[{"publication_status":"published","month":"07","abstract":[{"lang":"eng","text":"For suitable pairs of diagonal quadratic forms in eight variables we use the circle method to investigate the density of simultaneous integer solutions and relate this to the problem of estimating linear correlations among sums of two squares."}],"issue":"4","date_published":"2015-07-10T00:00:00Z","publisher":"Walter de Gruyter GmbH","title":"Pairs of diagonal quadratic forms and linear correlations among sums of two squares","volume":27,"extern":1,"quality_controlled":0,"date_updated":"2021-01-12T06:58:18Z","citation":{"apa":"Browning, T. D., & Munshi, R. (2015). Pairs of diagonal quadratic forms and linear correlations among sums of two squares. Forum Mathematicum. Walter de Gruyter GmbH. https://doi.org/10.1515/forum-2013-6024","ama":"Browning TD, Munshi R. Pairs of diagonal quadratic forms and linear correlations among sums of two squares. Forum Mathematicum. 2015;27(4):2025-2050. doi:10.1515/forum-2013-6024","ista":"Browning TD, Munshi R. 2015. Pairs of diagonal quadratic forms and linear correlations among sums of two squares. Forum Mathematicum. 27(4), 2025–2050.","chicago":"Browning, Timothy D, and Ritabrata Munshi. “Pairs of Diagonal Quadratic Forms and Linear Correlations among Sums of Two Squares.” Forum Mathematicum. Walter de Gruyter GmbH, 2015. https://doi.org/10.1515/forum-2013-6024.","ieee":"T. D. Browning and R. Munshi, “Pairs of diagonal quadratic forms and linear correlations among sums of two squares,” Forum Mathematicum, vol. 27, no. 4. Walter de Gruyter GmbH, pp. 2025–2050, 2015.","short":"T.D. Browning, R. Munshi, Forum Mathematicum 27 (2015) 2025–2050.","mla":"Browning, Timothy D., and Ritabrata Munshi. “Pairs of Diagonal Quadratic Forms and Linear Correlations among Sums of Two Squares.” Forum Mathematicum, vol. 27, no. 4, Walter de Gruyter GmbH, 2015, pp. 2025–50, doi:10.1515/forum-2013-6024."},"author":[{"full_name":"Timothy Browning","id":"35827D50-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8314-0177","first_name":"Timothy D","last_name":"Browning"},{"last_name":"Munshi","first_name":"Ritabrata","full_name":"Munshi, Ritabrata"}],"publist_id":"7645","intvolume":" 27","publication":"Forum Mathematicum","oa":1,"date_created":"2018-12-11T11:45:28Z","type":"journal_article","_id":"257","acknowledgement":"While working on this paper the first author was supported by ERC grant 306457 and the second author was supported by SwarnaJayanti Fellowship 2011–12, DST, Government of India.","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1302.2434"}],"doi":"10.1515/forum-2013-6024","status":"public","page":"2025 - 2050","day":"10","year":"2015"},{"publication":"Arithmetic and Geometry","publist_id":"7644","type":"book_chapter","_id":"258","date_created":"2018-12-11T11:45:28Z","page":"89 - 113","doi":"10.1017/CBO9781316106877.009","year":"2015","status":"public","day":"01","abstract":[{"lang":"eng","text":"Given a number field k and a projective algebraic variety X defined over k, the question of whether X contains a k-rational point is both very natural and very difficult. In the event that the set X(k) of k-rational points is not empty, one can also ask how the points of X(k) are distributed. Are they dense in X under the Zariski topology? Are they dense in the set."}],"publication_status":"published","month":"08","title":"A survey of applications of the circle method to rational points","publisher":"Cambridge University Press","date_published":"2015-08-01T00:00:00Z","language":[{"iso":"eng"}],"citation":{"ama":"Browning TD. A survey of applications of the circle method to rational points. In: Arithmetic and Geometry. Cambridge University Press; 2015:89-113. doi:10.1017/CBO9781316106877.009","ista":"Browning TD. 2015.A survey of applications of the circle method to rational points. In: Arithmetic and Geometry. , 89–113.","chicago":"Browning, Timothy D. “A Survey of Applications of the Circle Method to Rational Points.” In Arithmetic and Geometry, 89–113. Cambridge University Press, 2015. https://doi.org/10.1017/CBO9781316106877.009.","apa":"Browning, T. D. (2015). A survey of applications of the circle method to rational points. In Arithmetic and Geometry (pp. 89–113). Cambridge University Press. https://doi.org/10.1017/CBO9781316106877.009","ieee":"T. D. Browning, “A survey of applications of the circle method to rational points,” in Arithmetic and Geometry, Cambridge University Press, 2015, pp. 89–113.","mla":"Browning, Timothy D. “A Survey of Applications of the Circle Method to Rational Points.” Arithmetic and Geometry, Cambridge University Press, 2015, pp. 89–113, doi:10.1017/CBO9781316106877.009.","short":"T.D. Browning, in:, Arithmetic and Geometry, Cambridge University Press, 2015, pp. 89–113."},"oa_version":"None","date_updated":"2021-01-12T06:58:22Z","quality_controlled":"1","extern":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"full_name":"Browning, Timothy D","id":"35827D50-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8314-0177","first_name":"Timothy D","last_name":"Browning"}]},{"year":"2015","day":"11","status":"public","doi":"10.1007/s00039-015-0328-5","page":"671 - 732","acknowledgement":"EP/J018260/1\tEngineering and Physical Sciences Research Council EPSRC","_id":"259","type":"journal_article","date_created":"2018-12-11T11:45:29Z","publication":"Geometric and Functional Analysis","publist_id":"7643","intvolume":" 25","author":[{"id":"35827D50-F248-11E8-B48F-1D18A9856A87","full_name":"Timothy Browning","first_name":"Timothy D","last_name":"Browning","orcid":"0000-0002-8314-0177"},{"full_name":"Vishe, Pankaj","last_name":"Vishe","first_name":"Pankaj"}],"citation":{"mla":"Browning, Timothy D., and Pankaj Vishe. “Rational Points on Cubic Hypersurfaces over F_q(T) .” Geometric and Functional Analysis, vol. 25, no. 3, Birkhäuser, 2015, pp. 671–732, doi:10.1007/s00039-015-0328-5.","short":"T.D. Browning, P. Vishe, Geometric and Functional Analysis 25 (2015) 671–732.","apa":"Browning, T. D., & Vishe, P. (2015). Rational points on cubic hypersurfaces over F_q(t) . Geometric and Functional Analysis. Birkhäuser. https://doi.org/10.1007/s00039-015-0328-5","ista":"Browning TD, Vishe P. 2015. Rational points on cubic hypersurfaces over F_q(t) . Geometric and Functional Analysis. 25(3), 671–732.","ama":"Browning TD, Vishe P. Rational points on cubic hypersurfaces over F_q(t) . Geometric and Functional Analysis. 2015;25(3):671-732. doi:10.1007/s00039-015-0328-5","chicago":"Browning, Timothy D, and Pankaj Vishe. “Rational Points on Cubic Hypersurfaces over F_q(T) .” Geometric and Functional Analysis. Birkhäuser, 2015. https://doi.org/10.1007/s00039-015-0328-5.","ieee":"T. D. Browning and P. Vishe, “Rational points on cubic hypersurfaces over F_q(t) ,” Geometric and Functional Analysis, vol. 25, no. 3. Birkhäuser, pp. 671–732, 2015."},"extern":1,"quality_controlled":0,"date_updated":"2021-01-12T06:58:25Z","volume":25,"title":"Rational points on cubic hypersurfaces over F_q(t) ","date_published":"2015-06-11T00:00:00Z","publisher":"Birkhäuser","issue":"3","month":"06","publication_status":"published","abstract":[{"lang":"eng","text":"The Hasse principle and weak approximation is established for non-singular cubic hypersurfaces X over the function field "}]},{"external_id":{"arxiv":["1402.4489"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","extern":"1","date_updated":"2024-03-05T12:09:22Z","citation":{"short":"T.D. Browning, S. Prendiville, Journal Fur Die Reine Und Angewandte Mathematik 2017 (n.d.) 203–234.","mla":"Browning, Timothy D., and Sean Prendiville. “Improvements in Birch’s Theorem on Forms in Many Variables.” Journal Fur Die Reine Und Angewandte Mathematik, vol. 2017, no. 731, Walter de Gruyter, pp. 203–34, doi:10.1515/crelle-2014-0122.","ieee":"T. D. Browning and S. Prendiville, “Improvements in Birch’s theorem on forms in many variables,” Journal fur die Reine und Angewandte Mathematik, vol. 2017, no. 731. Walter de Gruyter, pp. 203–234.","ista":"Browning TD, Prendiville S. Improvements in Birch’s theorem on forms in many variables. Journal fur die Reine und Angewandte Mathematik. 2017(731), 203–234.","chicago":"Browning, Timothy D, and Sean Prendiville. “Improvements in Birch’s Theorem on Forms in Many Variables.” Journal Fur Die Reine Und Angewandte Mathematik. Walter de Gruyter, n.d. https://doi.org/10.1515/crelle-2014-0122.","ama":"Browning TD, Prendiville S. Improvements in Birch’s theorem on forms in many variables. Journal fur die Reine und Angewandte Mathematik. 2017(731):203-234. doi:10.1515/crelle-2014-0122","apa":"Browning, T. D., & Prendiville, S. (n.d.). Improvements in Birch’s theorem on forms in many variables. Journal Fur Die Reine Und Angewandte Mathematik. Walter de Gruyter. https://doi.org/10.1515/crelle-2014-0122"},"publisher":"Walter de Gruyter","date_published":"2015-02-20T00:00:00Z","title":"Improvements in Birch's theorem on forms in many variables","publication_status":"submitted","abstract":[{"text":"We show that a non-singular integral form of degree d is soluble non-trivially over the integers if and only if it is soluble non-trivially over the reals and the p-adic numbers, provided that the form has at least (d-\\sqrt{d}/2)2^d variables. This improves on a longstanding result of Birch.","lang":"eng"}],"acknowledgement":"While working on this paper the authors were supported by the Leverhulme Trust and ERC grant 306457.","year":"2015","day":"20","doi":"10.1515/crelle-2014-0122","page":"203 - 234","oa":1,"publist_id":"7631","arxiv":1,"intvolume":" 2017","publication":"Journal fur die Reine und Angewandte Mathematik","related_material":{"record":[{"id":"256","relation":"later_version","status":"public"}]},"author":[{"first_name":"Timothy D","last_name":"Browning","orcid":"0000-0002-8314-0177","id":"35827D50-F248-11E8-B48F-1D18A9856A87","full_name":"Browning, Timothy D"},{"last_name":"Prendiville","first_name":"Sean","full_name":"Prendiville, Sean"}],"quality_controlled":"1","oa_version":"Preprint","language":[{"iso":"eng"}],"volume":2017,"article_processing_charge":"No","month":"02","issue":"731","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1402.4489"}],"status":"public","publication_identifier":{"issn":["0075-4102"]},"date_created":"2018-12-11T11:45:32Z","article_type":"original","_id":"271","type":"journal_article"},{"publisher":"ACS","language":[{"iso":"eng"}],"date_published":"2015-10-16T00:00:00Z","volume":27,"title":"Efficient and inexpensive sodium magnesium hybrid battery","article_processing_charge":"No","publication_status":"published","month":"10","abstract":[{"text":"We present a hybrid intercalation battery based on a sodium/magnesium (Na/Mg) dual salt electrolyte, metallic magnesium anode, and a cathode based on FeS2 nanocrystals (NCs). Compared to lithium or