[{"publication_status":"published","quality_controlled":"1","_id":"7717","abstract":[{"text":"Background: DNA methylation levels change along with age, but few studies have examined the variation in the rate of such changes between individuals.\r\nMethods: We performed a longitudinal analysis to quantify the variation in the rate of change of DNA methylation between individuals using whole blood DNA methylation array profiles collected at 2–4 time points (N = 2894) in 954 individuals (67–90 years).\r\nResults: After stringent quality control, we identified 1507 DNA methylation CpG sites (rsCpGs) with statistically significant variation in the rate of change (random slope) of DNA methylation among individuals in a mixed linear model analysis. Genes in the vicinity of these rsCpGs were found to be enriched in Homeobox transcription factors and the Wnt signalling pathway, both of which are related to ageing processes. Furthermore, we investigated the SNP effect on the random slope. We found that 4 out of 1507 rsCpGs had one significant (P < 5 × 10−8/1507) SNP effect and 343 rsCpGs had at least one SNP effect (436 SNP-probe pairs) reaching genome-wide significance (P < 5 × 10−8). Ninety-five percent of the significant (P < 5 × 10−8) SNPs are on different chromosomes from their corresponding probes.\r\nConclusions: We identified CpG sites that have variability in the rate of change of DNA methylation between individuals, and our results suggest a genetic basis of this variation. Genes around these CpG sites have been reported to be involved in the ageing process.","lang":"eng"}],"type":"journal_article","citation":{"short":"Q. Zhang, R.E. Marioni, M.R. Robinson, J. Higham, D. Sproul, N.R. Wray, I.J. Deary, A.F. McRae, P.M. Visscher, Genome Medicine 10 (2018).","ista":"Zhang Q, Marioni RE, Robinson MR, Higham J, Sproul D, Wray NR, Deary IJ, McRae AF, Visscher PM. 2018. Genotype effects contribute to variation in longitudinal methylome patterns in older people. Genome Medicine. 10(1), 75.","ieee":"Q. Zhang <i>et al.</i>, “Genotype effects contribute to variation in longitudinal methylome patterns in older people,” <i>Genome Medicine</i>, vol. 10, no. 1. Springer Nature, 2018.","ama":"Zhang Q, Marioni RE, Robinson MR, et al. Genotype effects contribute to variation in longitudinal methylome patterns in older people. <i>Genome Medicine</i>. 2018;10(1). doi:<a href=\"https://doi.org/10.1186/s13073-018-0585-7\">10.1186/s13073-018-0585-7</a>","chicago":"Zhang, Qian, Riccardo E Marioni, Matthew Richard Robinson, Jon Higham, Duncan Sproul, Naomi R Wray, Ian J Deary, Allan F McRae, and Peter M Visscher. “Genotype Effects Contribute to Variation in Longitudinal Methylome Patterns in Older People.” <i>Genome Medicine</i>. Springer Nature, 2018. <a href=\"https://doi.org/10.1186/s13073-018-0585-7\">https://doi.org/10.1186/s13073-018-0585-7</a>.","apa":"Zhang, Q., Marioni, R. E., Robinson, M. R., Higham, J., Sproul, D., Wray, N. R., … Visscher, P. M. (2018). Genotype effects contribute to variation in longitudinal methylome patterns in older people. <i>Genome Medicine</i>. Springer Nature. <a href=\"https://doi.org/10.1186/s13073-018-0585-7\">https://doi.org/10.1186/s13073-018-0585-7</a>","mla":"Zhang, Qian, et al. “Genotype Effects Contribute to Variation in Longitudinal Methylome Patterns in Older People.” <i>Genome Medicine</i>, vol. 10, no. 1, 75, Springer Nature, 2018, doi:<a href=\"https://doi.org/10.1186/s13073-018-0585-7\">10.1186/s13073-018-0585-7</a>."},"publication_identifier":{"issn":["1756-994X"]},"extern":"1","article_type":"original","language":[{"iso":"eng"}],"article_processing_charge":"No","author":[{"last_name":"Zhang","first_name":"Qian","full_name":"Zhang, Qian"},{"last_name":"Marioni","first_name":"Riccardo E","full_name":"Marioni, Riccardo E"},{"full_name":"Robinson, Matthew Richard","id":"E5D42276-F5DA-11E9-8E24-6303E6697425","first_name":"Matthew Richard","last_name":"Robinson","orcid":"0000-0001-8982-8813"},{"first_name":"Jon","last_name":"Higham","full_name":"Higham, Jon"},{"full_name":"Sproul, Duncan","last_name":"Sproul","first_name":"Duncan"},{"full_name":"Wray, Naomi R","last_name":"Wray","first_name":"Naomi R"},{"full_name":"Deary, Ian J","last_name":"Deary","first_name":"Ian J"},{"full_name":"McRae, Allan F","last_name":"McRae","first_name":"Allan F"},{"full_name":"Visscher, Peter M","last_name":"Visscher","first_name":"Peter M"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Genotype effects contribute to variation in longitudinal methylome patterns in older people","publisher":"Springer Nature","oa_version":"Published Version","publication":"Genome Medicine","doi":"10.1186/s13073-018-0585-7","main_file_link":[{"url":"https://doi.org/10.1186/s13073-018-0585-7","open_access":"1"}],"status":"public","day":"22","date_created":"2020-04-30T10:42:50Z","volume":10,"year":"2018","oa":1,"issue":"1","date_updated":"2021-01-12T08:15:04Z","article_number":"75","date_published":"2018-10-22T00:00:00Z","intvolume":"        10","month":"10"},{"publisher":"American Association for the Advancement of Science","author":[{"full_name":"Tucci, Serena","first_name":"Serena","last_name":"Tucci"},{"last_name":"Vohr","first_name":"Samuel H.","full_name":"Vohr, Samuel H."},{"last_name":"McCoy","first_name":"Rajiv C.","full_name":"McCoy, Rajiv C."},{"last_name":"Vernot","first_name":"Benjamin","full_name":"Vernot, Benjamin"},{"full_name":"Robinson, Matthew Richard","orcid":"0000-0001-8982-8813","last_name":"Robinson","id":"E5D42276-F5DA-11E9-8E24-6303E6697425","first_name":"Matthew Richard"},{"last_name":"Barbieri","first_name":"Chiara","full_name":"Barbieri, Chiara"},{"first_name":"Brad J.","last_name":"Nelson","full_name":"Nelson, Brad J."},{"first_name":"Wenqing","last_name":"Fu","full_name":"Fu, Wenqing"},{"full_name":"Purnomo, Gludhug A.","last_name":"Purnomo","first_name":"Gludhug A."},{"full_name":"Sudoyo, Herawati","first_name":"Herawati","last_name":"Sudoyo"},{"full_name":"Eichler, Evan E.","last_name":"Eichler","first_name":"Evan E."},{"first_name":"Guido","last_name":"Barbujani","full_name":"Barbujani, Guido"},{"last_name":"Visscher","first_name":"Peter M.","full_name":"Visscher, Peter M."},{"first_name":"Joshua M.","last_name":"Akey","full_name":"Akey, Joshua M."},{"full_name":"Green, Richard E.","first_name":"Richard E.","last_name":"Green"}],"title":"Evolutionary history and adaptation of a human pygmy population of Flores Island, Indonesia","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_processing_charge":"No","article_type":"original","language":[{"iso":"eng"}],"type":"journal_article","abstract":[{"text":"Flores Island, Indonesia, was inhabited by the small-bodied hominin species Homo floresiensis, which has an unknown evolutionary relationship to modern humans. This island is also home to an extant human pygmy population. Here we describe genome-scale single-nucleotide polymorphism data and whole-genome sequences from a contemporary human pygmy population living on Flores near the cave where H. floresiensis was found. The genomes of Flores pygmies reveal a complex history of admixture with Denisovans and Neanderthals but no evidence for gene flow with other archaic hominins. Modern individuals bear the signatures of recent positive selection encompassing the FADS (fatty acid desaturase) gene cluster, likely related to diet, and polygenic selection acting on standing variation that contributed to their short-stature phenotype. Thus, multiple independent instances of hominin insular dwarfism occurred on Flores.","lang":"eng"}],"citation":{"chicago":"Tucci, Serena, Samuel H. Vohr, Rajiv C. McCoy, Benjamin Vernot, Matthew Richard Robinson, Chiara Barbieri, Brad J. Nelson, et al. “Evolutionary History and Adaptation of a Human Pygmy Population of Flores Island, Indonesia.” <i>Science</i>. American Association for the Advancement of Science, 2018. <a href=\"https://doi.org/10.1126/science.aar8486\">https://doi.org/10.1126/science.aar8486</a>.","ama":"Tucci S, Vohr SH, McCoy RC, et al. Evolutionary history and adaptation of a human pygmy population of Flores Island, Indonesia. <i>Science</i>. 2018;361(6401):511-516. doi:<a href=\"https://doi.org/10.1126/science.aar8486\">10.1126/science.aar8486</a>","short":"S. Tucci, S.H. Vohr, R.C. McCoy, B. Vernot, M.R. Robinson, C. Barbieri, B.J. Nelson, W. Fu, G.A. Purnomo, H. Sudoyo, E.E. Eichler, G. Barbujani, P.M. Visscher, J.M. Akey, R.E. Green, Science 361 (2018) 511–516.","ista":"Tucci S, Vohr SH, McCoy RC, Vernot B, Robinson MR, Barbieri C, Nelson BJ, Fu W, Purnomo GA, Sudoyo H, Eichler EE, Barbujani G, Visscher PM, Akey JM, Green RE. 2018. Evolutionary history and adaptation of a human pygmy population of Flores Island, Indonesia. Science. 361(6401), 511–516.","ieee":"S. Tucci <i>et al.</i>, “Evolutionary history and adaptation of a human pygmy population of Flores Island, Indonesia,” <i>Science</i>, vol. 361, no. 6401. American Association for the Advancement of Science, pp. 511–516, 2018.","mla":"Tucci, Serena, et al. “Evolutionary History and Adaptation of a Human Pygmy Population of Flores Island, Indonesia.” <i>Science</i>, vol. 361, no. 6401, American Association for the Advancement of Science, 2018, pp. 511–16, doi:<a href=\"https://doi.org/10.1126/science.aar8486\">10.1126/science.aar8486</a>.","apa":"Tucci, S., Vohr, S. H., McCoy, R. C., Vernot, B., Robinson, M. R., Barbieri, C., … Green, R. E. (2018). Evolutionary history and adaptation of a human pygmy population of Flores Island, Indonesia. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.aar8486\">https://doi.org/10.1126/science.aar8486</a>"},"extern":"1","publication_identifier":{"issn":["0036-8075","1095-9203"]},"quality_controlled":"1","_id":"7718","publication_status":"published","month":"08","intvolume":"       361","date_published":"2018-08-03T00:00:00Z","issue":"6401","date_updated":"2021-01-12T08:15:04Z","page":"511-516","external_id":{"pmid":["30072539"]},"year":"2018","pmid":1,"volume":361,"status":"public","day":"03","date_created":"2020-04-30T10:43:24Z","doi":"10.1126/science.aar8486","publication":"Science","oa_version":"None"},{"volume":48,"date_created":"2020-04-30T10:44:35Z","day":"01","status":"public","publication":"Psychological Medicine","doi":"10.1017/s0033291717002318","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1017/s0033291717002318"}],"oa_version":"Published Version","date_published":"2018-05-01T00:00:00Z","month":"05","intvolume":"        48","date_updated":"2021-01-12T08:15:05Z","oa":1,"issue":"7","page":"1055-1067","year":"2018","publication_identifier":{"issn":["0033-2917","1469-8978"]},"citation":{"chicago":"Maier, R. M., P. M. Visscher, Matthew Richard Robinson, and N. R. Wray. “Embracing Polygenicity: A Review of Methods and Tools for Psychiatric Genetics Research.” <i>Psychological Medicine</i>. Cambridge University Press, 2018. <a href=\"https://doi.org/10.1017/s0033291717002318\">https://doi.org/10.1017/s0033291717002318</a>.","short":"R.M. Maier, P.M. Visscher, M.R. Robinson, N.R. Wray, Psychological Medicine 48 (2018) 1055–1067.","ista":"Maier RM, Visscher PM, Robinson MR, Wray NR. 2018. Embracing polygenicity: A review of methods and tools for psychiatric genetics research. Psychological Medicine. 48(7), 1055–1067.","ieee":"R. M. Maier, P. M. Visscher, M. R. Robinson, and N. R. Wray, “Embracing polygenicity: A review of methods and tools for psychiatric genetics research,” <i>Psychological Medicine</i>, vol. 48, no. 7. Cambridge University Press, pp. 1055–1067, 2018.","ama":"Maier RM, Visscher PM, Robinson MR, Wray NR. Embracing polygenicity: A review of methods and tools for psychiatric genetics research. <i>Psychological Medicine</i>. 