[{"status":"public","title":"IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses","author":[{"last_name":"Chen","first_name":"Changchun","full_name":"Chen, Changchun"},{"full_name":"Itakura, Eisuke","last_name":"Itakura","first_name":"Eisuke"},{"first_name":"Geoffrey M.","last_name":"Nelson","full_name":"Nelson, Geoffrey M."},{"full_name":"Sheng, Ming","last_name":"Sheng","first_name":"Ming"},{"full_name":"Laurent, Patrick","first_name":"Patrick","last_name":"Laurent"},{"last_name":"Fenk","first_name":"Lorenz A.","full_name":"Fenk, Lorenz A."},{"full_name":"Butcher, Rebecca A.","first_name":"Rebecca A.","last_name":"Butcher"},{"full_name":"Hegde, Ramanujan S.","first_name":"Ramanujan S.","last_name":"Hegde"},{"first_name":"Mario","orcid":"0000-0001-8347-0443","last_name":"de Bono","id":"4E3FF80E-F248-11E8-B48F-1D18A9856A87","full_name":"de Bono, Mario"}],"oa":1,"issue":"7639","intvolume":"       542","publication":"Nature","publisher":"Springer Nature","main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pubmed/28099418","open_access":"1"}],"quality_controlled":"1","page":"43-48","volume":542,"month":"02","date_created":"2019-03-19T14:06:41Z","date_published":"2017-02-02T00:00:00Z","date_updated":"2021-01-12T08:06:12Z","citation":{"ista":"Chen C, Itakura E, Nelson GM, Sheng M, Laurent P, Fenk LA, Butcher RA, Hegde RS, de Bono M. 2017. IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses. Nature. 542(7639), 43–48.","ama":"Chen C, Itakura E, Nelson GM, et al. IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses. <i>Nature</i>. 2017;542(7639):43-48. doi:<a href=\"https://doi.org/10.1038/nature20818\">10.1038/nature20818</a>","mla":"Chen, Changchun, et al. “IL-17 Is a Neuromodulator of Caenorhabditis Elegans Sensory Responses.” <i>Nature</i>, vol. 542, no. 7639, Springer Nature, 2017, pp. 43–48, doi:<a href=\"https://doi.org/10.1038/nature20818\">10.1038/nature20818</a>.","chicago":"Chen, Changchun, Eisuke Itakura, Geoffrey M. Nelson, Ming Sheng, Patrick Laurent, Lorenz A. Fenk, Rebecca A. Butcher, Ramanujan S. Hegde, and Mario de Bono. “IL-17 Is a Neuromodulator of Caenorhabditis Elegans Sensory Responses.” <i>Nature</i>. Springer Nature, 2017. <a href=\"https://doi.org/10.1038/nature20818\">https://doi.org/10.1038/nature20818</a>.","short":"C. Chen, E. Itakura, G.M. Nelson, M. Sheng, P. Laurent, L.A. Fenk, R.A. Butcher, R.S. Hegde, M. de Bono, Nature 542 (2017) 43–48.","apa":"Chen, C., Itakura, E., Nelson, G. M., Sheng, M., Laurent, P., Fenk, L. A., … de Bono, M. (2017). IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/nature20818\">https://doi.org/10.1038/nature20818</a>","ieee":"C. Chen <i>et al.</i>, “IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses,” <i>Nature</i>, vol. 542, no. 7639. Springer Nature, pp. 43–48, 2017."},"day":"02","extern":"1","abstract":[{"lang":"eng","text":"Interleukin-17 (IL-17) is a major pro-inflammatory cytokine: it mediates responses to pathogens or tissue damage, and drives autoimmune diseases. Little is known about its role in the nervous system. Here we show that IL-17 has neuromodulator-like properties in Caenorhabditis elegans. IL-17 can act directly on neurons to alter their response properties and contribution to behaviour. Using unbiased genetic screens, we delineate an IL-17 signalling pathway and show that it acts in the RMG hub interneurons. Disrupting IL-17 signalling reduces RMG responsiveness to input from oxygen sensors, and renders sustained escape from 21% oxygen transient and contingent on additional stimuli. Over-activating IL-17 receptors abnormally heightens responses to 21% oxygen in RMG neurons and whole animals. IL-17 deficiency can be bypassed by optogenetic stimulation of RMG. Inducing IL-17 expression in adults can rescue mutant defects within 6 h. These findings reveal a non-immunological role of IL-17 modulating circuit function and behaviour."}],"publication_identifier":{"issn":["0028-0836","1476-4687"]},"publication_status":"published","language":[{"iso":"eng"}],"_id":"6117","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","external_id":{"pmid":["    28099418"]},"doi":"10.1038/nature20818","pmid":1,"oa_version":"Submitted Version","type":"journal_article","year":"2017"},{"oa_version":"Published Version","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"publist_id":"7191","doi":"10.1038/s41467-017-01683-1","pubrep_id":"911","type":"journal_article","year":"2017","scopus_import":1,"file_date_updated":"2020-07-14T12:47:20Z","publication_identifier":{"issn":["20411723"]},"acknowledgement":"We are grateful to M. Lang, H. Janovjak, M. Khammash, A. Milias-Argeitis, M. Rullan, G. Batt, A. Bosma-Moody, Aryan, S. Leibler, and members of the Guet and Tkačik groups for helpful discussion, comments, and suggestions. We thank A. Moglich, T. Mathes, J. Tabor, and S. Schmidl for kind gifts of strains, and R. Hauschild, B. Knep, M. Lang, T. Asenov, E. Papusheva, T. Menner, T. Adletzberger, and J. Merrin for technical assistance. The research leading to these results has received funding from the People Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme (FP7/2007–2013) under REA grant agreement no. [291734]. (to R.C. and J.R.), Austrian Science Fund grant FWF P28844 (to G.T.), and internal IST Austria Interdisciplinary Project Support. J.R. acknowledges support from the Agence Nationale de la Recherche (ANR) under Grant Nos. ANR-16-CE33-0018 (MEMIP), ANR-16-CE12-0025 (COGEX) and ANR-10-BINF-06-01 (ICEBERG).","article_processing_charge":"Yes (in subscription journal)","abstract":[{"lang":"eng","text":"Bacteria in groups vary individually, and interact with other bacteria and the environment to produce population-level patterns of gene expression. Investigating such behavior in detail requires measuring and controlling populations at the single-cell level alongside precisely specified interactions and environmental characteristics. Here we present an automated, programmable platform that combines image-based gene expression and growth measurements with on-line optogenetic expression control for hundreds of individual Escherichia coli cells over days, in a dynamically adjustable environment. This integrated platform broadly enables experiments that bridge individual and population behaviors. We demonstrate: (i) population structuring by independent closed-loop control of gene expression in many individual cells, (ii) cell-cell variation control during antibiotic perturbation, (iii) hybrid bio-digital circuits in single cells, and freely specifiable digital communication between individual bacteria. These examples showcase the potential for real-time integration of theoretical models with measurement and control of many individual cells to investigate and engineer microbial population behavior."}],"ec_funded":1,"project":[{"name":"International IST Postdoc Fellowship Programme","_id":"25681D80-B435-11E9-9278-68D0E5697425","grant_number":"291734","call_identifier":"FP7"},{"_id":"254E9036-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","grant_number":"P28844-B27","name":"Biophysics of information processing in gene regulation"}],"user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"CaGu"},{"_id":"GaTk"}],"_id":"613","language":[{"iso":"eng"}],"ddc":["576","579"],"publication_status":"published","date_published":"2017-12-01T00:00:00Z","date_created":"2018-12-11T11:47:30Z","month":"12","has_accepted_license":"1","volume":8,"citation":{"short":"R.P. Chait, J. Ruess, T. Bergmiller, G. Tkačik, C.C. Guet, Nature Communications 8 (2017).","apa":"Chait, R. P., Ruess, J., Bergmiller, T., Tkačik, G., &#38; Guet, C. C. (2017). Shaping bacterial population behavior through computer interfaced control of individual cells. <i>Nature Communications</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/s41467-017-01683-1\">https://doi.org/10.1038/s41467-017-01683-1</a>","ieee":"R. P. Chait, J. Ruess, T. Bergmiller, G. Tkačik, and C. C. Guet, “Shaping bacterial population behavior through computer interfaced control of individual cells,” <i>Nature Communications</i>, vol. 8, no. 1. Nature Publishing Group, 2017.","ista":"Chait RP, Ruess J, Bergmiller T, Tkačik G, Guet CC. 2017. Shaping bacterial population behavior through computer interfaced control of individual cells. Nature Communications. 8(1), 1535.","ama":"Chait RP, Ruess J, Bergmiller T, Tkačik G, Guet CC. Shaping bacterial population behavior through computer interfaced control of individual cells. <i>Nature Communications</i>. 2017;8(1). doi:<a href=\"https://doi.org/10.1038/s41467-017-01683-1\">10.1038/s41467-017-01683-1</a>","mla":"Chait, Remy P., et al. “Shaping Bacterial Population Behavior through Computer Interfaced Control of Individual Cells.” <i>Nature Communications</i>, vol. 8, no. 1, 1535, Nature Publishing Group, 2017, doi:<a href=\"https://doi.org/10.1038/s41467-017-01683-1\">10.1038/s41467-017-01683-1</a>.","chicago":"Chait, Remy P, Jakob Ruess, Tobias Bergmiller, Gašper Tkačik, and Calin C Guet. “Shaping Bacterial Population Behavior through Computer Interfaced Control of Individual Cells.” <i>Nature Communications</i>. Nature Publishing Group, 2017. <a href=\"https://doi.org/10.1038/s41467-017-01683-1\">https://doi.org/10.1038/s41467-017-01683-1</a>."},"day":"01","file":[{"date_created":"2018-12-12T10:16:05Z","creator":"system","relation":"main_file","file_id":"5190","file_size":1951699,"access_level":"open_access","content_type":"application/pdf","file_name":"IST-2017-911-v1+1_s41467-017-01683-1.pdf","date_updated":"2020-07-14T12:47:20Z","checksum":"44bb5d0229926c23a9955d9fe0f9723f"}],"date_updated":"2021-01-12T08:06:15Z","oa":1,"author":[{"id":"3464AE84-F248-11E8-B48F-1D18A9856A87","full_name":"Chait, Remy P","last_name":"Chait","orcid":"0000-0003-0876-3187","first_name":"Remy P"},{"first_name":"Jakob","orcid":"0000-0003-1615-3282","last_name":"Ruess","full_name":"Ruess, Jakob","id":"4A245D00-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0001-5396-4346","last_name":"Bergmiller","first_name":"Tobias","full_name":"Bergmiller, Tobias","id":"2C471CFA-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Tkacik","orcid":"0000-0002-6699-1455","first_name":"Gasper","id":"3D494DCA-F248-11E8-B48F-1D18A9856A87","full_name":"Tkacik, Gasper"},{"first_name":"Calin C","last_name":"Guet","orcid":"0000-0001-6220-2052","full_name":"Guet, Calin C","id":"47F8433E-F248-11E8-B48F-1D18A9856A87"}],"title":"Shaping bacterial population behavior through computer interfaced control of individual cells","article_number":"1535","status":"public","quality_controlled":"1","publisher":"Nature Publishing Group","publication":"Nature Communications","intvolume":"         8","issue":"1"},{"publication_status":"published","ddc":["570","576"],"_id":"614","language":[{"iso":"eng"}],"department":[{"_id":"BeVi"},{"_id":"NiBa"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","external_id":{"pmid":["29133797"]},"project":[{"name":"Sex chromosome evolution under male- and female- heterogamety","call_identifier":"FWF","grant_number":"P28842-B22","_id":"250ED89C-B435-11E9-9278-68D0E5697425"}],"abstract":[{"text":"Moths and butterflies (Lepidoptera) usually have a pair of differentiated WZ sex chromosomes. However, in most lineages outside of the division Ditrysia, as well as in the sister order Trichoptera, females lack a W chromosome. The W is therefore thought to have been acquired secondarily. Here we compare the genomes of three Lepidoptera species (one Dytrisia and two non-Dytrisia) to test three models accounting for the origin of the W: (1) a Z-autosome fusion; (2) a sex chromosome turnover; and (3) a non-canonical mechanism (e.g., through the recruitment of a B chromosome). We show that the gene content of the Z is highly conserved across Lepidoptera (rejecting a sex chromosome turnover) and that very few genes moved onto the Z in the common ancestor of the Ditrysia (arguing against a Z-autosome fusion). Our comparative genomics analysis therefore supports the secondary acquisition of the Lepidoptera W by a non-canonical mechanism, and it confirms the extreme stability of well-differentiated sex