sodium, metallic magnesium anode is safer due to dendrite-free electroplating and offers extremely high volumetric (3833 mAh cm-3) and gravimetric capacities (2205 mAh g-1). Na-ion cathodes, FeS2 NCs in the present study, may serve as attractive alternatives to Mg-ion cathodes due to the higher voltage of operation and fast, highly reversible insertion of Na-ions. In this proof-of-concept study, electrochemical cycling of the Na/Mg hybrid battery was characterized by high rate capability, high Coulombic efficiency of 99.8%, and high energy density. In particular, with an average discharge voltage of ∼1.1 V and a cathodic capacity of 189 mAh g-1 at a current of 200 mA g-1, the presented Mg/FeS2 hybrid battery delivers energy densities of up to 210 Wh kg-1, comparable to commercial Li-ion batteries and approximately twice as high as state-of-the-art Mg-ion batteries based on Mo6S8 cathodes. Further significant gains in the energy density are expected from the development of Na/Mg electrolytes with a broader electrochemical stability window. Fully based on Earth-abundant elements, hybrid Na-Mg batteries are highly promising for large-scale stationary energy storage. ","lang":"eng"}],"issue":"21","author":[{"first_name":"Marc","last_name":"Walter","full_name":"Walter, Marc"},{"first_name":"Kostiantyn","last_name":"Kravchyk","full_name":"Kravchyk, Kostiantyn"},{"first_name":"Maria","last_name":"Ibáñez","orcid":"0000-0001-5013-2843","id":"43C61214-F248-11E8-B48F-1D18A9856A87","full_name":"Ibáñez, Maria"},{"first_name":"Maksym","last_name":"Kovalenko","full_name":"Kovalenko, Maksym"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","extern":"1","quality_controlled":"1","date_updated":"2021-01-12T07:42:42Z","citation":{"short":"M. Walter, K. Kravchyk, M. Ibáñez, M. Kovalenko, Chemistry of Materials 27 (2015) 7452–7458.","mla":"Walter, Marc, et al. “Efficient and Inexpensive Sodium Magnesium Hybrid Battery.” Chemistry of Materials, vol. 27, no. 21, ACS, 2015, pp. 7452–58, doi:10.1021/acs.chemmater.5b03531.","ieee":"M. Walter, K. Kravchyk, M. Ibáñez, and M. Kovalenko, “Efficient and inexpensive sodium magnesium hybrid battery,” Chemistry of Materials, vol. 27, no. 21. ACS, pp. 7452–7458, 2015.","apa":"Walter, M., Kravchyk, K., Ibáñez, M., & Kovalenko, M. (2015). Efficient and inexpensive sodium magnesium hybrid battery. Chemistry of Materials. ACS. https://doi.org/10.1021/acs.chemmater.5b03531","ama":"Walter M, Kravchyk K, Ibáñez M, Kovalenko M. Efficient and inexpensive sodium magnesium hybrid battery. Chemistry of Materials. 2015;27(21):7452-7458. doi:10.1021/acs.chemmater.5b03531","ista":"Walter M, Kravchyk K, Ibáñez M, Kovalenko M. 2015. Efficient and inexpensive sodium magnesium hybrid battery. Chemistry of Materials. 27(21), 7452–7458.","chicago":"Walter, Marc, Kostiantyn Kravchyk, Maria Ibáñez, and Maksym Kovalenko. “Efficient and Inexpensive Sodium Magnesium Hybrid Battery.” Chemistry of Materials. ACS, 2015. https://doi.org/10.1021/acs.chemmater.5b03531."},"oa_version":"None","publist_id":"7507","intvolume":" 27","publication":"Chemistry of Materials","year":"2015","status":"public","doi":"10.1021/acs.chemmater.5b03531","day":"16","page":"7452 - 7458","date_created":"2018-12-11T11:45:52Z","article_type":"original","_id":"333","type":"journal_article"},{"author":[{"last_name":"Yu","first_name":"Xuelian","full_name":"Yu, Xuelian"},{"full_name":"Liu, Jingjing","first_name":"Jingjing","last_name":"Liu"},{"last_name":"Genç","first_name":"Aziz","full_name":"Genç, Aziz"},{"first_name":"Maria","last_name":"Ibáñez","orcid":"0000-0001-5013-2843","id":"43C61214-F248-11E8-B48F-1D18A9856A87","full_name":"Ibáñez, Maria"},{"full_name":"Luo, Zhishan","last_name":"Luo","first_name":"Zhishan"},{"first_name":"Alexey","last_name":"Shavel","full_name":"Shavel, Alexey"},{"last_name":"Arbiol","first_name":"Jordi","full_name":"Arbiol, Jordi"},{"first_name":"Guangjin","last_name":"Zhang","full_name":"Zhang, Guangjin"},{"last_name":"Zhang","first_name":"Yihe","full_name":"Zhang, Yihe"},{"last_name":"Cabot","first_name":"Andreu","full_name":"Cabot, Andreu"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2021-01-12T07:42:46Z","extern":"1","quality_controlled":"1","oa_version":"None","citation":{"ieee":"X. Yu et al., “Cu2ZnSnS4–Ag2S Nanoscale p–n heterostructures as sensitizers for photoelectrochemical water splitting,” Langmuir, vol. 31, no. 38. American Chemical Society, pp. 10555–10561, 2015.","ama":"Yu X, Liu J, Genç A, et al. Cu2ZnSnS4–Ag2S Nanoscale p–n heterostructures as sensitizers for photoelectrochemical water splitting. Langmuir. 2015;31(38):10555-10561. doi:10.1021/acs.langmuir.5b02490","ista":"Yu X, Liu J, Genç A, Ibáñez M, Luo Z, Shavel A, Arbiol J, Zhang G, Zhang Y, Cabot A. 2015. Cu2ZnSnS4–Ag2S Nanoscale p–n heterostructures as sensitizers for photoelectrochemical water splitting. Langmuir. 31(38), 10555–10561.","chicago":"Yu, Xuelian, Jingjing Liu, Aziz Genç, Maria Ibáñez, Zhishan Luo, Alexey Shavel, Jordi Arbiol, Guangjin Zhang, Yihe Zhang, and Andreu Cabot. “Cu2ZnSnS4–Ag2S Nanoscale p–n Heterostructures as Sensitizers for Photoelectrochemical Water Splitting.” Langmuir. American Chemical Society, 2015. https://doi.org/10.1021/acs.langmuir.5b02490.","apa":"Yu, X., Liu, J., Genç, A., Ibáñez, M., Luo, Z., Shavel, A., … Cabot, A. (2015). Cu2ZnSnS4–Ag2S Nanoscale p–n heterostructures as sensitizers for photoelectrochemical water splitting. Langmuir. American Chemical Society. https://doi.org/10.1021/acs.langmuir.5b02490","mla":"Yu, Xuelian, et al. “Cu2ZnSnS4–Ag2S Nanoscale p–n Heterostructures as Sensitizers for Photoelectrochemical Water Splitting.” Langmuir, vol. 31, no. 38, American Chemical Society, 2015, pp. 10555–61, doi:10.1021/acs.langmuir.5b02490.","short":"X. Yu, J. Liu, A. Genç, M. Ibáñez, Z. Luo, A. Shavel, J. Arbiol, G. Zhang, Y. Zhang, A. Cabot, Langmuir 31 (2015) 10555–10561."},"publisher":"American Chemical Society","date_published":"2015-09-07T00:00:00Z","language":[{"iso":"eng"}],"article_processing_charge":"No","title":"Cu2ZnSnS4–Ag2S Nanoscale p–n heterostructures as sensitizers for photoelectrochemical water splitting","volume":31,"abstract":[{"lang":"eng","text":"A cation exchange-based route was used to produce Cu2ZnSnS4 (CZTS)-Ag2S nanoparticles with controlled composition. We report a detailed study of the formation of such CZTS-Ag2S nanoheterostructures and of their photocatalytic properties. When compared to pure CZTS, the use of nanoscale p-n heterostructures as light absorbers for photocatalytic water splitting provides superior photocurrents. We associate this experimental fact to a higher separation efficiency of the photogenerated electron-hole pairs. We believe this and other type-II nanoheterostructures will open the door to the use of CZTS, with excellent light absorption properties and made of abundant and environmental friendly elements, to the field of photocatalysis."}],"month":"09","publication_status":"published","issue":"38","acknowledgement":"This work was supported by the European Regional Development Funds, the Framework 7 program under project SCALENANO (FP7-NMP-ENERGY-2011-284486), the Spanish MINECO under Contract ENE2013-46624-C4-3-R and Fundamental Research Funds for the Central Universities (2652015086). Authors acknowledge the funding from Generalitat de Catalunya 2014 SGR 1638.","doi":"10.1021/acs.langmuir.5b02490","year":"2015","day":"07","status":"public","page":"10555 - 10561","date_created":"2018-12-11T11:45:52Z","type":"journal_article","_id":"334","article_type":"original","intvolume":" 31","publist_id":"7508","publication":"Langmuir"},{"author":[{"orcid":"0000-0001-8223-8896","first_name":"Hryhoriy","last_name":"Polshyn","full_name":"Polshyn, Hryhoriy","id":"edfc7cb1-526e-11ec-b05a-e6ecc27e4e48"},{"last_name":"Zhang","first_name":"Can","full_name":"Zhang, Can"},{"full_name":"Naibert, Tyler","first_name":"Tyler","last_name":"Naibert"},{"full_name":"Eckstein, James","first_name":"James","last_name":"Eckstein"},{"full_name":"Budakian, Raffi","last_name":"Budakian","first_name":"Raffi"}],"oa_version":"Published Version","quality_controlled":"1","article_processing_charge":"No","volume":60,"language":[{"iso":"eng"}],"issue":"1","article_number":"G16.00009","month":"03","main_file_link":[{"url":"https://meetings.aps.org/Meeting/MAR15/Event/238442","open_access":"1"}],"status":"public","publication_identifier":{"issn":["0003-0503"]},"_id":"10748","type":"conference","date_created":"2022-02-08T10:17:09Z","conference":{"location":"San Antonio, TX, United States","name":"APS: American Physical Society","start_date":"2015-03-02","end_date":"2015-03-06"},"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","alternative_title":["Bulletin of the American Physical Society"],"citation":{"apa":"Polshyn, H., Zhang, C., Naibert, T., Eckstein, J., & Budakian, R. (2015). Study of Fe (Se, Te) micron-sized rings by magnetic force microscopy. In APS March Meeting 2015 (Vol. 60). San Antonio, TX, United States: American Physical Society.","chicago":"Polshyn, Hryhoriy, Can Zhang, Tyler Naibert, James Eckstein, and Raffi Budakian. “Study of Fe (Se, Te) Micron-Sized Rings by Magnetic Force Microscopy.” In APS March Meeting 2015, Vol. 60. American Physical Society, 2015.","ista":"Polshyn H, Zhang C, Naibert T, Eckstein J, Budakian R. 2015. Study of Fe (Se, Te) micron-sized rings by magnetic force microscopy. APS March Meeting 2015. APS: American Physical Society, Bulletin of the American Physical Society, vol. 60, G16.00009.","ama":"Polshyn H, Zhang C, Naibert T, Eckstein J, Budakian R. Study of Fe (Se, Te) micron-sized rings by magnetic force microscopy. In: APS March Meeting 2015. Vol 60. American Physical Society; 2015.","ieee":"H. Polshyn, C. Zhang, T. Naibert, J. Eckstein, and R. Budakian, “Study of Fe (Se, Te) micron-sized rings by magnetic force microscopy,” in APS March Meeting 2015, San Antonio, TX, United States, 2015, vol. 60, no. 1.","mla":"Polshyn, Hryhoriy, et al. “Study of Fe (Se, Te) Micron-Sized Rings by Magnetic Force Microscopy.” APS March Meeting 2015, vol. 60, no. 1, G16.00009, American Physical Society, 2015.","short":"H. Polshyn, C. Zhang, T. Naibert, J. Eckstein, R. Budakian, in:, APS March Meeting 2015, American Physical Society, 2015."