[{"citation":{"mla":"Mukhopadhyay, Soham, et al. “Superconductivity from a Melted Insulator in Josephson Junction Arrays.” <i>Nature Physics</i>, vol. 19, Springer Nature, 2023, pp. 1630–35, doi:<a href=\"https://doi.org/10.1038/s41567-023-02161-w\">10.1038/s41567-023-02161-w</a>.","apa":"Mukhopadhyay, S., Senior, J. L., Saez Mollejo, J., Puglia, D., Zemlicka, M., Fink, J. M., &#38; Higginbotham, A. P. (2023). Superconductivity from a melted insulator in Josephson junction arrays. <i>Nature Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41567-023-02161-w\">https://doi.org/10.1038/s41567-023-02161-w</a>","ama":"Mukhopadhyay S, Senior JL, Saez Mollejo J, et al. Superconductivity from a melted insulator in Josephson junction arrays. <i>Nature Physics</i>. 2023;19:1630-1635. doi:<a href=\"https://doi.org/10.1038/s41567-023-02161-w\">10.1038/s41567-023-02161-w</a>","ieee":"S. Mukhopadhyay <i>et al.</i>, “Superconductivity from a melted insulator in Josephson junction arrays,” <i>Nature Physics</i>, vol. 19. Springer Nature, pp. 1630–1635, 2023.","chicago":"Mukhopadhyay, Soham, Jorden L Senior, Jaime Saez Mollejo, Denise Puglia, Martin Zemlicka, Johannes M Fink, and Andrew P Higginbotham. “Superconductivity from a Melted Insulator in Josephson Junction Arrays.” <i>Nature Physics</i>. Springer Nature, 2023. <a href=\"https://doi.org/10.1038/s41567-023-02161-w\">https://doi.org/10.1038/s41567-023-02161-w</a>.","ista":"Mukhopadhyay S, Senior JL, Saez Mollejo J, Puglia D, Zemlicka M, Fink JM, Higginbotham AP. 2023. Superconductivity from a melted insulator in Josephson junction arrays. Nature Physics. 19, 1630–1635.","short":"S. Mukhopadhyay, J.L. Senior, J. Saez Mollejo, D. Puglia, M. Zemlicka, J.M. Fink, A.P. Higginbotham, Nature Physics 19 (2023) 1630–1635."},"date_updated":"2024-01-29T11:27:49Z","author":[{"last_name":"Mukhopadhyay","first_name":"Soham","id":"FDE60288-A89D-11E9-947F-1AF6E5697425","full_name":"Mukhopadhyay, Soham"},{"last_name":"Senior","first_name":"Jorden L","id":"5479D234-2D30-11EA-89CC-40953DDC885E","full_name":"Senior, Jorden L","orcid":"0000-0002-0672-9295"},{"full_name":"Saez Mollejo, Jaime","id":"e0390f72-f6e0-11ea-865d-862393336714","first_name":"Jaime","last_name":"Saez Mollejo"},{"orcid":"0000-0003-1144-2763","full_name":"Puglia, Denise","id":"4D495994-AE37-11E9-AC72-31CAE5697425","first_name":"Denise","last_name":"Puglia"},{"last_name":"Zemlicka","first_name":"Martin","id":"2DCF8DE6-F248-11E8-B48F-1D18A9856A87","full_name":"Zemlicka, Martin"},{"id":"4B591CBA-F248-11E8-B48F-1D18A9856A87","full_name":"Fink, Johannes M","orcid":"0000-0001-8112-028X","first_name":"Johannes M","last_name":"Fink"},{"orcid":"0000-0003-2607-2363","id":"4AD6785A-F248-11E8-B48F-1D18A9856A87","full_name":"Higginbotham, Andrew P","first_name":"Andrew P","last_name":"Higginbotham"}],"publication":"Nature Physics","publication_identifier":{"issn":["1745-2473"],"eissn":["1745-2481"]},"oa":1,"day":"01","project":[{"_id":"0aa3608a-070f-11eb-9043-e9cd8a2bd931","grant_number":"P33692","name":"Cavity electromechanics across a quantum phase transition"},{"_id":"260C2330-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"754411","name":"ISTplus - Postdoctoral Fellowships"},{"_id":"eb9b30ac-77a9-11ec-83b8-871f581d53d2","name":"Protected states of quantum matter"},{"_id":"bd5b4ec5-d553-11ed-ba76-a6eedb083344","name":"Protected states of quantum matter"}],"external_id":{"isi":["001054563800006"]},"title":"Superconductivity from a melted insulator in Josephson junction arrays","has_accepted_license":"1","acknowledged_ssus":[{"_id":"M-Shop"},{"_id":"NanoFab"}],"year":"2023","_id":"14032","ec_funded":1,"date_created":"2023-08-11T07:41:17Z","file":[{"date_updated":"2024-01-29T11:25:38Z","file_id":"14899","relation":"main_file","date_created":"2024-01-29T11:25:38Z","success":1,"file_name":"2023_NaturePhysics_Mukhopadhyay.pdf","access_level":"open_access","creator":"dernst","content_type":"application/pdf","file_size":1977706,"checksum":"1fc86d71bfbf836e221c1e925343adc5"}],"abstract":[{"text":"Arrays of Josephson junctions are governed by a competition between superconductivity and repulsive Coulomb interactions, and are expected to exhibit diverging low-temperature resistance when interactions exceed a critical level. Here we report a study of the transport and microwave response of Josephson arrays with interactions exceeding this level. Contrary to expectations, we observe that the array resistance drops dramatically as the temperature is decreased—reminiscent of superconducting behaviour—and then saturates at low temperature. Applying a magnetic field, we eventually observe a transition to a highly resistive regime. These observations can be understood within a theoretical picture that accounts for the effect of thermal fluctuations on the insulating phase. On the basis of the agreement between experiment and theory, we suggest that apparent superconductivity in our Josephson arrays arises from melting the zero-temperature insulator.","lang":"eng"}],"publication_status":"published","article_type":"original","oa_version":"Published Version","keyword":["General Physics and Astronomy"],"article_processing_charge":"Yes (in subscription journal)","quality_controlled":"1","volume":19,"type":"journal_article","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","file_date_updated":"2024-01-29T11:25:38Z","language":[{"iso":"eng"}],"status":"public","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"doi":"10.1038/s41567-023-02161-w","date_published":"2023-11-01T00:00:00Z","intvolume":"        19","ddc":["530"],"page":"1630-1635","scopus_import":"1","acknowledgement":"We thank D. Haviland, J. Pekola, C. Ciuti, A. Bubis and A. Shnirman for helpful feedback on the paper. This research was supported by the Scientific Service Units of IST Austria through resources provided by the MIBA Machine Shop and the Nanofabrication Facility. Work supported by the Austrian FWF grant P33692-N (S.M., J.S. and A.P.H.), the European Union’s Horizon 2020 Research and Innovation programme under the Marie Skłodowska-Curie Grant Agreement No. 754411 (J.S.) and a NOMIS foundation research grant (J.M.F. and A.P.H.).","department":[{"_id":"GradSch"},{"_id":"AnHi"},{"_id":"JoFi"}],"publisher":"Springer Nature","month":"11","isi":1},{"pmid":1,"date_created":"2023-08-13T22:01:11Z","_id":"14036","year":"2023","article_type":"original","publication_status":"published","abstract":[{"text":"Magic-angle spinning (MAS) nuclear magnetic resonance (NMR) is establishing itself as a powerful method for the characterization of protein dynamics at the atomic scale. We discuss here how R1ρ MAS relaxation dispersion NMR can explore microsecond-to-millisecond motions. Progress in instrumentation, isotope labeling, and pulse sequence design has paved the way for quantitative analyses of even rare structural fluctuations. In addition to isotropic chemical-shift fluctuations exploited in solution-state NMR relaxation dispersion experiments, MAS NMR has a wider arsenal of observables, allowing to see motions even if the exchanging states do not differ in their chemical shifts. We demonstrate the potential of the technique for probing motions in challenging large enzymes, membrane proteins, and protein assemblies.","lang":"eng"}],"file":[{"date_updated":"2024-01-30T12:36:39Z","file_id":"14907","date_created":"2024-01-30T12:36:39Z","relation":"main_file","success":1,"file_name":"2023_CurrentOpinionStrucBio_Napoli.pdf","access_level":"open_access","creator":"dernst","file_size":1231998,"content_type":"application/pdf","checksum":"c850f7ac8a4234319755b672c1df69ae"}],"quality_controlled":"1","article_processing_charge":"Yes (via OA deal)","oa_version":"Published Version","citation":{"short":"F. Napoli, L.M. Becker, P. Schanda, Current Opinion in Structural Biology 82 (2023).","ista":"Napoli F, Becker LM, Schanda P. 2023. Protein dynamics detected by magic-angle spinning relaxation dispersion NMR. Current Opinion in Structural Biology. 82(10), 102660.","chicago":"Napoli, Federico, Lea Marie Becker, and Paul Schanda. “Protein Dynamics Detected by Magic-Angle Spinning Relaxation Dispersion NMR.” <i>Current Opinion in Structural Biology</i>. Elsevier, 2023. <a href=\"https://doi.org/10.1016/j.sbi.2023.102660\">https://doi.org/10.1016/j.sbi.2023.102660</a>.","apa":"Napoli, F., Becker, L. M., &#38; Schanda, P. (2023). Protein dynamics detected by magic-angle spinning relaxation dispersion NMR. <i>Current Opinion in Structural Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.sbi.2023.102660\">https://doi.org/10.1016/j.sbi.2023.102660</a>","ieee":"F. Napoli, L. M. Becker, and P. Schanda, “Protein dynamics detected by magic-angle spinning relaxation dispersion NMR,” <i>Current Opinion in Structural Biology</i>, vol. 82, no. 10. Elsevier, 2023.","ama":"Napoli F, Becker LM, Schanda P. Protein dynamics detected by magic-angle spinning relaxation dispersion NMR. <i>Current Opinion in Structural Biology</i>. 2023;82(10). doi:<a href=\"https://doi.org/10.1016/j.sbi.2023.102660\">10.1016/j.sbi.2023.102660</a>","mla":"Napoli, Federico, et al. “Protein Dynamics Detected by Magic-Angle Spinning Relaxation Dispersion NMR.” <i>Current Opinion in Structural Biology</i>, vol. 82, no. 10, 102660, Elsevier, 2023, doi:<a href=\"https://doi.org/10.1016/j.sbi.2023.102660\">10.1016/j.sbi.2023.102660</a>."},"author":[{"first_name":"Federico","last_name":"Napoli","id":"d42e08e7-f4fc-11eb-af0a-d71e26138f1b","full_name":"Napoli, Federico","orcid":"0000-0002-9043-136X"},{"last_name":"Becker","first_name":"Lea Marie","id":"36336939-eb97-11eb-a6c2-c83f1214ca79","full_name":"Becker, Lea Marie","orcid":"0000-0002-6401-5151"},{"orcid":"0000-0002-9350-7606","id":"7B541462-FAF6-11E9-A490-E8DFE5697425","full_name":"Schanda, Paul","first_name":"Paul","last_name":"Schanda"}],"date_updated":"2024-01-30T12:37:36Z","day":"01","oa":1,"publication_identifier":{"eissn":["1879-033X"],"issn":["0959-440X"]},"publication":"Current Opinion in Structural Biology","external_id":{"isi":["001053616200001"],"pmid":["37536064"]},"title":"Protein dynamics detected by magic-angle spinning relaxation dispersion NMR","project":[{"name":"AlloSpace. The emergence and mechanisms of allostery","_id":"eb9c82eb-77a9-11ec-83b8-aadd536561cf","grant_number":"I05812"}],"issue":"10","article_number":"102660","acknowledgement":"We thank Petra Rovó for critical reading of this manuscript. We acknowledge the Austrian Science Foundation FWF (project AlloSpace, number I5812–B) and funding by the Institute of Science and Technology Austria.","scopus_import":"1","month":"10","publisher":"Elsevier","department":[{"_id":"PaSc"}],"isi":1,"type":"journal_article","volume":82,"file_date_updated":"2024-01-30T12:36:39Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_published":"2023-10-01T00:00:00Z","doi":"10.1016/j.sbi.2023.102660","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"status":"public","language":[{"iso":"eng"}],"ddc":["570"],"intvolume":"        82"},{"_id":"14037","year":"2023","date_created":"2023-08-13T22:01:12Z","ec_funded":1,"pmid":1,"article_processing_charge":"Yes (in subscription journal)","oa_version":"Published Version","quality_controlled":"1","abstract":[{"text":"Traditionally, nuclear spin is not considered to affect biological processes. Recently, this has changed as isotopic fractionation that deviates from classical mass dependence was reported both in vitro and in vivo. In these cases, the isotopic effect correlates with the nuclear magnetic spin. Here, we show nuclear spin effects using stable oxygen isotopes (16O, 17O, and 18O) in two separate setups: an artificial dioxygen production system and biological aquaporin channels in cells. We observe that oxygen dynamics in chiral environments (in particular its transport) depend on nuclear spin, suggesting future applications for controlled isotope separation to be used, for instance, in NMR. To demonstrate the mechanism behind our findings, we formulate theoretical models based on a nuclear-spin-enhanced switch between electronic spin states. Accounting for the role of nuclear spin in biology can provide insights into the role of quantum effects in living systems and help inspire the development of future biotechnology solutions.","lang":"eng"}],"file":[{"access_level":"open_access","creator":"dernst","checksum":"a5ed64788a5acef9b9a300a26fa5a177","file_size":1003092,"content_type":"application/pdf","date_updated":"2023-08-14T07:43:45Z","file_name":"2023_PNAS_Vardi.pdf","file_id":"14047","success":1,"date_created":"2023-08-14T07:43:45Z","relation":"main_file"}],"article_type":"original","publication_status":"published","oa":1,"publication":"Proceedings of the National Academy of Sciences of the United States of America","publication_identifier":{"eissn":["1091-6490"]},"day":"31","author":[{"last_name":"Vardi","first_name":"Ofek","full_name":"Vardi, Ofek"},{"full_name":"Maroudas-Sklare, Naama","first_name":"Naama","last_name":"Maroudas-Sklare"},{"full_name":"Kolodny, Yuval","first_name":"Yuval","last_name":"Kolodny"},{"full_name":"Volosniev, Artem","id":"37D278BC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-0393-5525","first_name":"Artem","last_name":"Volosniev"},{"full_name":"Saragovi, Amijai","last_name":"Saragovi","first_name":"Amijai"},{"full_name":"Galili, Nir","first_name":"Nir","last_name":"Galili"},{"first_name":"Stav","last_name":"Ferrera","full_name":"Ferrera, Stav"},{"orcid":"0000-0001-9666-3543","full_name":"Ghazaryan, Areg","id":"4AF46FD6-F248-11E8-B48F-1D18A9856A87","first_name":"Areg","last_name":"Ghazaryan"},{"first_name":"Nir","last_name":"Yuran","full_name":"Yuran, Nir"},{"full_name":"Affek, Hagit P.","first_name":"Hagit P.","last_name":"Affek"},{"first_name":"Boaz","last_name":"Luz","full_name":"Luz, Boaz"},{"first_name":"Yonaton","last_name":"Goldsmith","full_name":"Goldsmith, Yonaton"},{"full_name":"Keren, Nir","last_name":"Keren","first_name":"Nir"},{"full_name":"Yochelis, Shira","last_name":"Yochelis","first_name":"Shira"},{"full_name":"Halevy, Itay","first_name":"Itay","last_name":"Halevy"},{"first_name":"Mikhail","last_name":"Lemeshko","full_name":"Lemeshko, Mikhail","id":"37CB05FA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6990-7802"},{"full_name":"Paltiel, Yossi","first_name":"Yossi","last_name":"Paltiel"}],"citation":{"mla":"Vardi, Ofek, et al. “Nuclear Spin Effects in Biological Processes.” <i>Proceedings of the National Academy of Sciences of the United States of America</i>, vol. 120, no. 32, e2300828120, National Academy of Sciences, 2023, doi:<a href=\"https://doi.org/10.1073/pnas.2300828120\">10.1073/pnas.2300828120</a>.","ieee":"O. Vardi <i>et al.</i>, “Nuclear spin effects in biological processes,” <i>Proceedings of the National Academy of Sciences of the United States of America</i>, vol. 120, no. 32. National Academy of Sciences, 2023.","ama":"Vardi O, Maroudas-Sklare N, Kolodny Y, et al. Nuclear spin effects in biological processes. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. 2023;120(32). doi:<a href=\"https://doi.org/10.1073/pnas.2300828120\">10.1073/pnas.2300828120</a>","apa":"Vardi, O., Maroudas-Sklare, N., Kolodny, Y., Volosniev, A., Saragovi, A., Galili, N., … Paltiel, Y. (2023). Nuclear spin effects in biological processes. