10.1088/1367-2630/16/6/065005\">https://doi.org/10.1088/1367-2630/16/6/065005</a>."},"ddc":["570"],"department":[{"_id":"CaHe"}],"tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"author":[{"last_name":"Berthoumieux","full_name":"Berthoumieux, Hélène","first_name":"Hélène"},{"id":"48F1E0D8-F248-11E8-B48F-1D18A9856A87","first_name":"Jean-Léon","orcid":"0000-0002-3688-1474","full_name":"Maître, Jean-Léon","last_name":"Maître"},{"orcid":"0000-0002-0912-4566","full_name":"Heisenberg, Carl-Philipp J","last_name":"Heisenberg","first_name":"Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Paluch","full_name":"Paluch, Ewa","first_name":"Ewa"},{"first_name":"Frank","full_name":"Julicher, Frank","last_name":"Julicher"},{"last_name":"Salbreux","full_name":"Salbreux, Guillaume","first_name":"Guillaume"}],"year":"2014","doi":"10.1088/1367-2630/16/6/065005","oa_version":"Published Version","publisher":"IOP Publishing Ltd.","day":"01"},{"doi":"10.1038/ncomms4090","publication":"Nature Communications","oa_version":"None","publisher":"Nature Publishing Group","_id":"1924","date_created":"2018-12-11T11:54:44Z","day":"27","date_updated":"2021-01-12T06:54:06Z","title":"Auxin transport and activity regulate stomatal patterning and development","department":[{"_id":"JiFr"}],"month":"01","date_published":"2014-01-27T00:00:00Z","author":[{"first_name":"Jie","last_name":"Le","full_name":"Le, Jie"},{"first_name":"Xuguang","full_name":"Liu, Xuguang","last_name":"Liu"},{"first_name":"Kezhen","full_name":"Yang, Kezhen","last_name":"Yang"},{"last_name":"Chen","full_name":"Chen, Xiaolan","first_name":"Xiaolan"},{"first_name":"Lingling","full_name":"Zhu, Lingling","last_name":"Zhu"},{"first_name":"Hongzhe","full_name":"Wang, Hongzhe","last_name":"Wang"},{"full_name":"Wang, Ming","last_name":"Wang","first_name":"Ming"},{"first_name":"Steffen","full_name":"Vanneste, Steffen","last_name":"Vanneste"},{"last_name":"Morita","full_name":"Morita, Miyo","first_name":"Miyo"},{"full_name":"Tasaka, Masao","last_name":"Tasaka","first_name":"Masao"},{"first_name":"Zhaojun","last_name":"Ding","full_name":"Ding, Zhaojun"},{"first_name":"Jirí","id":"4159519E-F248-11E8-B48F-1D18A9856A87","full_name":"Friml, Jirí","orcid":"0000-0002-8302-7596","last_name":"Friml"},{"full_name":"Beeckman, Tom","last_name":"Beeckman","first_name":"Tom"},{"first_name":"Fred","last_name":"Sack","full_name":"Sack, Fred"}],"year":"2014","citation":{"mla":"Le, Jie, et al. “Auxin Transport and Activity Regulate Stomatal Patterning and Development.” <i>Nature Communications</i>, vol. 5, 3090, Nature Publishing Group, 2014, doi:<a href=\"https://doi.org/10.1038/ncomms4090\">10.1038/ncomms4090</a>.","ista":"Le J, Liu X, Yang K, Chen X, Zhu L, Wang H, Wang M, Vanneste S, Morita M, Tasaka M, Ding Z, Friml J, Beeckman T, Sack F. 2014. Auxin transport and activity regulate stomatal patterning and development. Nature Communications. 5, 3090.","ama":"Le J, Liu X, Yang K, et al. Auxin transport and activity regulate stomatal patterning and development. <i>Nature Communications</i>. 2014;5. doi:<a href=\"https://doi.org/10.1038/ncomms4090\">10.1038/ncomms4090</a>","chicago":"Le, Jie, Xuguang Liu, Kezhen Yang, Xiaolan Chen, Lingling Zhu, Hongzhe Wang, Ming Wang, et al. “Auxin Transport and Activity Regulate Stomatal Patterning and Development.” <i>Nature Communications</i>. Nature Publishing Group, 2014. <a href=\"https://doi.org/10.1038/ncomms4090\">https://doi.org/10.1038/ncomms4090</a>.","ieee":"J. Le <i>et al.</i>, “Auxin transport and activity regulate stomatal patterning and development,” <i>Nature Communications</i>, vol. 5. Nature Publishing Group, 2014.","apa":"Le, J., Liu, X., Yang, K., Chen, X., Zhu, L., Wang, H., … Sack, F. (2014). Auxin transport and activity regulate stomatal patterning and development. <i>Nature Communications</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/ncomms4090\">https://doi.org/10.1038/ncomms4090</a>","short":"J. Le, X. Liu, K. Yang, X. Chen, L. Zhu, H. Wang, M. Wang, S. Vanneste, M. Morita, M. Tasaka, Z. Ding, J. Friml, T. Beeckman, F. Sack, Nature Communications 5 (2014)."},"type":"journal_article","scopus_import":1,"publication_status":"published","abstract":[{"text":"Stomata are two-celled valves that control epidermal pores whose spacing optimizes shoot-atmosphere gas exchange. They develop from protodermal cells after unequal divisions followed by an equal division and differentiation. The concentration of the hormone auxin, a master plant developmental regulator, is tightly controlled in time and space, but its role, if any, in stomatal formation is obscure. Here dynamic changes of auxin activity during stomatal development are monitored using auxin input (DII-VENUS) and output (DR5:VENUS) markers by time-lapse imaging. A decrease in auxin levels in the smaller daughter cell after unequal division presages the acquisition of a guard mother cell fate whose equal division produces the two guard cells. Thus, stomatal patterning requires auxin pathway control of stem cell compartment size, as well as auxin depletion that triggers a developmental switch from unequal to equal division.","lang":"eng"}],"volume":5,"publist_id":"5170","language":[{"iso":"eng"}],"status":"public","article_number":"3090","quality_controlled":"1","user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","intvolume":"         5"},{"date_published":"2014-03-28T00:00:00Z","article_processing_charge":"No","date_updated":"2021-01-12T06:54:07Z","title":"A single-molecule approach to explore binding uptake and transport of cancer cell targeting nanotubes","month":"03","_id":"1925","date_created":"2018-12-11T11:54:45Z","file_date_updated":"2020-07-14T12:45:21Z","publication":"Nanotechnology","article_number":"125704","issue":"12","acknowledgement":"This work was supported by EC grant Marie Curie RTN-CT-2006-035616, CARBIO 'Carbon nanotubes for biomedical applications' and Austrian FFG grant mnt-era.net 823980, 'IntelliTip'.\r\n","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"intvolume":"        25","volume":25,"scopus_import":1,"author":[{"full_name":"Lamprecht, Constanze","last_name":"Lamprecht","first_name":"Constanze"},{"first_name":"Birgit","last_name":"Plochberger","full_name":"Plochberger, Birgit"},{"first_name":"Verena","id":"4D71A03A-F248-11E8-B48F-1D18A9856A87","last_name":"Ruprecht","orcid":"0000-0003-4088-8633","full_name":"Ruprecht, Verena"},{"first_name":"Stefan","id":"355AA5A0-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2670-2217","full_name":"Wieser, Stefan","last_name":"Wieser"},{"first_name":"Christian","last_name":"Rankl","full_name":"Rankl, Christian"},{"last_name":"Heister","full_name":"Heister, Elena","first_name":"Elena"},{"first_name":"Barbara","last_name":"Unterauer","full_name":"Unterauer, Barbara"},{"full_name":"Brameshuber, Mario","last_name":"Brameshuber","first_name":"Mario"},{"full_name":"Danzberger, Jürgen","last_name":"Danzberger","first_name":"Jürgen"},{"last_name":"Lukanov","full_name":"Lukanov, Petar","first_name":"Petar"},{"full_name":"Flahaut, Emmanuel","last_name":"Flahaut","first_name":"Emmanuel"},{"first_name":"Gerhard","last_name":"Schütz","full_name":"Schütz, Gerhard"},{"first_name":"Peter","last_name":"Hinterdorfer","full_name":"Hinterdorfer, Peter"},{"first_name":"Andreas","last_name":"Ebner","full_name":"Ebner, Andreas"}],"year":"2014","department":[{"_id":"CaHe"},{"_id":"MiSi"}],"publisher":"IOP Publishing","day":"28","doi":"10.1088/0957-4484/25/12/125704","oa_version":"Submitted Version","abstract":[{"lang":"eng","text":"In the past decade carbon nanotubes (CNTs) have been widely studied as a potential drug-delivery system, especially with functionality for cellular targeting. Yet, little is known about the actual process of docking to cell receptors and transport dynamics after internalization. Here we performed single-particle studies of folic acid (FA) mediated CNT binding to human carcinoma cells and their transport inside the cytosol. In particular, we employed molecular recognition force spectroscopy, an atomic force microscopy based method, to visualize and quantify docking of FA functionalized CNTs to FA binding receptors in terms of binding probability and binding force. We then traced individual fluorescently labeled, FA functionalized CNTs after specific uptake, and created a dynamic 'roadmap' that clearly showed trajectories of directed diffusion and areas of nanotube confinement in the cytosol. Our results demonstrate the potential of a single-molecule approach for investigation of drug-delivery vehicles and their targeting capacity."}],"publication_status":"published","publist_id":"5169","language":[{"iso":"eng"}],"has_accepted_license":"1","status":"public","ddc":["570"],"article_type":"original","file":[{"checksum":"df4e03d225a19179e7790f6d87a12332","relation":"main_file","date_updated":"2020-07-14T12:45:21Z","content_type":"application/pdf","file_size":3804152,"file_name":"2014_Nanotechnology_Lamprecht.pdf","access_level":"open_access","file_id":"7856","date_created":"2020-05-15T09:21:19Z","creator":"dernst"}],"type":"journal_article","citation":{"ieee":"C. Lamprecht <i>et al.