[{"day":"01","type":"journal_article","issue":"4","article_processing_charge":"No","isi":1,"related_material":{"record":[{"status":"public","id":"9806","relation":"research_data"}]},"department":[{"_id":"SyCr"}],"article_type":"original","oa_version":"Published Version","volume":88,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"ddc":["570"],"publication":"Journal of Animal Ecology","external_id":{"isi":["000467994800007"]},"status":"public","publication_identifier":{"issn":["00218790"],"eissn":["13652656"]},"project":[{"_id":"25681D80-B435-11E9-9278-68D0E5697425","name":"International IST Postdoc Fellowship Programme","call_identifier":"FP7","grant_number":"291734"}],"intvolume":"        88","file":[{"creator":"dernst","date_updated":"2020-07-14T12:47:19Z","relation":"main_file","access_level":"open_access","checksum":"405cde15120de26018b3bd0dfa29986c","file_name":"2019_JournalAnimalEcology_Kutzer.pdf","file_size":1460662,"content_type":"application/pdf","date_created":"2019-03-18T07:43:06Z","file_id":"6107"}],"language":[{"iso":"eng"}],"doi":"10.1111/1365-2656.12953","page":"566-578","oa":1,"title":"A multi-faceted approach testing the effects of previous bacterial exposure on resistance and tolerance","quality_controlled":"1","author":[{"full_name":"Kutzer, Megan","id":"29D0B332-F248-11E8-B48F-1D18A9856A87","last_name":"Kutzer","first_name":"Megan","orcid":"0000-0002-8696-6978"},{"first_name":"Joachim","last_name":"Kurtz","full_name":"Kurtz, Joachim"},{"full_name":"Armitage, Sophie A.O.","last_name":"Armitage","first_name":"Sophie A.O."}],"year":"2019","has_accepted_license":"1","publication_status":"published","date_created":"2019-03-17T22:59:15Z","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","_id":"6105","ec_funded":1,"date_published":"2019-04-01T00:00:00Z","month":"04","date_updated":"2023-08-25T08:04:53Z","scopus_import":"1","file_date_updated":"2020-07-14T12:47:19Z","abstract":[{"text":"    Hosts can alter their strategy towards pathogens during their lifetime; that is, they can show phenotypic plasticity in immunity or life history. Immune priming is one such example, where a previous encounter with a pathogen confers enhanced protection upon secondary challenge, resulting in reduced pathogen load (i.e., resistance) and improved host survival. However, an initial encounter might also enhance tolerance, particularly to less virulent opportunistic pathogens that establish persistent infections. In this scenario, individuals are better able to reduce the negative fecundity consequences that result from a high pathogen burden. Finally, previous exposure may also lead to life‐history adjustments, such as terminal investment into reproduction.\r\n    Using different Drosophila melanogaster host genotypes and two bacterial pathogens, Lactococcus lactis and Pseudomonas entomophila, we tested whether previous exposure results in resistance or tolerance and whether it modifies immune gene expression during an acute‐phase infection (one day post‐challenge). We then asked whether previous pathogen exposure affects chronic‐phase pathogen persistence and longer‐term survival (28 days post‐challenge).\r\n    We predicted that previous exposure would increase host resistance to an early stage bacterial infection while it might come at a cost to host fecundity tolerance. We reasoned that resistance would be due in part to stronger immune gene expression after challenge. We expected that previous exposure would improve long‐term survival, that it would reduce infection persistence, and we expected to find genetic variation in these responses.\r\n    We found that previous exposure to P. entomophila weakened host resistance to a second infection independent of genotype and had no effect on immune gene expression. Fecundity tolerance showed genotypic variation but was not influenced by previous exposure. However, L. lactis persisted as a chronic infection, whereas survivors cleared the more pathogenic P. entomophila infection.\r\n    To our knowledge, this is the first study that addresses host tolerance to bacteria in relation to previous exposure, taking a multi‐faceted approach to address the topic. Our results suggest that previous exposure comes with transient costs to resistance during the early stage of infection in this host–pathogen system and that infection persistence may be bacterium‐specific.\r\n","lang":"eng"}],"citation":{"short":"M. Kutzer, J. Kurtz, S.A.O. Armitage, Journal of Animal Ecology 88 (2019) 566–578.","ama":"Kutzer M, Kurtz J, Armitage SAO. A multi-faceted approach testing the effects of previous bacterial exposure on resistance and tolerance. <i>Journal of Animal Ecology</i>. 2019;88(4):566-578. doi:<a href=\"https://doi.org/10.1111/1365-2656.12953\">10.1111/1365-2656.12953</a>","chicago":"Kutzer, Megan, Joachim Kurtz, and Sophie A.O. Armitage. “A Multi-Faceted Approach Testing the Effects of Previous Bacterial Exposure on Resistance and Tolerance.” <i>Journal of Animal Ecology</i>. Wiley, 2019. <a href=\"https://doi.org/10.1111/1365-2656.12953\">https://doi.org/10.1111/1365-2656.12953</a>.","mla":"Kutzer, Megan, et al. “A Multi-Faceted Approach Testing the Effects of Previous Bacterial Exposure on Resistance and Tolerance.” <i>Journal of Animal Ecology</i>, vol. 88, no. 4, Wiley, 2019, pp. 566–78, doi:<a href=\"https://doi.org/10.1111/1365-2656.12953\">10.1111/1365-2656.12953</a>.","apa":"Kutzer, M., Kurtz, J., &#38; Armitage, S. A. O. (2019). A multi-faceted approach testing the effects of previous bacterial exposure on resistance and tolerance. <i>Journal of Animal Ecology</i>. Wiley. <a href=\"https://doi.org/10.1111/1365-2656.12953\">https://doi.org/10.1111/1365-2656.12953</a>","ieee":"M. Kutzer, J. Kurtz, and S. A. O. Armitage, “A multi-faceted approach testing the effects of previous bacterial exposure on resistance and tolerance,” <i>Journal of Animal Ecology</i>, vol. 88, no. 4. Wiley, pp. 566–578, 2019.","ista":"Kutzer M, Kurtz J, Armitage SAO. 2019. A multi-faceted approach testing the effects of previous bacterial exposure on resistance and tolerance. Journal of Animal Ecology. 88(4), 566–578."},"publisher":"Wiley"},{"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","date_created":"2019-03-21T12:12:19Z","publication_status":"published","volume":11414,"oa_version":"None","extern":"1","year":"2019","article_processing_charge":"No","type":"conference","conference":{"start_date":"2019-03-26","name":"DGCI: International Conference on Discrete Geometry for Computer Imagery","end_date":"2019-03-28","location":"Marne-la-Vallée, France"},"day":"23","author":[{"full_name":"Biswas, Ranita","first_name":"Ranita","last_name":"Biswas","orcid":"0000-0002-5372-7890","id":"3C2B033E-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Gaëlle","last_name":"Largeteau-Skapin","full_name":"Largeteau-Skapin, Gaëlle"},{"full_name":"Zrour, Rita","first_name":"Rita","last_name":"Zrour"},{"full_name":"Andres, Eric","last_name":"Andres","first_name":"Eric"}],"quality_controlled":"1","title":"Rhombic dodecahedron grid—coordinate system and 3D digital object definitions","place":"Berlin, Heidelberg","publisher":"Springer Berlin Heidelberg","page":"27-37","doi":"10.1007/978-3-030-14085-4_3","language":[{"iso":"eng"}],"alternative_title":["LNCS"],"abstract":[{"text":"We propose a new non-orthogonal basis to express the 3D Euclidean space in terms of a regular grid. Every grid point, each represented by integer 3-coordinates, corresponds to rhombic dodecahedron centroid. Rhombic dodecahedron is a space filling polyhedron which represents the close packing of spheres in 3D space and the Voronoi structures of the face centered cubic (FCC) lattice. In order to illustrate the interest of the new coordinate system, we propose the characterization of 3D digital plane with its topological features, such as the interrelation between the thickness of the digital plane and the separability constraint we aim to obtain. A characterization of a 3D digital sphere with relevant topological features is proposed as well with the help of a 48 symmetry that comes with the new coordinate system.","lang":"eng"}],"citation":{"ieee":"R. Biswas, G. Largeteau-Skapin, R. Zrour, and E. Andres, “Rhombic dodecahedron grid—coordinate system and 3D digital object definitions,” in <i>21st IAPR International Conference on Discrete Geometry for Computer Imagery</i>, Marne-la-Vallée, France, 2019, vol. 11414, pp. 27–37.","ista":"Biswas R, Largeteau-Skapin G, Zrour R, Andres E. 2019. Rhombic dodecahedron grid—coordinate system and 3D digital object definitions. 21st IAPR International Conference on Discrete Geometry for Computer Imagery. DGCI: International Conference on Discrete Geometry for Computer Imagery, LNCS, vol. 11414, 27–37.","short":"R. Biswas, G. Largeteau-Skapin, R. Zrour, E. Andres, in:, 21st IAPR International Conference on Discrete Geometry for Computer Imagery, Springer Berlin Heidelberg, Berlin, Heidelberg, 2019, pp. 27–37.","ama":"Biswas R, Largeteau-Skapin G, Zrour R, Andres E. Rhombic dodecahedron grid—coordinate system and 3D digital object definitions. In: <i>21st IAPR International Conference on Discrete Geometry for Computer Imagery</i>. Vol 11414. Berlin, Heidelberg: Springer Berlin Heidelberg; 2019:27-37. doi:<a href=\"https://doi.org/10.1007/978-3-030-14085-4_3\">10.1007/978-3-030-14085-4_3</a>","chicago":"Biswas, Ranita, Gaëlle Largeteau-Skapin, Rita Zrour, and Eric Andres. “Rhombic Dodecahedron Grid—Coordinate System and 3D Digital Object Definitions.” In <i>21st IAPR International Conference on Discrete Geometry for Computer Imagery</i>, 11414:27–37. Berlin, Heidelberg: Springer Berlin Heidelberg, 2019. <a href=\"https://doi.org/10.1007/978-3-030-14085-4_3\">https://doi.org/10.1007/978-3-030-14085-4_3</a>.","mla":"Biswas, Ranita, et al. “Rhombic Dodecahedron Grid—Coordinate System and 3D Digital Object Definitions.” <i>21st IAPR International Conference on Discrete Geometry for Computer Imagery</i>, vol. 11414, Springer Berlin Heidelberg, 2019, pp. 27–37, doi:<a href=\"https://doi.org/10.1007/978-3-030-14085-4_3\">10.1007/978-3-030-14085-4_3</a>.","apa":"Biswas, R., Largeteau-Skapin, G., Zrour, R., &#38; Andres, E. (2019). Rhombic dodecahedron grid—coordinate system and 3D digital object definitions. In <i>21st IAPR International Conference on Discrete Geometry for Computer Imagery</i> (Vol. 11414, pp. 27–37). Berlin, Heidelberg: Springer Berlin Heidelberg. <a href=\"https://doi.org/10.1007/978-3-030-14085-4_3\">https://doi.org/10.1007/978-3-030-14085-4_3</a>"},"intvolume":"     11414","date_updated":"2022-01-27T14:25:17Z","month":"02","status":"public","publication_identifier":{"isbn":["978-3-6624-6446-5","978-3-6624-6447-2"],"issn":["0302-9743","1611-3349"]},"date_published":"2019-02-23T00:00:00Z","publication":"21st IAPR International Conference on Discrete Geometry for Computer Imagery","_id":"6163"},{"date_created":"2019-03-25T07:32:08Z","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","publication_status":"published","author":[{"full_name":"Dumitrescu, Philipp T.","first_name":"Philipp T.","last_name":"Dumitrescu"},{"full_name":"Goremykina, Anna","last_name":"Goremykina","first_name":"Anna"},{"first_name":"Siddharth A.","last_name":"Parameswaran","full_name":"Parameswaran, Siddharth A."},{"full_name":"Serbyn, Maksym","last_name":"Serbyn","first_name":"Maksym","orcid":"0000-0002-2399-5827","id":"47809E7E-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Romain","last_name":"Vasseur","full_name":"Vasseur, Romain"}],"year":"2019","publisher":"American Physical Society","abstract":[{"lang":"eng","text":"We propose a scaling theory for the many-body localization (MBL) phase transition in one dimension, building on the idea that it proceeds via a “quantum avalanche.” We argue that the critical properties can be captured at a coarse-grained level by a Kosterlitz-Thouless (KT) renormalization group (RG) flow. On phenomenological grounds, we identify the scaling variables as the density of thermal regions and the length scale that controls the decay of typical matrix elements. Within this KT picture, the MBL phase is a line of fixed points that terminates at the delocalization transition. We discuss two possible scenarios distinguished by the distribution of rare, fractal thermal inclusions within the MBL phase. In the first scenario, these regions have a stretched exponential distribution in the MBL phase. In the second scenario, the near-critical MBL phase hosts rare thermal regions that are power-law-distributed in size. This points to the existence of a second transition within the MBL phase, at which these power laws change to the stretched exponential form expected at strong disorder. We numerically simulate two different phenomenological RGs previously proposed to describe the MBL transition. Both RGs display a universal power-law length distribution of thermal regions at the transition with a critical exponent αc=2, and continuously varying exponents in the MBL phase consistent with the KT picture."