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.2300828120\">https://doi.org/10.1073/pnas.2300828120</a>","chicago":"Vardi, Ofek, Naama Maroudas-Sklare, Yuval Kolodny, Artem Volosniev, Amijai Saragovi, Nir Galili, Stav Ferrera, et al. “Nuclear Spin Effects in Biological Processes.” <i>Proceedings of the National Academy of Sciences of the United States of America</i>. National Academy of Sciences, 2023. <a href=\"https://doi.org/10.1073/pnas.2300828120\">https://doi.org/10.1073/pnas.2300828120</a>.","ista":"Vardi O, Maroudas-Sklare N, Kolodny Y, Volosniev A, Saragovi A, Galili N, Ferrera S, Ghazaryan A, Yuran N, Affek HP, Luz B, Goldsmith Y, Keren N, Yochelis S, Halevy I, Lemeshko M, Paltiel Y. 2023. Nuclear spin effects in biological processes. Proceedings of the National Academy of Sciences of the United States of America. 120(32), e2300828120.","short":"O. Vardi, N. Maroudas-Sklare, Y. Kolodny, A. Volosniev, A. Saragovi, N. Galili, S. Ferrera, A. Ghazaryan, N. Yuran, H.P. Affek, B. Luz, Y. Goldsmith, N. Keren, S. Yochelis, I. Halevy, M. Lemeshko, Y. Paltiel, Proceedings of the National Academy of Sciences of the United States of America 120 (2023)."},"date_updated":"2023-10-17T11:45:25Z","article_number":"e2300828120","issue":"32","has_accepted_license":"1","external_id":{"pmid":["37523549"]},"title":"Nuclear spin effects in biological processes","project":[{"_id":"2688CF98-B435-11E9-9278-68D0E5697425","grant_number":"801770","call_identifier":"H2020","name":"Angulon: physics and applications of a new quasiparticle"}],"scopus_import":"1","acknowledgement":"N.M.-S. acknowledges the support of the Ministry of Energy, Israel, as part of the scholarship program for graduate students in the fields of energy. M.L. acknowledges support by the European Research Council (ERC) Starting Grant No. 801770 (ANGULON). Y.P. acknowledges the support of the Ministry of Innovation, Science and Technology, Israel Grant No. 1001593872. Y.P acknowledges the support of the BSF-NSF 094 Grant No. 2022503.","license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","month":"07","publisher":"National Academy of Sciences","department":[{"_id":"MiLe"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","file_date_updated":"2023-08-14T07:43:45Z","volume":120,"type":"journal_article","ddc":["530"],"intvolume":"       120","status":"public","tmp":{"image":"/images/cc_by_nc_nd.png","short":"CC BY-NC-ND (4.0)","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode"},"language":[{"iso":"eng"}],"date_published":"2023-07-31T00:00:00Z","doi":"10.1073/pnas.2300828120"},{"department":[{"_id":"MaLo"}],"publisher":"Elsevier","month":"08","isi":1,"page":"1315-1332","scopus_import":"1","acknowledgement":"We acknowledge funding from the Austrian Science Fund (FWF F79, P32814-B, and P35061-B to S.M.; P34607-B to M.L.; and P30584-B and P33066-B to T.A.L.) and the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement no. 101045340 to M.L.). We are grateful for comments on the manuscript by Justyna Sawa-Makarska, Verena Baumann, Marko Kojic, Philipp Radler, Ronja Reinhardt, and Sumire Antonioli.","language":[{"iso":"eng"}],"status":"public","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"doi":"10.1016/j.devcel.2023.06.001","date_published":"2023-08-07T00:00:00Z","ddc":["570"],"intvolume":"        58","volume":58,"type":"journal_article","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","file_date_updated":"2023-08-14T07:57:55Z","file":[{"date_updated":"2023-08-14T07:57:55Z","file_name":"2023_DevelopmentalCell_Leonard.pdf","file_id":"14049","date_created":"2023-08-14T07:57:55Z","success":1,"relation":"main_file","access_level":"open_access","creator":"dernst","checksum":"d8c5dc97cd40c26da2ec98ae723ab368","file_size":3184217,"content_type":"application/pdf"}],"abstract":[{"lang":"eng","text":"Membranes are essential for life. They act as semi-permeable boundaries that define cells and organelles. In addition, their surfaces actively participate in biochemical reaction networks, where they confine proteins, align reaction partners, and directly control enzymatic activities. Membrane-localized reactions shape cellular membranes, define the identity of organelles, compartmentalize biochemical processes, and can even be the source of signaling gradients that originate at the plasma membrane and reach into the cytoplasm and nucleus. The membrane surface is, therefore, an essential platform upon which myriad cellular processes are scaffolded. In this review, we summarize our current understanding of the biophysics and biochemistry of membrane-localized reactions with particular focus on insights derived from reconstituted and cellular systems. We discuss how the interplay of cellular factors results in their self-organization, condensation, assembly, and activity, and the emergent properties derived from them."}],"publication_status":"published","article_type":"original","oa_version":"Published Version","article_processing_charge":"Yes (via OA deal)","quality_controlled":"1","year":"2023","_id":"14039","pmid":1,"date_created":"2023-08-13T22:01:12Z","project":[{"_id":"fc38323b-9c52-11eb-aca3-ff8afb4a011d","grant_number":"P34607","name":"Understanding bacterial cell division by in vitro\r\nreconstitution"},{"grant_number":"101045340","_id":"bd6ae2ca-d553-11ed-ba76-a4aa239da5ee","name":"Synthetic and structural biology of Rab GTPase networks"}],"title":"The membrane surface as a platform that organizes cellular and biochemical processes","external_id":{"pmid":["37419118"],"isi":["001059110400001"]},"issue":"15","has_accepted_license":"1","citation":{"mla":"Leonard, Thomas A., et al. “The Membrane Surface as a Platform That Organizes Cellular and Biochemical Processes.” <i>Developmental Cell</i>, vol. 58, no. 15, Elsevier, 2023, pp. 1315–32, doi:<a href=\"https://doi.org/10.1016/j.devcel.2023.06.001\">10.1016/j.devcel.2023.06.001</a>.","ama":"Leonard TA, Loose M, Martens S. The membrane surface as a platform that organizes cellular and biochemical processes. <i>Developmental Cell</i>. 2023;58(15):1315-1332. doi:<a href=\"https://doi.org/10.1016/j.devcel.2023.06.001\">10.1016/j.devcel.2023.06.001</a>","ieee":"T. A. Leonard, M. Loose, and S. Martens, “The membrane surface as a platform that organizes cellular and biochemical processes,” <i>Developmental Cell</i>, vol. 58, no. 15. Elsevier, pp. 1315–1332, 2023.","apa":"Leonard, T. A., Loose, M., &#38; Martens, S. (2023). The membrane surface as a platform that organizes cellular and biochemical processes. <i>Developmental Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.devcel.2023.06.001\">https://doi.org/10.1016/j.devcel.2023.06.001</a>","chicago":"Leonard, Thomas A., Martin Loose, and Sascha Martens. “The Membrane Surface as a Platform That Organizes Cellular and Biochemical Processes.” <i>Developmental Cell</i>. Elsevier, 2023. <a href=\"https://doi.org/10.1016/j.devcel.2023.06.001\">https://doi.org/10.1016/j.devcel.2023.06.001</a>.","ista":"Leonard TA, Loose M, Martens S. 2023. The membrane surface as a platform that organizes cellular and biochemical processes. Developmental Cell. 58(15), 1315–1332.","short":"T.A. Leonard, M. Loose, S. Martens, Developmental Cell 58 (2023) 1315–1332."},"date_updated":"2023-12-13T12:09:20Z","author":[{"full_name":"Leonard, Thomas A.","last_name":"Leonard","first_name":"Thomas A."},{"last_name":"Loose","first_name":"Martin","full_name":"Loose, Martin","id":"462D4284-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-7309-9724"},{"first_name":"Sascha","last_name":"Martens","full_name":"Martens, Sascha"}],"publication":"Developmental Cell","publication_identifier":{"issn":["1534-5807"],"eissn":["1878-1551"]},"oa":1,"day":"07"},{"isi":1,"month":"08","department":[{"_id":"LeSa"}],"publisher":"Springer Nature","acknowledgement":"P.J.N. and J.W.M. are grateful for the support of the Biotechnology & Biological Sciences Research Council (awards BB/L003260/1 and BB/P00931X/1). J. Knoppová, R.S. and J. Komenda were supported by the Czech Science Foundation (project 19-29225X) and by ERC project Photoredesign (no. 854126) and L.A.S. was supported by the Scientific Service Units (SSU) of IST Austria through resources provided by the Electron Microscopy Facility (EMF), the Life Science Facility (LSF) and the IST high-performance computing cluster.","scopus_import":"1","intvolume":"        14","ddc":["570"],"date_published":"2023-08-04T00:00:00Z","doi":"10.1038/s41467-023-40388-6","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"status":"public","language":[{"iso":"eng"}],"file_date_updated":"2023-08-14T07:01:12Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"journal_article","volume":14,"quality_controlled":"1","article_processing_charge":"Yes","oa_version":"Published Version","article_type":"original","publication_status":"published","abstract":[{"text":"Robust oxygenic photosynthesis requires a suite of accessory factors to ensure efficient assembly and repair of the oxygen-evolving photosystem two (PSII) complex. The highly conserved Ycf48 assembly factor binds to the newly synthesized D1 reaction center polypeptide and promotes the initial steps of PSII assembly, but its binding site is unclear. Here we use cryo-electron microscopy to determine the structure of a cyanobacterial PSII D1/D2 reaction center assembly complex with Ycf48 attached. Ycf48, a 7-bladed beta propeller, binds to the amino-acid residues of D1 that ultimately ligate the water-oxidising Mn4CaO5 cluster, thereby preventing the premature binding of Mn2+ and Ca2+ ions and protecting the site from damage. Interactions with D2 help explain how Ycf48 promotes assembly of the D1/D2 complex. Overall, our work provides valuable insights into the early stages of PSII assembly and the structural changes that create the binding site for the Mn4CaO5 cluster.","lang":"eng"}],"file":[{"relation":"main_file","success":1,"date_created":"2023-08-14T07:01:12Z","file_id":"14044","file_name":"2023_NatureComm_Zhao.pdf","date_updated":"2023-08-14T07:01:12Z","content_type":"application/pdf","file_size":2315325,"checksum":"3b9043df3d51c300f9be95eac3ff9d0b","creator":"dernst","access_level":"open_access"}],"date_created":"2023-08-13T22:01:13Z","_id":"14040","year":"2023","acknowledged_ssus":[{"_id":"EM-Fac"},{"_id":"LifeSc"},{"_id":"ScienComp"}],"has_accepted_license":"1","article_number":"4681","title":"The Ycf48 accessory factor occupies the site of the oxygen-evolving manganese cluster during photosystem II biogenesis","external_id":{"isi":["001042606700004"]},"day":"04","oa":1,"publication":"Nature Communications","publication_identifier":{"eissn":["2041-1723"]},"author":[{"full_name":"Zhao, Ziyu","first_name":"Ziyu","last_name":"Zhao"},{"first_name":"Irene","last_name":"Vercellino","full_name":"Vercellino, Irene","id":"3ED6AF16-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5618-3449"},{"full_name":"Knoppová, Jana","last_name":"Knoppová","first_name":"Jana"},{"first_name":"Roman","last_name":"Sobotka","full_name":"Sobotka, Roman"},{"last_name":"Murray","first_name":"James W.","full_name":"Murray, James W."},{"full_name":"Nixon, Peter J.","first_name":"Peter J.","last_name":"Nixon"},{"first_name":"Leonid A","last_name":"Sazanov","orcid":"0000-0002-0977-7989","id":"338D39FE-F248-11E8-B48F-1D18A9856A87","full_name":"Sazanov, Leonid A"},{"first_name":"Josef","last_name":"Komenda","full_name":"Komenda, Josef"}],"date_updated":"2023-12-13T12:06:56Z","citation":{"chicago":"Zhao, Ziyu, Irene Vercellino, Jana Knoppová, Roman Sobotka, James W. Murray, Peter J. Nixon, Leonid A Sazanov, and Josef Komenda. “The Ycf48 Accessory Factor Occupies the Site of the Oxygen-Evolving Manganese Cluster during Photosystem II Biogenesis.” <i>Nature Communications</i>. Springer Nature, 2023. <a href=\"https://doi.org/10.1038/s41467-023-40388-6\">https://doi.org/10.1038/s41467-023-40388-6</a>.","ista":"Zhao Z, Vercellino I, Knoppová J, Sobotka R, Murray JW, Nixon PJ, Sazanov LA, Komenda J. 2023. The Ycf48 accessory factor occupies the site of the oxygen-evolving manganese cluster during photosystem II biogenesis. Nature Communications. 14, 4681.","mla":"Zhao, Ziyu, et al. “The Ycf48 Accessory Factor Occupies the Site of the Oxygen-Evolving Manganese Cluster during Photosystem II Biogenesis.” <i>Nature Communications</i>, vol. 14, 4681, Springer Nature, 2023, doi:<a href=\"https://doi.org/10.1038/s41467-023-40388-6\">10.1038/s41467-023-40388-6</a>.","apa":"Zhao, Z., Vercellino, I., Knoppová, J., Sobotka, R., Murray, J. W., Nixon, P. J., … Komenda, J. (2023). The Ycf48 accessory factor occupies the site of the oxygen-evolving manganese cluster during photosystem II biogenesis. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-023-40388-6\">https://doi.org/10.1038/s41467-023-40388-6</a>","ama":"Zhao Z, Vercellino I, Knoppová J, et al. The Ycf48 accessory factor occupies the site of the oxygen-evolving manganese cluster during photosystem II biogenesis. <i>Nature Communications</i>. 2023;14. doi:<a href=\"https://doi.org/10.1038/s41467-023-40388-6\">10.1038/s41467-023-40388-6</a>","ieee":"Z. Zhao <i>et al.</i>, “The Ycf48 accessory factor occupies the site of the oxygen-evolving manganese cluster during photosystem II biogenesis,” <i>Nature Communications</i>, vol. 14. Springer Nature, 2023.","short":"Z. Zhao, I. Vercellino, J. Knoppová, R. Sobotka, J.W. Murray, P.J. Nixon, L.A. Sazanov, J. Komenda, Nature Communications 14 (2023)."}},{"title":"3D cell segregation geometry and dynamics are governed by tissue surface tension regulation","external_id":{"pmid":["37542157"],"isi":["001042544100001"]},"has_accepted_license":"1","article_number":"817","date_updated":"2023-12-13T12:07:33Z","author":[{"last_name":"Méhes","first_name":"Elod","full_name":"Méhes, Elod"},{"first_name":"Enys","last_name":"Mones","full_name":"Mones, Enys"},{"full_name":"Varga, Máté","last_name":"Varga","first_name":"Máté"},{"full_name":"Zsigmond, Áron","last_name":"Zsigmond","first_name":"Áron"},{"full_name":"Biri-Kovács, Beáta","first_name":"Beáta","last_name":"Biri-Kovács"},{"last_name":"Nyitray","first_name":"László","full_name":"Nyitray, László"},{"last_name":"Barone","first_name":"Vanessa","full_name":"Barone, Vanessa","id":"419EECCC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-2676-3367"},{"last_name":"Krens","first_name":"Gabriel","id":"2B819732-F248-11E8-B48F-1D18A9856A87","full_name":"Krens, Gabriel","orcid":"0000-0003-4761-5996"},{"first_name":"Carl-Philipp J","last_name":"Heisenberg","orcid":"0000-0002-0912-4566","full_name":"Heisenberg, Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Vicsek, Tamás","last_name":"Vicsek","first_name":"Tamás"}],"citation":{"mla":"Méhes, Elod, et al. “3D Cell Segregation Geometry and Dynamics Are Governed by Tissue Surface Tension Regulation.” <i>Communications Biology</i>, vol. 6, 817, Springer Nature, 2023, doi:<a href=\"https://doi.org/10.1038/s42003-023-05181-7\">10.1038/s42003-023-05181-7</a>.","ieee":"E. Méhes <i>et al.</i>, “3D cell segregation geometry and dynamics are governed by tissue surface tension regulation,” <i>Communications Biology</i>, vol. 6. Springer Nature, 2023.","ama":"Méhes E, Mones E, Varga M, et al. 3D cell segregation geometry and dynamics are governed by tissue surface tension regulation. <i>Communications Biology</i>. 2023;6. doi:<a href=\"https://doi.org/10.1038/s42003-023-05181-7\">10.1038/s42003-023-05181-7</a>","apa":"Méhes, E., Mones, E., Varga, M., Zsigmond, Á., Biri-Kovács, B., Nyitray, L., … Vicsek, T. (2023). 3D cell segregation geometry and dynamics are governed by tissue surface tension regulation. <i>Communications Biology</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s42003-023-05181-7\">https://doi.org/10.1038/s42003-023-05181-7</a>","chicago":"Méhes, Elod, Enys Mones, Máté Varga, Áron Zsigmond, Beáta Biri-Kovács, László Nyitray, Vanessa Barone, Gabriel Krens, Carl-Philipp J Heisenberg, and Tamás Vicsek. “3D Cell Segregation Geometry and Dynamics Are Governed by Tissue Surface Tension Regulation.” <i>Communications Biology</i>. Springer Nature, 2023. <a href=\"https://doi.org/10.1038/s42003-023-05181-7\">https://doi.org/10.1038/s42003-023-05181-7</a>.","ista":"Méhes E, Mones E, Varga M, Zsigmond Á, Biri-Kovács B, Nyitray L, Barone V, Krens G, Heisenberg C-PJ, Vicsek T. 2023. 