</i>, “A single-molecule approach to explore binding uptake and transport of cancer cell targeting nanotubes,” <i>Nanotechnology</i>, vol. 25, no. 12. IOP Publishing, 2014.","short":"C. Lamprecht, B. Plochberger, V. Ruprecht, S. Wieser, C. Rankl, E. Heister, B. Unterauer, M. Brameshuber, J. Danzberger, P. Lukanov, E. Flahaut, G. Schütz, P. Hinterdorfer, A. Ebner, Nanotechnology 25 (2014).","apa":"Lamprecht, C., Plochberger, B., Ruprecht, V., Wieser, S., Rankl, C., Heister, E., … Ebner, A. (2014). A single-molecule approach to explore binding uptake and transport of cancer cell targeting nanotubes. <i>Nanotechnology</i>. IOP Publishing. <a href=\"https://doi.org/10.1088/0957-4484/25/12/125704\">https://doi.org/10.1088/0957-4484/25/12/125704</a>","ista":"Lamprecht C, Plochberger B, Ruprecht V, Wieser S, Rankl C, Heister E, Unterauer B, Brameshuber M, Danzberger J, Lukanov P, Flahaut E, Schütz G, Hinterdorfer P, Ebner A. 2014. A single-molecule approach to explore binding uptake and transport of cancer cell targeting nanotubes. Nanotechnology. 25(12), 125704.","mla":"Lamprecht, Constanze, et al. “A Single-Molecule Approach to Explore Binding Uptake and Transport of Cancer Cell Targeting Nanotubes.” <i>Nanotechnology</i>, vol. 25, no. 12, 125704, IOP Publishing, 2014, doi:<a href=\"https://doi.org/10.1088/0957-4484/25/12/125704\">10.1088/0957-4484/25/12/125704</a>.","ama":"Lamprecht C, Plochberger B, Ruprecht V, et al. A single-molecule approach to explore binding uptake and transport of cancer cell targeting nanotubes. <i>Nanotechnology</i>. 2014;25(12). doi:<a href=\"https://doi.org/10.1088/0957-4484/25/12/125704\">10.1088/0957-4484/25/12/125704</a>","chicago":"Lamprecht, Constanze, Birgit Plochberger, Verena Ruprecht, Stefan Wieser, Christian Rankl, Elena Heister, Barbara Unterauer, et al. “A Single-Molecule Approach to Explore Binding Uptake and Transport of Cancer Cell Targeting Nanotubes.” <i>Nanotechnology</i>. IOP Publishing, 2014. <a href=\"https://doi.org/10.1088/0957-4484/25/12/125704\">https://doi.org/10.1088/0957-4484/25/12/125704</a>."}},{"volume":17,"main_file_link":[{"url":"https://arxiv.org/abs/1304.3862","open_access":"1"}],"issue":"3-4","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"intvolume":"        17","scopus_import":1,"month":"12","date_updated":"2021-01-12T06:54:07Z","title":"Absolutely continuous spectrum for random Schrödinger operators on the Fibonacci and similar Tree-strips","ec_funded":1,"date_published":"2014-12-17T00:00:00Z","article_processing_charge":"No","page":"409 - 440","publication":"Mathematical Physics, Analysis and Geometry","date_created":"2018-12-11T11:54:45Z","external_id":{"arxiv":["1304.3862"]},"project":[{"name":"NSERC Postdoctoral fellowship","_id":"26450934-B435-11E9-9278-68D0E5697425"},{"name":"International IST Postdoc Fellowship Programme","grant_number":"291734","_id":"25681D80-B435-11E9-9278-68D0E5697425","call_identifier":"FP7"}],"_id":"1926","language":[{"iso":"eng"}],"status":"public","abstract":[{"lang":"eng","text":"We consider cross products of finite graphs with a class of trees that have arbitrarily but finitely long line segments, such as the Fibonacci tree. Such cross products are called tree-strips. We prove that for small disorder random Schrödinger operators on such tree-strips have purely absolutely continuous spectrum in a certain set."}],"publication_status":"published","publist_id":"5168","quality_controlled":"1","citation":{"ieee":"C. Sadel, “Absolutely continuous spectrum for random Schrödinger operators on the Fibonacci and similar Tree-strips,” <i>Mathematical Physics, Analysis and Geometry</i>, vol. 17, no. 3–4. Springer, pp. 409–440, 2014.","apa":"Sadel, C. (2014). Absolutely continuous spectrum for random Schrödinger operators on the Fibonacci and similar Tree-strips. <i>Mathematical Physics, Analysis and Geometry</i>. Springer. <a href=\"https://doi.org/10.1007/s11040-014-9163-4\">https://doi.org/10.1007/s11040-014-9163-4</a>","short":"C. Sadel, Mathematical Physics, Analysis and Geometry 17 (2014) 409–440.","ista":"Sadel C. 2014. Absolutely continuous spectrum for random Schrödinger operators on the Fibonacci and similar Tree-strips. Mathematical Physics, Analysis and Geometry. 17(3–4), 409–440.","mla":"Sadel, Christian. “Absolutely Continuous Spectrum for Random Schrödinger Operators on the Fibonacci and Similar Tree-Strips.” <i>Mathematical Physics, Analysis and Geometry</i>, vol. 17, no. 3–4, Springer, 2014, pp. 409–40, doi:<a href=\"https://doi.org/10.1007/s11040-014-9163-4\">10.1007/s11040-014-9163-4</a>.","ama":"Sadel C. Absolutely continuous spectrum for random Schrödinger operators on the Fibonacci and similar Tree-strips. <i>Mathematical Physics, Analysis and Geometry</i>. 2014;17(3-4):409-440. doi:<a href=\"https://doi.org/10.1007/s11040-014-9163-4\">10.1007/s11040-014-9163-4</a>","chicago":"Sadel, Christian. “Absolutely Continuous Spectrum for Random Schrödinger Operators on the Fibonacci and Similar Tree-Strips.” <i>Mathematical Physics, Analysis and Geometry</i>. Springer, 2014. <a href=\"https://doi.org/10.1007/s11040-014-9163-4\">https://doi.org/10.1007/s11040-014-9163-4</a>."},"type":"journal_article","article_type":"original","department":[{"_id":"LaEr"}],"author":[{"last_name":"Sadel","orcid":"0000-0001-8255-3968","full_name":"Sadel, Christian","id":"4760E9F8-F248-11E8-B48F-1D18A9856A87","first_name":"Christian"}],"year":"2014","arxiv":1,"oa_version":"Preprint","doi":"10.1007/s11040-014-9163-4","day":"17","publisher":"Springer"},{"intvolume":"      8874","oa":1,"acknowledgement":"We are grateful to Mihir Bellare for his feedback on earlier versions of this paper. We are indebted to Vanishree Rao for her generous assistance in preparing this proceedings version.","quality_controlled":0,"status":"public","main_file_link":[{"url":"http://eprint.iacr.org/2014/416","open_access":"1"}],"publist_id":"5167","abstract":[{"text":"Constrained pseudorandom functions have recently been introduced independently by Boneh and Waters (Asiacrypt’13), Kiayias et al. (CCS’13), and Boyle et al. (PKC’14). In a standard pseudorandom function (PRF) a key k is used to evaluate the PRF on all inputs in the domain. Constrained PRFs additionally offer the functionality to delegate “constrained” keys kS which allow to evaluate the PRF only on a subset S of the domain. The three above-mentioned papers all show that the classical GGM construction (J.ACM’86) of a PRF from a pseudorandom generator (PRG) directly yields a constrained PRF where one can compute constrained keys to evaluate the PRF on all inputs with a given prefix. This constrained PRF has already found many interesting applications. Unfortunately, the existing security proofs only show selective security (by a reduction to the security of the underlying PRG). To achieve full security, one has to use complexity leveraging, which loses an exponential factor 2N in security, where N is the input length. The first contribution of this paper is a new reduction that only loses a quasipolynomial factor qlog N, where q is the number of adversarial queries. For this we develop a new proof technique which constructs a distinguisher by interleaving simple guessing steps and hybrid arguments a small number of times. This approach might be of interest also in other contexts where currently the only technique to achieve full security is complexity leveraging. Our second contribution is concerned with another constrained PRF, due to Boneh and Waters, which allows for constrained keys for the more general class of bit-fixing functions. Their security proof also suffers from a 2N loss, which we show is inherent. We construct a meta-reduction which shows that any “simple” reduction of full security from a noninteractive hardness assumption must incur an exponential security loss.","lang":"eng"}],"publication_status":"published","volume":8874,"extern":1,"type":"conference","citation":{"ieee":"G. Fuchsbauer, M. Konstantinov, K. Z. Pietrzak, and V. Rao, “Adaptive security of constrained PRFs,” presented at the Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), 2014, vol. 8874, pp. 173–192.","apa":"Fuchsbauer, G., Konstantinov, M., Pietrzak, K. Z., &#38; Rao, V. (2014). Adaptive security of constrained PRFs (Vol. 8874, pp. 173–192). Presented at the Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), Springer. <a href=\"https://doi.org/10.1145/2591796.2591825\">https://doi.org/10.1145/2591796.2591825</a>","short":"G. Fuchsbauer, M. Konstantinov, K.Z. Pietrzak, V. Rao, in:, Springer, 2014, pp. 173–192.","ista":"Fuchsbauer G, Konstantinov M, Pietrzak KZ, Rao V. 2014. Adaptive security of constrained PRFs. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) vol. 8874, 173–192.","mla":"Fuchsbauer, Georg, et al. <i>Adaptive Security of Constrained PRFs</i>. Vol. 8874, Springer, 2014, pp. 173–92, doi:<a href=\"https://doi.org/10.1145/2591796.2591825\">10.1145/2591796.2591825</a>.","ama":"Fuchsbauer G, Konstantinov M, Pietrzak KZ, Rao V. Adaptive security of constrained PRFs. In: Vol 8874. Springer; 2014:173-192. doi:<a href=\"https://doi.org/10.1145/2591796.2591825\">10.1145/2591796.2591825</a>","chicago":"Fuchsbauer, Georg, Momchil Konstantinov, Krzysztof Z Pietrzak, and Vanishree Rao. “Adaptive Security of Constrained PRFs,” 8874:173–92. Springer, 2014. <a href=\"https://doi.org/10.1145/2591796.2591825\">https://doi.org/10.1145/2591796.2591825</a>."},"conference":{"name":"Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)"},"year":"2014","author":[{"first_name":"Georg","id":"46B4C3EE-F248-11E8-B48F-1D18A9856A87","last_name":"Fuchsbauer","full_name":"Georg Fuchsbauer"},{"first_name":"Momchil","full_name":"Konstantinov, Momchil","last_name":"Konstantinov"},{"id":"3E04A7AA-F248-11E8-B48F-1D18A9856A87","first_name":"Krzysztof Z","full_name":"Krzysztof Pietrzak","orcid":"0000-0002-9139-1654","last_name":"Pietrzak"},{"first_name":"Vanishree","full_name":"Rao, Vanishree","last_name":"Rao"}],"date_published":"2014-01-01T00:00:00Z","month":"01","title":"Adaptive security of constrained PRFs","date_updated":"2021-01-12T06:54:08Z","day":"01","date_created":"2018-12-11T11:54:45Z","_id":"1927","publisher":"Springer","page":"173 - 192","doi":"10.1145/2591796.2591825"},{"citation":{"ama":"Humplik J, Hill A, Nowak M. Evolutionary dynamics of infectious diseases in finite populations. <i>Journal of Theoretical Biology</i>. 2014;360:149-162. doi:<a href=\"https://doi.org/10.1016/j.jtbi.2014.06.039\">10.1016/j.jtbi.2014.06.039</a>","chicago":"Humplik, Jan, Alison Hill, and Martin Nowak. “Evolutionary Dynamics of Infectious Diseases in Finite Populations.” <i>Journal of Theoretical Biology</i>. Elsevier, 2014. <a href=\"https://doi.org/10.1016/j.jtbi.2014.06.039\">https://doi.org/10.1016/j.jtbi.2014.06.039</a>.","ista":"Humplik J, Hill A, Nowak M. 2014. Evolutionary dynamics of infectious diseases in finite populations. Journal of Theoretical Biology. 360, 149–162.","mla":"Humplik, Jan, et al. “Evolutionary Dynamics of Infectious Diseases in Finite Populations.” <i>Journal of Theoretical Biology</i>, vol. 360, Elsevier, 2014, pp. 149–62, doi:<a href=\"https://doi.org/10.1016/j.jtbi.2014.06.039\">10.1016/j.jtbi.2014.06.039</a>.","short":"J. Humplik, A. Hill, M. Nowak, Journal of Theoretical Biology 360 (2014) 149–162.","apa":"Humplik, J., Hill, A., &#38; Nowak, M. (2014). Evolutionary dynamics of infectious diseases in finite populations. <i>Journal of Theoretical Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.jtbi.2014.06.039\">https://doi.org/10.1016/j.jtbi.2014.06.039</a>","ieee":"J. Humplik, A. Hill, and M. Nowak, “Evolutionary dynamics of infectious diseases in finite populations,” <i>Journal of Theoretical Biology</i>, vol. 360. Elsevier, pp. 149–162, 2014."},"scopus_import":1,"type":"journal_article","intvolume":"       360","user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","acknowledgement":"J.H. received support from the Zdenek Bakala Foundation and the Mobility Fund of Charles University in Prague.","publist_id":"5166","publication_status":"published","abstract":[{"text":"In infectious disease epidemiology the basic reproductive ratio, R0, is defined as the average number of new infections caused by a single infected individual in a fully susceptible population. Many models describing competition for hosts between non-interacting pathogen strains in an infinite population lead to the conclusion that selection favors invasion of new strains if and only if they have higher R0 values than the resident. Here we demonstrate that this picture fails in finite populations. Using a simple stochastic SIS model, we show that in general there is no analogous optimization principle. We find that successive invasions may in some cases lead to strains that infect a smaller fraction of the host population, and that mutually invasible pathogen strains exist. In the limit of weak selection we demonstrate that an optimization principle does exist, although it differs from R0 maximization. For strains with very large R0, we derive an expression for this local fitness function and use it to establish a lower bound for the error caused by neglecting stochastic effects. Furthermore, we apply this weak selection limit to investigate the selection dynamics in the presence of a trade-off between the virulence and the transmission rate of a pathogen.","lang":"eng"}],"volume":360,"status":"public","language":[{"iso":"eng"}],"publisher":"Elsevier","_id":"1928","day":"07","date_created":"2018-12-11T11:54:46Z","doi":"10.1016/j.jtbi.2014.06.039","publication":"Journal of Theoretical Biology","page":"149 - 162","oa_version":"None","year":"2014","date_published":"2014-11-07T00:00:00Z","author":[{"id":"2E9627A8-F248-11E8-B48F-1D18A9856A87","first_name":"Jan","last_name":"Humplik","full_name":"Humplik, Jan"},{"first_name":"Alison","last_name":"Hill","full_name":"Hill, Alison"},{"last_name":"Nowak","full_name":"Nowak, Martin","first_name":"Martin"}],"department":[{"_id":"GaTk"}],"date_updated":"2021-01-12T06:54:08Z","title":"Evolutionary dynamics of infectious diseases in finite populations","month":"11"},{"intvolume":"       203","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","issue":"6","acknowledgement":"We would like to offer our special thanks to students of the Department of Mathematics of Demidov Yaroslavl State University A. A. Gorokhov and V. N. Knyazev for participation in developing the program and assistance in preparation of test data. This work was supported by grant 11.G34.31.0053 from the government of the Russian Federation.","volume":203,"scopus_import":"1","article_processing_charge":"No","date_published":"2014-11-16T00:00:00Z","date_updated":"2022-05-24T10:39:06Z","title":"An algorithm for cartographic generalization that preserves global topology","month":"11","_id":"1929","date_created":"2018-12-11T11:54:46Z","publication":"Journal of Mathematical Sciences","page":"754 - 760","quality_controlled":"1","publist_id":"5165","publication_status":"published","abstract":[{"lang":"eng","text":"We propose an algorithm for the generalization of cartographic objects that can be used to represent maps on different scales."}],"status":"public","language":[{"iso":"eng"}],"article_type":"original","citation":{"apa":"Alexeev, V. V., Bogaevskaya, V. G., Preobrazhenskaya, M. M., Ukhalov, A. Y., Edelsbrunner, H., &#38; Yakimova, O. (2014). An algorithm for cartographic generalization that preserves global topology. <i>Journal of Mathematical Sciences</i>. Springer. <a href=\"https://doi.org/10.1007/s10958-014-2165-8\">https://doi.org/10.1007/s10958-014-2165-8</a>","short":"V.V. Alexeev, V.G. Bogaevskaya, M.M. Preobrazhenskaya, A.Y. Ukhalov, H. Edelsbrunner, O. Yakimova, Journal of Mathematical Sciences 203 (2014) 754–760.","ieee":"V. V. Alexeev, V. G. Bogaevskaya, M. M. Preobrazhenskaya, A. Y. Ukhalov, H. Edelsbrunner, and O. Yakimova, “An algorithm for cartographic generalization that preserves global topology,” <i>Journal of Mathematical Sciences</i>, vol. 203, no. 6. Springer, pp. 754–760, 2014.","chicago":"Alexeev, V V, V G Bogaevskaya, M M Preobrazhenskaya, A Y Ukhalov, Herbert Edelsbrunner, and Olga Yakimova. “An Algorithm for Cartographic Generalization That Preserves Global Topology.” <i>Journal of Mathematical Sciences</i>. Springer, 2014. <a href=\"https://doi.org/10.1007/s10958-014-2165-8\">https://doi.org/10.1007/s10958-014-2165-8</a>.","ama":"Alexeev VV, Bogaevskaya VG, Preobrazhenskaya MM, Ukhalov AY, Edelsbrunner H, Yakimova O. An algorithm for cartographic generalization that preserves global topology. <i>Journal of Mathematical Sciences</i>. 2014;203(6):754-760. doi:<a href=\"https://doi.org/10.1007/s10958-014-2165-8\">10.1007/s10958-014-2165-8</a>","ista":"Alexeev VV, Bogaevskaya VG, Preobrazhenskaya MM, Ukhalov AY, Edelsbrunner H, Yakimova O. 2014. An algorithm for cartographic generalization that preserves global topology. Journal of Mathematical Sciences. 203(6), 754–760.","mla":"Alexeev, V. V., et al. “An Algorithm for Cartographic Generalization That Preserves Global Topology.” <i>Journal of Mathematical Sciences</i>, vol. 203, no. 6, Springer, 2014, pp. 754–60, doi:<a href=\"https://doi.org/10.1007/s10958-014-2165-8\">10.1007/s10958-014-2165-8</a>."