2018;48(7):1055-1067. doi:<a href=\"https://doi.org/10.1017/s0033291717002318\">10.1017/s0033291717002318</a>","mla":"Maier, R. M., et al. “Embracing Polygenicity: A Review of Methods and Tools for Psychiatric Genetics Research.” <i>Psychological Medicine</i>, vol. 48, no. 7, Cambridge University Press, 2018, pp. 1055–67, doi:<a href=\"https://doi.org/10.1017/s0033291717002318\">10.1017/s0033291717002318</a>.","apa":"Maier, R. M., Visscher, P. M., Robinson, M. R., &#38; Wray, N. R. (2018). Embracing polygenicity: A review of methods and tools for psychiatric genetics research. <i>Psychological Medicine</i>. Cambridge University Press. <a href=\"https://doi.org/10.1017/s0033291717002318\">https://doi.org/10.1017/s0033291717002318</a>"},"extern":"1","abstract":[{"text":"The availability of genome-wide genetic data on hundreds of thousands of people has led to an equally rapid growth in methodologies available to analyse these data. While the motivation for undertaking genome-wide association studies (GWAS) is identification of genetic markers associated with complex traits, once generated these data can be used for many other analyses. GWAS have demonstrated that complex traits exhibit a highly polygenic genetic architecture, often with shared genetic risk factors across traits. New methods to analyse data from GWAS are increasingly being used to address a diverse set of questions about the aetiology of complex traits and diseases, including psychiatric disorders. Here, we give an overview of some of these methods and present examples of how they have contributed to our understanding of psychiatric disorders. We consider: (i) estimation of the extent of genetic influence on traits, (ii) uncovering of shared genetic control between traits, (iii) predictions of genetic risk for individuals, (iv) uncovering of causal relationships between traits, (v) identifying causal single-nucleotide polymorphisms and genes or (vi) the detection of genetic heterogeneity. This classification helps organise the large number of recently developed methods, although some could be placed in more than one category. While some methods require GWAS data on individual people, others simply use GWAS summary statistics data, allowing novel well-powered analyses to be conducted at a low computational burden.","lang":"eng"}],"type":"journal_article","_id":"7721","quality_controlled":"1","publication_status":"published","publisher":"Cambridge University Press","author":[{"full_name":"Maier, R. M.","first_name":"R. M.","last_name":"Maier"},{"first_name":"P. M.","last_name":"Visscher","full_name":"Visscher, P. M."},{"orcid":"0000-0001-8982-8813","last_name":"Robinson","first_name":"Matthew Richard","id":"E5D42276-F5DA-11E9-8E24-6303E6697425","full_name":"Robinson, Matthew Richard"},{"first_name":"N. R.","last_name":"Wray","full_name":"Wray, N. R."}],"title":"Embracing polygenicity: A review of methods and tools for psychiatric genetics research","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_processing_charge":"No","language":[{"iso":"eng"}],"article_type":"original"},{"date_created":"2020-04-30T10:44:57Z","_id":"7722","quality_controlled":"1","status":"public","day":"16","volume":50,"extern":"1","citation":{"mla":"Zeng, Jian, et al. “Signatures of Negative Selection in the Genetic Architecture of Human Complex Traits.” <i>Nature Genetics</i>, vol. 50, no. 5, Springer Nature, 2018, pp. 746–53, doi:<a href=\"https://doi.org/10.1038/s41588-018-0101-4\">10.1038/s41588-018-0101-4</a>.","apa":"Zeng, J., de Vlaming, R., Wu, Y., Robinson, M. R., Lloyd-Jones, L. R., Yengo, L., … Yang, J. (2018). Signatures of negative selection in the genetic architecture of human complex traits. <i>Nature Genetics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41588-018-0101-4\">https://doi.org/10.1038/s41588-018-0101-4</a>","chicago":"Zeng, Jian, Ronald de Vlaming, Yang Wu, Matthew Richard Robinson, Luke R. Lloyd-Jones, Loic Yengo, Chloe X. Yap, et al. “Signatures of Negative Selection in the Genetic Architecture of Human Complex Traits.” <i>Nature Genetics</i>. Springer Nature, 2018. <a href=\"https://doi.org/10.1038/s41588-018-0101-4\">https://doi.org/10.1038/s41588-018-0101-4</a>.","short":"J. Zeng, R. de Vlaming, Y. Wu, M.R. Robinson, L.R. Lloyd-Jones, L. Yengo, C.X. Yap, A. Xue, J. Sidorenko, A.F. McRae, J.E. Powell, G.W. Montgomery, A. Metspalu, T. Esko, G. Gibson, N.R. Wray, P.M. Visscher, J. Yang, Nature Genetics 50 (2018) 746–753.","ieee":"J. Zeng <i>et al.</i>, “Signatures of negative selection in the genetic architecture of human complex traits,” <i>Nature Genetics</i>, vol. 50, no. 5. Springer Nature, pp. 746–753, 2018.","ista":"Zeng J, de Vlaming R, Wu Y, Robinson MR, Lloyd-Jones LR, Yengo L, Yap CX, Xue A, Sidorenko J, McRae AF, Powell JE, Montgomery GW, Metspalu A, Esko T, Gibson G, Wray NR, Visscher PM, Yang J. 2018. Signatures of negative selection in the genetic architecture of human complex traits. Nature Genetics. 50(5), 746–753.","ama":"Zeng J, de Vlaming R, Wu Y, et al. Signatures of negative selection in the genetic architecture of human complex traits. <i>Nature Genetics</i>. 2018;50(5):746-753. doi:<a href=\"https://doi.org/10.1038/s41588-018-0101-4\">10.1038/s41588-018-0101-4</a>"},"publication_identifier":{"issn":["1061-4036","1546-1718"]},"abstract":[{"lang":"eng","text":"We develop a Bayesian mixed linear model that simultaneously estimates single-nucleotide polymorphism (SNP)-based heritability, polygenicity (proportion of SNPs with nonzero effects), and the relationship between SNP effect size and minor allele frequency for complex traits in conventionally unrelated individuals using genome-wide SNP data. We apply the method to 28 complex traits in the UK Biobank data (N = 126,752) and show that on average, 6% of SNPs have nonzero effects, which in total explain 22% of phenotypic variance. We detect significant (P < 0.05/28) signatures of natural selection in the genetic architecture of 23 traits, including reproductive, cardiovascular, and anthropometric traits, as well as educational attainment. The significant estimates of the relationship between effect size and minor allele frequency in complex traits are consistent with a model of negative (or purifying) selection, as confirmed by forward simulation. We conclude that negative selection acts pervasively on the genetic variants associated with human complex traits."}],"type":"journal_article","oa_version":"None","publication":"Nature Genetics","publication_status":"published","doi":"10.1038/s41588-018-0101-4","date_updated":"2021-01-12T08:15:06Z","author":[{"full_name":"Zeng, Jian","first_name":"Jian","last_name":"Zeng"},{"full_name":"de Vlaming, Ronald","first_name":"Ronald","last_name":"de Vlaming"},{"full_name":"Wu, Yang","last_name":"Wu","first_name":"Yang"},{"id":"E5D42276-F5DA-11E9-8E24-6303E6697425","first_name":"Matthew Richard","orcid":"0000-0001-8982-8813","last_name":"Robinson","full_name":"Robinson, Matthew Richard"},{"first_name":"Luke R.","last_name":"Lloyd-Jones","full_name":"Lloyd-Jones, Luke R."},{"last_name":"Yengo","first_name":"Loic","full_name":"Yengo, Loic"},{"first_name":"Chloe X.","last_name":"Yap","full_name":"Yap, Chloe X."},{"first_name":"Angli","last_name":"Xue","full_name":"Xue, Angli"},{"full_name":"Sidorenko, Julia","first_name":"Julia","last_name":"Sidorenko"},{"first_name":"Allan F.","last_name":"McRae","full_name":"McRae, Allan F."},{"last_name":"Powell","first_name":"Joseph E.","full_name":"Powell, Joseph E."},{"first_name":"Grant W.","last_name":"Montgomery","full_name":"Montgomery, Grant W."},{"full_name":"Metspalu, Andres","last_name":"Metspalu","first_name":"Andres"},{"first_name":"Tonu","last_name":"Esko","full_name":"Esko, Tonu"},{"first_name":"Greg","last_name":"Gibson","full_name":"Gibson, Greg"},{"full_name":"Wray, Naomi R.","last_name":"Wray","first_name":"Naomi R."},{"full_name":"Visscher, Peter M.","last_name":"Visscher","first_name":"Peter M."},{"full_name":"Yang, Jian","first_name":"Jian","last_name":"Yang"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Signatures of negative selection in the genetic architecture of human complex traits","issue":"5","date_published":"2018-04-16T00:00:00Z","intvolume":"        50","month":"04","publisher":"Springer Nature","language":[{"iso":"eng"}],"article_type":"original","year":"2018","article_processing_charge":"No","page":"746-753"},{"page":"1397-1408","article_processing_charge":"No","year":"2018","article_type":"original","language":[{"iso":"eng"}],"publisher":"Genetics Society of America","intvolume":"       208","month":"04","date_published":"2018-04-01T00:00:00Z","issue":"4","title":"Transformation of summary statistics from linear mixed model association on all-or-none traits to odds ratio","author":[{"last_name":"Lloyd-Jones","first_name":"Luke R.","full_name":"Lloyd-Jones, Luke R."},{"full_name":"Robinson, Matthew Richard","orcid":"0000-0001-8982-8813","last_name":"Robinson","id":"E5D42276-F5DA-11E9-8E24-6303E6697425","first_name":"Matthew Richard"},{"last_name":"Yang","first_name":"Jian","full_name":"Yang, Jian"},{"last_name":"Visscher","first_name":"Peter M.","full_name":"Visscher, Peter M."}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2021-01-12T08:15:06Z","doi":"10.1534/genetics.117.300360","publication_status":"published","publication":"Genetics","oa_version":"None","type":"journal_article","abstract":[{"text":"Genome-wide association studies (GWAS) have identified thousands of loci that are robustly associated with complex diseases. The use of linear mixed model (LMM) methodology for GWAS is becoming more prevalent due to its ability to control for population structure and cryptic relatedness and to increase power. The odds ratio (OR) is a common measure of the association of a disease with an exposure (e.g., a genetic variant) and is readably available from logistic regression. However, when the LMM is applied to all-or-none traits it provides estimates of genetic effects on the observed 0–1 scale, a different scale to that in logistic regression. This limits the comparability of results across studies, for example in a meta-analysis, and makes the interpretation of the magnitude of an effect from an LMM GWAS difficult. In this study, we derived transformations from the genetic effects estimated under the LMM to the OR that only rely on summary statistics. To test the proposed transformations, we used real genotypes from two large, publicly available data sets to simulate all-or-none phenotypes for a set of scenarios that differ in underlying model, disease prevalence, and heritability. Furthermore, we applied these transformations to GWAS summary statistics for type 2 diabetes generated from 108,042 individuals in the UK Biobank. In both simulation and real-data application, we observed very high concordance between the transformed OR from the LMM and either the simulated truth or estimates from logistic regression. The transformations derived and validated in this study improve the comparability of results from prospective and already performed LMM GWAS on complex diseases by providing a reliable transformation to a common comparative scale for the genetic effects.","lang":"eng"}],"publication_identifier":{"issn":["0016-6731","1943-2631"]},"citation":{"mla":"Lloyd-Jones, Luke R., et al. “Transformation of Summary Statistics from Linear Mixed Model Association on All-or-None Traits to Odds Ratio.” <i>Genetics</i>, vol. 208, no. 4, Genetics Society of America, 2018, pp. 1397–408, doi:<a href=\"https://doi.org/10.1534/genetics.117.300360\">10.1534/genetics.117.300360</a>.","apa":"Lloyd-Jones, L. R., Robinson, M. R., Yang, J., &#38; Visscher, P. M. (2018). Transformation of summary statistics from linear mixed model association on all-or-none traits to odds ratio. <i>Genetics</i>. Genetics Society of America. <a href=\"https://doi.org/10.1534/genetics.117.300360\">https://doi.org/10.1534/genetics.117.300360</a>","chicago":"Lloyd-Jones, Luke R., Matthew Richard Robinson, Jian Yang, and Peter M. Visscher. “Transformation of Summary Statistics from Linear Mixed Model Association on All-or-None Traits to Odds Ratio.” <i>Genetics</i>. Genetics Society of America, 2018. <a href=\"https://doi.org/10.1534/genetics.117.300360\">https://doi.org/10.1534/genetics.117.300360</a>.","short":"L.R. Lloyd-Jones, M.R. Robinson, J. Yang, P.M. Visscher, Genetics 208 (2018) 1397–1408.","ieee":"L. R. Lloyd-Jones, M. R. Robinson, J. Yang, and P. M. Visscher, “Transformation of summary statistics from linear mixed model association on all-or-none traits to odds ratio,” <i>Genetics</i>, vol. 208, no. 4. Genetics Society of America, pp. 1397–1408, 2018.","ista":"Lloyd-Jones LR, Robinson MR, Yang J, Visscher PM. 2018. Transformation of summary statistics from linear mixed model association on all-or-none traits to odds ratio. Genetics. 