3D cell segregation geometry and dynamics are governed by tissue surface tension regulation. Communications Biology. 6, 817.","short":"E. Méhes, E. Mones, M. Varga, Á. Zsigmond, B. Biri-Kovács, L. Nyitray, V. Barone, G. Krens, C.-P.J. Heisenberg, T. Vicsek, Communications Biology 6 (2023)."},"day":"04","oa":1,"publication_identifier":{"eissn":["2399-3642"]},"publication":"Communications Biology","publication_status":"published","article_type":"original","abstract":[{"lang":"eng","text":"Tissue morphogenesis and patterning during development involve the segregation of cell types. Segregation is driven by differential tissue surface tensions generated by cell types through controlling cell-cell contact formation by regulating adhesion and actomyosin contractility-based cellular cortical tensions. We use vertebrate tissue cell types and zebrafish germ layer progenitors as in vitro models of 3-dimensional heterotypic segregation and developed a quantitative analysis of their dynamics based on 3D time-lapse microscopy. We show that general inhibition of actomyosin contractility by the Rho kinase inhibitor Y27632 delays segregation. Cell type-specific inhibition of non-muscle myosin2 activity by overexpression of myosin assembly inhibitor S100A4 reduces tissue surface tension, manifested in decreased compaction during aggregation and inverted geometry observed during segregation. The same is observed when we express a constitutively active Rho kinase isoform to ubiquitously keep actomyosin contractility high at cell-cell and cell-medium interfaces and thus overriding the interface-specific regulation of cortical tensions. Tissue surface tension regulation can become an effective tool in tissue engineering."}],"file":[{"creator":"dernst","access_level":"open_access","content_type":"application/pdf","file_size":10181997,"checksum":"1f9324f736bdbb76426b07736651c4cd","date_updated":"2023-08-14T07:17:36Z","relation":"main_file","success":1,"date_created":"2023-08-14T07:17:36Z","file_id":"14045","file_name":"2023_CommBiology_Mehes.pdf"}],"quality_controlled":"1","article_processing_charge":"Yes","oa_version":"Published Version","date_created":"2023-08-13T22:01:13Z","pmid":1,"_id":"14041","year":"2023","date_published":"2023-08-04T00:00:00Z","doi":"10.1038/s42003-023-05181-7","status":"public","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"language":[{"iso":"eng"}],"ddc":["570"],"intvolume":"         6","type":"journal_article","volume":6,"file_date_updated":"2023-08-14T07:17:36Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","month":"08","department":[{"_id":"CaHe"},{"_id":"Bio"}],"publisher":"Springer Nature","isi":1,"acknowledgement":"We thank Marton Gulyas (ELTE Eötvös University) for development of videomicroscopy experiment manager and image analysis software. Authors are grateful to Gabor Forgacs (University of Missouri) for critical reading of earlier versions of this manuscript as well as to Zsuzsa Akos and Andras Czirok (ELTE Eötvös University) for fruitful discussions. This work was supported by EU FP7, ERC COLLMOT Project No 227878 to TV, the National Research Development and Innovation Fund of Hungary, K119359 and also Project No 2018-1.2.1-NKP-2018-00005 to LN. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 955576. MV was supported by the Ja´nos Bolyai Fellowship of the Hungarian Academy of Sciences.\r\nOpen access funding provided by Eötvös Loránd University.","scopus_import":"1"},{"arxiv":1,"acknowledgement":"M. Bulíček and J. Málek acknowledge the support of the project No. 20-11027X financed by the Czech Science foundation (GAČR). M. Bulíček and J. Málek are members of the Nečas Center for Mathematical Modelling.\r\nOpen access publishing supported by the National Technical Library in Prague.","scopus_import":"1","month":"08","department":[{"_id":"JuFi"}],"publisher":"Springer Nature","isi":1,"type":"journal_article","volume":25,"file_date_updated":"2023-08-14T07:24:17Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_published":"2023-08-01T00:00:00Z","doi":"10.1007/s00021-023-00803-w","status":"public","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"language":[{"iso":"eng"}],"intvolume":"        25","ddc":["510"],"date_created":"2023-08-13T22:01:13Z","_id":"14042","year":"2023","article_type":"original","publication_status":"published","abstract":[{"lang":"eng","text":"Long-time and large-data existence of weak solutions for initial- and boundary-value problems concerning three-dimensional flows of incompressible fluids is nowadays available not only for Navier–Stokes fluids but also for various fluid models where the relation between the Cauchy stress tensor and the symmetric part of the velocity gradient is nonlinear. The majority of such studies however concerns models where such a dependence is explicit (the stress is a function of the velocity gradient), which makes the class of studied models unduly restrictive. The same concerns boundary conditions, or more precisely the slipping mechanisms on the boundary, where the no-slip is still the most preferred condition considered in the literature. Our main objective is to develop a robust mathematical theory for unsteady internal flows of implicitly constituted incompressible fluids with implicit relations between the tangential projections of the velocity and the normal traction on the boundary. The theory covers numerous rheological models used in chemistry, biorheology, polymer and food industry as well as in geomechanics. It also includes, as special cases, nonlinear slip as well as stick–slip boundary conditions. Unlike earlier studies, the conditions characterizing admissible classes of constitutive equations are expressed by means of tools of elementary calculus. In addition, a fully constructive proof (approximation scheme) is incorporated. Finally, we focus on the question of uniqueness of such weak solutions."}],"file":[{"access_level":"open_access","creator":"dernst","content_type":"application/pdf","file_size":845748,"checksum":"c549cd8f0dd02ed60477a05ca045f481","date_updated":"2023-08-14T07:24:17Z","file_id":"14046","success":1,"date_created":"2023-08-14T07:24:17Z","relation":"main_file","file_name":"2023_JourMathFluidMech_Bulicek.pdf"}],"quality_controlled":"1","article_processing_charge":"Yes (via OA deal)","oa_version":"Published Version","author":[{"full_name":"Bulíček, Miroslav","first_name":"Miroslav","last_name":"Bulíček"},{"full_name":"Málek, Josef","first_name":"Josef","last_name":"Málek"},{"full_name":"Maringová, Erika","id":"dbabca31-66eb-11eb-963a-fb9c22c880b4","first_name":"Erika","last_name":"Maringová"}],"date_updated":"2023-12-13T12:08:08Z","citation":{"short":"M. Bulíček, J. Málek, E. Maringová, Journal of Mathematical Fluid Mechanics 25 (2023).","ista":"Bulíček M, Málek J, Maringová E. 2023. On unsteady internal flows of incompressible fluids characterized by implicit constitutive equations in the bulk and on the boundary. Journal of Mathematical Fluid Mechanics. 25(3), 72.","chicago":"Bulíček, Miroslav, Josef Málek, and Erika Maringová. “On Unsteady Internal Flows of Incompressible Fluids Characterized by Implicit Constitutive Equations in the Bulk and on the Boundary.” <i>Journal of Mathematical Fluid Mechanics</i>. Springer Nature, 2023. <a href=\"https://doi.org/10.1007/s00021-023-00803-w\">https://doi.org/10.1007/s00021-023-00803-w</a>.","ama":"Bulíček M, Málek J, Maringová E. On unsteady internal flows of incompressible fluids characterized by implicit constitutive equations in the bulk and on the boundary. <i>Journal of Mathematical Fluid Mechanics</i>. 2023;25(3). doi:<a href=\"https://doi.org/10.1007/s00021-023-00803-w\">10.1007/s00021-023-00803-w</a>","apa":"Bulíček, M., Málek, J., &#38; Maringová, E. (2023). On unsteady internal flows of incompressible fluids characterized by implicit constitutive equations in the bulk and on the boundary. <i>Journal of Mathematical Fluid Mechanics</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s00021-023-00803-w\">https://doi.org/10.1007/s00021-023-00803-w</a>","ieee":"M. Bulíček, J. Málek, and E. Maringová, “On unsteady internal flows of incompressible fluids characterized by implicit constitutive equations in the bulk and on the boundary,” <i>Journal of Mathematical Fluid Mechanics</i>, vol. 25, no. 3. Springer Nature, 2023.","mla":"Bulíček, Miroslav, et al. “On Unsteady Internal Flows of Incompressible Fluids Characterized by Implicit Constitutive Equations in the Bulk and on the Boundary.” <i>Journal of Mathematical Fluid Mechanics</i>, vol. 25, no. 3, 72, Springer Nature, 2023, doi:<a href=\"https://doi.org/10.1007/s00021-023-00803-w\">10.1007/s00021-023-00803-w</a>."},"day":"01","oa":1,"publication_identifier":{"eissn":["1422-6952"],"issn":["1422-6928"]},"publication":"Journal of Mathematical Fluid Mechanics","title":"On unsteady internal flows of incompressible fluids characterized by implicit constitutive equations in the bulk and on the boundary","external_id":{"arxiv":["2301.12834"],"isi":["001040354900001"]},"has_accepted_license":"1","issue":"3","article_number":"72"},{"arxiv":1,"page":"2680-3716","acknowledgement":"Monika Henzinger was supported by funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme Grant agreement No. 101019564 “The Design of Modern Fully Dynamic Data Structures (MoDynStruct)” and from the Austrian Science Fund (FWF) project “Fast Algorithms for a Reactive Network Layer (ReactNet)”, P 33775-N, with additional funding from the netidee SCIENCE Stiftung, 2020–2024. Billy Jin was Supported in part by NSERC fellowship PGSD3-532673-2019 and NSF grant CCF-2007009. Richard Peng was supported in part by an NSERC Discovery Grant and NSF grant CCF-1846218. David P. Williamson was supported in part by NSF grant CCF-2007009.","scopus_import":"1","month":"12","publisher":"Springer Nature","department":[{"_id":"MoHe"}],"main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2010.16316"}],"isi":1,"type":"journal_article","volume":85,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_published":"2023-12-01T00:00:00Z","doi":"10.1007/s00453-023-01154-8","status":"public","language":[{"iso":"eng"}],"intvolume":"        85","date_created":"2023-08-13T22:01:13Z","ec_funded":1,"_id":"14043","year":"2023","publication_status":"published","article_type":"original","abstract":[{"text":"Over the last two decades, a significant line of work in theoretical algorithms has made progress in solving linear systems of the form Lx=b, where L is the Laplacian matrix of a weighted graph with weights w(i,j)>0 on the edges. The solution x of the linear system can be interpreted as the potentials of an electrical flow in which the resistance on edge (i, j) is 1/w(i, j). Kelner et al. (in: Proceedings of the 45th Annual ACM Symposium on the Theory of Computing, pp 911–920, 2013. https://doi.org/10.1145/2488608.2488724) give a combinatorial, near-linear time algorithm that maintains the Kirchoff Current Law, and gradually enforces the Kirchoff Potential Law by updating flows around cycles (cycle toggling). In this paper, we consider a dual version of the algorithm that maintains the Kirchoff Potential Law, and gradually enforces the Kirchoff Current Law by cut toggling: each iteration updates all potentials on one side of a fundamental cut of a spanning tree by the same amount. We prove that this dual algorithm also runs in a near-linear number of iterations. We show, however, that if we abstract cut toggling as a natural data structure problem, this problem can be reduced to the online vector–matrix-vector problem, which has been conjectured to be difficult for dynamic algorithms (Henzinger et al., in: Proceedings of the 47th Annual ACM Symposium on the Theory of Computing, pp 21–30, 2015. https://doi.org/10.1145/2746539.2746609). The conjecture implies that the data structure does not have an O(n1−ϵ) time algorithm for any ϵ>0, and thus a straightforward implementation of the cut-toggling algorithm requires essentially linear time per iteration. To circumvent the lower bound, we batch update steps, and perform them simultaneously instead of sequentially. An appropriate choice of batching leads to an O˜(m1.5) time cut-toggling algorithm for solving Laplacian systems. Furthermore, we show that if we sparsify the graph and call our algorithm recursively on the Laplacian system implied by batching and sparsifying, we can reduce the running time to O(m1+ϵ) for any ϵ>0. Thus, the dual cut-toggling algorithm can achieve (almost) the same running time as its primal cycle-toggling counterpart.","lang":"eng"}],"quality_controlled":"1","article_processing_charge":"No","oa_version":"Preprint","citation":{"chicago":"Henzinger, Monika H, Billy Jin, Richard Peng, and David P. Williamson. “A Combinatorial Cut-Toggling Algorithm for Solving Laplacian Linear Systems.” <i>Algorithmica</i>. Springer Nature, 2023. <a href=\"https://doi.org/10.1007/s00453-023-01154-8\">https://doi.org/10.1007/s00453-023-01154-8</a>.","ista":"Henzinger MH, Jin B, Peng R, Williamson DP. 2023. A combinatorial cut-toggling algorithm for solving Laplacian linear systems. Algorithmica. 85, 2680–3716.","mla":"Henzinger, Monika H., et al. “A Combinatorial Cut-Toggling Algorithm for Solving Laplacian Linear Systems.” <i>Algorithmica</i>, vol. 85, Springer Nature, 2023, pp. 2680–3716, doi:<a href=\"https://doi.org/10.1007/s00453-023-01154-8\">10.1007/s00453-023-01154-8</a>.","ieee":"M. H. Henzinger, B. Jin, R. Peng, and D. P. Williamson, “A combinatorial cut-toggling algorithm for solving Laplacian linear systems,” <i>Algorithmica</i>, vol. 85. Springer Nature, pp. 2680–3716, 2023.","ama":"Henzinger MH, Jin B, Peng R, Williamson DP. A combinatorial cut-toggling algorithm for solving Laplacian linear systems. <i>Algorithmica</i>. 2023;85:2680-3716. doi:<a href=\"https://doi.org/10.1007/s00453-023-01154-8\">10.1007/s00453-023-01154-8</a>","apa":"Henzinger, M. H., Jin, B., Peng, R., &#38; Williamson, D. P. (2023). A combinatorial cut-toggling algorithm for solving Laplacian linear systems. <i>Algorithmica</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s00453-023-01154-8\">https://doi.org/10.1007/s00453-023-01154-8</a>","short":"M.H. Henzinger, B. Jin, R. Peng, D.P. Williamson, Algorithmica 85 (2023) 2680–3716."},"author":[{"last_name":"Henzinger","first_name":"Monika H","orcid":"0000-0002-5008-6530","full_name":"Henzinger, Monika H","id":"540c9bbd-f2de-11ec-812d-d04a5be85630"},{"first_name":"Billy","last_name":"Jin","full_name":"Jin, Billy"},{"full_name":"Peng, Richard","first_name":"Richard","last_name":"Peng"},{"first_name":"David P.","last_name":"Williamson","full_name":"Williamson, David P."