},"type":"journal_article","year":"2014","author":[{"last_name":"Alexeev","full_name":"Alexeev, V V","first_name":"V V"},{"first_name":"V G","last_name":"Bogaevskaya","full_name":"Bogaevskaya, V G"},{"first_name":"M M","last_name":"Preobrazhenskaya","full_name":"Preobrazhenskaya, M M"},{"full_name":"Ukhalov, A Y","last_name":"Ukhalov","first_name":"A Y"},{"orcid":"0000-0002-9823-6833","full_name":"Edelsbrunner, Herbert","last_name":"Edelsbrunner","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","first_name":"Herbert"},{"first_name":"Olga","last_name":"Yakimova","full_name":"Yakimova, Olga"}],"publication_identifier":{"issn":["1072-3374"],"eissn":["1573-8795"]},"department":[{"_id":"HeEd"}],"publisher":"Springer","day":"16","doi":"10.1007/s10958-014-2165-8","oa_version":"None"},{"status":"public","language":[{"iso":"eng"}],"publist_id":"5164","abstract":[{"text":"(Figure Presented) Data acquisition, numerical inaccuracies, and sampling often introduce noise in measurements and simulations. Removing this noise is often necessary for efficient analysis and visualization of this data, yet many denoising techniques change the minima and maxima of a scalar field. For example, the extrema can appear or disappear, spatially move, and change their value. This can lead to wrong interpretations of the data, e.g., when the maximum temperature over an area is falsely reported being a few degrees cooler because the denoising method is unaware of these features. Recently, a topological denoising technique based on a global energy optimization was proposed, which allows the topology-controlled denoising of 2D scalar fields. While this method preserves the minima and maxima, it is constrained by the size of the data. We extend this work to large 2D data and medium-sized 3D data by introducing a novel domain decomposition approach. It allows processing small patches of the domain independently while still avoiding the introduction of new critical points. Furthermore, we propose an iterative refinement of the solution, which decreases the optimization energy compared to the previous approach and therefore gives smoother results that are closer to the input. We illustrate our technique on synthetic and real-world 2D and 3D data sets that highlight potential applications.","lang":"eng"}],"publication_status":"published","volume":20,"intvolume":"        20","issue":"12","user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","acknowledgement":"RTRA Digiteoproject; ERC grant; SNF award; Intel Doctoral Fellowship; MPC-VCC","quality_controlled":"1","citation":{"ieee":"D. Günther, A. Jacobson, J. Reininghaus, H. Seidel, O. Sorkine Hornung, and T. Weinkauf, “Fast and memory-efficient topological denoising of 2D and 3D scalar fields,” <i>IEEE Transactions on Visualization and Computer Graphics</i>, vol. 20, no. 12. IEEE, pp. 2585–2594, 2014.","apa":"Günther, D., Jacobson, A., Reininghaus, J., Seidel, H., Sorkine Hornung, O., &#38; Weinkauf, T. (2014). Fast and memory-efficient topological denoising of 2D and 3D scalar fields. <i>IEEE Transactions on Visualization and Computer Graphics</i>. IEEE. <a href=\"https://doi.org/10.1109/TVCG.2014.2346432\">https://doi.org/10.1109/TVCG.2014.2346432</a>","short":"D. Günther, A. Jacobson, J. Reininghaus, H. Seidel, O. Sorkine Hornung, T. Weinkauf, IEEE Transactions on Visualization and Computer Graphics 20 (2014) 2585–2594.","mla":"Günther, David, et al. “Fast and Memory-Efficient Topological Denoising of 2D and 3D Scalar Fields.” <i>IEEE Transactions on Visualization and Computer Graphics</i>, vol. 20, no. 12, IEEE, 2014, pp. 2585–94, doi:<a href=\"https://doi.org/10.1109/TVCG.2014.2346432\">10.1109/TVCG.2014.2346432</a>.","ista":"Günther D, Jacobson A, Reininghaus J, Seidel H, Sorkine Hornung O, Weinkauf T. 2014. Fast and memory-efficient topological denoising of 2D and 3D scalar fields. IEEE Transactions on Visualization and Computer Graphics. 20(12), 2585–2594.","chicago":"Günther, David, Alec Jacobson, Jan Reininghaus, Hans Seidel, Olga Sorkine Hornung, and Tino Weinkauf. “Fast and Memory-Efficient Topological Denoising of 2D and 3D Scalar Fields.” <i>IEEE Transactions on Visualization and Computer Graphics</i>. IEEE, 2014. <a href=\"https://doi.org/10.1109/TVCG.2014.2346432\">https://doi.org/10.1109/TVCG.2014.2346432</a>.","ama":"Günther D, Jacobson A, Reininghaus J, Seidel H, Sorkine Hornung O, Weinkauf T. Fast and memory-efficient topological denoising of 2D and 3D scalar fields. <i>IEEE Transactions on Visualization and Computer Graphics</i>. 2014;20(12):2585-2594. doi:<a href=\"https://doi.org/10.1109/TVCG.2014.2346432\">10.1109/TVCG.2014.2346432</a>"},"scopus_import":1,"type":"journal_article","month":"12","department":[{"_id":"HeEd"}],"title":"Fast and memory-efficient topological denoising of 2D and 3D scalar fields","date_updated":"2021-01-12T06:54:09Z","year":"2014","date_published":"2014-12-31T00:00:00Z","author":[{"first_name":"David","last_name":"Günther","full_name":"Günther, David"},{"last_name":"Jacobson","full_name":"Jacobson, Alec","first_name":"Alec"},{"full_name":"Reininghaus, Jan","last_name":"Reininghaus","first_name":"Jan","id":"4505473A-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Seidel, Hans","last_name":"Seidel","first_name":"Hans"},{"last_name":"Sorkine Hornung","full_name":"Sorkine Hornung, Olga","first_name":"Olga"},{"first_name":"Tino","last_name":"Weinkauf","full_name":"Weinkauf, Tino"}],"oa_version":"None","page":"2585 - 2594","publication":"IEEE Transactions on Visualization and Computer Graphics","doi":"10.1109/TVCG.2014.2346432","day":"31","date_created":"2018-12-11T11:54:46Z","publisher":"IEEE","_id":"1930"},{"_id":"1931","date_created":"2018-12-11T11:54:46Z","publication":"Frontiers in Computational Neuroscience","date_published":"2014-05-28T00:00:00Z","title":"Emergence of task-dependent representations in working memory circuits","date_updated":"2021-01-12T06:54:09Z","month":"05","scopus_import":1,"article_number":"57","oa":1,"intvolume":"         8","issue":"MAY","user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","acknowledgement":"Supported in part by EC MEXT project PLICON and the LOEWE-Program “Neuronal Coordination Research Focus Frankfurt” (NeFF). Jochen Triesch was supported by the Quandt foundation.","main_file_link":[{"open_access":"1","url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035833/"}],"volume":8,"publisher":"Frontiers Research Foundation","day":"28","doi":"10.3389/fncom.2014.00057","oa_version":"Submitted Version","year":"2014","author":[{"id":"3933349E-F248-11E8-B48F-1D18A9856A87","first_name":"Cristina","full_name":"Savin, Cristina","last_name":"Savin"},{"first_name":"Jochen","last_name":"Triesch","full_name":"Triesch, Jochen"}],"department":[{"_id":"GaTk"}],"citation":{"ama":"Savin C, Triesch J. Emergence of task-dependent representations in working memory circuits. <i>Frontiers in Computational Neuroscience</i>. 2014;8(MAY). doi:<a href=\"https://doi.org/10.3389/fncom.2014.00057\">10.3389/fncom.2014.00057</a>","chicago":"Savin, Cristina, and Jochen Triesch. “Emergence of Task-Dependent Representations in Working Memory Circuits.” <i>Frontiers in Computational Neuroscience</i>. Frontiers Research Foundation, 2014. <a href=\"https://doi.org/10.3389/fncom.2014.00057\">https://doi.org/10.3389/fncom.2014.00057</a>.","ista":"Savin C, Triesch J. 2014. Emergence of task-dependent representations in working memory circuits. Frontiers in Computational Neuroscience. 8(MAY), 57.","mla":"Savin, Cristina, and Jochen Triesch. “Emergence of Task-Dependent Representations in Working Memory Circuits.” <i>Frontiers in Computational Neuroscience</i>, vol. 8, no. MAY, 57, Frontiers Research Foundation, 2014, doi:<a href=\"https://doi.org/10.3389/fncom.2014.00057\">10.3389/fncom.2014.00057</a>.","apa":"Savin, C., &#38; Triesch, J. (2014). Emergence of task-dependent representations in working memory circuits. <i>Frontiers in Computational Neuroscience</i>. Frontiers Research Foundation. <a href=\"https://doi.org/10.3389/fncom.2014.00057\">https://doi.org/10.3389/fncom.2014.00057</a>","short":"C. Savin, J. Triesch, Frontiers in Computational Neuroscience 8 (2014).","ieee":"C. Savin and J. Triesch, “Emergence of task-dependent representations in working memory circuits,” <i>Frontiers in Computational Neuroscience</i>, vol. 8, no. MAY. Frontiers Research Foundation, 2014."},"type":"journal_article","quality_controlled":"1","publist_id":"5163","publication_status":"published","abstract":[{"lang":"eng","text":"A wealth of experimental evidence suggests that working memory circuits preferentially represent information that is behaviorally relevant. Still, we are missing a mechanistic account of how these representations come about. Here we provide a simple explanation for a range of experimental findings, in light of prefrontal circuits adapting to task constraints by reward-dependent learning. In particular, we model a neural network shaped by reward-modulated spike-timing dependent plasticity (r-STDP) and homeostatic plasticity (intrinsic excitability and synaptic scaling). We show that the experimentally-observed neural representations naturally emerge in an initially unstructured circuit as it learns to solve several working memory tasks. These results point to a critical, and previously unappreciated, role for reward-dependent learning in shaping prefrontal cortex activity."