},"date_updated":"2022-02-08T10:42:53Z","extern":"1","title":"Study of Fe (Se, Te) micron-sized rings by magnetic force microscopy","date_published":"2015-03-01T00:00:00Z","publisher":"American Physical Society","abstract":[{"lang":"eng","text":"The study of fluxoid states and fluxoid dynamics in mesoscopic iron-based superconducting rings is valuable for characterizing the basic properties of the superconductor, and may also provide important insight into the superconducting paring symmetry. We report the fabrications of micron-sized rings and disks from thin films of Fe(Se, Te) grown by molecular beam epitaxy. In order to study fluxoid states in rings we developed a custom-tailored version of magnetic force microscopy (MFM). This technique has a number of qualitative advantages for working with mesoscopic superconducting samples in comparison to the conventional MFM and other imaging techniques. We observed metastable fluxoid states in rings of different sizes. Thermally activated fluxoid dynamics of these states was studied and modeled. In addition, we found different regimes of interaction between Fe(Se, Te) ring and MFM tip which are explained. Possibilities of the existence of exotic vortex states and proposals for experiments to test the symmetry of the superconducting order parameter in iron based superconductors are analyzed."}],"publication_status":"published","day":"01","year":"2015","oa":1,"publication":"APS March Meeting 2015","intvolume":" 60"},{"date_published":"2015-06-10T00:00:00Z","file_date_updated":"2022-02-25T11:55:26Z","publisher":"Frontiers","title":"Bayesian inference for stochastic individual-based models of ecological systems: a pest control simulation study","publication_status":"published","abstract":[{"text":"Mathematical models are of fundamental importance in the understanding of complex population dynamics. For instance, they can be used to predict the population evolution starting from different initial conditions or to test how a system responds to external perturbations. For this analysis to be meaningful in real applications, however, it is of paramount importance to choose an appropriate model structure and to infer the model parameters from measured data. While many parameter inference methods are available for models based on deterministic ordinary differential equations, the same does not hold for more detailed individual-based models. Here we consider, in particular, stochastic models in which the time evolution of the species abundances is described by a continuous-time Markov chain. These models are governed by a master equation that is typically difficult to solve. Consequently, traditional inference methods that rely on iterative evaluation of parameter likelihoods are computationally intractable. The aim of this paper is to present recent advances in parameter inference for continuous-time Markov chain models, based on a moment closure approximation of the parameter likelihood, and to investigate how these results can help in understanding, and ultimately controlling, complex systems in ecology. Specifically, we illustrate through an agricultural pest case study how parameters of a stochastic individual-based model can be identified from measured data and how the resulting model can be used to solve an optimal control problem in a stochastic setting. In particular, we show how the matter of determining the optimal combination of two different pest control methods can be formulated as a chance constrained optimization problem where the control action is modeled as a state reset, leading to a hybrid system formulation.","lang":"eng"}],"ddc":["000","570"],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"ToHe"},{"_id":"GaTk"}],"date_updated":"2022-02-25T11:59:23Z","citation":{"mla":"Parise, Francesca, et al. “Bayesian Inference for Stochastic Individual-Based Models of Ecological Systems: A Pest Control Simulation Study.” Frontiers in Environmental Science, vol. 3, 42, Frontiers, 2015, doi:10.3389/fenvs.2015.00042.","short":"F. Parise, J. Lygeros, J. Ruess, Frontiers in Environmental Science 3 (2015).","ieee":"F. Parise, J. Lygeros, and J. Ruess, “Bayesian inference for stochastic individual-based models of ecological systems: a pest control simulation study,” Frontiers in Environmental Science, vol. 3. Frontiers, 2015.","chicago":"Parise, Francesca, John Lygeros, and Jakob Ruess. “Bayesian Inference for Stochastic Individual-Based Models of Ecological Systems: A Pest Control Simulation Study.” Frontiers in Environmental Science. Frontiers, 2015. https://doi.org/10.3389/fenvs.2015.00042.","ista":"Parise F, Lygeros J, Ruess J. 2015. Bayesian inference for stochastic individual-based models of ecological systems: a pest control simulation study. Frontiers in Environmental Science. 3, 42.","ama":"Parise F, Lygeros J, Ruess J. Bayesian inference for stochastic individual-based models of ecological systems: a pest control simulation study. Frontiers in Environmental Science. 2015;3. doi:10.3389/fenvs.2015.00042","apa":"Parise, F., Lygeros, J., & Ruess, J. (2015). Bayesian inference for stochastic individual-based models of ecological systems: a pest control simulation study. Frontiers in Environmental Science. Frontiers. https://doi.org/10.3389/fenvs.2015.00042"},"intvolume":" 3","publication":"Frontiers in Environmental Science","scopus_import":"1","keyword":["General Environmental Science"],"acknowledgement":"The authors would like to acknowledge contributions from Baptiste Mottet who performed preliminary analysis regarding parameter inference for the considered case study in a student project (Mottet, 2014/2015).\r\nThe research leading to these results has received funding from the People Programme (Marie Curie Actions) of the European Union's Seventh Framework Programme (FP7/2007-2013) under REA grant agreement No. [291734] and from SystemsX under the project SignalX.","year":"2015","doi":"10.3389/fenvs.2015.00042","day":"10","oa":1,"language":[{"iso":"eng"}],"volume":3,"article_processing_charge":"No","month":"06","has_accepted_license":"1","file":[{"success":1,"relation":"main_file","access_level":"open_access","file_size":1371201,"checksum":"26c222487564e1be02a11d688d6f769d","file_id":"10795","creator":"dernst","date_created":"2022-02-25T11:55:26Z","date_updated":"2022-02-25T11:55:26Z","content_type":"application/pdf","file_name":"2015_FrontiersEnvironmScience_Parise.pdf"}],"article_number":"42","author":[{"last_name":"Parise","first_name":"Francesca","full_name":"Parise, Francesca"},{"full_name":"Lygeros, John","first_name":"John","last_name":"Lygeros"},{"orcid":"0000-0003-1615-3282","first_name":"Jakob","last_name":"Ruess","full_name":"Ruess, Jakob","id":"4A245D00-F248-11E8-B48F-1D18A9856A87"}],"project":[{"_id":"25681D80-B435-11E9-9278-68D0E5697425","grant_number":"291734","name":"International IST Postdoc Fellowship Programme","call_identifier":"FP7"}],"quality_controlled":"1","oa_version":"Published Version","ec_funded":1,"status":"public","license":"https://creativecommons.org/licenses/by/4.0/","publication_identifier":{"issn":["2296-665X"]},"date_created":"2022-02-25T11:42:25Z","article_type":"original","_id":"10794","type":"journal_article"},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","external_id":{"arxiv":["1409.6690"]},"citation":{"ieee":"K. Chatterjee and R. Ibsen-Jensen, “The value 1 problem under finite-memory strategies for concurrent mean-payoff games,” in Proceedings of the Twenty-Sixth Annual ACM-SIAM Symposium on Discrete Algorithms, San Diego, CA, United States, 2015, vol. 2015, no. 1, pp. 1018–1029.","chicago":"Chatterjee, Krishnendu, and Rasmus Ibsen-Jensen. “The Value 1 Problem under Finite-Memory Strategies for Concurrent Mean-Payoff Games.” In Proceedings of the Twenty-Sixth Annual ACM-SIAM Symposium on Discrete Algorithms, 2015:1018–29. SIAM, 2015. https://doi.org/10.1137/1.9781611973730.69.","ista":"Chatterjee K, Ibsen-Jensen R. 2015. The value 1 problem under finite-memory strategies for concurrent mean-payoff games. Proceedings of the Twenty-Sixth Annual ACM-SIAM Symposium on Discrete Algorithms. SODA: Symposium on Discrete Algorithms vol. 2015, 1018–1029.","ama":"Chatterjee K, Ibsen-Jensen R. The value 1 problem under finite-memory strategies for concurrent mean-payoff games. In: Proceedings of the Twenty-Sixth Annual ACM-SIAM Symposium on Discrete Algorithms. Vol 2015. SIAM; 2015:1018-1029. doi:10.1137/1.9781611973730.69","apa":"Chatterjee, K., & Ibsen-Jensen, R. (2015). The value 1 problem under finite-memory strategies for concurrent mean-payoff games. In Proceedings of the Twenty-Sixth Annual ACM-SIAM Symposium on Discrete Algorithms (Vol. 2015, pp. 1018–1029). San Diego, CA, United States: SIAM. https://doi.org/10.1137/1.9781611973730.69","mla":"Chatterjee, Krishnendu, and Rasmus Ibsen-Jensen. “The Value 1 Problem under Finite-Memory Strategies for Concurrent Mean-Payoff Games.” Proceedings of the Twenty-Sixth Annual ACM-SIAM Symposium on Discrete Algorithms, vol. 2015, no. 1, SIAM, 2015, pp. 1018–29, doi:10.1137/1.9781611973730.69.","short":"K. Chatterjee, R. Ibsen-Jensen, in:, Proceedings of the Twenty-Sixth Annual ACM-SIAM Symposium on Discrete Algorithms, SIAM, 2015, pp. 1018–1029."},"date_updated":"2022-02-25T12:33:32Z","department":[{"_id":"KrCh"}],"title":"The value 1 problem under finite-memory strategies for concurrent mean-payoff games","publisher":"SIAM","date_published":"2015-01-01T00:00:00Z","abstract":[{"lang":"eng","text":"We consider concurrent mean-payoff games, a very well-studied class of two-player (player 1 vs player 2) zero-sum games on finite-state graphs where every transition is assigned a reward between 0 and 1, and the payoff function is the long-run average of the rewards. The value is the maximal expected payoff that player 1 can guarantee against all strategies of player 2. We consider the computation of the set of states with value 1 under finite-memory strategies for player 1, and our main results for the problem are as follows: (1) we present a polynomial-time algorithm; (2) we show that whenever there is a finite-memory strategy, there is a stationary strategy that does not need memory at all; and (3) we present an optimal bound (which is double exponential) on the patience of stationary strategies (where patience of a distribution is the inverse of the smallest positive probability and represents a complexity measure of a stationary strategy)."