chromosomes.","lang":"eng"}],"article_processing_charge":"No","publication_identifier":{"issn":["20411723"]},"file_date_updated":"2020-07-14T12:47:20Z","scopus_import":1,"type":"journal_article","year":"2017","pubrep_id":"910","publist_id":"7190","doi":"10.1038/s41467-017-01663-5","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"pmid":1,"oa_version":"Published Version","issue":"1","intvolume":"         8","publication":"Nature Communications","publisher":"Nature Publishing Group","quality_controlled":"1","status":"public","article_number":"1486","title":"The deep conservation of the Lepidoptera Z chromosome suggests a non canonical origin of the W","author":[{"last_name":"Fraisse","orcid":"0000-0001-8441-5075","first_name":"Christelle","full_name":"Fraisse, Christelle","id":"32DF5794-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Picard, Marion A","id":"2C921A7A-F248-11E8-B48F-1D18A9856A87","first_name":"Marion A","orcid":"0000-0002-8101-2518","last_name":"Picard"},{"orcid":"0000-0002-4579-8306","last_name":"Vicoso","first_name":"Beatriz","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","full_name":"Vicoso, Beatriz"}],"oa":1,"related_material":{"record":[{"status":"public","relation":"popular_science","id":"7163"}]},"date_updated":"2024-02-21T13:47:47Z","file":[{"access_level":"open_access","content_type":"application/pdf","date_created":"2020-03-03T15:55:50Z","file_size":1201520,"creator":"dernst","relation":"main_file","file_id":"7562","checksum":"4da2651303c8afc2f7fc419be42a2433","file_name":"2017_NatureComm_Fraisse.pdf","date_updated":"2020-07-14T12:47:20Z"}],"day":"01","citation":{"mla":"Fraisse, Christelle, et al. “The Deep Conservation of the Lepidoptera Z Chromosome Suggests a Non Canonical Origin of the W.” <i>Nature Communications</i>, vol. 8, no. 1, 1486, Nature Publishing Group, 2017, doi:<a href=\"https://doi.org/10.1038/s41467-017-01663-5\">10.1038/s41467-017-01663-5</a>.","ama":"Fraisse C, Picard MAL, Vicoso B. The deep conservation of the Lepidoptera Z chromosome suggests a non canonical origin of the W. <i>Nature Communications</i>. 2017;8(1). doi:<a href=\"https://doi.org/10.1038/s41467-017-01663-5\">10.1038/s41467-017-01663-5</a>","ista":"Fraisse C, Picard MAL, Vicoso B. 2017. The deep conservation of the Lepidoptera Z chromosome suggests a non canonical origin of the W. Nature Communications. 8(1), 1486.","chicago":"Fraisse, Christelle, Marion A L Picard, and Beatriz Vicoso. “The Deep Conservation of the Lepidoptera Z Chromosome Suggests a Non Canonical Origin of the W.” <i>Nature Communications</i>. Nature Publishing Group, 2017. <a href=\"https://doi.org/10.1038/s41467-017-01663-5\">https://doi.org/10.1038/s41467-017-01663-5</a>.","ieee":"C. Fraisse, M. A. L. Picard, and B. Vicoso, “The deep conservation of the Lepidoptera Z chromosome suggests a non canonical origin of the W,” <i>Nature Communications</i>, vol. 8, no. 1. Nature Publishing Group, 2017.","short":"C. Fraisse, M.A.L. Picard, B. Vicoso, Nature Communications 8 (2017).","apa":"Fraisse, C., Picard, M. A. L., &#38; Vicoso, B. (2017). The deep conservation of the Lepidoptera Z chromosome suggests a non canonical origin of the W. <i>Nature Communications</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/s41467-017-01663-5\">https://doi.org/10.1038/s41467-017-01663-5</a>"},"article_type":"original","volume":8,"has_accepted_license":"1","month":"12","date_published":"2017-12-01T00:00:00Z","date_created":"2018-12-11T11:47:30Z"},{"user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"LaEr"}],"project":[{"name":"Random matrices, universality and disordered quantum systems","call_identifier":"FP7","grant_number":"338804","_id":"258DCDE6-B435-11E9-9278-68D0E5697425"}],"_id":"615","language":[{"iso":"eng"}],"publication_status":"published","publication_identifier":{"issn":["02460203"]},"ec_funded":1,"abstract":[{"text":"We show that the Dyson Brownian Motion exhibits local universality after a very short time assuming that local rigidity and level repulsion of the eigenvalues hold. These conditions are verified, hence bulk spectral universality is proven, for a large class of Wigner-like matrices, including deformed Wigner ensembles and ensembles with non-stochastic variance matrices whose limiting densities differ from Wigner's semicircle law.","lang":"eng"}],"type":"journal_article","year":"2017","scopus_import":1,"oa_version":"Submitted Version","publist_id":"7189","doi":"10.1214/16-AIHP765","publication":"Annales de l'institut Henri Poincare (B) Probability and Statistics","intvolume":"        53","page":"1606 - 1656","quality_controlled":"1","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1504.00650"}],"publisher":"Institute of Mathematical Statistics","issue":"4","author":[{"id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","full_name":"Erdös, László","first_name":"László","orcid":"0000-0001-5366-9603","last_name":"Erdös"},{"first_name":"Kevin","last_name":"Schnelli","orcid":"0000-0003-0954-3231","id":"434AD0AE-F248-11E8-B48F-1D18A9856A87","full_name":"Schnelli, Kevin"}],"oa":1,"status":"public","title":"Universality for random matrix flows with time dependent density","date_updated":"2021-01-12T08:06:22Z","day":"01","citation":{"apa":"Erdös, L., &#38; Schnelli, K. (2017). Universality for random matrix flows with time dependent density. <i>Annales de l’institut Henri Poincare (B) Probability and Statistics</i>. Institute of Mathematical Statistics. <a href=\"https://doi.org/10.1214/16-AIHP765\">https://doi.org/10.1214/16-AIHP765</a>","short":"L. Erdös, K. Schnelli, Annales de l’institut Henri Poincare (B) Probability and Statistics 53 (2017) 1606–1656.","ieee":"L. Erdös and K. Schnelli, “Universality for random matrix flows with time dependent density,” <i>Annales de l’institut Henri Poincare (B) Probability and Statistics</i>, vol. 53, no. 4. Institute of Mathematical Statistics, pp. 1606–1656, 2017.","chicago":"Erdös, László, and Kevin Schnelli. “Universality for Random Matrix Flows with Time Dependent Density.” <i>Annales de l’institut Henri Poincare (B) Probability and Statistics</i>. Institute of Mathematical Statistics, 2017. <a href=\"https://doi.org/10.1214/16-AIHP765\">https://doi.org/10.1214/16-AIHP765</a>.","ista":"Erdös L, Schnelli K. 2017. Universality for random matrix flows with time dependent density. Annales de l’institut Henri Poincare (B) Probability and Statistics. 53(4), 1606–1656.","ama":"Erdös L, Schnelli K. Universality for random matrix flows with time dependent density. <i>Annales de l’institut Henri Poincare (B) Probability and Statistics</i>. 2017;53(4):1606-1656. doi:<a href=\"https://doi.org/10.1214/16-AIHP765\">10.1214/16-AIHP765</a>","mla":"Erdös, László, and Kevin Schnelli. “Universality for Random Matrix Flows with Time Dependent Density.” <i>Annales de l’institut Henri Poincare (B) Probability and Statistics</i>, vol. 53, no. 4, Institute of Mathematical Statistics, 2017, pp. 1606–56, doi:<a href=\"https://doi.org/10.1214/16-AIHP765\">10.1214/16-AIHP765</a>."},"month":"11","date_published":"2017-11-01T00:00:00Z","date_created":"2018-12-11T11:47:30Z","volume":53},{"abstract":[{"lang":"eng","text":"Background: Increasing temperatures are predicted to strongly impact host-parasite interactions, but empirical tests are rare. Host species that are naturally exposed to a broad temperature spectrum offer the possibility to investigate the effects of elevated temperatures on hosts and parasites. Using three-spined sticklebacks, Gasterosteus aculeatus L., and tapeworms, Schistocephalus solidus (Müller, 1776), originating from a cold and a warm water site of a volcanic lake, we subjected sympatric and allopatric host-parasite combinations to cold and warm conditions in a fully crossed design. We predicted that warm temperatures would promote the development of the parasites, while the hosts might benefit from cooler temperatures. We further expected adaptations to the local temperature and mutual adaptations of local host-parasite pairs. Results: Overall, S. solidus parasites grew faster at warm temperatures and stickleback hosts at cold temperatures. On a finer scale, we observed that parasites were able to exploit their hosts more efficiently at the parasite’s temperature of origin. In contrast, host tolerance towards parasite infection was higher when sticklebacks were infected with parasites at the parasite’s ‘foreign’ temperature. Cold-origin sticklebacks tended to grow faster and parasite infection induced a stronger immune response. Conclusions: Our results suggest that increasing environmental temperatures promote the parasite rather than the host and that host tolerance is dependent on the interaction between parasite infection and temperature. Sticklebacks might use tolerance mechanisms towards parasite infection in combination with their high plasticity towards temperature changes to cope with increasing parasite infection pressures and rising temperatures."}],"extern":"1","file_date_updated":"2020-07-14T12:47:22Z","publication_identifier":{"issn":["17563305"]},"_id":"618","language":[{"iso":"eng"}],"publication_status":"published","ddc":["570"],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"doi":"10.1186/s13071-017-2192-7","publist_id":"7186","oa_version":"Published Version","year":"2017","type":"journal_article","title":"Environmental temperature variation influences fitness trade-offs in a fish-tapeworm association ","article_number":"52","status":"public","oa":1,"author":[{"full_name":"Franke, Frederik","first_name":"Frederik","last_name":"Franke"},{"first_name":"Sophie","last_name":"Armitage","full_name":"Armitage, Sophie"},{"orcid":"0000-0002-8696-6978","last_name":"Kutzer","first_name":"Megan","id":"29D0B332-F248-11E8-B48F-1D18A9856A87","full_name":"Kutzer, Megan"},{"full_name":"Kurtz, Joachim","last_name":"Kurtz","first_name":"Joachim"},{"full_name":"Scharsack, Jörn","last_name":"Scharsack","first_name":"Jörn"}],"issue":"252","quality_controlled":"1","publisher":"BioMed Central","publication":"Parasites & Vectors","intvolume":"        10","has_accepted_license":"1","volume":10,"date_created":"2018-12-11T11:47:31Z","date_published":"2017-06-02T00:00:00Z","month":"06","day":"02","citation":{"short":"F. Franke, S. Armitage, M. Kutzer, J. Kurtz, J. Scharsack, Parasites &#38; Vectors 10 (2017).","apa":"Franke, F., Armitage, S., Kutzer, M., Kurtz, J., &#38; Scharsack, J. (2017). Environmental temperature variation influences fitness trade-offs in a fish-tapeworm association . <i>Parasites &#38; Vectors</i>. BioMed Central. <a href=\"https://doi.org/10.1186/s13071-017-2192-7\">https://doi.org/10.1186/s13071-017-2192-7</a>","ieee":"F. Franke, S. Armitage, M. Kutzer, J. Kurtz, and J. Scharsack, “Environmental temperature variation influences fitness trade-offs in a fish-tapeworm association ,” <i>Parasites &#38; Vectors</i>, vol. 10, no. 252. BioMed Central, 2017.","ista":"Franke F, Armitage S, Kutzer M, Kurtz J, Scharsack J. 2017. Environmental temperature variation influences fitness trade-offs in a fish-tapeworm association . Parasites &#38; Vectors. 10(252), 52.","ama":"Franke F, Armitage S, Kutzer M, Kurtz J, Scharsack J. Environmental temperature variation influences fitness trade-offs in a fish-tapeworm association . <i>Parasites &#38; Vectors</i>. 2017;10(252). doi:<a href=\"https://doi.org/10.1186/s13071-017-2192-7\">10.1186/s13071-017-2192-7</a>","mla":"Franke, Frederik, et al. “Environmental Temperature Variation Influences Fitness Trade-Offs in a Fish-Tapeworm Association .” <i>Parasites &#38; Vectors</i>, vol. 10, no. 252, 52, BioMed Central, 2017, doi:<a href=\"https://doi.org/10.1186/s13071-017-2192-7\">10.1186/s13071-017-2192-7</a>.","chicago":"Franke, Frederik, Sophie Armitage, Megan Kutzer, Joachim Kurtz, and Jörn Scharsack. “Environmental Temperature Variation Influences Fitness Trade-Offs in a Fish-Tapeworm Association .” <i>Parasites &#38; Vectors</i>. BioMed Central, 2017. <a href=\"https://doi.org/10.1186/s13071-017-2192-7\">https://doi.org/10.1186/s13071-017-2192-7</a>."