}],"status":"public","language":[{"iso":"eng"}]},{"issue":"12","user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","acknowledgement":"Funded by National Institutes of Health. Grant Numbers: R01GM076041, R01GM104040         \r\n\r\nSimons Foundation\r\n\r\n","intvolume":"        68","oa":1,"volume":68,"main_file_link":[{"url":"http://arxiv.org/abs/1310.6077","open_access":"1"}],"scopus_import":1,"date_published":"2014-12-01T00:00:00Z","ec_funded":1,"title":"Cryptic genetic variation can make &quot;irreducible complexity&quot; a common mode of adaptation in sexual populations","date_updated":"2021-01-12T06:54:10Z","month":"12","project":[{"name":"Limits to selection in biology and in evolutionary computation","call_identifier":"FP7","grant_number":"250152","_id":"25B07788-B435-11E9-9278-68D0E5697425"}],"_id":"1932","date_created":"2018-12-11T11:54:47Z","publication":"Evolution","page":"3357 - 3367","quality_controlled":"1","publication_status":"published","abstract":[{"lang":"eng","text":"The existence of complex (multiple-step) genetic adaptations that are &quot;irreducible&quot; (i.e., all partial combinations are less fit than the original genotype) is one of the longest standing problems in evolutionary biology. In standard genetics parlance, these adaptations require the crossing of a wide adaptive valley of deleterious intermediate stages. Here, we demonstrate, using a simple model, that evolution can cross wide valleys to produce &quot;irreducibly complex&quot; adaptations by making use of previously cryptic mutations. When revealed by an evolutionary capacitor, previously cryptic mutants have higher initial frequencies than do new mutations, bringing them closer to a valley-crossing saddle in allele frequency space. Moreover, simple combinatorics implies an enormous number of candidate combinations exist within available cryptic genetic variation. We model the dynamics of crossing of a wide adaptive valley after a capacitance event using both numerical simulations and analytical approximations. Although individual valley crossing events become less likely as valleys widen, by taking the combinatorics of genotype space into account, we see that revealing cryptic variation can cause the frequent evolution of complex adaptations."}],"publist_id":"5162","language":[{"iso":"eng"}],"status":"public","type":"journal_article","citation":{"apa":"Trotter, M., Weissman, D., Peterson, G., Peck, K., &#38; Masel, J. (2014). Cryptic genetic variation can make &#38;quot;irreducible complexity&#38;quot; a common mode of adaptation in sexual populations. <i>Evolution</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1111/evo.12517\">https://doi.org/10.1111/evo.12517</a>","short":"M. Trotter, D. Weissman, G. Peterson, K. Peck, J. Masel, Evolution 68 (2014) 3357–3367.","ieee":"M. Trotter, D. Weissman, G. Peterson, K. Peck, and J. Masel, “Cryptic genetic variation can make &#38;quot;irreducible complexity&#38;quot; a common mode of adaptation in sexual populations,” <i>Evolution</i>, vol. 68, no. 12. Wiley-Blackwell, pp. 3357–3367, 2014.","chicago":"Trotter, Meredith, Daniel Weissman, Grant Peterson, Kayla Peck, and Joanna Masel. “Cryptic Genetic Variation Can Make &#38;quot;Irreducible Complexity&#38;quot; a Common Mode of Adaptation in Sexual Populations.” <i>Evolution</i>. Wiley-Blackwell, 2014. <a href=\"https://doi.org/10.1111/evo.12517\">https://doi.org/10.1111/evo.12517</a>.","ama":"Trotter M, Weissman D, Peterson G, Peck K, Masel J. Cryptic genetic variation can make &#38;quot;irreducible complexity&#38;quot; a common mode of adaptation in sexual populations. <i>Evolution</i>. 2014;68(12):3357-3367. doi:<a href=\"https://doi.org/10.1111/evo.12517\">10.1111/evo.12517</a>","mla":"Trotter, Meredith, et al. “Cryptic Genetic Variation Can Make &#38;quot;Irreducible Complexity&#38;quot; a Common Mode of Adaptation in Sexual Populations.” <i>Evolution</i>, vol. 68, no. 12, Wiley-Blackwell, 2014, pp. 3357–67, doi:<a href=\"https://doi.org/10.1111/evo.12517\">10.1111/evo.12517</a>.","ista":"Trotter M, Weissman D, Peterson G, Peck K, Masel J. 2014. Cryptic genetic variation can make &#38;quot;irreducible complexity&#38;quot; a common mode of adaptation in sexual populations. Evolution. 68(12), 3357–3367."},"author":[{"full_name":"Trotter, Meredith","last_name":"Trotter","first_name":"Meredith"},{"first_name":"Daniel","id":"2D0CE020-F248-11E8-B48F-1D18A9856A87","last_name":"Weissman","full_name":"Weissman, Daniel"},{"full_name":"Peterson, Grant","last_name":"Peterson","first_name":"Grant"},{"first_name":"Kayla","full_name":"Peck, Kayla","last_name":"Peck"},{"first_name":"Joanna","full_name":"Masel, Joanna","last_name":"Masel"}],"year":"2014","department":[{"_id":"NiBa"}],"publisher":"Wiley-Blackwell","day":"01","doi":"10.1111/evo.12517","oa_version":"Submitted Version"},{"date_published":"2014-04-01T00:00:00Z","author":[{"first_name":"Jun","last_name":"Hatakeyama","full_name":"Hatakeyama, Jun"},{"full_name":"Wakamatsu, Yoshio","last_name":"Wakamatsu","first_name":"Yoshio"},{"full_name":"Nagafuchi, Akira","last_name":"Nagafuchi","first_name":"Akira"},{"last_name":"Kageyama","full_name":"Kageyama, Ryoichiro","first_name":"Ryoichiro"},{"first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444"},{"first_name":"Kenji","last_name":"Shimamura","full_name":"Shimamura, Kenji"}],"year":"2014","month":"04","title":"Cadherin-based adhesions in the apical endfoot are required for active Notch signaling to control neurogenesis in vertebrates","date_updated":"2021-01-12T06:54:10Z","department":[{"_id":"RySh"}],"date_created":"2018-12-11T11:54:47Z","day":"01","_id":"1933","publisher":"Company of Biologists","oa_version":"None","page":"1671 - 1682","publication":"Development","doi":"10.1242/dev.102988","issue":"8","user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","intvolume":"       141","quality_controlled":"1","language":[{"iso":"eng"}],"status":"public","abstract":[{"lang":"eng","text":"The development of the vertebrate brain requires an exquisite balance between proliferation and differentiation of neural progenitors. Notch signaling plays a pivotal role in regulating this balance, yet the interaction between signaling and receiving cells remains poorly understood. We have found that numerous nascent neurons and/or intermediate neurogenic progenitors expressing the ligand of Notch retain apical endfeet transiently at the ventricular lumen that form adherens junctions (AJs) with the endfeet of progenitors. Forced detachment of the apical endfeet of those differentiating cells by disrupting AJs resulted in precocious neurogenesis that was preceded by the downregulation of Notch signaling. Both Notch1 and its ligand Dll1 are distributed around AJs in the apical endfeet, and these proteins physically interact with ZO-1, a constituent of the AJ. Furthermore, live imaging of a fluorescently tagged Notch1 demonstrated its trafficking from the apical endfoot to the nucleus upon cleavage. Our results identified the apical endfoot as the central site of active Notch signaling to securely prohibit inappropriate differentiation of neural progenitors."}],"volume":141,"publication_status":"published","publist_id":"5161","type":"journal_article","citation":{"ista":"Hatakeyama J, Wakamatsu Y, Nagafuchi A, Kageyama R, Shigemoto R, Shimamura K. 2014. Cadherin-based adhesions in the apical endfoot are required for active Notch signaling to control neurogenesis in vertebrates. Development. 141(8), 1671–1682.","mla":"Hatakeyama, Jun, et al. “Cadherin-Based Adhesions in the Apical Endfoot Are Required for Active Notch Signaling to Control Neurogenesis in Vertebrates.” <i>Development</i>, vol. 141, no. 8, Company of Biologists, 2014, pp. 1671–82, doi:<a href=\"https://doi.org/10.1242/dev.102988\">10.1242/dev.102988</a>.","ama":"Hatakeyama J, Wakamatsu Y, Nagafuchi A, Kageyama R, Shigemoto R, Shimamura K. Cadherin-based adhesions in the apical endfoot are required for active Notch signaling to control neurogenesis in vertebrates. <i>Development</i>. 