[{"extern":"1","oa":1,"intvolume":"        19","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","issue":"1-2","volume":19,"date_created":"2021-01-19T11:11:54Z","_id":"9019","page":"19-27","publication":"Comptes Rendus Chimie","file_date_updated":"2021-01-22T12:36:52Z","article_processing_charge":"No","keyword":["General Chemistry","General Chemical Engineering"],"date_published":"2016-02-06T00:00:00Z","month":"02","date_updated":"2023-02-23T13:46:55Z","title":"Targeting protein–protein interactions, a wide open field for drug design","article_type":"original","ddc":["570"],"type":"journal_article","citation":{"apa":"Bakail, M. M., &#38; Ochsenbein, F. (2016). Targeting protein–protein interactions, a wide open field for drug design. <i>Comptes Rendus Chimie</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.crci.2015.12.004\">https://doi.org/10.1016/j.crci.2015.12.004</a>","short":"M.M. Bakail, F. Ochsenbein, Comptes Rendus Chimie 19 (2016) 19–27.","ieee":"M. M. Bakail and F. Ochsenbein, “Targeting protein–protein interactions, a wide open field for drug design,” <i>Comptes Rendus Chimie</i>, vol. 19, no. 1–2. Elsevier, pp. 19–27, 2016.","chicago":"Bakail, May M, and Francoise Ochsenbein. “Targeting Protein–Protein Interactions, a Wide Open Field for Drug Design.” <i>Comptes Rendus Chimie</i>. Elsevier, 2016. <a href=\"https://doi.org/10.1016/j.crci.2015.12.004\">https://doi.org/10.1016/j.crci.2015.12.004</a>.","ama":"Bakail MM, Ochsenbein F. Targeting protein–protein interactions, a wide open field for drug design. <i>Comptes Rendus Chimie</i>. 2016;19(1-2):19-27. doi:<a href=\"https://doi.org/10.1016/j.crci.2015.12.004\">10.1016/j.crci.2015.12.004</a>","ista":"Bakail MM, Ochsenbein F. 2016. Targeting protein–protein interactions, a wide open field for drug design. Comptes Rendus Chimie. 19(1–2), 19–27.","mla":"Bakail, May M., and Francoise Ochsenbein. “Targeting Protein–Protein Interactions, a Wide Open Field for Drug Design.” <i>Comptes Rendus Chimie</i>, vol. 19, no. 1–2, Elsevier, 2016, pp. 19–27, doi:<a href=\"https://doi.org/10.1016/j.crci.2015.12.004\">10.1016/j.crci.2015.12.004</a>."},"file":[{"date_updated":"2021-01-22T12:36:52Z","content_type":"application/pdf","file_size":2045260,"checksum":"c262814ffdbfe95900256ab9ff42cdf5","relation":"main_file","success":1,"access_level":"open_access","file_name":"2016_ComptesRendueChimie_Bakail.pdf","file_id":"9035","creator":"dernst","date_created":"2021-01-22T12:36:52Z"}],"quality_controlled":"1","has_accepted_license":"1","status":"public","language":[{"iso":"eng"}],"abstract":[{"text":"Targeting protein–protein interactions has long been considered as a very difficult if impossible task, but over the past decade, front lines have moved. The number of successful examples is exponentially growing. This review presents a rapid overview of recent advances in this field considering the strengths and weaknesses of the small molecule approaches and alternative strategies such as the selection or design of artificial antibodies, peptides or peptidomimetics.","lang":"eng"},{"lang":"fre","text":"Cibler les interactions protéine–protéine a longtemps été considéré comme une tâche très difficile, voire impossible, mais, depuis les dix dernières années, les lignes ont bougé. Le nombre d’exemples de réussites s’accroît exponentiellement. Cette revue présente un rapide panorama des avancées récentes dans ce domaine, considérant les forces et les faiblesses de l’approche « petite molécule » ainsi que des stratégies alternatives comme la sélection ou le design d’anticorps artificiels, de peptides ou de peptidomimétiques."}],"publication_status":"published","day":"06","publisher":"Elsevier","oa_version":"Published Version","doi":"10.1016/j.crci.2015.12.004","year":"2016","author":[{"id":"FB3C3F8E-522F-11EA-B186-22963DDC885E","first_name":"May M","last_name":"Bakail","orcid":"0000-0002-9592-1587","full_name":"Bakail, May M"},{"first_name":"Francoise","last_name":"Ochsenbein","full_name":"Ochsenbein, Francoise"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)","image":"/images/cc_by_nc_nd.png"},"publication_identifier":{"issn":["1631-0748"]}},{"volume":12,"main_file_link":[{"url":"https://arxiv.org/abs/1509.06330","open_access":"1"}],"user_id":"D865714E-FA4E-11E9-B85B-F5C5E5697425","issue":"20","oa":1,"intvolume":"        12","scopus_import":"1","extern":"1","date_updated":"2023-02-23T13:47:38Z","title":"Dynamic self-assembly of microscale rotors and swimmers","month":"05","date_published":"2016-05-28T00:00:00Z","article_processing_charge":"No","publication":"Soft Matter","page":"4584-4589","_id":"9051","date_created":"2021-02-01T13:44:00Z","external_id":{"arxiv":["1509.06330"],"pmid":["27121100"]},"publication_status":"published","abstract":[{"lang":"eng","text":"Biological systems often involve the self-assembly of basic components into complex and functioning structures. Artificial systems that mimic such processes can provide a well-controlled setting to explore the principles involved and also synthesize useful micromachines. Our experiments show that immotile, but active, components self-assemble into two types of structure that exhibit the fundamental forms of motility: translation and rotation. Specifically, micron-scale metallic rods are designed to induce extensile surface flows in the presence of a chemical fuel; these rods interact with each other and pair up to form either a swimmer or a rotor. Such pairs can transition reversibly between these two configurations, leading to kinetics reminiscent of bacterial run-and-tumble motion."}],"language":[{"iso":"eng"}],"pmid":1,"status":"public","quality_controlled":"1","type":"journal_article","citation":{"apa":"Davies Wykes, M. S., Palacci, J. A., Adachi, T., Ristroph, L., Zhong, X., Ward, M. D., … Shelley, M. J. (2016). Dynamic self-assembly of microscale rotors and swimmers. <i>Soft Matter</i>. Royal Society of Chemistry. <a href=\"https://doi.org/10.1039/c5sm03127c\">https://doi.org/10.1039/c5sm03127c</a>","short":"M.S. Davies Wykes, J.A. Palacci, T. Adachi, L. Ristroph, X. Zhong, M.D. Ward, J. Zhang, M.J. Shelley, Soft Matter 12 (2016) 4584–4589.","ieee":"M. S. Davies Wykes <i>et al.</i>, “Dynamic self-assembly of microscale rotors and swimmers,” <i>Soft Matter</i>, vol. 12, no. 20. Royal Society of Chemistry, pp. 4584–4589, 2016.","ama":"Davies Wykes MS, Palacci JA, Adachi T, et al. Dynamic self-assembly of microscale rotors and swimmers. <i>Soft Matter</i>. 2016;12(20):4584-4589. doi:<a href=\"https://doi.org/10.1039/c5sm03127c\">10.1039/c5sm03127c</a>","chicago":"Davies Wykes, Megan S., Jérémie A Palacci, Takuji Adachi, Leif Ristroph, Xiao Zhong, Michael D. Ward, Jun Zhang, and Michael J. Shelley. “Dynamic Self-Assembly of Microscale Rotors and Swimmers.” <i>Soft Matter</i>. Royal Society of Chemistry, 2016. <a href=\"https://doi.org/10.1039/c5sm03127c\">https://doi.org/10.1039/c5sm03127c</a>.","ista":"Davies Wykes MS, Palacci JA, Adachi T, Ristroph L, Zhong X, Ward MD, Zhang J, Shelley MJ. 2016. Dynamic self-assembly of microscale rotors and swimmers. Soft Matter. 12(20), 4584–4589.","mla":"Davies Wykes, Megan S., et al. “Dynamic Self-Assembly of Microscale Rotors and Swimmers.” <i>Soft Matter</i>, vol. 12, no. 20, Royal Society of Chemistry, 2016, pp. 4584–89, doi:<a href=\"https://doi.org/10.1039/c5sm03127c\">10.1039/c5sm03127c</a>."},"article_type":"original","publication_identifier":{"issn":["1744-683X"],"eissn":["1744-6848"]},"author":[{"first_name":"Megan S.","full_name":"Davies Wykes, Megan S.","last_name":"Davies Wykes"},{"orcid":"0000-0002-7253-9465","full_name":"Palacci, Jérémie A","last_name":"Palacci","id":"8fb92548-2b22-11eb-b7c1-a3f0d08d7c7d","first_name":"Jérémie A"},{"first_name":"Takuji","last_name":"Adachi","full_name":"Adachi, Takuji"},{"first_name":"Leif","last_name":"Ristroph","full_name":"Ristroph, Leif"},{"first_name":"Xiao","full_name":"Zhong, Xiao","last_name":"Zhong"},{"last_name":"Ward","full_name":"Ward, Michael D.","first_name":"Michael D."},{"first_name":"Jun","full_name":"Zhang, Jun","last_name":"Zhang"},{"first_name":"Michael J.","full_name":"Shelley, Michael J.","last_name":"Shelley"}],"year":"2016","doi":"10.1039/c5sm03127c","arxiv":1,"oa_version":"Preprint","publisher":"Royal Society of Chemistry","day":"28"},{"scopus_import":"1","extern":"1","user_id":"D865714E-FA4E-11E9-B85B-F5C5E5697425","issue":"30","oa":1,"intvolume":"        12","volume":12,"main_file_link":[{"url":"https://arxiv.org/abs/1609.01497","open_access":"1"}],"date_created":"2021-02-01T13:44:15Z","external_id":{"pmid":["27338294"],"arxiv":["1609.01497"]},"_id":"9052","page":"6357-6364","publication":"Soft Matter","date_published":"2016-08-14T00:00:00Z","keyword":["General Chemistry","Condensed Matter Physics"],"article_processing_charge":"No","month":"08","date_updated":"2023-02-23T13:47:40Z","title":"Trochoidal trajectories of self-propelled Janus particles in a diverging laser beam","article_type":"original","citation":{"ama":"Moyses H, Palacci JA, Sacanna S, Grier DG. Trochoidal trajectories of self-propelled Janus particles in a diverging laser beam. <i>Soft Matter</i>. 2016;12(30):6357-6364. doi:<a href=\"https://doi.org/10.1039/c6sm01163b\">10.1039/c6sm01163b</a>","chicago":"Moyses, Henrique, Jérémie A Palacci, Stefano Sacanna, and David G. Grier. “Trochoidal Trajectories of Self-Propelled Janus Particles in a Diverging Laser Beam.” <i>Soft Matter</i>. Royal Society of Chemistry , 2016. <a href=\"https://doi.org/10.1039/c6sm01163b\">https://doi.org/10.1039/c6sm01163b</a>.","ista":"Moyses H, Palacci JA, Sacanna S, Grier DG. 2016. Trochoidal trajectories of self-propelled Janus particles in a diverging laser beam. Soft Matter. 12(30), 6357–6364.","mla":"Moyses, Henrique, et al. “Trochoidal Trajectories of Self-Propelled Janus Particles in a Diverging Laser Beam.” <i>Soft Matter</i>, vol. 12, no. 30, Royal Society of Chemistry , 2016, pp. 6357–64, doi:<a href=\"https://doi.org/10.1039/c6sm01163b\">10.1039/c6sm01163b</a>.","apa":"Moyses, H., Palacci, J. A., Sacanna, S., &#38; Grier, D. G. (2016). Trochoidal trajectories of self-propelled Janus particles in a diverging laser beam. <i>Soft Matter</i>. Royal Society of Chemistry . <a href=\"https://doi.org/10.1039/c6sm01163b\">https://doi.org/10.1039/c6sm01163b</a>","short":"H. Moyses, J.A. Palacci, S. Sacanna, D.G. Grier, Soft Matter 12 (2016) 6357–6364.","ieee":"H. Moyses, J. A. Palacci, S. Sacanna, and D. G. Grier, “Trochoidal trajectories of self-propelled Janus particles in a diverging laser beam,” <i>Soft Matter</i>, vol. 12, no. 30. Royal Society of Chemistry , pp. 6357–6364, 2016."},"type":"journal_article","quality_controlled":"1","language":[{"iso":"eng"}],"status":"public","pmid":1,"abstract":[{"lang":"eng","text":"We describe colloidal Janus particles with metallic and dielectric faces that swim vigorously when illuminated by defocused optical tweezers without consuming any chemical fuel. Rather than wandering randomly, these optically-activated colloidal swimmers circulate back and forth through the beam of light, tracing out sinuous rosette patterns. We propose a model for this mode of light-activated transport that accounts for the observed behavior through a combination of self-thermophoresis and optically-induced torque. In the deterministic limit, this model yields trajectories that resemble rosette curves known as hypotrochoids."}],"publication_status":"published","day":"14","publisher":"Royal Society of Chemistry ","arxiv":1,"oa_version":"Preprint","doi":"10.1039/c6sm01163b","author":[{"last_name":"Moyses","full_name":"Moyses, Henrique","first_name":"Henrique"},{"last_name":"Palacci","orcid":"0000-0002-7253-9465","full_name":"Palacci, Jérémie A","id":"8fb92548-2b22-11eb-b7c1-a3f0d08d7c7d","first_name":"Jérémie A"},{"last_name":"Sacanna","full_name":"Sacanna, Stefano","first_name":"Stefano"},{"full_name":"Grier, David G.","last_name":"Grier","first_name":"David G."