},"file":[{"file_size":671807,"creator":"dernst","file_id":"5864","relation":"main_file","date_created":"2019-01-21T13:45:36Z","content_type":"application/pdf","access_level":"open_access","date_updated":"2020-07-14T12:47:22Z","file_name":"2017_Parasites_Franke.pdf","checksum":"742943377a38ee208108705b8e2f4dbf"}],"date_updated":"2021-01-12T08:06:35Z"},{"year":"2017","type":"journal_article","oa_version":"Published Version","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"doi":"10.13154/TOSC.V2016.I2.145-161","project":[{"call_identifier":"H2020","grant_number":"682815","_id":"258AA5B2-B435-11E9-9278-68D0E5697425","name":"Teaching Old Crypto New Tricks"}],"user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"KrPi"}],"language":[{"iso":"eng"}],"_id":"6196","ddc":["000"],"publication_status":"published","file_date_updated":"2020-07-14T12:47:24Z","publication_identifier":{"eissn":["2519-173X"]},"abstract":[{"text":"PMAC is a simple and parallel block-cipher mode of operation, which was introduced by Black and Rogaway at Eurocrypt 2002. If instantiated with a (pseudo)random permutation over n-bit strings, PMAC constitutes a provably secure variable input-length (pseudo)random function. For adversaries making q queries, each of length at most l (in n-bit blocks), and of total length σ ≤ ql, the original paper proves an upper bound on the distinguishing advantage of  Ο(σ2/2n), while the currently best bound is  Ο (qσ/2n).In this work we show that this bound is tight by giving an attack with advantage Ω (q2l/2n). In the PMAC construction one initially XORs a mask to every message block, where the mask for the ith block is computed as τi := γi·L, where L is a (secret) random value, and γi is the i-th codeword of the Gray code. Our attack applies more generally to any sequence of γi’s which contains a large coset of a subgroup of GF(2n). We then investigate if the security of PMAC can be further improved by using τi’s that are k-wise independent, for k > 1 (the original distribution is only 1-wise independent). We observe that the security of PMAC will not increase in general, even if the masks are chosen from a 2-wise independent distribution, and then prove that the security increases to O(q<2/2n), if the τi are 4-wise independent. Due to simple extension attacks, this is the best bound one can hope for, using any distribution on the masks. Whether 3-wise independence is already sufficient to get this level of security is left as an open problem.","lang":"eng"}],"ec_funded":1,"day":"03","citation":{"ieee":"P. Gazi, K. Z. Pietrzak, and M. Rybar, “The exact security of PMAC,” <i>IACR Transactions on Symmetric Cryptology</i>, vol. 2016, no. 2. Ruhr University Bochum, pp. 145–161, 2017.","short":"P. Gazi, K.Z. Pietrzak, M. Rybar, IACR Transactions on Symmetric Cryptology 2016 (2017) 145–161.","apa":"Gazi, P., Pietrzak, K. Z., &#38; Rybar, M. (2017). The exact security of PMAC. <i>IACR Transactions on Symmetric Cryptology</i>. Ruhr University Bochum. <a href=\"https://doi.org/10.13154/TOSC.V2016.I2.145-161\">https://doi.org/10.13154/TOSC.V2016.I2.145-161</a>","mla":"Gazi, Peter, et al. “The Exact Security of PMAC.” <i>IACR Transactions on Symmetric Cryptology</i>, vol. 2016, no. 2, Ruhr University Bochum, 2017, pp. 145–61, doi:<a href=\"https://doi.org/10.13154/TOSC.V2016.I2.145-161\">10.13154/TOSC.V2016.I2.145-161</a>.","ama":"Gazi P, Pietrzak KZ, Rybar M. The exact security of PMAC. <i>IACR Transactions on Symmetric Cryptology</i>. 2017;2016(2):145-161. doi:<a href=\"https://doi.org/10.13154/TOSC.V2016.I2.145-161\">10.13154/TOSC.V2016.I2.145-161</a>","ista":"Gazi P, Pietrzak KZ, Rybar M. 2017. The exact security of PMAC. IACR Transactions on Symmetric Cryptology. 2016(2), 145–161.","chicago":"Gazi, Peter, Krzysztof Z Pietrzak, and Michal Rybar. “The Exact Security of PMAC.” <i>IACR Transactions on Symmetric Cryptology</i>. Ruhr University Bochum, 2017. <a href=\"https://doi.org/10.13154/TOSC.V2016.I2.145-161\">https://doi.org/10.13154/TOSC.V2016.I2.145-161</a>."},"file":[{"date_updated":"2020-07-14T12:47:24Z","file_name":"2017_IACR_Gazi.pdf","checksum":"f23161d685dd957ae8d7274132999684","file_id":"6197","creator":"dernst","relation":"main_file","file_size":597335,"date_created":"2019-04-04T13:53:58Z","content_type":"application/pdf","access_level":"open_access"}],"date_updated":"2023-09-07T12:02:27Z","related_material":{"record":[{"status":"public","id":"838","relation":"dissertation_contains"}]},"date_published":"2017-02-03T00:00:00Z","date_created":"2019-04-04T13:48:23Z","month":"02","has_accepted_license":"1","volume":2016,"quality_controlled":"1","page":"145-161","publisher":"Ruhr University Bochum","publication":"IACR Transactions on Symmetric Cryptology","intvolume":"      2016","issue":"2","oa":1,"author":[{"first_name":"Peter","last_name":"Gazi","full_name":"Gazi, Peter","id":"3E0BFE38-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Krzysztof Z","last_name":"Pietrzak","orcid":"0000-0002-9139-1654","id":"3E04A7AA-F248-11E8-B48F-1D18A9856A87","full_name":"Pietrzak, Krzysztof Z"},{"full_name":"Rybar, Michal","id":"2B3E3DE8-F248-11E8-B48F-1D18A9856A87","first_name":"Michal","last_name":"Rybar"}],"title":"The exact security of PMAC","status":"public"},{"issue":"24","publication":"FEBS letters","intvolume":"       591","page":"3993  - 4008","quality_controlled":"1","publisher":"Wiley-Blackwell","status":"public","title":"Mechanisms of radial glia progenitor cell lineage progression","author":[{"first_name":"Robert J","last_name":"Beattie","orcid":"0000-0002-8483-8753","full_name":"Beattie, Robert J","id":"2E26DF60-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Simon","last_name":"Hippenmeyer","orcid":"0000-0003-2279-1061","id":"37B36620-F248-11E8-B48F-1D18A9856A87","full_name":"Hippenmeyer, Simon"}],"oa":1,"date_updated":"2024-02-14T12:02:08Z","citation":{"ieee":"R. J. Beattie and S. Hippenmeyer, “Mechanisms of radial glia progenitor cell lineage progression,” <i>FEBS letters</i>, vol. 591, no. 24. Wiley-Blackwell, pp. 3993–4008, 2017.","apa":"Beattie, R. J., &#38; Hippenmeyer, S. (2017). Mechanisms of radial glia progenitor cell lineage progression. <i>FEBS Letters</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1002/1873-3468.12906\">https://doi.org/10.1002/1873-3468.12906</a>","short":"R.J. Beattie, S. Hippenmeyer, FEBS Letters 591 (2017) 3993–4008.","chicago":"Beattie, Robert J, and Simon Hippenmeyer. “Mechanisms of Radial Glia Progenitor Cell Lineage Progression.” <i>FEBS Letters</i>. Wiley-Blackwell, 2017. <a href=\"https://doi.org/10.1002/1873-3468.12906\">https://doi.org/10.1002/1873-3468.12906</a>.","mla":"Beattie, Robert J., and Simon Hippenmeyer. “Mechanisms of Radial Glia Progenitor Cell Lineage Progression.” <i>FEBS Letters</i>, vol. 591, no. 24, Wiley-Blackwell, 2017, pp. 3993–4008, doi:<a href=\"https://doi.org/10.1002/1873-3468.12906\">10.1002/1873-3468.12906</a>.","ama":"Beattie RJ, Hippenmeyer S. Mechanisms of radial glia progenitor cell lineage progression. <i>FEBS letters</i>. 2017;591(24):3993-4008. doi:<a href=\"https://doi.org/10.1002/1873-3468.12906\">10.1002/1873-3468.12906</a>","ista":"Beattie RJ, Hippenmeyer S. 2017. Mechanisms of radial glia progenitor cell lineage progression. FEBS letters. 591(24), 3993–4008."},"day":"01","file":[{"checksum":"a46dadc84e0c28d389dd3e9e954464db","date_updated":"2020-07-14T12:47:24Z","file_name":"IST-2018-928-v1+1_Beattie_et_al-2017-FEBS_Letters.pdf","content_type":"application/pdf","access_level":"open_access","creator":"system","file_id":"5211","relation":"main_file","file_size":644149,"date_created":"2018-12-12T10:16:24Z"}],"volume":591,"has_accepted_license":"1","month":"12","date_published":"2017-12-01T00:00:00Z","date_created":"2018-12-11T11:47:32Z","_id":"621","language":[{"iso":"eng"}],"publication_status":"published","ddc":["571","610"],"department":[{"_id":"SiHi"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","project":[{"_id":"25D7962E-B435-11E9-9278-68D0E5697425","grant_number":"RGP0053/2014","name":"Quantitative Structure-Function Analysis of Cerebral Cortex Assembly at Clonal Level"},{"name":"Molecular Mechanisms of Cerebral Cortex Development","_id":"25D61E48-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","grant_number":"618444"}],"external_id":{"pmid":["29121403"]},"ec_funded":1,"abstract":[{"lang":"eng","text":"The mammalian cerebral cortex is responsible for higher cognitive functions such as perception, consciousness, and acquiring and processing information. The neocortex is organized into six distinct laminae, each composed of a rich diversity of cell types which assemble into highly complex cortical circuits. Radial glia progenitors (RGPs) are responsible for producing all neocortical neurons and certain glia lineages. Here, we discuss recent discoveries emerging from clonal lineage analysis at the single RGP cell level that provide us with an inaugural quantitative framework of RGP lineage progression. We further discuss the importance of the relative contribution of intrinsic gene functions and non-cell-autonomous or community effects in regulating RGP proliferation behavior and lineage progression."}],"article_processing_charge":"Yes (in subscription journal)","file_date_updated":"2020-07-14T12:47:24Z","publication_identifier":{"issn":["00145793"]},"type":"journal_article","year":"2017","scopus_import":"1","pubrep_id":"928","doi":"10.1002/1873-3468.12906","publist_id":"7183","tmp":{"name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","short":"CC BY-NC (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","image":"/images/cc_by_nc.png"},"pmid":1,"oa_version":"Published Version"},{"oa_version":"None","doi":"10.1007/978-3-319-52498-6_9","publist_id":"7177","year":"2017","type":"book_chapter","scopus_import":1,"alternative_title":["ADVSANAT"],"publication_identifier":{"issn":["03015556"],"isbn":["978-3-319-52496-2"]},"abstract":[{"text":"Genetic factors might be largely responsible for the development of autism spectrum disorder (ASD) that alone or in combination with specific environmental risk factors trigger the pathology. Multiple mutations identified in ASD patients that impair synaptic function in the central nervous system are well studied in animal models. How these mutations might interact with other risk factors is not fully understood though. Additionally, how systems outside of the brain are altered in the context of ASD is an emerging area of research. Extracerebral influences on the physiology could begin in utero and contribute to changes in the brain and in the development of other body systems and further lead to epigenetic changes. Therefore, multiple recent studies have aimed at elucidating the role of gene-environment interactions in ASD. Here we provide an overview on the extracerebral systems that might play an important associative role in ASD and review evidence regarding the potential roles of inflammation, trace metals, metabolism, genetic susceptibility, enteric nervous system function and the microbiota of the gastrointestinal (GI) tract on the development of endophenotypes in animal models of ASD. By influencing environmental conditions, it might be possible to reduce or limit the severity of ASD pathology.","lang":"eng"}],"series_title":"Advances in Anatomy Embryology and Cell Biology","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"GaNo"}],"_id":"623","language":[{"iso":"eng"}],"publication_status":"published","month":"05","date_created":"2018-12-11T11:47:33Z","date_published":"2017-05-28T00:00:00Z","volume":224,"date_updated":"2021-01-12T08:06:46Z","editor":[{"last_name":"Schmeisser","first_name":"Michael","full_name":"Schmeisser, Michael"},{"first_name":"Tobias","last_name":"Boekers","full_name":"Boekers, Tobias"}],"day":"28","citation":{"ieee":"E. Hill Yardin, S. Mckeown, G. Novarino, and A. Grabrucker, “Extracerebral dysfunction in animal models of autism spectrum disorder,” in <i>Translational Anatomy and Cell Biology of Autism Spectrum Disorder</i>, vol. 224, M. Schmeisser and T. Boekers, Eds. Springer, 2017, pp. 159–187.","short":"E. Hill Yardin, S. Mckeown, G. Novarino, A. Grabrucker, in:, M. Schmeisser, T. Boekers (Eds.), Translational Anatomy and Cell Biology of Autism Spectrum Disorder, Springer, 2017, pp. 159–187.","apa":"Hill Yardin, E., Mckeown, S., Novarino, G., &#38; Grabrucker, A. (2017). Extracerebral