}],"citation":{"apa":"Dumitrescu, P. T., Goremykina, A., Parameswaran, S. A., Serbyn, M., &#38; Vasseur, R. (2019). Kosterlitz-Thouless scaling at many-body localization phase transitions. <i>Physical Review B</i>. American Physical Society. <a href=\"https://doi.org/10.1103/physrevb.99.094205\">https://doi.org/10.1103/physrevb.99.094205</a>","mla":"Dumitrescu, Philipp T., et al. “Kosterlitz-Thouless Scaling at Many-Body Localization Phase Transitions.” <i>Physical Review B</i>, vol. 99, no. 9, 094205, American Physical Society, 2019, doi:<a href=\"https://doi.org/10.1103/physrevb.99.094205\">10.1103/physrevb.99.094205</a>.","chicago":"Dumitrescu, Philipp T., Anna Goremykina, Siddharth A. Parameswaran, Maksym Serbyn, and Romain Vasseur. “Kosterlitz-Thouless Scaling at Many-Body Localization Phase Transitions.” <i>Physical Review B</i>. American Physical Society, 2019. <a href=\"https://doi.org/10.1103/physrevb.99.094205\">https://doi.org/10.1103/physrevb.99.094205</a>.","short":"P.T. Dumitrescu, A. Goremykina, S.A. Parameswaran, M. Serbyn, R. Vasseur, Physical Review B 99 (2019).","ama":"Dumitrescu PT, Goremykina A, Parameswaran SA, Serbyn M, Vasseur R. Kosterlitz-Thouless scaling at many-body localization phase transitions. <i>Physical Review B</i>. 2019;99(9). doi:<a href=\"https://doi.org/10.1103/physrevb.99.094205\">10.1103/physrevb.99.094205</a>","ista":"Dumitrescu PT, Goremykina A, Parameswaran SA, Serbyn M, Vasseur R. 2019. Kosterlitz-Thouless scaling at many-body localization phase transitions. Physical Review B. 99(9), 094205.","ieee":"P. T. Dumitrescu, A. Goremykina, S. A. Parameswaran, M. Serbyn, and R. Vasseur, “Kosterlitz-Thouless scaling at many-body localization phase transitions,” <i>Physical Review B</i>, vol. 99, no. 9. American Physical Society, 2019."},"month":"03","date_updated":"2023-09-05T12:11:13Z","scopus_import":"1","_id":"6174","date_published":"2019-03-22T00:00:00Z","arxiv":1,"oa_version":"Preprint","article_number":"094205","volume":99,"article_type":"original","department":[{"_id":"MaSe"}],"day":"22","type":"journal_article","article_processing_charge":"No","isi":1,"issue":"9","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1811.03103"}],"oa":1,"title":"Kosterlitz-Thouless scaling at many-body localization phase transitions","quality_controlled":"1","intvolume":"        99","language":[{"iso":"eng"}],"doi":"10.1103/physrevb.99.094205","publication_identifier":{"eissn":["2469-9969"],"issn":["2469-9950"]},"status":"public","publication":"Physical Review B","external_id":{"isi":["000462883200001"],"arxiv":["1811.03103"]}},{"ddc":["000"],"external_id":{"arxiv":["1902.04659"],"isi":["000523190300014"]},"publication":"PLDI 2019: Proceedings of the 40th ACM SIGPLAN Conference on Programming Language Design and Implementation","project":[{"_id":"25892FC0-B435-11E9-9278-68D0E5697425","name":"Efficient Algorithms for Computer Aided Verification","grant_number":"ICT15-003"},{"name":"Game Theory","_id":"25863FF4-B435-11E9-9278-68D0E5697425","grant_number":"S11407","call_identifier":"FWF"},{"name":"Rigorous Systems Engineering","_id":"25832EC2-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","grant_number":"S 11407_N23"},{"grant_number":"279307","call_identifier":"FP7","_id":"2581B60A-B435-11E9-9278-68D0E5697425","name":"Quantitative Graph Games: Theory and Applications"},{"name":"Quantitative Game-theoretic Analysis of Blockchain Applications and Smart Contracts","_id":"266EEEC0-B435-11E9-9278-68D0E5697425"}],"status":"public","language":[{"iso":"eng"}],"doi":"10.1145/3314221.3314581","file":[{"file_size":4051066,"content_type":"application/pdf","file_id":"6176","date_created":"2019-03-25T10:11:22Z","access_level":"open_access","relation":"main_file","file_name":"paper.pdf","checksum":"703a5e9b8c8587f2a44085ffd9a4db64","date_updated":"2020-07-14T12:47:20Z","creator":"akafshda"}],"title":"Cost analysis of nondeterministic probabilistic programs","quality_controlled":"1","page":"204-220","oa":1,"isi":1,"article_processing_charge":"No","related_material":{"record":[{"id":"5457","relation":"earlier_version","status":"public"},{"relation":"dissertation_contains","id":"8934","status":"public"}]},"type":"conference","day":"08","conference":{"start_date":"2019-06-22","location":"Phoenix, AZ, United States","end_date":"2019-06-26","name":"PLDI: Conference on Programming Language Design and Implementation"},"department":[{"_id":"KrCh"}],"keyword":["Program Cost Analysis","Program Termination","Probabilistic Programs","Martingales"],"oa_version":"Submitted Version","arxiv":1,"ec_funded":1,"date_published":"2019-06-08T00:00:00Z","_id":"6175","month":"06","date_updated":"2025-06-02T08:53:45Z","scopus_import":"1","citation":{"ieee":"P. Wang, H. Fu, A. K. Goharshady, K. Chatterjee, X. Qin, and W. Shi, “Cost analysis of nondeterministic probabilistic programs,” in <i>PLDI 2019: Proceedings of the 40th ACM SIGPLAN Conference on Programming Language Design and Implementation</i>, Phoenix, AZ, United States, 2019, pp. 204–220.","ista":"Wang P, Fu H, Goharshady AK, Chatterjee K, Qin X, Shi W. 2019. Cost analysis of nondeterministic probabilistic programs. PLDI 2019: Proceedings of the 40th ACM SIGPLAN Conference on Programming Language Design and Implementation. PLDI: Conference on Programming Language Design and Implementation, 204–220.","short":"P. Wang, H. Fu, A.K. Goharshady, K. Chatterjee, X. Qin, W. Shi, in:, PLDI 2019: Proceedings of the 40th ACM SIGPLAN Conference on Programming Language Design and Implementation, Association for Computing Machinery, 2019, pp. 204–220.","ama":"Wang P, Fu H, Goharshady AK, Chatterjee K, Qin X, Shi W. Cost analysis of nondeterministic probabilistic programs. In: <i>PLDI 2019: Proceedings of the 40th ACM SIGPLAN Conference on Programming Language Design and Implementation</i>. Association for Computing Machinery; 2019:204-220. doi:<a href=\"https://doi.org/10.1145/3314221.3314581\">10.1145/3314221.3314581</a>","chicago":"Wang, Peixin, Hongfei Fu, Amir Kafshdar Goharshady, Krishnendu Chatterjee, Xudong Qin, and Wenjun Shi. “Cost Analysis of Nondeterministic Probabilistic Programs.” In <i>PLDI 2019: Proceedings of the 40th ACM SIGPLAN Conference on Programming Language Design and Implementation</i>, 204–20. Association for Computing Machinery, 2019. <a href=\"https://doi.org/10.1145/3314221.3314581\">https://doi.org/10.1145/3314221.3314581</a>.","mla":"Wang, Peixin, et al. “Cost Analysis of Nondeterministic Probabilistic Programs.” <i>PLDI 2019: Proceedings of the 40th ACM SIGPLAN Conference on Programming Language Design and Implementation</i>, Association for Computing Machinery, 2019, pp. 204–20, doi:<a href=\"https://doi.org/10.1145/3314221.3314581\">10.1145/3314221.3314581</a>.","apa":"Wang, P., Fu, H., Goharshady, A. K., Chatterjee, K., Qin, X., &#38; Shi, W. (2019). Cost analysis of nondeterministic probabilistic programs. In <i>PLDI 2019: Proceedings of the 40th ACM SIGPLAN Conference on Programming Language Design and Implementation</i> (pp. 204–220). Phoenix, AZ, United States: Association for Computing Machinery. <a href=\"https://doi.org/10.1145/3314221.3314581\">https://doi.org/10.1145/3314221.3314581</a>"},"file_date_updated":"2020-07-14T12:47:20Z","abstract":[{"text":"We consider the problem of expected cost analysis over nondeterministic probabilistic programs,\r\nwhich aims at automated methods for analyzing the resource-usage of such programs.\r\nPrevious approaches for this problem could only handle nonnegative bounded costs.\r\nHowever, in many scenarios, such as queuing networks or analysis of cryptocurrency protocols,\r\nboth positive and negative costs are necessary and the costs are unbounded as well.\r\n\r\nIn this work, we present a sound and efficient approach to obtain polynomial bounds on the\r\nexpected accumulated cost of nondeterministic probabilistic programs.\r\nOur approach can handle (a) general positive and negative costs with bounded updates in\r\nvariables; and (b) nonnegative costs with general updates to variables.\r\nWe show that several natural examples which could not be\r\nhandled by previous approaches are captured in our framework.\r\n\r\nMoreover, our approach leads to an efficient polynomial-time algorithm, while no\r\nprevious approach for cost analysis of probabilistic programs could guarantee polynomial runtime.\r\nFinally, we show the effectiveness of our approach using experimental results on a variety of programs for which we efficiently synthesize tight resource-usage bounds.","lang":"eng"}],"publisher":"Association for Computing Machinery","year":"2019","has_accepted_license":"1","author":[{"first_name":"Peixin","last_name":"Wang","full_name":"Wang, Peixin"},{"full_name":"Fu, Hongfei","id":"3AAD03D6-F248-11E8-B48F-1D18A9856A87","first_name":"Hongfei","last_name":"Fu"},{"full_name":"Goharshady, Amir Kafshdar","first_name":"Amir Kafshdar","last_name":"Goharshady","orcid":"0000-0003-1702-6584","id":"391365CE-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Chatterjee, Krishnendu","first_name":"Krishnendu","orcid":"0000-0002-4561-241X","last_name":"Chatterjee","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Qin, Xudong","last_name":"Qin","first_name":"Xudong"},{"full_name":"Shi, Wenjun","first_name":"Wenjun","last_name":"Shi"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","publication_status":"published","date_created":"2019-03-25T10:13:25Z"},{"publisher":"Institute of Science and Technology Austria","abstract":[{"text":"In the first part of this thesis we consider large random matrices with arbitrary expectation and a general slowly decaying correlation among its entries. We prove universality of the local eigenvalue statistics and optimal local laws for the resolvent in the bulk and edge regime. The main novel tool is a systematic diagrammatic control of a multivariate cumulant expansion.\r\nIn the second part we consider Wigner-type matrices and show that at any cusp singularity of the limiting eigenvalue distribution the local eigenvalue statistics are uni- versal and form a Pearcey process. Since the density of states typically exhibits only square root or cubic root cusp singularities, our work complements previous results on the bulk and edge universality and it thus completes the resolution of the Wigner- Dyson-Mehta universality conjecture for the last remaining universality type. Our analysis holds not only for exact cusps, but approximate cusps as well, where an ex- tended Pearcey process emerges. As a main technical ingredient we prove an optimal local law at the cusp, and extend the fast relaxation to equilibrium of the Dyson Brow- nian motion to the cusp regime.\r\nIn the third and final part we explore the entrywise linear statistics of Wigner ma- trices and identify the fluctuations for a large class of test functions with little regularity. This enables us to study the rectangular Young diagram obtained from the interlacing eigenvalues of the random matrix and its minor, and we find that, despite having the same limit, the fluctuations differ from those of the algebraic Young tableaux equipped with the Plancharel measure.","lang":"eng"}],"file_date_updated":"2020-07-14T12:47:21Z","citation":{"chicago":"Schröder, Dominik J. “From Dyson to Pearcey: Universal Statistics in Random Matrix Theory.” Institute of Science and Technology Austria, 2019. <a href=\"https://doi.org/10.15479/AT:ISTA:th6179\">https://doi.org/10.15479/AT:ISTA:th6179</a>.","short":"D.J. Schröder, From Dyson to Pearcey: Universal Statistics in Random Matrix Theory, Institute of Science and Technology Austria, 2019.","ama":"Schröder DJ. From Dyson to Pearcey: Universal statistics in random matrix theory. 