}],"year":"2016","publication_identifier":{"issn":["1744-683X"],"eissn":["1744-6848"]}},{"type":"journal_article","citation":{"ieee":"P. Drobinski, B. Alonzo, S. Bastin, N. D. Silva, and C. J. Muller, “Scaling of precipitation extremes with temperature in the French Mediterranean region: What explains the hook shape?,” <i>Journal of Geophysical Research: Atmospheres</i>, vol. 121, no. 7. American Geophysical Union, pp. 3100–3119, 2016.","apa":"Drobinski, P., Alonzo, B., Bastin, S., Silva, N. D., &#38; Muller, C. J. (2016). Scaling of precipitation extremes with temperature in the French Mediterranean region: What explains the hook shape? <i>Journal of Geophysical Research: Atmospheres</i>. American Geophysical Union. <a href=\"https://doi.org/10.1002/2015jd023497\">https://doi.org/10.1002/2015jd023497</a>","short":"P. Drobinski, B. Alonzo, S. Bastin, N.D. Silva, C.J. Muller, Journal of Geophysical Research: Atmospheres 121 (2016) 3100–3119.","ista":"Drobinski P, Alonzo B, Bastin S, Silva ND, Muller CJ. 2016. Scaling of precipitation extremes with temperature in the French Mediterranean region: What explains the hook shape? Journal of Geophysical Research: Atmospheres. 121(7), 3100–3119.","mla":"Drobinski, P., et al. “Scaling of Precipitation Extremes with Temperature in the French Mediterranean Region: What Explains the Hook Shape?” <i>Journal of Geophysical Research: Atmospheres</i>, vol. 121, no. 7, American Geophysical Union, 2016, pp. 3100–19, doi:<a href=\"https://doi.org/10.1002/2015jd023497\">10.1002/2015jd023497</a>.","chicago":"Drobinski, P., B. Alonzo, S. Bastin, N. Da Silva, and Caroline J Muller. “Scaling of Precipitation Extremes with Temperature in the French Mediterranean Region: What Explains the Hook Shape?” <i>Journal of Geophysical Research: Atmospheres</i>. American Geophysical Union, 2016. <a href=\"https://doi.org/10.1002/2015jd023497\">https://doi.org/10.1002/2015jd023497</a>.","ama":"Drobinski P, Alonzo B, Bastin S, Silva ND, Muller CJ. Scaling of precipitation extremes with temperature in the French Mediterranean region: What explains the hook shape? <i>Journal of Geophysical Research: Atmospheres</i>. 2016;121(7):3100-3119. doi:<a href=\"https://doi.org/10.1002/2015jd023497\">10.1002/2015jd023497</a>"},"article_type":"original","language":[{"iso":"eng"}],"status":"public","abstract":[{"lang":"eng","text":"Expected changes to future extreme precipitation remain a key uncertainty associated with anthropogenic climate change. Extreme precipitation has been proposed to scale with the precipitable water content in the atmosphere. Assuming constant relative humidity, this implies an increase of precipitation extremes at a rate of about 7% °C−1 globally as indicated by the Clausius‐Clapeyron relationship. Increases faster and slower than Clausius‐Clapeyron have also been reported. In this work, we examine the scaling between precipitation extremes and temperature in the present climate using simulations and measurements from surface weather stations collected in the frame of the HyMeX and MED‐CORDEX programs in Southern France. Of particular interest are departures from the Clausius‐Clapeyron thermodynamic expectation, their spatial and temporal distribution, and their origin. Looking at the scaling of precipitation extreme with temperature, two regimes emerge which form a hook shape: one at low temperatures (cooler than around 15°C) with rates of increase close to the Clausius‐Clapeyron rate and one at high temperatures (warmer than about 15°C) with sub‐Clausius‐Clapeyron rates and most often negative rates. On average, the region of focus does not seem to exhibit super Clausius‐Clapeyron behavior except at some stations, in contrast to earlier studies. Many factors can contribute to departure from Clausius‐Clapeyron scaling: time and spatial averaging, choice of scaling temperature (surface versus condensation level), and precipitation efficiency and vertical velocity in updrafts that are not necessarily constant with temperature. But most importantly, the dynamical contribution of orography to precipitation in the fall over this area during the so‐called “Cevenoles” events, explains the hook shape of the scaling of precipitation extremes."}],"publication_status":"published","quality_controlled":"1","oa_version":"Published Version","doi":"10.1002/2015jd023497","day":"16","publisher":"American Geophysical Union","publication_identifier":{"issn":["2169-897X","2169-8996"]},"author":[{"full_name":"Drobinski, P.","last_name":"Drobinski","first_name":"P."},{"first_name":"B.","last_name":"Alonzo","full_name":"Alonzo, B."},{"full_name":"Bastin, S.","last_name":"Bastin","first_name":"S."},{"full_name":"Silva, N. Da","last_name":"Silva","first_name":"N. Da"},{"full_name":"Muller, Caroline J","orcid":"0000-0001-5836-5350","last_name":"Muller","first_name":"Caroline J","id":"f978ccb0-3f7f-11eb-b193-b0e2bd13182b"}],"year":"2016","extern":"1","volume":121,"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1002/2015JD023497"}],"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","issue":"7","oa":1,"intvolume":"       121","page":"3100-3119","publication":"Journal of Geophysical Research: Atmospheres","date_created":"2021-02-15T14:21:16Z","_id":"9140","month":"03","title":"Scaling of precipitation extremes with temperature in the French Mediterranean region: What explains the hook shape?","date_updated":"2022-01-24T13:41:02Z","date_published":"2016-03-16T00:00:00Z","article_processing_charge":"No"},{"intvolume":"       120","issue":"51","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","acknowledgement":"J.M.C. thanks the 1851 Royal Commission of the Great Exhibition for a Design Fellowship, hosted by Argonne National Laboratory where work done was supported by the DOE Office of Science, Office of Basic Energy Sciences, under Contract No. DE-AC02-06CH11357. T.-C.L acknowledges the Taiwanese Government for a Studying Abroad Scholarship. C.M.A is indebted to the EPSRC UK for a DTA Ph.D. studentship (Grants EP/J500380/1 and EP/L504920/1). Y.T. is grateful for a Cavendish-NUDT Scholarship. The Swiss-Norwegian Collaborative Research Group at the ESRF, Grenoble, France, is thanked for access to synchrotron facilities. The OPAL reactor, ANSTO, Australia, is acknowledged for access to neutron scattering facilities via a program proposal, ID 1236. J.P-M. is grateful to Skidmore College for supporting this work via a full-year sabbatical with enhancement. All authors thank the EPSRC UK National Service for Computational Chemistry Software (NSCCS) and acknowledge contributions from its staff in supporting this work.","quality_controlled":"1","status":"public","language":[{"iso":"eng"}],"publist_id":"7962","abstract":[{"lang":"eng","text":"Advanced organic nonlinear optical (NLO) materials have attracted increasing attention due to their multitude of applications in modern telecommunication devices. Arguably the most important advantage of organic NLO materials, relative to traditionally used inorganic NLO materials, is their short optical response time. Geminal amido esters with their donor-π-acceptor (D-π-A) architecture exhibit high levels of electron delocalization and substantial intramolecular charge transfer, which should endow these materials with short optical response times and large molecular (hyper)polarizabilities. In order to test this hypothesis, the linear and second-order nonlinear optical properties of five geminal amido esters, (E)-ethyl 3-(X-phenylamino)-2-(Y-phenylcarbamoyl)acrylate (1, X = 4-H, Y = 4-H; 2, X = 4-CH3, Y = 4-CH3; 3, X = 4-NO2, Y = 2,5-OCH3; 4, X = 2-Cl, Y = 2-Cl; 5, X = 4-Cl, Y = 4-Cl) were synthesized and characterized, whereby NLO structure-function relationships were established including intramolecular charge transfer characteristics, crystal field effects, and molecular first hyperpolarizabilities (β). Given the typically large errors (10-30%) associated with the determination of β coefficients, three independent methods were used: (i) density functional theory, (ii) hyper-Rayleigh scattering, and (iii) high-resolution X-ray diffraction data analysis based on multipolar modeling of electron densities at each atom. These three methods delivered consistent values of β, and based on these results, 3 should hold the most promise for NLO applications. The correlation between the molecular structure of these geminal amido esters and their linear and nonlinear optical properties thus provide molecular design guidelines for organic NLO materials; this leads to the ultimate goal of generating bespoke organic molecules to suit a given NLO device application."}],"publication_status":"published","volume":120,"extern":"1","type":"journal_article","citation":{"chicago":"Cole, Jaqueline, Tzechia Lin, Christopher Ashcroft, Javier Pérez Moreno, Yizhou Tan, Perumal Venkatesan, Andrew P Higginbotham, et al. “Relating the Structure of Geminal Amido Esters to Their Molecular Hyperpolarizability.” <i>Journal of Physical Chemistry C</i>. American Chemical Society, 2016. <a href=\"https://doi.org/10.1021/acs.jpcc.6b10724\">https://doi.org/10.1021/acs.jpcc.6b10724</a>.","ama":"Cole J, Lin T, Ashcroft C, et al. Relating the structure of geminal Amido Esters to their molecular hyperpolarizability. <i>Journal of Physical Chemistry C</i>. 2016;120(51):29439-29448. doi:<a href=\"https://doi.org/10.1021/acs.jpcc.6b10724\">10.1021/acs.jpcc.6b10724</a>","ista":"Cole J, Lin T, Ashcroft C, Pérez Moreno J, Tan Y, Venkatesan P, Higginbotham AP, Pattison P, Edwards A, Piltz R, Clays K, Ilangovan A. 2016. Relating the structure of geminal Amido Esters to their molecular hyperpolarizability. Journal of Physical Chemistry C. 120(51), 29439–29448.","mla":"Cole, Jaqueline, et al. “Relating the Structure of Geminal Amido Esters to Their Molecular Hyperpolarizability.” <i>Journal of Physical Chemistry C</i>, vol. 120, no. 51, American Chemical Society, 2016, pp. 29439–48, doi:<a href=\"https://doi.org/10.1021/acs.jpcc.6b10724\">10.1021/acs.jpcc.6b10724</a>.","apa":"Cole, J., Lin, T., Ashcroft, C., Pérez Moreno, J., Tan, Y., Venkatesan, P., … Ilangovan, A. (2016). Relating the structure of geminal Amido Esters to their molecular hyperpolarizability. <i>Journal of Physical Chemistry C</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acs.jpcc.6b10724\">https://doi.org/10.1021/acs.jpcc.6b10724</a>","short":"J. Cole, T. Lin, C. Ashcroft, J. Pérez Moreno, Y. Tan, P. Venkatesan, A.P. Higginbotham, P. Pattison, A. Edwards, R. Piltz, K. Clays, A. Ilangovan, Journal of Physical Chemistry C 120 (2016) 29439–29448.","ieee":"J. Cole <i>et al.</i>, “Relating the structure of geminal Amido Esters to their molecular hyperpolarizability,” <i>Journal of Physical Chemistry C</i>, vol. 120, no. 51. American Chemical Society, pp. 29439–29448, 2016."