2014;141(8):1671-1682. doi:<a href=\"https://doi.org/10.1242/dev.102988\">10.1242/dev.102988</a>","chicago":"Hatakeyama, Jun, Yoshio Wakamatsu, Akira Nagafuchi, Ryoichiro Kageyama, Ryuichi Shigemoto, and Kenji Shimamura. “Cadherin-Based Adhesions in the Apical Endfoot Are Required for Active Notch Signaling to Control Neurogenesis in Vertebrates.” <i>Development</i>. Company of Biologists, 2014. <a href=\"https://doi.org/10.1242/dev.102988\">https://doi.org/10.1242/dev.102988</a>.","ieee":"J. Hatakeyama, Y. Wakamatsu, A. Nagafuchi, R. Kageyama, R. Shigemoto, and K. Shimamura, “Cadherin-based adhesions in the apical endfoot are required for active Notch signaling to control neurogenesis in vertebrates,” <i>Development</i>, vol. 141, no. 8. Company of Biologists, pp. 1671–1682, 2014.","short":"J. Hatakeyama, Y. Wakamatsu, A. Nagafuchi, R. Kageyama, R. Shigemoto, K. Shimamura, Development 141 (2014) 1671–1682.","apa":"Hatakeyama, J., Wakamatsu, Y., Nagafuchi, A., Kageyama, R., Shigemoto, R., &#38; Shimamura, K. (2014). Cadherin-based adhesions in the apical endfoot are required for active Notch signaling to control neurogenesis in vertebrates. <i>Development</i>. Company of Biologists. <a href=\"https://doi.org/10.1242/dev.102988\">https://doi.org/10.1242/dev.102988</a>"},"scopus_import":1},{"date_created":"2018-12-11T11:54:48Z","day":"05","publisher":"Cell Press","_id":"1934","project":[{"name":"Hormonal cross-talk in plant organogenesis","_id":"253FCA6A-B435-11E9-9278-68D0E5697425","grant_number":"207362","call_identifier":"FP7"}],"oa_version":"None","page":"1031 - 1037","publication":"Current Biology","doi":"10.1016/j.cub.2014.04.002","ec_funded":1,"date_published":"2014-05-05T00:00:00Z","author":[{"id":"3F45B078-F248-11E8-B48F-1D18A9856A87","first_name":"Peter","last_name":"Marhavy","orcid":"0000-0001-5227-5741","full_name":"Marhavy, Peter"},{"first_name":"Jérôme","last_name":"Duclercq","full_name":"Duclercq, Jérôme"},{"first_name":"Benjamin","full_name":"Weller, Benjamin","last_name":"Weller"},{"last_name":"Feraru","full_name":"Feraru, Elena","first_name":"Elena"},{"full_name":"Bielach, Agnieszka","last_name":"Bielach","first_name":"Agnieszka"},{"last_name":"Offringa","full_name":"Offringa, Remko","first_name":"Remko"},{"first_name":"Jirí","id":"4159519E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8302-7596","full_name":"Friml, Jirí","last_name":"Friml"},{"first_name":"Claus","last_name":"Schwechheimer","full_name":"Schwechheimer, Claus"},{"full_name":"Murphy, Angus","last_name":"Murphy","first_name":"Angus"},{"first_name":"Eva","id":"38F4F166-F248-11E8-B48F-1D18A9856A87","last_name":"Benková","orcid":"0000-0002-8510-9739","full_name":"Benková, Eva"}],"year":"2014","month":"05","title":"Cytokinin controls polarity of PIN1-dependent Auxin transport during lateral root organogenesis","date_updated":"2021-01-12T06:54:10Z","department":[{"_id":"EvBe"},{"_id":"JiFr"}],"citation":{"mla":"Marhavý, Peter, et al. “Cytokinin Controls Polarity of PIN1-Dependent Auxin Transport during Lateral Root Organogenesis.” <i>Current Biology</i>, vol. 24, no. 9, Cell Press, 2014, pp. 1031–37, doi:<a href=\"https://doi.org/10.1016/j.cub.2014.04.002\">10.1016/j.cub.2014.04.002</a>.","ista":"Marhavý P, Duclercq J, Weller B, Feraru E, Bielach A, Offringa R, Friml J, Schwechheimer C, Murphy A, Benková E. 2014. Cytokinin controls polarity of PIN1-dependent Auxin transport during lateral root organogenesis. Current Biology. 24(9), 1031–1037.","ama":"Marhavý P, Duclercq J, Weller B, et al. Cytokinin controls polarity of PIN1-dependent Auxin transport during lateral root organogenesis. <i>Current Biology</i>. 2014;24(9):1031-1037. doi:<a href=\"https://doi.org/10.1016/j.cub.2014.04.002\">10.1016/j.cub.2014.04.002</a>","chicago":"Marhavý, Peter, Jérôme Duclercq, Benjamin Weller, Elena Feraru, Agnieszka Bielach, Remko Offringa, Jiří Friml, Claus Schwechheimer, Angus Murphy, and Eva Benková. “Cytokinin Controls Polarity of PIN1-Dependent Auxin Transport during Lateral Root Organogenesis.” <i>Current Biology</i>. Cell Press, 2014. <a href=\"https://doi.org/10.1016/j.cub.2014.04.002\">https://doi.org/10.1016/j.cub.2014.04.002</a>.","ieee":"P. Marhavý <i>et al.</i>, “Cytokinin controls polarity of PIN1-dependent Auxin transport during lateral root organogenesis,” <i>Current Biology</i>, vol. 24, no. 9. Cell Press, pp. 1031–1037, 2014.","apa":"Marhavý, P., Duclercq, J., Weller, B., Feraru, E., Bielach, A., Offringa, R., … Benková, E. (2014). Cytokinin controls polarity of PIN1-dependent Auxin transport during lateral root organogenesis. <i>Current Biology</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.cub.2014.04.002\">https://doi.org/10.1016/j.cub.2014.04.002</a>","short":"P. Marhavý, J. Duclercq, B. Weller, E. Feraru, A. Bielach, R. Offringa, J. Friml, C. Schwechheimer, A. Murphy, E. Benková, Current Biology 24 (2014) 1031–1037."},"type":"journal_article","scopus_import":1,"user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","issue":"9","intvolume":"        24","quality_controlled":"1","language":[{"iso":"eng"}],"status":"public","abstract":[{"text":"The plant hormones auxin and cytokinin mutually coordinate their activities to control various aspects of development [1-9], and their crosstalk occurs at multiple levels [10, 11]. Cytokinin-mediated modulation of auxin transport provides an efficient means to regulate auxin distribution in plant organs. Here, we demonstrate that cytokinin does not merely control the overall auxin flow capacity, but might also act as a polarizing cue and control the auxin stream directionality during plant organogenesis. Cytokinin enhances the PIN-FORMED1 (PIN1) auxin transporter depletion at specific polar domains, thus rearranging the cellular PIN polarities and directly regulating the auxin flow direction. This selective cytokinin sensitivity correlates with the PIN protein phosphorylation degree. PIN1 phosphomimicking mutations, as well as enhanced phosphorylation in plants with modulated activities of PIN-specific kinases and phosphatases, desensitize PIN1 to cytokinin. Our results reveal conceptually novel, cytokinin-driven polarization mechanism that operates in developmental processes involving rapid auxin stream redirection, such as lateral root organogenesis, in which a gradual PIN polarity switch defines the growth axis of the newly formed organ.","lang":"eng"}],"volume":24,"publication_status":"published","publist_id":"5160"},{"intvolume":"       331","oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","acknowledgement":"2014 by the authors. This paper may be reproduced, in its entirety, for non-commercial purposes.\r\n\r\nThe research leading to these results has received funding from the European Research\r\nCouncil under the European Union’s Seventh Framework Programme ERC Starting Grant CoMBoS (Grant Agreement No. 239694; A.G. and R.S.), the U.S. National Science Foundation (Grant PHY 0965859; E.H.L.), the Simons Foundation (Grant # 230207; E.H.L) and the NSERC (R.S.). The work is part of a project started in collaboration with Joel Lebowitz, whom we thank for many useful discussions and for his constant encouragement.","volume":331,"scopus_import":"1","article_processing_charge":"No","date_published":"2014-10-01T00:00:00Z","month":"10","date_updated":"2022-05-24T08:32:50Z","title":"Formation of stripes and slabs near the ferromagnetic transition","external_id":{"arxiv":["1304.6344"]},"date_created":"2018-12-11T11:54:48Z","_id":"1935","page":"333 - 350","publication":"Communications in Mathematical Physics","file_date_updated":"2022-05-24T08:30:40Z","quality_controlled":"1","has_accepted_license":"1","status":"public","language":[{"iso":"eng"}],"publist_id":"5159","abstract":[{"text":"We consider Ising models in d = 2 and d = 3 dimensions with nearest neighbor ferromagnetic and long-range antiferromagnetic interactions, the latter decaying as (distance)-p, p &gt; 2d, at large distances. If the strength J of the ferromagnetic interaction is larger than a critical value J c, then the ground state is homogeneous. It has been conjectured that when J is smaller than but close to J c, the ground state is periodic and striped, with stripes of constant width h = h(J), and h → ∞ as J → Jc -. (In d = 3 stripes mean slabs, not columns.) Here we rigorously prove that, if we normalize the energy in such a way that the energy of the homogeneous state is zero, then the ratio e 0(J)/e S(J) tends to 1 as J → Jc -, with e S(J) being the energy per site of the optimal periodic striped/slabbed state and e 0(J) the actual ground state energy per site of the system. Our proof comes with explicit bounds on the difference e 0(J)-e S(J) at small but positive J c-J, and also shows that in this parameter range the ground state is striped/slabbed in a certain sense: namely, if one looks at a randomly chosen window, of suitable size ℓ (very large compared to the optimal stripe size h(J)), one finds a striped/slabbed state with high probability.","lang":"eng"}],"publication_status":"published","article_type":"original","ddc":["510"],"citation":{"short":"A. Giuliani, É. Lieb, R. Seiringer, Communications in Mathematical Physics 331 (2014) 333–350.","apa":"Giuliani, A., Lieb, É., &#38; Seiringer, R. (2014). Formation of stripes and slabs near the ferromagnetic transition. <i>Communications in Mathematical Physics</i>. Springer. <a href=\"https://doi.org/10.1007/s00220-014-1923-2\">https://doi.org/10.1007/s00220-014-1923-2</a>","ieee":"A. Giuliani, É. Lieb, and R. Seiringer, “Formation of stripes and slabs near the ferromagnetic transition,” <i>Communications in Mathematical Physics</i>, vol. 331. Springer, pp. 333–350, 2014.","chicago":"Giuliani, Alessandro, Élliott Lieb, and Robert Seiringer. “Formation of Stripes and Slabs near the Ferromagnetic Transition.” <i>Communications in Mathematical Physics</i>. Springer, 2014. <a href=\"https://doi.org/10.1007/s00220-014-1923-2\">https://doi.org/10.1007/s00220-014-1923-2</a>.","ama":"Giuliani A, Lieb É, Seiringer R. Formation of stripes and slabs near the ferromagnetic transition. <i>Communications in Mathematical Physics</i>. 