2019. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:th6179\">10.15479/AT:ISTA:th6179</a>","apa":"Schröder, D. J. (2019). <i>From Dyson to Pearcey: Universal statistics in random matrix theory</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:th6179\">https://doi.org/10.15479/AT:ISTA:th6179</a>","mla":"Schröder, Dominik J. <i>From Dyson to Pearcey: Universal Statistics in Random Matrix Theory</i>. Institute of Science and Technology Austria, 2019, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:th6179\">10.15479/AT:ISTA:th6179</a>.","ieee":"D. J. Schröder, “From Dyson to Pearcey: Universal statistics in random matrix theory,” Institute of Science and Technology Austria, 2019.","ista":"Schröder DJ. 2019. From Dyson to Pearcey: Universal statistics in random matrix theory. Institute of Science and Technology Austria."},"date_updated":"2024-02-22T14:34:33Z","month":"03","date_published":"2019-03-18T00:00:00Z","ec_funded":1,"_id":"6179","publication_status":"published","date_created":"2019-03-28T08:58:59Z","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","degree_awarded":"PhD","has_accepted_license":"1","year":"2019","author":[{"full_name":"Schröder, Dominik J","id":"408ED176-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2904-1856","last_name":"Schröder","first_name":"Dominik J"}],"title":"From Dyson to Pearcey: Universal statistics in random matrix theory","oa":1,"page":"375","doi":"10.15479/AT:ISTA:th6179","language":[{"iso":"eng"}],"alternative_title":["ISTA Thesis"],"file":[{"date_updated":"2020-07-14T12:47:21Z","creator":"dernst","file_id":"6180","date_created":"2019-03-28T08:53:52Z","content_type":"application/x-gzip","file_size":7104482,"checksum":"6926f66f28079a81c4937e3764be00fc","file_name":"2019_Schroeder_Thesis.tar.gz","relation":"source_file","access_level":"closed"},{"creator":"dernst","date_updated":"2020-07-14T12:47:21Z","file_name":"2019_Schroeder_Thesis.pdf","checksum":"7d0ebb8d1207e89768cdd497a5bf80fb","access_level":"open_access","relation":"main_file","file_id":"6181","date_created":"2019-03-28T08:53:52Z","content_type":"application/pdf","file_size":4228794}],"project":[{"name":"Random matrices, universality and disordered quantum systems","_id":"258DCDE6-B435-11E9-9278-68D0E5697425","grant_number":"338804","call_identifier":"FP7"}],"status":"public","publication_identifier":{"issn":["2663-337X"]},"ddc":["515","519"],"oa_version":"Published Version","department":[{"_id":"LaEr"}],"supervisor":[{"full_name":"Erdös, László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","last_name":"Erdös","first_name":"László","orcid":"0000-0001-5366-9603"}],"related_material":{"record":[{"id":"1144","relation":"part_of_dissertation","status":"public"},{"status":"public","relation":"part_of_dissertation","id":"6186"},{"id":"6185","relation":"part_of_dissertation","status":"public"},{"id":"6182","relation":"part_of_dissertation","status":"public"},{"status":"public","relation":"part_of_dissertation","id":"1012"},{"relation":"part_of_dissertation","id":"6184","status":"public"}]},"article_processing_charge":"No","type":"dissertation","day":"18"},{"day":"26","type":"journal_article","isi":1,"article_processing_charge":"No","related_material":{"record":[{"status":"public","id":"6179","relation":"dissertation_contains"}]},"department":[{"_id":"LaEr"}],"article_type":"original","oa_version":"Published Version","arxiv":1,"article_number":"e8","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"volume":7,"ddc":["510"],"publication":"Forum of Mathematics, Sigma","external_id":{"arxiv":["1705.10661"],"isi":["000488847100001"]},"publication_identifier":{"eissn":["20505094"]},"status":"public","project":[{"grant_number":"338804","call_identifier":"FP7","_id":"258DCDE6-B435-11E9-9278-68D0E5697425","name":"Random matrices, universality and disordered quantum systems"}],"intvolume":"         7","file":[{"creator":"dernst","date_updated":"2020-07-14T12:47:22Z","relation":"main_file","access_level":"open_access","checksum":"933a472568221c73b2c3ce8c87bf6d15","file_name":"2019_Forum_Erdoes.pdf","content_type":"application/pdf","file_size":1520344,"file_id":"6883","date_created":"2019-09-17T14:24:13Z"}],"language":[{"iso":"eng"}],"doi":"10.1017/fms.2019.2","oa":1,"title":"Random matrices with slow correlation decay","quality_controlled":"1","author":[{"id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","first_name":"László","last_name":"Erdös","orcid":"0000-0001-5366-9603","full_name":"Erdös, László"},{"full_name":"Krüger, Torben H","id":"3020C786-F248-11E8-B48F-1D18A9856A87","first_name":"Torben H","last_name":"Krüger","orcid":"0000-0002-4821-3297"},{"last_name":"Schröder","first_name":"Dominik J","orcid":"0000-0002-2904-1856","id":"408ED176-F248-11E8-B48F-1D18A9856A87","full_name":"Schröder, Dominik J"}],"year":"2019","has_accepted_license":"1","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","publication_status":"published","date_created":"2019-03-28T09:05:23Z","_id":"6182","ec_funded":1,"date_published":"2019-03-26T00:00:00Z","month":"03","scopus_import":"1","date_updated":"2023-09-07T12:54:12Z","abstract":[{"text":"We consider large random matrices with a general slowly decaying correlation among its entries. We prove universality of the local eigenvalue statistics and optimal local laws for the resolvent away from the spectral edges, generalizing the recent result of Ajanki et al. [‘Stability of the matrix Dyson equation and random matrices with correlations’, Probab. Theory Related Fields 173(1–2) (2019), 293–373] to allow slow correlation decay and arbitrary expectation. The main novel tool is\r\na systematic diagrammatic control of a multivariate cumulant expansion.","lang":"eng"}],"file_date_updated":"2020-07-14T12:47:22Z","citation":{"ama":"Erdös L, Krüger TH, Schröder DJ. Random matrices with slow correlation decay. <i>Forum of Mathematics, Sigma</i>. 2019;7. doi:<a href=\"https://doi.org/10.1017/fms.2019.2\">10.1017/fms.2019.2</a>","short":"L. Erdös, T.H. Krüger, D.J. Schröder, Forum of Mathematics, Sigma 7 (2019).","chicago":"Erdös, László, Torben H Krüger, and Dominik J Schröder. “Random Matrices with Slow Correlation Decay.” <i>Forum of Mathematics, Sigma</i>. Cambridge University Press, 2019. <a href=\"https://doi.org/10.1017/fms.2019.2\">https://doi.org/10.1017/fms.2019.2</a>.","mla":"Erdös, László, et al. “Random Matrices with Slow Correlation Decay.” <i>Forum of Mathematics, Sigma</i>, vol. 7, e8, Cambridge University Press, 2019, doi:<a href=\"https://doi.org/10.1017/fms.2019.2\">10.1017/fms.2019.2</a>.","apa":"Erdös, L., Krüger, T. H., &#38; Schröder, D. J. (2019). Random matrices with slow correlation decay. <i>Forum of Mathematics, Sigma</i>. Cambridge University Press. <a href=\"https://doi.org/10.1017/fms.2019.2\">https://doi.org/10.1017/fms.2019.2</a>","ieee":"L. Erdös, T. H. Krüger, and D. J. Schröder, “Random matrices with slow correlation decay,” <i>Forum of Mathematics, Sigma</i>, vol. 7. Cambridge University Press, 2019.","ista":"Erdös L, Krüger TH, Schröder DJ. 2019. Random matrices with slow correlation decay. Forum of Mathematics, Sigma. 7, e8."},"publisher":"Cambridge University Press"},{"oa_version":"Preprint","arxiv":1,"volume":1,"article_type":"original","department":[{"_id":"LaEr"}],"day":"12","type":"journal_article","related_material":{"record":[{"relation":"dissertation_contains","id":"6179","status":"public"}]},"issue":"4","article_processing_charge":"No","main_file_link":[{"url":"https://arxiv.org/abs/1811.04055","open_access":"1"}],"oa":1,"page":"615–707","quality_controlled":"1","title":"Cusp universality for random matrices, II: The real symmetric case","intvolume":"         1","doi":"10.2140/paa.2019.1.615","language":[{"iso":"eng"}],"status":"public","publication_identifier":{"eissn":["2578-5885"],"issn":["2578-5893"]},"project":[{"grant_number":"338804","call_identifier":"FP7","_id":"258DCDE6-B435-11E9-9278-68D0E5697425","name":"Random matrices, universality and disordered quantum systems"},{"name":"International IST Doctoral Program","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","grant_number":"665385","call_identifier":"H2020"}],"external_id":{"arxiv":["1811.04055"]},"publication":"Pure and Applied Analysis ","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_status":"published","date_created":"2019-03-28T10:21:17Z","author":[{"last_name":"Cipolloni","first_name":"Giorgio","orcid":"0000-0002-4901-7992","id":"42198EFA-F248-11E8-B48F-1D18A9856A87","full_name":"Cipolloni, Giorgio"},{"full_name":"Erdös, László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","last_name":"Erdös","first_name":"László","orcid":"0000-0001-5366-9603"},{"full_name":"Krüger, Torben H","id":"3020C786-F248-11E8-B48F-1D18A9856A87","first_name":"Torben H","last_name":"Krüger","orcid":"0000-0002-4821-3297"},{"first_name":"Dominik J","orcid":"0000-0002-2904-1856","last_name":"Schröder","id":"408ED176-F248-11E8-B48F-1D18A9856A87","full_name":"Schröder, Dominik J"}],"year":"2019","publisher":"MSP","abstract":[{"lang":"eng","text":"We prove that the local eigenvalue statistics of real symmetric Wigner-type\r\nmatrices near the cusp points of the eigenvalue density are universal. Together\r\nwith the companion paper [arXiv:1809.03971], which proves the same result for\r\nthe complex Hermitian symmetry class, this completes the last remaining case of\r\nthe Wigner-Dyson-Mehta universality conjecture after bulk and edge\r\nuniversalities have been established in the last years. We extend the recent\r\nDyson Brownian motion analysis at the edge [arXiv:1712.03881] to the cusp\r\nregime using the optimal local law from [arXiv:1809.03971] and the accurate\r\nlocal shape analysis of the density from [arXiv:1506.05095, arXiv:1804.07752].\r\nWe also present a PDE-based method to improve the estimate on eigenvalue\r\nrigidity via the maximum principle of the heat flow related to the Dyson\r\nBrownian motion."}],"citation":{"chicago":"Cipolloni, Giorgio, László Erdös, Torben H Krüger, and Dominik J Schröder. “Cusp Universality for Random Matrices, II: The Real Symmetric Case.” <i>Pure and Applied Analysis </i>. MSP, 2019. <a href=\"https://doi.org/10.2140/paa.2019.1.615\">https://doi.org/10.2140/paa.2019.1.615</a>.","short":"G. Cipolloni, L. Erdös, T.H. Krüger, D.J. Schröder, Pure and Applied Analysis  1 (2019) 615–707.","ama":"Cipolloni G, Erdös L, Krüger TH, Schröder DJ. Cusp universality for random matrices, II: The real symmetric case. <i>Pure and Applied Analysis </i>. 2019;1(4):615–707. doi:<a href=\"https://doi.org/10.2140/paa.2019.1.615\">10.2140/paa.2019.1.615</a>","apa":"Cipolloni, G., Erdös, L., Krüger, T. H., &#38; Schröder, D. J. (2019). Cusp universality for random matrices, II: The real symmetric case. <i>Pure and Applied Analysis </i>. MSP. <a href=\"https://doi.org/10.2140/paa.2019.1.615\">https://doi.org/10.2140/paa.2019.1.615</a>","mla":"Cipolloni, Giorgio, et al. “Cusp Universality for Random Matrices, II: The Real Symmetric Case.” <i>Pure and Applied Analysis </i>, vol. 1, no. 4, MSP, 2019, pp. 615–707, doi:<a href=\"https://doi.org/10.2140/paa.2019.1.615\">10.2140/paa.2019.1.615</a>.","ieee":"G. Cipolloni, L. Erdös, T. H. Krüger, and D. J. Schröder, “Cusp universality for random matrices, II: The real symmetric case,” <i>Pure and Applied Analysis </i>, vol. 1, no. 4. MSP, pp. 615–707, 2019.","ista":"Cipolloni G, Erdös L, Krüger TH, Schröder DJ. 2019. Cusp universality for random matrices, II: The real symmetric case. Pure and Applied Analysis . 1(4), 615–707."