},"year":"2016","author":[{"first_name":"Jaqueline","full_name":"Cole, Jaqueline","last_name":"Cole"},{"first_name":"Tzechia","last_name":"Lin","full_name":"Lin, Tzechia"},{"first_name":"Christopher","last_name":"Ashcroft","full_name":"Ashcroft, Christopher"},{"last_name":"Pérez Moreno","full_name":"Pérez Moreno, Javier","first_name":"Javier"},{"full_name":"Tan, Yizhou","last_name":"Tan","first_name":"Yizhou"},{"first_name":"Perumal","last_name":"Venkatesan","full_name":"Venkatesan, Perumal"},{"first_name":"Andrew P","id":"4AD6785A-F248-11E8-B48F-1D18A9856A87","last_name":"Higginbotham","full_name":"Higginbotham, Andrew P","orcid":"0000-0003-2607-2363"},{"first_name":"Philip","full_name":"Pattison, Philip","last_name":"Pattison"},{"full_name":"Edwards, Alison","last_name":"Edwards","first_name":"Alison"},{"first_name":"Ross","last_name":"Piltz","full_name":"Piltz, Ross"},{"last_name":"Clays","full_name":"Clays, Koen","first_name":"Koen"},{"full_name":"Ilangovan, Andivelu","last_name":"Ilangovan","first_name":"Andivelu"}],"date_published":"2016-12-05T00:00:00Z","month":"12","title":"Relating the structure of geminal Amido Esters to their molecular hyperpolarizability","date_updated":"2021-01-12T08:21:55Z","day":"05","date_created":"2018-12-11T11:44:35Z","_id":"92","publisher":"American Chemical Society","page":"29439 - 29448","oa_version":"None","doi":"10.1021/acs.jpcc.6b10724","publication":"Journal of Physical Chemistry C"},{"title":"Defining the clonal dynamics leading to mouse skin tumour initiation","date_updated":"2021-01-12T08:21:59Z","month":"07","article_processing_charge":"No","year":"2016","author":[{"first_name":"Adriana","full_name":"Sánchez Danés, Adriana","last_name":"Sánchez Danés"},{"last_name":"Hannezo","orcid":"0000-0001-6005-1561","full_name":"Hannezo, Edouard B","first_name":"Edouard B","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Jean","last_name":"Larsimont","full_name":"Larsimont, Jean"},{"first_name":"Mélanie","last_name":"Liagre","full_name":"Liagre, Mélanie"},{"last_name":"Youssef","full_name":"Youssef, Khalil","first_name":"Khalil"},{"full_name":"Simons, Benjamin","last_name":"Simons","first_name":"Benjamin"},{"first_name":"Cédric","last_name":"Blanpain","full_name":"Blanpain, Cédric"}],"date_published":"2016-07-08T00:00:00Z","doi":"10.1038/nature19069","publication":"Nature","page":"298 - 303","oa_version":"None","publisher":"Nature Publishing Group","_id":"930","day":"08","date_created":"2018-12-11T11:49:15Z","publist_id":"6508","volume":536,"abstract":[{"lang":"eng","text":"The changes in cell dynamics after oncogenic mutation that lead to the development of tumours are currently unknown. Here, using skin epidermis as a model, we assessed the effect of oncogenic hedgehog signalling in distinct cell populations and their capacity to induce basal cell carcinoma, the most frequent cancer in humans. We found that only stem cells, and not progenitors, initiated tumour formation upon oncogenic hedgehog signalling. This difference was due to the hierarchical organization of tumour growth in oncogene-targeted stem cells, characterized by an increase in symmetric self-renewing divisions and a higher p53-dependent resistance to apoptosis, leading to rapid clonal expansion and progression into invasive tumours. Our work reveals that the capacity of oncogene-targeted cells to induce tumour formation is dependent not only on their long-term survival and expansion, but also on the specific clonal dynamics of the cancer cell of origin."}],"publication_status":"published","status":"public","language":[{"iso":"eng"}],"intvolume":"       536","acknowledgement":"We would like to thank J.-M. Vanderwinden and the LiMiF for the help with confocal microscopy. C.B. is an investigator of WELBIO. A.S.-D. and J.C.L. are supported by a fellowship of the FNRS and FRIA respectively. B.D.S. and E.H. are supported by the Wellcome Trust (grant numbers 098357/Z/12/Z and 110326/Z/15/Z). E.H. is supported by a fellowship from Trinity College, Cambridge. This work was supported by the FNRS, the IUAP program, the Fondation contre le Cancer, the ULB fondation, the foundation Bettencourt Schueller, the foundation Baillet Latour, a consolidator grant of the European Research Council.","issue":"7616","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","extern":"1","citation":{"ieee":"A. Sánchez Danés <i>et al.</i>, “Defining the clonal dynamics leading to mouse skin tumour initiation,” <i>Nature</i>, vol. 536, no. 7616. Nature Publishing Group, pp. 298–303, 2016.","apa":"Sánchez Danés, A., Hannezo, E. B., Larsimont, J., Liagre, M., Youssef, K., Simons, B., &#38; Blanpain, C. (2016). Defining the clonal dynamics leading to mouse skin tumour initiation. <i>Nature</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/nature19069\">https://doi.org/10.1038/nature19069</a>","short":"A. Sánchez Danés, E.B. Hannezo, J. Larsimont, M. Liagre, K. Youssef, B. Simons, C. Blanpain, Nature 536 (2016) 298–303.","mla":"Sánchez Danés, Adriana, et al. “Defining the Clonal Dynamics Leading to Mouse Skin Tumour Initiation.” <i>Nature</i>, vol. 536, no. 7616, Nature Publishing Group, 2016, pp. 298–303, doi:<a href=\"https://doi.org/10.1038/nature19069\">10.1038/nature19069</a>.","ista":"Sánchez Danés A, Hannezo EB, Larsimont J, Liagre M, Youssef K, Simons B, Blanpain C. 2016. Defining the clonal dynamics leading to mouse skin tumour initiation. Nature. 536(7616), 298–303.","chicago":"Sánchez Danés, Adriana, Edouard B Hannezo, Jean Larsimont, Mélanie Liagre, Khalil Youssef, Benjamin Simons, and Cédric Blanpain. “Defining the Clonal Dynamics Leading to Mouse Skin Tumour Initiation.” <i>Nature</i>. Nature Publishing Group, 2016. <a href=\"https://doi.org/10.1038/nature19069\">https://doi.org/10.1038/nature19069</a>.","ama":"Sánchez Danés A, Hannezo EB, Larsimont J, et al. Defining the clonal dynamics leading to mouse skin tumour initiation. <i>Nature</i>. 2016;536(7616):298-303. doi:<a href=\"https://doi.org/10.1038/nature19069\">10.1038/nature19069</a>"},"type":"journal_article"},{"intvolume":"        93","acknowledgement":"The authors thank Jacques Prost and Pierre Recho for helpful discussions, as well as the Labex CelTisPhyBio and all its members. E.H. acknowledges for funding a Young Researcher Prize from the Bettencourt-Schueller Fondation, and a Junior Research Fellowship from Trinity College, Cambridge.","issue":"2","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publist_id":"6509","abstract":[{"lang":"eng","text":"In many adult tissues, stem cells and differentiated cells are not homogeneously distributed: stem cells are arranged in periodic &quot;niches,&quot; and differentiated cells are constantly produced and migrate out of these niches. In this article, we provide a general theoretical framework to study mixtures of dividing and actively migrating particles, which we apply to biological tissues. We show in particular that the interplay between the stresses arising from active cell migration and stem cell division give rise to robust stem cell patterns. The instability of the tissue leads to spatial patterns which are either steady or oscillating in time. The wavelength of the instability has an order of magnitude consistent with the biological observations. We also discuss the implications of these results for future in vitro and in vivo experiments."}],"publication_status":"published","volume":93,"status":"public","language":[{"iso":"eng"}],"extern":"1","citation":{"apa":"Hannezo, E. B., Coucke, A., &#38; Joanny, J. (2016). Interplay of migratory and division forces as a generic mechanism for stem cell patterns. <i>Physical Review E Statistical Nonlinear and Soft Matter Physics</i>. American Institute of Physics. <a href=\"https://doi.org/10.1103/PhysRevE.93.022405\">https://doi.org/10.1103/PhysRevE.93.022405</a>","short":"E.B. Hannezo, A. Coucke, J. Joanny, Physical Review E Statistical Nonlinear and Soft Matter Physics 93 (2016).","ieee":"E. B. Hannezo, A. Coucke, and J. Joanny, “Interplay of migratory and division forces as a generic mechanism for stem cell patterns,” <i>Physical Review E Statistical Nonlinear and Soft Matter Physics</i>, vol. 93, no. 2. American Institute of Physics, 2016.","chicago":"Hannezo, Edouard B, Alice Coucke, and Jean Joanny. “Interplay of Migratory and Division Forces as a Generic Mechanism for Stem Cell Patterns.” <i>Physical Review E Statistical Nonlinear and Soft Matter Physics</i>. American Institute of Physics, 2016. <a href=\"https://doi.org/10.1103/PhysRevE.93.022405\">https://doi.org/10.1103/PhysRevE.93.022405</a>.","ama":"Hannezo EB, Coucke A, Joanny J. Interplay of migratory and division forces as a generic mechanism for stem cell patterns. <i>Physical Review E Statistical Nonlinear and Soft Matter Physics</i>. 2016;93(2). doi:<a href=\"https://doi.org/10.1103/PhysRevE.93.022405\">10.1103/PhysRevE.93.022405</a>","ista":"Hannezo EB, Coucke A, Joanny J. 2016. Interplay of migratory and division forces as a generic mechanism for stem cell patterns. Physical Review E Statistical Nonlinear and Soft Matter Physics. 93(2).","mla":"Hannezo, Edouard B., et al. “Interplay of Migratory and Division Forces as a Generic Mechanism for Stem Cell Patterns.” <i>Physical Review E Statistical Nonlinear and Soft Matter Physics</i>, vol. 93, no. 2, American Institute of Physics, 2016, doi:<a href=\"https://doi.org/10.1103/PhysRevE.93.022405\">10.1103/PhysRevE.93.022405</a>."},"type":"journal_article","year":"2016","article_processing_charge":"No","date_published":"2016-02-28T00:00:00Z","author":[{"first_name":"Edouard B","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","full_name":"Hannezo, Edouard B","orcid":"0000-0001-6005-1561","last_name":"Hannezo"},{"first_name":"Alice","full_name":"Coucke, Alice","last_name":"Coucke"},{"last_name":"Joanny","full_name":"Joanny, Jean","first_name":"Jean"}],"date_updated":"2021-01-12T08:22:00Z","title":"Interplay of migratory and division forces as a generic mechanism for stem cell patterns","month":"02","publisher":"American Institute of Physics","_id":"931","day":"28","date_created":"2018-12-11T11:49:16Z","doi":"10.1103/PhysRevE.93.022405","publication":"Physical Review E Statistical Nonlinear and Soft Matter Physics","oa_version":"None"},{"extern":"1","citation":{"short":"J. Sedzinski, E.B. Hannezo, F. Tu, M. Biro, J. Wallingford, Developmental Cell 36 (2016) 24–35.","apa":"Sedzinski, J., Hannezo, E. B., Tu, F., Biro, M., &#38; Wallingford, J. (2016). Emergence of an Apical Epithelial Cell Surface In Vivo. <i>Developmental Cell</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.devcel.2015.12.013\">https://doi.org/10.1016/j.devcel.2015.12.013</a>","ieee":"J. Sedzinski, E. B. Hannezo, F. Tu, M. Biro, and J. Wallingford, “Emergence of an Apical Epithelial Cell Surface In Vivo,” <i>Developmental Cell</i>, vol. 36, no. 1. Cell Press, pp. 24–35, 2016.","ama":"Sedzinski J, Hannezo EB, Tu F, Biro M, Wallingford J. Emergence of an Apical Epithelial Cell Surface In Vivo. <i>Developmental Cell</i>. 2016;36(1):24-35. doi:<a href=\"https://doi.org/10.1016/j.devcel.2015.12.013\">10.1016/j.devcel.2015.12.013</a>","chicago":"Sedzinski, Jakub, Edouard B Hannezo, Fan Tu, Maté Biro, and John Wallingford. “Emergence of an Apical Epithelial Cell Surface In Vivo.” <i>Developmental Cell</i>. Cell Press, 2016. <a href=\"https://doi.org/10.1016/j.devcel.2015.12.013\">https://doi.org/10.1016/j.devcel.2015.12.013</a>.","ista":"Sedzinski J, Hannezo EB, Tu F, Biro M, Wallingford J. 2016. Emergence of an Apical Epithelial Cell Surface In Vivo. Developmental Cell. 36(1), 24–35.","mla":"Sedzinski, Jakub, et al. “Emergence of an Apical Epithelial Cell Surface In Vivo.” <i>Developmental Cell</i>, vol. 36, no. 1, Cell Press, 2016, pp. 24–35, doi:<a href=\"https://doi.org/10.1016/j.devcel.2015.12.013\">10.1016/j.devcel.2015.12.013</a>."},"type":"journal_article","publist_id":"6510","volume":36,"publication_status":"published","abstract":[{"lang":"eng","text":"Epithelial sheets are crucial components of all metazoan animals, enclosing organs and protecting the animal from its environment. Epithelial homeostasis poses unique challenges, as addition of new cells and loss of old cells must be achieved without disrupting the fluid-tight barrier and apicobasal polarity of the epithelium. Several studies have identified cell biological mechanisms underlying extrusion of cells from epithelia, but far less is known of the converse mechanism by which new cells are added. Here, we combine molecular, pharmacological, and laser-dissection experiments with theoretical modeling to characterize forces driving emergence of an apical surface as single nascent cells are added to a vertebrate epithelium in vivo. We find that this process involves the interplay between cell-autonomous actin-generated pushing forces in the emerging cell and mechanical properties of neighboring cells. Our findings define the forces driving this cell behavior, contributing to a more comprehensive understanding of epithelial homeostasis."