}],"date_updated":"2024-01-30T12:33:10Z","day":"01","oa":1,"publication":"Algorithmica","publication_identifier":{"eissn":["1432-0541"],"issn":["0178-4617"]},"title":"A combinatorial cut-toggling algorithm for solving Laplacian linear systems","external_id":{"arxiv":["2010.16316"],"isi":["001041254900002"]},"project":[{"name":"The design and evaluation of modern fully dynamic data structures","call_identifier":"H2020","grant_number":"101019564","_id":"bd9ca328-d553-11ed-ba76-dc4f890cfe62"},{"name":"Fast Algorithms for a Reactive Network Layer","_id":"bd9e3a2e-d553-11ed-ba76-8aa684ce17fe","grant_number":"P33775 "}]},{"oa_version":"Published Version","article_processing_charge":"No","related_material":{"record":[{"relation":"research_data","status":"public","id":"9803"},{"id":"12933","status":"public","relation":"research_data"},{"status":"public","id":"6831","relation":"part_of_dissertation"},{"relation":"part_of_dissertation","id":"14077","status":"public"}]},"publication_status":"published","file":[{"date_updated":"2023-08-17T06:55:24Z","file_name":"Thesis_latex_forpdfa.zip","file_id":"14075","relation":"source_file","date_created":"2023-08-16T18:15:17Z","access_level":"closed","creator":"gpuixeus","checksum":"4e44e169f2724ee8c9324cd60bcc2b71","file_size":10891454,"content_type":"application/zip"},{"date_updated":"2023-08-18T10:47:55Z","success":1,"date_created":"2023-08-18T10:47:55Z","relation":"main_file","file_id":"14079","file_name":"PhDThesis_PuixeuG.pdf","creator":"gpuixeus","access_level":"open_access","file_size":19856686,"content_type":"application/pdf","checksum":"e10b04cd8f3fecc0d9ef6e6868b6e1e8"}],"abstract":[{"text":"Females and males across species are subject to divergent selective pressures arising\r\nfrom di↵erent reproductive interests and ecological niches. This often translates into a\r\nintricate array of sex-specific natural and sexual selection on traits that have a shared\r\ngenetic basis between both sexes, causing a genetic sexual conflict. The resolution of\r\nthis conflict mostly relies on the evolution of sex-specific expression of the shared genes,\r\nleading to phenotypic sexual dimorphism. Such sex-specific gene expression is thought\r\nto evolve via modifications of the genetic networks ultimately linked to sex-determining\r\ntranscription factors. Although much empirical and theoretical evidence supports this\r\nstandard picture of the molecular basis of sexual conflict resolution, there still are a\r\nfew open questions regarding the complex array of selective forces driving phenotypic\r\ndi↵erentiation between the sexes, as well as the molecular mechanisms underlying sexspecific adaptation. I address some of these open questions in my PhD thesis.\r\nFirst, how do patterns of phenotypic sexual dimorphism vary within populations,\r\nas a response to the temporal and spatial changes in sex-specific selective forces? To\r\ntackle this question, I analyze the patterns of sex-specific phenotypic variation along\r\nthree life stages and across populations spanning the whole geographical range of Rumex\r\nhastatulus, a wind-pollinated angiosperm, in the first Chapter of the thesis.\r\nSecond, how do gene expression patterns lead to phenotypic dimorphism, and what\r\nare the molecular mechanisms underlying the observed transcriptomic variation? I\r\naddress this question by examining the sex- and tissue-specific expression variation in\r\nnewly-generated datasets of sex-specific expression in heads and gonads of Drosophila\r\nmelanogaster. I additionally used two complementary approaches for the study of the\r\ngenetic basis of sex di↵erences in gene expression in the second and third Chapters of\r\nthe thesis.\r\nThird, how does intersex correlation, thought to be one of the main aspects constraining the ability for the two sexes to decouple, interact with the evolution of sexual\r\ndimorphism? I develop models of sex-specific stabilizing selection, mutation and drift\r\nto formalize common intuition regarding the patterns of covariation between intersex\r\ncorrelation and sexual dimorphism in the fourth Chapter of the thesis.\r\nAlltogether, the work described in this PhD thesis provides useful insights into the\r\nlinks between genetic, transcriptomic and phenotypic layers of sex-specific variation,\r\nand contributes to our general understanding of the dynamics of sexual dimorphism\r\nevolution.","lang":"eng"}],"date_created":"2023-08-15T10:20:40Z","ec_funded":1,"year":"2023","_id":"14058","has_accepted_license":"1","project":[{"name":"International IST Doctoral Program","call_identifier":"H2020","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","grant_number":"665385"},{"name":"Sexual conflict: resolution, constraints and biomedical implications","_id":"9B9DFC9E-BA93-11EA-9121-9846C619BF3A","grant_number":"25817"}],"title":"The molecular basis of sexual dimorphism: Experimental and theoretical characterization of phenotypic, transcriptomic and genetic patterns of sex-specific adaptation","day":"15","publication_identifier":{"isbn":["978-3-99078-035-0"],"issn":["2663-337X"]},"oa":1,"author":[{"orcid":"0000-0001-8330-1754","full_name":"Puixeu Sala, Gemma","id":"33AB266C-F248-11E8-B48F-1D18A9856A87","first_name":"Gemma","last_name":"Puixeu Sala"}],"date_updated":"2023-12-13T12:15:36Z","citation":{"short":"G. Puixeu Sala, The Molecular Basis of Sexual Dimorphism: Experimental and Theoretical Characterization of Phenotypic, Transcriptomic and Genetic Patterns of Sex-Specific Adaptation, Institute of Science and Technology Austria, 2023.","mla":"Puixeu Sala, Gemma. <i>The Molecular Basis of Sexual Dimorphism: Experimental and Theoretical Characterization of Phenotypic, Transcriptomic and Genetic Patterns of Sex-Specific Adaptation</i>. Institute of Science and Technology Austria, 2023, doi:<a href=\"https://doi.org/10.15479/at:ista:14058\">10.15479/at:ista:14058</a>.","ama":"Puixeu Sala G. The molecular basis of sexual dimorphism: Experimental and theoretical characterization of phenotypic, transcriptomic and genetic patterns of sex-specific adaptation. 2023. doi:<a href=\"https://doi.org/10.15479/at:ista:14058\">10.15479/at:ista:14058</a>","apa":"Puixeu Sala, G. (2023). <i>The molecular basis of sexual dimorphism: Experimental and theoretical characterization of phenotypic, transcriptomic and genetic patterns of sex-specific adaptation</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/at:ista:14058\">https://doi.org/10.15479/at:ista:14058</a>","ieee":"G. Puixeu Sala, “The molecular basis of sexual dimorphism: Experimental and theoretical characterization of phenotypic, transcriptomic and genetic patterns of sex-specific adaptation,” Institute of Science and Technology Austria, 2023.","chicago":"Puixeu Sala, Gemma. “The Molecular Basis of Sexual Dimorphism: Experimental and Theoretical Characterization of Phenotypic, Transcriptomic and Genetic Patterns of Sex-Specific Adaptation.” Institute of Science and Technology Austria, 2023. <a href=\"https://doi.org/10.15479/at:ista:14058\">https://doi.org/10.15479/at:ista:14058</a>.","ista":"Puixeu Sala G. 2023. The molecular basis of sexual dimorphism: Experimental and theoretical characterization of phenotypic, transcriptomic and genetic patterns of sex-specific adaptation. Institute of Science and Technology Austria."},"supervisor":[{"id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","full_name":"Vicoso, Beatriz","orcid":"0000-0002-4579-8306","first_name":"Beatriz","last_name":"Vicoso"},{"orcid":"0000-0002-8548-5240","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","full_name":"Barton, Nicholas H","last_name":"Barton","first_name":"Nicholas H"}],"degree_awarded":"PhD","publisher":"Institute of Science and Technology Austria","department":[{"_id":"GradSch"},{"_id":"NiBa"},{"_id":"BeVi"}],"month":"08","page":"230","ddc":["576"],"alternative_title":["ISTA Thesis"],"doi":"10.15479/at:ista:14058","date_published":"2023-08-15T00:00:00Z","language":[{"iso":"eng"}],"status":"public","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"file_date_updated":"2023-08-18T10:47:55Z","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","type":"dissertation"},{"citation":{"short":"M. Chalupa, T.A. Henzinger, in:, 23nd International Conference on Runtime Verification, Springer Nature, 2023, pp. 168–190.","ista":"Chalupa M, Henzinger TA. 2023. Monitoring hyperproperties with prefix transducers. 23nd International Conference on Runtime Verification. RV: Conference on Runtime Verification, LNCS, vol. 14245, 168–190.","chicago":"Chalupa, Marek, and Thomas A Henzinger. “Monitoring Hyperproperties with Prefix Transducers.” In <i>23nd International Conference on Runtime Verification</i>, 14245:168–90. Springer Nature, 2023. <a href=\"https://doi.org/10.1007/978-3-031-44267-4_9\">https://doi.org/10.1007/978-3-031-44267-4_9</a>.","ieee":"M. Chalupa and T. A. Henzinger, “Monitoring hyperproperties with prefix transducers,” in <i>23nd International Conference on Runtime Verification</i>, Thessaloniki, Greek, 2023, vol. 14245, pp. 168–190.","ama":"Chalupa M, Henzinger TA. Monitoring hyperproperties with prefix transducers. In: <i>23nd International Conference on Runtime Verification</i>. Vol 14245. Springer Nature; 2023:168-190. doi:<a href=\"https://doi.org/10.1007/978-3-031-44267-4_9\">10.1007/978-3-031-44267-4_9</a>","apa":"Chalupa, M., &#38; Henzinger, T. A. (2023). Monitoring hyperproperties with prefix transducers. In <i>23nd International Conference on Runtime Verification</i> (Vol. 14245, pp. 168–190). Thessaloniki, Greek: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-031-44267-4_9\">https://doi.org/10.1007/978-3-031-44267-4_9</a>","mla":"Chalupa, Marek, and Thomas A. Henzinger. “Monitoring Hyperproperties with Prefix Transducers.” <i>23nd International Conference on Runtime Verification</i>, vol. 14245, Springer Nature, 2023, pp. 168–90, doi:<a href=\"https://doi.org/10.1007/978-3-031-44267-4_9\">10.1007/978-3-031-44267-4_9</a>."},"date_updated":"2024-02-28T12:33:08Z","author":[{"last_name":"Chalupa","first_name":"Marek","id":"87e34708-d6c6-11ec-9f5b-9391e7be2463","full_name":"Chalupa, Marek"},{"first_name":"Thomas A","last_name":"Henzinger","orcid":"0000-0002-2985-7724","id":"40876CD8-F248-11E8-B48F-1D18A9856A87","full_name":"Henzinger, Thomas A"}],"day":"01","oa":1,"publication":"23nd International Conference on Runtime Verification","publication_identifier":{"eisbn":["978-3-031-44267-4"],"isbn":["978-3-031-44266-7"]},"title":"Monitoring hyperproperties with prefix transducers","project":[{"name":"Vigilant Algorithmic Monitoring of Software","call_identifier":"H2020","grant_number":"101020093","_id":"62781420-2b32-11ec-9570-8d9b63373d4d"}],"has_accepted_license":"1","ec_funded":1,"date_created":"2023-08-16T20:46:08Z","_id":"14076","year":"2023","related_material":{"record":[{"status":"public","id":"15035","relation":"research_data"}]},"publication_status":"published","abstract":[{"text":"Hyperproperties are properties that relate multiple execution traces. Previous work on monitoring hyperproperties focused on synchronous hyperproperties, usually specified in HyperLTL. When monitoring synchronous hyperproperties, all traces are assumed to proceed at the same speed. We introduce (multi-trace) prefix transducers and show how to use them for monitoring synchronous as well as, for the first time, asynchronous hyperproperties. Prefix transducers map multiple input traces into one or more output traces by incrementally matching prefixes of the input traces against expressions similar to regular expressions. The prefixes of different traces which are consumed by a single matching step of the monitor may have different lengths. The deterministic and executable nature of prefix transducers makes them more suitable as an intermediate formalism for runtime verification than logical specifications, which tend to be highly non-deterministic, especially in the case of asynchronous hyperproperties. We report on a set of experiments about monitoring asynchronous version of observational determinism.","lang":"eng"}],"file":[{"date_updated":"2023-10-16T07:15:11Z","file_id":"14430","date_created":"2023-10-16T07:15:11Z","success":1,"relation":"main_file","file_name":"2023_LNCS_RV_Chalupa.pdf","access_level":"open_access","creator":"dernst","file_size":867256,"content_type":"application/pdf","checksum":"ee33bd6f1a26f4dae7a8192584869fd8"}],"quality_controlled":"1","article_processing_charge":"Yes (in subscription journal)","oa_version":"Published Version","type":"conference","volume":14245,"file_date_updated":"2023-10-16T07:15:11Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_published":"2023-10-01T00:00:00Z","doi":"10.1007/978-3-031-44267-4_9","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"status":"public","language":[{"iso":"eng"}],"intvolume":"     14245","ddc":["000"],"alternative_title":["LNCS"],"page":"168-190","conference":{"end_date":"2023-10-07","start_date":"2023-10-04","name":"RV: Conference on Runtime Verification","location":"Thessaloniki, Greek"},"acknowledgement":"This work was supported in part by the ERC-2020-AdG 101020093. The authors would like to thank Ana Oliveira da Costa for commenting on a draft of the paper.","month":"10","department":[{"_id":"ToHe"}],"publisher":"Springer Nature"},{"title":"Sex-specific estimation of cis and trans regulation of gene expression in heads and gonads of Drosophila melanogaster","external_id":{"isi":["001002997200001"]},"project":[{"name":"International IST Doctoral Program","call_identifier":"H2020","grant_number":"665385","_id":"2564DBCA-B435-11E9-9278-68D0E5697425"},{"name":"Sexual conflict: resolution, constraints and biomedical implications","_id":"9B9DFC9E-BA93-11EA-9121-9846C619BF3A","grant_number":"25817"}],"issue":"8","has_accepted_license":"1","date_updated":"2023-12-13T12:15:37Z","author":[{"first_name":"Gemma","last_name":"Puixeu Sala","id":"33AB266C-F248-11E8-B48F-1D18A9856A87","full_name":"Puixeu Sala, Gemma","orcid":"0000-0001-8330-1754"},{"last_name":"Macon","first_name":"Ariana","id":"2A0848E2-F248-11E8-B48F-1D18A9856A87","full_name":"Macon, Ariana"},{"orcid":"0000-0002-4579-8306","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","full_name":"Vicoso, Beatriz","last_name":"Vicoso","first_name":"Beatriz"}],"citation":{"chicago":"Puixeu Sala, Gemma, Ariana Macon, and Beatriz Vicoso. “Sex-Specific Estimation of Cis and Trans Regulation of Gene Expression in Heads and Gonads of Drosophila Melanogaster.” <i>G3: Genes, Genomes, Genetics</i>. Oxford University Press, 2023. <a href=\"https://doi.org/10.1093/g3journal/jkad121\">https://doi.org/10.1093/g3journal/jkad121</a>.","ista":"Puixeu Sala G, Macon A, Vicoso B. 2023. Sex-specific estimation of cis and trans regulation of gene expression in heads and gonads of Drosophila melanogaster. G3: Genes, Genomes, Genetics. 13(8).","mla":"Puixeu Sala, Gemma, et al. “Sex-Specific Estimation of Cis and Trans Regulation of Gene Expression in Heads and Gonads of Drosophila Melanogaster.” <i>G3: Genes, Genomes, Genetics</i>, vol. 13, no. 8, Oxford University Press, 2023, doi:<a href=\"https://doi.org/10.1093/g3journal/jkad121\">10.1093/g3journal/jkad121</a>.","ieee":"G. Puixeu Sala, A. Macon, and B. Vicoso, “Sex-specific estimation of cis and trans regulation of gene expression in heads and gonads of Drosophila melanogaster,” <i>G3: Genes, Genomes, Genetics</i>, vol. 13, no. 8. Oxford University Press, 2023.","apa":"Puixeu Sala, G., Macon, A., &#38; Vicoso, B. (2023). Sex-specific estimation of cis and trans regulation of gene expression in heads and gonads of Drosophila melanogaster. <i>G3: Genes, Genomes, Genetics</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/g3journal/jkad121\">https://doi.org/10.1093/g3journal/jkad121</a>","ama":"Puixeu Sala G, Macon A, Vicoso B. Sex-specific estimation of cis and trans regulation of gene expression in heads and gonads of Drosophila melanogaster. <i>G3: Genes, Genomes, Genetics</i>. 2023;13(8). doi:<a href=\"https://doi.org/10.1093/g3journal/jkad121\">10.1093/g3journal/jkad121</a>","short":"G. Puixeu Sala, A. Macon, B. Vicoso, G3: Genes, Genomes, Genetics 13 (2023)."