}],"publication_status":"published","day":"01","doi":"10.1137/1.9781611973730.69","page":"1018-1029","year":"2015","acknowledgement":"The research was partly supported by FWF Grant No P 23499-N23, FWF NFN Grant\r\nNo S11407-N23 (RiSE), ERC Start grant (279307: Graph Games), and Microsoft faculty fellows award.","publication":"Proceedings of the Twenty-Sixth Annual ACM-SIAM Symposium on Discrete Algorithms","intvolume":" 2015","arxiv":1,"scopus_import":"1","author":[{"full_name":"Chatterjee, Krishnendu","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4561-241X","first_name":"Krishnendu","last_name":"Chatterjee"},{"id":"3B699956-F248-11E8-B48F-1D18A9856A87","full_name":"Ibsen-Jensen, Rasmus","last_name":"Ibsen-Jensen","first_name":"Rasmus","orcid":"0000-0003-4783-0389"}],"oa_version":"Preprint","quality_controlled":"1","project":[{"call_identifier":"FWF","_id":"2584A770-B435-11E9-9278-68D0E5697425","grant_number":"P 23499-N23","name":"Modern Graph Algorithmic Techniques in Formal Verification"},{"call_identifier":"FWF","grant_number":"S11407","_id":"25863FF4-B435-11E9-9278-68D0E5697425","name":"Game Theory"},{"_id":"2581B60A-B435-11E9-9278-68D0E5697425","grant_number":"279307","name":"Quantitative Graph Games: Theory and Applications","call_identifier":"FP7"},{"name":"Microsoft Research Faculty Fellowship","_id":"2587B514-B435-11E9-9278-68D0E5697425"}],"article_processing_charge":"No","volume":2015,"language":[{"iso":"eng"}],"issue":"1","month":"01","publication_identifier":{"isbn":["978-161197374-7"]},"status":"public","_id":"10796","type":"conference","date_created":"2022-02-25T12:18:43Z","ec_funded":1,"conference":{"location":"San Diego, CA, United States","name":"SODA: Symposium on Discrete Algorithms","start_date":"2015-01-04","end_date":"2015-01-06"}},{"abstract":[{"lang":"eng","text":"Circumferential skin creases Kunze type (CSC-KT) is a specific congenital entity with an unknown genetic cause. The disease phenotype comprises characteristic circumferential skin creases accompanied by intellectual disability, a cleft palate, short stature, and dysmorphic features. Here, we report that mutations in either MAPRE2 or TUBB underlie the genetic origin of this syndrome. MAPRE2 encodes a member of the microtubule end-binding family of proteins that bind to the guanosine triphosphate cap at growing microtubule plus ends, and TUBB encodes a β-tubulin isotype that is expressed abundantly in the developing brain. Functional analyses of the TUBB mutants show multiple defects in the chaperone-dependent tubulin heterodimer folding and assembly pathway that leads to a compromised yield of native heterodimers. The TUBB mutations also have an impact on microtubule dynamics. For MAPRE2, we show that the mutations result in enhanced MAPRE2 binding to microtubules, implying an increased dwell time at microtubule plus ends. Further, in vivo analysis of MAPRE2 mutations in a zebrafish model of craniofacial development shows that the variants most likely perturb the patterning of branchial arches, either through excessive activity (under a recessive paradigm) or through haploinsufficiency (dominant de novo paradigm). Taken together, our data add CSC-KT to the growing list of tubulinopathies and highlight how multiple inheritance paradigms can affect dosage-sensitive biological systems so as to result in the same clinical defect."}],"month":"12","publication_status":"published","issue":"6","date_published":"2015-12-03T00:00:00Z","publisher":"Cell Press","language":[{"iso":"eng"}],"volume":97,"title":"Mutations in either TUBB or MAPRE2 cause circumferential skin creases Kunze type","date_updated":"2021-01-12T06:48:19Z","extern":"1","quality_controlled":"1","oa_version":"None","citation":{"mla":"Isrie, Mala, et al. “Mutations in Either TUBB or MAPRE2 Cause Circumferential Skin Creases Kunze Type.” The American Journal of Human Genetics, vol. 97, no. 6, Cell Press, 2015, pp. 790–800, doi:10.1016/j.ajhg.2015.10.014.","short":"M. Isrie, M. Breuss, G. Tian, A.H. Hansen, F. Cristofoli, J. Morandell, Z.A. Kupchinsky, A. Sifrim, C. Rodriguez Rodriguez, E.P. Dapena, K. Doonanco, N. Leonard, F. Tinsa, S. Moortgat, H. Ulucan, E. Koparir, E. Karaca, N. Katsanis, V. Marton, J.R. Vermeesch, E.E. Davis, N.J. Cowan, D. Keays, H. Van Esch, The American Journal of Human Genetics 97 (2015) 790–800.","ieee":"M. Isrie et al., “Mutations in either TUBB or MAPRE2 cause circumferential skin creases Kunze type,” The American Journal of Human Genetics, vol. 97, no. 6. Cell Press, pp. 790–800, 2015.","apa":"Isrie, M., Breuss, M., Tian, G., Hansen, A. H., Cristofoli, F., Morandell, J., … Van Esch, H. (2015). Mutations in either TUBB or MAPRE2 cause circumferential skin creases Kunze type. The American Journal of Human Genetics. Cell Press. https://doi.org/10.1016/j.ajhg.2015.10.014","ista":"Isrie M, Breuss M, Tian G, Hansen AH, Cristofoli F, Morandell J, Kupchinsky ZA, Sifrim A, Rodriguez Rodriguez C, Dapena EP, Doonanco K, Leonard N, Tinsa F, Moortgat S, Ulucan H, Koparir E, Karaca E, Katsanis N, Marton V, Vermeesch JR, Davis EE, Cowan NJ, Keays D, Van Esch H. 2015. Mutations in either TUBB or MAPRE2 cause circumferential skin creases Kunze type. The American Journal of Human Genetics. 97(6), 790–800.","ama":"Isrie M, Breuss M, Tian G, et al. Mutations in either TUBB or MAPRE2 cause circumferential skin creases Kunze type. The American Journal of Human Genetics. 2015;97(6):790-800. doi:10.1016/j.ajhg.2015.10.014","chicago":"Isrie, Mala, Martin Breuss, Guoling Tian, Andi H Hansen, Francesca Cristofoli, Jasmin Morandell, Zachari A Kupchinsky, et al. “Mutations in Either TUBB or MAPRE2 Cause Circumferential Skin Creases Kunze Type.” The American Journal of Human Genetics. Cell Press, 2015. https://doi.org/10.1016/j.ajhg.2015.10.014."},"author":[{"last_name":"Isrie","first_name":"Mala","full_name":"Isrie, Mala"},{"first_name":"Martin","last_name":"Breuss","full_name":"Breuss, Martin"},{"first_name":"Guoling","last_name":"Tian","full_name":"Tian, Guoling"},{"id":"38853E16-F248-11E8-B48F-1D18A9856A87","full_name":"Hansen, Andi H","last_name":"Hansen","first_name":"Andi H"},{"full_name":"Cristofoli, Francesca","last_name":"Cristofoli","first_name":"Francesca"},{"last_name":"Morandell","first_name":"Jasmin","id":"4739D480-F248-11E8-B48F-1D18A9856A87","full_name":"Morandell, Jasmin"},{"last_name":"Kupchinsky","first_name":"Zachari A","full_name":"Kupchinsky, Zachari A"},{"full_name":"Sifrim, Alejandro","last_name":"Sifrim","first_name":"Alejandro"},{"full_name":"Rodriguez Rodriguez, Celia","first_name":"Celia","last_name":"Rodriguez Rodriguez"},{"first_name":"Elena P","last_name":"Dapena","full_name":"Dapena, Elena P"},{"full_name":"Doonanco, Kurston","first_name":"Kurston","last_name":"Doonanco"},{"last_name":"Leonard","first_name":"Norma","full_name":"Leonard, Norma"},{"last_name":"Tinsa","first_name":"Faten","full_name":"Tinsa, Faten"},{"full_name":"Moortgat, Stéphanie","first_name":"Stéphanie","last_name":"Moortgat"},{"full_name":"Ulucan, Hakan","last_name":"Ulucan","first_name":"Hakan"},{"first_name":"Erkan","last_name":"Koparir","full_name":"Koparir, Erkan"},{"full_name":"Karaca, Ender","last_name":"Karaca","first_name":"Ender"},{"last_name":"Katsanis","first_name":"Nicholas","full_name":"Katsanis, Nicholas"},{"full_name":"Marton, Valeria","last_name":"Marton","first_name":"Valeria"},{"full_name":"Vermeesch, Joris R","last_name":"Vermeesch","first_name":"Joris R"},{"full_name":"Davis, Erica E","last_name":"Davis","first_name":"Erica E"},{"first_name":"Nicholas J","last_name":"Cowan","full_name":"Cowan, Nicholas J"},{"first_name":"David","last_name":"Keays","full_name":"Keays, David"},{"full_name":"Van Esch, Hilde","last_name":"Van Esch","first_name":"Hilde"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":" 97","publist_id":"6264","publication":"The American Journal of Human Genetics","date_created":"2018-12-11T11:50:11Z","_id":"1106","type":"journal_article","doi":"10.1016/j.ajhg.2015.10.014","page":"790 - 800","year":"2015","status":"public","day":"03"},{"issue":"7","month":"06","volume":161,"article_processing_charge":"No","language":[{"iso":"eng"}],"oa_version":"Published Version","quality_controlled":"1","author":[{"first_name":"Emily M.","last_name":"Hatch","full_name":"Hatch, Emily M."},{"orcid":"0000-0002-2111-992X","last_name":"HETZER","first_name":"Martin W","full_name":"HETZER, Martin W","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed"}],"article_type":"original","type":"journal_article","_id":"11073","date_created":"2022-04-07T07:48:49Z","main_file_link":[{"url":"https://doi.org/10.1016/j.cell.2015.06.005","open_access":"1"}],"publication_identifier":{"issn":["0092-8674"]},"status":"public","publication_status":"published","abstract":[{"lang":"eng","text":"Human cancer cells bear complex chromosome rearrangements that can be potential drivers of cancer development. However, the molecular mechanisms underlying these rearrangements have been unclear. Zhang et al. use a new technique combining live-cell imaging and single-cell sequencing to demonstrate that chromosomes mis-segregated to micronuclei frequently undergo chromothripsis-like rearrangements in the subsequent cell cycle."}],"title":"Linking micronuclei to chromosome fragmentation","pmid":1,"date_published":"2015-06-18T00:00:00Z","publisher":"Elsevier","citation":{"mla":"Hatch, Emily M., and Martin Hetzer. “Linking Micronuclei to Chromosome Fragmentation.” Cell, vol. 161, no. 7, Elsevier, 2015, pp. 1502–04, doi:10.1016/j.cell.2015.06.005.","short":"E.M. Hatch, M. Hetzer, Cell 161 (2015) 1502–1504.","ieee":"E. M. Hatch and M. Hetzer, “Linking micronuclei to chromosome fragmentation,” Cell, vol. 161, no. 7. Elsevier, pp. 1502–1504, 2015.","chicago":"Hatch, Emily M., and Martin Hetzer. “Linking Micronuclei to Chromosome Fragmentation.” Cell. Elsevier, 2015. https://doi.org/10.1016/j.cell.2015.06.005.","ama":"Hatch EM, Hetzer M. Linking micronuclei to chromosome fragmentation. Cell. 2015;161(7):1502-1504. doi:10.1016/j.cell.2015.06.005","ista":"Hatch EM, Hetzer M. 2015. Linking micronuclei to chromosome fragmentation. Cell. 161(7), 1502–1504.","apa":"Hatch, E. M., & Hetzer, M. (2015). Linking micronuclei to chromosome fragmentation. Cell. Elsevier. https://doi.org/10.1016/j.cell.2015.06.005"},"extern":"1","date_updated":"2022-07-18T08:34:33Z","external_id":{"pmid":["26091034"]},"user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","keyword":["General Biochemistry","Genetics and Molecular Biology"],"scopus_import":"1","publication":"Cell","intvolume":" 161","oa":1,"year":"2015","doi":"10.1016/j.cell.2015.06.005","page":"1502-1504","day":"18"},{"author":[{"first_name":"Emily M.","last_name":"Hatch","full_name":"Hatch, Emily M."},{"last_name":"HETZER","first_name":"Martin W","orcid":"0000-0002-2111-992X","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","full_name":"HETZER, Martin W"}],"quality_controlled":"1","oa_version":"Published Version","language":[{"iso":"eng"}],"volume":25,"article_processing_charge":"No","month":"05","issue":"10","status":"public","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1016/j.cub.2015.02.033"}],"publication_identifier":{"issn":["0960-9822"]},"date_created":"2022-04-07T07:49:00Z","article_type":"original","_id":"11074","type":"journal_article","external_id":{"pmid":["25989073"]},"user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","extern":"1","date_updated":"2022-07-18T08:34:34Z","citation":{"apa":"Hatch, E. M., & Hetzer, M. (2015). Chromothripsis. Current Biology. Elsevier. https://doi.org/10.1016/j.cub.2015.02.033","ama":"Hatch EM, Hetzer M. Chromothripsis. Current Biology. 2015;25(10):PR397-R399. doi:10.1016/j.cub.2015.02.033","ista":"Hatch EM, Hetzer M. 2015. Chromothripsis. Current Biology. 