}],"status":"public","language":[{"iso":"eng"}],"intvolume":"        36","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","acknowledgement":"We thank J. Bear, B. Goldstein, A. Ewald, and D. Soroldoni for critical reading. This work was funded by an EMBO Long Term Fellowship to J.S., a Research Fellowship from Trinity College, Cambridge and a Bettencourt-Schueller Foundation Young Researcher Prize to E.H., a Cancer Institute NSW Early Career Researcher fellowship (13/ECF/1–25) and a Cancer Australia/Cure Cancer Australia Foundation project grant (1070498) to M.B., and grants from the NHLBI (HL117164) and NIGMS (GM074104) to J.B.W. J.B.W. was an early career scientist of the Howard Hughes Medical Institute. This work was initiated at the New Quantitative Approaches to Morphogenesis Workshop at UCSB, which is funded in part by the National Science Foundation (PHY11-25915) and the NIGMS (GM067110-05).","issue":"1","publication":"Developmental Cell","doi":"10.1016/j.devcel.2015.12.013","page":"24 - 35","oa_version":"None","publisher":"Cell Press","_id":"932","day":"12","date_created":"2018-12-11T11:49:16Z","date_updated":"2021-01-12T08:22:00Z","title":"Emergence of an Apical Epithelial Cell Surface In Vivo","month":"01","year":"2016","article_processing_charge":"No","author":[{"last_name":"Sedzinski","full_name":"Sedzinski, Jakub","first_name":"Jakub"},{"id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","first_name":"Edouard B","full_name":"Hannezo, Edouard B","orcid":"0000-0001-6005-1561","last_name":"Hannezo"},{"last_name":"Tu","full_name":"Tu, Fan","first_name":"Fan"},{"first_name":"Maté","full_name":"Biro, Maté","last_name":"Biro"},{"first_name":"John","last_name":"Wallingford","full_name":"Wallingford, John"}],"date_published":"2016-01-12T00:00:00Z"},{"extern":"1","article_number":"12492","oa":1,"intvolume":"         7","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","volume":7,"_id":"7068","date_created":"2019-11-19T13:20:53Z","publication":"Nature Communications","file_date_updated":"2020-07-14T12:47:48Z","article_processing_charge":"No","date_published":"2016-08-22T00:00:00Z","title":"Magnetic torque anomaly in the quantum limit of Weyl semimetals","date_updated":"2021-01-12T08:11:40Z","month":"08","ddc":["530"],"article_type":"original","file":[{"file_name":"2016_NatureComm_Moll.pdf","access_level":"open_access","relation":"main_file","checksum":"e3272ed18d22187406b30be48a56e7b2","file_size":663911,"date_updated":"2020-07-14T12:47:48Z","content_type":"application/pdf","creator":"dernst","date_created":"2019-11-26T12:52:19Z","file_id":"7114"}],"citation":{"short":"P.J.W. Moll, A.C. Potter, N.L. Nair, B.J. Ramshaw, K.A. Modic, S. Riggs, B. Zeng, N.J. Ghimire, E.D. Bauer, R. Kealhofer, F. Ronning, J.G. Analytis, Nature Communications 7 (2016).","apa":"Moll, P. J. W., Potter, A. C., Nair, N. L., Ramshaw, B. J., Modic, K. A., Riggs, S., … Analytis, J. G. (2016). Magnetic torque anomaly in the quantum limit of Weyl semimetals. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/ncomms12492\">https://doi.org/10.1038/ncomms12492</a>","ieee":"P. J. W. Moll <i>et al.</i>, “Magnetic torque anomaly in the quantum limit of Weyl semimetals,” <i>Nature Communications</i>, vol. 7. Springer Nature, 2016.","ama":"Moll PJW, Potter AC, Nair NL, et al. Magnetic torque anomaly in the quantum limit of Weyl semimetals. <i>Nature Communications</i>. 2016;7. doi:<a href=\"https://doi.org/10.1038/ncomms12492\">10.1038/ncomms12492</a>","chicago":"Moll, Philip J. W., Andrew C. Potter, Nityan L. Nair, B. J. Ramshaw, Kimberly A Modic, Scott Riggs, Bin Zeng, et al. “Magnetic Torque Anomaly in the Quantum Limit of Weyl Semimetals.” <i>Nature Communications</i>. Springer Nature, 2016. <a href=\"https://doi.org/10.1038/ncomms12492\">https://doi.org/10.1038/ncomms12492</a>.","mla":"Moll, Philip J. W., et al. “Magnetic Torque Anomaly in the Quantum Limit of Weyl Semimetals.” <i>Nature Communications</i>, vol. 7, 12492, Springer Nature, 2016, doi:<a href=\"https://doi.org/10.1038/ncomms12492\">10.1038/ncomms12492</a>.","ista":"Moll PJW, Potter AC, Nair NL, Ramshaw BJ, Modic KA, Riggs S, Zeng B, Ghimire NJ, Bauer ED, Kealhofer R, Ronning F, Analytis JG. 2016. Magnetic torque anomaly in the quantum limit of Weyl semimetals. Nature Communications. 7, 12492."},"type":"journal_article","quality_controlled":"1","publication_status":"published","abstract":[{"lang":"eng","text":"Electrons in materials with linear dispersion behave as massless Weyl- or Dirac-quasiparticles, and continue to intrigue due to their close resemblance to elusive ultra-relativistic particles as well as their potential for future electronics. Yet the experimental signatures of Weyl-fermions are often subtle and indirect, in particular if they coexist with conventional, massive quasiparticles. Here we show a pronounced anomaly in the magnetic torque of the Weyl semimetal NbAs upon entering the quantum limit state in high magnetic fields. The torque changes sign in the quantum limit, signalling a reversal of the magnetic anisotropy that can be directly attributed to the topological nature of the Weyl electrons. Our results establish that anomalous quantum limit torque measurements provide a direct experimental method to identify and distinguish Weyl and Dirac systems."}],"status":"public","has_accepted_license":"1","language":[{"iso":"eng"}],"publisher":"Springer Nature","day":"22","doi":"10.1038/ncomms12492","oa_version":"Published Version","year":"2016","author":[{"first_name":"Philip J. W.","full_name":"Moll, Philip J. W.","last_name":"Moll"},{"full_name":"Potter, Andrew C.","last_name":"Potter","first_name":"Andrew C."},{"full_name":"Nair, Nityan L.","last_name":"Nair","first_name":"Nityan L."},{"first_name":"B. J.","full_name":"Ramshaw, B. J.","last_name":"Ramshaw"},{"first_name":"Kimberly A","id":"13C26AC0-EB69-11E9-87C6-5F3BE6697425","orcid":"0000-0001-9760-3147","full_name":"Modic, Kimberly A","last_name":"Modic"},{"first_name":"Scott","full_name":"Riggs, Scott","last_name":"Riggs"},{"first_name":"Bin","last_name":"Zeng","full_name":"Zeng, Bin"},{"full_name":"Ghimire, Nirmal J.","last_name":"Ghimire","first_name":"Nirmal J."},{"first_name":"Eric D.","last_name":"Bauer","full_name":"Bauer, Eric D."},{"first_name":"Robert","full_name":"Kealhofer, Robert","last_name":"Kealhofer"},{"first_name":"Filip","last_name":"Ronning","full_name":"Ronning, Filip"},{"first_name":"James G.","last_name":"Analytis","full_name":"Analytis, James G."}],"publication_identifier":{"issn":["2041-1723"]},"tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"}},{"type":"journal_article","citation":{"ieee":"M. K. Chan <i>et al.</i>, “Single reconstructed Fermi surface pocket in an underdoped single-layer cuprate superconductor,” <i>Nature Communications</i>, vol. 7. Springer Nature, 2016.","apa":"Chan, M. K., Harrison, N., McDonald, R. D., Ramshaw, B. J., Modic, K. A., Barišić, N., &#38; Greven, M. (2016). Single reconstructed Fermi surface pocket in an underdoped single-layer cuprate superconductor. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/ncomms12244\">https://doi.org/10.1038/ncomms12244</a>","short":"M.K. Chan, N. Harrison, R.D. McDonald, B.J. Ramshaw, K.A. Modic, N. Barišić, M. Greven, Nature Communications 7 (2016).","mla":"Chan, M. K., et al. “Single Reconstructed Fermi Surface Pocket in an Underdoped Single-Layer Cuprate Superconductor.” <i>Nature Communications</i>, vol. 7, 12244, Springer Nature, 2016, doi:<a href=\"https://doi.org/10.1038/ncomms12244\">10.1038/ncomms12244</a>.","ista":"Chan MK, Harrison N, McDonald RD, Ramshaw BJ, Modic KA, Barišić N, Greven M. 2016. Single reconstructed Fermi surface pocket in an underdoped single-layer cuprate superconductor. Nature Communications. 7, 12244.","chicago":"Chan, M. K., N. Harrison, R. D. McDonald, B. J. Ramshaw, Kimberly A Modic, N. Barišić, and M. Greven. “Single Reconstructed Fermi Surface Pocket in an Underdoped Single-Layer Cuprate Superconductor.” <i>Nature Communications</i>. Springer Nature, 2016. <a href=\"https://doi.org/10.1038/ncomms12244\">https://doi.org/10.1038/ncomms12244</a>.","ama":"Chan MK, Harrison N, McDonald RD, et al. Single reconstructed Fermi surface pocket in an underdoped single-layer cuprate superconductor. <i>Nature Communications</i>. 2016;7. doi:<a href=\"https://doi.org/10.1038/ncomms12244\">10.1038/ncomms12244</a>"},"extern":"1","article_type":"original","publication_status":"published","abstract":[{"lang":"eng","text":"The observation of a reconstructed Fermi surface via quantum oscillations in hole-doped cuprates opened a path towards identifying broken symmetry states in the pseudogap regime. However, such an identification has remained inconclusive due to the multi-frequency quantum oscillation spectra and complications accounting for bilayer effects in most studies. We overcome these impediments with high-resolution measurements on the structurally simpler cuprate HgBa2CuO4+δ (Hg1201), which features one CuO2 plane per primitive unit cell. We find only a single oscillatory component with no signatures of magnetic breakdown tunnelling to additional orbits. Therefore, the Fermi surface comprises a single quasi-two-dimensional pocket. Quantitative modelling of these results indicates that a biaxial charge density wave within each CuO2 plane is responsible for the reconstruction and rules out criss-crossed charge stripes between layers as a viable alternative in Hg1201. Lastly, we determine that the characteristic gap between reconstructed pockets is a significant fraction of the pseudogap energy."}],"volume":7,"language":[{"iso":"eng"}],"status":"public","article_number":"12244","quality_controlled":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":"         7","publication":"Nature Communications","doi":"10.1038/ncomms12244","oa_version":"Published Version","_id":"7069","publisher":"Springer Nature","date_created":"2019-11-19T13:21:23Z","day":"22","title":"Single reconstructed Fermi surface pocket in an underdoped single-layer cuprate superconductor","date_updated":"2021-01-12T08:11:41Z","publication_identifier":{"issn":["2041-1723"]},"month":"07","date_published":"2016-07-22T00:00:00Z","author":[{"full_name":"Chan, M. K.","last_name":"Chan","first_name":"M. K."},{"last_name":"Harrison","full_name":"Harrison, N.","first_name":"N."},{"last_name":"McDonald","full_name":"McDonald, R. D.","first_name":"R. D."},{"first_name":"B. J.","last_name":"Ramshaw","full_name":"Ramshaw, B. J."},{"first_name":"Kimberly A","id":"13C26AC0-EB69-11E9-87C6-5F3BE6697425","full_name":"Modic, Kimberly A","orcid":"0000-0001-9760-3147","last_name":"Modic"},{"first_name":"N.","full_name":"Barišić, N.","last_name":"Barišić"},{"last_name":"Greven","full_name":"Greven, M.","first_name":"M."}],"article_processing_charge":"No","year":"2016"},{"type":"journal_article","citation":{"chicago":"Rolando, Chiara, Andrea Erni, Alice Grison, Robert J Beattie, Anna Engler, Paul J. Gokhale, Marta Milo, Thomas Wegleiter, Sebastian Jessberger, and Verdon Taylor. “Multipotency of Adult Hippocampal NSCs in Vivo Is Restricted by Drosha/NFIB.” <i>Cell Stem Cell</i>. Elsevier, 2016. <a href=\"https://doi.org/10.1016/j.stem.2016.07.003\">https://doi.org/10.1016/j.stem.2016.07.003</a>.","ama":"Rolando C, Erni A, Grison A, et al. Multipotency of adult hippocampal NSCs in vivo is restricted by Drosha/NFIB. <i>Cell Stem Cell</i>. 