dysfunction in animal models of autism spectrum disorder. In M. Schmeisser &#38; T. Boekers (Eds.), <i>Translational Anatomy and Cell Biology of Autism Spectrum Disorder</i> (Vol. 224, pp. 159–187). Springer. <a href=\"https://doi.org/10.1007/978-3-319-52498-6_9\">https://doi.org/10.1007/978-3-319-52498-6_9</a>","mla":"Hill Yardin, Elisa, et al. “Extracerebral Dysfunction in Animal Models of Autism Spectrum Disorder.” <i>Translational Anatomy and Cell Biology of Autism Spectrum Disorder</i>, edited by Michael Schmeisser and Tobias Boekers, vol. 224, Springer, 2017, pp. 159–87, doi:<a href=\"https://doi.org/10.1007/978-3-319-52498-6_9\">10.1007/978-3-319-52498-6_9</a>.","ista":"Hill Yardin E, Mckeown S, Novarino G, Grabrucker A. 2017.Extracerebral dysfunction in animal models of autism spectrum disorder. In: Translational Anatomy and Cell Biology of Autism Spectrum Disorder. ADVSANAT, vol. 224, 159–187.","ama":"Hill Yardin E, Mckeown S, Novarino G, Grabrucker A. Extracerebral dysfunction in animal models of autism spectrum disorder. In: Schmeisser M, Boekers T, eds. <i>Translational Anatomy and Cell Biology of Autism Spectrum Disorder</i>. Vol 224. Advances in Anatomy Embryology and Cell Biology. Springer; 2017:159-187. doi:<a href=\"https://doi.org/10.1007/978-3-319-52498-6_9\">10.1007/978-3-319-52498-6_9</a>","chicago":"Hill Yardin, Elisa, Sonja Mckeown, Gaia Novarino, and Andreas Grabrucker. “Extracerebral Dysfunction in Animal Models of Autism Spectrum Disorder.” In <i>Translational Anatomy and Cell Biology of Autism Spectrum Disorder</i>, edited by Michael Schmeisser and Tobias Boekers, 224:159–87. Advances in Anatomy Embryology and Cell Biology. Springer, 2017. <a href=\"https://doi.org/10.1007/978-3-319-52498-6_9\">https://doi.org/10.1007/978-3-319-52498-6_9</a>."},"author":[{"first_name":"Elisa","last_name":"Hill Yardin","full_name":"Hill Yardin, Elisa"},{"first_name":"Sonja","last_name":"Mckeown","full_name":"Mckeown, Sonja"},{"full_name":"Novarino, Gaia","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","last_name":"Novarino","orcid":"0000-0002-7673-7178","first_name":"Gaia"},{"full_name":"Grabrucker, Andreas","first_name":"Andreas","last_name":"Grabrucker"}],"status":"public","title":"Extracerebral dysfunction in animal models of autism spectrum disorder","publication":"Translational Anatomy and Cell Biology of Autism Spectrum Disorder","intvolume":"       224","page":"159 - 187","quality_controlled":"1","publisher":"Springer"},{"scopus_import":1,"year":"2017","type":"journal_article","pubrep_id":"909","doi":"10.7717/peerj.3830","publist_id":"7172","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"oa_version":"Published Version","ddc":["579"],"publication_status":"published","_id":"624","language":[{"iso":"eng"}],"department":[{"_id":"CaGu"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","abstract":[{"lang":"eng","text":"Bacteria adapt to adverse environmental conditions by altering gene expression patterns. Recently, a novel stress adaptation mechanism has been described that allows Escherichia coli to alter gene expression at the post-transcriptional level. The key player in this regulatory pathway is the endoribonuclease MazF, the toxin component of the toxin-antitoxin module mazEF that is triggered by various stressful conditions. In general, MazF degrades the majority of transcripts by cleaving at ACA sites, which results in the retardation of bacterial growth. Furthermore, MazF can process a small subset of mRNAs and render them leaderless by removing their ribosome binding site. MazF concomitantly modifies ribosomes, making them selective for the translation of leaderless mRNAs. In this study, we employed fluorescent reporter-systems to investigate mazEF expression during stressful conditions, and to infer consequences of the mRNA processing mediated by MazF on gene expression at the single-cell level. Our results suggest that mazEF transcription is maintained at low levels in single cells encountering adverse conditions, such as antibiotic stress or amino acid starvation. Moreover, using the grcA mRNA as a model for MazF-mediated mRNA processing, we found that MazF activation promotes heterogeneity in the grcA reporter expression, resulting in a subpopulation of cells with increased levels of GrcA reporter protein."}],"acknowledgement":"Austrian Science Fund (FWF): M1697, P22249; Swiss National Science Foundation (SNF): 145706; European Commission;FWF Special Research Program: RNA-REG F43","publication_identifier":{"issn":["21678359"]},"file_date_updated":"2020-07-14T12:47:24Z","date_updated":"2021-01-12T08:06:48Z","file":[{"date_updated":"2020-07-14T12:47:24Z","file_name":"IST-2017-909-v1+1_peerj-3830.pdf","checksum":"3d79ae6b6eabc90b0eaaed82ff3493b0","file_size":682064,"relation":"main_file","creator":"system","file_id":"4908","date_created":"2018-12-12T10:11:51Z","content_type":"application/pdf","access_level":"open_access"}],"citation":{"mla":"Nikolic, Nela, et al. “MazF Activation Promotes Translational Heterogeneity of the GrcA MRNA in Escherichia Coli Populations.” <i>PeerJ</i>, vol. 2017, no. 9, 3830, PeerJ, 2017, doi:<a href=\"https://doi.org/10.7717/peerj.3830\">10.7717/peerj.3830</a>.","ama":"Nikolic N, Didara Z, Moll I. MazF activation promotes translational heterogeneity of the grcA mRNA in Escherichia coli populations. <i>PeerJ</i>. 2017;2017(9). doi:<a href=\"https://doi.org/10.7717/peerj.3830\">10.7717/peerj.3830</a>","ista":"Nikolic N, Didara Z, Moll I. 2017. MazF activation promotes translational heterogeneity of the grcA mRNA in Escherichia coli populations. PeerJ. 2017(9), 3830.","chicago":"Nikolic, Nela, Zrinka Didara, and Isabella Moll. “MazF Activation Promotes Translational Heterogeneity of the GrcA MRNA in Escherichia Coli Populations.” <i>PeerJ</i>. PeerJ, 2017. <a href=\"https://doi.org/10.7717/peerj.3830\">https://doi.org/10.7717/peerj.3830</a>.","ieee":"N. Nikolic, Z. Didara, and I. Moll, “MazF activation promotes translational heterogeneity of the grcA mRNA in Escherichia coli populations,” <i>PeerJ</i>, vol. 2017, no. 9. PeerJ, 2017.","short":"N. Nikolic, Z. Didara, I. Moll, PeerJ 2017 (2017).","apa":"Nikolic, N., Didara, Z., &#38; Moll, I. (2017). MazF activation promotes translational heterogeneity of the grcA mRNA in Escherichia coli populations. <i>PeerJ</i>. PeerJ. <a href=\"https://doi.org/10.7717/peerj.3830\">https://doi.org/10.7717/peerj.3830</a>"},"day":"21","volume":2017,"has_accepted_license":"1","month":"09","date_published":"2017-09-21T00:00:00Z","date_created":"2018-12-11T11:47:33Z","issue":"9","intvolume":"      2017","publication":"PeerJ","publisher":"PeerJ","quality_controlled":"1","status":"public","article_number":"3830","title":"MazF activation promotes translational heterogeneity of the grcA mRNA in Escherichia coli populations","author":[{"full_name":"Nikolic, Nela","id":"42D9CABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-9068-6090","last_name":"Nikolic","first_name":"Nela"},{"full_name":"Didara, Zrinka","first_name":"Zrinka","last_name":"Didara"},{"full_name":"Moll, Isabella","first_name":"Isabella","last_name":"Moll"}],"oa":1},{"intvolume":"     10460","publication":"Models, Algorithms, Logics and Tools","publisher":"Springer","page":"367 - 381","quality_controlled":"1","author":[{"full_name":"Chatterjee, Krishnendu","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4561-241X","last_name":"Chatterjee","first_name":"Krishnendu"},{"full_name":"Doyen, Laurent","first_name":"Laurent","last_name":"Doyen"},{"first_name":"Thomas A","orcid":"0000−0002−2985−7724","last_name":"Henzinger","id":"40876CD8-F248-11E8-B48F-1D18A9856A87","full_name":"Henzinger, Thomas A"}],"oa":1,"status":"public","title":"The cost of exactness in quantitative reachability","editor":[{"last_name":"Aceto","first_name":"Luca","full_name":"Aceto, Luca"},{"first_name":"Giorgio","last_name":"Bacci","full_name":"Bacci, Giorgio"},{"last_name":"Ingólfsdóttir","first_name":"Anna","full_name":"Ingólfsdóttir, Anna"},{"full_name":"Legay, Axel","last_name":"Legay","first_name":"Axel"},{"full_name":"Mardare, Radu","last_name":"Mardare","first_name":"Radu"}],"date_updated":"2025-06-02T08:53:45Z","file":[{"date_updated":"2020-07-14T12:47:25Z","file_name":"2017_ModelsAlgorithms_Chatterjee.pdf","checksum":"b2402766ec02c79801aac634bd8f9f6c","file_size":192826,"file_id":"7048","relation":"main_file","creator":"dernst","date_created":"2019-11-19T08:06:50Z","content_type":"application/pdf","access_level":"open_access"}],"citation":{"chicago":"Chatterjee, Krishnendu, Laurent Doyen, and Thomas A Henzinger. “The Cost of Exactness in Quantitative Reachability.” In <i>Models, Algorithms, Logics and Tools</i>, edited by Luca Aceto, Giorgio Bacci, Anna Ingólfsdóttir, Axel Legay, and Radu Mardare, 10460:367–81. Theoretical Computer Science and General Issues. Springer, 2017. <a href=\"https://doi.org/10.1007/978-3-319-63121-9_18\">https://doi.org/10.1007/978-3-319-63121-9_18</a>.","ama":"Chatterjee K, Doyen L, Henzinger TA. The cost of exactness in quantitative reachability. In: Aceto L, Bacci G, Ingólfsdóttir A, Legay A, Mardare R, eds. <i>Models, Algorithms, Logics and Tools</i>. Vol 10460. Theoretical Computer Science and General Issues. Springer; 2017:367-381. doi:<a href=\"https://doi.org/10.1007/978-3-319-63121-9_18\">10.1007/978-3-319-63121-9_18</a>","ista":"Chatterjee K, Doyen L, Henzinger TA. 2017.The cost of exactness in quantitative reachability. In: Models, Algorithms, Logics and Tools. LNCS, vol. 10460, 367–381.","mla":"Chatterjee, Krishnendu, et al. “The Cost of Exactness in Quantitative Reachability.” <i>Models, Algorithms, Logics and Tools</i>, edited by Luca Aceto et al., vol. 10460, Springer, 2017, pp. 367–81, doi:<a href=\"https://doi.org/10.1007/978-3-319-63121-9_18\">10.1007/978-3-319-63121-9_18</a>.","apa":"Chatterjee, K., Doyen, L., &#38; Henzinger, T. A. (2017). The cost of exactness in quantitative reachability. In L. Aceto, G. Bacci, A. Ingólfsdóttir, A. Legay, &#38; R. Mardare (Eds.), <i>Models, Algorithms, Logics and Tools</i> (Vol. 10460, pp. 367–381). Springer. <a href=\"https://doi.org/10.1007/978-3-319-63121-9_18\">https://doi.org/10.1007/978-3-319-63121-9_18</a>","short":"K. Chatterjee, L. Doyen, T.A. Henzinger, in:, L. Aceto, G. Bacci, A. Ingólfsdóttir, A. Legay, R. Mardare (Eds.), Models, Algorithms, Logics and Tools, Springer, 2017, pp. 367–381.","ieee":"K. Chatterjee, L. Doyen, and T. A. Henzinger, “The cost of exactness in quantitative reachability,” in <i>Models, Algorithms, Logics and Tools</i>, vol. 10460, L. Aceto, G. Bacci, A. Ingólfsdóttir, A. Legay, and R. Mardare, Eds. Springer, 2017, pp. 367–381."