25(10), PR397-R399.","chicago":"Hatch, Emily M., and Martin Hetzer. “Chromothripsis.” Current Biology. Elsevier, 2015. https://doi.org/10.1016/j.cub.2015.02.033.","ieee":"E. M. Hatch and M. Hetzer, “Chromothripsis,” Current Biology, vol. 25, no. 10. Elsevier, pp. PR397-R399, 2015.","mla":"Hatch, Emily M., and Martin Hetzer. “Chromothripsis.” Current Biology, vol. 25, no. 10, Elsevier, 2015, pp. PR397-R399, doi:10.1016/j.cub.2015.02.033.","short":"E.M. Hatch, M. Hetzer, Current Biology 25 (2015) PR397-R399."},"pmid":1,"publisher":"Elsevier","date_published":"2015-05-18T00:00:00Z","title":"Chromothripsis","publication_status":"published","year":"2015","page":"PR397-R399","doi":"10.1016/j.cub.2015.02.033","day":"18","oa":1,"intvolume":" 25","publication":"Current Biology","scopus_import":"1","keyword":["General Agricultural and Biological Sciences","General Biochemistry","Genetics and Molecular Biology"]},{"author":[{"first_name":"J. Sebastian","last_name":"Gomez-Cavazos","full_name":"Gomez-Cavazos, J. Sebastian"},{"full_name":"HETZER, Martin W","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","orcid":"0000-0002-2111-992X","last_name":"HETZER","first_name":"Martin W"}],"oa_version":"Published Version","quality_controlled":"1","article_processing_charge":"No","volume":208,"language":[{"iso":"eng"}],"issue":"6","month":"03","publication_identifier":{"eissn":["1540-8140"],"issn":["0021-9525"]},"status":"public","_id":"11075","type":"journal_article","article_type":"original","date_created":"2022-04-07T07:49:10Z","user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","external_id":{"pmid":["25778917"]},"citation":{"ama":"Gomez-Cavazos JS, Hetzer M. The nucleoporin gp210/Nup210 controls muscle differentiation by regulating nuclear envelope/ER homeostasis. Journal of Cell Biology. 2015;208(6):671-681. doi:10.1083/jcb.201410047","ista":"Gomez-Cavazos JS, Hetzer M. 2015. The nucleoporin gp210/Nup210 controls muscle differentiation by regulating nuclear envelope/ER homeostasis. Journal of Cell Biology. 208(6), 671–681.","chicago":"Gomez-Cavazos, J. Sebastian, and Martin Hetzer. “The Nucleoporin Gp210/Nup210 Controls Muscle Differentiation by Regulating Nuclear Envelope/ER Homeostasis.” Journal of Cell Biology. Rockefeller University Press, 2015. https://doi.org/10.1083/jcb.201410047.","apa":"Gomez-Cavazos, J. S., & Hetzer, M. (2015). The nucleoporin gp210/Nup210 controls muscle differentiation by regulating nuclear envelope/ER homeostasis. Journal of Cell Biology. Rockefeller University Press. https://doi.org/10.1083/jcb.201410047","ieee":"J. S. Gomez-Cavazos and M. Hetzer, “The nucleoporin gp210/Nup210 controls muscle differentiation by regulating nuclear envelope/ER homeostasis,” Journal of Cell Biology, vol. 208, no. 6. Rockefeller University Press, pp. 671–681, 2015.","short":"J.S. Gomez-Cavazos, M. Hetzer, Journal of Cell Biology 208 (2015) 671–681.","mla":"Gomez-Cavazos, J. Sebastian, and Martin Hetzer. “The Nucleoporin Gp210/Nup210 Controls Muscle Differentiation by Regulating Nuclear Envelope/ER Homeostasis.” Journal of Cell Biology, vol. 208, no. 6, Rockefeller University Press, 2015, pp. 671–81, doi:10.1083/jcb.201410047."},"date_updated":"2022-07-18T08:43:00Z","extern":"1","title":"The nucleoporin gp210/Nup210 controls muscle differentiation by regulating nuclear envelope/ER homeostasis","date_published":"2015-03-16T00:00:00Z","publisher":"Rockefeller University Press","pmid":1,"abstract":[{"lang":"eng","text":"Previously, we identified the nucleoporin gp210/Nup210 as a critical regulator of muscle and neuronal differentiation, but how this nucleoporin exerts its function and whether it modulates nuclear pore complex (NPC) activity remain unknown. Here, we show that gp210/Nup210 mediates muscle cell differentiation in vitro via its conserved N-terminal domain that extends into the perinuclear space. Removal of the C-terminal domain, which partially mislocalizes gp210/Nup210 away from NPCs, efficiently rescues the differentiation defect caused by the knockdown of endogenous gp210/Nup210. Unexpectedly, a gp210/Nup210 mutant lacking the NPC-targeting transmembrane and C-terminal domains is sufficient for C2C12 myoblast differentiation. We demonstrate that the endoplasmic reticulum (ER) stress-specific caspase cascade is exacerbated during Nup210 depletion and that blocking ER stress-mediated apoptosis rescues differentiation of Nup210-deficient cells. Our results suggest that the role of gp210/Nup210 in cell differentiation is mediated by its large luminal domain, which can act independently of NPC association and appears to play a pivotal role in the maintenance of nuclear envelope/ER homeostasis."}],"publication_status":"published","day":"16","year":"2015","page":"671-681","doi":"10.1083/jcb.201410047","publication":"Journal of Cell Biology","intvolume":" 208","scopus_import":"1","keyword":["Cell Biology"]},{"quality_controlled":"1","oa_version":"Published Version","author":[{"full_name":"Ibarra, Arkaitz","last_name":"Ibarra","first_name":"Arkaitz"},{"orcid":"0000-0002-2111-992X","last_name":"HETZER","first_name":"Martin W","full_name":"HETZER, Martin W","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed"}],"month":"02","issue":"4","language":[{"iso":"eng"}],"volume":29,"article_processing_charge":"No","date_created":"2022-04-07T07:49:21Z","article_type":"original","type":"journal_article","_id":"11076","status":"public","main_file_link":[{"url":"https://doi.org/10.1101/gad.256495.114","open_access":"1"}],"publication_identifier":{"eissn":["1549-5477"],"issn":["0890-9369"]},"extern":"1","date_updated":"2022-07-18T08:43:20Z","citation":{"short":"A. Ibarra, M. Hetzer, Genes & Development 29 (2015) 337–349.","mla":"Ibarra, Arkaitz, and Martin Hetzer. “Nuclear Pore Proteins and the Control of Genome Functions.” Genes & Development, vol. 29, no. 4, Cold Spring Harbor Laboratory, 2015, pp. 337–49, doi:10.1101/gad.256495.114.","ama":"Ibarra A, Hetzer M. Nuclear pore proteins and the control of genome functions. Genes & Development. 2015;29(4):337-349. doi:10.1101/gad.256495.114","ista":"Ibarra A, Hetzer M. 2015. Nuclear pore proteins and the control of genome functions. Genes & Development. 29(4), 337–349.","chicago":"Ibarra, Arkaitz, and Martin Hetzer. “Nuclear Pore Proteins and the Control of Genome Functions.” Genes & Development. Cold Spring Harbor Laboratory, 2015. https://doi.org/10.1101/gad.256495.114.","apa":"Ibarra, A., & Hetzer, M. (2015). Nuclear pore proteins and the control of genome functions. Genes & Development. Cold Spring Harbor Laboratory. https://doi.org/10.1101/gad.256495.114","ieee":"A. Ibarra and M. Hetzer, “Nuclear pore proteins and the control of genome functions,” Genes & Development, vol. 29, no. 4. Cold Spring Harbor Laboratory, pp. 337–349, 2015."},"external_id":{"pmid":["25691464"]},"user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","publication_status":"published","abstract":[{"lang":"eng","text":"Nuclear pore complexes (NPCs) are composed of several copies of ∼30 different proteins called nucleoporins (Nups). NPCs penetrate the nuclear envelope (NE) and regulate the nucleocytoplasmic trafficking of macromolecules. Beyond this vital role, NPC components influence genome functions in a transport-independent manner. Nups play an evolutionarily conserved role in gene expression regulation that, in metazoans, extends into the nuclear interior. Additionally, in proliferative cells, Nups play a crucial role in genome integrity maintenance and mitotic progression. Here we discuss genome-related functions of Nups and their impact on essential DNA metabolism processes such as transcription, chromosome duplication, and segregation."}],"pmid":1,"date_published":"2015-02-01T00:00:00Z","publisher":"Cold Spring Harbor Laboratory","title":"Nuclear pore proteins and the control of genome functions","oa":1,"day":"01","doi":"10.1101/gad.256495.114","page":"337-349","year":"2015","keyword":["Developmental Biology","Genetics"],"scopus_import":"1","intvolume":" 29","publication":"Genes & Development"},{"author":[{"full_name":"Jacinto, Filipe V.","first_name":"Filipe V.","last_name":"Jacinto"},{"first_name":"Chris","last_name":"Benner","full_name":"Benner, Chris"},{"full_name":"HETZER, Martin W","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","orcid":"0000-0002-2111-992X","first_name":"Martin W","last_name":"HETZER"}],"oa_version":"Published Version","quality_controlled":"1","volume":29,"article_processing_charge":"No","language":[{"iso":"eng"}],"issue":"12","month":"06","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1101/gad.260919.115"}],"publication_identifier":{"issn":["0890-9369"],"eissn":["1549-5477"]},"status":"public","article_type":"original","_id":"11077","type":"journal_article","date_created":"2022-04-07T07:49:31Z","external_id":{"pmid":["26080816"]},"user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","citation":{"short":"F.V. Jacinto, C. Benner, M. Hetzer, Genes & Development 29 (2015) 1224–1238.","mla":"Jacinto, Filipe V., et al. “The Nucleoporin Nup153 Regulates Embryonic Stem Cell Pluripotency through Gene Silencing.” Genes & Development, vol. 29, no. 12, Cold Spring Harbor Laboratory, 2015, pp. 1224–38, doi:10.1101/gad.260919.115.","ama":"Jacinto FV, Benner C, Hetzer M. The nucleoporin Nup153 regulates embryonic stem cell pluripotency through gene silencing. Genes & Development. 2015;29(12):1224-1238. doi:10.1101/gad.260919.115","chicago":"Jacinto, Filipe V., Chris Benner, and Martin Hetzer. “The Nucleoporin Nup153 Regulates Embryonic Stem Cell Pluripotency through Gene Silencing.” Genes & Development. Cold Spring Harbor Laboratory, 2015. https://doi.org/10.1101/gad.260919.115.","ista":"Jacinto FV, Benner C, Hetzer M. 2015. The nucleoporin Nup153 regulates embryonic stem cell pluripotency through gene silencing. Genes & Development. 29(12), 1224–1238.","apa":"Jacinto, F. V., Benner, C., & Hetzer, M. (2015). The nucleoporin Nup153 regulates embryonic stem cell pluripotency through gene silencing. Genes & Development. Cold Spring Harbor Laboratory. https://doi.org/10.1101/gad.260919.115","ieee":"F. V. Jacinto, C. Benner, and M. Hetzer, “The nucleoporin Nup153 regulates embryonic stem cell pluripotency through gene silencing,” Genes & Development, vol. 29, no. 12. Cold Spring Harbor Laboratory, pp. 1224–1238, 2015."