2014;331:333-350. doi:<a href=\"https://doi.org/10.1007/s00220-014-1923-2\">10.1007/s00220-014-1923-2</a>","mla":"Giuliani, Alessandro, et al. “Formation of Stripes and Slabs near the Ferromagnetic Transition.” <i>Communications in Mathematical Physics</i>, vol. 331, Springer, 2014, pp. 333–50, doi:<a href=\"https://doi.org/10.1007/s00220-014-1923-2\">10.1007/s00220-014-1923-2</a>.","ista":"Giuliani A, Lieb É, Seiringer R. 2014. Formation of stripes and slabs near the ferromagnetic transition. Communications in Mathematical Physics. 331, 333–350."},"type":"journal_article","file":[{"relation":"main_file","checksum":"c8423271cd1e1ba9e44c47af75efe7b6","file_size":334064,"content_type":"application/pdf","date_updated":"2022-05-24T08:30:40Z","file_name":"2014_CommMathPhysics_Giuliani.pdf","access_level":"open_access","success":1,"file_id":"11409","date_created":"2022-05-24T08:30:40Z","creator":"dernst"}],"year":"2014","author":[{"first_name":"Alessandro","full_name":"Giuliani, Alessandro","last_name":"Giuliani"},{"last_name":"Lieb","full_name":"Lieb, Élliott","first_name":"Élliott"},{"id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","first_name":"Robert","orcid":"0000-0002-6781-0521","full_name":"Seiringer, Robert","last_name":"Seiringer"}],"department":[{"_id":"RoSe"}],"publication_identifier":{"eissn":["1432-0916"],"issn":["0010-3616"]},"day":"01","publisher":"Springer","arxiv":1,"oa_version":"Published Version","doi":"10.1007/s00220-014-1923-2"},{"citation":{"short":"M. Arbilly, D. Weissman, M. Feldman, U. Grodzinski, Behavioral Ecology 25 (2014) 487–495.","apa":"Arbilly, M., Weissman, D., Feldman, M., &#38; Grodzinski, U. (2014). An arms race between producers and scroungers can drive the evolution of social cognition. <i>Behavioral Ecology</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/beheco/aru002\">https://doi.org/10.1093/beheco/aru002</a>","ieee":"M. Arbilly, D. Weissman, M. Feldman, and U. Grodzinski, “An arms race between producers and scroungers can drive the evolution of social cognition,” <i>Behavioral Ecology</i>, vol. 25, no. 3. Oxford University Press, pp. 487–495, 2014.","ama":"Arbilly M, Weissman D, Feldman M, Grodzinski U. An arms race between producers and scroungers can drive the evolution of social cognition. <i>Behavioral Ecology</i>. 2014;25(3):487-495. doi:<a href=\"https://doi.org/10.1093/beheco/aru002\">10.1093/beheco/aru002</a>","chicago":"Arbilly, Michal, Daniel Weissman, Marcus Feldman, and Uri Grodzinski. “An Arms Race between Producers and Scroungers Can Drive the Evolution of Social Cognition.” <i>Behavioral Ecology</i>. Oxford University Press, 2014. <a href=\"https://doi.org/10.1093/beheco/aru002\">https://doi.org/10.1093/beheco/aru002</a>.","mla":"Arbilly, Michal, et al. “An Arms Race between Producers and Scroungers Can Drive the Evolution of Social Cognition.” <i>Behavioral Ecology</i>, vol. 25, no. 3, Oxford University Press, 2014, pp. 487–95, doi:<a href=\"https://doi.org/10.1093/beheco/aru002\">10.1093/beheco/aru002</a>.","ista":"Arbilly M, Weissman D, Feldman M, Grodzinski U. 2014. An arms race between producers and scroungers can drive the evolution of social cognition. Behavioral Ecology. 25(3), 487–495."},"type":"journal_article","quality_controlled":"1","publist_id":"5157","abstract":[{"text":"The social intelligence hypothesis states that the need to cope with complexities of social life has driven the evolution of advanced cognitive abilities. It is usually invoked in the context of challenges arising from complex intragroup structures, hierarchies, and alliances. However, a fundamental aspect of group living remains largely unexplored as a driving force in cognitive evolution: the competition between individuals searching for resources (producers) and conspecifics that parasitize their findings (scroungers). In populations of social foragers, abilities that enable scroungers to steal by outsmarting producers, and those allowing producers to prevent theft by outsmarting scroungers, are likely to be beneficial and may fuel a cognitive arms race. Using analytical theory and agent-based simulations, we present a general model for such a race that is driven by the producer-scrounger game and show that the race's plausibility is dramatically affected by the nature of the evolving abilities. If scrounging and scrounging avoidance rely on separate, strategy-specific cognitive abilities, arms races are short-lived and have a limited effect on cognition. However, general cognitive abilities that facilitate both scrounging and scrounging avoidance undergo stable, long-lasting arms races. Thus, ubiquitous foraging interactions may lead to the evolution of general cognitive abilities in social animals, without the requirement of complex intragroup structures.","lang":"eng"}],"publication_status":"published","status":"public","language":[{"iso":"eng"}],"publisher":"Oxford University Press","day":"13","doi":"10.1093/beheco/aru002","oa_version":"Submitted Version","year":"2014","author":[{"last_name":"Arbilly","full_name":"Arbilly, Michal","first_name":"Michal"},{"last_name":"Weissman","full_name":"Weissman, Daniel","first_name":"Daniel","id":"2D0CE020-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Feldman","full_name":"Feldman, Marcus","first_name":"Marcus"},{"full_name":"Grodzinski, Uri","last_name":"Grodzinski","first_name":"Uri"}],"department":[{"_id":"NiBa"}],"scopus_import":1,"intvolume":"        25","oa":1,"user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","issue":"3","main_file_link":[{"open_access":"1","url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014306/"}],"volume":25,"project":[{"name":"Limits to selection in biology and in evolutionary computation","_id":"25B07788-B435-11E9-9278-68D0E5697425","grant_number":"250152","call_identifier":"FP7"}],"_id":"1936","date_created":"2018-12-11T11:54:48Z","publication":"Behavioral Ecology","page":"487 - 495","date_published":"2014-02-13T00:00:00Z","ec_funded":1,"title":"An arms race between producers and scroungers can drive the evolution of social cognition","date_updated":"2021-01-12T06:54:11Z","month":"02"},{"quality_controlled":"1","publication_status":"published","abstract":[{"text":"We prove the edge universality of the beta ensembles for any β ≥ 1, provided that the limiting spectrum is supported on a single interval, and the external potential is C4 and regular. We also prove that the edge universality holds for generalized Wigner matrices for all symmetry classes. Moreover, our results allow us to extend bulk universality for beta ensembles from analytic potentials to potentials in class C4.","lang":"eng"}],"publist_id":"5158","language":[{"iso":"eng"}],"status":"public","citation":{"ama":"Bourgade P, Erdös L, Yau H. Edge universality of beta ensembles. <i>Communications in Mathematical Physics</i>. 2014;332(1):261-353. doi:<a href=\"https://doi.org/10.1007/s00220-014-2120-z\">10.1007/s00220-014-2120-z</a>","chicago":"Bourgade, Paul, László Erdös, and Horngtzer Yau. “Edge Universality of Beta Ensembles.” <i>Communications in Mathematical Physics</i>. Springer, 2014. <a href=\"https://doi.org/10.1007/s00220-014-2120-z\">https://doi.org/10.1007/s00220-014-2120-z</a>.","ista":"Bourgade P, Erdös L, Yau H. 2014. Edge universality of beta ensembles. Communications in Mathematical Physics. 332(1), 261–353.","mla":"Bourgade, Paul, et al. “Edge Universality of Beta Ensembles.” <i>Communications in Mathematical Physics</i>, vol. 332, no. 1, Springer, 2014, pp. 261–353, doi:<a href=\"https://doi.org/10.1007/s00220-014-2120-z\">10.1007/s00220-014-2120-z</a>.","short":"P. Bourgade, L. Erdös, H. Yau, Communications in Mathematical Physics 332 (2014) 261–353.","apa":"Bourgade, P., Erdös, L., &#38; Yau, H. (2014). Edge universality of beta ensembles. <i>Communications in Mathematical Physics</i>. Springer. <a href=\"https://doi.org/10.1007/s00220-014-2120-z\">https://doi.org/10.1007/s00220-014-2120-z</a>","ieee":"P. Bourgade, L. Erdös, and H. Yau, “Edge universality of beta ensembles,” <i>Communications in Mathematical Physics</i>, vol. 332, no. 1. Springer, pp. 261–353, 2014."