},"day":"25","month":"07","date_published":"2017-07-25T00:00:00Z","date_created":"2018-12-11T11:47:34Z","volume":10460,"has_accepted_license":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"KrCh"},{"_id":"ToHe"}],"series_title":"Theoretical Computer Science and General Issues","project":[{"name":"Moderne Concurrency Paradigms","call_identifier":"FWF","grant_number":"S11402-N23","_id":"25F5A88A-B435-11E9-9278-68D0E5697425"},{"_id":"25863FF4-B435-11E9-9278-68D0E5697425","grant_number":"S11407","call_identifier":"FWF","name":"Game Theory"},{"_id":"25F42A32-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","grant_number":"Z211","name":"The Wittgenstein Prize"},{"grant_number":"279307","call_identifier":"FP7","_id":"2581B60A-B435-11E9-9278-68D0E5697425","name":"Quantitative Graph Games: Theory and Applications"},{"grant_number":"ICT15-003","_id":"25892FC0-B435-11E9-9278-68D0E5697425","name":"Efficient Algorithms for Computer Aided Verification"}],"ddc":["000"],"publication_status":"published","_id":"625","language":[{"iso":"eng"}],"alternative_title":["LNCS"],"article_processing_charge":"No","acknowledgement":"This research was supported in part by the Austrian Science Fund (FWF) under grants S11402-N23 and S11407-N23 (RiSE/SHiNE), and Z211-N23 (Wittgenstein Award), ERC Start grant (279307: Graph Games), Vienna Science and Technology Fund (WWTF) through project ICT15-003.","publication_identifier":{"issn":["0302-9743"],"isbn":["978-3-319-63120-2"]},"file_date_updated":"2020-07-14T12:47:25Z","ec_funded":1,"abstract":[{"text":"In the analysis of reactive systems a quantitative objective assigns a real value to every trace of the system. The value decision problem for a quantitative objective requires a trace whose value is at least a given threshold, and the exact value decision problem requires a trace whose value is exactly the threshold. We compare the computational complexity of the value and exact value decision problems for classical quantitative objectives, such as sum, discounted sum, energy, and mean-payoff for two standard models of reactive systems, namely, graphs and graph games.","lang":"eng"}],"scopus_import":"1","year":"2017","type":"book_chapter","oa_version":"Submitted Version","publist_id":"7170","doi":"10.1007/978-3-319-63121-9_18"},{"title":"The infinitesimal model: Definition derivation and implications","status":"public","oa":1,"author":[{"full_name":"Barton, Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","first_name":"Nicholas H","orcid":"0000-0002-8548-5240","last_name":"Barton"},{"first_name":"Alison","last_name":"Etheridge","full_name":"Etheridge, Alison"},{"last_name":"Véber","first_name":"Amandine","full_name":"Véber, Amandine"}],"page":"50 - 73","quality_controlled":"1","publisher":"Academic Press","publication":"Theoretical Population Biology","intvolume":"       118","has_accepted_license":"1","volume":118,"date_published":"2017-12-01T00:00:00Z","date_created":"2018-12-11T11:47:34Z","month":"12","citation":{"mla":"Barton, Nicholas H., et al. “The Infinitesimal Model: Definition Derivation and Implications.” <i>Theoretical Population Biology</i>, vol. 118, Academic Press, 2017, pp. 50–73, doi:<a href=\"https://doi.org/10.1016/j.tpb.2017.06.001\">10.1016/j.tpb.2017.06.001</a>.","ista":"Barton NH, Etheridge A, Véber A. 2017. The infinitesimal model: Definition derivation and implications. Theoretical Population Biology. 118, 50–73.","ama":"Barton NH, Etheridge A, Véber A. The infinitesimal model: Definition derivation and implications. <i>Theoretical Population Biology</i>. 2017;118:50-73. doi:<a href=\"https://doi.org/10.1016/j.tpb.2017.06.001\">10.1016/j.tpb.2017.06.001</a>","chicago":"Barton, Nicholas H, Alison Etheridge, and Amandine Véber. “The Infinitesimal Model: Definition Derivation and Implications.” <i>Theoretical Population Biology</i>. Academic Press, 2017. <a href=\"https://doi.org/10.1016/j.tpb.2017.06.001\">https://doi.org/10.1016/j.tpb.2017.06.001</a>.","ieee":"N. H. Barton, A. Etheridge, and A. Véber, “The infinitesimal model: Definition derivation and implications,” <i>Theoretical Population Biology</i>, vol. 118. Academic Press, pp. 50–73, 2017.","short":"N.H. Barton, A. Etheridge, A. Véber, Theoretical Population Biology 118 (2017) 50–73.","apa":"Barton, N. H., Etheridge, A., &#38; Véber, A. (2017). The infinitesimal model: Definition derivation and implications. <i>Theoretical Population Biology</i>. Academic Press. <a href=\"https://doi.org/10.1016/j.tpb.2017.06.001\">https://doi.org/10.1016/j.tpb.2017.06.001</a>"},"day":"01","file":[{"content_type":"application/pdf","access_level":"open_access","creator":"system","relation":"main_file","file_id":"4964","file_size":1133924,"date_created":"2018-12-12T10:12:45Z","checksum":"7dd02bfcfe8f244f4a6c19091aedf2c8","date_updated":"2020-07-14T12:47:25Z","file_name":"IST-2017-908-v1+1_1-s2.0-S0040580917300886-main_1_.pdf"}],"date_updated":"2021-01-12T08:06:50Z","abstract":[{"text":"Our focus here is on the infinitesimal model. In this model, one or several quantitative traits are described as the sum of a genetic and a non-genetic component, the first being distributed within families as a normal random variable centred at the average of the parental genetic components, and with a variance independent of the parental traits. Thus, the variance that segregates within families is not perturbed by selection, and can be predicted from the variance components. This does not necessarily imply that the trait distribution across the whole population should be Gaussian, and indeed selection or population structure may have a substantial effect on the overall trait distribution. One of our main aims is to identify some general conditions on the allelic effects for the infinitesimal model to be accurate. We first review the long history of the infinitesimal model in quantitative genetics. Then we formulate the model at the phenotypic level in terms of individual trait values and relationships between individuals, but including different evolutionary processes: genetic drift, recombination, selection, mutation, population structure, …. We give a range of examples of its application to evolutionary questions related to stabilising selection, assortative mating, effective population size and response to selection, habitat preference and speciation. We provide a mathematical justification of the model as the limit as the number M of underlying loci tends to infinity of a model with Mendelian inheritance, mutation and environmental noise, when the genetic component of the trait is purely additive. We also show how the model generalises to include epistatic effects. We prove in particular that, within each family, the genetic components of the individual trait values in the current generation are indeed normally distributed with a variance independent of ancestral traits, up to an error of order 1∕M. Simulations suggest that in some cases the convergence may be as fast as 1∕M.","lang":"eng"}],"ec_funded":1,"file_date_updated":"2020-07-14T12:47:25Z","publication_identifier":{"issn":["00405809"]},"language":[{"iso":"eng"}],"_id":"626","publication_status":"published","ddc":["576"],"project":[{"_id":"25B07788-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","grant_number":"250152","name":"Limits to selection in biology and in evolutionary computation"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"NiBa"}],"tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"doi":"10.1016/j.tpb.2017.06.001","publist_id":"7169","oa_version":"Published Version","year":"2017","type":"journal_article","scopus_import":1,"pubrep_id":"908"},{"ddc":["571"],"publication_status":"published","_id":"627","language":[{"iso":"eng"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"RySh"}],"abstract":[{"text":"Beige adipocytes are a new type of recruitable brownish adipocytes, with highly mitochondrial membrane uncoupling protein 1 expression and thermogenesis. Beige adipocytes were found among white adipocytes, especially in subcutaneous white adipose tissue (sWAT). Therefore, beige adipocytes may be involved in the regulation of energy metabolism and fat deposition. Transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable non-selective cation channel, plays vital roles in the regulation of various cellular functions. It has been reported that TRPM8 activation enhanced the thermogenic function of brown adiposytes. However, the involvement of TRPM8 in the thermogenic function of WAT remains unexplored. Our data revealed that TRPM8 was expressed in mouse white adipocytes at mRNA, protein and functional levels. The mRNA expression of Trpm8 was significantly increased in the differentiated white adipocytes than pre-adipocytes. Moreover, activation of TRPM8 by menthol enhanced the expression of thermogenic genes in cultured white aidpocytes. And menthol-induced increases of the thermogenic genes in white adipocytes was inhibited by either KT5720 (a protein kinase A inhibitor) or BAPTA-AM. In addition, high fat diet (HFD)-induced obesity in mice was significantly recovered by co-treatment with menthol. Dietary menthol enhanced WAT &quot;browning&quot; and improved glucose metabolism in HFD-induced obesity mice as well. Therefore, we concluded that TRPM8 might be involved in WAT &quot;browning&quot; by increasing the expression levels of genes related to thermogenesis and energy metabolism. And dietary menthol could be a novel approach for combating human obesity and related metabolic diseases.","lang":"eng"}],"article_processing_charge":"No","publication_identifier":{"issn":["1949-2553"]},"file_date_updated":"2020-07-14T12:47:26Z","scopus_import":"1","year":"2017","type":"journal_article","pubrep_id":"907","doi":"10.18632/oncotarget.20540","publist_id":"7167","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"oa_version":"Published Version","issue":"43","intvolume":"         8","publication":"Oncotarget","publisher":"Impact Journals","page":"75114 - 75126","quality_controlled":"1","status":"public","title":"Dietary menthol-induced TRPM8 activation enhances WAT “browning” and ameliorates diet-induced obesity","author":[{"last_name":"Jiang","first_name":"Changyu","full_name":"Jiang, Changyu"},{"last_name":"Zhai","first_name":"Ming-Zhu","full_name":"Zhai, Ming-Zhu","id":"34009CFA-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Yan, Dong","first_name":"Dong","last_name":"Yan"},{"full_name":"Li, Da","last_name":"Li","first_name":"Da"},{"full_name":"Li, Chen","last_name":"Li","first_name":"Chen"},{"last_name":"Zhang","first_name":"Yonghong","full_name":"Zhang, Yonghong"},{"last_name":"Xiao","first_name":"Lizu","full_name":"Xiao, Lizu"},{"first_name":"Donglin","last_name":"Xiong","full_name":"Xiong, Donglin"},{"first_name":"Qiwen","last_name":"Deng","full_name":"Deng, Qiwen"},{"full_name":"Sun, Wuping","first_name":"Wuping","last_name":"Sun"}],"oa":1,"date_updated":"2023-10-17T08:56:37Z","file":[{"file_size":6101606,"relation":"main_file","creator":"system","file_id":"5201","date_created":"2018-12-12T10:16:15Z","content_type":"application/pdf","access_level":"open_access","date_updated":"2020-07-14T12:47:26Z","file_name":"IST-2017-907-v1+1_20540-294640-4-PB.pdf","checksum":"2219e5348bbfe1aac2725aa620c33280"}],"day":"24","citation":{"ieee":"C. Jiang <i>et al.</i>, “Dietary menthol-induced TRPM8 activation enhances WAT ‘browning’ and ameliorates diet-induced obesity,” <i>Oncotarget</i>, vol. 8, no. 43. Impact Journals, pp. 75114–75126, 2017.","apa":"Jiang, C., Zhai, M.-Z., Yan, D., Li, D., Li, C., Zhang, Y., … Sun, W. (2017). Dietary menthol-induced TRPM8 activation enhances WAT “browning” and ameliorates diet-induced obesity. <i>Oncotarget</i>. Impact Journals. <a href=\"https://doi.org/10.18632/oncotarget.20540\">https://doi.org/10.18632/oncotarget.20540</a>","short":"C. Jiang, M.-Z. Zhai, D. Yan, D. Li, C. Li, Y. Zhang, L. Xiao, D. Xiong, Q. Deng, W. Sun, Oncotarget 8 (2017) 75114–75126.","mla":"Jiang, Changyu, et al. “Dietary Menthol-Induced TRPM8 Activation Enhances WAT ‘Browning’ and Ameliorates Diet-Induced Obesity.” <i>Oncotarget</i>, vol. 8, no. 43, Impact Journals, 2017, pp. 75114–26, doi:<a href=\"https://doi.org/10.18632/oncotarget.20540\">10.18632/oncotarget.20540</a>.","ista":"Jiang C, Zhai M-Z, Yan D, Li D, Li C, Zhang Y, Xiao L, Xiong D, Deng Q, Sun W. 2017. Dietary menthol-induced TRPM8 activation enhances WAT “browning” and ameliorates diet-induced obesity. Oncotarget. 8(43), 75114–75126.","ama":"Jiang C, Zhai M-Z, Yan D, et al. Dietary menthol-induced TRPM8 activation enhances WAT “browning” and ameliorates diet-induced obesity. <i>Oncotarget</i>. 2017;8(43):75114-75126. doi:<a href=\"https://doi.org/10.18632/oncotarget.20540\">10.18632/oncotarget.20540</a>","chicago":"Jiang, Changyu, Ming-Zhu Zhai, Dong Yan, Da Li, Chen Li, Yonghong Zhang, Lizu Xiao, Donglin Xiong, Qiwen Deng, and Wuping Sun. “Dietary Menthol-Induced TRPM8 Activation Enhances WAT ‘Browning’ and Ameliorates Diet-Induced Obesity.” <i>Oncotarget</i>. Impact Journals, 2017. <a href=\"https://doi.org/10.18632/oncotarget.20540\">https://doi.org/10.18632/oncotarget.20540</a>."