},"date_updated":"2023-09-07T12:54:12Z","month":"10","_id":"6186","date_published":"2019-10-12T00:00:00Z","ec_funded":1},{"publication_identifier":{"issn":["2050-084X"]},"status":"public","project":[{"grant_number":"24283","name":"Examination of the role of a MFS transporter in the migration of Drosophila immune cells","_id":"253CDE40-B435-11E9-9278-68D0E5697425"},{"_id":"253B6E48-B435-11E9-9278-68D0E5697425","name":"The role of Drosophila TNF alpha in immune cell invasion","grant_number":"P29638","call_identifier":"FWF"},{"grant_number":"334077","call_identifier":"FP7","name":"Investigating the role of transporters in invasive migration through junctions","_id":"2536F660-B435-11E9-9278-68D0E5697425"},{"grant_number":"329540","call_identifier":"FP7","name":"Breaking barriers: Investigating the junctional and mechanobiological changes underlying the ability of Drosophila immune cells to invade an epithelium","_id":"25388084-B435-11E9-9278-68D0E5697425"},{"call_identifier":"H2020","grant_number":"665385","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","name":"International IST Doctoral Program"}],"acknowledged_ssus":[{"_id":"LifeSc"}],"ddc":["570"],"external_id":{"isi":["000462530200001"]},"publication":"eLife","oa":1,"title":"A conserved major facilitator superfamily member orchestrates a subset of O-glycosylation to aid macrophage tissue invasion","quality_controlled":"1","intvolume":"         8","file":[{"file_name":"2019_eLife_Valoskova.pdf","checksum":"cc0d1a512559d52e7e7cb0e9b9854b40","access_level":"open_access","relation":"main_file","date_created":"2019-03-28T14:00:41Z","file_id":"6188","content_type":"application/pdf","file_size":4496017,"creator":"dernst","date_updated":"2020-07-14T12:47:23Z"}],"language":[{"iso":"eng"}],"doi":"10.7554/elife.41801","department":[{"_id":"DaSi"}],"day":"26","type":"journal_article","isi":1,"article_processing_charge":"No","related_material":{"record":[{"id":"6530","relation":"dissertation_contains"},{"relation":"dissertation_contains","id":"8983","status":"public"},{"id":"6546","relation":"dissertation_contains","status":"public"}],"link":[{"description":"News on IST Homepage","relation":"press_release","url":"https://ist.ac.at/en/news/new-gene-potentially-involved-in-metastasis-identified/"}]},"oa_version":"Published Version","article_number":"e41801","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"volume":8,"month":"03","date_updated":"2024-03-25T23:30:15Z","scopus_import":"1","_id":"6187","ec_funded":1,"date_published":"2019-03-26T00:00:00Z","publisher":"eLife Sciences Publications","citation":{"ieee":"K. Valosková <i>et al.</i>, “A conserved major facilitator superfamily member orchestrates a subset of O-glycosylation to aid macrophage tissue invasion,” <i>eLife</i>, vol. 8. eLife Sciences Publications, 2019.","ista":"Valosková K, Bicher J, Roblek M, Emtenani S, György A, Misova M, Ratheesh A, Rodrigues P, Shkarina K, Larsen ISB, Vakhrushev SY, Clausen H, Siekhaus DE. 2019. A conserved major facilitator superfamily member orchestrates a subset of O-glycosylation to aid macrophage tissue invasion. eLife. 8, e41801.","chicago":"Valosková, Katarina, Julia Bicher, Marko Roblek, Shamsi Emtenani, Attila György, Michaela Misova, Aparna Ratheesh, et al. “A Conserved Major Facilitator Superfamily Member Orchestrates a Subset of O-Glycosylation to Aid Macrophage Tissue Invasion.” <i>ELife</i>. eLife Sciences Publications, 2019. <a href=\"https://doi.org/10.7554/elife.41801\">https://doi.org/10.7554/elife.41801</a>.","short":"K. Valosková, J. Bicher, M. Roblek, S. Emtenani, A. György, M. Misova, A. Ratheesh, P. Rodrigues, K. Shkarina, I.S.B. Larsen, S.Y. Vakhrushev, H. Clausen, D.E. Siekhaus, ELife 8 (2019).","ama":"Valosková K, Bicher J, Roblek M, et al. A conserved major facilitator superfamily member orchestrates a subset of O-glycosylation to aid macrophage tissue invasion. <i>eLife</i>. 2019;8. doi:<a href=\"https://doi.org/10.7554/elife.41801\">10.7554/elife.41801</a>","apa":"Valosková, K., Bicher, J., Roblek, M., Emtenani, S., György, A., Misova, M., … Siekhaus, D. E. (2019). A conserved major facilitator superfamily member orchestrates a subset of O-glycosylation to aid macrophage tissue invasion. <i>ELife</i>. eLife Sciences Publications. <a href=\"https://doi.org/10.7554/elife.41801\">https://doi.org/10.7554/elife.41801</a>","mla":"Valosková, Katarina, et al. “A Conserved Major Facilitator Superfamily Member Orchestrates a Subset of O-Glycosylation to Aid Macrophage Tissue Invasion.” <i>ELife</i>, vol. 8, e41801, eLife Sciences Publications, 2019, doi:<a href=\"https://doi.org/10.7554/elife.41801\">10.7554/elife.41801</a>."},"abstract":[{"text":"Aberrant display of the truncated core1 O-glycan T-antigen is a common feature of human cancer cells that correlates with metastasis. Here we show that T-antigen in Drosophila melanogaster macrophages is involved in their developmentally programmed tissue invasion. Higher macrophage T-antigen levels require an atypical major facilitator superfamily (MFS) member that we named Minerva which enables macrophage dissemination and invasion. We characterize for the first time the T and Tn glycoform O-glycoproteome of the Drosophila melanogaster embryo, and determine that Minerva increases the presence of T-antigen on proteins in pathways previously linked to cancer, most strongly on the sulfhydryl oxidase Qsox1 which we show is required for macrophage tissue entry. Minerva’s vertebrate ortholog, MFSD1, rescues the minerva mutant’s migration and T-antigen glycosylation defects. We thus identify a key conserved regulator that orchestrates O-glycosylation on a protein subset to activate a program governing migration steps important for both development and cancer metastasis.","lang":"eng"}],"file_date_updated":"2020-07-14T12:47:23Z","author":[{"full_name":"Valosková, Katarina","last_name":"Valosková","first_name":"Katarina","id":"46F146FC-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Biebl, Julia","id":"3CCBB46E-F248-11E8-B48F-1D18A9856A87","last_name":"Biebl","first_name":"Julia"},{"full_name":"Roblek, Marko","orcid":"0000-0001-9588-1389","last_name":"Roblek","first_name":"Marko","id":"3047D808-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Emtenani, Shamsi","id":"49D32318-F248-11E8-B48F-1D18A9856A87","last_name":"Emtenani","orcid":"0000-0001-6981-6938","first_name":"Shamsi"},{"full_name":"György, Attila","id":"3BCEDBE0-F248-11E8-B48F-1D18A9856A87","last_name":"György","first_name":"Attila","orcid":"0000-0002-1819-198X"},{"id":"495A3C32-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-2427-6856","first_name":"Michaela","last_name":"Misova","full_name":"Misova, Michaela"},{"full_name":"Ratheesh, Aparna","id":"2F064CFE-F248-11E8-B48F-1D18A9856A87","first_name":"Aparna","orcid":"0000-0001-7190-0776","last_name":"Ratheesh"},{"id":"2CE4065A-F248-11E8-B48F-1D18A9856A87","first_name":"Patricia","last_name":"Rodrigues","full_name":"Rodrigues, Patricia"},{"first_name":"Katerina","last_name":"Shkarina","full_name":"Shkarina, Katerina"},{"full_name":"Larsen, Ida Signe Bohse","first_name":"Ida Signe Bohse","last_name":"Larsen"},{"last_name":"Vakhrushev","first_name":"Sergey Y","full_name":"Vakhrushev, Sergey Y"},{"last_name":"Clausen","first_name":"Henrik","full_name":"Clausen, Henrik"},{"full_name":"Siekhaus, Daria E","id":"3D224B9E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8323-8353","first_name":"Daria E","last_name":"Siekhaus"}],"year":"2019","has_accepted_license":"1","publication_status":"published","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","date_created":"2019-03-28T13:37:45Z"},{"title":"Transition to turbulence in particle laden flows","quality_controlled":"1","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1809.06358"}],"oa":1,"language":[{"iso":"eng"}],"doi":"10.1103/PhysRevLett.122.114502","intvolume":"       122","publication_identifier":{"issn":["00319007"],"eissn":["10797114"]},"status":"public","publication":"Physical Review Letters","external_id":{"arxiv":["1809.06358"],"isi":["000461922000006"]},"volume":122,"arxiv":1,"oa_version":"Preprint","article_number":"114502","department":[{"_id":"BjHo"}],"isi":1,"article_processing_charge":"No","issue":"11","related_material":{"record":[{"status":"public","relation":"dissertation_contains","id":"9728"}]},"type":"journal_article","day":"22","publisher":"American Physical Society","citation":{"ieee":"N. Agrawal, G. H. Choueiri, and B. Hof, “Transition to turbulence in particle laden flows,” <i>Physical Review Letters</i>, vol. 122, no. 11. American Physical Society, 2019.","ista":"Agrawal N, Choueiri GH, Hof B. 2019. Transition to turbulence in particle laden flows. Physical Review Letters. 122(11), 114502.","chicago":"Agrawal, Nishchal, George H Choueiri, and Björn Hof. “Transition to Turbulence in Particle Laden Flows.” <i>Physical Review Letters</i>. American Physical Society, 2019. <a href=\"https://doi.org/10.1103/PhysRevLett.122.114502\">https://doi.org/10.1103/PhysRevLett.122.114502</a>.","ama":"Agrawal N, Choueiri GH, Hof B. Transition to turbulence in particle laden flows. <i>Physical Review Letters</i>. 2019;122(11). doi:<a href=\"https://doi.org/10.1103/PhysRevLett.122.114502\">10.1103/PhysRevLett.122.114502</a>","short":"N. Agrawal, G.H. Choueiri, B. Hof, Physical Review Letters 122 (2019).","apa":"Agrawal, N., Choueiri, G. H., &#38; Hof, B. (2019). Transition to turbulence in particle laden flows. <i>Physical Review Letters</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevLett.122.114502\">https://doi.org/10.1103/PhysRevLett.122.114502</a>","mla":"Agrawal, Nishchal, et al. “Transition to Turbulence in Particle Laden Flows.” <i>Physical Review Letters</i>, vol. 122, no. 11, 114502, American Physical Society, 2019, doi:<a href=\"https://doi.org/10.1103/PhysRevLett.122.114502\">10.1103/PhysRevLett.122.114502</a>."},"abstract":[{"lang":"eng","text":"Suspended particles can alter the properties of fluids and in particular also affect the transition fromlaminar to turbulent flow. An earlier study [Mataset al.,Phys. Rev. Lett.90, 014501 (2003)] reported howthe subcritical (i.e., hysteretic) transition to turbulent puffs is affected by the addition of particles. Here weshow that in addition to this known transition, with increasing concentration a supercritical (i.e.,continuous) transition to a globally fluctuating state is found. At the same time the Newtonian-typetransition to puffs is delayed to larger Reynolds numbers. At even higher concentration only the globallyfluctuating state is found. The dynamics of particle laden flows are hence determined by two competinginstabilities that give rise to three flow regimes: Newtonian-type turbulence at low, a particle inducedglobally fluctuating state at high, and a coexistence state at intermediate concentrations."}],"month":"03","date_updated":"2024-03-25T23:30:27Z","scopus_import":"1","date_published":"2019-03-22T00:00:00Z","_id":"6189","publication_status":"published","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2019-03-31T21:59:12Z","year":"2019","author":[{"full_name":"Agrawal, Nishchal","id":"469E6004-F248-11E8-B48F-1D18A9856A87","first_name":"Nishchal","last_name":"Agrawal"},{"full_name":"Choueiri, George H","last_name":"Choueiri","first_name":"George H","id":"448BD5BC-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Hof, Björn","last_name":"Hof","orcid":"0000-0003-2057-2754","first_name":"Björn","id":"3A374330-F248-11E8-B48F-1D18A9856A87"}]},{"intvolume":"        17","language":[{"iso":"eng"}],"doi":"10.1158/1541-7786.MCR-18-0530","page":"783-793","oa":1,"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1158/1541-7786.MCR-18-0530"}],"title":"CCL2 is a vascular permeability factor inducing CCR2-dependent endothelial retraction during lung metastasis","quality_controlled":"1","publication":"Molecular Cancer Research","external_id":{"pmid":["30552233"],"isi":["000460099800012"]},"status":"public","publication_identifier":{"eissn":["15573125"],"issn":["15417786"]},"article_type":"original","oa_version":"Published Version","volume":17,"type":"journal_article","day":"01","isi":1,"issue":"3","article_processing_charge":"No","department":[{"_id":"DaSi"}],"abstract":[{"text":"Increased levels of the chemokine CCL2 in cancer patients are associated with poor prognosis. Experimental evidence suggests that CCL2 correlates with inflammatory monocyte recruitment and induction of vascular activation, but the functionality remains open. Here, we show that endothelial Ccr2 facilitates pulmonary metastasis using an endothelial-specific Ccr2-deficient mouse model (Ccr2ecKO). Similar levels of circulating monocytes and equal leukocyte recruitment to metastatic lesions of Ccr2ecKO and Ccr2fl/fl littermates were observed. The absence of endothelial Ccr2 strongly reduced pulmonary metastasis, while the primary tumor growth was unaffected. Despite a comparable cytokine milieu in Ccr2ecKO and Ccr2fl/fl littermates the absence of vascular permeability induction was observed only in Ccr2ecKO mice. CCL2 stimulation of pulmonary endothelial cells resulted in increased phosphorylation of MLC2, endothelial cell retraction, and vascular leakiness that was blocked by an addition of a CCR2 inhibitor. These data demonstrate that endothelial CCR2 expression is required for tumor cell extravasation and pulmonary metastasis.