},"oa":1,"publication_identifier":{"issn":["2160-1836"]},"publication":"G3: Genes, Genomes, Genetics","day":"01","abstract":[{"text":"The regulatory architecture of gene expression is known to differ substantially between sexes in Drosophila, but most studies performed\r\nso far used whole-body data and only single crosses, which may have limited their scope to detect patterns that are robust across tissues\r\nand biological replicates. Here, we use allele-specific gene expression of parental and reciprocal hybrid crosses between 6 Drosophila\r\nmelanogaster inbred lines to quantify cis- and trans-regulatory variation in heads and gonads of both sexes separately across 3 replicate\r\ncrosses. Our results suggest that female and male heads, as well as ovaries, have a similar regulatory architecture. On the other hand,\r\ntestes display more and substantially different cis-regulatory effects, suggesting that sex differences in the regulatory architecture that\r\nhave been previously observed may largely derive from testis-specific effects. We also examine the difference in cis-regulatory variation\r\nof genes across different levels of sex bias in gonads and heads. Consistent with the idea that intersex correlations constrain expression\r\nand can lead to sexual antagonism, we find more cis variation in unbiased and moderately biased genes in heads. In ovaries, reduced cis\r\nvariation is observed for male-biased genes, suggesting that cis variants acting on these genes in males do not lead to changes in ovary\r\nexpression. Finally, we examine the dominance patterns of gene expression and find that sex- and tissue-specific patterns of inheritance\r\nas well as trans-regulatory variation are highly variable across biological crosses, although these were performed in highly controlled\r\nexperimental conditions. This highlights the importance of using various genetic backgrounds to infer generalizable patterns.","lang":"eng"}],"file":[{"creator":"dernst","access_level":"open_access","checksum":"c62e29fc7c5efbf8356f4c60cab4a2d1","file_size":845642,"content_type":"application/pdf","date_updated":"2023-11-07T09:00:19Z","file_name":"2023_G3_Puixeu.pdf","success":1,"relation":"main_file","date_created":"2023-11-07T09:00:19Z","file_id":"14498"}],"publication_status":"published","related_material":{"record":[{"id":"12933","status":"public","relation":"research_data"},{"relation":"dissertation_contains","id":"14058","status":"public"}]},"article_type":"original","keyword":["Genetics (clinical)","Genetics","Molecular Biology"],"article_processing_charge":"Yes","oa_version":"Published Version","quality_controlled":"1","acknowledged_ssus":[{"_id":"ScienComp"}],"_id":"14077","year":"2023","date_created":"2023-08-18T06:52:14Z","ec_funded":1,"status":"public","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"language":[{"iso":"eng"}],"date_published":"2023-08-01T00:00:00Z","doi":"10.1093/g3journal/jkad121","intvolume":"        13","ddc":["570"],"volume":13,"type":"journal_article","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","file_date_updated":"2023-11-07T09:00:19Z","month":"08","department":[{"_id":"BeVi"},{"_id":"NiBa"},{"_id":"GradSch"}],"publisher":"Oxford University Press","isi":1,"scopus_import":"1","acknowledgement":"We thank members of the Vicoso Group for comments on the manuscript, the Scientific Computing Unit at ISTA for technical support, and 2 anonymous reviewers for useful feedback. GP is the recipient of a DOC Fellowship of the Austrian Academy of Sciences at the Institute of Science and Technology Austria (DOC 25817) and received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie Grant (agreement no. 665385)."},{"_id":"14080","year":"2023","date_created":"2023-08-20T22:01:12Z","pmid":1,"article_processing_charge":"Yes (in subscription journal)","oa_version":"Published Version","quality_controlled":"1","abstract":[{"text":"Extracellular signal-regulated kinase (ERK) has been recognized as a critical regulator in various physiological and pathological processes. Extensive research has elucidated the signaling mechanisms governing ERK activation via biochemical regulations with upstream molecules, particularly receptor tyrosine kinases (RTKs). However, recent advances have highlighted the role of mechanical forces in activating the RTK–ERK signaling pathways, thereby opening new avenues of research into mechanochemical interplay in multicellular tissues. Here, we review the force-induced ERK activation in cells and propose possible mechanosensing mechanisms underlying the mechanoresponsive ERK activation. We conclude that mechanical forces are not merely passive factors shaping cells and tissues but also active regulators of cellular signaling pathways controlling collective cell behaviors.","lang":"eng"}],"file":[{"relation":"main_file","date_created":"2024-01-30T12:52:12Z","success":1,"file_id":"14909","file_name":"2023_CurrentOpinionCellBio_Hirashima.pdf","date_updated":"2024-01-30T12:52:12Z","file_size":1173762,"content_type":"application/pdf","checksum":"25923f8ae71344e8974530dd23c71bdc","creator":"dernst","access_level":"open_access"}],"article_type":"review","publication_status":"published","oa":1,"publication":"Current Opinion in Cell Biology","publication_identifier":{"issn":["0955-0674"],"eissn":["1879-0410"]},"day":"01","citation":{"ama":"Hirashima T, Hino N, Aoki K, Matsuda M. Stretching the limits of extracellular signal-related kinase (ERK) signaling — Cell mechanosensing to ERK activation. <i>Current Opinion in Cell Biology</i>. 2023;84(10). doi:<a href=\"https://doi.org/10.1016/j.ceb.2023.102217\">10.1016/j.ceb.2023.102217</a>","ieee":"T. Hirashima, N. Hino, K. Aoki, and M. Matsuda, “Stretching the limits of extracellular signal-related kinase (ERK) signaling — Cell mechanosensing to ERK activation,” <i>Current Opinion in Cell Biology</i>, vol. 84, no. 10. Elsevier, 2023.","apa":"Hirashima, T., Hino, N., Aoki, K., &#38; Matsuda, M. (2023). Stretching the limits of extracellular signal-related kinase (ERK) signaling — Cell mechanosensing to ERK activation. <i>Current Opinion in Cell Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.ceb.2023.102217\">https://doi.org/10.1016/j.ceb.2023.102217</a>","mla":"Hirashima, Tsuyoshi, et al. “Stretching the Limits of Extracellular Signal-Related Kinase (ERK) Signaling — Cell Mechanosensing to ERK Activation.” <i>Current Opinion in Cell Biology</i>, vol. 84, no. 10, 102217, Elsevier, 2023, doi:<a href=\"https://doi.org/10.1016/j.ceb.2023.102217\">10.1016/j.ceb.2023.102217</a>.","ista":"Hirashima T, Hino N, Aoki K, Matsuda M. 2023. Stretching the limits of extracellular signal-related kinase (ERK) signaling — Cell mechanosensing to ERK activation. Current Opinion in Cell Biology. 84(10), 102217.","chicago":"Hirashima, Tsuyoshi, Naoya Hino, Kazuhiro Aoki, and Michiyuki Matsuda. “Stretching the Limits of Extracellular Signal-Related Kinase (ERK) Signaling — Cell Mechanosensing to ERK Activation.” <i>Current Opinion in Cell Biology</i>. Elsevier, 2023. <a href=\"https://doi.org/10.1016/j.ceb.2023.102217\">https://doi.org/10.1016/j.ceb.2023.102217</a>.","short":"T. Hirashima, N. Hino, K. Aoki, M. Matsuda, Current Opinion in Cell Biology 84 (2023)."},"author":[{"last_name":"Hirashima","first_name":"Tsuyoshi","full_name":"Hirashima, Tsuyoshi"},{"id":"5299a9ce-7679-11eb-a7bc-d1e62b936307","full_name":"Hino, Naoya","last_name":"Hino","first_name":"Naoya"},{"first_name":"Kazuhiro","last_name":"Aoki","full_name":"Aoki, Kazuhiro"},{"first_name":"Michiyuki","last_name":"Matsuda","full_name":"Matsuda, Michiyuki"}],"date_updated":"2024-01-30T12:52:42Z","article_number":"102217","issue":"10","has_accepted_license":"1","external_id":{"isi":["001054692200001"],"pmid":["37574635"]},"title":"Stretching the limits of extracellular signal-related kinase (ERK) signaling — Cell mechanosensing to ERK activation","scopus_import":"1","acknowledgement":"TH was supported by JSPS KAKENHI Grant (no. 21H05290) and the Ministry of Education under the Research Centres of Excellence programme through the Mechanobiology Institute at National University of Singapore and by Department of Physiology at National University of Singapore. NH was supported by JSPS KAKENHI Grant (no. 20K22653). KA was supported by JSPS KAKENHI Grants (no. 19H05798 and no. 22H02625). MM was supported by JSPS KAKENHI Grants (no. 19H00993 and no. 20H05898) and JST Moonshot R&D Grant JPMJPS2022. We appreciate Virgile Viasnoff and the lab members for their valuable comments on the manuscript. We apologize to authors whose work could not be highlighted due to space limitations.","isi":1,"month":"10","department":[{"_id":"CaHe"}],"publisher":"Elsevier","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","file_date_updated":"2024-01-30T12:52:12Z","volume":84,"type":"journal_article","ddc":["570"],"intvolume":"        84","status":"public","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"language":[{"iso":"eng"}],"date_published":"2023-10-01T00:00:00Z","doi":"10.1016/j.ceb.2023.102217"},{"type":"journal_article","volume":136,"file_date_updated":"2023-08-21T07:37:54Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","doi":"10.1242/jcs.260668","date_published":"2023-08-01T00:00:00Z","language":[{"iso":"eng"}],"status":"public","intvolume":"       136","ddc":["570"],"acknowledgement":"The authors thank their respective lab members for feedback and helpful discussions. We thank the bioimaging and zebrafish facilities of IST Austria for their support.\r\nThis work was supported by the National Institutes of Health [R01GM112794 to A.L.M.], by Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science [21K06156 to T.H.], by the Grant Program for Biomedical Engineering Research from the Nakatani Foundation for Advancement of Measuring Technologies in Biomedical Engineering [to T.H.] and by funding from the European Research Council [advanced grant 742573 to C.-P.H.]. ","scopus_import":"1","publisher":"The Company of Biologists","department":[{"_id":"CaHe"},{"_id":"EvBe"}],"month":"08","isi":1,"author":[{"full_name":"Higashi, Tomohito","first_name":"Tomohito","last_name":"Higashi"},{"full_name":"Stephenson, Rachel E.","first_name":"Rachel E.","last_name":"Stephenson"},{"last_name":"Schwayer","first_name":"Cornelia","id":"3436488C-F248-11E8-B48F-1D18A9856A87","full_name":"Schwayer, Cornelia","orcid":"0000-0001-5130-2226"},{"last_name":"Huljev","first_name":"Karla","full_name":"Huljev, Karla","id":"44C6F6A6-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Higashi, Atsuko Y.","first_name":"Atsuko Y.","last_name":"Higashi"},{"orcid":"0000-0002-0912-4566","id":"39427864-F248-11E8-B48F-1D18A9856A87","full_name":"Heisenberg, Carl-Philipp J","last_name":"Heisenberg","first_name":"Carl-Philipp J"},{"full_name":"Chiba, Hideki","first_name":"Hideki","last_name":"Chiba"},{"full_name":"Miller, Ann L.","first_name":"Ann L.","last_name":"Miller"}],"date_updated":"2023-12-13T12:11:18Z","citation":{"mla":"Higashi, Tomohito, et al. “ZnUMBA - a Live Imaging Method to Detect Local Barrier Breaches.” <i>Journal of Cell Science</i>, vol. 136, no. 15, jcs260668, The Company of Biologists, 2023, doi:<a href=\"https://doi.org/10.1242/jcs.260668\">10.1242/jcs.260668</a>.","apa":"Higashi, T., Stephenson, R. E., Schwayer, C., Huljev, K., Higashi, A. Y., Heisenberg, C.-P. J., … Miller, A. L. (2023). ZnUMBA - a live imaging method to detect local barrier breaches. <i>Journal of Cell Science</i>. The Company of Biologists. <a href=\"https://doi.org/10.1242/jcs.260668\">https://doi.org/10.1242/jcs.260668</a>","ama":"Higashi T, Stephenson RE, Schwayer C, et al. ZnUMBA - a live imaging method to detect local barrier breaches. <i>Journal of Cell Science</i>. 2023;136(15). doi:<a href=\"https://doi.org/10.1242/jcs.260668\">10.1242/jcs.260668</a>","ieee":"T. Higashi <i>et al.</i>, “ZnUMBA - a live imaging method to detect local barrier breaches,” <i>Journal of Cell Science</i>, vol. 136, no. 15. The Company of Biologists, 2023.","chicago":"Higashi, Tomohito, Rachel E. Stephenson, Cornelia Schwayer, Karla Huljev, Atsuko Y. Higashi, Carl-Philipp J Heisenberg, Hideki Chiba, and Ann L. Miller. “ZnUMBA - a Live Imaging Method to Detect Local Barrier Breaches.” <i>Journal of Cell Science</i>. The Company of Biologists, 2023. <a href=\"https://doi.org/10.1242/jcs.260668\">https://doi.org/10.1242/jcs.260668</a>.","ista":"Higashi T, Stephenson RE, Schwayer C, Huljev K, Higashi AY, Heisenberg C-PJ, Chiba H, Miller AL. 2023. ZnUMBA - a live imaging method to detect local barrier breaches. Journal of Cell Science. 136(15), jcs260668.","short":"T. Higashi, R.E. Stephenson, C. Schwayer, K. Huljev, A.Y. Higashi, C.-P.J. Heisenberg, H. Chiba, A.L. Miller, Journal of Cell Science 136 (2023)."},"day":"01","publication":"Journal of Cell Science","publication_identifier":{"eissn":["1477-9137"],"issn":["0021-9533"]},"project":[{"name":"Interaction and feedback between cell mechanics and fate specification in vertebrate gastrulation","grant_number":"742573","_id":"260F1432-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"}],"external_id":{"isi":["001070149000001"]},"title":"ZnUMBA - a live imaging method to detect local barrier breaches","has_accepted_license":"1","article_number":"jcs260668","issue":"15","acknowledged_ssus":[{"_id":"PreCl"},{"_id":"Bio"}],"ec_funded":1,"date_created":"2023-08-20T22:01:13Z","year":"2023","_id":"14082","publication_status":"published","article_type":"original","file":[{"file_size":18665315,"content_type":"application/pdf","checksum":"a399389b7e3d072f1788b63e612a10b3","creator":"dernst","access_level":"closed","relation":"main_file","date_created":"2023-08-21T07:37:54Z","file_id":"14092","embargo_to":"open_access","file_name":"2023_JourCellScience_Higashi.pdf","embargo":"2024-08-10","date_updated":"2023-08-21T07:37:54Z"}],"abstract":[{"lang":"eng","text":"Epithelial barrier function is commonly analyzed using transepithelial electrical resistance, which measures ion flux across a monolayer, or by adding traceable macromolecules and monitoring their passage across the monolayer. Although these methods measure changes in global barrier function, they lack the sensitivity needed to detect local or transient barrier breaches, and they do not reveal the location of barrier leaks. Therefore, we previously developed a method that we named the zinc-based ultrasensitive microscopic barrier assay (ZnUMBA), which overcomes these limitations, allowing for detection of local tight junction leaks with high spatiotemporal resolution. Here, we present expanded applications for ZnUMBA. ZnUMBA can be used in Xenopus embryos to measure the dynamics of barrier restoration and actin accumulation following laser injury. ZnUMBA can also be effectively utilized in developing zebrafish embryos as well as cultured monolayers of Madin–Darby canine kidney (MDCK) II epithelial cells. ZnUMBA is a powerful and flexible method that, with minimal optimization, can be applied to multiple systems to measure dynamic changes in barrier function with spatiotemporal precision."