},"volume":8,"has_accepted_license":"1","month":"08","date_published":"2017-08-24T00:00:00Z","date_created":"2018-12-11T11:47:34Z"},{"type":"conference","year":"2017","scopus_import":1,"doi":"10.1007/978-3-319-63387-9_6","publist_id":"7166","oa_version":"Submitted Version","language":[{"iso":"eng"}],"_id":"628","publication_status":"published","project":[{"name":"Efficient Algorithms for Computer Aided Verification","grant_number":"ICT15-003","_id":"25892FC0-B435-11E9-9278-68D0E5697425"},{"_id":"25863FF4-B435-11E9-9278-68D0E5697425","grant_number":"S11407","call_identifier":"FWF","name":"Game Theory"},{"name":"Quantitative Graph Games: Theory and Applications","grant_number":"279307","call_identifier":"FP7","_id":"2581B60A-B435-11E9-9278-68D0E5697425"}],"user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"KrCh"}],"abstract":[{"text":"We consider the problem of developing automated techniques for solving recurrence relations to aid the expected-runtime analysis of programs. The motivation is that several classical textbook algorithms have quite efficient expected-runtime complexity, whereas the corresponding worst-case bounds are either inefficient (e.g., Quick-Sort), or completely ineffective (e.g., Coupon-Collector). Since the main focus of expected-runtime analysis is to obtain efficient bounds, we consider bounds that are either logarithmic, linear or almost-linear (O(log n), O(n), O(n · log n), respectively, where n represents the input size). Our main contribution is an efficient (simple linear-time algorithm) sound approach for deriving such expected-runtime bounds for the analysis of recurrence relations induced by randomized algorithms. The experimental results show that our approach can efficiently derive asymptotically optimal expected-runtime bounds for recurrences of classical randomized algorithms, including Randomized-Search, Quick-Sort, Quick-Select, Coupon-Collector, where the worst-case bounds are either inefficient (such as linear as compared to logarithmic expected-runtime complexity, or quadratic as compared to linear or almost-linear expected-runtime complexity), or ineffective.","lang":"eng"}],"ec_funded":1,"publication_identifier":{"isbn":["978-331963386-2"]},"alternative_title":["LNCS"],"conference":{"end_date":"2017-07-28","start_date":"2017-07-24","location":"Heidelberg, Germany","name":"CAV: Computer Aided Verification"},"citation":{"mla":"Chatterjee, Krishnendu, et al. <i>Automated Recurrence Analysis for Almost Linear Expected Runtime Bounds</i>. Edited by Rupak Majumdar and Viktor Kunčak, vol. 10426, Springer, 2017, pp. 118–39, doi:<a href=\"https://doi.org/10.1007/978-3-319-63387-9_6\">10.1007/978-3-319-63387-9_6</a>.","ista":"Chatterjee K, Fu H, Murhekar A. 2017. Automated recurrence analysis for almost linear expected runtime bounds. CAV: Computer Aided Verification, LNCS, vol. 10426, 118–139.","ama":"Chatterjee K, Fu H, Murhekar A. Automated recurrence analysis for almost linear expected runtime bounds. In: Majumdar R, Kunčak V, eds. Vol 10426. Springer; 2017:118-139. doi:<a href=\"https://doi.org/10.1007/978-3-319-63387-9_6\">10.1007/978-3-319-63387-9_6</a>","chicago":"Chatterjee, Krishnendu, Hongfei Fu, and Aniket Murhekar. “Automated Recurrence Analysis for Almost Linear Expected Runtime Bounds.” edited by Rupak Majumdar and Viktor Kunčak, 10426:118–39. Springer, 2017. <a href=\"https://doi.org/10.1007/978-3-319-63387-9_6\">https://doi.org/10.1007/978-3-319-63387-9_6</a>.","ieee":"K. Chatterjee, H. Fu, and A. Murhekar, “Automated recurrence analysis for almost linear expected runtime bounds,” presented at the CAV: Computer Aided Verification, Heidelberg, Germany, 2017, vol. 10426, pp. 118–139.","apa":"Chatterjee, K., Fu, H., &#38; Murhekar, A. (2017). Automated recurrence analysis for almost linear expected runtime bounds. In R. Majumdar &#38; V. Kunčak (Eds.) (Vol. 10426, pp. 118–139). Presented at the CAV: Computer Aided Verification, Heidelberg, Germany: Springer. <a href=\"https://doi.org/10.1007/978-3-319-63387-9_6\">https://doi.org/10.1007/978-3-319-63387-9_6</a>","short":"K. Chatterjee, H. Fu, A. Murhekar, in:, R. Majumdar, V. Kunčak (Eds.), Springer, 2017, pp. 118–139."},"day":"01","date_updated":"2021-01-12T08:06:55Z","editor":[{"first_name":"Rupak","last_name":"Majumdar","full_name":"Majumdar, Rupak"},{"full_name":"Kunčak, Viktor","first_name":"Viktor","last_name":"Kunčak"}],"volume":10426,"date_created":"2018-12-11T11:47:35Z","date_published":"2017-01-01T00:00:00Z","month":"01","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1705.00314"}],"page":"118 - 139","quality_controlled":"1","publisher":"Springer","intvolume":"     10426","title":"Automated recurrence analysis for almost linear expected runtime bounds","status":"public","oa":1,"author":[{"full_name":"Chatterjee, Krishnendu","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","last_name":"Chatterjee","orcid":"0000-0002-4561-241X","first_name":"Krishnendu"},{"last_name":"Fu","first_name":"Hongfei","full_name":"Fu, Hongfei"},{"first_name":"Aniket","last_name":"Murhekar","full_name":"Murhekar, Aniket"}]},{"publication_identifier":{"issn":["2663-337X"]},"file_date_updated":"2020-07-14T12:47:26Z","alternative_title":["ISTA Thesis"],"article_processing_charge":"No","abstract":[{"text":"The main objects considered in the present work are simplicial and CW-complexes with vertices forming a random point cloud. In particular, we consider a Poisson point process in R^n and study Delaunay and Voronoi complexes of the first and higher orders and weighted Delaunay complexes obtained as sections of Delaunay complexes, as well as the Čech complex. Further, we examine theDelaunay complex of a Poisson point process on the sphere S^n, as well as of a uniform point cloud, which is equivalent to the convex hull, providing a connection to the theory of random polytopes. Each of the complexes in question can be endowed with a radius function, which maps its cells to the radii of appropriately chosen circumspheres, called the radius of the cell. Applying and developing discrete Morse theory for these functions, joining it together with probabilistic and sometimes analytic machinery, and developing several integral geometric tools, we aim at getting the distributions of circumradii of typical cells. For all considered complexes, we are able to generalize and obtain up to constants the distribution of radii of typical intervals of all types. In low dimensions the constants can be computed explicitly, thus providing the explicit expressions for the expected numbers of cells. In particular, it allows to find the expected density of simplices of every dimension for a Poisson point process in R^4, whereas the result for R^3 was known already in 1970's.","lang":"eng"}],"department":[{"_id":"HeEd"}],"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","ddc":["514","516","519"],"publication_status":"published","language":[{"iso":"eng"}],"_id":"6287","oa_version":"Published Version","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"supervisor":[{"full_name":"Edelsbrunner, Herbert","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","first_name":"Herbert","last_name":"Edelsbrunner","orcid":"0000-0002-9823-6833"}],"doi":"10.15479/AT:ISTA:th_873","pubrep_id":"873","type":"dissertation","year":"2017","oa":1,"author":[{"last_name":"Nikitenko","orcid":"0000-0002-0659-3201","first_name":"Anton","full_name":"Nikitenko, Anton","id":"3E4FF1BA-F248-11E8-B48F-1D18A9856A87"}],"title":"Discrete Morse theory for random complexes ","status":"public","publisher":"Institute of Science and Technology Austria","page":"86","date_created":"2019-04-09T15:04:32Z","date_published":"2017-10-27T00:00:00Z","month":"10","has_accepted_license":"1","degree_awarded":"PhD","file":[{"access_level":"open_access","content_type":"application/pdf","date_created":"2019-04-09T14:54:51Z","file_size":2324870,"file_id":"6289","relation":"main_file","creator":"dernst","checksum":"ece7e598a2f060b263c2febf7f3fe7f9","file_name":"2017_Thesis_Nikitenko.pdf","date_updated":"2020-07-14T12:47:26Z"},{"access_level":"closed","content_type":"application/zip","date_created":"2019-04-09T14:54:51Z","file_size":2863219,"relation":"source_file","file_id":"6290","creator":"dernst","checksum":"99b7ad76e317efd447af60f91e29b49b","file_name":"2017_Thesis_Nikitenko_source.zip","date_updated":"2020-07-14T12:47:26Z"}],"day":"27","citation":{"ama":"Nikitenko A. Discrete Morse theory for random complexes . 2017. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:th_873\">10.15479/AT:ISTA:th_873</a>","ista":"Nikitenko A. 2017. Discrete Morse theory for random complexes . Institute of Science and Technology Austria.","mla":"Nikitenko, Anton. <i>Discrete Morse Theory for Random Complexes </i>. Institute of Science and Technology Austria, 2017, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:th_873\">10.15479/AT:ISTA:th_873</a>.","chicago":"Nikitenko, Anton. “Discrete Morse Theory for Random Complexes .” Institute of Science and Technology Austria, 2017. <a href=\"https://doi.org/10.15479/AT:ISTA:th_873\">https://doi.org/10.15479/AT:ISTA:th_873</a>.","apa":"Nikitenko, A. (2017). <i>Discrete Morse theory for random complexes </i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:th_873\">https://doi.org/10.15479/AT:ISTA:th_873</a>","short":"A. Nikitenko, Discrete Morse Theory for Random Complexes , Institute of Science and Technology Austria, 2017.","ieee":"A. Nikitenko, “Discrete Morse theory for random complexes ,” Institute of Science and Technology Austria, 2017."},"date_updated":"2023-09-15T12:10:34Z","related_material":{"record":[{"id":"718","relation":"part_of_dissertation","status":"public"},{"status":"public","relation":"part_of_dissertation","id":"5678"},{"status":"public","id":"87","relation":"part_of_dissertation"}]}},{"oa_version":"None","pmid":1,"publist_id":"7165","doi":"10.1007/978-3-319-53047-5_15","scopus_import":1,"year":"2017","type":"book_chapter","publication_identifier":{"eisbn":["978-3-319-53047-5"]},"abstract":[{"text":"Even simple cells like bacteria have precisely regulated cellular anatomies, which allow them to grow, divide and to respond to internal or external cues with high fidelity. How spatial and temporal intracellular organization in prokaryotic cells is achieved and maintained on the basis of locally interacting proteins still remains largely a mystery. Bulk biochemical assays with purified components and in vivo experiments help us to approach key cellular processes from two opposite ends, in terms of minimal and maximal complexity. However, to understand how cellular phenomena emerge, that are more than the sum of their parts, we have to assemble cellular subsystems step by step from the bottom up. Here, we review recent in vitro reconstitution experiments with proteins of the bacterial cell division machinery and illustrate how they help to shed light on fundamental cellular mechanisms that constitute spatiotemporal order and regulate cell division.","lang":"eng"}],"external_id":{"pmid":["28500535"]},"department":[{"_id":"MaLo"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","series_title":"Sub-Cellular Biochemistry","publication_status":"published","language":[{"iso":"eng"}],"_id":"629","date_created":"2018-12-11T11:47:35Z","date_published":"2017-05-13T00:00:00Z","month":"05","volume":84,"citation":{"chicago":"Loose, Martin, Katja Zieske, and Petra Schwille. “Reconstitution of Protein Dynamics Involved in Bacterial Cell Division.” In <i>Prokaryotic Cytoskeletons</i>, 84:419–44. Sub-Cellular Biochemistry. Springer, 2017. <a href=\"https://doi.org/10.1007/978-3-319-53047-5_15\">https://doi.org/10.1007/978-3-319-53047-5_15</a>.","mla":"Loose, Martin, et al. “Reconstitution of Protein Dynamics Involved in Bacterial Cell Division.” <i>Prokaryotic Cytoskeletons</i>, vol. 84, Springer, 2017, pp. 419–44, doi:<a href=\"https://doi.org/10.1007/978-3-319-53047-5_15\">10.1007/978-3-319-53047-5_15</a>.","ama":"Loose M, Zieske K, Schwille P. Reconstitution of protein dynamics involved in bacterial cell division. In: <i>Prokaryotic Cytoskeletons</i>. Vol 84. Sub-Cellular Biochemistry. Springer; 2017:419-444. doi:<a href=\"https://doi.org/10.1007/978-3-319-53047-5_15\">10.1007/978-3-319-53047-5_15</a>","ista":"Loose M, Zieske K, Schwille P. 2017.Reconstitution of protein dynamics involved in bacterial cell division. In: Prokaryotic Cytoskeletons. vol. 84, 419–444.","ieee":"M. Loose, K. Zieske, and P. Schwille, “Reconstitution of protein dynamics involved in bacterial cell division,” in <i>Prokaryotic Cytoskeletons</i>, vol. 84, Springer, 2017, pp. 419–444.","apa":"Loose, M., Zieske, K., &#38; Schwille, P. (2017). Reconstitution of protein dynamics involved in bacterial cell division. In <i>Prokaryotic Cytoskeletons</i> (Vol. 84, pp. 419–444). Springer. <a href=\"https://doi.org/10.1007/978-3-319-53047-5_15\">https://doi.org/10.1007/978-3-319-53047-5_15</a>","short":"M. Loose, K. Zieske, P. Schwille, in:, Prokaryotic Cytoskeletons, Springer, 2017, pp. 419–444."