2016;19(5):653-662. doi:<a href=\"https://doi.org/10.1016/j.stem.2016.07.003\">10.1016/j.stem.2016.07.003</a>","ista":"Rolando C, Erni A, Grison A, Beattie RJ, Engler A, Gokhale PJ, Milo M, Wegleiter T, Jessberger S, Taylor V. 2016. Multipotency of adult hippocampal NSCs in vivo is restricted by Drosha/NFIB. Cell Stem Cell. 19(5), 653–662.","mla":"Rolando, Chiara, et al. “Multipotency of Adult Hippocampal NSCs in Vivo Is Restricted by Drosha/NFIB.” <i>Cell Stem Cell</i>, vol. 19, no. 5, Elsevier, 2016, pp. 653–62, doi:<a href=\"https://doi.org/10.1016/j.stem.2016.07.003\">10.1016/j.stem.2016.07.003</a>.","apa":"Rolando, C., Erni, A., Grison, A., Beattie, R. J., Engler, A., Gokhale, P. J., … Taylor, V. (2016). Multipotency of adult hippocampal NSCs in vivo is restricted by Drosha/NFIB. <i>Cell Stem Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.stem.2016.07.003\">https://doi.org/10.1016/j.stem.2016.07.003</a>","short":"C. Rolando, A. Erni, A. Grison, R.J. Beattie, A. Engler, P.J. Gokhale, M. Milo, T. Wegleiter, S. Jessberger, V. Taylor, Cell Stem Cell 19 (2016) 653–662.","ieee":"C. Rolando <i>et al.</i>, “Multipotency of adult hippocampal NSCs in vivo is restricted by Drosha/NFIB,” <i>Cell Stem Cell</i>, vol. 19, no. 5. Elsevier, pp. 653–662, 2016."},"extern":"1","article_type":"original","publication_status":"published","volume":19,"language":[{"iso":"eng"}],"status":"public","quality_controlled":"1","issue":"5","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":"        19","doi":"10.1016/j.stem.2016.07.003","publication":"Cell Stem Cell","page":"653-662","oa_version":"None","_id":"7141","publisher":"Elsevier","date_created":"2019-11-28T13:09:09Z","day":"16","title":"Multipotency of adult hippocampal NSCs in vivo is restricted by Drosha/NFIB","date_updated":"2021-01-12T08:12:00Z","publication_identifier":{"issn":["1934-5909"]},"month":"08","date_published":"2016-08-16T00:00:00Z","author":[{"first_name":"Chiara","full_name":"Rolando, Chiara","last_name":"Rolando"},{"first_name":"Andrea","last_name":"Erni","full_name":"Erni, Andrea"},{"full_name":"Grison, Alice","last_name":"Grison","first_name":"Alice"},{"last_name":"Beattie","full_name":"Beattie, Robert J","orcid":"0000-0002-8483-8753","id":"2E26DF60-F248-11E8-B48F-1D18A9856A87","first_name":"Robert J"},{"last_name":"Engler","full_name":"Engler, Anna","first_name":"Anna"},{"first_name":"Paul J.","full_name":"Gokhale, Paul J.","last_name":"Gokhale"},{"first_name":"Marta","full_name":"Milo, Marta","last_name":"Milo"},{"first_name":"Thomas","full_name":"Wegleiter, Thomas","last_name":"Wegleiter"},{"last_name":"Jessberger","full_name":"Jessberger, Sebastian","first_name":"Sebastian"},{"first_name":"Verdon","last_name":"Taylor","full_name":"Taylor, Verdon"}],"article_processing_charge":"No","year":"2016"},{"article_processing_charge":"No","date_published":"2016-11-28T00:00:00Z","title":"Biredox ionic liquids with solid-like redox density in the liquid state for high-energy supercapacitors","date_updated":"2021-01-12T08:12:43Z","month":"11","_id":"7279","external_id":{"arxiv":["1711.11518"]},"date_created":"2020-01-15T07:27:54Z","publication":"Nature Materials","page":"446-453","intvolume":"        16","oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","issue":"4","main_file_link":[{"url":"https://arxiv.org/abs/1711.11518","open_access":"1"}],"volume":16,"extern":"1","year":"2016","author":[{"last_name":"Mourad","full_name":"Mourad, Eléonore","first_name":"Eléonore"},{"first_name":"Laura","full_name":"Coustan, Laura","last_name":"Coustan"},{"first_name":"Pierre","full_name":"Lannelongue, Pierre","last_name":"Lannelongue"},{"last_name":"Zigah","full_name":"Zigah, Dodzi","first_name":"Dodzi"},{"first_name":"Ahmad","full_name":"Mehdi, Ahmad","last_name":"Mehdi"},{"full_name":"Vioux, André","last_name":"Vioux","first_name":"André"},{"last_name":"Freunberger","orcid":"0000-0003-2902-5319","full_name":"Freunberger, Stefan Alexander","first_name":"Stefan Alexander","id":"A8CA28E6-CE23-11E9-AD2D-EC27E6697425"},{"first_name":"Frédéric","full_name":"Favier, Frédéric","last_name":"Favier"},{"full_name":"Fontaine, Olivier","last_name":"Fontaine","first_name":"Olivier"}],"publication_identifier":{"issn":["1476-1122","1476-4660"]},"publisher":"Springer Nature","day":"28","doi":"10.1038/nmat4808","oa_version":"Preprint","arxiv":1,"quality_controlled":"1","abstract":[{"lang":"eng","text":"Kinetics of electrochemical reactions are several orders of magnitude slower in solids than in liquids as a result of the much lower ion diffusivity. Yet, the solid state maximizes the density of redox species, which is at least two orders of magnitude lower in liquids because of solubility limitations. With regard to electrochemical energy storage devices, this leads to high-energy batteries with limited power and high-power supercapacitors with a well-known energy deficiency. For such devices the ideal system should endow the liquid state with a density of redox species close to the solid state. Here we report an approach based on biredox ionic liquids to achieve bulk-like redox density at liquid-like fast kinetics. The cation and anion of these biredox ionic liquids bear moieties that undergo very fast reversible redox reactions. As a first demonstration of their potential for high-capacity/high-rate charge storage, we used them in redox supercapacitors. These ionic liquids are able to decouple charge storage from an ion-accessible electrode surface, by storing significant charge in the pores of the electrodes, to minimize self-discharge and leakage current as a result of retaining the redox species in the pores, and to raise working voltage due to their wide electrochemical window."}],"publication_status":"published","status":"public","language":[{"iso":"eng"}],"article_type":"original","type":"journal_article","citation":{"chicago":"Mourad, Eléonore, Laura Coustan, Pierre Lannelongue, Dodzi Zigah, Ahmad Mehdi, André Vioux, Stefan Alexander Freunberger, Frédéric Favier, and Olivier Fontaine. “Biredox Ionic Liquids with Solid-like Redox Density in the Liquid State for High-Energy Supercapacitors.” <i>Nature Materials</i>. Springer Nature, 2016. <a href=\"https://doi.org/10.1038/nmat4808\">https://doi.org/10.1038/nmat4808</a>.","ama":"Mourad E, Coustan L, Lannelongue P, et al. Biredox ionic liquids with solid-like redox density in the liquid state for high-energy supercapacitors. <i>Nature Materials</i>. 2016;16(4):446-453. doi:<a href=\"https://doi.org/10.1038/nmat4808\">10.1038/nmat4808</a>","mla":"Mourad, Eléonore, et al. “Biredox Ionic Liquids with Solid-like Redox Density in the Liquid State for High-Energy Supercapacitors.” <i>Nature Materials</i>, vol. 16, no. 4, Springer Nature, 2016, pp. 446–53, doi:<a href=\"https://doi.org/10.1038/nmat4808\">10.1038/nmat4808</a>.","ista":"Mourad E, Coustan L, Lannelongue P, Zigah D, Mehdi A, Vioux A, Freunberger SA, Favier F, Fontaine O. 2016. Biredox ionic liquids with solid-like redox density in the liquid state for high-energy supercapacitors. Nature Materials. 16(4), 446–453.","short":"E. Mourad, L. Coustan, P. Lannelongue, D. Zigah, A. Mehdi, A. Vioux, S.A. Freunberger, F. Favier, O. Fontaine, Nature Materials 16 (2016) 446–453.","apa":"Mourad, E., Coustan, L., Lannelongue, P., Zigah, D., Mehdi, A., Vioux, A., … Fontaine, O. (2016). Biredox ionic liquids with solid-like redox density in the liquid state for high-energy supercapacitors. <i>Nature Materials</i>. Springer Nature. <a href=\"https://doi.org/10.1038/nmat4808\">https://doi.org/10.1038/nmat4808</a>","ieee":"E. Mourad <i>et al.</i>, “Biredox ionic liquids with solid-like redox density in the liquid state for high-energy supercapacitors,” <i>Nature Materials</i>, vol. 16, no. 4. Springer Nature, pp. 446–453, 2016."}},{"_id":"7293","publisher":"Elsevier","date_created":"2020-01-15T12:15:57Z","day":"21","publication":"International Journal of Hydrogen Energy","doi":"10.1016/j.ijhydene.2016.08.057","page":"22305-22315","oa_version":"None","author":[{"first_name":"Ravikumar","last_name":"Thimmappa","full_name":"Thimmappa, Ravikumar"},{"first_name":"Mruthyunjayachari","last_name":"Chattanahalli Devendrachari","full_name":"Chattanahalli Devendrachari, Mruthyunjayachari"},{"first_name":"Shahid","last_name":"Shafi","full_name":"Shafi, Shahid"},{"orcid":"0000-0003-2902-5319","full_name":"Freunberger, Stefan Alexander","last_name":"Freunberger","id":"A8CA28E6-CE23-11E9-AD2D-EC27E6697425","first_name":"Stefan Alexander"},{"first_name":"Musthafa","last_name":"Ottakam Thotiyl","full_name":"Ottakam Thotiyl, Musthafa"}],"date_published":"2016-12-21T00:00:00Z","year":"2016","article_processing_charge":"No","title":"Proton conducting hollow graphene oxide cylinder as molecular fuel barrier for tubular H2-air fuel cell","date_updated":"2021-01-12T08:12:49Z","publication_identifier":{"issn":["0360-3199"]},"month":"12","article_type":"original","citation":{"ieee":"R. Thimmappa, M. Chattanahalli Devendrachari, S. Shafi, S. A. Freunberger, and M. Ottakam Thotiyl, “Proton conducting hollow graphene oxide cylinder as molecular fuel barrier for tubular H2-air fuel cell,” <i>International Journal of Hydrogen Energy</i>, vol. 41, no. 47. Elsevier, pp. 22305–22315, 2016.","short":"R. Thimmappa, M. Chattanahalli Devendrachari, S. Shafi, S.A. Freunberger, M. Ottakam Thotiyl, International Journal of Hydrogen Energy 41 (2016) 22305–22315.","apa":"Thimmappa, R., Chattanahalli Devendrachari, M., Shafi, S., Freunberger, S. A., &#38; Ottakam Thotiyl, M. (2016). Proton conducting hollow graphene oxide cylinder as molecular fuel barrier for tubular H2-air fuel cell. <i>International Journal of Hydrogen Energy</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.ijhydene.2016.08.057\">https://doi.org/10.1016/j.ijhydene.2016.08.057</a>","ista":"Thimmappa R, Chattanahalli Devendrachari M, Shafi S, Freunberger SA, Ottakam Thotiyl M. 2016. Proton conducting hollow graphene oxide cylinder as molecular fuel barrier for tubular H2-air fuel cell. International Journal of Hydrogen Energy. 41(47), 22305–22315.","mla":"Thimmappa, Ravikumar, et al. “Proton Conducting Hollow Graphene Oxide Cylinder as Molecular Fuel Barrier for Tubular H2-Air Fuel Cell.” <i>International Journal of Hydrogen Energy</i>, vol. 41, no. 47, Elsevier, 2016, pp. 22305–15, doi:<a href=\"https://doi.org/10.1016/j.ijhydene.2016.08.057\">10.1016/j.ijhydene.2016.08.057</a>.","chicago":"Thimmappa, Ravikumar, Mruthyunjayachari Chattanahalli Devendrachari, Shahid Shafi, Stefan Alexander Freunberger, and Musthafa Ottakam Thotiyl. “Proton Conducting Hollow Graphene Oxide Cylinder as Molecular Fuel Barrier for Tubular H2-Air Fuel Cell.” <i>International Journal of Hydrogen Energy</i>. Elsevier, 2016. <a href=\"https://doi.org/10.1016/j.ijhydene.2016.08.057\">https://doi.org/10.1016/j.ijhydene.2016.08.057</a>.","ama":"Thimmappa R, Chattanahalli Devendrachari M, Shafi S, Freunberger SA, Ottakam Thotiyl M. Proton conducting hollow graphene oxide cylinder as molecular fuel barrier for tubular H2-air fuel cell. <i>International Journal of Hydrogen Energy</i>. 