208(4), 1397–1408.","ama":"Lloyd-Jones LR, Robinson MR, Yang J, Visscher PM. Transformation of summary statistics from linear mixed model association on all-or-none traits to odds ratio. <i>Genetics</i>. 2018;208(4):1397-1408. doi:<a href=\"https://doi.org/10.1534/genetics.117.300360\">10.1534/genetics.117.300360</a>"},"extern":"1","volume":208,"quality_controlled":"1","day":"01","status":"public","_id":"7723","date_created":"2020-04-30T10:45:19Z"},{"_id":"7724","date_created":"2020-04-30T10:45:43Z","quality_controlled":"1","day":"02","status":"public","volume":115,"citation":{"ama":"Sanjak JS, Sidorenko J, Robinson MR, Thornton KR, Visscher PM. Evidence of directional and stabilizing selection in contemporary humans. <i>Proceedings of the National Academy of Sciences</i>. 2018;115(1):151-156. doi:<a href=\"https://doi.org/10.1073/pnas.1707227114\">10.1073/pnas.1707227114</a>","ieee":"J. S. Sanjak, J. Sidorenko, M. R. Robinson, K. R. Thornton, and P. M. Visscher, “Evidence of directional and stabilizing selection in contemporary humans,” <i>Proceedings of the National Academy of Sciences</i>, vol. 115, no. 1. Proceedings of the National Academy of Sciences, pp. 151–156, 2018.","short":"J.S. Sanjak, J. Sidorenko, M.R. Robinson, K.R. Thornton, P.M. Visscher, Proceedings of the National Academy of Sciences 115 (2018) 151–156.","ista":"Sanjak JS, Sidorenko J, Robinson MR, Thornton KR, Visscher PM. 2018. Evidence of directional and stabilizing selection in contemporary humans. Proceedings of the National Academy of Sciences. 115(1), 151–156.","chicago":"Sanjak, Jaleal S., Julia Sidorenko, Matthew Richard Robinson, Kevin R. Thornton, and Peter M. Visscher. “Evidence of Directional and Stabilizing Selection in Contemporary Humans.” <i>Proceedings of the National Academy of Sciences</i>. Proceedings of the National Academy of Sciences, 2018. <a href=\"https://doi.org/10.1073/pnas.1707227114\">https://doi.org/10.1073/pnas.1707227114</a>.","apa":"Sanjak, J. S., Sidorenko, J., Robinson, M. R., Thornton, K. R., &#38; Visscher, P. M. (2018). Evidence of directional and stabilizing selection in contemporary humans. <i>Proceedings of the National Academy of Sciences</i>. Proceedings of the National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.1707227114\">https://doi.org/10.1073/pnas.1707227114</a>","mla":"Sanjak, Jaleal S., et al. “Evidence of Directional and Stabilizing Selection in Contemporary Humans.” <i>Proceedings of the National Academy of Sciences</i>, vol. 115, no. 1, Proceedings of the National Academy of Sciences, 2018, pp. 151–56, doi:<a href=\"https://doi.org/10.1073/pnas.1707227114\">10.1073/pnas.1707227114</a>."},"extern":"1","publication_identifier":{"issn":["0027-8424","1091-6490"]},"abstract":[{"lang":"eng","text":"Modern molecular genetic datasets, primarily collected to study the biology of human health and disease, can be used to directly measure the action of natural selection and reveal important features of contemporary human evolution. Here we leverage the UK Biobank data to test for the presence of linear and nonlinear natural selection in a contemporary population of the United Kingdom. We obtain phenotypic and genetic evidence consistent with the action of linear/directional selection. Phenotypic evidence suggests that stabilizing selection, which acts to reduce variance in the population without necessarily modifying the population mean, is widespread and relatively weak in comparison with estimates from other species."}],"type":"journal_article","related_material":{"link":[{"url":"https://doi.org/10.1073/pnas.1806837115","relation":"erratum"}]},"oa_version":"None","publication":"Proceedings of the National Academy of Sciences","doi":"10.1073/pnas.1707227114","publication_status":"published","date_updated":"2021-01-12T08:15:07Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Evidence of directional and stabilizing selection in contemporary humans","author":[{"full_name":"Sanjak, Jaleal S.","last_name":"Sanjak","first_name":"Jaleal S."},{"last_name":"Sidorenko","first_name":"Julia","full_name":"Sidorenko, Julia"},{"full_name":"Robinson, Matthew Richard","last_name":"Robinson","orcid":"0000-0001-8982-8813","first_name":"Matthew Richard","id":"E5D42276-F5DA-11E9-8E24-6303E6697425"},{"first_name":"Kevin R.","last_name":"Thornton","full_name":"Thornton, Kevin R."},{"full_name":"Visscher, Peter M.","first_name":"Peter M.","last_name":"Visscher"}],"issue":"1","date_published":"2018-01-02T00:00:00Z","intvolume":"       115","month":"01","publisher":"Proceedings of the National Academy of Sciences","language":[{"iso":"eng"}],"article_type":"original","year":"2018","article_processing_charge":"No","page":"151-156"},{"oa_version":"Published Version","publication":"Nature Communications","publication_status":"published","doi":"10.1038/s41467-018-06851-5","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1038/s41467-018-06851-5"}],"status":"public","quality_controlled":"1","day":"19","_id":"7754","date_created":"2020-04-30T11:38:01Z","abstract":[{"text":"Creating a selective gel that filters particles based on their interactions is a major goal of nanotechnology, with far-reaching implications from drug delivery to controlling assembly pathways. However, this is particularly difficult when the particles are larger than the gel’s characteristic mesh size because such particles cannot passively pass through the gel. Thus, filtering requires the interacting particles to transiently reorganize the gel’s internal structure. While significant advances, e.g., in DNA engineering, have enabled the design of nano-materials with programmable interactions, it is not clear what physical principles such a designer gel could exploit to achieve selective permeability. We present an equilibrium mechanism where crosslink binding dynamics are affected by interacting particles such that particle diffusion is enhanced. In addition to revealing specific design rules for manufacturing selective gels, our results have the potential to explain the origin of selective permeability in certain biological materials, including the nuclear pore complex.","lang":"eng"}],"type":"journal_article","volume":9,"extern":"1","publication_identifier":{"issn":["2041-1723"]},"citation":{"mla":"Goodrich, Carl Peter, et al. “Enhanced Diffusion by Binding to the Crosslinks of a Polymer Gel.” <i>Nature Communications</i>, vol. 9, 4348, Springer Nature, 2018, doi:<a href=\"https://doi.org/10.1038/s41467-018-06851-5\">10.1038/s41467-018-06851-5</a>.","apa":"Goodrich, C. P., Brenner, M. P., &#38; Ribbeck, K. (2018). Enhanced diffusion by binding to the crosslinks of a polymer gel. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-018-06851-5\">https://doi.org/10.1038/s41467-018-06851-5</a>","chicago":"Goodrich, Carl Peter, Michael P. Brenner, and Katharina Ribbeck. “Enhanced Diffusion by Binding to the Crosslinks of a Polymer Gel.” <i>Nature Communications</i>. Springer Nature, 2018. <a href=\"https://doi.org/10.1038/s41467-018-06851-5\">https://doi.org/10.1038/s41467-018-06851-5</a>.","short":"C.P. Goodrich, M.P. Brenner, K. Ribbeck, Nature Communications 9 (2018).","ista":"Goodrich CP, Brenner MP, Ribbeck K. 2018. Enhanced diffusion by binding to the crosslinks of a polymer gel. Nature Communications. 9, 4348.","ieee":"C. P. Goodrich, M. P. Brenner, and K. Ribbeck, “Enhanced diffusion by binding to the crosslinks of a polymer gel,” <i>Nature Communications</i>, vol. 9. Springer Nature, 2018.","ama":"Goodrich CP, Brenner MP, Ribbeck K. Enhanced diffusion by binding to the crosslinks of a polymer gel. <i>Nature Communications</i>. 2018;9. doi:<a href=\"https://doi.org/10.1038/s41467-018-06851-5\">10.1038/s41467-018-06851-5</a>"},"article_type":"original","year":"2018","language":[{"iso":"eng"}],"article_processing_charge":"No","author":[{"last_name":"Goodrich","orcid":"0000-0002-1307-5074","id":"EB352CD2-F68A-11E9-89C5-A432E6697425","first_name":"Carl Peter","full_name":"Goodrich, Carl Peter"},{"full_name":"Brenner, Michael P.","last_name":"Brenner","first_name":"Michael P."},{"full_name":"Ribbeck, Katharina","first_name":"Katharina","last_name":"Ribbeck"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Enhanced diffusion by binding to the crosslinks of a polymer gel","oa":1,"date_updated":"2021-01-12T08:15:18Z","publisher":"Springer Nature","article_number":"4348","date_published":"2018-10-19T00:00:00Z","month":"10","intvolume":"         9"},{"publication_status":"published","doi":"10.1126/scitranslmed.aar7514","publication":"Science Translational Medicine","oa_version":"None","type":"journal_article","abstract":[{"lang":"eng","text":"Inhibition of the endoplasmic reticulum stress pathway may hold the key to Zika virus-associated microcephaly treatment. "}],"scopus_import":1,"citation":{"apa":"Novarino, G. (2018). Zika-associated microcephaly: Reduce the stress and race for the treatment. <i>Science Translational Medicine</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/scitranslmed.aar7514\">https://doi.org/10.1126/scitranslmed.aar7514</a>","mla":"Novarino, Gaia. “Zika-Associated Microcephaly: Reduce the Stress and Race for the Treatment.” <i>Science Translational Medicine</i>, vol. 10, no. 423, eaar7514, American Association for the Advancement of Science, 2018, doi:<a href=\"https://doi.org/10.1126/scitranslmed.aar7514\">10.1126/scitranslmed.aar7514</a>.","ieee":"G. Novarino, “Zika-associated microcephaly: Reduce the stress and race for the treatment,” <i>Science Translational Medicine</i>, vol. 10, no. 423. American Association for the Advancement of Science, 2018.","short":"G. Novarino, Science Translational Medicine 10 (2018).","ista":"Novarino G. 2018. Zika-associated microcephaly: Reduce the stress and race for the treatment. Science Translational Medicine. 10(423), eaar7514.","ama":"Novarino G. Zika-associated microcephaly: Reduce the stress and race for the treatment. <i>Science Translational Medicine</i>. 2018;10(423). doi:<a href=\"https://doi.org/10.1126/scitranslmed.aar7514\">10.1126/scitranslmed.aar7514</a>","chicago":"Novarino, Gaia. “Zika-Associated Microcephaly: Reduce the Stress and Race for the Treatment.” <i>Science Translational Medicine</i>. American Association for the Advancement of Science, 2018. <a href=\"https://doi.org/10.1126/scitranslmed.aar7514\">https://doi.org/10.1126/scitranslmed.aar7514</a>."