},"day":"13","date_updated":"2021-01-12T08:06:57Z","author":[{"full_name":"Loose, Martin","id":"462D4284-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-7309-9724","last_name":"Loose","first_name":"Martin"},{"full_name":"Zieske, Katja","last_name":"Zieske","first_name":"Katja"},{"last_name":"Schwille","first_name":"Petra","full_name":"Schwille, Petra"}],"title":"Reconstitution of protein dynamics involved in bacterial cell division","status":"public","publisher":"Springer","page":"419 - 444","quality_controlled":"1","intvolume":"        84","publication":"Prokaryotic Cytoskeletons"},{"month":"02","date_published":"2017-02-01T00:00:00Z","date_created":"2019-04-09T15:16:45Z","oa_version":"Published Version","degree_awarded":"PhD","supervisor":[{"id":"2C6FA9CC-F248-11E8-B48F-1D18A9856A87","full_name":"Bollback, Jonathan P","orcid":"0000-0002-4624-4612","last_name":"Bollback","first_name":"Jonathan P"},{"full_name":"Barton, Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","last_name":"Barton","orcid":"0000-0002-8548-5240","first_name":"Nicholas H"}],"has_accepted_license":"1","date_updated":"2023-09-07T12:00:00Z","day":"01","citation":{"chicago":"Payne, Pavel. “Bacterial Herd and Social Immunity to Phages.” Institute of Science and Technology Austria, 2017.","ama":"Payne P. Bacterial herd and social immunity to phages. 2017.","ista":"Payne P. 2017. Bacterial herd and social immunity to phages. Institute of Science and Technology Austria.","mla":"Payne, Pavel. <i>Bacterial Herd and Social Immunity to Phages</i>. Institute of Science and Technology Austria, 2017.","short":"P. Payne, Bacterial Herd and Social Immunity to Phages, Institute of Science and Technology Austria, 2017.","apa":"Payne, P. (2017). <i>Bacterial herd and social immunity to phages</i>. Institute of Science and Technology Austria.","ieee":"P. Payne, “Bacterial herd and social immunity to phages,” Institute of Science and Technology Austria, 2017."},"file":[{"file_id":"6292","creator":"dernst","relation":"main_file","file_size":3025175,"date_created":"2019-04-09T15:15:32Z","content_type":"application/pdf","access_level":"closed","date_updated":"2020-07-14T12:47:27Z","file_name":"thesis_pavel_payne_final_w_signature_page.pdf","checksum":"a0fc5c26a89c0ea759947ffba87d0d8f"},{"access_level":"open_access","content_type":"application/pdf","date_created":"2021-02-22T13:45:59Z","creator":"dernst","relation":"main_file","file_id":"9187","file_size":3111536,"checksum":"af531e921a7f64a9e0af4cd8783b2226","file_name":"2017_Payne_Thesis.pdf","success":1,"date_updated":"2021-02-22T13:45:59Z"}],"type":"dissertation","year":"2017","article_processing_charge":"No","author":[{"first_name":"Pavel","last_name":"Payne","orcid":"0000-0002-2711-9453","id":"35F78294-F248-11E8-B48F-1D18A9856A87","full_name":"Payne, Pavel"}],"alternative_title":["ISTA Thesis"],"file_date_updated":"2021-02-22T13:45:59Z","oa":1,"publication_identifier":{"issn":["2663-337X"]},"status":"public","abstract":[{"lang":"eng","text":"Bacteria and their pathogens – phages – are the most abundant living entities on Earth. Throughout their coevolution, bacteria have evolved multiple immune systems to overcome the ubiquitous threat from the phages. Although the molecu- lar details of these immune systems’ functions are relatively well understood, their epidemiological consequences for the phage-bacterial communities have been largely neglected. In this thesis we employed both experimental and theoretical methods to explore whether herd and social immunity may arise in bacterial popu- lations. Using our experimental system consisting of Escherichia coli strains with a CRISPR based immunity to the T7 phage we show that herd immunity arises in phage-bacterial communities and that it is accentuated when the populations are spatially structured. By fitting a mathematical model, we inferred expressions for the herd immunity threshold and the velocity of spread of a phage epidemic in partially resistant bacterial populations, which both depend on the bacterial growth rate, phage burst size and phage latent period. We also investigated the poten- tial for social immunity in Streptococcus thermophilus and its phage 2972 using a bioinformatic analysis of potentially coding short open reading frames with a signalling signature, encoded within the CRISPR associated genes. Subsequently, we tested one identified potentially signalling peptide and found that its addition to a phage-challenged culture increases probability of survival of bacteria two fold, although the results were only marginally significant. Together, these results demonstrate that the ubiquitous arms races between bacteria and phages have further consequences at the level of the population."}],"title":"Bacterial herd and social immunity to phages","department":[{"_id":"NiBa"},{"_id":"JoBo"}],"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","page":"83","publisher":"Institute of Science and Technology Austria","language":[{"iso":"eng"}],"_id":"6291","ddc":["570"],"publication_status":"published"},{"publication_status":"published","ddc":["005"],"_id":"630","language":[{"iso":"eng"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"ScienComp"},{"_id":"PeJo"}],"abstract":[{"text":"Background: Standards have become available to share semantically encoded vital parameters from medical devices, as required for example by personal healthcare records. Standardised sharing of biosignal data largely remains open. Objectives: The goal of this work is to explore available biosignal file format and data exchange standards and profiles, and to conceptualise end-To-end solutions. Methods: The authors reviewed and discussed available biosignal file format standards with other members of international standards development organisations (SDOs). Results: A raw concept for standards based acquisition, storage, archiving and sharing of biosignals was developed. The GDF format may serve for storing biosignals. Signals can then be shared using FHIR resources and may be stored on FHIR servers or in DICOM archives, with DICOM waveforms as one possible format. Conclusion: Currently a group of international SDOs (e.g. HL7, IHE, DICOM, IEEE) is engaged in intensive discussions. This discussion extends existing work that already was adopted by large implementer communities. The concept presented here only reports the current status of the discussion in Austria. The discussion will continue internationally, with results to be expected over the coming years.","lang":"eng"}],"publication_identifier":{"isbn":["978-161499758-0"]},"file_date_updated":"2020-07-14T12:47:27Z","alternative_title":["Studies in Health Technology and Informatics"],"scopus_import":1,"type":"conference","year":"2017","pubrep_id":"906","tmp":{"name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","short":"CC BY-NC (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","image":"/images/cc_by_nc.png"},"publist_id":"7164","doi":"10.3233/978-1-61499-759-7-356","oa_version":"Published Version","publisher":"IOS Press","page":"356 - 362","quality_controlled":"1","intvolume":"       236","title":"Biosignals standards and FHIR: The way to go","status":"public","oa":1,"author":[{"full_name":"Sauermann, Stefan","last_name":"Sauermann","first_name":"Stefan"},{"full_name":"David, Veronika","first_name":"Veronika","last_name":"David"},{"last_name":"Schlögl","orcid":"0000-0002-5621-8100","first_name":"Alois","id":"45BF87EE-F248-11E8-B48F-1D18A9856A87","full_name":"Schlögl, Alois"},{"last_name":"Egelkraut","first_name":"Reinhard","full_name":"Egelkraut, Reinhard"},{"last_name":"Frohner","first_name":"Matthias","full_name":"Frohner, Matthias"},{"full_name":"Pohn, Birgit","first_name":"Birgit","last_name":"Pohn"},{"full_name":"Urbauer, Philipp","last_name":"Urbauer","first_name":"Philipp"},{"first_name":"Alexander","last_name":"Mense","full_name":"Mense, Alexander"}],"conference":{"start_date":"2017-05-23","location":"Vienna, Austria","end_date":"2017-05-24","name":"eHealth: Health Informatics Meets eHealth"},"file":[{"checksum":"1254dcc5b04a996d97fad9a726b42727","date_updated":"2020-07-14T12:47:27Z","file_name":"IST-2017-906-v1+1_SHTI236-0356.pdf","content_type":"application/pdf","access_level":"open_access","file_size":443635,"creator":"system","relation":"main_file","file_id":"4913","date_created":"2018-12-12T10:11:56Z"}],"citation":{"chicago":"Sauermann, Stefan, Veronika David, Alois Schlögl, Reinhard Egelkraut, Matthias Frohner, Birgit Pohn, Philipp Urbauer, and Alexander Mense. “Biosignals Standards and FHIR: The Way to Go,” 236:356–62. IOS Press, 2017. <a href=\"https://doi.org/10.3233/978-1-61499-759-7-356\">https://doi.org/10.3233/978-1-61499-759-7-356</a>.","ista":"Sauermann S, David V, Schlögl A, Egelkraut R, Frohner M, Pohn B, Urbauer P, Mense A. 2017. Biosignals standards and FHIR: The way to go. eHealth: Health Informatics Meets eHealth, Studies in Health Technology and Informatics, vol. 236, 356–362.","ama":"Sauermann S, David V, Schlögl A, et al. Biosignals standards and FHIR: The way to go. In: Vol 236. IOS Press; 2017:356-362. doi:<a href=\"https://doi.org/10.3233/978-1-61499-759-7-356\">10.3233/978-1-61499-759-7-356</a>","mla":"Sauermann, Stefan, et al. <i>Biosignals Standards and FHIR: The Way to Go</i>. Vol. 236, IOS Press, 2017, pp. 356–62, doi:<a href=\"https://doi.org/10.3233/978-1-61499-759-7-356\">10.3233/978-1-61499-759-7-356</a>.","short":"S. Sauermann, V. David, A. Schlögl, R. Egelkraut, M. Frohner, B. Pohn, P. Urbauer, A. Mense, in:, IOS Press, 2017, pp. 356–362.","apa":"Sauermann, S., David, V., Schlögl, A., Egelkraut, R., Frohner, M., Pohn, B., … Mense, A. (2017). Biosignals standards and FHIR: The way to go (Vol. 236, pp. 356–362). Presented at the eHealth: Health Informatics Meets eHealth, Vienna, Austria: IOS Press. <a href=\"https://doi.org/10.3233/978-1-61499-759-7-356\">https://doi.org/10.3233/978-1-61499-759-7-356</a>","ieee":"S. Sauermann <i>et al.</i>, “Biosignals standards and FHIR: The way to go,” presented at the eHealth: Health Informatics Meets eHealth, Vienna, Austria, 2017, vol. 236, pp. 356–362."