}],"quality_controlled":"1","oa_version":"None","article_processing_charge":"No"},{"day":"01","oa":1,"publication_identifier":{"isbn":["9783959772785"],"issn":["1868-8969"]},"publication":"50th International Colloquium on Automata, Languages, and Programming","author":[{"last_name":"Resch","first_name":"Nicolas","full_name":"Resch, Nicolas"},{"full_name":"Yuan, Chen","last_name":"Yuan","first_name":"Chen"},{"last_name":"Zhang","first_name":"Yihan","orcid":"0000-0002-6465-6258","full_name":"Zhang, Yihan","id":"2ce5da42-b2ea-11eb-bba5-9f264e9d002c"}],"date_updated":"2023-08-21T07:26:01Z","citation":{"mla":"Resch, Nicolas, et al. “Zero-Rate Thresholds and New Capacity Bounds for List-Decoding and List-Recovery.” <i>50th International Colloquium on Automata, Languages, and Programming</i>, vol. 261, 99, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2023, doi:<a href=\"https://doi.org/10.4230/LIPIcs.ICALP.2023.99\">10.4230/LIPIcs.ICALP.2023.99</a>.","apa":"Resch, N., Yuan, C., &#38; Zhang, Y. (2023). Zero-rate thresholds and new capacity bounds for list-decoding and list-recovery. In <i>50th International Colloquium on Automata, Languages, and Programming</i> (Vol. 261). Paderborn, Germany: Schloss Dagstuhl - Leibniz-Zentrum für Informatik. <a href=\"https://doi.org/10.4230/LIPIcs.ICALP.2023.99\">https://doi.org/10.4230/LIPIcs.ICALP.2023.99</a>","ama":"Resch N, Yuan C, Zhang Y. Zero-rate thresholds and new capacity bounds for list-decoding and list-recovery. In: <i>50th International Colloquium on Automata, Languages, and Programming</i>. Vol 261. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2023. doi:<a href=\"https://doi.org/10.4230/LIPIcs.ICALP.2023.99\">10.4230/LIPIcs.ICALP.2023.99</a>","ieee":"N. Resch, C. Yuan, and Y. Zhang, “Zero-rate thresholds and new capacity bounds for list-decoding and list-recovery,” in <i>50th International Colloquium on Automata, Languages, and Programming</i>, Paderborn, Germany, 2023, vol. 261.","chicago":"Resch, Nicolas, Chen Yuan, and Yihan Zhang. “Zero-Rate Thresholds and New Capacity Bounds for List-Decoding and List-Recovery.” In <i>50th International Colloquium on Automata, Languages, and Programming</i>, Vol. 261. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2023. <a href=\"https://doi.org/10.4230/LIPIcs.ICALP.2023.99\">https://doi.org/10.4230/LIPIcs.ICALP.2023.99</a>.","ista":"Resch N, Yuan C, Zhang Y. 2023. Zero-rate thresholds and new capacity bounds for list-decoding and list-recovery. 50th International Colloquium on Automata, Languages, and Programming. ICALP: International Colloquium on Automata, Languages, and Programming, LIPIcs, vol. 261, 99.","short":"N. Resch, C. Yuan, Y. Zhang, in:, 50th International Colloquium on Automata, Languages, and Programming, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2023."},"has_accepted_license":"1","article_number":"99","title":"Zero-rate thresholds and new capacity bounds for list-decoding and list-recovery","external_id":{"arxiv":["2210.07754"]},"date_created":"2023-08-20T22:01:13Z","_id":"14083","year":"2023","quality_controlled":"1","article_processing_charge":"Yes","oa_version":"Published Version","publication_status":"published","abstract":[{"lang":"eng","text":"In this work we consider the list-decodability and list-recoverability of arbitrary q-ary codes, for all integer values of q ≥ 2. A code is called (p,L)_q-list-decodable if every radius pn Hamming ball contains less than L codewords; (p,𝓁,L)_q-list-recoverability is a generalization where we place radius pn Hamming balls on every point of a combinatorial rectangle with side length 𝓁 and again stipulate that there be less than L codewords.\r\nOur main contribution is to precisely calculate the maximum value of p for which there exist infinite families of positive rate (p,𝓁,L)_q-list-recoverable codes, the quantity we call the zero-rate threshold. Denoting this value by p_*, we in fact show that codes correcting a p_*+ε fraction of errors must have size O_ε(1), i.e., independent of n. Such a result is typically referred to as a \"Plotkin bound.\" To complement this, a standard random code with expurgation construction shows that there exist positive rate codes correcting a p_*-ε fraction of errors. We also follow a classical proof template (typically attributed to Elias and Bassalygo) to derive from the zero-rate threshold other tradeoffs between rate and decoding radius for list-decoding and list-recovery.\r\nTechnically, proving the Plotkin bound boils down to demonstrating the Schur convexity of a certain function defined on the q-simplex as well as the convexity of a univariate function derived from it. We remark that an earlier argument claimed similar results for q-ary list-decoding; however, we point out that this earlier proof is flawed."}],"file":[{"checksum":"a449143fec3fbebb092cb8ef3b53c226","content_type":"application/pdf","file_size":1141497,"creator":"dernst","access_level":"open_access","file_name":"2023_LIPIcsICALP_Resch.pdf","relation":"main_file","success":1,"date_created":"2023-08-21T07:23:18Z","file_id":"14091","date_updated":"2023-08-21T07:23:18Z"}],"file_date_updated":"2023-08-21T07:23:18Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"conference","volume":261,"alternative_title":["LIPIcs"],"ddc":["000"],"intvolume":"       261","date_published":"2023-07-01T00:00:00Z","doi":"10.4230/LIPIcs.ICALP.2023.99","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"status":"public","language":[{"iso":"eng"}],"acknowledgement":"Nicolas Resch: Research supported in part by ERC H2020 grant No.74079 (ALGSTRONGCRYPTO). Chen Yuan: Research supported in part by the National Key Research and Development Projects under Grant 2022YFA1004900 and Grant 2021YFE0109900, the National Natural Science Foundation of China under Grant 12101403 and Grant 12031011.\r\nAcknowledgements YZ is grateful to Shashank Vatedka, Diyuan Wu and Fengxing Zhu for inspiring discussions.","scopus_import":"1","arxiv":1,"conference":{"start_date":"2023-07-10","location":"Paderborn, Germany","name":"ICALP: International Colloquium on Automata, Languages, and Programming","end_date":"2023-07-14"},"month":"07","department":[{"_id":"MaMo"}],"publisher":"Schloss Dagstuhl - Leibniz-Zentrum für Informatik"},{"acknowledgement":"We thank Heng Guo for helpful explanations of algorithms for sampling connected subgraphs and matchings, Maksym Serbyn for bringing to our attention the Wang-Landau algorithm and its use in physics.","scopus_import":"1","arxiv":1,"conference":{"end_date":"2023-07-14","name":"ICALP: International Colloquium on Automata, Languages, and Programming","start_date":"2023-07-10","location":"Paderborn, Germany"},"month":"07","publisher":"Schloss Dagstuhl - Leibniz-Zentrum für Informatik","department":[{"_id":"VlKo"}],"file_date_updated":"2023-08-21T06:45:16Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"conference","volume":261,"ddc":["000","510"],"alternative_title":["LIPIcs"],"intvolume":"       261","date_published":"2023-07-01T00:00:00Z","doi":"10.4230/LIPIcs.ICALP.2023.72","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"status":"public","language":[{"iso":"eng"}],"date_created":"2023-08-20T22:01:14Z","_id":"14084","year":"2023","quality_controlled":"1","article_processing_charge":"Yes","oa_version":"Published Version","publication_status":"published","abstract":[{"text":"A central problem in computational statistics is to convert a procedure for sampling combinatorial objects into a procedure for counting those objects, and vice versa. We will consider sampling problems which come from Gibbs distributions, which are families of probability distributions over a discrete space Ω with probability mass function of the form μ^Ω_β(ω) ∝ e^{β H(ω)} for β in an interval [β_min, β_max] and H(ω) ∈ {0} ∪ [1, n].\r\nThe partition function is the normalization factor Z(β) = ∑_{ω ∈ Ω} e^{β H(ω)}, and the log partition ratio is defined as q = (log Z(β_max))/Z(β_min)\r\nWe develop a number of algorithms to estimate the counts c_x using roughly Õ(q/ε²) samples for general Gibbs distributions and Õ(n²/ε²) samples for integer-valued distributions (ignoring some second-order terms and parameters), We show this is optimal up to logarithmic factors. We illustrate with improved algorithms for counting connected subgraphs and perfect matchings in a graph.","lang":"eng"}],"file":[{"date_updated":"2023-08-21T06:45:16Z","file_name":"2023_LIPIcsICALP_Harris.pdf","file_id":"14088","success":1,"date_created":"2023-08-21T06:45:16Z","relation":"main_file","access_level":"open_access","creator":"dernst","checksum":"6dee0684245bb1c524b9c955db1e933d","file_size":917791,"content_type":"application/pdf"}],"day":"01","oa":1,"publication":"50th International Colloquium on Automata, Languages, and Programming","publication_identifier":{"isbn":["9783959772785"],"issn":["1868-8969"]},"author":[{"last_name":"Harris","first_name":"David G.","full_name":"Harris, David G."},{"last_name":"Kolmogorov","first_name":"Vladimir","id":"3D50B0BA-F248-11E8-B48F-1D18A9856A87","full_name":"Kolmogorov, Vladimir"}],"date_updated":"2023-08-21T06:49:11Z","citation":{"short":"D.G. Harris, V. Kolmogorov, in:, 50th International Colloquium on Automata, Languages, and Programming, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2023.","ista":"Harris DG, Kolmogorov V. 2023. Parameter estimation for Gibbs distributions. 50th International Colloquium on Automata, Languages, and Programming. ICALP: International Colloquium on Automata, Languages, and Programming, LIPIcs, vol. 261, 72.","chicago":"Harris, David G., and Vladimir Kolmogorov. “Parameter Estimation for Gibbs Distributions.” In <i>50th International Colloquium on Automata, Languages, and Programming</i>, Vol. 261. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2023. <a href=\"https://doi.org/10.4230/LIPIcs.ICALP.2023.72\">https://doi.org/10.4230/LIPIcs.ICALP.2023.72</a>.","ama":"Harris DG, Kolmogorov V. Parameter estimation for Gibbs distributions. In: <i>50th International Colloquium on Automata, Languages, and Programming</i>. Vol 261. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2023. doi:<a href=\"https://doi.org/10.4230/LIPIcs.ICALP.2023.72\">10.4230/LIPIcs.ICALP.2023.72</a>","ieee":"D. G. Harris and V. Kolmogorov, “Parameter estimation for Gibbs distributions,” in <i>50th International Colloquium on Automata, Languages, and Programming</i>, Paderborn, Germany, 2023, vol. 261.","apa":"Harris, D. G., &#38; Kolmogorov, V. (2023). Parameter estimation for Gibbs distributions. In <i>50th International Colloquium on Automata, Languages, and Programming</i> (Vol. 261). Paderborn, Germany: Schloss Dagstuhl - Leibniz-Zentrum für Informatik. <a href=\"https://doi.org/10.4230/LIPIcs.ICALP.2023.72\">https://doi.org/10.4230/LIPIcs.ICALP.2023.72</a>","mla":"Harris, David G., and Vladimir Kolmogorov. “Parameter Estimation for Gibbs Distributions.” <i>50th International Colloquium on Automata, Languages, and Programming</i>, vol. 261, 72, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2023, doi:<a href=\"https://doi.org/10.4230/LIPIcs.ICALP.2023.72\">10.4230/LIPIcs.ICALP.2023.72</a>."},"has_accepted_license":"1","article_number":"72","external_id":{"arxiv":["2007.10824"]},"title":"Parameter estimation for Gibbs distributions"},{"publication_status":"published","file":[{"content_type":"application/pdf","file_size":875910,"checksum":"074177e815a1656de5d4071c7a3dffa6","creator":"dernst","access_level":"open_access","relation":"main_file","success":1,"date_created":"2023-08-21T06:59:05Z","file_id":"14089","file_name":"2023_LIPIcsICALP_Goranci.pdf","date_updated":"2023-08-21T06:59:05Z"}],"abstract":[{"text":"We show an (1+ϵ)-approximation algorithm for maintaining maximum s-t flow under m edge insertions in m1/2+o(1)ϵ−1/2 amortized update time for directed, unweighted graphs. This constitutes the first sublinear dynamic maximum flow algorithm in general sparse graphs with arbitrarily good approximation guarantee.","lang":"eng"}],"quality_controlled":"1","oa_version":"Published Version","article_processing_charge":"Yes","ec_funded":1,"date_created":"2023-08-20T22:01:14Z","year":"2023","_id":"14085","project":[{"name":"The design and evaluation of modern fully dynamic data structures","grant_number":"101019564","call_identifier":"H2020","_id":"bd9ca328-d553-11ed-ba76-dc4f890cfe62"},{"name":"Static and Dynamic Hierarchical Graph Decompositions","_id":"bda196b2-d553-11ed-ba76-8e8ee6c21103","grant_number":"I05982"},{"grant_number":"P33775 ","_id":"bd9e3a2e-d553-11ed-ba76-8aa684ce17fe","name":"Fast Algorithms for a Reactive Network Layer"}],"title":"Efficient data structures for incremental exact and approximate maximum flow","external_id":{"unknown":["2211.09606"]},"has_accepted_license":"1","article_number":"69","author":[{"first_name":"Gramoz","last_name":"Goranci","full_name":"Goranci, Gramoz"},{"orcid":"0000-0002-5008-6530","full_name":"Henzinger, Monika H","id":"540c9bbd-f2de-11ec-812d-d04a5be85630","last_name":"Henzinger","first_name":"Monika H"}],"date_updated":"2023-08-21T07:00:49Z","citation":{"short":"G. Goranci, M.H. Henzinger, in:, 50th International Colloquium on Automata, Languages, and Programming, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2023.","ista":"Goranci G, Henzinger MH. 2023. Efficient data structures for incremental exact and approximate maximum flow. 50th International Colloquium on Automata, Languages, and Programming. ICALP: International Colloquium on Automata, Languages, and Programming, LIPIcs, vol. 261, 69.","chicago":"Goranci, Gramoz, and Monika H Henzinger. “Efficient Data Structures for Incremental Exact and Approximate Maximum Flow.” In <i>50th International Colloquium on Automata, Languages, and Programming</i>, Vol. 261. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2023. <a href=\"https://doi.org/10.4230/LIPIcs.ICALP.2023.69\">https://doi.org/10.4230/LIPIcs.ICALP.2023.69</a>.","ieee":"G. Goranci and M. H. Henzinger, “Efficient data structures for incremental exact and approximate maximum flow,” in <i>50th International Colloquium on Automata, Languages, and Programming</i>, Paderborn, Germany, 2023, vol. 261.","ama":"Goranci G, Henzinger MH. Efficient data structures for incremental exact and approximate maximum flow. In: <i>50th International Colloquium on Automata, Languages, and Programming</i>. Vol 261. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2023. doi:<a href=\"https://doi.org/10.4230/LIPIcs.ICALP.2023.69\">10.4230/LIPIcs.ICALP.2023.69</a>","apa":"Goranci, G., &#38; Henzinger, M. H. (2023). Efficient data structures for incremental exact and approximate maximum flow. In <i>50th International Colloquium on Automata, Languages, and Programming</i> (Vol. 261). Paderborn, Germany: Schloss Dagstuhl - Leibniz-Zentrum für Informatik. <a href=\"https://doi.org/10.4230/LIPIcs.ICALP.2023.69\">https://doi.org/10.4230/LIPIcs.ICALP.2023.69</a>","mla":"Goranci, Gramoz, and Monika H. Henzinger. “Efficient Data Structures for Incremental Exact and Approximate Maximum Flow.” <i>50th International Colloquium on Automata, Languages, and Programming</i>, vol. 261, 69, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2023, doi:<a href=\"https://doi.org/10.4230/LIPIcs.ICALP.2023.69\">10.4230/LIPIcs.ICALP.2023.69</a>."},"day":"01","publication":"50th International Colloquium on Automata, Languages, and Programming","publication_identifier":{"isbn":["9783959772785"],"issn":["1868-8969"]},"oa":1,"publisher":"Schloss Dagstuhl - Leibniz-Zentrum für Informatik","department":[{"_id":"MoHe"}],"month":"07","conference":{"end_date":"2023-07-14","name":"ICALP: International Colloquium on Automata, Languages, and Programming","start_date":"2023-07-10","location":"Paderborn, Germany"},"acknowledgement":"This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant agreement No.\r\n101019564 “The Design of Modern Fully Dynamic Data Structures (MoDynStruct)” and from the\r\nAustrian Science Fund (FWF) project “Static and Dynamic Hierarchical Graph Decompositions”,\r\nI 5982-N, and project “Fast Algorithms for a Reactive Network Layer (ReactNet)”, P 33775-N, with additional funding from the netidee SCIENCE Stiftung, 2020–2024.