2016;41(47):22305-22315. doi:<a href=\"https://doi.org/10.1016/j.ijhydene.2016.08.057\">10.1016/j.ijhydene.2016.08.057</a>"},"type":"journal_article","extern":"1","quality_controlled":"1","issue":"47","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":"        41","publication_status":"published","volume":41,"abstract":[{"lang":"eng","text":"If proton exchange membrane fuel cells (PEMFC) are ever to succeed in sustainable energy landscape as a potential zero emission technology, it is inevitable to reduce electricity production cost associated mainly with its MEAs, cell hardware and gas storage units. We demonstrate a diverse strategy for achieving this target with a concomitant amplification of its specific energy and power, by rolling a thin graphene oxide (GO) based MEA alone into a tubular and air breathing architecture with internal fuel storage. The unique properties of GO being a barrier for molecular fuels and proton conducting to construct a GO based cylindrical MEA. This makes the tubular PEMFC ∼75 times lighter, featuring ∼37 and ∼92 times respectively, the power and energy per overall weight, making it a potential candidate for portable applications. The intrinsic electrochemical kinetics at the three-phase boundary are somewhat affected by the bending of the MEA, albeit at overall reduction in power production cost."}],"language":[{"iso":"eng"}],"status":"public"},{"publication":"Journal of Sol-Gel Science and Technology","doi":"10.1007/s10971-016-4037-9","oa_version":"None","page":"270-278","publisher":"Springer Nature","_id":"7294","date_created":"2020-01-15T12:16:08Z","day":"08","title":"Lithium insertion properties of mesoporous nanocrystalline TiO2 and TiO2–V2O5 microspheres prepared by non-hydrolytic sol–gel","date_updated":"2021-01-12T08:12:49Z","publication_identifier":{"issn":["0928-0707","1573-4846"]},"month":"04","date_published":"2016-04-08T00:00:00Z","author":[{"first_name":"A. M.","last_name":"Escamilla-Pérez","full_name":"Escamilla-Pérez, A. M."},{"first_name":"N.","full_name":"Louvain, N.","last_name":"Louvain"},{"last_name":"Kaschowitz","full_name":"Kaschowitz, M.","first_name":"M."},{"last_name":"Freunberger","full_name":"Freunberger, Stefan Alexander","orcid":"0000-0003-2902-5319","id":"A8CA28E6-CE23-11E9-AD2D-EC27E6697425","first_name":"Stefan Alexander"},{"full_name":"Fontaine, O.","last_name":"Fontaine","first_name":"O."},{"full_name":"Boury, B.","last_name":"Boury","first_name":"B."},{"full_name":"Brun, N.","last_name":"Brun","first_name":"N."},{"last_name":"Mutin","full_name":"Mutin, P. H.","first_name":"P. H."}],"article_processing_charge":"No","year":"2016","citation":{"ista":"Escamilla-Pérez AM, Louvain N, Kaschowitz M, Freunberger SA, Fontaine O, Boury B, Brun N, Mutin PH. 2016. Lithium insertion properties of mesoporous nanocrystalline TiO2 and TiO2–V2O5 microspheres prepared by non-hydrolytic sol–gel. Journal of Sol-Gel Science and Technology. 79(2), 270–278.","mla":"Escamilla-Pérez, A. M., et al. “Lithium Insertion Properties of Mesoporous Nanocrystalline TiO2 and TiO2–V2O5 Microspheres Prepared by Non-Hydrolytic Sol–Gel.” <i>Journal of Sol-Gel Science and Technology</i>, vol. 79, no. 2, Springer Nature, 2016, pp. 270–78, doi:<a href=\"https://doi.org/10.1007/s10971-016-4037-9\">10.1007/s10971-016-4037-9</a>.","ama":"Escamilla-Pérez AM, Louvain N, Kaschowitz M, et al. Lithium insertion properties of mesoporous nanocrystalline TiO2 and TiO2–V2O5 microspheres prepared by non-hydrolytic sol–gel. <i>Journal of Sol-Gel Science and Technology</i>. 2016;79(2):270-278. doi:<a href=\"https://doi.org/10.1007/s10971-016-4037-9\">10.1007/s10971-016-4037-9</a>","chicago":"Escamilla-Pérez, A. M., N. Louvain, M. Kaschowitz, Stefan Alexander Freunberger, O. Fontaine, B. Boury, N. Brun, and P. H. Mutin. “Lithium Insertion Properties of Mesoporous Nanocrystalline TiO2 and TiO2–V2O5 Microspheres Prepared by Non-Hydrolytic Sol–Gel.” <i>Journal of Sol-Gel Science and Technology</i>. Springer Nature, 2016. <a href=\"https://doi.org/10.1007/s10971-016-4037-9\">https://doi.org/10.1007/s10971-016-4037-9</a>.","ieee":"A. M. Escamilla-Pérez <i>et al.</i>, “Lithium insertion properties of mesoporous nanocrystalline TiO2 and TiO2–V2O5 microspheres prepared by non-hydrolytic sol–gel,” <i>Journal of Sol-Gel Science and Technology</i>, vol. 79, no. 2. Springer Nature, pp. 270–278, 2016.","short":"A.M. Escamilla-Pérez, N. Louvain, M. Kaschowitz, S.A. Freunberger, O. Fontaine, B. Boury, N. Brun, P.H. Mutin, Journal of Sol-Gel Science and Technology 79 (2016) 270–278.","apa":"Escamilla-Pérez, A. M., Louvain, N., Kaschowitz, M., Freunberger, S. A., Fontaine, O., Boury, B., … Mutin, P. H. (2016). Lithium insertion properties of mesoporous nanocrystalline TiO2 and TiO2–V2O5 microspheres prepared by non-hydrolytic sol–gel. <i>Journal of Sol-Gel Science and Technology</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s10971-016-4037-9\">https://doi.org/10.1007/s10971-016-4037-9</a>"},"type":"journal_article","extern":"1","article_type":"original","abstract":[{"text":"Mesoporous nanocrystalline TiO2 and TiO2–V2O5 microspheres were prepared by non-hydrolytic sol–gel from TiCl4, VOCl3, and iPr2O at 110 °C without any solvent or additives. The samples were characterized by elemental analysis, X-ray diffraction, Raman spectroscopy, scanning electron microscopy, nitrogen physisorption, and impedance measurements. At low vanadium loadings, only TiO2 anatase was detected, and V2O5 scherbinaite was also detected at high vanadium loadings. The texture of the samples depended on the V loading, but all the samples appeared built of primary nanoparticles (≈10–20 nm in size) that aggregate to form mesoporous micron-sized spheres. The lithium insertion properties of these materials were evaluated by galvanostatic measurements taken using coin-type cells, in view of their application as electrode for rechargeable Li-ion batteries. The mesoporous TiO2 microspheres showed good performances, with a specific reversible capacity of 145 and 128 mAh g−1 at C/2 and C, respectively (C = 335.6 mA g−1), good coulombic efficiency, and a moderate capacity fade (6 %) from the 2nd to the 20th cycle at C/20. Although the addition of V effectively increased the electronic conductivity of the powders, the specific reversible capacity and cycling performances of the TiO2–V2O5 samples were only minimally improved for a 5 at% V loading and were lower at higher V loading.","lang":"eng"}],"volume":79,"publication_status":"published","language":[{"iso":"eng"}],"status":"public","quality_controlled":"1","issue":"2","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":"        79"},{"month":"07","date_updated":"2021-01-12T08:12:50Z","title":"Biredox ionic liquids: Electrochemical investigation and impact of ion size on electron transfer","publication_identifier":{"issn":["0013-4686"]},"author":[{"last_name":"Mourad","full_name":"Mourad, Eléonore","first_name":"Eléonore"},{"last_name":"Coustan","full_name":"Coustan, Laura","first_name":"Laura"},{"first_name":"Stefan Alexander","id":"A8CA28E6-CE23-11E9-AD2D-EC27E6697425","orcid":"0000-0003-2902-5319","full_name":"Freunberger, Stefan Alexander","last_name":"Freunberger"},{"first_name":"Ahmad","last_name":"Mehdi","full_name":"Mehdi, Ahmad"},{"first_name":"André","full_name":"Vioux, André","last_name":"Vioux"},{"first_name":"Frédérique","full_name":"Favier, Frédérique","last_name":"Favier"},{"full_name":"Fontaine, Olivier","last_name":"Fontaine","first_name":"Olivier"}],"date_published":"2016-07-10T00:00:00Z","year":"2016","article_processing_charge":"No","oa_version":"None","page":"513-523","publication":"Electrochimica Acta","doi":"10.1016/j.electacta.2016.02.211","date_created":"2020-01-15T12:16:17Z","day":"10","_id":"7295","publisher":"Elsevier","language":[{"iso":"eng"}],"status":"public","volume":206,"publication_status":"published","abstract":[{"lang":"eng","text":"Redox ionic liquids consisting of ions bearing redox moieties are receiving increasing interest in electrochemical applications, as they associate electroactive properties with the classical properties of ionic liquids. Here, biredox ionic liquid electrolytes are described in which both anion and cation are functionalized with anthraquinone and 2,2,6,6-tetramethylpiperidinyl-1-oxyl (TEMPO) groups, respectively. In-depth investigations based on crossed experimental and theoretical studies were carried out to elucidate how the bulkiness of ions bearing a redox moiety impacted electron and mass transfers, and accordingly the efficiency of electrochemical devices. The values of solvated radii of different redox ions, as well as the related kinetic constants, were extracted from cyclic voltammetry experiments. Reformulating the basic relations of electron transfer theory (based on Marcus-Hush theory) evidenced that in such redox species, with an unsymmetrical located redox centre, the electron transfer was not governed by the overall size of the solvated redox species, but rather by the radius of the redox active subunit, which takes preferential orientation towards the surface, thus allowing higher kinetic constants than what classical theory would predict. This vision opens ample opportunities for biredox ILs as electrolytes in electrochemical devices."}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","issue":"7","intvolume":"       206","quality_controlled":"1","type":"journal_article","citation":{"mla":"Mourad, Eléonore, et al. “Biredox Ionic Liquids: Electrochemical Investigation and Impact of Ion Size on Electron Transfer.” <i>Electrochimica Acta</i>, vol. 206, no. 7, Elsevier, 2016, pp. 513–23, doi:<a href=\"https://doi.org/10.1016/j.electacta.2016.02.211\">10.1016/j.electacta.2016.02.211</a>.","ista":"Mourad E, Coustan L, Freunberger SA, Mehdi A, Vioux A, Favier F, Fontaine O. 2016. Biredox ionic liquids: Electrochemical investigation and impact of ion size on electron transfer. Electrochimica Acta. 206(7), 513–523.","ama":"Mourad E, Coustan L, Freunberger SA, et al. Biredox ionic liquids: Electrochemical investigation and impact of ion size on electron transfer. <i>Electrochimica Acta</i>. 2016;206(7):513-523. doi:<a href=\"https://doi.org/10.1016/j.electacta.2016.02.211\">10.1016/j.electacta.2016.02.211</a>","chicago":"Mourad, Eléonore, Laura Coustan, Stefan Alexander Freunberger, Ahmad Mehdi, André Vioux, Frédérique Favier, and Olivier Fontaine. “Biredox Ionic Liquids: Electrochemical Investigation and Impact of Ion Size on Electron Transfer.” <i>Electrochimica Acta</i>. Elsevier, 2016. <a href=\"https://doi.org/10.1016/j.electacta.2016.02.211\">https://doi.org/10.1016/j.electacta.2016.02.211</a>.","ieee":"E. Mourad <i>et al.