},"volume":10,"quality_controlled":"1","status":"public","day":"10","date_created":"2018-12-11T11:46:34Z","_id":"456","department":[{"_id":"GaNo"}],"publist_id":"7365","year":"2018","language":[{"iso":"eng"}],"publisher":"American Association for the Advancement of Science","article_number":"eaar7514","month":"01","intvolume":"        10","date_published":"2018-01-10T00:00:00Z","issue":"423","user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","title":"Zika-associated microcephaly: Reduce the stress and race for the treatment","author":[{"first_name":"Gaia","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","last_name":"Novarino","orcid":"0000-0002-7673-7178","full_name":"Novarino, Gaia"}],"date_updated":"2021-01-12T07:59:42Z"},{"publication":"Nature Ecology and Evolution","doi":"10.1038/s41559-017-0424-z","oa_version":"None","ec_funded":1,"isi":1,"related_material":{"record":[{"id":"202","relation":"dissertation_contains","status":"public"}]},"volume":2,"day":"01","status":"public","date_created":"2018-12-11T11:46:35Z","page":"359 - 366","external_id":{"isi":["000426516400027"]},"year":"2018","date_published":"2018-02-01T00:00:00Z","month":"02","intvolume":"         2","issue":"2","date_updated":"2023-09-15T12:04:57Z","publication_status":"published","project":[{"grant_number":"291734","call_identifier":"FP7","name":"International IST Postdoc Fellowship Programme","_id":"25681D80-B435-11E9-9278-68D0E5697425"},{"name":"Multi-Level Conflicts in Evolutionary Dynamics of Restriction-Modification Systems (HFSP Young investigators' grant)","_id":"251BCBEC-B435-11E9-9278-68D0E5697425","grant_number":"RGY0079/2011"},{"grant_number":"24210","_id":"251D65D8-B435-11E9-9278-68D0E5697425","name":"Effects of Stochasticity on the Function of Restriction-Modi cation Systems at the Single-Cell Level (DOC Fellowship)"}],"abstract":[{"lang":"eng","text":"Temperate bacteriophages integrate in bacterial genomes as prophages and represent an important source of genetic variation for bacterial evolution, frequently transmitting fitness-augmenting genes such as toxins responsible for virulence of major pathogens. However, only a fraction of bacteriophage infections are lysogenic and lead to prophage acquisition, whereas the majority are lytic and kill the infected bacteria. Unless able to discriminate lytic from lysogenic infections, mechanisms of immunity to bacteriophages are expected to act as a double-edged sword and increase the odds of survival at the cost of depriving bacteria of potentially beneficial prophages. We show that although restriction-modification systems as mechanisms of innate immunity prevent both lytic and lysogenic infections indiscriminately in individual bacteria, they increase the number of prophage-acquiring individuals at the population level. We find that this counterintuitive result is a consequence of phage-host population dynamics, in which restriction-modification systems delay infection onset until bacteria reach densities at which the probability of lysogeny increases. These results underscore the importance of population-level dynamics as a key factor modulating costs and benefits of immunity to temperate bacteriophages"}],"scopus_import":"1","type":"journal_article","citation":{"mla":"Pleska, Maros, et al. “Phage-Host Population Dynamics Promotes Prophage Acquisition in Bacteria with Innate Immunity.” <i>Nature Ecology and Evolution</i>, vol. 2, no. 2, Springer Nature, 2018, pp. 359–66, doi:<a href=\"https://doi.org/10.1038/s41559-017-0424-z\">10.1038/s41559-017-0424-z</a>.","apa":"Pleska, M., Lang, M., Refardt, D., Levin, B., &#38; Guet, C. C. (2018). Phage-host population dynamics promotes prophage acquisition in bacteria with innate immunity. <i>Nature Ecology and Evolution</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41559-017-0424-z\">https://doi.org/10.1038/s41559-017-0424-z</a>","chicago":"Pleska, Maros, Moritz Lang, Dominik Refardt, Bruce Levin, and Calin C Guet. “Phage-Host Population Dynamics Promotes Prophage Acquisition in Bacteria with Innate Immunity.” <i>Nature Ecology and Evolution</i>. Springer Nature, 2018. <a href=\"https://doi.org/10.1038/s41559-017-0424-z\">https://doi.org/10.1038/s41559-017-0424-z</a>.","ama":"Pleska M, Lang M, Refardt D, Levin B, Guet CC. Phage-host population dynamics promotes prophage acquisition in bacteria with innate immunity. <i>Nature Ecology and Evolution</i>. 2018;2(2):359-366. doi:<a href=\"https://doi.org/10.1038/s41559-017-0424-z\">10.1038/s41559-017-0424-z</a>","ieee":"M. Pleska, M. Lang, D. Refardt, B. Levin, and C. C. Guet, “Phage-host population dynamics promotes prophage acquisition in bacteria with innate immunity,” <i>Nature Ecology and Evolution</i>, vol. 2, no. 2. Springer Nature, pp. 359–366, 2018.","short":"M. Pleska, M. Lang, D. Refardt, B. Levin, C.C. Guet, Nature Ecology and Evolution 2 (2018) 359–366.","ista":"Pleska M, Lang M, Refardt D, Levin B, Guet CC. 2018. Phage-host population dynamics promotes prophage acquisition in bacteria with innate immunity. Nature Ecology and Evolution. 2(2), 359–366."},"quality_controlled":"1","_id":"457","publist_id":"7364","department":[{"_id":"CaGu"},{"_id":"GaTk"}],"article_processing_charge":"No","language":[{"iso":"eng"}],"publisher":"Springer Nature","title":"Phage-host population dynamics promotes prophage acquisition in bacteria with innate immunity","author":[{"id":"4569785E-F248-11E8-B48F-1D18A9856A87","first_name":"Maros","orcid":"0000-0001-7460-7479","last_name":"Pleska","full_name":"Pleska, Maros"},{"last_name":"Lang","id":"29E0800A-F248-11E8-B48F-1D18A9856A87","first_name":"Moritz","full_name":"Lang, Moritz"},{"full_name":"Refardt, Dominik","first_name":"Dominik","last_name":"Refardt"},{"full_name":"Levin, Bruce","first_name":"Bruce","last_name":"Levin"},{"full_name":"Guet, Calin C","first_name":"Calin C","id":"47F8433E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6220-2052","last_name":"Guet"}],"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1"},{"date_updated":"2023-09-11T14:19:12Z","oa":1,"issue":"4","date_published":"2018-04-01T00:00:00Z","month":"04","intvolume":"       370","acknowledgement":"DFG Collaborative Research Center TRR 109 “Discretization in Geometry and Dynamics”; People Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme (FP7/2007-2013) REA grant agreement n◦[291734]","year":"2018","page":"2825 - 2854","external_id":{"isi":["000423197800019"]},"date_created":"2018-12-11T11:46:35Z","status":"public","day":"01","volume":370,"oa_version":"Preprint","ec_funded":1,"isi":1,"publication":"Transactions of the American Mathematical Society","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1602.04637"}],"doi":"10.1090/tran/7292","author":[{"full_name":"Akopyan, Arseniy","id":"430D2C90-F248-11E8-B48F-1D18A9856A87","first_name":"Arseniy","orcid":"0000-0002-2548-617X","last_name":"Akopyan"},{"full_name":"Bobenko, Alexander","first_name":"Alexander","last_name":"Bobenko"}],"title":"Incircular nets and confocal conics","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","publisher":"American Mathematical Society","language":[{"iso":"eng"}],"article_processing_charge":"No","department":[{"_id":"HeEd"}],"publist_id":"7363","_id":"458","quality_controlled":"1","citation":{"mla":"Akopyan, Arseniy, and Alexander Bobenko. “Incircular Nets and Confocal Conics.” <i>Transactions of the American Mathematical Society</i>, vol. 370, no. 4, American Mathematical Society, 2018, pp. 2825–54, doi:<a href=\"https://doi.org/10.1090/tran/7292\">10.1090/tran/7292</a>.","apa":"Akopyan, A., &#38; Bobenko, A. (2018). Incircular nets and confocal conics. <i>Transactions of the American Mathematical Society</i>. American Mathematical Society. <a href=\"https://doi.org/10.1090/tran/7292\">https://doi.org/10.1090/tran/7292</a>","chicago":"Akopyan, Arseniy, and Alexander Bobenko. “Incircular Nets and Confocal Conics.” <i>Transactions of the American Mathematical Society</i>. American Mathematical Society, 2018. <a href=\"https://doi.org/10.1090/tran/7292\">https://doi.org/10.1090/tran/7292</a>.","ama":"Akopyan A, Bobenko A. Incircular nets and confocal conics. <i>Transactions of the American Mathematical Society</i>. 2018;370(4):2825-2854. doi:<a href=\"https://doi.org/10.1090/tran/7292\">10.1090/tran/7292</a>","short":"A. Akopyan, A. Bobenko, Transactions of the American Mathematical Society 370 (2018) 2825–2854.","ieee":"A. Akopyan and A. Bobenko, “Incircular nets and confocal conics,” <i>Transactions of the American Mathematical Society</i>, vol. 370, no. 4. American Mathematical Society, pp. 2825–2854, 2018.","ista":"Akopyan A, Bobenko A. 2018. Incircular nets and confocal conics. Transactions of the American Mathematical Society. 370(4), 2825–2854."},"abstract":[{"text":"We consider congruences of straight lines in a plane with the combinatorics of the square grid, with all elementary quadrilaterals possessing an incircle. It is shown that all the vertices of such nets (we call them incircular or IC-nets) lie on confocal conics. Our main new results are on checkerboard IC-nets in the plane. These are congruences of straight lines in the plane with the combinatorics of the square grid, combinatorially colored as a checkerboard, such that all black coordinate quadrilaterals possess inscribed circles. We show how this larger class of IC-nets appears quite naturally in Laguerre geometry of oriented planes and spheres and leads to new remarkable incidence theorems. Most of our results are valid in hyperbolic and spherical geometries as well. We present also generalizations in spaces of higher dimension, called checkerboard IS-nets. The construction of these nets is based on a new 9 inspheres incidence theorem.","lang":"eng"}],"scopus_import":"1","type":"journal_article","project":[{"name":"International IST Postdoc Fellowship Programme","_id":"25681D80-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","grant_number":"291734"}],"publication_status":"published"},{"publication":"Physical Review B","main_file_link":[{"url":"https://arxiv.org/abs/1806.08316","open_access":"1"}],"doi":"10.1103/PhysRevB.98.161122","oa_version":"Preprint","isi":1,"volume":98,"day":"15","status":"public","date_created":"2018-12-11T11:44:20Z","external_id":{"isi":["000448596500002"],"arxiv":["1806.08316"]},"year":"2018","acknowledgement":"F.P. acknowledges the sup- port of the DFG Research Unit FOR 1807 through Grants No. PO 1370/2-1 and No. TRR80, the Nanosystems Initiative Munich (NIM) by the German Excellence Initiative, and the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant Agreement No. 771537). N.Y.Y. acknowledges support from the NSF (PHY-1654740), the ARO STIR program, and a Google research award.","article_number":"161122","date_published":"2018-10-15T00:00:00Z","month":"10","intvolume":"        98","oa":1,"issue":"16","date_updated":"2023-09-11T12:55:03Z","publication_status":"published","arxiv":1,"scopus_import":"1","abstract":[{"text":"We analyze a disordered central spin model, where a central spin interacts equally with each spin in a periodic one-dimensional (1D) random-field Heisenberg chain. If the Heisenberg chain is initially in the many-body localized (MBL) phase, we find that the coupling to the central spin suffices to delocalize the chain for a substantial range of coupling strengths. We calculate the phase diagram of the model and identify the phase boundary between the MBL and ergodic phase. Within the localized phase, the central spin significantly enhances the rate of the logarithmic entanglement growth and its saturation value. We attribute the increase in entanglement entropy to a nonextensive enhancement of magnetization fluctuations induced by the central spin. Finally, we demonstrate that correlation functions of the central spin can be utilized to distinguish between MBL and ergodic phases of the 1D chain. Hence, we propose the use of a central spin as a possible experimental probe to identify the MBL phase.","lang":"eng"}],"type":"journal_article","citation":{"ama":"Hetterich D, Yao N, Serbyn M, Pollmann F, Trauzettel B. Detection and characterization of many-body localization in central spin models. <i>Physical Review B</i>. 2018;98(16). doi:<a href=\"https://doi.org/10.1103/PhysRevB.98.161122\">10.1103/PhysRevB.98.161122</a>","ieee":"D. Hetterich, N. Yao, M. Serbyn, F. Pollmann, and B. Trauzettel, “Detection and characterization of many-body localization in central spin models,” <i>Physical Review B</i>, vol. 98, no. 16. American Physical Society, 2018.","short":"D. Hetterich, N. Yao, M. Serbyn, F. Pollmann, B. Trauzettel, Physical Review B 98 (2018).","ista":"Hetterich D, Yao N, Serbyn M, Pollmann F, Trauzettel B. 2018. Detection and characterization of many-body localization in central spin models. Physical Review B. 98(16), 161122.","chicago":"Hetterich, Daniel, Norman Yao, Maksym Serbyn, Frank Pollmann, and Björn Trauzettel. “Detection and Characterization of Many-Body Localization in Central Spin Models.” <i>Physical Review B</i>. American Physical Society, 2018. <a href=\"https://doi.org/10.1103/PhysRevB.98.161122\">https://doi.org/10.1103/PhysRevB.98.161122</a>.","apa":"Hetterich, D., Yao, N., Serbyn, M., Pollmann, F., &#38; Trauzettel, B. (2018). Detection and characterization of many-body localization in central spin models. <i>Physical Review B</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevB.98.161122\">https://doi.org/10.1103/PhysRevB.98.161122</a>","mla":"Hetterich, Daniel, et al. “Detection and Characterization of Many-Body Localization in Central Spin Models.” <i>Physical Review B</i>, vol. 98, no. 16, 161122, American Physical Society, 2018, doi:<a href=\"https://doi.org/10.1103/PhysRevB.98.161122\">10.1103/PhysRevB.98.161122</a>."