\r\n\r\nImplications: The findings provide mechanistic insight into how CCL2–CCR2 signaling in endothelial cells promotes their activation through myosin light chain phosphorylation, resulting in endothelial retraction and enhanced tumor cell migration and metastasis.","lang":"eng"}],"citation":{"ieee":"M. Roblek <i>et al.</i>, “CCL2 is a vascular permeability factor inducing CCR2-dependent endothelial retraction during lung metastasis,” <i>Molecular Cancer Research</i>, vol. 17, no. 3. AACR, pp. 783–793, 2019.","ista":"Roblek M, Protsyuk D, Becker PF, Stefanescu C, Gorzelanny C, Glaus Garzon JF, Knopfova L, Heikenwalder M, Luckow B, Schneider SW, Borsig L. 2019. CCL2 is a vascular permeability factor inducing CCR2-dependent endothelial retraction during lung metastasis. Molecular Cancer Research. 17(3), 783–793.","chicago":"Roblek, Marko, Darya Protsyuk, Paul F. Becker, Cristina Stefanescu, Christian Gorzelanny, Jesus F. Glaus Garzon, Lucia Knopfova, et al. “CCL2 Is a Vascular Permeability Factor Inducing CCR2-Dependent Endothelial Retraction during Lung Metastasis.” <i>Molecular Cancer Research</i>. AACR, 2019. <a href=\"https://doi.org/10.1158/1541-7786.MCR-18-0530\">https://doi.org/10.1158/1541-7786.MCR-18-0530</a>.","ama":"Roblek M, Protsyuk D, Becker PF, et al. CCL2 is a vascular permeability factor inducing CCR2-dependent endothelial retraction during lung metastasis. <i>Molecular Cancer Research</i>. 2019;17(3):783-793. doi:<a href=\"https://doi.org/10.1158/1541-7786.MCR-18-0530\">10.1158/1541-7786.MCR-18-0530</a>","short":"M. Roblek, D. Protsyuk, P.F. Becker, C. Stefanescu, C. Gorzelanny, J.F. Glaus Garzon, L. Knopfova, M. Heikenwalder, B. Luckow, S.W. Schneider, L. Borsig, Molecular Cancer Research 17 (2019) 783–793.","apa":"Roblek, M., Protsyuk, D., Becker, P. F., Stefanescu, C., Gorzelanny, C., Glaus Garzon, J. F., … Borsig, L. (2019). CCL2 is a vascular permeability factor inducing CCR2-dependent endothelial retraction during lung metastasis. <i>Molecular Cancer Research</i>. AACR. <a href=\"https://doi.org/10.1158/1541-7786.MCR-18-0530\">https://doi.org/10.1158/1541-7786.MCR-18-0530</a>","mla":"Roblek, Marko, et al. “CCL2 Is a Vascular Permeability Factor Inducing CCR2-Dependent Endothelial Retraction during Lung Metastasis.” <i>Molecular Cancer Research</i>, vol. 17, no. 3, AACR, 2019, pp. 783–93, doi:<a href=\"https://doi.org/10.1158/1541-7786.MCR-18-0530\">10.1158/1541-7786.MCR-18-0530</a>."},"publisher":"AACR","_id":"6190","date_published":"2019-03-01T00:00:00Z","month":"03","scopus_import":"1","date_updated":"2023-08-25T08:57:01Z","publication_status":"published","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","date_created":"2019-03-31T21:59:12Z","author":[{"id":"3047D808-F248-11E8-B48F-1D18A9856A87","last_name":"Roblek","first_name":"Marko","orcid":"0000-0001-9588-1389","full_name":"Roblek, Marko"},{"full_name":"Protsyuk, Darya","last_name":"Protsyuk","first_name":"Darya"},{"last_name":"Becker","first_name":"Paul F.","full_name":"Becker, Paul F."},{"full_name":"Stefanescu, Cristina","first_name":"Cristina","last_name":"Stefanescu"},{"last_name":"Gorzelanny","first_name":"Christian","full_name":"Gorzelanny, Christian"},{"full_name":"Glaus Garzon, Jesus F.","first_name":"Jesus F.","last_name":"Glaus Garzon"},{"first_name":"Lucia","last_name":"Knopfova","full_name":"Knopfova, Lucia"},{"last_name":"Heikenwalder","first_name":"Mathias","full_name":"Heikenwalder, Mathias"},{"last_name":"Luckow","first_name":"Bruno","full_name":"Luckow, Bruno"},{"full_name":"Schneider, Stefan W.","last_name":"Schneider","first_name":"Stefan W."},{"full_name":"Borsig, Lubor","last_name":"Borsig","first_name":"Lubor"}],"year":"2019","pmid":1},{"author":[{"last_name":"Recho","first_name":"Pierre","full_name":"Recho, Pierre"},{"last_name":"Hallou","first_name":"Adrien","full_name":"Hallou, Adrien"},{"full_name":"Hannezo, Edouard B","first_name":"Edouard B","last_name":"Hannezo","orcid":"0000-0001-6005-1561","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87"}],"year":"2019","has_accepted_license":"1","pmid":1,"date_created":"2019-03-31T21:59:13Z","publication_status":"published","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","_id":"6191","date_published":"2019-03-19T00:00:00Z","month":"03","scopus_import":"1","date_updated":"2023-08-25T08:57:30Z","citation":{"mla":"Recho, Pierre, et al. “Theory of Mechanochemical Patterning in Biphasic Biological Tissues.” <i>Proceedings of the National Academy of Sciences of the United States of America</i>, vol. 116, no. 12, National Academy of Sciences, 2019, pp. 5344–49, doi:<a href=\"https://doi.org/10.1073/pnas.1813255116\">10.1073/pnas.1813255116</a>.","apa":"Recho, P., Hallou, A., &#38; Hannezo, E. B. (2019). Theory of mechanochemical patterning in biphasic biological tissues. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.1813255116\">https://doi.org/10.1073/pnas.1813255116</a>","ama":"Recho P, Hallou A, Hannezo EB. Theory of mechanochemical patterning in biphasic biological tissues. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. 2019;116(12):5344-5349. doi:<a href=\"https://doi.org/10.1073/pnas.1813255116\">10.1073/pnas.1813255116</a>","short":"P. Recho, A. Hallou, E.B. Hannezo, Proceedings of the National Academy of Sciences of the United States of America 116 (2019) 5344–5349.","chicago":"Recho, Pierre, Adrien Hallou, and Edouard B Hannezo. “Theory of Mechanochemical Patterning in Biphasic Biological Tissues.” <i>Proceedings of the National Academy of Sciences of the United States of America</i>. National Academy of Sciences, 2019. <a href=\"https://doi.org/10.1073/pnas.1813255116\">https://doi.org/10.1073/pnas.1813255116</a>.","ista":"Recho P, Hallou A, Hannezo EB. 2019. Theory of mechanochemical patterning in biphasic biological tissues. Proceedings of the National Academy of Sciences of the United States of America. 116(12), 5344–5349.","ieee":"P. Recho, A. Hallou, and E. B. Hannezo, “Theory of mechanochemical patterning in biphasic biological tissues,” <i>Proceedings of the National Academy of Sciences of the United States of America</i>, vol. 116, no. 12. National Academy of Sciences, pp. 5344–5349, 2019."},"abstract":[{"text":"The formation of self-organized patterns is key to the morphogenesis of multicellular organisms, although a comprehensive theory of biological pattern formation is still lacking. Here, we propose a minimal model combining tissue mechanics with morphogen turnover and transport to explore routes to patterning. Our active description couples morphogen reaction and diffusion, which impact cell differentiation and tissue mechanics, to a two-phase poroelastic rheology, where one tissue phase consists of a poroelastic cell network and the other one of a permeating extracellular fluid, which provides a feedback by actively transporting morphogens. While this model encompasses previous theories approximating tissues to inert monophasic media, such as Turing’s reaction–diffusion model, it overcomes some of their key limitations permitting pattern formation via any two-species biochemical kinetics due to mechanically induced cross-diffusion flows. Moreover, we describe a qualitatively different advection-driven Keller–Segel instability which allows for the formation of patterns with a single morphogen and whose fundamental mode pattern robustly scales with tissue size. We discuss the potential relevance of these findings for tissue morphogenesis.","lang":"eng"}],"file_date_updated":"2020-07-14T12:47:23Z","publisher":"National Academy of Sciences","day":"19","type":"journal_article","isi":1,"issue":"12","article_processing_charge":"No","related_material":{"link":[{"relation":"supplementary_material","url":"www.pnas.org/lookup/suppl/doi:10.1073/pnas.1813255116/-/DCSupplemental"}]},"department":[{"_id":"EdHa"}],"oa_version":"Published Version","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"volume":116,"ddc":["570"],"publication":"Proceedings of the National Academy of Sciences of the United States of America","external_id":{"pmid":["30819884"],"isi":["000461679000027"]},"status":"public","publication_identifier":{"eissn":["10916490"],"issn":["00278424"]},"project":[{"call_identifier":"FWF","grant_number":"P31639","name":"Active mechano-chemical description of the cell cytoskeleton","_id":"268294B6-B435-11E9-9278-68D0E5697425"}],"intvolume":"       116","file":[{"date_updated":"2020-07-14T12:47:23Z","creator":"dernst","content_type":"application/pdf","file_size":3456045,"file_id":"6193","date_created":"2019-04-03T14:10:30Z","access_level":"open_access","relation":"main_file","file_name":"2019_PNAS_Recho.pdf","checksum":"8b67eee0ea8e5db61583e4d485215258"}],"language":[{"iso":"eng"}],"doi":"10.1073/pnas.1813255116","page":"5344-5349","oa":1,"title":"Theory of mechanochemical patterning in biphasic biological tissues","quality_controlled":"1"},{"file":[{"content_type":"application/pdf","file_size":9045923,"file_id":"7826","date_created":"2020-05-14T09:11:10Z","access_level":"open_access","relation":"main_file","file_name":"2019_Science_Boccara.pdf","checksum":"5e6b16742cde10a560cfaf2130764da1","date_updated":"2020-07-14T12:47:23Z","creator":"dernst"}],"intvolume":"       363","doi":"10.1126/science.aav4837","language":[{"iso":"eng"}],"oa":1,"page":"1443-1447","quality_controlled":"1","title":"The entorhinal cognitive map is attracted to goals","publication":"Science","external_id":{"isi":["000462738000034"]},"ddc":["570"],"status":"public","publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"project":[{"grant_number":"281511","call_identifier":"FP7","name":"Memory-related information processing in neuronal circuits of the hippocampus and entorhinal cortex","_id":"257A4776-B435-11E9-9278-68D0E5697425"},{"grant_number":"665385","call_identifier":"H2020","name":"International IST Doctoral Program","_id":"2564DBCA-B435-11E9-9278-68D0E5697425"}],"article_type":"original","oa_version":"Submitted Version","volume":363,"day":"29","type":"journal_article","related_material":{"link":[{"relation":"press_release","description":"News on IST Homepage","url":"https://ist.ac.at/en/news/grid-cells-create-treasure-map-in-rat-brain/"}],"record":[{"status":"public","id":"6062","relation":"popular_science"},{"relation":"dissertation_contains","id":"11932","status":"public"}]},"issue":"6434","isi":1,"article_processing_charge":"No","department":[{"_id":"JoCs"}],"citation":{"ieee":"C. N. Boccara, M. Nardin, F. Stella, J. O’Neill, and J. L. Csicsvari, “The entorhinal cognitive map is attracted to goals,” <i>Science</i>, vol. 363, no. 6434. American Association for the Advancement of Science, pp. 1443–1447, 2019.","ista":"Boccara CN, Nardin M, Stella F, O’Neill J, Csicsvari JL. 2019. The entorhinal cognitive map is attracted to goals. Science. 363(6434), 1443–1447.","short":"C.N. Boccara, M. Nardin, F. Stella, J. O’Neill, J.L. Csicsvari, Science 363 (2019) 1443–1447.","ama":"Boccara CN, Nardin M, Stella F, O’Neill J, Csicsvari JL. The entorhinal cognitive map is attracted to goals. <i>Science</i>. 2019;363(6434):1443-1447. doi:<a href=\"https://doi.org/10.1126/science.aav4837\">10.1126/science.aav4837</a>","chicago":"Boccara, Charlotte N., Michele Nardin, Federico Stella, Joseph O’Neill, and Jozsef L Csicsvari. “The Entorhinal Cognitive Map Is Attracted to Goals.” <i>Science</i>. American Association for the Advancement of Science, 2019. <a href=\"https://doi.org/10.1126/science.aav4837\">https://doi.org/10.1126/science.aav4837</a>.","mla":"Boccara, Charlotte N., et al. “The Entorhinal Cognitive Map Is Attracted to Goals.” <i>Science</i>, vol. 363, no. 6434, American Association for the Advancement of Science, 2019, pp. 1443–47, doi:<a href=\"https://doi.org/10.1126/science.aav4837\">10.1126/science.aav4837</a>.","apa":"Boccara, C. N., Nardin, M., Stella, F., O’Neill, J., &#38; Csicsvari, J. L. (2019). The entorhinal cognitive map is attracted to goals. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.aav4837\">https://doi.org/10.1126/science.aav4837</a>"},"abstract":[{"text":"Grid cells with their rigid hexagonal firing fields are thought to provide an invariant metric to the hippocampal cognitive map, yet environmental geometrical features have recently been shown to distort the grid structure. Given that the hippocampal role goes beyond space, we tested the influence of nonspatial information on the grid organization. We trained rats to daily learn three new reward locations on a cheeseboard maze while recording from the medial entorhinal cortex and the hippocampal CA1 region. Many grid fields moved toward goal location, leading to long-lasting deformations of the entorhinal map. Therefore, distortions in the grid structure contribute to goal representation during both learning and recall, which demonstrates that grid cells participate in mnemonic coding and do not merely provide a simple metric of space.","lang":"eng"}],"file_date_updated":"2020-07-14T12:47:23Z","publisher":"American Association for the Advancement of Science","_id":"6194","date_published":"2019-03-29T00:00:00Z","ec_funded":1,"scopus_import":"1","date_updated":"2024-03-25T23:30:09Z","month":"03","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","date_created":"2019-04-04T08:39:30Z","publication_status":"published","author":[{"full_name":"Boccara, Charlotte N.","id":"3FC06552-F248-11E8-B48F-1D18A9856A87","first_name":"Charlotte N.","orcid":"0000-0001-7237-5109","last_name":"Boccara"},{"full_name":"Nardin, Michele","first_name":"Michele","orcid":"0000-0001-8849-6570","last_name":"Nardin","id":"30BD0376-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Stella","orcid":"0000-0001-9439-3148","first_name":"Federico","id":"39AF1E74-F248-11E8-B48F-1D18A9856A87","full_name":"Stella, Federico"},{"last_name":"O'Neill","first_name":"Joseph","id":"426376DC-F248-11E8-B48F-1D18A9856A87","full_name":"O'Neill, Joseph"},{"full_name":"Csicsvari, Jozsef L","id":"3FA14672-F248-11E8-B48F-1D18A9856A87","last_name":"Csicsvari","first_name":"Jozsef L","orcid":"0000-0002-5193-4036"}],"has_accepted_license":"1","year":"2019"},{"volume":867,"oa_version":"Preprint","arxiv":1,"related_material":{"record":[{"relation":"dissertation_contains","id":"7258","status":"public"}],"link":[{"relation":"supplementary_material","url":"https://doi.org/10.1017/jfm.2019.191"}]},"article_processing_charge":"No","isi":1,"day":"25","type":"journal_article","department":[{"_id":"BjHo"}],"doi":"10.1017/jfm.2019.191","language":[{"iso":"eng"}],"intvolume":"       867","quality_controlled":"1","title":"Relaminarising pipe flow by wall movement","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1807.05357"}],"oa":1,"page":"934-948","publication":"Journal of Fluid Mechanics","external_id":{"arxiv":["1807.05357"],"isi":["000462606100001"]},"project":[{"name":"Decoding the complexity of turbulence at its origin","_id":"25152F3A-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","grant_number":"306589"},{"grant_number":"737549","call_identifier":"H2020","name":"Eliminating turbulence in oil pipelines","_id":"25104D44-B435-11E9-9278-68D0E5697425"}],"status":"public","publication_identifier":{"issn":["00221120"],"eissn":["14697645"]},"date_created":"2019-04-07T21:59:14Z","publication_status":"published","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","year":"2019","author":[{"full_name":"Scarselli, Davide","first_name":"Davide","last_name":"Scarselli","orcid":"0000-0001-5227-4271","id":"40315C30-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Kühnen","orcid":"0000-0003-4312-0179","first_name":"Jakob","id":"3A47AE32-F248-11E8-B48F-1D18A9856A87","full_name":"Kühnen, Jakob"},{"full_name":"Hof, Björn","first_name":"Björn","orcid":"0000-0003-2057-2754","last_name":"Hof","id":"3A374330-F248-11E8-B48F-1D18A9856A87"}],"abstract":[{"lang":"eng","text":"Following  the  recent  observation  that  turbulent  pipe  flow  can  be  relaminarised  bya  relatively  simple  modification  of  the  mean  velocity  profile,  we  here  carry  out  aquantitative  experimental  investigation  of  this  phenomenon.  Our  study  confirms  thata  flat  velocity  profile  leads  to  a  collapse  of  turbulence  and  in  order  to  achieve  theblunted  profile  shape,  we  employ  a  moving  pipe  segment  that  is  briefly  and  rapidlyshifted  in  the  streamwise  direction.  The  relaminarisation  threshold  and  the  minimumshift  length  and  speeds  are  determined  as  a  function  of  Reynolds  number.  Althoughturbulence  is  still  active  after  the  acceleration  phase,  the  modulated  profile  possessesa  severely  decreased  lift-up  potential  as  measured  by  transient  growth.  As  shown,this  results  in  an  exponential  decay  of  fluctuations  and  the  flow  relaminarises.  Whilethis  method  can  be  easily  applied  at  low  to  moderate  flow  speeds,  the  minimumstreamwise  length  over  which  the  acceleration  needs  to  act  increases  linearly  with  theReynolds  number."}],"citation":{"ieee":"D. Scarselli, J. Kühnen, and B. Hof, “Relaminarising pipe flow by wall movement,” <i>Journal of Fluid Mechanics</i>, vol. 867. Cambridge University Press, pp. 934–948, 2019.","ista":"Scarselli D, Kühnen J, Hof B. 2019. Relaminarising pipe flow by wall movement. Journal of Fluid Mechanics. 867, 934–948.","chicago":"Scarselli, Davide, Jakob Kühnen, and Björn Hof. “Relaminarising Pipe Flow by Wall Movement.” <i>Journal of Fluid Mechanics</i>. Cambridge University Press, 2019. <a href=\"https://doi.org/10.1017/jfm.2019.191\">https://doi.org/10.1017/jfm.2019.191</a>.","short":"D. Scarselli, J. Kühnen, B. Hof, Journal of Fluid Mechanics 867 (2019) 934–948.","ama":"Scarselli D, Kühnen J, Hof B. Relaminarising pipe flow by wall movement. <i>Journal of Fluid Mechanics</i>. 2019;867:934-948. doi:<a href=\"https://doi.org/10.1017/jfm.2019.191\">10.1017/jfm.2019.191</a>","apa":"Scarselli, D., Kühnen, J., &#38; Hof, B. (2019). Relaminarising pipe flow by wall movement. <i>Journal of Fluid Mechanics</i>. Cambridge University Press. <a href=\"https://doi.org/10.1017/jfm.2019.191\">https://doi.org/10.1017/jfm.2019.191</a>","mla":"Scarselli, Davide, et al. “Relaminarising Pipe Flow by Wall Movement.” <i>Journal of Fluid Mechanics</i>, vol. 867, Cambridge University Press, 2019, pp. 934–48, doi:<a href=\"https://doi.org/10.1017/jfm.2019.191\">10.1017/jfm.2019.191</a>."},"publisher":"Cambridge University Press","date_published":"2019-05-25T00:00:00Z","ec_funded":1,"_id":"6228","date_updated":"2024-03-25T23:30:20Z","scopus_import":"1","month":"05"},{"publication_identifier":{"eissn":["2050084X"]},"status":"public","publication":"eLife","external_id":{"isi":["000461988300001"]},"ddc":["570"],"oa":1,"quality_controlled":"1","title":"Why structure matters","file":[{"date_updated":"2020-07-14T12:47:24Z","creator":"dernst","file_id":"6293","date_created":"2019-04-11T11:43:38Z","content_type":"application/pdf","file_size":298466,"checksum":"130d7544b57df4a6787e1263c2d7ea43","file_name":"2019_eLife_Barton.pdf","relation":"main_file","access_level":"open_access"}],"intvolume":"         8","doi":"10.7554/eLife.45380","language":[{"iso":"eng"}],"department":[{"_id":"NiBa"}],"day":"21","type":"journal_article","related_material":{"link":[{"url":"https://ist.ac.at/en/news/body-height-bmi-disease-risk-co/","relation":"press_release","description":"News on IST Homepage"}]},"isi":1,"article_processing_charge":"No","article_number":"e45380","oa_version":"Published Version","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"volume":8,"date_updated":"2023-08-25T08:59:38Z","scopus_import":"1","month":"03","_id":"6230","date_published":"2019-03-21T00:00:00Z","publisher":"eLife Sciences Publications","abstract":[{"text":"Great care is needed when interpreting claims about the genetic basis of human variation based on data from genome-wide association studies.","lang":"eng"}],"citation":{"chicago":"Barton, Nicholas H, Joachim Hermisson, and Magnus Nordborg. “Why Structure Matters.” <i>ELife</i>. eLife Sciences Publications, 2019. <a href=\"https://doi.org/10.7554/eLife.45380\">https://doi.org/10.7554/eLife.45380</a>.","short":"N.H. Barton, J. Hermisson, M. Nordborg, ELife 8 (2019).","ama":"Barton NH, Hermisson J, Nordborg M. Why structure matters. <i>eLife</i>. 2019;8. doi:<a href=\"https://doi.org/10.7554/eLife.45380\">10.7554/eLife.45380</a>","apa":"Barton, N. H., Hermisson, J., &#38; Nordborg, M. (2019). Why structure matters. <i>ELife</i>. eLife Sciences Publications. <a href=\"https://doi.org/10.7554/eLife.45380\">https://doi.org/10.7554/eLife.45380</a>","mla":"Barton, Nicholas H., et al. “Why Structure Matters.” <i>ELife</i>, vol. 8, e45380, eLife Sciences Publications, 2019, doi:<a href=\"https://doi.org/10.7554/eLife.45380\">10.7554/eLife.45380</a>.","ieee":"N. H. Barton, J. Hermisson, and M. Nordborg, “Why structure matters,” <i>eLife</i>, vol. 8. eLife Sciences Publications, 2019.","ista":"Barton NH, Hermisson J, Nordborg M. 2019. Why structure matters. eLife. 8, e45380."},"file_date_updated":"2020-07-14T12:47:24Z","author":[{"last_name":"Barton","orcid":"0000-0002-8548-5240","first_name":"Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","full_name":"Barton, Nicholas H"},{"full_name":"Hermisson, Joachim","last_name":"Hermisson","first_name":"Joachim"},{"full_name":"Nordborg, Magnus","last_name":"Nordborg","first_name":"Magnus"}],"has_accepted_license":"1","year":"2019","date_created":"2019-04-07T21:59:15Z","publication_status":"published","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8"},{"date_created":"2019-04-07T21:59:15Z","publication_status":"published","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","author":[{"id":"44ECEDF2-F248-11E8-B48F-1D18A9856A87","last_name":"Gerencser","first_name":"Mate","full_name":"Gerencser, Mate"}],"year":"2019","abstract":[{"text":"The boundary behaviour of solutions of stochastic PDEs with Dirichlet boundary conditions can be surprisingly—and in a sense, arbitrarily—bad: as shown by Krylov[ SIAM J. Math. Anal.34(2003) 1167–1182], for any α>0 one can find a simple 1-dimensional constant coefficient linear equation whose solution at the boundary is not α-Hölder continuous.We obtain a positive counterpart of this: under some mild regularity assumptions on the coefficients, solutions of semilinear SPDEs on C1 domains are proved to be α-Hölder continuous up to the boundary with some α>0.","lang":"eng"}],"citation":{"apa":"Gerencser, M. (2019). Boundary regularity of stochastic PDEs. <i>Annals of Probability</i>. Institute of Mathematical Statistics. <a href=\"https://doi.org/10.1214/18-AOP1272\">https://doi.org/10.1214/18-AOP1272</a>","mla":"Gerencser, Mate. “Boundary Regularity of Stochastic PDEs.” <i>Annals of Probability</i>, vol. 47, no. 2, Institute of Mathematical Statistics, 2019, pp. 804–34, doi:<a href=\"https://doi.org/10.1214/18-AOP1272\">10.1214/18-AOP1272</a>.","chicago":"Gerencser, Mate. “Boundary Regularity of Stochastic PDEs.” <i>Annals of Probability</i>. Institute of Mathematical Statistics, 2019. <a href=\"https://doi.org/10.1214/18-AOP1272\">https://doi.org/10.1214/18-AOP1272</a>.","short":"M. Gerencser, Annals of Probability 47 (2019) 804–834.","ama":"Gerencser M. Boundary regularity of stochastic PDEs. <i>Annals of Probability</i>. 2019;47(2):804-834. doi:<a href=\"https://doi.org/10.1214/18-AOP1272\">10.1214/18-AOP1272</a>","ista":"Gerencser M. 2019. Boundary regularity of stochastic PDEs. Annals of Probability. 47(2), 804–834.","ieee":"M. Gerencser, “Boundary regularity of stochastic PDEs,” <i>Annals of Probability</i>, vol. 47, no. 2. Institute of Mathematical Statistics, pp. 804–834, 2019."