},"extern":"1","date_updated":"2022-07-18T08:43:51Z","title":"The nucleoporin Nup153 regulates embryonic stem cell pluripotency through gene silencing","pmid":1,"date_published":"2015-06-16T00:00:00Z","publisher":"Cold Spring Harbor Laboratory","publication_status":"published","abstract":[{"text":"Nucleoporins (Nups) are a family of proteins best known as the constituent building blocks of nuclear pore complexes (NPCs), membrane-embedded channels that mediate nuclear transport across the nuclear envelope. Recent evidence suggests that several Nups have additional roles in controlling the activation and silencing of developmental genes; however, the mechanistic details of these functions remain poorly understood. Here, we show that depletion of Nup153 in mouse embryonic stem cells (mESCs) causes the derepression of developmental genes and induction of early differentiation. This loss of stem cell identity is not associated with defects in the nuclear import of key pluripotency factors. Rather, Nup153 binds around the transcriptional start site (TSS) of developmental genes and mediates the recruitment of the polycomb-repressive complex 1 (PRC1) to a subset of its target loci. Our results demonstrate a chromatin-associated role of Nup153 in maintaining stem cell pluripotency by functioning in mammalian epigenetic gene silencing.","lang":"eng"}],"doi":"10.1101/gad.260919.115","day":"16","page":"1224-1238","year":"2015","oa":1,"publication":"Genes & Development","intvolume":" 29","keyword":["Developmental Biology","Genetics"],"scopus_import":"1"},{"title":"Integrated transcriptome and proteome analyses reveal organ-specific proteome deterioration in old rats","publisher":"Elsevier","date_published":"2015-09-23T00:00:00Z","pmid":1,"abstract":[{"lang":"eng","text":"Aging is associated with the decline of protein, cell, and organ function. Here, we use an integrated approach to characterize gene expression, bulk translation, and cell biology in the brains and livers of young and old rats. We identify 468 differences in protein abundance between young and old animals. The majority are a consequence of altered translation output, that is, the combined effect of changes in transcript abundance and translation efficiency. In addition, we identify 130 proteins whose overall abundance remains unchanged but whose sub-cellular localization, phosphorylation state, or splice-form varies. While some protein-level differences appear to be a generic property of the rats’ chronological age, the majority are specific to one organ. These may be a consequence of the organ’s physiology or the chronological age of the cells within the tissue. Taken together, our study provides an initial view of the proteome at the molecular, sub-cellular, and organ level in young and old rats."}],"publication_status":"published","user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","external_id":{"pmid":["27135913"]},"citation":{"short":"A. Ori, B.H. Toyama, M.S. Harris, T. Bock, M. Iskar, P. Bork, N.T. Ingolia, M. Hetzer, M. Beck, Cell Systems 1 (2015) P224-237.","mla":"Ori, Alessandro, et al. “Integrated Transcriptome and Proteome Analyses Reveal Organ-Specific Proteome Deterioration in Old Rats.” Cell Systems, vol. 1, no. 3, Elsevier, 2015, pp. P224-237, doi:10.1016/j.cels.2015.08.012.","chicago":"Ori, Alessandro, Brandon H. Toyama, Michael S. Harris, Thomas Bock, Murat Iskar, Peer Bork, Nicholas T. Ingolia, Martin Hetzer, and Martin Beck. “Integrated Transcriptome and Proteome Analyses Reveal Organ-Specific Proteome Deterioration in Old Rats.” Cell Systems. Elsevier, 2015. https://doi.org/10.1016/j.cels.2015.08.012.","ista":"Ori A, Toyama BH, Harris MS, Bock T, Iskar M, Bork P, Ingolia NT, Hetzer M, Beck M. 2015. Integrated transcriptome and proteome analyses reveal organ-specific proteome deterioration in old rats. Cell Systems. 1(3), P224-237.","ama":"Ori A, Toyama BH, Harris MS, et al. Integrated transcriptome and proteome analyses reveal organ-specific proteome deterioration in old rats. Cell Systems. 2015;1(3):P224-237. doi:10.1016/j.cels.2015.08.012","apa":"Ori, A., Toyama, B. H., Harris, M. S., Bock, T., Iskar, M., Bork, P., … Beck, M. (2015). Integrated transcriptome and proteome analyses reveal organ-specific proteome deterioration in old rats. Cell Systems. Elsevier. https://doi.org/10.1016/j.cels.2015.08.012","ieee":"A. Ori et al., “Integrated transcriptome and proteome analyses reveal organ-specific proteome deterioration in old rats,” Cell Systems, vol. 1, no. 3. Elsevier, pp. P224-237, 2015."},"date_updated":"2022-07-18T08:44:07Z","extern":"1","publication":"Cell Systems","intvolume":" 1","keyword":["Cell Biology","Histology","Pathology and Forensic Medicine"],"scopus_import":"1","page":"P224-237","doi":"10.1016/j.cels.2015.08.012","day":"23","year":"2015","oa":1,"article_processing_charge":"No","volume":1,"language":[{"iso":"eng"}],"issue":"3","month":"09","author":[{"full_name":"Ori, Alessandro","last_name":"Ori","first_name":"Alessandro"},{"first_name":"Brandon H.","last_name":"Toyama","full_name":"Toyama, Brandon H."},{"full_name":"Harris, Michael S.","first_name":"Michael S.","last_name":"Harris"},{"full_name":"Bock, Thomas","first_name":"Thomas","last_name":"Bock"},{"last_name":"Iskar","first_name":"Murat","full_name":"Iskar, Murat"},{"last_name":"Bork","first_name":"Peer","full_name":"Bork, Peer"},{"full_name":"Ingolia, Nicholas T.","first_name":"Nicholas T.","last_name":"Ingolia"},{"orcid":"0000-0002-2111-992X","first_name":"Martin W","last_name":"HETZER","full_name":"HETZER, Martin W","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed"},{"full_name":"Beck, Martin","first_name":"Martin","last_name":"Beck"}],"oa_version":"Published Version","quality_controlled":"1","main_file_link":[{"url":"https://doi.org/10.1016/j.cels.2015.08.012","open_access":"1"}],"status":"public","publication_identifier":{"issn":["2405-4712"]},"type":"journal_article","_id":"11078","article_type":"original","date_created":"2022-04-07T07:49:39Z"},{"oa_version":"Published Version","quality_controlled":"1","author":[{"full_name":"Mertens, Jerome","last_name":"Mertens","first_name":"Jerome"},{"first_name":"Apuã C.M.","last_name":"Paquola","full_name":"Paquola, Apuã C.M."},{"first_name":"Manching","last_name":"Ku","full_name":"Ku, Manching"},{"full_name":"Hatch, Emily","first_name":"Emily","last_name":"Hatch"},{"last_name":"Böhnke","first_name":"Lena","full_name":"Böhnke, Lena"},{"last_name":"Ladjevardi","first_name":"Shauheen","full_name":"Ladjevardi, Shauheen"},{"full_name":"McGrath, Sean","first_name":"Sean","last_name":"McGrath"},{"first_name":"Benjamin","last_name":"Campbell","full_name":"Campbell, Benjamin"},{"last_name":"Lee","first_name":"Hyungjun","full_name":"Lee, Hyungjun"},{"full_name":"Herdy, Joseph R.","last_name":"Herdy","first_name":"Joseph R."},{"full_name":"Gonçalves, J. Tiago","first_name":"J. Tiago","last_name":"Gonçalves"},{"first_name":"Tomohisa","last_name":"Toda","full_name":"Toda, Tomohisa"},{"full_name":"Kim, Yongsung","last_name":"Kim","first_name":"Yongsung"},{"full_name":"Winkler, Jürgen","first_name":"Jürgen","last_name":"Winkler"},{"first_name":"Jun","last_name":"Yao","full_name":"Yao, Jun"},{"id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","full_name":"HETZER, Martin W","last_name":"HETZER","first_name":"Martin W","orcid":"0000-0002-2111-992X"},{"full_name":"Gage, Fred H.","first_name":"Fred H.","last_name":"Gage"}],"issue":"6","month":"12","article_processing_charge":"No","volume":17,"language":[{"iso":"eng"}],"_id":"11079","type":"journal_article","article_type":"original","date_created":"2022-04-07T07:49:51Z","status":"public","publication_identifier":{"issn":["1934-5909"]},"main_file_link":[{"url":"https://doi.org/10.1016/j.stem.2015.09.001","open_access":"1"}],"citation":{"ieee":"J. Mertens et al., “Directly reprogrammed human neurons retain aging-associated transcriptomic signatures and reveal age-related nucleocytoplasmic defects,” Cell Stem Cell, vol. 17, no. 6. Elsevier, pp. 705–718, 2015.","ama":"Mertens J, Paquola ACM, Ku M, et al. Directly reprogrammed human neurons retain aging-associated transcriptomic signatures and reveal age-related nucleocytoplasmic defects. Cell Stem Cell. 2015;17(6):705-718. doi:10.1016/j.stem.2015.09.001","ista":"Mertens J, Paquola ACM, Ku M, Hatch E, Böhnke L, Ladjevardi S, McGrath S, Campbell B, Lee H, Herdy JR, Gonçalves JT, Toda T, Kim Y, Winkler J, Yao J, Hetzer M, Gage FH. 2015. Directly reprogrammed human neurons retain aging-associated transcriptomic signatures and reveal age-related nucleocytoplasmic defects. Cell Stem Cell. 17(6), 705–718.","chicago":"Mertens, Jerome, Apuã C.M. Paquola, Manching Ku, Emily Hatch, Lena Böhnke, Shauheen Ladjevardi, Sean McGrath, et al. “Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects.” Cell Stem Cell. Elsevier, 2015. https://doi.org/10.1016/j.stem.2015.09.001.","apa":"Mertens, J., Paquola, A. C. M., Ku, M., Hatch, E., Böhnke, L., Ladjevardi, S., … Gage, F. H. (2015). Directly reprogrammed human neurons retain aging-associated transcriptomic signatures and reveal age-related nucleocytoplasmic defects. Cell Stem Cell. Elsevier. https://doi.org/10.1016/j.stem.2015.09.001","mla":"Mertens, Jerome, et al. “Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects.” Cell Stem Cell, vol. 17, no. 6, Elsevier, 2015, pp. 705–18, doi:10.1016/j.stem.2015.09.001.","short":"J. Mertens, A.C.M. Paquola, M. Ku, E. Hatch, L. Böhnke, S. Ladjevardi, S. McGrath, B. Campbell, H. Lee, J.R. Herdy, J.T. Gonçalves, T. Toda, Y. Kim, J. Winkler, J. Yao, M. Hetzer, F.H. Gage, Cell Stem Cell 17 (2015) 705–718."},"date_updated":"2022-07-18T08:44:21Z","extern":"1","user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","external_id":{"pmid":["26456686"]},"abstract":[{"text":"Aging is a major risk factor for many human diseases, and in vitro generation of human neurons is an attractive approach for modeling aging-related brain disorders. However, modeling aging in differentiated human neurons has proved challenging. We generated neurons from human donors across a broad range of ages, either by iPSC-based reprogramming and differentiation or by direct conversion into induced neurons (iNs). While iPSCs and derived neurons did not retain aging-associated gene signatures, iNs displayed age-specific transcriptional profiles and revealed age-associated decreases in the nuclear transport receptor RanBP17. We detected an age-dependent loss of nucleocytoplasmic compartmentalization (NCC) in donor fibroblasts and corresponding iNs and found that reduced RanBP17 impaired NCC in young cells, while iPSC rejuvenation restored NCC in aged cells. These results show that iNs retain important aging-related signatures, thus allowing modeling of the aging process in vitro, and they identify impaired NCC as an important factor in human aging.","lang":"eng"}],"publication_status":"published","title":"Directly reprogrammed human neurons retain aging-associated transcriptomic signatures and reveal age-related nucleocytoplasmic defects","date_published":"2015-12-03T00:00:00Z","publisher":"Elsevier","pmid":1,"oa":1,"page":"705-718","doi":"10.1016/j.stem.2015.09.001","year":"2015","day":"03","keyword":["Cell Biology","Genetics","Molecular Medicine"],"scopus_import":"1","publication":"Cell Stem Cell","intvolume":" 