},"type":"journal_article","author":[{"first_name":"Paul","last_name":"Bourgade","full_name":"Bourgade, Paul"},{"full_name":"Erdös, László","orcid":"0000-0001-5366-9603","last_name":"Erdös","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","first_name":"László"},{"full_name":"Yau, Horngtzer","last_name":"Yau","first_name":"Horngtzer"}],"year":"2014","department":[{"_id":"LaEr"}],"publisher":"Springer","day":"01","doi":"10.1007/s00220-014-2120-z","oa_version":"Submitted Version","issue":"1","user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","intvolume":"       332","oa":1,"volume":332,"main_file_link":[{"open_access":"1","url":"http://arxiv.org/abs/1306.5728"}],"scopus_import":1,"date_published":"2014-11-01T00:00:00Z","date_updated":"2021-01-12T06:54:12Z","title":"Edge universality of beta ensembles","month":"11","_id":"1937","project":[{"name":"Glutamaterge synaptische Übertragung und Plastizität in hippocampalen Mikroschaltkreisen","grant_number":"SFB-TR3-TP10B","_id":"25BDE9A4-B435-11E9-9278-68D0E5697425"}],"date_created":"2018-12-11T11:54:48Z","publication":"Communications in Mathematical Physics","page":"261 - 353"},{"quality_controlled":0,"issue":"4","intvolume":"        46","abstract":[{"text":"NADH-ubiquinone oxidoreductase (complex I) is the first and largest enzyme in the respiratory chain of mitochondria and many bacteria. It couples the transfer of two electrons between NADH and ubiquinone to the translocation of four protons across the membrane. Complex I is an L-shaped assembly formed by the hydrophilic (peripheral) arm, containing all the redox centres performing electron transfer and the membrane arm, containing proton-translocating machinery. Mitochondrial complex I consists of 44 subunits of about 1 MDa in total, whilst the prokaryotic enzyme is simpler and generally consists of 14 conserved “core” subunits. Recently we have determined the first atomic structure of the entire complex I, using the enzyme from Thermus thermophilus (536 kDa, 16 subunits, 9 Fe-S clusters, 64 TM helices). Structure suggests a unique coupling mechanism, with redox energy of electron transfer driving proton translocation via long-range (up to ~200 Å) conformational changes. It resembles a steam engine, with coupling elements (akin to coupling rods) linking parts of this molecular machine.","lang":"eng"}],"publication_status":"published","volume":46,"publist_id":"5104","status":"public","type":"journal_article","citation":{"chicago":"Sazanov, Leonid A. “The Mechanism of Coupling between Electron Transfer and Proton Translocation in Respiratory Complex I.” <i>Journal of Bioenergetics and Biomembranes</i>. Springer, 2014. <a href=\"https://doi.org/10.1007/s10863-014-9554-z\">https://doi.org/10.1007/s10863-014-9554-z</a>.","ama":"Sazanov LA. The mechanism of coupling between electron transfer and proton translocation in respiratory complex I. <i>Journal of Bioenergetics and Biomembranes</i>. 2014;46(4):247-253. doi:<a href=\"https://doi.org/10.1007/s10863-014-9554-z\">10.1007/s10863-014-9554-z</a>","mla":"Sazanov, Leonid A. “The Mechanism of Coupling between Electron Transfer and Proton Translocation in Respiratory Complex I.” <i>Journal of Bioenergetics and Biomembranes</i>, vol. 46, no. 4, Springer, 2014, pp. 247–53, doi:<a href=\"https://doi.org/10.1007/s10863-014-9554-z\">10.1007/s10863-014-9554-z</a>.","ista":"Sazanov LA. 2014. The mechanism of coupling between electron transfer and proton translocation in respiratory complex I. Journal of Bioenergetics and Biomembranes. 46(4), 247–253.","short":"L.A. Sazanov, Journal of Bioenergetics and Biomembranes 46 (2014) 247–253.","apa":"Sazanov, L. A. (2014). The mechanism of coupling between electron transfer and proton translocation in respiratory complex I. <i>Journal of Bioenergetics and Biomembranes</i>. Springer. <a href=\"https://doi.org/10.1007/s10863-014-9554-z\">https://doi.org/10.1007/s10863-014-9554-z</a>","ieee":"L. A. Sazanov, “The mechanism of coupling between electron transfer and proton translocation in respiratory complex I,” <i>Journal of Bioenergetics and Biomembranes</i>, vol. 46, no. 4. Springer, pp. 247–253, 2014."},"extern":1,"author":[{"last_name":"Sazanov","full_name":"Leonid Sazanov","orcid":"0000-0002-0977-7989","first_name":"Leonid A","id":"338D39FE-F248-11E8-B48F-1D18A9856A87"}],"date_published":"2014-08-01T00:00:00Z","year":"2014","date_updated":"2021-01-12T06:54:28Z","title":"The mechanism of coupling between electron transfer and proton translocation in respiratory complex I","month":"08","publisher":"Springer","_id":"1979","date_created":"2018-12-11T11:55:01Z","day":"01","publication":"Journal of Bioenergetics and Biomembranes","doi":"10.1007/s10863-014-9554-z","page":"247 - 253"},{"extern":1,"citation":{"ista":"Heikal A, Nakatani Y, Dunn E, Weimar M, Day C, Baker E, Lott S, Sazanov LA, Cook G. 2014. Structure of the bacterial type II NADH dehydrogenase: a monotopic membrane protein with an essential role in energy generation. Molecular Microbiology. 91(5), 950–964.","mla":"Heikal, Adam, et al. “Structure of the Bacterial Type II NADH Dehydrogenase: A Monotopic Membrane Protein with an Essential Role in Energy Generation.” <i>Molecular Microbiology</i>, vol. 91, no. 5, Wiley-Blackwell, 2014, pp. 950–64, doi:<a href=\"https://doi.org/10.1111/mmi.12507\">10.1111/mmi.12507</a>.","chicago":"Heikal, Adam, Yoshio Nakatani, Elyse Dunn, Marion Weimar, Catherine Day, Edward Baker, Shaun Lott, Leonid A Sazanov, and Gregory Cook. “Structure of the Bacterial Type II NADH Dehydrogenase: A Monotopic Membrane Protein with an Essential Role in Energy Generation.” <i>Molecular Microbiology</i>. Wiley-Blackwell, 2014. <a href=\"https://doi.org/10.1111/mmi.12507\">https://doi.org/10.1111/mmi.12507</a>.","ama":"Heikal A, Nakatani Y, Dunn E, et al. Structure of the bacterial type II NADH dehydrogenase: a monotopic membrane protein with an essential role in energy generation. <i>Molecular Microbiology</i>. 2014;91(5):950-964. doi:<a href=\"https://doi.org/10.1111/mmi.12507\">10.1111/mmi.12507</a>","ieee":"A. Heikal <i>et al.</i>, “Structure of the bacterial type II NADH dehydrogenase: a monotopic membrane protein with an essential role in energy generation,” <i>Molecular Microbiology</i>, vol. 91, no. 5. Wiley-Blackwell, pp. 950–964, 2014.","short":"A. Heikal, Y. Nakatani, E. Dunn, M. Weimar, C. Day, E. Baker, S. Lott, L.A. Sazanov, G. Cook, Molecular Microbiology 91 (2014) 950–964.","apa":"Heikal, A., Nakatani, Y., Dunn, E., Weimar, M., Day, C., Baker, E., … Cook, G. (2014). Structure of the bacterial type II NADH dehydrogenase: a monotopic membrane protein with an essential role in energy generation. <i>Molecular Microbiology</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1111/mmi.12507\">https://doi.org/10.1111/mmi.12507</a>"},"type":"journal_article","status":"public","publist_id":"5103","publication_status":"published","volume":91,"abstract":[{"lang":"eng","text":"Non-proton pumping type II NADH dehydrogenase (NDH-2) plays a central role in the respiratory metabolism of bacteria, and in the mitochondria of fungi, plants and protists. The lack of NDH-2 in mammalian mitochondria and its essentiality in important bacterial pathogens suggests these enzymes may represent a potential new drug target to combat microbial pathogens. Here, we report the first crystal structure of a bacterial NDH-2 enzyme at 2.5Å resolution from Caldalkalibacillus thermarum. The NDH-2 structure reveals a homodimeric organization that has a unique dimer interface. NDH-2 is localized to the cytoplasmic membrane by two separated C-terminal membrane-anchoring regions that are essential for membrane localization and FAD binding, but not NDH-2 dimerization. Comparison of bacterial NDH-2 with the yeast NADH dehydrogenase (Ndi1) structure revealed non-overlapping binding sites for quinone and NADH in the bacterial enzyme. The bacterial NDH-2 structure establishes a framework for the structure-based design of small-molecule inhibitors."}],"intvolume":"        91","acknowledgement":"Funded by      Health Research Council of New Zealand     Royal Society of New Zealand     University of Otago     New Zealand Synchrotron Group","issue":"5","quality_controlled":0,"page":"950 - 964","publication":"Molecular Microbiology","doi":"10.1111/mmi.12507","day":"01","date_created":"2018-12-11T11:55:01Z","publisher":"Wiley-Blackwell","_id":"1980","month":"03","date_updated":"2021-01-12T06:54:29Z","title":"Structure of the bacterial type II NADH dehydrogenase: a monotopic membrane protein with an essential role in energy generation","year":"2014","date_published":"2014-03-01T00:00:00Z","author":[{"last_name":"Heikal","full_name":"Heikal, Adam ","first_name":"Adam"},{"last_name":"Nakatani","full_name":"Nakatani, Yoshio","first_name":"Yoshio"},{"last_name":"Dunn","full_name":"Dunn, Elyse A","first_name":"Elyse"},{"first_name":"Marion","full_name":"Weimar, Marion R","last_name":"Weimar"},{"last_name":"Day","full_name":"Day, Catherine","first_name":"Catherine"},{"first_name":"Edward","last_name":"Baker","full_name":"Baker, Edward N"},{"first_name":"Shaun","full_name":"Lott, Shaun J","last_name":"Lott"},{"first_name":"Leonid A","id":"338D39FE-F248-11E8-B48F-1D18A9856A87","full_name":"Leonid Sazanov","orcid":"0000-0002-0977-7989","last_name":"Sazanov"},{"first_name":"Gregory","last_name":"Cook","full_name":"Cook, Gregory"}]}]