},"publisher":"Institute of Mathematical Statistics","_id":"6232","date_published":"2019-03-01T00:00:00Z","date_updated":"2023-08-25T08:59:11Z","scopus_import":"1","month":"03","arxiv":1,"oa_version":"Preprint","volume":47,"type":"journal_article","day":"01","issue":"2","article_processing_charge":"No","isi":1,"department":[{"_id":"JaMa"}],"intvolume":"        47","doi":"10.1214/18-AOP1272","language":[{"iso":"eng"}],"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1705.05364"}],"oa":1,"page":"804-834","quality_controlled":"1","title":"Boundary regularity of stochastic PDEs","external_id":{"isi":["000459681900005"],"arxiv":["1705.05364"]},"publication":"Annals of Probability","publication_identifier":{"issn":["00911798"]},"status":"public"},{"date_created":"2019-04-08T14:05:04Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_status":"published","year":"2019","author":[{"full_name":"Alt, Johannes","id":"36D3D8B6-F248-11E8-B48F-1D18A9856A87","first_name":"Johannes","last_name":"Alt"},{"full_name":"Erdös, László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","first_name":"László","orcid":"0000-0001-5366-9603","last_name":"Erdös"},{"first_name":"Torben H","orcid":"0000-0002-4821-3297","last_name":"Krüger","id":"3020C786-F248-11E8-B48F-1D18A9856A87","full_name":"Krüger, Torben H"},{"full_name":"Nemish, Yuriy","id":"4D902E6A-F248-11E8-B48F-1D18A9856A87","last_name":"Nemish","first_name":"Yuriy","orcid":"0000-0002-7327-856X"}],"citation":{"ista":"Alt J, Erdös L, Krüger TH, Nemish Y. 2019. Location of the spectrum of Kronecker random matrices. Annales de l’institut Henri Poincare. 55(2), 661–696.","ieee":"J. Alt, L. Erdös, T. H. Krüger, and Y. Nemish, “Location of the spectrum of Kronecker random matrices,” <i>Annales de l’institut Henri Poincare</i>, vol. 55, no. 2. Institut Henri Poincaré, pp. 661–696, 2019.","mla":"Alt, Johannes, et al. “Location of the Spectrum of Kronecker Random Matrices.” <i>Annales de l’institut Henri Poincare</i>, vol. 55, no. 2, Institut Henri Poincaré, 2019, pp. 661–96, doi:<a href=\"https://doi.org/10.1214/18-AIHP894\">10.1214/18-AIHP894</a>.","apa":"Alt, J., Erdös, L., Krüger, T. H., &#38; Nemish, Y. (2019). Location of the spectrum of Kronecker random matrices. <i>Annales de l’institut Henri Poincare</i>. Institut Henri Poincaré. <a href=\"https://doi.org/10.1214/18-AIHP894\">https://doi.org/10.1214/18-AIHP894</a>","ama":"Alt J, Erdös L, Krüger TH, Nemish Y. Location of the spectrum of Kronecker random matrices. <i>Annales de l’institut Henri Poincare</i>. 2019;55(2):661-696. doi:<a href=\"https://doi.org/10.1214/18-AIHP894\">10.1214/18-AIHP894</a>","short":"J. Alt, L. Erdös, T.H. Krüger, Y. Nemish, Annales de l’institut Henri Poincare 55 (2019) 661–696.","chicago":"Alt, Johannes, László Erdös, Torben H Krüger, and Yuriy Nemish. “Location of the Spectrum of Kronecker Random Matrices.” <i>Annales de l’institut Henri Poincare</i>. Institut Henri Poincaré, 2019. <a href=\"https://doi.org/10.1214/18-AIHP894\">https://doi.org/10.1214/18-AIHP894</a>."},"abstract":[{"text":"For a general class of large non-Hermitian random block matrices X we prove that there are no eigenvalues away from a deterministic set with very high probability. This set is obtained from the Dyson equation of the Hermitization of X as the self-consistent approximation of the pseudospectrum. We demonstrate that the analysis of the matrix Dyson equation from (Probab. Theory Related Fields (2018)) offers a unified treatment of many structured matrix ensembles.","lang":"eng"}],"publisher":"Institut Henri Poincaré","ec_funded":1,"date_published":"2019-05-01T00:00:00Z","_id":"6240","month":"05","date_updated":"2023-10-17T12:20:20Z","scopus_import":"1","volume":55,"oa_version":"Preprint","arxiv":1,"issue":"2","isi":1,"article_processing_charge":"No","related_material":{"record":[{"status":"public","id":"149","relation":"dissertation_contains"}]},"day":"01","type":"journal_article","department":[{"_id":"LaEr"}],"language":[{"iso":"eng"}],"doi":"10.1214/18-AIHP894","intvolume":"        55","title":"Location of the spectrum of Kronecker random matrices","quality_controlled":"1","page":"661-696","oa":1,"main_file_link":[{"url":"https://arxiv.org/abs/1706.08343","open_access":"1"}],"publication":"Annales de l'institut Henri Poincare","external_id":{"isi":["000467793600003"],"arxiv":["1706.08343"]},"project":[{"call_identifier":"FP7","grant_number":"338804","_id":"258DCDE6-B435-11E9-9278-68D0E5697425","name":"Random matrices, universality and disordered quantum systems"}],"status":"public","publication_identifier":{"issn":["0246-0203"]}},{"abstract":[{"text":"The plant hormone auxin has crucial roles in almost all aspects of plant growth and development. Concentrations of auxin vary across different tissues, mediating distinct developmental outcomes and contributing to the functional diversity of auxin. However, the mechanisms that underlie these activities are poorly understood. Here we identify an auxin signalling mechanism, which acts in parallel to the canonical auxin pathway based on the transport inhibitor response1 (TIR1) and other auxin receptor F-box (AFB) family proteins (TIR1/AFB receptors)1,2, that translates levels of cellular auxin to mediate differential growth during apical-hook development. This signalling mechanism operates at the concave side of the apical hook, and involves auxin-mediated C-terminal cleavage of transmembrane kinase 1 (TMK1). The cytosolic and nucleus-translocated C terminus of TMK1 specifically interacts with and phosphorylates two non-canonical transcriptional repressors of the auxin or indole-3-acetic acid (Aux/IAA) family (IAA32 and IAA34), thereby regulating ARF transcription factors. In contrast to the degradation of Aux/IAA transcriptional repressors in the canonical pathway, the newly identified mechanism stabilizes the non-canonical IAA32 and IAA34 transcriptional repressors to regulate gene expression and ultimately inhibit growth. The auxin–TMK1 signalling pathway originates at the cell surface, is triggered by high levels of auxin and shares a partially overlapping set of transcription factors with the TIR1/AFB signalling pathway. This allows distinct interpretations of different concentrations of cellular auxin, and thus enables this versatile signalling molecule to mediate complex developmental outcomes.","lang":"eng"}],"file_date_updated":"2020-11-13T07:37:41Z","citation":{"chicago":"Cao, Min, Rong Chen, Pan Li, Yongqiang Yu, Rui Zheng, Danfeng Ge, Wei Zheng, et al. “TMK1-Mediated Auxin Signalling Regulates Differential Growth of the Apical Hook.” <i>Nature</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s41586-019-1069-7\">https://doi.org/10.1038/s41586-019-1069-7</a>.","short":"M. Cao, R. Chen, P. Li, Y. Yu, R. Zheng, D. Ge, W. Zheng, X. Wang, Y. Gu, Z. Gelová, J. Friml, H. Zhang, R. Liu, J. He, T. Xu, Nature 568 (2019) 240–243.","ama":"Cao M, Chen R, Li P, et al. TMK1-mediated auxin signalling regulates differential growth of the apical hook. <i>Nature</i>. 2019;568:240-243. doi:<a href=\"https://doi.org/10.1038/s41586-019-1069-7\">10.1038/s41586-019-1069-7</a>","apa":"Cao, M., Chen, R., Li, P., Yu, Y., Zheng, R., Ge, D., … Xu, T. (2019). TMK1-mediated auxin signalling regulates differential growth of the apical hook. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-019-1069-7\">https://doi.org/10.1038/s41586-019-1069-7</a>","mla":"Cao, Min, et al. “TMK1-Mediated Auxin Signalling Regulates Differential Growth of the Apical Hook.” <i>Nature</i>, vol. 568, Springer Nature, 2019, pp. 240–43, doi:<a href=\"https://doi.org/10.1038/s41586-019-1069-7\">10.1038/s41586-019-1069-7</a>.","ieee":"M. Cao <i>et al.</i>, “TMK1-mediated auxin signalling regulates differential growth of the apical hook,” <i>Nature</i>, vol. 568. Springer Nature, pp. 240–243, 2019.","ista":"Cao M, Chen R, Li P, Yu Y, Zheng R, Ge D, Zheng W, Wang X, Gu Y, Gelová Z, Friml J, Zhang H, Liu R, He J, Xu T. 2019. TMK1-mediated auxin signalling regulates differential growth of the apical hook. Nature. 568, 240–243."},"publisher":"Springer Nature","_id":"6259","ec_funded":1,"date_published":"2019-04-11T00:00:00Z","month":"04","scopus_import":"1","date_updated":"2023-09-05T14:58:41Z","publication_status":"published","date_created":"2019-04-09T08:37:05Z","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","author":[{"last_name":"Cao","first_name":"Min","full_name":"Cao, Min"},{"last_name":"Chen","first_name":"Rong","full_name":"Chen, Rong"},{"first_name":"Pan","last_name":"Li","full_name":"Li, Pan"},{"last_name":"Yu","first_name":"Yongqiang","full_name":"Yu, Yongqiang"},{"full_name":"Zheng, Rui","last_name":"Zheng","first_name":"Rui"},{"full_name":"Ge, Danfeng","first_name":"Danfeng","last_name":"Ge"},{"last_name":"Zheng","first_name":"Wei","full_name":"Zheng, Wei"},{"first_name":"Xuhui","last_name":"Wang","full_name":"Wang, Xuhui"},{"full_name":"Gu, Yangtao","last_name":"Gu","first_name":"Yangtao"},{"full_name":"Gelová, Zuzana","orcid":"0000-0003-4783-1752","first_name":"Zuzana","last_name":"Gelová","id":"0AE74790-0E0B-11E9-ABC7-1ACFE5697425"},{"last_name":"Friml","orcid":"0000-0002-8302-7596","first_name":"Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87","full_name":"Friml, Jiří"},{"last_name":"Zhang","first_name":"Heng","full_name":"Zhang, Heng"},{"full_name":"Liu, Renyi","first_name":"Renyi","last_name":"Liu"},{"first_name":"Jun","last_name":"He","full_name":"He, Jun"},{"full_name":"Xu, Tongda","last_name":"Xu","first_name":"Tongda"}],"year":"2019","has_accepted_license":"1","pmid":1,"intvolume":"       568","file":[{"file_id":"8751","date_created":"2020-11-13T07:37:41Z","file_size":4321328,"content_type":"application/pdf","checksum":"6b84ab602a34382cf0340a37a1378c75","file_name":"2019_Nature _Cao_accepted.pdf","success":1,"relation":"main_file","access_level":"open_access","date_updated":"2020-11-13T07:37:41Z","creator":"dernst"}],"language":[{"iso":"eng"}],"doi":"10.1038/s41586-019-1069-7","page":"240-243","oa":1,"title":"TMK1-mediated auxin signalling regulates differential growth of the apical hook","quality_controlled":"1","ddc":["580"],"publication":"Nature","external_id":{"pmid":["30944466"],"isi":["000464412700050"]},"status":"public","publication_identifier":{"issn":["0028-0836"],"eissn":["1476-4687"]},"project":[{"grant_number":"742985","call_identifier":"H2020","_id":"261099A6-B435-11E9-9278-68D0E5697425","name":"Tracing Evolution of Auxin Transport and Polarity in Plants"}],"article_type":"original","oa_version":"Submitted Version","volume":568,"type":"journal_article","day":"11","article_processing_charge":"No","isi":1,"related_material":{"link":[{"url":"https://ist.ac.at/en/news/newly-discovered-mechanism-of-plant-hormone-auxin-acts-the-opposite-way/","description":"News on IST Homepage","relation":"press_release"}]},"department":[{"_id":"JiFr"}]},{"date_created":"2019-04-09T08:38:20Z","publication_status":"published","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","pmid":1,"year":"2019","author":[{"last_name":"Oochi","first_name":"A","full_name":"Oochi, A"},{"last_name":"Hajny","first_name":"Jakub","orcid":"0000-0003-2140-7195","id":"4800CC20-F248-11E8-B48F-1D18A9856A87","full_name":"Hajny, Jakub"},{"full_name":"Fukui, K","last_name":"Fukui","first_name":"K"},{"full_name":"Nakao, Y","last_name":"Nakao","first_name":"Y"},{"full_name":"Gallei, Michelle C","id":"35A03822-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-1286-7368","first_name":"Michelle C","last_name":"Gallei"},{"first_name":"M","last_name":"Quareshy","full_name":"Quareshy, M"},{"full_name":"Takahashi, K","last_name":"Takahashi","first_name":"K"},{"first_name":"T","last_name":"Kinoshita","full_name":"Kinoshita, T"},{"first_name":"SR","last_name":"Harborough","full_name":"Harborough, SR"},{"full_name":"Kepinski, S","last_name":"Kepinski","first_name":"S"},{"full_name":"Kasahara, H","last_name":"Kasahara","first_name":"H"},{"full_name":"Napier, RM","last_name":"Napier","first_name":"RM"},{"full_name":"Friml, Jiří","orcid":"0000-0002-8302-7596","first_name":"Jiří","last_name":"Friml","id":"4159519E-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Hayashi","first_name":"KI","full_name":"Hayashi, KI"}],"publisher":"ASPB","abstract":[{"text":"Polar auxin transport plays a pivotal role in plant growth and development. PIN auxin efflux carriers regulate directional auxin movement by establishing local auxin maxima, minima, and gradients that drive multiple developmental processes and responses to environmental signals. Auxin has been proposed to modulate its own transport by regulating subcellular PIN trafficking via processes such as clathrin-mediated PIN endocytosis and constitutive recycling. Here, we further investigated the mechanisms by which auxin affects PIN trafficking by screening auxin analogs and identified pinstatic acid (PISA) as a positive modulator of polar auxin transport in Arabidopsis thaliana. PISA had an auxin-like effect on hypocotyl elongation and adventitious root formation via positive regulation of auxin transport. PISA did not activate SCFTIR1/AFB signaling and yet induced PIN accumulation at the cell surface by inhibiting PIN internalization from the plasma membrane. This work demonstrates PISA to be a promising chemical tool to dissect the regulatory mechanisms behind subcellular PIN trafficking and auxin transport.","lang":"eng"}],"citation":{"ieee":"A. Oochi <i>et al.