</i>, “Biredox ionic liquids: Electrochemical investigation and impact of ion size on electron transfer,” <i>Electrochimica Acta</i>, vol. 206, no. 7. Elsevier, pp. 513–523, 2016.","short":"E. Mourad, L. Coustan, S.A. Freunberger, A. Mehdi, A. Vioux, F. Favier, O. Fontaine, Electrochimica Acta 206 (2016) 513–523.","apa":"Mourad, E., Coustan, L., Freunberger, S. A., Mehdi, A., Vioux, A., Favier, F., &#38; Fontaine, O. (2016). Biredox ionic liquids: Electrochemical investigation and impact of ion size on electron transfer. <i>Electrochimica Acta</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.electacta.2016.02.211\">https://doi.org/10.1016/j.electacta.2016.02.211</a>"},"extern":"1","article_type":"original"},{"publication_identifier":{"issn":["2313-0105"]},"date_updated":"2021-01-12T08:12:50Z","title":"Method for determination of the internal short resistance and heat evolution at different mechanical loads of a Lithium ion battery cell based on dummy pouch cells","month":"04","article_processing_charge":"No","year":"2016","date_published":"2016-04-07T00:00:00Z","author":[{"full_name":"Volck, Theo","last_name":"Volck","first_name":"Theo"},{"first_name":"Wolfgang","full_name":"Sinz, Wolfgang","last_name":"Sinz"},{"first_name":"Gregor","full_name":"Gstrein, Gregor","last_name":"Gstrein"},{"first_name":"Christoph","full_name":"Breitfuss, Christoph","last_name":"Breitfuss"},{"first_name":"Simon","full_name":"Heindl, Simon","last_name":"Heindl"},{"last_name":"Steffan","full_name":"Steffan, Hermann","first_name":"Hermann"},{"first_name":"Stefan Alexander","id":"A8CA28E6-CE23-11E9-AD2D-EC27E6697425","full_name":"Freunberger, Stefan Alexander","orcid":"0000-0003-2902-5319","last_name":"Freunberger"},{"full_name":"Wilkening, Martin","last_name":"Wilkening","first_name":"Martin"},{"first_name":"Marlena","full_name":"Uitz, Marlena","last_name":"Uitz"},{"full_name":"Fink, Clemens","last_name":"Fink","first_name":"Clemens"},{"first_name":"Alexander","full_name":"Geier, Alexander","last_name":"Geier"}],"publication":"Batteries","doi":"10.3390/batteries2020008","oa_version":"Published Version","_id":"7296","publisher":"MDPI AG","day":"07","date_created":"2020-01-15T12:16:31Z","publication_status":"published","abstract":[{"lang":"eng","text":"Within the scope of developing a multi-physical model describing battery behavior during and after the mechanical load (accelerations, intrusions) of a vehicle’s high voltage battery, an internal short circuit model is of deep interest for a virtual hazard assessment. The internal short resistance and the size of the affected area must be known as a minimum for determining the released heat and, in consequence, the temperatures. The internal short resistance of purpose-built dummy pouch cells, filled with electrolyte-like solvent without conductive salt, has thus been measured in a given short area under various compressive loads. The resistances for different short scenarios obtained are analyzed and described in a mathematical form. Short circuit experiments with dummy cells using an external power source have also been carried out. This set-up allows the measurement of the temperature evolution at a known current and a determination of the actual short resistance. The post-mortem analysis of the samples shows a correlation between the maximum temperatures, released short heat and the separator melt diameter."}],"volume":2,"status":"public","language":[{"iso":"eng"}],"quality_controlled":"1","article_number":"8","intvolume":"         2","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","issue":"2","extern":"1","type":"journal_article","citation":{"short":"T. Volck, W. Sinz, G. Gstrein, C. Breitfuss, S. Heindl, H. Steffan, S.A. Freunberger, M. Wilkening, M. Uitz, C. Fink, A. Geier, Batteries 2 (2016).","apa":"Volck, T., Sinz, W., Gstrein, G., Breitfuss, C., Heindl, S., Steffan, H., … Geier, A. (2016). Method for determination of the internal short resistance and heat evolution at different mechanical loads of a Lithium ion battery cell based on dummy pouch cells. <i>Batteries</i>. MDPI AG. <a href=\"https://doi.org/10.3390/batteries2020008\">https://doi.org/10.3390/batteries2020008</a>","ieee":"T. Volck <i>et al.</i>, “Method for determination of the internal short resistance and heat evolution at different mechanical loads of a Lithium ion battery cell based on dummy pouch cells,” <i>Batteries</i>, vol. 2, no. 2. MDPI AG, 2016.","chicago":"Volck, Theo, Wolfgang Sinz, Gregor Gstrein, Christoph Breitfuss, Simon Heindl, Hermann Steffan, Stefan Alexander Freunberger, et al. “Method for Determination of the Internal Short Resistance and Heat Evolution at Different Mechanical Loads of a Lithium Ion Battery Cell Based on Dummy Pouch Cells.” <i>Batteries</i>. MDPI AG, 2016. <a href=\"https://doi.org/10.3390/batteries2020008\">https://doi.org/10.3390/batteries2020008</a>.","ama":"Volck T, Sinz W, Gstrein G, et al. Method for determination of the internal short resistance and heat evolution at different mechanical loads of a Lithium ion battery cell based on dummy pouch cells. <i>Batteries</i>. 2016;2(2). doi:<a href=\"https://doi.org/10.3390/batteries2020008\">10.3390/batteries2020008</a>","mla":"Volck, Theo, et al. “Method for Determination of the Internal Short Resistance and Heat Evolution at Different Mechanical Loads of a Lithium Ion Battery Cell Based on Dummy Pouch Cells.” <i>Batteries</i>, vol. 2, no. 2, 8, MDPI AG, 2016, doi:<a href=\"https://doi.org/10.3390/batteries2020008\">10.3390/batteries2020008</a>.","ista":"Volck T, Sinz W, Gstrein G, Breitfuss C, Heindl S, Steffan H, Freunberger SA, Wilkening M, Uitz M, Fink C, Geier A. 2016. Method for determination of the internal short resistance and heat evolution at different mechanical loads of a Lithium ion battery cell based on dummy pouch cells. Batteries. 2(2), 8."},"article_type":"original"},{"oa":1,"intvolume":"         1","issue":"6","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_number":"16074","volume":1,"extern":"1","article_processing_charge":"No","date_published":"2016-05-23T00:00:00Z","month":"05","title":"Batteries: Charging ahead rationally","date_updated":"2021-01-12T08:12:51Z","date_created":"2020-01-15T12:16:40Z","_id":"7297","publication":"Nature Energy","file_date_updated":"2020-07-14T12:47:55Z","quality_controlled":"1","status":"public","has_accepted_license":"1","language":[{"iso":"eng"}],"publication_status":"published","abstract":[{"lang":"eng","text":"Redox mediators facilitate the oxidation of the highly insulating discharge product in metal–oxygen batteries during recharge and offer opportunities to achieve high reversible capacities. Now a design principle for selecting redox mediators that can recharge the batteries more efficiently is suggested."}],"article_type":"original","ddc":["540","541","547","546"],"citation":{"ieee":"S. A. Freunberger, “Batteries: Charging ahead rationally,” <i>Nature Energy</i>, vol. 1, no. 6. Springer Nature, 2016.","apa":"Freunberger, S. A. (2016). Batteries: Charging ahead rationally. <i>Nature Energy</i>. Springer Nature. <a href=\"https://doi.org/10.1038/nenergy.2016.74\">https://doi.org/10.1038/nenergy.2016.74</a>","short":"S.A. Freunberger, Nature Energy 1 (2016).","ista":"Freunberger SA. 2016. Batteries: Charging ahead rationally. Nature Energy. 1(6), 16074.","mla":"Freunberger, Stefan Alexander. “Batteries: Charging Ahead Rationally.” <i>Nature Energy</i>, vol. 1, no. 6, 16074, Springer Nature, 2016, doi:<a href=\"https://doi.org/10.1038/nenergy.2016.74\">10.1038/nenergy.2016.74</a>.","ama":"Freunberger SA. Batteries: Charging ahead rationally. <i>Nature Energy</i>. 2016;1(6). doi:<a href=\"https://doi.org/10.1038/nenergy.2016.74\">10.1038/nenergy.2016.74</a>","chicago":"Freunberger, Stefan Alexander. “Batteries: Charging Ahead Rationally.” <i>Nature Energy</i>. Springer Nature, 2016. <a href=\"https://doi.org/10.1038/nenergy.2016.74\">https://doi.org/10.1038/nenergy.2016.74</a>."},"type":"journal_article","file":[{"file_id":"8047","creator":"sfreunbe","date_created":"2020-06-29T13:41:56Z","checksum":"d90d675947262f7437b483b251918df2","relation":"main_file","content_type":"application/pdf","date_updated":"2020-07-14T12:47:55Z","file_size":197375,"file_name":"N&V Freunberger final.pdf","access_level":"open_access"}],"year":"2016","author":[{"last_name":"Freunberger","orcid":"0000-0003-2902-5319","full_name":"Freunberger, Stefan Alexander","first_name":"Stefan Alexander","id":"A8CA28E6-CE23-11E9-AD2D-EC27E6697425"}],"publication_identifier":{"issn":["2058-7546"]},"day":"23","publisher":"Springer Nature","oa_version":"Submitted Version","doi":"10.1038/nenergy.2016.74"},{"type":"journal_article","citation":{"ama":"Plaimer M, Breitfuß C, Sinz W, et al. Evaluating the trade-off between mechanical and electrochemical performance of separators for lithium-ion batteries: Methodology and application. <i>Journal of Power Sources</i>. 2016;306(2):702-710. doi:<a href=\"https://doi.org/10.1016/j.jpowsour.2015.12.047\">10.1016/j.jpowsour.2015.12.047</a>","chicago":"Plaimer, Martin, Christoph Breitfuß, Wolfgang Sinz, Simon F. Heindl, Christian Ellersdorfer, Hermann Steffan, Martin Wilkening, et al. “Evaluating the Trade-off between Mechanical and Electrochemical Performance of Separators for Lithium-Ion Batteries: Methodology and Application.” <i>Journal of Power Sources</i>. Elsevier, 2016. <a href=\"https://doi.org/10.1016/j.jpowsour.2015.12.047\">https://doi.org/10.1016/j.jpowsour.2015.12.047</a>.","mla":"Plaimer, Martin, et al. “Evaluating the Trade-off between Mechanical and Electrochemical Performance of Separators for Lithium-Ion Batteries: Methodology and Application.” <i>Journal of Power Sources</i>, vol. 306, no. 2, Elsevier, 2016, pp. 702–10, doi:<a href=\"https://doi.org/10.1016/j.jpowsour.2015.12.047\">10.1016/j.jpowsour.2015.12.047</a>.","ista":"Plaimer M, Breitfuß C, Sinz W, Heindl SF, Ellersdorfer C, Steffan H, Wilkening M, Hennige V, Tatschl R, Geier A, Schramm C, Freunberger SA. 2016. Evaluating the trade-off between mechanical and electrochemical performance of separators for lithium-ion batteries: Methodology and application. Journal of Power Sources. 306(2), 702–710.","apa":"Plaimer, M., Breitfuß, C., Sinz, W., Heindl, S. F., Ellersdorfer, C., Steffan, H., … Freunberger, S. A. (2016). Evaluating the trade-off between mechanical and electrochemical performance of separators for lithium-ion batteries: Methodology and application. <i>Journal of Power Sources</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.jpowsour.2015.12.047\">https://doi.org/10.1016/j.jpowsour.2015.12.047</a>","short":"M. Plaimer, C. Breitfuß, W. Sinz, S.F. Heindl, C. Ellersdorfer, H. Steffan, M. Wilkening, V. Hennige, R. Tatschl, A. Geier, C. Schramm, S.A. Freunberger, Journal of Power Sources 306 (2016) 702–710.","ieee":"M. Plaimer <i>et al.</i>, “Evaluating the trade-off between mechanical and electrochemical performance of separators for lithium-ion batteries: Methodology and application,” <i>Journal of Power Sources</i>, vol. 306, no. 2. Elsevier, pp. 702–710, 2016."},"extern":"1","article_type":"original","language":[{"iso":"eng"}],"status":"public","publication_status":"published","abstract":[{"text":"Lithium-ion batteries are in widespread use in electric vehicles and hybrid vehicles. Besides features like energy density, cost, lifetime, and recyclability the safety of a battery system is of prime importance. The separator material impacts all these properties and requires therefore an informed selection. The interplay between the mechanical and electrochemical properties as key selection criteria is investigated. Mechanical properties were investigated using tensile and puncture penetration tests at abuse relevant conditions. To investigate the electrochemical performance in terms of effective conductivity a method based on impedance spectroscopy was introduced. This methodology is applied to evaluate ten commercial separators which allows for a trade-off analysis of mechanical versus electrochemical performance. Based on the results, and in combination with other factors, this offers an effective approach to select suitable separators for automotive applications.","lang":"eng"}],"volume":306,"issue":"2","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":"       306","quality_controlled":"1","oa_version":"None","page":"702-710","doi":"10.1016/j.jpowsour.2015.12.047","publication":"Journal of Power Sources","date_created":"2020-01-15T12:16:51Z","day":"29","publisher":"Elsevier","_id":"7298","month":"02","date_updated":"2021-01-12T08:12:51Z","title":"Evaluating the trade-off between mechanical and electrochemical performance of separators for lithium-ion batteries: Methodology and application","publication_identifier":{"issn":["0378-7753"]},"date_published":"2016-02-29T00:00:00Z","author":[{"first_name":"Martin","last_name":"Plaimer","full_name":"Plaimer, Martin"},{"first_name":"Christoph","full_name":"Breitfuß, Christoph","last_name":"Breitfuß"},{"first_name":"Wolfgang","full_name":"Sinz, Wolfgang","last_name":"Sinz"},{"last_name":"Heindl","full_name":"Heindl, Simon F.","first_name":"Simon F."