\r\nThis work was done in part while Gramoz Goranci was at Institute for Theoretical Studies, ETH Zurich, Switzerland. There, he was supported by Dr. Max Rössler, the Walter Haefner Foundation and the ETH Zürich Foundation. We also thank Richard Peng, Thatchaphol Saranurak, Sebastian Forster and Sushant Sachdeva for helpful discussions, and the anonymous reviewers for their insightful comments.","scopus_import":"1","doi":"10.4230/LIPIcs.ICALP.2023.69","date_published":"2023-07-01T00:00:00Z","language":[{"iso":"eng"}],"status":"public","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"alternative_title":["LIPIcs"],"ddc":["000"],"intvolume":"       261","type":"conference","volume":261,"file_date_updated":"2023-08-21T06:59:05Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"},{"month":"07","publisher":"Schloss Dagstuhl - Leibniz-Zentrum für Informatik","department":[{"_id":"MoHe"}],"conference":{"end_date":"2023-07-14","name":"ICALP: International Colloquium on Automata, Languages, and Programming","location":"Paderborn, Germany","start_date":"2023-07-10"},"arxiv":1,"scopus_import":"1","acknowledgement":" Monika Henzinger: This project has received funding from the European Research Council\r\n(ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant\r\nagreement No. 101019564 “The Design of Modern Fully Dynamic Data Structures (MoDynStruct)” and from the Austrian Science Fund (FWF) project “Static and Dynamic Hierarchical Graph Decompositions”, I 5982-N, and project “Fast Algorithms for a Reactive Network Layer (ReactNet)”, P 33775-N, with additional funding from the netidee SCIENCE Stiftung, 2020–2024. Jan Vondrák: Supported by NSF Award 2127781.","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"status":"public","language":[{"iso":"eng"}],"date_published":"2023-07-01T00:00:00Z","doi":"10.4230/LIPIcs.ICALP.2023.74","intvolume":"       261","alternative_title":["LIPIcs"],"ddc":["000"],"volume":261,"type":"conference","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","file_date_updated":"2023-08-21T07:04:36Z","abstract":[{"lang":"eng","text":"The maximization of submodular functions have found widespread application in areas such as machine learning, combinatorial optimization, and economics, where practitioners often wish to enforce various constraints; the matroid constraint has been investigated extensively due to its algorithmic properties and expressive power. Though tight approximation algorithms for general matroid constraints exist in theory, the running times of such algorithms typically scale quadratically, and are not practical for truly large scale settings. Recent progress has focused on fast algorithms for important classes of matroids given in explicit form. Currently, nearly-linear time algorithms only exist for graphic and partition matroids [Alina Ene and Huy L. Nguyen, 2019]. In this work, we develop algorithms for monotone submodular maximization constrained by graphic, transversal matroids, or laminar matroids in time near-linear in the size of their representation. Our algorithms achieve an optimal approximation of 1-1/e-ε and both generalize and accelerate the results of Ene and Nguyen [Alina Ene and Huy L. Nguyen, 2019]. In fact, the running time of our algorithm cannot be improved within the fast continuous greedy framework of Badanidiyuru and Vondrák [Ashwinkumar Badanidiyuru and Jan Vondrák, 2014].\r\nTo achieve near-linear running time, we make use of dynamic data structures that maintain bases with approximate maximum cardinality and weight under certain element updates. These data structures need to support a weight decrease operation and a novel Freeze operation that allows the algorithm to freeze elements (i.e. force to be contained) in its basis regardless of future data structure operations. For the laminar matroid, we present a new dynamic data structure using the top tree interface of Alstrup, Holm, de Lichtenberg, and Thorup [Stephen Alstrup et al., 2005] that maintains the maximum weight basis under insertions and deletions of elements in O(log n) time. This data structure needs to support certain subtree query and path update operations that are performed every insertion and deletion that are non-trivial to handle in conjunction. For the transversal matroid the Freeze operation corresponds to requiring the data structure to keep a certain set S of vertices matched, a property that we call S-stability. While there is a large body of work on dynamic matching algorithms, none are S-stable and maintain an approximate maximum weight matching under vertex updates. We give the first such algorithm for bipartite graphs with total running time linear (up to log factors) in the number of edges."}],"file":[{"date_updated":"2023-08-21T07:04:36Z","file_id":"14090","relation":"main_file","success":1,"date_created":"2023-08-21T07:04:36Z","file_name":"2023_LIPIcsICALP_HenzingerM.pdf","access_level":"open_access","creator":"dernst","content_type":"application/pdf","file_size":930943,"checksum":"a5eef225014e003efbfbe4830fdd23cb"}],"publication_status":"published","article_processing_charge":"Yes","oa_version":"Published Version","quality_controlled":"1","_id":"14086","year":"2023","date_created":"2023-08-20T22:01:14Z","ec_funded":1,"title":"Faster submodular maximization for several classes of matroids","external_id":{"arxiv":["2305.00122"]},"project":[{"grant_number":"101019564","_id":"bd9ca328-d553-11ed-ba76-dc4f890cfe62","call_identifier":"H2020","name":"The design and evaluation of modern fully dynamic data structures"},{"grant_number":"I05982","_id":"bda196b2-d553-11ed-ba76-8e8ee6c21103","name":"Static and Dynamic Hierarchical Graph Decompositions"},{"grant_number":"P33775 ","_id":"bd9e3a2e-d553-11ed-ba76-8aa684ce17fe","name":"Fast Algorithms for a Reactive Network Layer"}],"article_number":"74","has_accepted_license":"1","date_updated":"2023-08-21T07:05:47Z","citation":{"short":"M.H. Henzinger, P. Liu, J. Vondrák, D.W. Zheng, in:, 50th International Colloquium on Automata, Languages, and Programming, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2023.","mla":"Henzinger, Monika H., et al. “Faster Submodular Maximization for Several Classes of Matroids.” <i>50th International Colloquium on Automata, Languages, and Programming</i>, vol. 261, 74, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2023, doi:<a href=\"https://doi.org/10.4230/LIPIcs.ICALP.2023.74\">10.4230/LIPIcs.ICALP.2023.74</a>.","ieee":"M. H. Henzinger, P. Liu, J. Vondrák, and D. W. Zheng, “Faster submodular maximization for several classes of matroids,” in <i>50th International Colloquium on Automata, Languages, and Programming</i>, Paderborn, Germany, 2023, vol. 261.","apa":"Henzinger, M. H., Liu, P., Vondrák, J., &#38; Zheng, D. W. (2023). Faster submodular maximization for several classes of matroids. In <i>50th International Colloquium on Automata, Languages, and Programming</i> (Vol. 261). Paderborn, Germany: Schloss Dagstuhl - Leibniz-Zentrum für Informatik. <a href=\"https://doi.org/10.4230/LIPIcs.ICALP.2023.74\">https://doi.org/10.4230/LIPIcs.ICALP.2023.74</a>","ama":"Henzinger MH, Liu P, Vondrák J, Zheng DW. Faster submodular maximization for several classes of matroids. In: <i>50th International Colloquium on Automata, Languages, and Programming</i>. Vol 261. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2023. doi:<a href=\"https://doi.org/10.4230/LIPIcs.ICALP.2023.74\">10.4230/LIPIcs.ICALP.2023.74</a>","chicago":"Henzinger, Monika H, Paul Liu, Jan Vondrák, and Da Wei Zheng. “Faster Submodular Maximization for Several Classes of Matroids.” In <i>50th International Colloquium on Automata, Languages, and Programming</i>, Vol. 261. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2023. <a href=\"https://doi.org/10.4230/LIPIcs.ICALP.2023.74\">https://doi.org/10.4230/LIPIcs.ICALP.2023.74</a>.","ista":"Henzinger MH, Liu P, Vondrák J, Zheng DW. 2023. Faster submodular maximization for several classes of matroids. 50th International Colloquium on Automata, Languages, and Programming. ICALP: International Colloquium on Automata, Languages, and Programming, LIPIcs, vol. 261, 74."},"author":[{"last_name":"Henzinger","first_name":"Monika H","orcid":"0000-0002-5008-6530","full_name":"Henzinger, Monika H","id":"540c9bbd-f2de-11ec-812d-d04a5be85630"},{"last_name":"Liu","first_name":"Paul","full_name":"Liu, Paul"},{"first_name":"Jan","last_name":"Vondrák","full_name":"Vondrák, Jan"},{"last_name":"Zheng","first_name":"Da Wei","full_name":"Zheng, Da Wei"}],"oa":1,"publication":"50th International Colloquium on Automata, Languages, and Programming","publication_identifier":{"issn":["18688969"],"isbn":["9783959772785"]},"day":"01"},{"_id":"14087","year":"2023","date_created":"2023-08-20T22:01:15Z","abstract":[{"text":"Polar active matter of self-propelled particles sustain spontaneous flows through the full-integer topological defects. We study theoretically the incompressible flow profiles around ±1 defects induced by polar and dipolar active forces. We show that dipolar forces induce vortical flows around the +1 defect, while the flow around the −1 defect has an 8-fold rotational symmetry. The vortical flow changes its chirality near the +1 defect core in the absence of the friction with a substrate. We show analytically that the flow induced by polar active forces is vortical near the +1 defect and is 4-fold symmetric near the −1 defect, while it becomes uniform in the far-field. For a pair of oppositely charged defects, this polar flow contributes to a mutual interaction force that depends only on the orientation of the defect pair relative to the background polarization, and that enhances defect pair annihilation. This is in contradiction with the effect of dipolar active forces which decay inversely proportional with the defect separation distance. As such, our analyses reveals a long-ranged mechanism for the pairwise interaction between topological defects in polar active matter.","lang":"eng"}],"file":[{"file_name":"2023_SoftMatter_Ronning.pdf","success":1,"relation":"main_file","date_created":"2024-01-30T12:48:24Z","file_id":"14908","date_updated":"2024-01-30T12:48:24Z","checksum":"b936747170d0b708172b518078c4081a","content_type":"application/pdf","file_size":7660662,"creator":"dernst","access_level":"open_access"}],"publication_status":"published","article_type":"original","article_processing_charge":"Yes (in subscription journal)","oa_version":"Published Version","quality_controlled":"1","date_updated":"2024-01-30T12:49:24Z","author":[{"first_name":"Jonas","last_name":"Rønning","full_name":"Rønning, Jonas"},{"last_name":"Renaud","first_name":"Julian B","id":"7af6767d-14eb-11ed-b536-a32449ae867c","full_name":"Renaud, Julian B"},{"first_name":"Amin","last_name":"Doostmohammadi","full_name":"Doostmohammadi, Amin"},{"last_name":"Angheluta","first_name":"Luiza","full_name":"Angheluta, Luiza"}],"citation":{"ista":"Rønning J, Renaud JB, Doostmohammadi A, Angheluta L. 2023. Spontaneous flows and dynamics of full-integer topological defects in polar active matter. Soft Matter. 39, 7513–7527.","chicago":"Rønning, Jonas, Julian B Renaud, Amin Doostmohammadi, and Luiza Angheluta. “Spontaneous Flows and Dynamics of Full-Integer Topological Defects in Polar Active Matter.” <i>Soft Matter</i>. Royal Society of Chemistry, 2023. <a href=\"https://doi.org/10.1039/d3sm00316g\">https://doi.org/10.1039/d3sm00316g</a>.","apa":"Rønning, J., Renaud, J. B., Doostmohammadi, A., &#38; Angheluta, L. (2023). Spontaneous flows and dynamics of full-integer topological defects in polar active matter. <i>Soft Matter</i>. Royal Society of Chemistry. <a href=\"https://doi.org/10.1039/d3sm00316g\">https://doi.org/10.1039/d3sm00316g</a>","ieee":"J. Rønning, J. B. Renaud, A. Doostmohammadi, and L. Angheluta, “Spontaneous flows and dynamics of full-integer topological defects in polar active matter,” <i>Soft Matter</i>, vol. 39. Royal Society of Chemistry, pp. 7513–7527, 2023.","ama":"Rønning J, Renaud JB, Doostmohammadi A, Angheluta L. Spontaneous flows and dynamics of full-integer topological defects in polar active matter. <i>Soft Matter</i>. 2023;39:7513-7527. doi:<a href=\"https://doi.org/10.1039/d3sm00316g\">10.1039/d3sm00316g</a>","mla":"Rønning, Jonas, et al. “Spontaneous Flows and Dynamics of Full-Integer Topological Defects in Polar Active Matter.” <i>Soft Matter</i>, vol. 39, Royal Society of Chemistry, 2023, pp. 7513–27, doi:<a href=\"https://doi.org/10.1039/d3sm00316g\">10.1039/d3sm00316g</a>.","short":"J. Rønning, J.B. Renaud, A. Doostmohammadi, L. Angheluta, Soft Matter 39 (2023) 7513–7527."},"oa":1,"publication":"Soft Matter","publication_identifier":{"issn":["1744-683X"],"eissn":["1744-6848"]},"day":"01","title":"Spontaneous flows and dynamics of full-integer topological defects in polar active matter","external_id":{"isi":["001035766100001"],"arxiv":["2303.07063"]},"has_accepted_license":"1","page":"7513-7527","arxiv":1,"scopus_import":"1","acknowledgement":"J. Rø and L. A. acknowledge support from the Research Council of Norway through the Center of Excellence funding scheme, Project No. 262644 (PoreLab). A. D. acknowledges funding from the Novo Nordisk Foundation (grant No. NNF18SA0035142 and NERD grant No. NNF21OC0068687), Villum Fonden Grant no. 29476, and the European Union via the ERC-Starting Grant PhysCoMeT. Views and opinions expressed are however those of the authors only and do not necessarily reflect those of the European Union or the European Research Council. Neither the European Union nor the granting authority can be held responsible for them.","month":"09","department":[{"_id":"GradSch"}],"publisher":"Royal Society of Chemistry","isi":1,"volume":39,"type":"journal_article","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","file_date_updated":"2024-01-30T12:48:24Z","status":"public","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"language":[{"iso":"eng"}],"date_published":"2023-09-01T00:00:00Z","doi":"10.1039/d3sm00316g","ddc":["540"],"intvolume":"        39"},{"external_id":{"arxiv":["2305.06376"]},"title":"X-shooting ULLYSES: Massive stars at low metallicity. I. Project description","article_number":"A154","author":[{"full_name":"Vink, Jorick S.","first_name":"Jorick S.","last_name":"Vink"},{"last_name":"Mehner","first_name":"A.","full_name":"Mehner, A."},{"last_name":"Crowther","first_name":"P. A.","full_name":"Crowther, P. A."},{"first_name":"A.","last_name":"Fullerton","full_name":"Fullerton, A."},{"first_name":"M.","last_name":"Garcia","full_name":"Garcia, M."},{"first_name":"F.","last_name":"Martins","full_name":"Martins, F."},{"full_name":"Morrell, N.","last_name":"Morrell","first_name":"N."},{"last_name":"Oskinova","first_name":"L. M.","full_name":"Oskinova, L. M."},{"full_name":"St-Louis, N.","first_name":"N.","last_name":"St-Louis"},{"last_name":"ud-Doula","first_name":"A.","full_name":"ud-Doula, A."},{"last_name":"Sander","first_name":"A. A. C.","full_name":"Sander, A. A. C."},{"last_name":"Sana","first_name":"H.","full_name":"Sana, H."},{"full_name":"Bouret, J.-C.","first_name":"J.-C.","last_name":"Bouret"},{"full_name":"Kubátová, B.","last_name":"Kubátová","first_name":"B."},{"full_name":"Marchant, P.","last_name":"Marchant","first_name":"P."},{"last_name":"Martins","first_name":"L. P.","full_name":"Martins, L. P."},{"full_name":"Wofford, A.","last_name":"Wofford","first_name":"A."},{"full_name":"van Loon, J. Th.","first_name":"J. Th.","last_name":"van Loon"},{"full_name":"Grace Telford, O.","last_name":"Grace Telford","first_name":"O."