},"quality_controlled":"1","_id":"46","publist_id":"8008","department":[{"_id":"MaSe"}],"article_processing_charge":"No","article_type":"original","language":[{"iso":"eng"}],"publisher":"American Physical Society","title":"Detection and characterization of many-body localization in central spin models","author":[{"full_name":"Hetterich, Daniel","first_name":"Daniel","last_name":"Hetterich"},{"last_name":"Yao","first_name":"Norman","full_name":"Yao, Norman"},{"full_name":"Serbyn, Maksym","orcid":"0000-0002-2399-5827","last_name":"Serbyn","id":"47809E7E-F248-11E8-B48F-1D18A9856A87","first_name":"Maksym"},{"full_name":"Pollmann, Frank","first_name":"Frank","last_name":"Pollmann"},{"first_name":"Björn","last_name":"Trauzettel","full_name":"Trauzettel, Björn"}],"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1"},{"type":"journal_article","abstract":[{"text":"Turbulence is the major cause of friction losses in transport processes and it is responsible for a drastic drag increase in flows over bounding surfaces. While much effort is invested into developing ways to control and reduce turbulence intensities, so far no methods exist to altogether eliminate turbulence if velocities are sufficiently large. We demonstrate for pipe flow that appropriate distortions to the velocity profile lead to a complete collapse of turbulence and subsequently friction losses are reduced by as much as 90%. Counterintuitively, the return to laminar motion is accomplished by initially increasing turbulence intensities or by transiently amplifying wall shear. Since neither the Reynolds number nor the shear stresses decrease (the latter often increase), these measures are not indicative of turbulence collapse. Instead, an amplification mechanism                      measuring the interaction between eddies and the mean shear is found to set a threshold below which turbulence is suppressed beyond recovery.","lang":"eng"}],"scopus_import":"1","citation":{"mla":"Kühnen, Jakob, et al. “Destabilizing Turbulence in Pipe Flow.” <i>Nature Physics</i>, vol. 14, Nature Publishing Group, 2018, pp. 386–90, doi:<a href=\"https://doi.org/10.1038/s41567-017-0018-3\">10.1038/s41567-017-0018-3</a>.","apa":"Kühnen, J., Song, B., Scarselli, D., Budanur, N. B., Riedl, M., Willis, A., … Hof, B. (2018). Destabilizing turbulence in pipe flow. <i>Nature Physics</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/s41567-017-0018-3\">https://doi.org/10.1038/s41567-017-0018-3</a>","chicago":"Kühnen, Jakob, Baofang Song, Davide Scarselli, Nazmi B Budanur, Michael Riedl, Ashley Willis, Marc Avila, and Björn Hof. “Destabilizing Turbulence in Pipe Flow.” <i>Nature Physics</i>. Nature Publishing Group, 2018. <a href=\"https://doi.org/10.1038/s41567-017-0018-3\">https://doi.org/10.1038/s41567-017-0018-3</a>.","ama":"Kühnen J, Song B, Scarselli D, et al. Destabilizing turbulence in pipe flow. <i>Nature Physics</i>. 2018;14:386-390. doi:<a href=\"https://doi.org/10.1038/s41567-017-0018-3\">10.1038/s41567-017-0018-3</a>","ista":"Kühnen J, Song B, Scarselli D, Budanur NB, Riedl M, Willis A, Avila M, Hof B. 2018. Destabilizing turbulence in pipe flow. Nature Physics. 14, 386–390.","short":"J. Kühnen, B. Song, D. Scarselli, N.B. Budanur, M. Riedl, A. Willis, M. Avila, B. Hof, Nature Physics 14 (2018) 386–390.","ieee":"J. Kühnen <i>et al.</i>, “Destabilizing turbulence in pipe flow,” <i>Nature Physics</i>, vol. 14. Nature Publishing Group, pp. 386–390, 2018."},"quality_controlled":"1","_id":"461","publication_status":"published","project":[{"_id":"25152F3A-B435-11E9-9278-68D0E5697425","name":"Decoding the complexity of turbulence at its origin","call_identifier":"FP7","grant_number":"306589"},{"_id":"25104D44-B435-11E9-9278-68D0E5697425","name":"Eliminating turbulence in oil pipelines","call_identifier":"H2020","grant_number":"737549"}],"publisher":"Nature Publishing Group","title":"Destabilizing turbulence in pipe flow","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","author":[{"full_name":"Kühnen, Jakob","orcid":"0000-0003-4312-0179","last_name":"Kühnen","id":"3A47AE32-F248-11E8-B48F-1D18A9856A87","first_name":"Jakob"},{"full_name":"Song, Baofang","first_name":"Baofang","last_name":"Song"},{"full_name":"Scarselli, Davide","last_name":"Scarselli","orcid":"0000-0001-5227-4271","id":"40315C30-F248-11E8-B48F-1D18A9856A87","first_name":"Davide"},{"full_name":"Budanur, Nazmi B","orcid":"0000-0003-0423-5010","last_name":"Budanur","id":"3EA1010E-F248-11E8-B48F-1D18A9856A87","first_name":"Nazmi B"},{"id":"3BE60946-F248-11E8-B48F-1D18A9856A87","first_name":"Michael","orcid":"0000-0003-4844-6311","last_name":"Riedl","full_name":"Riedl, Michael"},{"full_name":"Willis, Ashley","last_name":"Willis","first_name":"Ashley"},{"first_name":"Marc","last_name":"Avila","full_name":"Avila, Marc"},{"full_name":"Hof, Björn","orcid":"0000-0003-2057-2754","last_name":"Hof","id":"3A374330-F248-11E8-B48F-1D18A9856A87","first_name":"Björn"}],"department":[{"_id":"BjHo"}],"publist_id":"7360","article_processing_charge":"No","language":[{"iso":"eng"}],"volume":14,"day":"08","status":"public","date_created":"2018-12-11T11:46:36Z","doi":"10.1038/s41567-017-0018-3","main_file_link":[{"url":"https://arxiv.org/abs/1711.06543","open_access":"1"}],"publication":"Nature Physics","isi":1,"ec_funded":1,"oa_version":"Preprint","related_material":{"record":[{"id":"12726","status":"public","relation":"dissertation_contains"},{"id":"14530","status":"public","relation":"dissertation_contains"},{"status":"public","relation":"dissertation_contains","id":"7258"}]},"acknowledgement":"We acknowledge the European Research Council under the European Union’s Seventh Framework Programme (FP/2007-2013)/ERC Grant Agreement 306589, the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement no. 737549) and the Deutsche Forschungsgemeinschaft (Project No. FOR 1182) for financial support. We thank our technician P. Maier for providing highly valuable ideas and greatly supporting us in all technical aspects. We thank M. Schaner for technical drawings, construction and design. We thank M. Schwegel for a Matlab code to post-process experimental data.","month":"01","intvolume":"        14","date_published":"2018-01-08T00:00:00Z","oa":1,"date_updated":"2024-03-25T23:30:20Z","external_id":{"isi":["000429434100020"]},"page":"386-390","year":"2018"},{"acknowledgement":"This work was supported by the National Natural Science Foundation of China (31571464, 31371438 and 31070222 to Q.S.Q.), the National Basic Research Program of China (973 project, 2013CB429904 to Q.S.Q.), the Research Fund for the Doctoral Program of Higher Education of China (20130211110001 to Q.S.Q.), the Ministry of Education, Youth and Sports of the Czech Republic (the National Program for Sustainability I, LO1204), and The Czech Science Foundation GAČR (GA13–40637S) to JF. We thank Dr. Tom J. Guilfoyle for DR5::GUS line and Dr. Jia Li for pBIB‐RFP vector and DR5::GFP line. We thank Liping Guan and Yang Zhao for their help with the confocal microscope assay. ","date_published":"2018-05-01T00:00:00Z","intvolume":"        41","month":"05","oa":1,"date_updated":"2023-09-13T09:03:18Z","external_id":{"isi":["000426870500012"],"pmid":["29360148"]},"page":"850 - 864","year":"2018","volume":41,"pmid":1,"day":"01","status":"public","date_created":"2018-12-11T11:46:36Z","tmp":{"short":"CC BY-NC (4.0)","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","image":"/images/cc_by_nc.png"},"ddc":["580"],"publication":"Plant, Cell and Environment","doi":"10.1111/pce.13153","oa_version":"Submitted Version","isi":1,"publisher":"Wiley-Blackwell","has_accepted_license":"1","title":"NHX antiporters regulate the pH of endoplasmic reticulum and auxin-mediated development","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","author":[{"last_name":"Fan","first_name":"Ligang","full_name":"Fan, Ligang"},{"full_name":"Zhao, Lei","first_name":"Lei","last_name":"Zhao"},{"first_name":"Wei","last_name":"Hu","full_name":"Hu, Wei"},{"last_name":"Li","first_name":"Weina","full_name":"Li, Weina"},{"last_name":"Novák","first_name":"Ondřej","full_name":"Novák, Ondřej"},{"last_name":"Strnad","first_name":"Miroslav","full_name":"Strnad, Miroslav"},{"full_name":"Simon, Sibu","last_name":"Simon","orcid":"0000-0002-1998-6741","id":"4542EF9A-F248-11E8-B48F-1D18A9856A87","first_name":"Sibu"},{"full_name":"Friml, Jirí","id":"4159519E-F248-11E8-B48F-1D18A9856A87","first_name":"Jirí","orcid":"0000-0002-8302-7596","last_name":"Friml"},{"first_name":"Jinbo","last_name":"Shen","full_name":"Shen, Jinbo"},{"first_name":"Liwen","last_name":"Jiang","full_name":"Jiang, Liwen"},{"full_name":"Qiu, Quan","first_name":"Quan","last_name":"Qiu"}],"file":[{"creator":"dernst","file_size":1937976,"file_id":"7042","content_type":"application/pdf","relation":"main_file","checksum":"6a20f843565f962cb20281cdf5e40914","access_level":"open_access","file_name":"2018_PlantCellEnv_Fan.pdf","date_updated":"2020-07-14T12:46:32Z","date_created":"2019-11-18T16:22:22Z"}],"department":[{"_id":"JiFr"}],"publist_id":"7359","article_processing_charge":"No","article_type":"original","language":[{"iso":"eng"}],"scopus_import":"1","abstract":[{"text":"AtNHX5 and AtNHX6 are endosomal Na+,K+/H+ antiporters that are critical for growth and development in Arabidopsis, but the mechanism behind their action remains unknown. Here, we report that AtNHX5 and AtNHX6, functioning as H+ leak, control auxin homeostasis and auxin-mediated development. We found that nhx5 nhx6 exhibited growth variations of auxin-related defects. We further showed that nhx5 nhx6 was affected in auxin homeostasis. Genetic analysis showed that AtNHX5 and AtNHX6 were required for the function of the ER-localized auxin transporter PIN5. Although AtNHX5 and AtNHX6 were co-localized with PIN5 at ER, they did not interact directly. Instead, the conserved acidic residues in AtNHX5 and AtNHX6, which are essential for exchange activity, were required for PIN5 function. AtNHX5 and AtNHX6 regulated the pH in ER. Overall, AtNHX5 and AtNHX6 may regulate auxin transport across the ER via the pH gradient created by their transport activity. H+-leak pathway provides a fine-tuning mechanism that controls cellular auxin fluxes. ","lang":"eng"}],"type":"journal_article","file_date_updated":"2020-07-14T12:46:32Z","citation":{"apa":"Fan, L., Zhao, L., Hu, W., Li, W., Novák, O., Strnad, M., … Qiu, Q. (2018). NHX antiporters regulate the pH of endoplasmic reticulum and auxin-mediated development. <i>Plant, Cell and Environment</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1111/pce.13153\">https://doi.org/10.1111/pce.13153</a>","mla":"Fan, Ligang, et al. “NHX Antiporters Regulate the PH of Endoplasmic Reticulum and Auxin-Mediated Development.” <i>Plant, Cell and Environment</i>, vol. 41, Wiley-Blackwell, 2018, pp. 850–64, doi:<a href=\"https://doi.org/10.1111/pce.13153\">10.1111/pce.13153</a>.","ieee":"L. Fan <i>et al.</i>, “NHX antiporters regulate the pH of endoplasmic reticulum and auxin-mediated development,” <i>Plant, Cell and Environment</i>, vol. 41. Wiley-Blackwell, pp. 850–864, 2018.","short":"L. Fan, L. Zhao, W. Hu, W. Li, O. Novák, M. Strnad, S. Simon, J. Friml, J. Shen, L. Jiang, Q. Qiu, Plant, Cell and Environment 41 (2018) 850–864.","ista":"Fan L, Zhao L, Hu W, Li W, Novák O, Strnad M, Simon S, Friml J, Shen J, Jiang L, Qiu Q. 2018. NHX antiporters regulate the pH of endoplasmic reticulum and auxin-mediated development. Plant, Cell and Environment. 41, 850–864.","ama":"Fan L, Zhao L, Hu W, et al. NHX antiporters regulate the pH of endoplasmic reticulum and auxin-mediated development. <i>Plant, Cell and Environment</i>. 2018;41:850-864. doi:<a href=\"https://doi.org/10.1111/pce.13153\">10.1111/pce.13153</a>","chicago":"Fan, Ligang, Lei Zhao, Wei Hu, Weina Li, Ondřej Novák, Miroslav Strnad, Sibu Simon, et al. “NHX Antiporters Regulate the PH of Endoplasmic Reticulum and Auxin-Mediated Development.” <i>Plant, Cell and Environment</i>. Wiley-Blackwell, 2018. <a href=\"https://doi.org/10.1111/pce.13153\">https://doi.org/10.1111/pce.13153</a>."