17"},{"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1504.01734"}],"status":"public","publication_identifier":{"eissn":["1538-4357"],"issn":["0004-637X"]},"date_created":"2022-07-07T09:00:58Z","article_type":"original","type":"journal_article","_id":"11519","author":[{"full_name":"Sobral, David","last_name":"Sobral","first_name":"David"},{"orcid":"0000-0003-2871-127X","first_name":"Jorryt J","last_name":"Matthee","full_name":"Matthee, Jorryt J","id":"7439a258-f3c0-11ec-9501-9df22fe06720"},{"last_name":"Darvish","first_name":"Behnam","full_name":"Darvish, Behnam"},{"first_name":"Daniel","last_name":"Schaerer","full_name":"Schaerer, Daniel"},{"full_name":"Mobasher, Bahram","first_name":"Bahram","last_name":"Mobasher"},{"full_name":"Röttgering, Huub","first_name":"Huub","last_name":"Röttgering"},{"full_name":"Santos, Sérgio","last_name":"Santos","first_name":"Sérgio"},{"full_name":"Hemmati, Shoubaneh","first_name":"Shoubaneh","last_name":"Hemmati"}],"quality_controlled":"1","oa_version":"Preprint","language":[{"iso":"eng"}],"volume":808,"article_processing_charge":"No","month":"07","issue":"2","acknowledgement":"We thank the anonymous reviewer for useful and constructive comments and suggestions which greatly improved the quality and clarity of our work. D.S. acknowledges financial support from the Netherlands Organisation for Scientific research (NWO) through a Veni fellowship, from FCT through a FCT Investigator Starting Grant and Start-up Grant (IF/01154/2012/CP0189/CT0010), from FCT grant UID/FIS/04434/2013, and from LSF and LKBF. J.M. acknowledges the award of a Huygens PhD fellowship. H.R. acknowledges support from the ERC Advanced Investigator program NewClusters 321271. The authors thank Mark Dijkstra, Bhaskar Agarwal, Jarrett Johnson, Andrea Ferrara, Jarle Brinchmann, Rebecca Bowler, George Becker, Emma Curtis-Lake, Milos Milosavljevic, Raffaella Schneider, Paul Shapiro, and Erik Zackrisson for interesting, stimulating and helpful discussions. The authors are extremely grateful to ESO for the award of ESO DDT time (294.A-5018 and 294.A-5039) which allowed the spectroscopic confirmation of both sources and the detailed investigation of their nature. Observations are also based on data from W.M. Keck Observatory. The W.M. Keck Observatory is operated as a scientific partnership of Caltech, the University of California and the National Aeronautics and Space Administration. Based on observations obtained with MegaPrime/Megacam, a joint project of CFHT and CEA/IRFU, at the Canada–France–Hawaii Telescope (CFHT) which is operated by the National Research Council (NRC) of Canada, the Institut National des Science de lUnivers of the Centre National de la Recherche Scientifique (CNRS) of France, and the University of Hawaii. This work is based in part on data products produced at Terapix available at the Canadian Astronomy Data Centre as part of the Canada–France–Hawaii Telescope Legacy Survey, a collaborative project of NRC and CNRS. Based on data products from observations made with ESO Telescopes at the La Silla Paranal Observatory under ESO programme IDs 294.A-5018, 294.A-5039, and 179.A-2005, and on data products produced by TERAPIX and the Cambridge Astronomy Survey Unit on behalf of the UltraVISTA consortium. The authors acknowledge the award of service time (SW2014b20) on the William Herschel Telescope (WHT). WHT and its service programme are operated on the island of La Palma by the Isaac Newton Group in the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofisica de Canarias.","year":"2015","doi":"10.1088/0004-637X/808/2/139","page":"139","day":"28","oa":1,"arxiv":1,"intvolume":" 808","publication":"The Astrophysical Journal","scopus_import":"1","keyword":["Space and Planetary Science","Astronomy and Astrophysics","dark ages","reionization","first stars – early universe – galaxies: evolution"],"external_id":{"arxiv":["1504.01734"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","extern":"1","date_updated":"2022-08-18T10:30:13Z","citation":{"mla":"Sobral, David, et al. “Evidence for PopIII-like Stellar Populations in the Most Luminous Lyα Emitters at the Epoch of Reionisation: Spectroscopic Confirmation.” The Astrophysical Journal, vol. 808, no. 2, IOP Publishing, 2015, p. 139, doi:10.1088/0004-637X/808/2/139.","short":"D. Sobral, J.J. Matthee, B. Darvish, D. Schaerer, B. Mobasher, H. Röttgering, S. Santos, S. Hemmati, The Astrophysical Journal 808 (2015) 139.","apa":"Sobral, D., Matthee, J. J., Darvish, B., Schaerer, D., Mobasher, B., Röttgering, H., … Hemmati, S. (2015). Evidence for PopIII-like stellar populations in the most luminous Lyα emitters at the epoch of reionisation: Spectroscopic confirmation. The Astrophysical Journal. IOP Publishing. https://doi.org/10.1088/0004-637X/808/2/139","ista":"Sobral D, Matthee JJ, Darvish B, Schaerer D, Mobasher B, Röttgering H, Santos S, Hemmati S. 2015. Evidence for PopIII-like stellar populations in the most luminous Lyα emitters at the epoch of reionisation: Spectroscopic confirmation. The Astrophysical Journal. 808(2), 139.","chicago":"Sobral, David, Jorryt J Matthee, Behnam Darvish, Daniel Schaerer, Bahram Mobasher, Huub Röttgering, Sérgio Santos, and Shoubaneh Hemmati. “Evidence for PopIII-like Stellar Populations in the Most Luminous Lyα Emitters at the Epoch of Reionisation: Spectroscopic Confirmation.” The Astrophysical Journal. IOP Publishing, 2015. https://doi.org/10.1088/0004-637X/808/2/139.","ama":"Sobral D, Matthee JJ, Darvish B, et al. Evidence for PopIII-like stellar populations in the most luminous Lyα emitters at the epoch of reionisation: Spectroscopic confirmation. The Astrophysical Journal. 2015;808(2):139. doi:10.1088/0004-637X/808/2/139","ieee":"D. Sobral et al., “Evidence for PopIII-like stellar populations in the most luminous Lyα emitters at the epoch of reionisation: Spectroscopic confirmation,” The Astrophysical Journal, vol. 808, no. 2. IOP Publishing, p. 139, 2015."},"publisher":"IOP Publishing","date_published":"2015-07-28T00:00:00Z","title":"Evidence for PopIII-like stellar populations in the most luminous Lyα emitters at the epoch of reionisation: Spectroscopic confirmation","publication_status":"published","abstract":[{"text":"Faint Lyα emitters become increasingly rarer toward the reionization epoch (z ∼ 6–7). However, observations from a very large (∼5 deg2) Lyα narrow-band survey at z = 6.6 show that this is not the case for the most luminous emitters, capable of ionizing their own local bubbles. Here we present follow-up observations of the two most luminous Lyα candidates in the COSMOS field: “MASOSA” and “CR7.” We used X-SHOOTER, SINFONI, and FORS2 on the Very Large Telescope, and DEIMOS on Keck, to confirm both candidates beyond any doubt. We find redshifts of z = 6.541 and z = 6.604 for “MASOSA” and “CR7,” respectively. MASOSA has a strong detection in Lyα with a line width of 386 ± 30 km s−1 (FWHM) and with very high EW0 (>200 Å), but undetected in the continuum, implying very low stellar mass and a likely young, metal-poor stellar population. “CR7,” with an observed Lyα luminosity of 1043.92±0.05 erg s−1 is the most luminous Lyα emitter ever found at z > 6 and is spatially extended (∼16 kpc). “CR7” reveals a narrow Lyα line with 266 ± 15 km s−1 FWHM, being detected in the near-infrared (NIR) (rest-frame UV; β = −2.3 ± 0.1) and in IRAC/Spitzer. We detect a narrow He II 1640 Å emission line (6σ, FWHM = 130 ± 30 km s−1 ) in CR7 which can explain the clear excess seen in the J-band photometry (EW0 ∼ 80 Å). We find no other emission lines from the UV to the NIR in our X-SHOOTER spectra (He II/O III] 1663 Å > 3 and He II/C III] 1908 Å > 2.5). We conclude that CR7 is best explained by a combination of a PopIII-like population, which dominates the rest-frame UV and the nebular emission, and a more normal stellar population, which presumably dominates the mass. Hubble Space Telescope/WFC3 observations show that the light is indeed spatially separated between a very blue component, coincident with Lyα and He II emission, and two red components (∼5 kpc away), which dominate the mass. Our findings are consistent with theoretical predictions of a PopIII wave, with PopIII star formation migrating away from the original sites of star formation.","lang":"eng"}]},{"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1506.07173"}],"status":"public","publication_identifier":{"issn":["0035-8711"],"eissn":["1365-2966"]},"article_type":"original","type":"journal_article","_id":"11579","date_created":"2022-07-14T08:58:36Z","volume":453,"article_processing_charge":"No","language":[{"iso":"eng"}],"issue":"3","month":"11","author":[{"first_name":"A.","last_name":"Pallottini","full_name":"Pallottini, A."},{"full_name":"Ferrara, A.","first_name":"A.","last_name":"Ferrara"},{"last_name":"Pacucci","first_name":"F.","full_name":"Pacucci, F."},{"last_name":"Gallerani","first_name":"S.","full_name":"Gallerani, S."},{"full_name":"Salvadori, S.","first_name":"S.","last_name":"Salvadori"},{"last_name":"Schneider","first_name":"R.","full_name":"Schneider, R."},{"full_name":"Schaerer, D.","first_name":"D.","last_name":"Schaerer"},{"first_name":"D.","last_name":"Sobral","full_name":"Sobral, D."},{"orcid":"0000-0003-2871-127X","last_name":"Matthee","first_name":"Jorryt J","full_name":"Matthee, Jorryt J","id":"7439a258-f3c0-11ec-9501-9df22fe06720"}],"oa_version":"Preprint","quality_controlled":"1","publication":"Monthly Notices of the Royal Astronomical Society","arxiv":1,"intvolume":" 453","keyword":["Space and Planetary Science","Astronomy and Astrophysics","black hole physics","stars: Population III","galaxies: high-redshift"],"scopus_import":"1","day":"01","year":"2015","doi":"10.1093/mnras/stv1795","page":"2465-2470","acknowledgement":"SS acknowledges support from the Netherlands Organization for Scientific research (NWO), VENI grant 639.041.233. RS acknowledges support from the European Research Council under the European Union (FP/2007-2013)/ERC grant agreement no. 306476. DS acknowledges (i) financial support from the NWO through a Veni fellowship and (ii) funding from FCT through a FCT Investigator Starting Grant and Start-up Grant (IF/01154/2012/CP0189/CT0010) and from FCT grant PEstOE/FIS/UI2751/2014.","oa":1,"title":"The brightest Lyα emitter: Pop III or black hole?","publisher":"Oxford University Press","date_published":"2015-11-01T00:00:00Z","publication_status":"published","abstract":[{"text":"CR7 is the brightest z = 6.6 Ly α emitter (LAE) known to date, and spectroscopic follow-up by Sobral et al. suggests that CR7 might host Population (Pop) III stars. We examine this interpretation using cosmological hydrodynamical simulations. Several simulated galaxies show the same ‘Pop III wave’ pattern observed in CR7. However, to reproduce the extreme CR7 Ly α/He II1640 line luminosities (Lα/HeII) a top-heavy initial mass function and a massive ( ≳ 107 M⊙) Pop III burst with age ≲ 2 Myr are required. Assuming that the observed properties of Ly α and He II emission are typical for Pop III, we predict that in the COSMOS/UDS/SA22 fields, 14 out of the 30 LAEs at z = 6.6 with Lα > 1043.3 erg s−1 should also host Pop III stars producing an observable LHeII≳1042.7ergs−1. As an alternate explanation, we explore the possibility that CR7 is instead powered by accretion on to a direct collapse black hole. Our model predicts Lα, LHeII, and X-ray luminosities that are in agreement with the observations. In any case, the observed properties of CR7 indicate that this galaxy is most likely powered by sources formed from pristine gas. We propose that further X-ray observations can distinguish between the two above scenarios.","lang":"eng"}],"external_id":{"arxiv":["1506.07173"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"mla":"Pallottini, A., et al. “The Brightest Lyα Emitter: Pop III or Black Hole?” Monthly Notices of the Royal Astronomical Society, vol. 453, no. 3, Oxford University Press, 2015, pp. 2465–70, doi:10.1093/mnras/stv1795.","short":"A. Pallottini, A. Ferrara, F. Pacucci, S. Gallerani, S. Salvadori, R. Schneider, D. Schaerer, D. Sobral, J.J. Matthee, Monthly Notices of the Royal Astronomical Society 453 (2015) 2465–2470.","ama":"Pallottini A, Ferrara A, Pacucci F, et al. The brightest Lyα emitter: Pop III or black hole? Monthly Notices of the Royal Astronomical Society. 