},{"first_name":"Christian","full_name":"Ellersdorfer, Christian","last_name":"Ellersdorfer"},{"last_name":"Steffan","full_name":"Steffan, Hermann","first_name":"Hermann"},{"first_name":"Martin","full_name":"Wilkening, Martin","last_name":"Wilkening"},{"full_name":"Hennige, Volker","last_name":"Hennige","first_name":"Volker"},{"last_name":"Tatschl","full_name":"Tatschl, Reinhard","first_name":"Reinhard"},{"first_name":"Alexander","full_name":"Geier, Alexander","last_name":"Geier"},{"first_name":"Christian","last_name":"Schramm","full_name":"Schramm, Christian"},{"id":"A8CA28E6-CE23-11E9-AD2D-EC27E6697425","first_name":"Stefan Alexander","orcid":"0000-0003-2902-5319","full_name":"Freunberger, Stefan Alexander","last_name":"Freunberger"}],"year":"2016","article_processing_charge":"No"},{"volume":12,"article_number":"e1006252","oa":1,"intvolume":"        12","issue":"8","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","extern":"1","date_updated":"2021-01-12T08:14:25Z","title":"Arabidopsis type II phosphatidylinositol 4-kinase PI4Kγ5 regulates auxin biosynthesis and leaf margin development through interacting with membrane-bound transcription factor ANAC078","month":"08","article_processing_charge":"No","date_published":"2016-08-16T00:00:00Z","publication":"PLOS Genetics","file_date_updated":"2020-07-14T12:48:01Z","_id":"7599","date_created":"2020-03-21T16:08:33Z","abstract":[{"text":"Normal leaf margin development is important for leaf morphogenesis and contributes to diverse leaf shapes in higher plants. We here show the crucial roles of an atypical type II phosphatidylinositol 4-kinase, PI4Kγ5, in Arabidopsis leaf margin development. PI4Kγ5 presents a dynamics expression pattern along with leaf development and a T-DNA mutant lacking PI4Kγ5, pi4kγ5–1, presents serrated leaves, which is resulted from the accelerated cell division and increased auxin concentration at serration tips. Studies revealed that PI4Kγ5 interacts with and phosphorylates a membrane-bound NAC transcription factor, ANAC078. Previous studies demonstrated that membrane-bound transcription factors regulate gene transcription by undergoing proteolytic process to translocate into nucleus, and ANAC078 undergoes proteolysis by cleaving off the transmembrane region and carboxyl terminal. Western blot analysis indeed showed that ANAC078 deleting of carboxyl terminal is significantly reduced in pi4kγ5–1, indicating that PI4Kγ5 is important for the cleavage of ANAC078. This is consistent with the subcellular localization observation showing that fluorescence by GFP-ANAC078 is detected at plasma membrane but not nucleus in pi4kγ5–1 mutant and that expression of ANAC078 deleting of carboxyl terminal, driven by PI4Kγ5 promoter, could rescue the leaf serration defects of pi4kγ5–1. Further analysis showed that ANAC078 suppresses the auxin synthesis by directly binding and regulating the expression of auxin synthesis-related genes. These results indicate that PI4Kγ5 interacts with ANAC078 to negatively regulate auxin synthesis and hence influences cell proliferation and leaf development, providing informative clues for the regulation of in situ auxin synthesis and cell division, as well as the cleavage and functional mechanism of membrane-bound transcription factors.","lang":"eng"}],"publication_status":"published","status":"public","has_accepted_license":"1","language":[{"iso":"eng"}],"quality_controlled":"1","file":[{"date_updated":"2020-07-14T12:48:01Z","content_type":"application/pdf","file_size":3266119,"checksum":"ff0ab9a6bed11cda800a6e59820866a0","relation":"main_file","access_level":"open_access","file_name":"2016_PlosGenetics_Tang.PDF","file_id":"7612","date_created":"2020-03-23T12:15:31Z","creator":"dernst"}],"type":"journal_article","citation":{"chicago":"Tang, Yong, Chun-Yan Zhao, Shutang Tan, and Hong-Wei Xue. “Arabidopsis Type II Phosphatidylinositol 4-Kinase PI4Kγ5 Regulates Auxin Biosynthesis and Leaf Margin Development through Interacting with Membrane-Bound Transcription Factor ANAC078.” <i>PLOS Genetics</i>. Public Library of Science, 2016. <a href=\"https://doi.org/10.1371/journal.pgen.1006252\">https://doi.org/10.1371/journal.pgen.1006252</a>.","ama":"Tang Y, Zhao C-Y, Tan S, Xue H-W. Arabidopsis type II phosphatidylinositol 4-kinase PI4Kγ5 regulates auxin biosynthesis and leaf margin development through interacting with membrane-bound transcription factor ANAC078. <i>PLOS Genetics</i>. 2016;12(8). doi:<a href=\"https://doi.org/10.1371/journal.pgen.1006252\">10.1371/journal.pgen.1006252</a>","ista":"Tang Y, Zhao C-Y, Tan S, Xue H-W. 2016. Arabidopsis type II phosphatidylinositol 4-kinase PI4Kγ5 regulates auxin biosynthesis and leaf margin development through interacting with membrane-bound transcription factor ANAC078. PLOS Genetics. 12(8), e1006252.","mla":"Tang, Yong, et al. “Arabidopsis Type II Phosphatidylinositol 4-Kinase PI4Kγ5 Regulates Auxin Biosynthesis and Leaf Margin Development through Interacting with Membrane-Bound Transcription Factor ANAC078.” <i>PLOS Genetics</i>, vol. 12, no. 8, e1006252, Public Library of Science, 2016, doi:<a href=\"https://doi.org/10.1371/journal.pgen.1006252\">10.1371/journal.pgen.1006252</a>.","apa":"Tang, Y., Zhao, C.-Y., Tan, S., &#38; Xue, H.-W. (2016). Arabidopsis type II phosphatidylinositol 4-kinase PI4Kγ5 regulates auxin biosynthesis and leaf margin development through interacting with membrane-bound transcription factor ANAC078. <i>PLOS Genetics</i>. Public Library of Science. <a href=\"https://doi.org/10.1371/journal.pgen.1006252\">https://doi.org/10.1371/journal.pgen.1006252</a>","short":"Y. Tang, C.-Y. Zhao, S. Tan, H.-W. Xue, PLOS Genetics 12 (2016).","ieee":"Y. Tang, C.-Y. Zhao, S. Tan, and H.-W. Xue, “Arabidopsis type II phosphatidylinositol 4-kinase PI4Kγ5 regulates auxin biosynthesis and leaf margin development through interacting with membrane-bound transcription factor ANAC078,” <i>PLOS Genetics</i>, vol. 12, no. 8. Public Library of Science, 2016."},"ddc":["580"],"article_type":"original","publication_identifier":{"issn":["1553-7404"]},"tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"year":"2016","author":[{"last_name":"Tang","full_name":"Tang, Yong","first_name":"Yong"},{"first_name":"Chun-Yan","last_name":"Zhao","full_name":"Zhao, Chun-Yan"},{"last_name":"Tan","full_name":"Tan, Shutang","orcid":"0000-0002-0471-8285","id":"2DE75584-F248-11E8-B48F-1D18A9856A87","first_name":"Shutang"},{"full_name":"Xue, Hong-Wei","last_name":"Xue","first_name":"Hong-Wei"}],"doi":"10.1371/journal.pgen.1006252","oa_version":"Published Version","publisher":"Public Library of Science","day":"16"},{"publication_status":"published","abstract":[{"text":"Importance: Considerable partner resemblances have been found for a wide range of psychiatric disorders, meaning that partners of affected individuals have an increased risk of being affected compared with partners of unaffected individuals. If this resemblance is reflected in genetic similarity between partners, genetic risk is anticipated to accumulate in offspring, but these potential consequences have not been quantified and have been left implicit.\r\n\r\nObservations: The anticipated consequences of partner resemblance on prevalence and heritability of psychiatric traits in the offspring generation were modeled for disorders with varying heritabilities, population prevalence (lifetime risk), and magnitudes of partner resemblance. These models facilitate interpretation for a wide range of psychiatric disorders, such as autism, schizophrenia, and depression. The genetic consequences of partner resemblance are most pronounced when attributable to phenotypic assortment (driven by the psychiatric trait). Phenotypic assortment results in increased genetic variance in the offspring generation, which may result in increased heritability and population prevalence. These consequences add generation after generation to a limit, but assortative mating is unlikely to balance the impact of reduced fecundity of patients with psychiatric disorders in the long term. This modeling suggests that the heritabilities of psychiatric disorders are unlikely to increase by more than 5% from 1 generation of assortative mating (maximally 13% across multiple generations). The population prevalence will increase most for less common disorders with high heritability; for example, the prevalence of autism might increase by 1.5-fold after 1 generation of assortative mating (≥2.4-fold in the long term) depending on several assumptions.\r\n\r\nConclusions and Relevance: The considerable partner resemblances found for psychiatric disorders deserve more detailed interpretation than has been provided thus far. Although the limitations of modeling are emphasized, the anticipated consequences are at most modest for the heritability but may be considerable for the population prevalence of rare disorders with a high heritability.","lang":"eng"}],"volume":73,"status":"public","language":[{"iso":"eng"}],"quality_controlled":"1","intvolume":"        73","issue":"11","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","extern":"1","type":"journal_article","citation":{"ieee":"W. J. Peyrot, M. R. Robinson, B. W. J. H. Penninx, and N. R. Wray, “Exploring boundaries for the genetic consequences of assortative mating for psychiatric traits,” <i>JAMA Psychiatry</i>, vol. 73, no. 11. American Medical Association, pp. 1189–1195, 2016.","short":"W.J. Peyrot, M.R. Robinson, B.W.J.H. Penninx, N.R. Wray, JAMA Psychiatry 73 (2016) 1189–1195.","apa":"Peyrot, W. J., Robinson, M. R., Penninx, B. W. J. H., &#38; Wray, N. R. (2016). Exploring boundaries for the genetic consequences of assortative mating for psychiatric traits. <i>JAMA Psychiatry</i>. American Medical Association. <a href=\"https://doi.org/10.1001/jamapsychiatry.2016.2566\">https://doi.org/10.1001/jamapsychiatry.2016.2566</a>","mla":"Peyrot, Wouter J., et al. “Exploring Boundaries for the Genetic Consequences of Assortative Mating for Psychiatric Traits.” <i>JAMA Psychiatry</i>, vol. 73, no. 11, American Medical Association, 2016, pp. 1189–95, doi:<a href=\"https://doi.org/10.1001/jamapsychiatry.2016.2566\">10.1001/jamapsychiatry.2016.2566</a>.","ista":"Peyrot WJ, Robinson MR, Penninx BWJH, Wray NR. 2016. Exploring boundaries for the genetic consequences of assortative mating for psychiatric traits. JAMA Psychiatry. 73(11), 1189–1195.","ama":"Peyrot WJ, Robinson MR, Penninx BWJH, Wray NR. Exploring boundaries for the genetic consequences of assortative mating for psychiatric traits. <i>JAMA Psychiatry</i>. 2016;73(11):1189-1195. doi:<a href=\"https://doi.org/10.1001/jamapsychiatry.2016.2566\">10.1001/jamapsychiatry.2016.2566</a>","chicago":"Peyrot, Wouter J., Matthew Richard Robinson, Brenda W. J. H. Penninx, and Naomi R. Wray. “Exploring Boundaries for the Genetic Consequences of Assortative Mating for Psychiatric Traits.” <i>JAMA Psychiatry</i>. American Medical Association, 2016. <a href=\"https://doi.org/10.1001/jamapsychiatry.2016.2566\">https://doi.org/10.1001/jamapsychiatry.2016.2566</a>."},"article_type":"original","publication_identifier":{"issn":["2168-622X"]},"title":"Exploring boundaries for the genetic consequences of assortative mating for psychiatric traits","date_updated":"2021-01-12T08:15:11Z","month":"11","year":"2016","article_processing_charge":"No","author":[{"first_name":"Wouter J.","full_name":"Peyrot, Wouter J.","last_name":"Peyrot"},{"full_name":"Robinson, Matthew Richard","orcid":"0000-0001-8982-8813","last_name":"Robinson","id":"E5D42276-F5DA-11E9-8E24-6303E6697425","first_name":"Matthew Richard"},{"last_name":"Penninx","full_name":"Penninx, Brenda W. J. H.","first_name":"Brenda W. J. H."},{"last_name":"Wray","full_name":"Wray, Naomi R.","first_name":"Naomi R."}],"date_published":"2016-11-01T00:00:00Z","doi":"10.1001/jamapsychiatry.2016.2566","publication":"JAMA Psychiatry","oa_version":"None","page":"1189-1195","publisher":"American Medical Association","_id":"7734","day":"01","date_created":"2020-04-30T10:48:41Z"}]