},"quality_controlled":"1","_id":"462","publication_status":"published"},{"publisher":"Elsevier","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","author":[{"full_name":"Abualia, Rashed","orcid":"0000-0002-9357-9415","last_name":"Abualia","id":"4827E134-F248-11E8-B48F-1D18A9856A87","first_name":"Rashed"},{"full_name":"Benková, Eva","first_name":"Eva","id":"38F4F166-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8510-9739","last_name":"Benková"},{"full_name":"Lacombe, Benoît","last_name":"Lacombe","first_name":"Benoît"}],"title":"Transporters and mechanisms of hormone transport in arabidopsis","department":[{"_id":"EvBe"}],"publist_id":"8007","article_processing_charge":"No","language":[{"iso":"eng"}],"type":"journal_article","abstract":[{"text":"Plant hormones as signalling molecules play an essential role in the control of plant growth and development. Typically, sites of hormonal action are usually distant from the site of biosynthesis thus relying on efficient transport mechanisms. Over the last decades, molecular identification of proteins and protein complexes involved in hormonal transport has started. Advanced screens for genes involved in hormonal transport in combination with transport assays using heterologous systems such as yeast, insect, or tobacco BY2 cells or Xenopus oocytes provided important insights into mechanisms underlying distribution of hormones in plant body and led to identification of principal transporters for each hormone. This review gives a short overview of the mechanisms of hormonal transport and transporters identified in Arabidopsis thaliana.","lang":"eng"}],"scopus_import":"1","citation":{"ama":"Abualia R, Benková E, Lacombe B. Transporters and mechanisms of hormone transport in arabidopsis. <i>Advances in Botanical Research</i>. 2018;87:115-138. doi:<a href=\"https://doi.org/10.1016/bs.abr.2018.09.007\">10.1016/bs.abr.2018.09.007</a>","short":"R. Abualia, E. Benková, B. Lacombe, Advances in Botanical Research 87 (2018) 115–138.","ieee":"R. Abualia, E. Benková, and B. Lacombe, “Transporters and mechanisms of hormone transport in arabidopsis,” <i>Advances in Botanical Research</i>, vol. 87. Elsevier, pp. 115–138, 2018.","ista":"Abualia R, Benková E, Lacombe B. 2018. Transporters and mechanisms of hormone transport in arabidopsis. Advances in Botanical Research. 87, 115–138.","chicago":"Abualia, Rashed, Eva Benková, and Benoît Lacombe. “Transporters and Mechanisms of Hormone Transport in Arabidopsis.” <i>Advances in Botanical Research</i>. Elsevier, 2018. <a href=\"https://doi.org/10.1016/bs.abr.2018.09.007\">https://doi.org/10.1016/bs.abr.2018.09.007</a>.","apa":"Abualia, R., Benková, E., &#38; Lacombe, B. (2018). Transporters and mechanisms of hormone transport in arabidopsis. <i>Advances in Botanical Research</i>. Elsevier. <a href=\"https://doi.org/10.1016/bs.abr.2018.09.007\">https://doi.org/10.1016/bs.abr.2018.09.007</a>","mla":"Abualia, Rashed, et al. “Transporters and Mechanisms of Hormone Transport in Arabidopsis.” <i>Advances in Botanical Research</i>, vol. 87, Elsevier, 2018, pp. 115–38, doi:<a href=\"https://doi.org/10.1016/bs.abr.2018.09.007\">10.1016/bs.abr.2018.09.007</a>."},"quality_controlled":"1","_id":"47","publication_status":"published","month":"01","intvolume":"        87","date_published":"2018-01-01T00:00:00Z","date_updated":"2024-03-25T23:30:22Z","page":"115 - 138","external_id":{"isi":["000453657800006"]},"year":"2018","volume":87,"status":"public","day":"01","date_created":"2018-12-11T11:44:20Z","doi":"10.1016/bs.abr.2018.09.007","publication":"Advances in Botanical Research","isi":1,"oa_version":"None","related_material":{"record":[{"status":"public","relation":"dissertation_contains","id":"10303"}]}},{"day":"27","status":"public","supervisor":[{"first_name":"Jozsef L","id":"3FA14672-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-5193-4036","last_name":"Csicsvari","full_name":"Csicsvari, Jozsef L"}],"ddc":["573"],"tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"date_created":"2018-12-11T11:44:21Z","doi":"10.15479/AT:ISTA:th_1042","degree_awarded":"PhD","oa_version":"Published Version","date_published":"2018-08-27T00:00:00Z","alternative_title":["ISTA Thesis"],"month":"08","oa":1,"date_updated":"2023-09-07T12:42:44Z","page":"104","year":"2018","abstract":[{"text":"The hippocampus is a key brain region for spatial memory and navigation and is needed at all stages of memory, including encoding, consolidation, and recall. Hippocampal place cells selectively discharge at specific locations of the environment to form a cognitive map of the space. During the rest period and sleep following spatial navigation and/or learning, the waking activity of the place cells is reactivated within high synchrony events. This reactivation is thought to be important for memory consolidation and stabilization of the spatial representations. The aim of my thesis was to directly test whether the reactivation content encoded in firing patterns of place cells is important for consolidation of spatial memories. In particular, I aimed to test whether, in cases when multiple spatial memory traces are acquired during learning, the specific disruption of the reactivation of a subset of these memories leads to the selective disruption of the corresponding memory traces or through memory interference the other learned memories are disrupted as well. In this thesis, using a modified cheeseboard paradigm and a closed-loop recording setup with feedback optogenetic stimulation, I examined how the disruption of the reactivation of specific spiking patterns affects consolidation of the corresponding memory traces. To obtain multiple distinctive memories, animals had to perform a spatial task in two distinct cheeseboard environments and the reactivation of spiking patterns associated with one of the environments (target) was disrupted after learning during four hours rest period using a real-time decoding method. This real-time decoding method was capable of selectively affecting the firing rates and cofiring correlations of the target environment-encoding cells. The selective disruption led to behavioural impairment in the memory tests after the rest periods in the target environment but not in the other undisrupted control environment. In addition, the map of the target environment was less stable in the impaired memory tests compared to the learning session before than the map of the control environment. However, when the animal relearned the task, the same map recurred in the target environment that was present during learning before the disruption. Altogether my work demonstrated that the reactivation content is important: assembly-related disruption of reactivation can lead to a selective memory impairment and deficiency in map stability. These findings indeed suggest that reactivated assembly patterns reflect processes associated with the consolidation of memory traces. ","lang":"eng"}],"file_date_updated":"2021-02-11T23:30:22Z","type":"dissertation","citation":{"chicago":"Gridchyn, Igor. “Reactivation Content Is Important for Consolidation of Spatial Memory.” Institute of Science and Technology Austria, 2018. <a href=\"https://doi.org/10.15479/AT:ISTA:th_1042\">https://doi.org/10.15479/AT:ISTA:th_1042</a>.","ama":"Gridchyn I. Reactivation content is important for consolidation of spatial memory. 2018. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:th_1042\">10.15479/AT:ISTA:th_1042</a>","short":"I. Gridchyn, Reactivation Content Is Important for Consolidation of Spatial Memory, Institute of Science and Technology Austria, 2018.","ista":"Gridchyn I. 2018. Reactivation content is important for consolidation of spatial memory. Institute of Science and Technology Austria.","ieee":"I. Gridchyn, “Reactivation content is important for consolidation of spatial memory,” Institute of Science and Technology Austria, 2018.","mla":"Gridchyn, Igor. <i>Reactivation Content Is Important for Consolidation of Spatial Memory</i>. Institute of Science and Technology Austria, 2018, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:th_1042\">10.15479/AT:ISTA:th_1042</a>.","apa":"Gridchyn, I. (2018). <i>Reactivation content is important for consolidation of spatial memory</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:th_1042\">https://doi.org/10.15479/AT:ISTA:th_1042</a>"},"publication_identifier":{"issn":["2663-337X"]},"_id":"48","publication_status":"published","publisher":"Institute of Science and Technology Austria","has_accepted_license":"1","author":[{"full_name":"Gridchyn, Igor","id":"4B60654C-F248-11E8-B48F-1D18A9856A87","first_name":"Igor","last_name":"Gridchyn","orcid":"0000-0002-1807-1929"}],"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","title":"Reactivation content is important for consolidation of spatial memory","file":[{"checksum":"7db4415e435590fa33542c7b0a0321d7","relation":"source_file","access_level":"closed","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","file_id":"6236","embargo_to":"open_access","creator":"dernst","file_size":7666687,"date_updated":"2021-02-11T23:30:22Z","date_created":"2019-04-08T13:36:01Z","file_name":"2018_Thesis_Gridchyn_source.docx"},{"access_level":"open_access","relation":"main_file","checksum":"f96f3fe8979f7b1e6db6acaca962b10c","embargo":"2019-08-29","creator":"dernst","file_size":6034153,"file_id":"6237","content_type":"application/pdf","date_updated":"2021-02-11T11:17:18Z","date_created":"2019-04-08T13:36:01Z","file_name":"2018_Thesis_Gridchyn.pdf"}],"publist_id":"8006","department":[{"_id":"JoCs"}],"article_processing_charge":"No","pubrep_id":"1042","language":[{"iso":"eng"}]},{"year":"2018","page":"77","date_updated":"2023-09-07T12:27:43Z","oa":1,"month":"07","date_published":"2018-07-30T00:00:00Z","alternative_title":["ISTA Thesis"],"oa_version":"Published Version","degree_awarded":"PhD","doi":"10.15479/AT:ISTA:th_1033","ddc":["530"],"tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"date_created":"2018-12-11T11:44:21Z","supervisor":[{"id":"38DB5788-F248-11E8-B48F-1D18A9856A87","first_name":"Georgios","last_name":"Katsaros","orcid":"0000-0001-8342-202X","full_name":"Katsaros, Georgios"}],"status":"public","day":"30","language":[{"iso":"eng"}],"pubrep_id":"1033","article_processing_charge":"No","department":[{"_id":"GeKa"}],"publist_id":"8005","file":[{"file_name":"2018_Thesis_Watzinger.pdf","date_created":"2019-04-09T07:13:28Z","date_updated":"2020-07-14T12:46:35Z","file_id":"6249","content_type":"application/pdf","file_size":85539748,"creator":"dernst","relation":"main_file","checksum":"b653b5216251f938ddbeafd1de88667c","access_level":"open_access"},{"checksum":"39bcf8de7ac5b1bb516b11ce2f966785","relation":"source_file","access_level":"closed","file_size":21830697,"creator":"dernst","file_id":"6250","content_type":"application/zip","date_created":"2019-04-09T07:13:27Z","date_updated":"2020-07-14T12:46:35Z","file_name":"2018_Thesis_Watzinger_source.zip"}],"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","author":[{"full_name":"Watzinger, Hannes","id":"35DF8E50-F248-11E8-B48F-1D18A9856A87","first_name":"Hannes","last_name":"Watzinger"}],"title":"Ge hut wires - from growth to hole spin resonance","has_accepted_license":"1","publisher":"Institute of Science and Technology Austria","publication_status":"published","_id":"49","publication_identifier":{"issn":["2663-337X"]},"citation":{"short":"H. Watzinger, Ge Hut Wires - from Growth to Hole Spin Resonance, Institute of Science and Technology Austria, 2018.","ista":"Watzinger H. 2018. Ge hut wires - from growth to hole spin resonance. Institute of Science and Technology Austria.","ieee":"H. Watzinger, “Ge hut wires - from growth to hole spin resonance,” Institute of Science and Technology Austria, 2018.","ama":"Watzinger H. Ge hut wires - from growth to hole spin resonance. 2018. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:th_1033\">10.15479/AT:ISTA:th_1033</a>","chicago":"Watzinger, Hannes. “Ge Hut Wires - from Growth to Hole Spin Resonance.” Institute of Science and Technology Austria, 2018. <a href=\"https://doi.org/10.15479/AT:ISTA:th_1033\">https://doi.org/10.15479/AT:ISTA:th_1033</a>.","apa":"Watzinger, H. (2018). <i>Ge hut wires - from growth to hole spin resonance</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:th_1033\">https://doi.org/10.15479/AT:ISTA:th_1033</a>","mla":"Watzinger, Hannes. <i>Ge Hut Wires - from Growth to Hole Spin Resonance</i>. Institute of Science and Technology Austria, 2018, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:th_1033\">10.15479/AT:ISTA:th_1033</a>."},"type":"dissertation","file_date_updated":"2020-07-14T12:46:35Z","abstract":[{"lang":"eng","text":"Nowadays, quantum computation is receiving more and more attention as an alternative to the classical way of computing. For realizing a quantum computer, different devices are investigated as potential quantum bits. In this thesis, the focus is on Ge hut wires, which turned out to be promising candidates for implementing hole spin quantum bits. The advantages of Ge as a material system are the low hyperfine interaction for holes and the strong spin orbit coupling, as well as the compatibility with the highly developed CMOS processes in industry. In addition, Ge can also be isotopically purified which is expected to boost the spin coherence times. The strong spin orbit interaction for holes in Ge on the one hand enables the full electrical control of the quantum bit and on the other hand should allow short spin manipulation times. Starting with a bare Si wafer, this work covers the entire process reaching from growth over the fabrication and characterization of hut wire devices up to the demonstration of hole spin resonance. From experiments with single quantum dots, a large g-factor anisotropy between the in-plane and the out-of-plane direction was found. A comparison to a theoretical model unveiled the heavy-hole character of the lowest energy states. The second part of the thesis addresses double quantum dot devices, which were realized by adding two gate electrodes to a hut wire. In such devices, Pauli spin blockade was observed, which can serve as a read-out mechanism for spin quantum bits. Applying oscillating electric fields in spin blockade allowed the demonstration of continuous spin rotations and the extraction of a lower bound for the spin dephasing time. Despite the strong spin orbit coupling in Ge, the obtained value for the dephasing time is comparable to what has been recently reported for holes in Si. All in all, the presented results point out the high potential of Ge hut wires as a platform for long-lived, fast and fully electrically tunable hole spin quantum bits."}]},{"date_updated":"2023-09-07T12:48:16Z","oa":1,"month":"06","date_published":"2018-06-22T00:00:00Z","alternative_title":["ISTA Thesis"],"year":"2018","page":"95","date_created":"2018-12-11T11:44:21Z","ddc":["570","591","596"],"supervisor":[{"id":"39427864-F248-11E8-B48F-1D18A9856A87","first_name":"Carl-Philipp J","orcid":"0000-0002-0912-4566","last_name":"Heisenberg","full_name":"Heisenberg, Carl-Philipp J"}],"status":"public","day":"22","related_material":{"record":[{"id":"1100","status":"public","relation":"part_of_dissertation"},{"status":"public","relation":"part_of_dissertation","id":"661"},{"id":"676","status":"public","relation":"part_of_dissertation"}]},"oa_version":"Published Version","degree_awarded":"PhD","doi":"10.15479/AT:ISTA:TH_1031","file":[{"content_type":"application/pdf","file_id":"6238","creator":"dernst","file_size":31576521,"embargo":"2019-06-25","checksum":"d3eca3dcacb67bffdde6e6609c31cdd0","relation":"main_file","access_level":"open_access","file_name":"2018_Thesis_Capek.pdf","date_updated":"2021-02-11T11:17:17Z","date_created":"2019-04-08T13:42:26Z"},{"date_updated":"2021-02-11T23:30:21Z","date_created":"2019-04-08T13:42:27Z","file_name":"2018_Thesis_Capek_source.docx","checksum":"876deb14067e638aba65d209668bd821","access_level":"closed","relation":"source_file","embargo_to":"open_access","file_size":38992956,"creator":"dernst","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","file_id":"6239"}],"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","author":[{"full_name":"Capek, Daniel","id":"31C42484-F248-11E8-B48F-1D18A9856A87","first_name":"Daniel","orcid":"0000-0001-5199-9940","last_name":"Capek"}],"title":"Optogenetic Frizzled 7 reveals a permissive function of Wnt/PCP signaling in directed mesenchymal cell migration","has_accepted_license":"1","publisher":"Institute of Science and Technology Austria","language":[{"iso":"eng"}],"pubrep_id":"1031","article_processing_charge":"No","department":[{"_id":"CaHe"}],"publist_id":"8004","_id":"50","citation":{"ieee":"D. Capek, “Optogenetic Frizzled 7 reveals a permissive function of Wnt/PCP signaling in directed mesenchymal cell migration,” Institute of Science and Technology Austria, 2018.","short":"D. Capek, Optogenetic Frizzled 7 Reveals a Permissive Function of Wnt/PCP Signaling in Directed Mesenchymal Cell Migration, Institute of Science and Technology Austria, 2018.","ista":"Capek D. 2018. Optogenetic Frizzled 7 reveals a permissive function of Wnt/PCP signaling in directed mesenchymal cell migration. Institute of Science and Technology Austria.","ama":"Capek D. Optogenetic Frizzled 7 reveals a permissive function of Wnt/PCP signaling in directed mesenchymal cell migration. 2018. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:TH_1031\">10.15479/AT:ISTA:TH_1031</a>","chicago":"Capek, Daniel. “Optogenetic Frizzled 7 Reveals a Permissive Function of Wnt/PCP Signaling in Directed Mesenchymal Cell Migration.” Institute of Science and Technology Austria, 2018. <a href=\"https://doi.org/10.15479/AT:ISTA:TH_1031\">https://doi.org/10.15479/AT:ISTA:TH_1031</a>.","apa":"Capek, D. (2018). <i>Optogenetic Frizzled 7 reveals a permissive function of Wnt/PCP signaling in directed mesenchymal cell migration</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:TH_1031\">https://doi.org/10.15479/AT:ISTA:TH_1031</a>","mla":"Capek, Daniel. <i>Optogenetic Frizzled 7 Reveals a Permissive Function of Wnt/PCP Signaling in Directed Mesenchymal Cell Migration</i>. Institute of Science and Technology Austria, 2018, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:TH_1031\">10.15479/AT:ISTA:TH_1031</a>."},"publication_identifier":{"issn":["2663-337X"]},"file_date_updated":"2021-02-11T23:30:21Z","type":"dissertation","abstract":[{"text":"The Wnt/planar cell polarity (Wnt/PCP) pathway determines planar polarity of epithelial cells in both vertebrates and invertebrates. The role that Wnt/PCP signaling plays in mesenchymal contexts, however, is only poorly understood. While previous studies have demonstrated the capacity of Wnt/PCP signaling to polarize and guide directed migration of mesenchymal cells, it remains unclear whether endogenous Wnt/PCP signaling performs these functions instructively, as it does in epithelial cells. Here we developed a light-switchable version of the Wnt/PCP receptor Frizzled 7 (Fz7) to unambiguously distinguish between an instructive and a permissive role of Wnt/PCP signaling for the directional collective migration of mesendoderm progenitor cells during zebrafish gastrulation. We show that prechordal plate (ppl) cell migration is defective in maternal-zygotic fz7a and fz7b (MZ fz7a,b) double mutant embryos, and that Fz7 functions cell-autonomously in this process by promoting ppl cell protrusion formation and directed migration. We further show that local activation of Fz7 can direct ppl cell migration both in vitro and in vivo. Surprisingly, however, uniform Fz7 activation is sufficient to fully rescue the ppl cell migration defect in MZ fz7a,b mutant embryos, indicating that Wnt/PCP signaling functions permissively rather than instructively in directed mesendoderm cell migration during zebrafish gastrulation.","lang":"eng"}],"publication_status":"published"},{"volume":268,"date_created":"2018-12-11T11:46:50Z","day":"20","status":"public","doi":"10.1016/j.jbiotec.2018.01.008","publication":"Journal of Biotechnology","isi":1,"oa_version":"None","intvolume":"       268","month":"02","date_published":"2018-02-20T00:00:00Z","acknowledgement":"We thank R Chait and M Lagator for sharing Bacillus subtilis CR_Y1 and pZS*_2R-cIPtet-Venus-Prm, respectively. We are grateful to T Pilizota and all members of the Guet lab for critically reading the manuscript. We also thank the Bioimaging facility at IST Austria for assistance using the FACSAria III system.\r\n\r\n","date_updated":"2023-09-13T08:24:51Z","acknowledged_ssus":[{"_id":"Bio"}],"page":"40 - 52","external_id":{"isi":["000425715100006"]},"year":"2018","citation":{"apa":"Tomasek, K., Bergmiller, T., &#38; Guet, C. C. (2018). Lack of cations in flow cytometry buffers affect fluorescence signals by reducing membrane stability and viability of Escherichia coli strains. <i>Journal of Biotechnology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.jbiotec.2018.01.008\">https://doi.org/10.1016/j.jbiotec.2018.01.008</a>","mla":"Tomasek, Kathrin, et al. “Lack of Cations in Flow Cytometry Buffers Affect Fluorescence Signals by Reducing Membrane Stability and Viability of Escherichia Coli Strains.” <i>Journal of Biotechnology</i>, vol. 268, Elsevier, 2018, pp. 40–52, doi:<a href=\"https://doi.org/10.1016/j.jbiotec.2018.01.008\">10.1016/j.jbiotec.2018.01.008</a>.","ama":"Tomasek K, Bergmiller T, Guet CC. Lack of cations in flow cytometry buffers affect fluorescence signals by reducing membrane stability and viability of Escherichia coli strains. <i>Journal of Biotechnology</i>. 2018;268:40-52. doi:<a href=\"https://doi.org/10.1016/j.jbiotec.2018.01.008\">10.1016/j.jbiotec.2018.01.008</a>","ieee":"K. Tomasek, T. Bergmiller, and C. C. Guet, “Lack of cations in flow cytometry buffers affect fluorescence signals by reducing membrane stability and viability of Escherichia coli strains,” <i>Journal of Biotechnology</i>, vol. 268. Elsevier, pp. 40–52, 2018.","ista":"Tomasek K, Bergmiller T, Guet CC. 2018. Lack of cations in flow cytometry buffers affect fluorescence signals by reducing membrane stability and viability of Escherichia coli strains. Journal of Biotechnology. 268, 40–52.","short":"K. Tomasek, T. Bergmiller, C.C. Guet, Journal of Biotechnology 268 (2018) 40–52.","chicago":"Tomasek, Kathrin, Tobias Bergmiller, and Calin C Guet. “Lack of Cations in Flow Cytometry Buffers Affect Fluorescence Signals by Reducing Membrane Stability and Viability of Escherichia Coli Strains.” <i>Journal of Biotechnology</i>. Elsevier, 2018. <a href=\"https://doi.org/10.1016/j.jbiotec.2018.01.008\">https://doi.org/10.1016/j.jbiotec.2018.01.008</a>."