},{"last_name":"Götberg","first_name":"Ylva Louise Linsdotter","full_name":"Götberg, Ylva Louise Linsdotter","id":"d0648d0c-0f64-11ee-a2e0-dd0faa2e4f7d","orcid":"0000-0002-6960-6911"},{"first_name":"D. M.","last_name":"Bowman","full_name":"Bowman, D. M."},{"last_name":"Erba","first_name":"C.","full_name":"Erba, C."},{"full_name":"Kalari, V. M.","last_name":"Kalari","first_name":"V. M."},{"full_name":"Abdul-Masih, M.","first_name":"M.","last_name":"Abdul-Masih"},{"full_name":"Alkousa, T.","last_name":"Alkousa","first_name":"T."},{"last_name":"Backs","first_name":"F.","full_name":"Backs, F."},{"first_name":"C. L.","last_name":"Barbosa","full_name":"Barbosa, C. L."},{"last_name":"Berlanas","first_name":"S. R.","full_name":"Berlanas, S. R."},{"full_name":"Bernini-Peron, M.","first_name":"M.","last_name":"Bernini-Peron"},{"first_name":"J. M.","last_name":"Bestenlehner","full_name":"Bestenlehner, J. M."},{"full_name":"Blomme, R.","last_name":"Blomme","first_name":"R."},{"first_name":"J.","last_name":"Bodensteiner","full_name":"Bodensteiner, J."},{"first_name":"S. A.","last_name":"Brands","full_name":"Brands, S. A."},{"full_name":"Evans, C. J.","first_name":"C. J.","last_name":"Evans"},{"full_name":"David-Uraz, A.","first_name":"A.","last_name":"David-Uraz"},{"full_name":"Driessen, F. A.","first_name":"F. A.","last_name":"Driessen"},{"last_name":"Dsilva","first_name":"K.","full_name":"Dsilva, K."},{"first_name":"S.","last_name":"Geen","full_name":"Geen, S."},{"full_name":"Gómez-González, V. M. A.","first_name":"V. M. A.","last_name":"Gómez-González"},{"first_name":"L.","last_name":"Grassitelli","full_name":"Grassitelli, L."},{"last_name":"Hamann","first_name":"W.-R.","full_name":"Hamann, W.-R."},{"first_name":"C.","last_name":"Hawcroft","full_name":"Hawcroft, C."},{"last_name":"Herrero","first_name":"A.","full_name":"Herrero, A."},{"full_name":"Higgins, E. R.","first_name":"E. R.","last_name":"Higgins"},{"first_name":"D.","last_name":"John Hillier","full_name":"John Hillier, D."},{"first_name":"R.","last_name":"Ignace","full_name":"Ignace, R."},{"full_name":"Istrate, A. G.","last_name":"Istrate","first_name":"A. G."},{"first_name":"L.","last_name":"Kaper","full_name":"Kaper, L."},{"full_name":"Kee, N. D.","first_name":"N. D.","last_name":"Kee"},{"last_name":"Kehrig","first_name":"C.","full_name":"Kehrig, C."},{"first_name":"Z.","last_name":"Keszthelyi","full_name":"Keszthelyi, Z."},{"last_name":"Klencki","first_name":"J.","full_name":"Klencki, J."},{"full_name":"de Koter, A.","first_name":"A.","last_name":"de Koter"},{"full_name":"Kuiper, R.","first_name":"R.","last_name":"Kuiper"},{"last_name":"Laplace","first_name":"E.","full_name":"Laplace, E."},{"first_name":"C. J. K.","last_name":"Larkin","full_name":"Larkin, C. J. K."},{"full_name":"Lefever, R. R.","first_name":"R. R.","last_name":"Lefever"},{"last_name":"Leitherer","first_name":"C.","full_name":"Leitherer, C."},{"first_name":"D. J.","last_name":"Lennon","full_name":"Lennon, D. J."},{"full_name":"Mahy, L.","first_name":"L.","last_name":"Mahy"},{"full_name":"Maíz Apellániz, J.","first_name":"J.","last_name":"Maíz Apellániz"},{"last_name":"Maravelias","first_name":"G.","full_name":"Maravelias, G."},{"full_name":"Marcolino, W.","last_name":"Marcolino","first_name":"W."},{"full_name":"McLeod, A. F.","first_name":"A. F.","last_name":"McLeod"},{"full_name":"de Mink, S. E.","last_name":"de Mink","first_name":"S. E."},{"full_name":"Najarro, F.","first_name":"F.","last_name":"Najarro"},{"full_name":"Oey, M. S.","first_name":"M. S.","last_name":"Oey"},{"full_name":"Parsons, T. N.","first_name":"T. N.","last_name":"Parsons"},{"full_name":"Pauli, D.","first_name":"D.","last_name":"Pauli"},{"first_name":"M. G.","last_name":"Pedersen","full_name":"Pedersen, M. G."},{"full_name":"Prinja, R. K.","first_name":"R. K.","last_name":"Prinja"},{"last_name":"Ramachandran","first_name":"V.","full_name":"Ramachandran, V."},{"first_name":"M. C.","last_name":"Ramírez-Tannus","full_name":"Ramírez-Tannus, M. C."},{"last_name":"Sabhahit","first_name":"G. N.","full_name":"Sabhahit, G. N."},{"first_name":"A.","last_name":"Schootemeijer","full_name":"Schootemeijer, A."},{"full_name":"Reyero Serantes, S.","last_name":"Reyero Serantes","first_name":"S."},{"full_name":"Shenar, T.","last_name":"Shenar","first_name":"T."},{"last_name":"Stringfellow","first_name":"G. S.","full_name":"Stringfellow, G. S."},{"first_name":"N.","last_name":"Sudnik","full_name":"Sudnik, N."},{"last_name":"Tramper","first_name":"F.","full_name":"Tramper, F."},{"last_name":"Wang","first_name":"L.","full_name":"Wang, L."}],"date_updated":"2023-08-22T11:01:07Z","citation":{"mla":"Vink, Jorick S., et al. “X-Shooting ULLYSES: Massive Stars at Low Metallicity. I. Project Description.” <i>Astronomy &#38; Astrophysics</i>, vol. 675, A154, EDP Sciences, 2023, doi:<a href=\"https://doi.org/10.1051/0004-6361/202245650\">10.1051/0004-6361/202245650</a>.","apa":"Vink, J. S., Mehner, A., Crowther, P. A., Fullerton, A., Garcia, M., Martins, F., … Wang, L. (2023). X-shooting ULLYSES: Massive stars at low metallicity. I. Project description. <i>Astronomy &#38; Astrophysics</i>. EDP Sciences. <a href=\"https://doi.org/10.1051/0004-6361/202245650\">https://doi.org/10.1051/0004-6361/202245650</a>","ieee":"J. S. Vink <i>et al.</i>, “X-shooting ULLYSES: Massive stars at low metallicity. I. Project description,” <i>Astronomy &#38; Astrophysics</i>, vol. 675. EDP Sciences, 2023.","ama":"Vink JS, Mehner A, Crowther PA, et al. X-shooting ULLYSES: Massive stars at low metallicity. I. Project description. <i>Astronomy &#38; Astrophysics</i>. 2023;675. doi:<a href=\"https://doi.org/10.1051/0004-6361/202245650\">10.1051/0004-6361/202245650</a>","chicago":"Vink, Jorick S., A. Mehner, P. A. Crowther, A. Fullerton, M. Garcia, F. Martins, N. Morrell, et al. “X-Shooting ULLYSES: Massive Stars at Low Metallicity. I. Project Description.” <i>Astronomy &#38; Astrophysics</i>. EDP Sciences, 2023. <a href=\"https://doi.org/10.1051/0004-6361/202245650\">https://doi.org/10.1051/0004-6361/202245650</a>.","ista":"Vink JS, Mehner A, Crowther PA, Fullerton A, Garcia M, Martins F, Morrell N, Oskinova LM, St-Louis N, ud-Doula A, Sander AAC, Sana H, Bouret J-C, Kubátová B, Marchant P, Martins LP, Wofford A, van Loon JT, Grace Telford O, Götberg YLL, Bowman DM, Erba C, Kalari VM, Abdul-Masih M, Alkousa T, Backs F, Barbosa CL, Berlanas SR, Bernini-Peron M, Bestenlehner JM, Blomme R, Bodensteiner J, Brands SA, Evans CJ, David-Uraz A, Driessen FA, Dsilva K, Geen S, Gómez-González VMA, Grassitelli L, Hamann W-R, Hawcroft C, Herrero A, Higgins ER, John Hillier D, Ignace R, Istrate AG, Kaper L, Kee ND, Kehrig C, Keszthelyi Z, Klencki J, de Koter A, Kuiper R, Laplace E, Larkin CJK, Lefever RR, Leitherer C, Lennon DJ, Mahy L, Maíz Apellániz J, Maravelias G, Marcolino W, McLeod AF, de Mink SE, Najarro F, Oey MS, Parsons TN, Pauli D, Pedersen MG, Prinja RK, Ramachandran V, Ramírez-Tannus MC, Sabhahit GN, Schootemeijer A, Reyero Serantes S, Shenar T, Stringfellow GS, Sudnik N, Tramper F, Wang L. 2023. X-shooting ULLYSES: Massive stars at low metallicity. I. Project description. Astronomy &#38; Astrophysics. 675, A154.","short":"J.S. Vink, A. Mehner, P.A. Crowther, A. Fullerton, M. Garcia, F. Martins, N. Morrell, L.M. Oskinova, N. St-Louis, A. ud-Doula, A.A.C. Sander, H. Sana, J.-C. Bouret, B. Kubátová, P. Marchant, L.P. Martins, A. Wofford, J.T. van Loon, O. Grace Telford, Y.L.L. Götberg, D.M. Bowman, C. Erba, V.M. Kalari, M. Abdul-Masih, T. Alkousa, F. Backs, C.L. Barbosa, S.R. Berlanas, M. Bernini-Peron, J.M. Bestenlehner, R. Blomme, J. Bodensteiner, S.A. Brands, C.J. Evans, A. David-Uraz, F.A. Driessen, K. Dsilva, S. Geen, V.M.A. Gómez-González, L. Grassitelli, W.-R. Hamann, C. Hawcroft, A. Herrero, E.R. Higgins, D. John Hillier, R. Ignace, A.G. Istrate, L. Kaper, N.D. Kee, C. Kehrig, Z. Keszthelyi, J. Klencki, A. de Koter, R. Kuiper, E. Laplace, C.J.K. Larkin, R.R. Lefever, C. Leitherer, D.J. Lennon, L. Mahy, J. Maíz Apellániz, G. Maravelias, W. Marcolino, A.F. McLeod, S.E. de Mink, F. Najarro, M.S. Oey, T.N. Parsons, D. Pauli, M.G. Pedersen, R.K. Prinja, V. Ramachandran, M.C. Ramírez-Tannus, G.N. Sabhahit, A. Schootemeijer, S. Reyero Serantes, T. Shenar, G.S. Stringfellow, N. Sudnik, F. Tramper, L. Wang, Astronomy &#38; Astrophysics 675 (2023)."},"publication_identifier":{"eissn":["1432-0746"],"issn":["0004-6361"]},"publication":"Astronomy & Astrophysics","oa":1,"day":"01","abstract":[{"text":"Observations of individual massive stars, super-luminous supernovae, gamma-ray bursts, and gravitational wave events involving spectacular black hole mergers indicate that the low-metallicity Universe is fundamentally different from our own Galaxy. Many transient phenomena will remain enigmatic until we achieve a firm understanding of the physics and evolution of massive stars at low metallicity (Z). The Hubble Space Telescope has devoted 500 orbits to observing ∼250 massive stars at low Z in the ultraviolet (UV) with the COS and STIS spectrographs under the ULLYSES programme. The complementary X-Shooting ULLYSES (XShootU) project provides an enhanced legacy value with high-quality optical and near-infrared spectra obtained with the wide-wavelength coverage X-shooter spectrograph at ESO’s Very Large Telescope. We present an overview of the XShootU project, showing that combining ULLYSES UV and XShootU optical spectra is critical for the uniform determination of stellar parameters such as effective temperature, surface gravity, luminosity, and abundances, as well as wind properties such as mass-loss rates as a function of Z. As uncertainties in stellar and wind parameters percolate into many adjacent areas of astrophysics, the data and modelling of the XShootU project is expected to be a game changer for our physical understanding of massive stars at low Z. To be able to confidently interpret James Webb Space Telescope spectra of the first stellar generations, the individual spectra of low-Z stars need to be understood, which is exactly where XShootU can deliver.","lang":"eng"}],"publication_status":"published","article_type":"original","oa_version":"Published Version","keyword":["Space and Planetary Science","Astronomy and Astrophysics"],"article_processing_charge":"No","quality_controlled":"1","year":"2023","_id":"14103","date_created":"2023-08-21T10:12:35Z","language":[{"iso":"eng"}],"status":"public","doi":"10.1051/0004-6361/202245650","date_published":"2023-07-01T00:00:00Z","intvolume":"       675","extern":"1","volume":675,"type":"journal_article","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"EDP Sciences","month":"07","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1051/0004-6361/202245650"}],"arxiv":1,"scopus_import":"1"},{"author":[{"first_name":"R","last_name":"Farmer","full_name":"Farmer, R"},{"full_name":"Renzo, M","first_name":"M","last_name":"Renzo"},{"orcid":"0000-0002-6960-6911","full_name":"Götberg, Ylva Louise Linsdotter","id":"d0648d0c-0f64-11ee-a2e0-dd0faa2e4f7d","first_name":"Ylva Louise Linsdotter","last_name":"Götberg"},{"full_name":"Bellinger, E","first_name":"E","last_name":"Bellinger"},{"full_name":"Justham, S","first_name":"S","last_name":"Justham"},{"full_name":"de Mink, S E","first_name":"S E","last_name":"de Mink"}],"citation":{"ista":"Farmer R, Renzo M, Götberg YLL, Bellinger E, Justham S, de Mink SE. 2023. Observational predictions for Thorne–Żytkow objects. Monthly Notices of the Royal Astronomical Society. 524(2), 1692–1709.","chicago":"Farmer, R, M Renzo, Ylva Louise Linsdotter Götberg, E Bellinger, S Justham, and S E de Mink. “Observational Predictions for Thorne–Żytkow Objects.” <i>Monthly Notices of the Royal Astronomical Society</i>. Oxford University Press, 2023. <a href=\"https://doi.org/10.1093/mnras/stad1977\">https://doi.org/10.1093/mnras/stad1977</a>.","ama":"Farmer R, Renzo M, Götberg YLL, Bellinger E, Justham S, de Mink SE. Observational predictions for Thorne–Żytkow objects. <i>Monthly Notices of the Royal Astronomical Society</i>. 2023;524(2):1692-1709. doi:<a href=\"https://doi.org/10.1093/mnras/stad1977\">10.1093/mnras/stad1977</a>","ieee":"R. Farmer, M. Renzo, Y. L. L. Götberg, E. Bellinger, S. Justham, and S. E. de Mink, “Observational predictions for Thorne–Żytkow objects,” <i>Monthly Notices of the Royal Astronomical Society</i>, vol. 524, no. 2. Oxford University Press, pp. 1692–1709, 2023.","apa":"Farmer, R., Renzo, M., Götberg, Y. L. L., Bellinger, E., Justham, S., &#38; de Mink, S. E. (2023). Observational predictions for Thorne–Żytkow objects. <i>Monthly Notices of the Royal Astronomical Society</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/mnras/stad1977\">https://doi.org/10.1093/mnras/stad1977</a>","mla":"Farmer, R., et al. “Observational Predictions for Thorne–Żytkow Objects.” <i>Monthly Notices of the Royal Astronomical Society</i>, vol. 524, no. 2, Oxford University Press, 2023, pp. 1692–709, doi:<a href=\"https://doi.org/10.1093/mnras/stad1977\">10.1093/mnras/stad1977</a>.","short":"R. Farmer, M. Renzo, Y.L.L. Götberg, E. Bellinger, S. Justham, S.E. de Mink, Monthly Notices of the Royal Astronomical Society 524 (2023) 1692–1709."},"date_updated":"2023-08-21T12:12:48Z","publication":"Monthly Notices of the Royal Astronomical Society","publication_identifier":{"eissn":["1365-2966"],"issn":["0035-8711"]},"oa":1,"day":"01","external_id":{"arxiv":["2305.07337"]},"title":"Observational predictions for Thorne–Żytkow objects","issue":"2","year":"2023","_id":"14104","date_created":"2023-08-21T10:13:56Z","abstract":[{"text":"Thorne–Żytkow objects (TŻO) are potential end products of the merger of a neutron star with a non-degenerate star. In this work, we have computed the first grid of evolutionary models of TŻOs with the MESA stellar evolution code. With these models, we predict several observational properties of TŻOs, including their surface temperatures and luminosities, pulsation periods, and nucleosynthetic products. We expand the range of possible TŻO solutions to cover 3.45≲log(Teff/K)≲3.65 and 4.85≲log(L/L⊙)≲5.5⁠. Due to the much higher densities our TŻOs reach compared to previous models, if TŻOs form we expect them to be stable over a larger mass range than previously predicted, without exhibiting a gap in their mass distribution. Using the GYRE stellar pulsation code we show that TŻOs should have fundamental pulsation periods of 1000–2000 d, and period ratios of ≈0.2–0.3. Models computed with a large 399 isotope fully coupled nuclear network show a nucleosynthetic signal that is different to previously predicted. We propose a new nucleosynthetic signal to determine a star’s status as a TŻO: the isotopologues 44TiO2 and 44TiO⁠, which will have a shift in their spectral features as compared to stable titanium-containing molecules. We find that in the local Universe (∼SMC metallicities and above) TŻOs show little heavy metal enrichment, potentially explaining the difficulty in finding TŻOs to-date.","lang":"eng"}],"publication_status":"published","article_type":"original","oa_version":"Preprint","article_processing_charge":"No","keyword":["Space and Planetary Science","Astronomy and Astrophysics"],"quality_controlled":"1","volume":524,"type":"journal_article","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","language":[{"iso":"eng"}],"status":"public","doi":"10.1093/mnras/stad1977","date_published":"2023-09-01T00:00:00Z","intvolume":"       524","extern":"1","page":"1692-1709","arxiv":1,"scopus_import":"1","publisher":"Oxford University Press","month":"09","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/2305.07337"}]}]