</i>, “Pinstatic acid promotes auxin transport by inhibiting PIN internalization,” <i>Plant Physiology</i>, vol. 180, no. 2. ASPB, pp. 1152–1165, 2019.","ista":"Oochi A, Hajny J, Fukui K, Nakao Y, Gallei MC, Quareshy M, Takahashi K, Kinoshita T, Harborough S, Kepinski S, Kasahara H, Napier R, Friml J, Hayashi K. 2019. Pinstatic acid promotes auxin transport by inhibiting PIN internalization. Plant Physiology. 180(2), 1152–1165.","chicago":"Oochi, A, Jakub Hajny, K Fukui, Y Nakao, Michelle C Gallei, M Quareshy, K Takahashi, et al. “Pinstatic Acid Promotes Auxin Transport by Inhibiting PIN Internalization.” <i>Plant Physiology</i>. ASPB, 2019. <a href=\"https://doi.org/10.1104/pp.19.00201\">https://doi.org/10.1104/pp.19.00201</a>.","ama":"Oochi A, Hajny J, Fukui K, et al. Pinstatic acid promotes auxin transport by inhibiting PIN internalization. <i>Plant Physiology</i>. 2019;180(2):1152-1165. doi:<a href=\"https://doi.org/10.1104/pp.19.00201\">10.1104/pp.19.00201</a>","short":"A. Oochi, J. Hajny, K. Fukui, Y. Nakao, M.C. Gallei, M. Quareshy, K. Takahashi, T. Kinoshita, S. Harborough, S. Kepinski, H. Kasahara, R. Napier, J. Friml, K. Hayashi, Plant Physiology 180 (2019) 1152–1165.","apa":"Oochi, A., Hajny, J., Fukui, K., Nakao, Y., Gallei, M. C., Quareshy, M., … Hayashi, K. (2019). Pinstatic acid promotes auxin transport by inhibiting PIN internalization. <i>Plant Physiology</i>. ASPB. <a href=\"https://doi.org/10.1104/pp.19.00201\">https://doi.org/10.1104/pp.19.00201</a>","mla":"Oochi, A., et al. “Pinstatic Acid Promotes Auxin Transport by Inhibiting PIN Internalization.” <i>Plant Physiology</i>, vol. 180, no. 2, ASPB, 2019, pp. 1152–65, doi:<a href=\"https://doi.org/10.1104/pp.19.00201\">10.1104/pp.19.00201</a>."},"acknowledgement":"We thank Dr. H. Fukaki (University of Kobe), Dr. R. Offringa (Leiden University), Dr. Jianwei Pan (Zhejiang Normal University), and Dr. M. Estelle (University of California at San Diego) for providing mutants and transgenic line seeds.\r\nThis work was supported by the Ministry of Education, Culture, Sports, Science, and Technology (Grant-in-Aid for Scientific Research no. JP25114518 to K.H.), the Biotechnology and Biological Sciences Research Council (award no. BB/L009366/1 to R.N. and S.K.), and the European Union’s Horizon2020 program (European Research Council grant agreement no. 742985 to J.F.).","month":"06","scopus_import":"1","date_updated":"2024-03-25T23:30:21Z","ec_funded":1,"date_published":"2019-06-01T00:00:00Z","_id":"6260","volume":180,"oa_version":"Published Version","article_type":"original","department":[{"_id":"JiFr"}],"isi":1,"article_processing_charge":"No","issue":"2","related_material":{"record":[{"status":"public","relation":"dissertation_contains","id":"11626"},{"id":"8822","relation":"dissertation_contains","status":"public"}]},"type":"journal_article","day":"01","title":"Pinstatic acid promotes auxin transport by inhibiting PIN internalization","quality_controlled":"1","page":"1152-1165","oa":1,"main_file_link":[{"url":"https://doi.org/10.1104/pp.19.00201","open_access":"1"}],"language":[{"iso":"eng"}],"doi":"10.1104/pp.19.00201","intvolume":"       180","project":[{"_id":"261099A6-B435-11E9-9278-68D0E5697425","name":"Tracing Evolution of Auxin Transport and Polarity in Plants","call_identifier":"H2020","grant_number":"742985"}],"publication_identifier":{"eissn":["1532-2548"],"issn":["0032-0889"]},"status":"public","publication":"Plant Physiology","external_id":{"isi":["000470086100045"],"pmid":["30936248"]}},{"publication_status":"published","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","date_created":"2019-04-09T08:46:17Z","pmid":1,"author":[{"full_name":"Wang, Y","last_name":"Wang","first_name":"Y"},{"full_name":"Gong, Z","first_name":"Z","last_name":"Gong"},{"full_name":"Friml, Jiří","orcid":"0000-0002-8302-7596","first_name":"Jiří","last_name":"Friml","id":"4159519E-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Zhang, J","last_name":"Zhang","first_name":"J"}],"year":"2019","publisher":"ASPB","citation":{"ieee":"Y. Wang, Z. Gong, J. Friml, and J. Zhang, “Nitrate modulates the differentiation of root distal stem cells,” <i>Plant Physiology</i>, vol. 180, no. 1. ASPB, pp. 22–25, 2019.","ista":"Wang Y, Gong Z, Friml J, Zhang J. 2019. Nitrate modulates the differentiation of root distal stem cells. Plant Physiology. 180(1), 22–25.","chicago":"Wang, Y, Z Gong, Jiří Friml, and J Zhang. “Nitrate Modulates the Differentiation of Root Distal Stem Cells.” <i>Plant Physiology</i>. ASPB, 2019. <a href=\"https://doi.org/10.1104/pp.18.01305\">https://doi.org/10.1104/pp.18.01305</a>.","short":"Y. Wang, Z. Gong, J. Friml, J. Zhang, Plant Physiology 180 (2019) 22–25.","ama":"Wang Y, Gong Z, Friml J, Zhang J. Nitrate modulates the differentiation of root distal stem cells. <i>Plant Physiology</i>. 2019;180(1):22-25. doi:<a href=\"https://doi.org/10.1104/pp.18.01305\">10.1104/pp.18.01305</a>","apa":"Wang, Y., Gong, Z., Friml, J., &#38; Zhang, J. (2019). Nitrate modulates the differentiation of root distal stem cells. <i>Plant Physiology</i>. ASPB. <a href=\"https://doi.org/10.1104/pp.18.01305\">https://doi.org/10.1104/pp.18.01305</a>","mla":"Wang, Y., et al. “Nitrate Modulates the Differentiation of Root Distal Stem Cells.” <i>Plant Physiology</i>, vol. 180, no. 1, ASPB, 2019, pp. 22–25, doi:<a href=\"https://doi.org/10.1104/pp.18.01305\">10.1104/pp.18.01305</a>."},"abstract":[{"text":"Nitrate regulation of root stem cell activity is auxin-dependent.","lang":"eng"}],"date_updated":"2023-08-25T10:10:23Z","scopus_import":"1","month":"05","_id":"6261","date_published":"2019-05-01T00:00:00Z","oa_version":"Published Version","volume":180,"article_type":"letter_note","department":[{"_id":"JiFr"}],"day":"01","type":"journal_article","isi":1,"issue":"1","article_processing_charge":"No","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1104/pp.18.01305"}],"oa":1,"page":"22-25","quality_controlled":"1","title":"Nitrate modulates the differentiation of root distal stem cells","intvolume":"       180","doi":"10.1104/pp.18.01305","language":[{"iso":"eng"}],"publication_identifier":{"eissn":["1532-2548"],"issn":["0032-0889"]},"status":"public","external_id":{"pmid":["30787134"],"isi":["000466860800010"]},"publication":"Plant Physiology"},{"pmid":1,"author":[{"last_name":"Rakusová","first_name":"Hana","full_name":"Rakusová, Hana"},{"full_name":"Han, Huibin","id":"31435098-F248-11E8-B48F-1D18A9856A87","first_name":"Huibin","last_name":"Han"},{"first_name":"Petr","last_name":"Valošek","id":"3CDB6F94-F248-11E8-B48F-1D18A9856A87","full_name":"Valošek, Petr"},{"id":"4159519E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8302-7596","first_name":"Jiří","last_name":"Friml","full_name":"Friml, Jiří"}],"has_accepted_license":"1","year":"2019","date_created":"2019-04-09T08:46:44Z","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","publication_status":"published","scopus_import":"1","date_updated":"2025-05-07T11:12:30Z","month":"06","_id":"6262","date_published":"2019-06-01T00:00:00Z","ec_funded":1,"publisher":"Wiley","file_date_updated":"2020-07-14T12:47:25Z","abstract":[{"text":"Gravitropism is an adaptive response that orients plant growth parallel to the gravity vector. Asymmetric\r\ndistribution of the phytohormone auxin is a necessary prerequisite to the tropic bending both in roots and\r\nshoots. During hypocotyl gravitropic response, the PIN3 auxin transporter polarizes within gravity-sensing\r\ncells to redirect intercellular auxin fluxes. First gravity-induced PIN3 polarization to the bottom cell mem-\r\nbranes leads to the auxin accumulation at the lower side of the organ, initiating bending and, later, auxin\r\nfeedback-mediated repolarization restores symmetric auxin distribution to terminate bending. Here, we per-\r\nformed a forward genetic screen to identify regulators of both PIN3 polarization events during gravitropic\r\nresponse. We searched for mutants with defective PIN3 polarizations based on easy-to-score morphological\r\noutputs of decreased or increased gravity-induced hypocotyl bending. We identified the number of\r\nhypocotyl reduced bending (hrb) and hypocotyl hyperbending (hhb) mutants, revealing that reduced bending corre-\r\nlated typically with defective gravity-induced PIN3 relocation whereas all analyzed hhb mutants showed\r\ndefects in the second, auxin-mediated PIN3 relocation. Next-generation sequencing-aided mutation map-\r\nping identified several candidate genes, including SCARECROW and ACTIN2, revealing roles of endodermis\r\nspecification and actin cytoskeleton in the respective gravity- and auxin-induced PIN polarization events.\r\nThe hypocotyl gravitropism screen thus promises to provide novel insights into mechanisms underlying cell\r\npolarity and plant adaptive development.","lang":"eng"}],"citation":{"apa":"Rakusová, H., Han, H., Valošek, P., &#38; Friml, J. (2019). Genetic screen for factors mediating PIN polarization in gravistimulated Arabidopsis thaliana hypocotyls. <i>The Plant Journal</i>. Wiley. <a href=\"https://doi.org/10.1111/tpj.14301\">https://doi.org/10.1111/tpj.14301</a>","mla":"Rakusová, Hana, et al. “Genetic Screen for Factors Mediating PIN Polarization in Gravistimulated Arabidopsis Thaliana Hypocotyls.” <i>The Plant Journal</i>, vol. 98, no. 6, Wiley, 2019, pp. 1048–59, doi:<a href=\"https://doi.org/10.1111/tpj.14301\">10.1111/tpj.14301</a>.","chicago":"Rakusová, Hana, Huibin Han, Petr Valošek, and Jiří Friml. “Genetic Screen for Factors Mediating PIN Polarization in Gravistimulated Arabidopsis Thaliana Hypocotyls.” <i>The Plant Journal</i>. Wiley, 2019. <a href=\"https://doi.org/10.1111/tpj.14301\">https://doi.org/10.1111/tpj.14301</a>.","ama":"Rakusová H, Han H, Valošek P, Friml J. Genetic screen for factors mediating PIN polarization in gravistimulated Arabidopsis thaliana hypocotyls. <i>The Plant Journal</i>. 2019;98(6):1048-1059. doi:<a href=\"https://doi.org/10.1111/tpj.14301\">10.1111/tpj.14301</a>","short":"H. Rakusová, H. Han, P. Valošek, J. Friml, The Plant Journal 98 (2019) 1048–1059.","ista":"Rakusová H, Han H, Valošek P, Friml J. 2019. Genetic screen for factors mediating PIN polarization in gravistimulated Arabidopsis thaliana hypocotyls. The Plant Journal. 98(6), 1048–1059.","ieee":"H. Rakusová, H. Han, P. Valošek, and J. Friml, “Genetic screen for factors mediating PIN polarization in gravistimulated Arabidopsis thaliana hypocotyls,” <i>The Plant Journal</i>, vol. 98, no. 6. Wiley, pp. 1048–1059, 2019."},"department":[{"_id":"JiFr"}],"day":"01","type":"journal_article","issue":"6","isi":1,"article_processing_charge":"Yes (via OA deal)","oa_version":"Published Version","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"volume":98,"article_type":"original","publication_identifier":{"issn":["0960-7412"],"eissn":["1365-313x"]},"status":"public","project":[{"_id":"25716A02-B435-11E9-9278-68D0E5697425","name":"Polarity and subcellular dynamics in plants","call_identifier":"FP7","grant_number":"282300"}],"external_id":{"pmid":["30821050"],"isi":["000473644100008"]},"publication":"The Plant Journal","ddc":["580"],"oa":1,"page":"1048-1059","quality_controlled":"1","title":"Genetic screen for factors mediating PIN polarization in gravistimulated Arabidopsis thaliana hypocotyls","file":[{"date_updated":"2020-07-14T12:47:25Z","creator":"dernst","content_type":"application/pdf","file_size":1383100,"file_id":"6304","date_created":"2019-04-15T09:38:43Z","relation":"main_file","access_level":"open_access","checksum":"ad3b5e270b67ba2a45f894ce3be27920","file_name":"2019_PlantJournal_Rakusov.pdf"}],"intvolume":"        98","doi":"10.1111/tpj.14301","language":[{"iso":"eng"}]}]