},"type":"journal_article","abstract":[{"text":"Buffers are essential for diluting bacterial cultures for flow cytometry analysis in order to study bacterial physiology and gene expression parameters based on fluorescence signals. Using a variety of constitutively expressed fluorescent proteins in Escherichia coli K-12 strain MG1655, we found strong artifactual changes in fluorescence levels after dilution into the commonly used flow cytometry buffer phosphate-buffered saline (PBS) and two other buffer solutions, Tris-HCl and M9 salts. These changes appeared very rapidly after dilution, and were linked to increased membrane permeability and loss in cell viability. We observed buffer-related effects in several different E. coli strains, K-12, C and W, but not E. coli B, which can be partially explained by differences in lipopolysaccharide (LPS) and outer membrane composition. Supplementing the buffers with divalent cations responsible for outer membrane stability, Mg2+ and Ca2+, preserved fluorescence signals, membrane integrity and viability of E. coli. Thus, stabilizing the bacterial outer membrane is essential for precise and unbiased measurements of fluorescence parameters using flow cytometry.","lang":"eng"}],"scopus_import":"1","_id":"503","quality_controlled":"1","publication_status":"published","publisher":"Elsevier","title":"Lack of cations in flow cytometry buffers affect fluorescence signals by reducing membrane stability and viability of Escherichia coli strains","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","author":[{"full_name":"Tomasek, Kathrin","first_name":"Kathrin","id":"3AEC8556-F248-11E8-B48F-1D18A9856A87","last_name":"Tomasek","orcid":"0000-0003-3768-877X"},{"full_name":"Bergmiller, Tobias","id":"2C471CFA-F248-11E8-B48F-1D18A9856A87","first_name":"Tobias","last_name":"Bergmiller","orcid":"0000-0001-5396-4346"},{"full_name":"Guet, Calin C","id":"47F8433E-F248-11E8-B48F-1D18A9856A87","first_name":"Calin C","last_name":"Guet","orcid":"0000-0001-6220-2052"}],"article_processing_charge":"No","publist_id":"7317","department":[{"_id":"CaGu"}],"language":[{"iso":"eng"}]},{"department":[{"_id":"RySh"}],"publist_id":"8003","article_processing_charge":"No","pubrep_id":"1032","language":[{"iso":"eng"}],"publisher":"Institute of Science and Technology Austria","has_accepted_license":"1","file":[{"embargo_to":"open_access","file_size":141270528,"creator":"dernst","file_id":"6251","content_type":"application/msword","relation":"source_file","checksum":"dcc7b55619d8509dd62b8e99d6cdee44","access_level":"closed","file_name":"2018_Thesis_Case_Source.doc","date_updated":"2021-02-11T23:30:13Z","date_created":"2019-04-09T07:16:26Z"},{"file_name":"2018_Thesis_Case.pdf","date_updated":"2021-02-11T11:17:14Z","date_created":"2019-04-09T07:16:23Z","content_type":"application/pdf","file_id":"6252","file_size":15193621,"creator":"dernst","checksum":"f69fdd5c8709c4e618aa8c1a1221153d","embargo":"2019-07-05","relation":"main_file","access_level":"open_access"}],"title":"From the left to the right: A tale of asymmetries, environments, and hippocampal development","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","author":[{"full_name":"Case, Matthew J","first_name":"Matthew J","id":"44B7CA5A-F248-11E8-B48F-1D18A9856A87","last_name":"Case"}],"publication_status":"published","file_date_updated":"2021-02-11T23:30:13Z","type":"dissertation","abstract":[{"text":"Asymmetries have long been known about in the central nervous system. From gross anatomical differences, such as the presence of the parapineal organ in only one hemisphere of the developing zebrafish, to more subtle differences in activity between both hemispheres, as seen in freely roaming animals or human participants under PET and fMRI imaging analysis. The presence of asymmetries has been demonstrated to have huge behavioural implications, with their disruption often leading to the generation of neurological disorders, memory problems, changes in personality, and in an organism's health and well-being. For my Ph.D. work I aimed to tackle two important avenues of research. The first being the process of input-side dependency in the hippocampus, with the goal of finding a key gene responsible for its development (Gene X). The second project was to do with experience-induced laterality formation in the hippocampus. Specifically, how laterality in the synapse density of the CA1 stratum radiatum (s.r.) could be induced purely through environmental enrichment. Through unilateral tracer injections into the CA3, I was able to selectively measure the properties of synapses within the CA1 and investigate how they differed based upon which hemisphere the presynaptic neurone originated. Having found the existence of a previously unreported reversed (left-isomerism) i.v. mutant, through morpholocal examination of labelled terminals in the CA1 s.r., I aimed to elucidate a key gene responsible for the process of left or right determination of inputs to the CA1 s.r.. This work relates to the previous finding of input-side dependent asymmetry in the wild-type rodent, where the origin of the projecting neurone to the CA1 will determine the morphology of a synapse, to a greater degree than the hemisphere in which the projection terminates. Using left- and right-isomerism i.v. mice, in combination with whole genome sequence analysis, I highlight Ena/VASP-like (Evl) as a potential target for Gene X. In relation to this topic, I also highlight my work in the recently published paper of how knockout of PirB can lead to a lack of input-side dependency in the murine hippocampus. For the second question, I show that the environmental enrichment paradigm will lead to an asymmetry in the synapse densities in the hippocampus of mice. I also highlight that the nature of the enrichment is of less consequence than the process of enrichment itself. I demonstrate that the CA3 region will dramatically alter its projection targets, in relation to environmental stimulation, with the asymmetry in synaptic density, caused by enrichment, relying heavily on commissural fibres. I also highlight the vital importance of input-side dependent asymmetry, as a necessary component of experience-dependent laterality formation in the CA1 s.r.. However, my results suggest that it isn't the only cause, as there appears to be a CA1 dependent mechanism also at play. Upon further investigation, I highlight the significant, and highly important, finding that the changes seen in the CA1 s.r. were predominantly caused through projections from the left-CA3, with the right-CA3 having less involvement in this mechanism.","lang":"eng"}],"citation":{"mla":"Case, Matthew J. <i>From the Left to the Right: A Tale of Asymmetries, Environments, and Hippocampal Development</i>. Institute of Science and Technology Austria, 2018, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:th_1032\">10.15479/AT:ISTA:th_1032</a>.","apa":"Case, M. J. (2018). <i>From the left to the right: A tale of asymmetries, environments, and hippocampal development</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:th_1032\">https://doi.org/10.15479/AT:ISTA:th_1032</a>","chicago":"Case, Matthew J. “From the Left to the Right: A Tale of Asymmetries, Environments, and Hippocampal Development.” Institute of Science and Technology Austria, 2018. <a href=\"https://doi.org/10.15479/AT:ISTA:th_1032\">https://doi.org/10.15479/AT:ISTA:th_1032</a>.","ama":"Case MJ. From the left to the right: A tale of asymmetries, environments, and hippocampal development. 2018. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:th_1032\">10.15479/AT:ISTA:th_1032</a>","ista":"Case MJ. 2018. From the left to the right: A tale of asymmetries, environments, and hippocampal development. Institute of Science and Technology Austria.","ieee":"M. J. Case, “From the left to the right: A tale of asymmetries, environments, and hippocampal development,” Institute of Science and Technology Austria, 2018.","short":"M.J. Case, From the Left to the Right: A Tale of Asymmetries, Environments, and Hippocampal Development, Institute of Science and Technology Austria, 2018."},"publication_identifier":{"issn":["2663-337X"]},"_id":"51","page":"186","year":"2018","month":"06","date_published":"2018-06-27T00:00:00Z","alternative_title":["ISTA Thesis"],"oa":1,"date_updated":"2023-09-07T12:39:22Z","doi":"10.15479/AT:ISTA:th_1032","degree_awarded":"PhD","oa_version":"Published Version","related_material":{"record":[{"status":"public","relation":"part_of_dissertation","id":"682"}]},"supervisor":[{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","last_name":"Shigemoto","orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi"}],"status":"public","day":"27","date_created":"2018-12-11T11:44:22Z","ddc":["571","576"]},{"doi":"10.1016/j.jmmm.2017.12.073","publication":"Journal of Magnetism and Magnetic Materials","isi":1,"oa_version":"Submitted Version","volume":452,"ddc":["530"],"date_created":"2018-12-11T11:46:56Z","status":"public","day":"15","page":"427 - 441","external_id":{"isi":["000425547700061"]},"year":"2018","month":"04","intvolume":"       452","date_published":"2018-04-15T00:00:00Z","acknowledgement":"S.Altmeyer is a Serra Húnter Fellow","date_updated":"2023-09-13T09:03:44Z","oa":1,"publication_status":"published","citation":{"apa":"Altmeyer, S. (2018). Non-linear dynamics and alternating ‘flip’ solutions in ferrofluidic Taylor-Couette flow. <i>Journal of Magnetism and Magnetic Materials</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.jmmm.2017.12.073\">https://doi.org/10.1016/j.jmmm.2017.12.073</a>","mla":"Altmeyer, Sebastian. “Non-Linear Dynamics and Alternating ‘Flip’ Solutions in Ferrofluidic Taylor-Couette Flow.” <i>Journal of Magnetism and Magnetic Materials</i>, vol. 452, Elsevier, 2018, pp. 427–41, doi:<a href=\"https://doi.org/10.1016/j.jmmm.2017.12.073\">10.1016/j.jmmm.2017.12.073</a>.","ama":"Altmeyer S. Non-linear dynamics and alternating ‘flip’ solutions in ferrofluidic Taylor-Couette flow. <i>Journal of Magnetism and Magnetic Materials</i>. 2018;452:427-441. doi:<a href=\"https://doi.org/10.1016/j.jmmm.2017.12.073\">10.1016/j.jmmm.2017.12.073</a>","short":"S. Altmeyer, Journal of Magnetism and Magnetic Materials 452 (2018) 427–441.","ista":"Altmeyer S. 2018. Non-linear dynamics and alternating ‘flip’ solutions in ferrofluidic Taylor-Couette flow. Journal of Magnetism and Magnetic Materials. 452, 427–441.","ieee":"S. Altmeyer, “Non-linear dynamics and alternating ‘flip’ solutions in ferrofluidic Taylor-Couette flow,” <i>Journal of Magnetism and Magnetic Materials</i>, vol. 452. Elsevier, pp. 427–441, 2018.","chicago":"Altmeyer, Sebastian. “Non-Linear Dynamics and Alternating ‘Flip’ Solutions in Ferrofluidic Taylor-Couette Flow.” <i>Journal of Magnetism and Magnetic Materials</i>. Elsevier, 2018. <a href=\"https://doi.org/10.1016/j.jmmm.2017.12.073\">https://doi.org/10.1016/j.jmmm.2017.12.073</a>."},"file_date_updated":"2020-07-14T12:46:37Z","type":"journal_article","scopus_import":"1","abstract":[{"text":"This study treats with the influence of a symmetry-breaking transversal magnetic field on the nonlinear dynamics of ferrofluidic Taylor-Couette flow – flow confined between two concentric independently rotating cylinders. We detected alternating ‘flip’ solutions which are flow states featuring typical characteristics of slow-fast-dynamics in dynamical systems. The flip corresponds to a temporal change in the axial wavenumber and we find them to appear either as pure 2-fold axisymmetric (due to the symmetry-breaking nature of the applied transversal magnetic field) or involving non-axisymmetric, helical modes in its interim solution. The latter ones show features of typical ribbon solutions. In any case the flip solutions have a preferential first axial wavenumber which corresponds to the more stable state (slow dynamics) and second axial wavenumber, corresponding to the short appearing more unstable state (fast dynamics). However, in both cases the flip time grows exponential with increasing the magnetic field strength before the flip solutions, living on 2-tori invariant manifolds, cease to exist, with lifetime going to infinity. Further we show that ferrofluidic flow turbulence differ from the classical, ordinary (usually at high Reynolds number) turbulence. The applied magnetic field hinders the free motion of ferrofluid partials and therefore smoothen typical turbulent quantities and features so that speaking of mildly chaotic dynamics seems to be a more appropriate expression for the observed motion. ","lang":"eng"}],"_id":"519","quality_controlled":"1","article_processing_charge":"No","publist_id":"7297","department":[{"_id":"BjHo"}],"language":[{"iso":"eng"}],"article_type":"original","has_accepted_license":"1","publisher":"Elsevier","file":[{"date_created":"2020-05-14T14:41:17Z","date_updated":"2020-07-14T12:46:37Z","file_name":"2018_Magnetism_Altmeyer.pdf","relation":"main_file","checksum":"431f5cd4a628d7ca21161f82b14ccb4f","access_level":"open_access","creator":"dernst","file_size":17309535,"file_id":"7838","content_type":"application/pdf"}],"title":"Non-linear dynamics and alternating ‘flip’ solutions in ferrofluidic Taylor-Couette flow","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","author":[{"orcid":"0000-0001-5964-0203","last_name":"Altmeyer","id":"2EE67FDC-F248-11E8-B48F-1D18A9856A87","first_name":"Sebastian","full_name":"Altmeyer, Sebastian"}]}]