},"day":"01","date_updated":"2021-01-12T08:06:59Z","has_accepted_license":"1","volume":236,"date_published":"2017-01-01T00:00:00Z","date_created":"2018-12-11T11:47:36Z","month":"01"},{"pubrep_id":"966","type":"conference","year":"2017","scopus_import":1,"oa_version":"Submitted Version","publist_id":"7162","doi":"10.1007/978-3-662-54577-5_34","project":[{"name":"Moderne Concurrency Paradigms","_id":"25F5A88A-B435-11E9-9278-68D0E5697425","grant_number":"S11402-N23","call_identifier":"FWF"},{"name":"The Wittgenstein Prize","grant_number":"Z211","call_identifier":"FWF","_id":"25F42A32-B435-11E9-9278-68D0E5697425"}],"department":[{"_id":"ToHe"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","language":[{"iso":"eng"}],"_id":"631","ddc":["000"],"publication_status":"published","file_date_updated":"2020-07-14T12:47:27Z","publication_identifier":{"isbn":["978-366254576-8"]},"alternative_title":["LNCS"],"acknowledgement":"This research was supported in part by the Austrian Science Fund (FWF) under grants S11402-N23 (RiSE/SHiNE) and Z211-N23 (Wittgenstein Award), by the European Commission under grant 643921 (UnCoVerCPS), and by the ARC project DP140104219 (Robust AI Planning for Hybrid Systems).","abstract":[{"text":"Template polyhedra generalize intervals and octagons to polyhedra whose facets are orthogonal to a given set of arbitrary directions. They have been employed in the abstract interpretation of programs and, with particular success, in the reachability analysis of hybrid automata. While previously, the choice of directions has been left to the user or a heuristic, we present a method for the automatic discovery of directions that generalize and eliminate spurious counterexamples. We show that for the class of convex hybrid automata, i.e., hybrid automata with (possibly nonlinear) convex constraints on derivatives, such directions always exist and can be found using convex optimization. We embed our method inside a CEGAR loop, thus enabling the time-unbounded reachability analysis of an important and richer class of hybrid automata than was previously possible. We evaluate our method on several benchmarks, demonstrating also its superior efficiency for the special case of linear hybrid automata.","lang":"eng"}],"citation":{"mla":"Bogomolov, Sergiy, et al. <i>Counterexample Guided Refinement of Template Polyhedra</i>. Vol. 10205, Springer, 2017, pp. 589–606, doi:<a href=\"https://doi.org/10.1007/978-3-662-54577-5_34\">10.1007/978-3-662-54577-5_34</a>.","ama":"Bogomolov S, Frehse G, Giacobbe M, Henzinger TA. Counterexample guided refinement of template polyhedra. In: Vol 10205. Springer; 2017:589-606. doi:<a href=\"https://doi.org/10.1007/978-3-662-54577-5_34\">10.1007/978-3-662-54577-5_34</a>","ista":"Bogomolov S, Frehse G, Giacobbe M, Henzinger TA. 2017. Counterexample guided refinement of template polyhedra. TACAS: Tools and Algorithms for the Construction and Analysis of Systems, LNCS, vol. 10205, 589–606.","chicago":"Bogomolov, Sergiy, Goran Frehse, Mirco Giacobbe, and Thomas A Henzinger. “Counterexample Guided Refinement of Template Polyhedra,” 10205:589–606. Springer, 2017. <a href=\"https://doi.org/10.1007/978-3-662-54577-5_34\">https://doi.org/10.1007/978-3-662-54577-5_34</a>.","ieee":"S. Bogomolov, G. Frehse, M. Giacobbe, and T. A. Henzinger, “Counterexample guided refinement of template polyhedra,” presented at the TACAS: Tools and Algorithms for the Construction and Analysis of Systems, Uppsala, Sweden, 2017, vol. 10205, pp. 589–606.","apa":"Bogomolov, S., Frehse, G., Giacobbe, M., &#38; Henzinger, T. A. (2017). Counterexample guided refinement of template polyhedra (Vol. 10205, pp. 589–606). Presented at the TACAS: Tools and Algorithms for the Construction and Analysis of Systems, Uppsala, Sweden: Springer. <a href=\"https://doi.org/10.1007/978-3-662-54577-5_34\">https://doi.org/10.1007/978-3-662-54577-5_34</a>","short":"S. Bogomolov, G. Frehse, M. Giacobbe, T.A. Henzinger, in:, Springer, 2017, pp. 589–606."},"day":"31","file":[{"content_type":"application/pdf","access_level":"open_access","file_size":569863,"creator":"system","relation":"main_file","file_id":"4897","date_created":"2018-12-12T10:11:41Z","checksum":"f395d0d20102b89aeaad8b4ef4f18f4f","date_updated":"2020-07-14T12:47:27Z","file_name":"IST-2017-741-v1+1_main.pdf"},{"file_id":"4898","creator":"system","relation":"main_file","file_size":563276,"date_created":"2018-12-12T10:11:42Z","content_type":"application/pdf","access_level":"open_access","date_updated":"2020-07-14T12:47:27Z","file_name":"IST-2018-741-v2+2_main.pdf","checksum":"f416ee1ae4497b23ecdf28b1f18bb8df"}],"date_updated":"2023-09-07T12:53:00Z","conference":{"name":"TACAS: Tools and Algorithms for the Construction and Analysis of Systems","end_date":"2017-04-29","start_date":"2017-04-22","location":"Uppsala, Sweden"},"related_material":{"record":[{"status":"public","relation":"dissertation_contains","id":"6894"}]},"date_published":"2017-03-31T00:00:00Z","date_created":"2018-12-11T11:47:36Z","month":"03","has_accepted_license":"1","volume":10205,"page":"589 - 606","quality_controlled":"1","publisher":"Springer","intvolume":"     10205","oa":1,"author":[{"last_name":"Bogomolov","orcid":"0000-0002-0686-0365","first_name":"Sergiy","full_name":"Bogomolov, Sergiy","id":"369D9A44-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Frehse, Goran","first_name":"Goran","last_name":"Frehse"},{"full_name":"Giacobbe, Mirco","id":"3444EA5E-F248-11E8-B48F-1D18A9856A87","first_name":"Mirco","orcid":"0000-0001-8180-0904","last_name":"Giacobbe"},{"first_name":"Thomas A","last_name":"Henzinger","orcid":"0000−0002−2985−7724","full_name":"Henzinger, Thomas A","id":"40876CD8-F248-11E8-B48F-1D18A9856A87"}],"title":"Counterexample guided refinement of template polyhedra","status":"public"},{"date_created":"2018-12-11T11:47:36Z","date_published":"2017-01-01T00:00:00Z","month":"01","volume":145,"citation":{"chicago":"Lewin, Mathieu, Phan Nam, and Nicolas Rougerie. “A Note on 2D Focusing Many Boson Systems.” <i>Proceedings of the American Mathematical Society</i>. American Mathematical Society, 2017. <a href=\"https://doi.org/10.1090/proc/13468\">https://doi.org/10.1090/proc/13468</a>.","mla":"Lewin, Mathieu, et al. “A Note on 2D Focusing Many Boson Systems.” <i>Proceedings of the American Mathematical Society</i>, vol. 145, no. 6, American Mathematical Society, 2017, pp. 2441–54, doi:<a href=\"https://doi.org/10.1090/proc/13468\">10.1090/proc/13468</a>.","ista":"Lewin M, Nam P, Rougerie N. 2017. A note on 2D focusing many boson systems. Proceedings of the American Mathematical Society. 145(6), 2441–2454.","ama":"Lewin M, Nam P, Rougerie N. A note on 2D focusing many boson systems. <i>Proceedings of the American Mathematical Society</i>. 2017;145(6):2441-2454. doi:<a href=\"https://doi.org/10.1090/proc/13468\">10.1090/proc/13468</a>","ieee":"M. Lewin, P. Nam, and N. Rougerie, “A note on 2D focusing many boson systems,” <i>Proceedings of the American Mathematical Society</i>, vol. 145, no. 6. American Mathematical Society, pp. 2441–2454, 2017.","short":"M. Lewin, P. Nam, N. Rougerie, Proceedings of the American Mathematical Society 145 (2017) 2441–2454.","apa":"Lewin, M., Nam, P., &#38; Rougerie, N. (2017). A note on 2D focusing many boson systems. <i>Proceedings of the American Mathematical Society</i>. American Mathematical Society. <a href=\"https://doi.org/10.1090/proc/13468\">https://doi.org/10.1090/proc/13468</a>"},"day":"01","date_updated":"2021-01-12T08:07:03Z","oa":1,"author":[{"last_name":"Lewin","first_name":"Mathieu","full_name":"Lewin, Mathieu"},{"id":"404092F4-F248-11E8-B48F-1D18A9856A87","full_name":"Nam, Phan","last_name":"Nam","first_name":"Phan"},{"full_name":"Rougerie, Nicolas","last_name":"Rougerie","first_name":"Nicolas"}],"title":"A note on 2D focusing many boson systems","status":"public","page":"2441 - 2454","quality_controlled":"1","main_file_link":[{"url":"https://arxiv.org/abs/1509.09045","open_access":"1"}],"publisher":"American Mathematical Society","publication":"Proceedings of the American Mathematical Society","intvolume":"       145","issue":"6","oa_version":"Submitted Version","publist_id":"7160","doi":"10.1090/proc/13468","year":"2017","type":"journal_article","scopus_import":1,"abstract":[{"lang":"eng","text":"We consider a 2D quantum system of N bosons in a trapping potential |x|s, interacting via a pair potential of the form N2β−1 w(Nβ x). We show that for all 0 &lt; β &lt; (s + 1)/(s + 2), the leading order behavior of ground states of the many-body system is described in the large N limit by the corresponding cubic nonlinear Schrödinger energy functional. Our result covers the focusing case (w &lt; 0) where even the stability of the many-body system is not obvious. This answers an open question mentioned by X. Chen and J. Holmer for harmonic traps (s = 2). Together with the BBGKY hierarchy approach used by these authors, our result implies the convergence of the many-body quantum dynamics to the focusing NLS equation with harmonic trap for all 0 &lt; β &lt; 3/4. "}],"ec_funded":1,"project":[{"call_identifier":"FP7","grant_number":"291734","_id":"25681D80-B435-11E9-9278-68D0E5697425","name":"International IST Postdoc Fellowship Programme"}],"department":[{"_id":"RoSe"}],"user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","language":[{"iso":"eng"}],"_id":"632","publication_status":"published"},{"publication_identifier":{"isbn":["978-331963500-2"]},"alternative_title":["LNCS"],"abstract":[{"lang":"eng","text":"A Rapidly-exploring Random Tree (RRT) is an algorithm which can search a non-convex region of space by incrementally building a space-filling tree. The tree is constructed from random points drawn from system’s state space and is biased to grow towards large unexplored areas in the system. RRT can provide better coverage of a system’s possible behaviors compared with random simulations, but is more lightweight than full reachability analysis. In this paper, we explore some of the design decisions encountered while implementing a hybrid extension of the RRT algorithm, which have not been elaborated on before. In particular, we focus on handling non-determinism, which arises due to discrete transitions. We introduce the notion of important points to account for this phenomena. We showcase our ideas using heater and navigation benchmarks."}],"project":[{"_id":"25F5A88A-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","grant_number":"S11402-N23","name":"Moderne Concurrency Paradigms"},{"_id":"25F42A32-B435-11E9-9278-68D0E5697425","grant_number":"Z211","call_identifier":"FWF","name":"The Wittgenstein Prize"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"ToHe"}],"_id":"633","language":[{"iso":"eng"}],"publication_status":"published","oa_version":"None","doi":"10.1007/978-3-319-63501-9_6","publist_id":"7159","year":"2017","type":"conference","scopus_import":1,"author":[{"first_name":"Stanley","last_name":"Bak","full_name":"Bak, Stanley"},{"last_name":"Bogomolov","orcid":"0000-0002-0686-0365","first_name":"Sergiy","id":"369D9A44-F248-11E8-B48F-1D18A9856A87","full_name":"Bogomolov, Sergiy"},{"orcid":"0000−0002−2985−7724","last_name":"Henzinger","first_name":"Thomas A","full_name":"Henzinger, Thomas A","id":"40876CD8-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Kumar, Aviral","last_name":"Kumar","first_name":"Aviral"}],"title":"Challenges and tool implementation of hybrid rapidly exploring random trees","status":"public","page":"83 - 89","quality_controlled":"1","publisher":"Springer","intvolume":"     10381","date_created":"2018-12-11T11:47:37Z","date_published":"2017-01-01T00:00:00Z","month":"01","volume":10381,"day":"01","citation":{"chicago":"Bak, Stanley, Sergiy Bogomolov, Thomas A Henzinger, and Aviral Kumar. “Challenges and Tool Implementation of Hybrid Rapidly Exploring Random Trees.” edited by Alessandro Abate and Sylvie Bodo, 10381:83–89. Springer, 2017. <a href=\"https://doi.org/10.1007/978-3-319-63501-9_6\">https://doi.org/10.1007/978-3-319-63501-9_6</a>.","ista":"Bak S, Bogomolov S, Henzinger TA, Kumar A. 2017. Challenges and tool implementation of hybrid rapidly exploring random trees. NSV: Numerical Software Verification, LNCS, vol. 10381, 83–89.","ama":"Bak S, Bogomolov S, Henzinger TA, Kumar A. Challenges and tool implementation of hybrid rapidly exploring random trees. In: Abate A, Bodo S, eds. Vol 10381. Springer; 2017:83-89. doi:<a href=\"https://doi.org/10.1007/978-3-319-63501-9_6\">10.1007/978-3-319-63501-9_6</a>","mla":"Bak, Stanley, et al. <i>Challenges and Tool Implementation of Hybrid Rapidly Exploring Random Trees</i>. Edited by Alessandro Abate and Sylvie Bodo, vol. 10381, Springer, 2017, pp. 83–89, doi:<a href=\"https://doi.org/10.1007/978-3-319-63501-9_6\">10.1007/978-3-319-63501-9_6</a>.","apa":"Bak, S., Bogomolov, S., Henzinger, T. A., &#38; Kumar, A. (2017). Challenges and tool implementation of hybrid rapidly exploring random trees. In A. Abate &#38; S. Bodo (Eds.) (Vol. 10381, pp. 83–89). Presented at the NSV: Numerical Software Verification, Heidelberg, Germany: Springer. <a href=\"https://doi.org/10.1007/978-3-319-63501-9_6\">https://doi.org/10.1007/978-3-319-63501-9_6</a>","short":"S. Bak, S. Bogomolov, T.A. Henzinger, A. Kumar, in:, A. Abate, S. Bodo (Eds.), Springer, 2017, pp. 83–89.","ieee":"S. Bak, S. Bogomolov, T. A. Henzinger, and A. Kumar, “Challenges and tool implementation of hybrid rapidly exploring random trees,” presented at the NSV: Numerical Software Verification, Heidelberg, Germany, 2017, vol. 10381, pp. 83–89."},"date_updated":"2021-01-12T08:07:06Z","editor":[{"full_name":"Abate, Alessandro","last_name":"Abate","first_name":"Alessandro"},{"full_name":"Bodo, Sylvie","first_name":"Sylvie","last_name":"Bodo"}],"conference":{"name":"NSV: Numerical Software Verification","end_date":"2017-07-23","location":"Heidelberg, Germany","start_date":"2017-07-22"}}]