2015;453(3):2465-2470. doi:10.1093/mnras/stv1795","ista":"Pallottini A, Ferrara A, Pacucci F, Gallerani S, Salvadori S, Schneider R, Schaerer D, Sobral D, Matthee JJ. 2015. The brightest Lyα emitter: Pop III or black hole? Monthly Notices of the Royal Astronomical Society. 453(3), 2465–2470.","chicago":"Pallottini, A., A. Ferrara, F. Pacucci, S. Gallerani, S. Salvadori, R. Schneider, D. Schaerer, D. Sobral, and Jorryt J Matthee. “The Brightest Lyα Emitter: Pop III or Black Hole?” Monthly Notices of the Royal Astronomical Society. Oxford University Press, 2015. https://doi.org/10.1093/mnras/stv1795.","apa":"Pallottini, A., Ferrara, A., Pacucci, F., Gallerani, S., Salvadori, S., Schneider, R., … Matthee, J. J. (2015). The brightest Lyα emitter: Pop III or black hole? Monthly Notices of the Royal Astronomical Society. Oxford University Press. https://doi.org/10.1093/mnras/stv1795","ieee":"A. Pallottini et al., “The brightest Lyα emitter: Pop III or black hole?,” Monthly Notices of the Royal Astronomical Society, vol. 453, no. 3. Oxford University Press, pp. 2465–2470, 2015."},"extern":"1","date_updated":"2022-08-19T08:19:23Z"},{"author":[{"first_name":"D.","last_name":"Sobral","full_name":"Sobral, D."},{"full_name":"Matthee, Jorryt J","id":"7439a258-f3c0-11ec-9501-9df22fe06720","orcid":"0000-0003-2871-127X","first_name":"Jorryt J","last_name":"Matthee"},{"last_name":"Best","first_name":"P. N.","full_name":"Best, P. N."},{"full_name":"Smail, I.","first_name":"I.","last_name":"Smail"},{"last_name":"Khostovan","first_name":"A. A.","full_name":"Khostovan, A. A."},{"full_name":"Milvang-Jensen, B.","first_name":"B.","last_name":"Milvang-Jensen"},{"last_name":"Kim","first_name":"J.-W.","full_name":"Kim, J.-W."},{"full_name":"Stott, J.","last_name":"Stott","first_name":"J."},{"full_name":"Calhau, J.","last_name":"Calhau","first_name":"J."},{"full_name":"Nayyeri, H.","first_name":"H.","last_name":"Nayyeri"},{"first_name":"B.","last_name":"Mobasher","full_name":"Mobasher, B."}],"oa_version":"Preprint","quality_controlled":"1","volume":451,"article_processing_charge":"No","language":[{"iso":"eng"}],"issue":"3","month":"08","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1502.06602"}],"publication_identifier":{"eissn":["1365-2966"],"issn":["0035-8711"]},"status":"public","article_type":"original","_id":"11580","type":"journal_article","date_created":"2022-07-14T09:02:22Z","external_id":{"arxiv":["1502.06602"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"mla":"Sobral, D., et al. “CF-HiZELS, an ∼10 Deg2 Emission-Line Survey with Spectroscopic Follow-up: Hα, [O III] + Hβ and [O II] Luminosity Functions at z = 0.8, 1.4 and 2.2 .” Monthly Notices of the Royal Astronomical Society, vol. 451, no. 3, Oxford University Press, 2015, pp. 2303–23, doi:10.1093/mnras/stv1076.","short":"D. Sobral, J.J. Matthee, P.N. Best, I. Smail, A.A. Khostovan, B. Milvang-Jensen, J.-W. Kim, J. Stott, J. Calhau, H. Nayyeri, B. Mobasher, Monthly Notices of the Royal Astronomical Society 451 (2015) 2303–2323.","ieee":"D. Sobral et al., “CF-HiZELS, an ∼10 deg2 emission-line survey with spectroscopic follow-up: Hα, [O III] + Hβ and [O II] luminosity functions at z = 0.8, 1.4 and 2.2 ,” Monthly Notices of the Royal Astronomical Society, vol. 451, no. 3. Oxford University Press, pp. 2303–2323, 2015.","apa":"Sobral, D., Matthee, J. J., Best, P. N., Smail, I., Khostovan, A. A., Milvang-Jensen, B., … Mobasher, B. (2015). CF-HiZELS, an ∼10 deg2 emission-line survey with spectroscopic follow-up: Hα, [O III] + Hβ and [O II] luminosity functions at z = 0.8, 1.4 and 2.2 . Monthly Notices of the Royal Astronomical Society. Oxford University Press. https://doi.org/10.1093/mnras/stv1076","ama":"Sobral D, Matthee JJ, Best PN, et al. CF-HiZELS, an ∼10 deg2 emission-line survey with spectroscopic follow-up: Hα, [O III] + Hβ and [O II] luminosity functions at z = 0.8, 1.4 and 2.2 . Monthly Notices of the Royal Astronomical Society. 2015;451(3):2303-2323. doi:10.1093/mnras/stv1076","ista":"Sobral D, Matthee JJ, Best PN, Smail I, Khostovan AA, Milvang-Jensen B, Kim J-W, Stott J, Calhau J, Nayyeri H, Mobasher B. 2015. CF-HiZELS, an ∼10 deg2 emission-line survey with spectroscopic follow-up: Hα, [O III] + Hβ and [O II] luminosity functions at z = 0.8, 1.4 and 2.2 . Monthly Notices of the Royal Astronomical Society. 451(3), 2303–2323.","chicago":"Sobral, D., Jorryt J Matthee, P. N. Best, I. Smail, A. A. Khostovan, B. Milvang-Jensen, J.-W. Kim, et al. “CF-HiZELS, an ∼10 Deg2 Emission-Line Survey with Spectroscopic Follow-up: Hα, [O III] + Hβ and [O II] Luminosity Functions at z = 0.8, 1.4 and 2.2 .” Monthly Notices of the Royal Astronomical Society. Oxford University Press, 2015. https://doi.org/10.1093/mnras/stv1076."},"extern":"1","date_updated":"2022-08-19T08:23:18Z","title":"CF-HiZELS, an ∼10 deg2 emission-line survey with spectroscopic follow-up: Hα, [O III] + Hβ and [O II] luminosity functions at z = 0.8, 1.4 and 2.2 ","date_published":"2015-08-11T00:00:00Z","publisher":"Oxford University Press","publication_status":"published","abstract":[{"lang":"eng","text":"We present results from the largest contiguous narrow-band survey in the near-infrared. We have used the wide-field infrared camera/Canada–France–Hawaii Telescope and the lowOH2 filter (1.187 ± 0.005 μm) to survey ≈10 deg2 of contiguous extragalactic sky in the SA22 field. A total of ∼6000 candidate emission-line galaxies are found. We use deep ugrizJK data to obtain robust photometric redshifts. We combine our data with the High-redshift(Z) Emission Line Survey (HiZELS), explore spectroscopic surveys (VVDS, VIPERS) and obtain our own spectroscopic follow-up with KMOS, FMOS and MOSFIRE to derive large samples of high-redshift emission-line selected galaxies: 3471 Hα emitters at z = 0.8, 1343 [O III] + Hβ emitters at z = 1.4 and 572 [O II] emitters at z = 2.2. We probe comoving volumes of >106 Mpc3 and find significant overdensities, including an 8.5σ (spectroscopically confirmed) overdensity of Hα emitters at z = 0.81. We derive Hα, [O III] + Hβ and [O II] luminosity functions at z = 0.8, 1.4, 2.2, respectively, and present implications for future surveys such as Euclid. Our uniquely large volumes/areas allow us to subdivide the samples in thousands of randomized combinations of areas and provide a robust empirical measurement of sample/cosmic variance. We show that surveys for star-forming/emission-line galaxies at a depth similar to ours can only overcome cosmic-variance (errors <10 per cent) if they are based on volumes >5 × 105 Mpc3; errors on L* and ϕ* due to sample (cosmic) variance on surveys probing ∼104 and ∼105 Mpc3 are typically very high: ∼300 and ∼40–60 per cent, respectively."}],"doi":"10.1093/mnras/stv1076","day":"11","page":"2303-2323","year":"2015","acknowledgement":"The authors wish to thank the anonymous reviewer for many helpful comments and suggestions which greatly improved the clarity and quality of this work. DS acknowledges financial support from the Netherlands Organization for Scientific research (NWO) through a Veni fellowship, from FCT through an FCT Investigator Starting Grant and Start-up Grant (IF/01154/2012/CP0189/CT0010), from FCT grant PEst-OE/FIS/UI2751/2014, and from LSF and LKBF. JM acknowledges the award of a Huygens PhD fellowship. PNB is grateful for support from STFC. IRS acknowledges support from STFC, a Leverhulme Fellowship, the ERC Advanced Investigator programme DUSTYGAL and a Royal Society/Wolfson Merit Award. BMJ acknowledges support from the ERC-StG grant EGGS-278202. The Dark Cosmology Centre is funded by the DNRF. The Dark Cosmology Centre is funded by the DNRF. JWK acknowledges support from the National Research Foundation of Korea (NRF) grant, no. 2008-0060544, funded by the Korea government (MSIP). JPS acknowledges support from STFC (ST/I001573/1). JC acknowledges support from the FCT-IF grant IF/01154/2012/CP0189/CT0010. The work was only possible due to OPTICON/FP7 and the invaluable access that it granted to the CFHT telescope. We would also like to acknowledge the excellent work done by CFHT staff in conducting the observations in service mode, and on delivering truly excellent data. We are also tremendously thankful to Kentaro Aoki for the incredible support while observing at Subaru with FMOS, and also to the Keck staff for the help with the observations with MOSFIRE. This work is based on observations obtained with WIRCam on the CFHT, OPTICON programme 2011B/029, 2012A019 and 2012B/016. Based on observations made with ESO telescopes at the La Silla Paranal Observatory under programmes IDs 60.A-9460 (data can be accessed through the ESO data archive), 087.A 0337 and 089.A-0965. Based on observations done with FMOS on Subaru under programme S14A-084, and on MOSFIRE/Keck observations under programme U066M. Part of the data on which this analysis is based are available from Sobral et al. (2013a). Dedicated to the memory of C. M. Sobral (1953-2014).","oa":1,"publication":"Monthly Notices of the Royal Astronomical Society","arxiv":1,"intvolume":" 451","keyword":["Space and Planetary Science","Astronomy and Astrophysics","galaxies: evolution","galaxies: formation","galaxies: luminosity function","mass function","cosmology: observations","early Universe","large-scale structure of Universe"],"scopus_import":"1"}]