[{"volume":10,"issue":"22","article_type":"original","publisher":"American Chemical Society","intvolume":"        10","date_created":"2022-08-24T10:40:46Z","month":"11","status":"public","main_file_link":[{"url":"https://doi.org/10.26434/chemrxiv.12444908","open_access":"1"}],"citation":{"ama":"Reischauer S, Strauss V, Pieber B. Modular, self-assembling metallaphotocatalyst for cross-couplings using the full visible-light spectrum. <i>ACS Catalysis</i>. 2020;10(22):13269–13274. doi:<a href=\"https://doi.org/10.1021/acscatal.0c03950\">10.1021/acscatal.0c03950</a>","ieee":"S. Reischauer, V. Strauss, and B. Pieber, “Modular, self-assembling metallaphotocatalyst for cross-couplings using the full visible-light spectrum,” <i>ACS Catalysis</i>, vol. 10, no. 22. American Chemical Society, pp. 13269–13274, 2020.","chicago":"Reischauer, Susanne, Volker Strauss, and Bartholomäus Pieber. “Modular, Self-Assembling Metallaphotocatalyst for Cross-Couplings Using the Full Visible-Light Spectrum.” <i>ACS Catalysis</i>. American Chemical Society, 2020. <a href=\"https://doi.org/10.1021/acscatal.0c03950\">https://doi.org/10.1021/acscatal.0c03950</a>.","short":"S. Reischauer, V. Strauss, B. Pieber, ACS Catalysis 10 (2020) 13269–13274.","ista":"Reischauer S, Strauss V, Pieber B. 2020. Modular, self-assembling metallaphotocatalyst for cross-couplings using the full visible-light spectrum. ACS Catalysis. 10(22), 13269–13274.","mla":"Reischauer, Susanne, et al. “Modular, Self-Assembling Metallaphotocatalyst for Cross-Couplings Using the Full Visible-Light Spectrum.” <i>ACS Catalysis</i>, vol. 10, no. 22, American Chemical Society, 2020, pp. 13269–13274, doi:<a href=\"https://doi.org/10.1021/acscatal.0c03950\">10.1021/acscatal.0c03950</a>.","apa":"Reischauer, S., Strauss, V., &#38; Pieber, B. (2020). Modular, self-assembling metallaphotocatalyst for cross-couplings using the full visible-light spectrum. <i>ACS Catalysis</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acscatal.0c03950\">https://doi.org/10.1021/acscatal.0c03950</a>"},"quality_controlled":"1","author":[{"first_name":"Susanne","last_name":"Reischauer","full_name":"Reischauer, Susanne"},{"first_name":"Volker","last_name":"Strauss","full_name":"Strauss, Volker"},{"first_name":"Bartholomäus","last_name":"Pieber","id":"93e5e5b2-0da6-11ed-8a41-af589a024726","full_name":"Pieber, Bartholomäus","orcid":"0000-0001-8689-388X"}],"extern":"1","year":"2020","publication":"ACS Catalysis","title":"Modular, self-assembling metallaphotocatalyst for cross-couplings using the full visible-light spectrum","oa":1,"_id":"11954","publication_status":"published","abstract":[{"lang":"eng","text":"The combination of nickel and photocatalysis has unlocked a variety of cross-couplings. These protocols rely on a few photocatalysts that can only convert a small portion of visible light (<500 nm) into chemical energy. The high-energy photons that excite the photocatalyst can result in unwanted side reactions. Dyes that absorb a much broader spectrum of light are not applicable because of their short-lived singlet excited states. Here, we describe a self-assembling catalyst system that overcomes this limitation. Immobilization of a nickel catalyst on dye-sensitized titanium dioxide results in a material that catalyzes carbon–heteroatom and carbon–carbon bond formations. The modular approach of dye-sensitized metallaphotocatalysts accesses the entire visible light spectrum and allows tackling selectivity issues resulting from low wavelengths strategically. The concept overcomes current limitations of metallaphotocatalysis by unlocking the potential of dyes that were previously unsuitable."}],"date_published":"2020-11-02T00:00:00Z","page":"13269–13274","publication_identifier":{"eissn":["2155-5435"]},"scopus_import":"1","article_processing_charge":"No","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"journal_article","date_updated":"2023-02-21T10:09:09Z","oa_version":"Preprint","day":"02","doi":"10.1021/acscatal.0c03950","language":[{"iso":"eng"}]},{"publication_identifier":{"eissn":["2367-0932"]},"scopus_import":"1","date_published":"2020-07-01T00:00:00Z","page":"454-454","doi":"10.1002/cptc.202000137","language":[{"iso":"eng"}],"article_processing_charge":"No","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2023-02-21T10:09:40Z","type":"journal_article","oa_version":"None","day":"01","intvolume":"         4","date_created":"2022-08-25T08:33:38Z","month":"07","status":"public","issue":"7","volume":4,"article_type":"original","publisher":"Wiley","title":"Heterogeneous photocatalysis in organic synthesis","publication":"ChemPhotoChem","_id":"11966","publication_status":"published","abstract":[{"text":"The front cover artwork is provided by the group of Dr. Bartholomäus Pieber at the Max Planck Institute of Colloids and Interfaces (Germany). The image symbolizes the activation of a heterogeneous photocatalyst by visible light and its application for organic synthesis. Read the full text of the Review at 10.1002/cptc.202000014.","lang":"eng"}],"citation":{"apa":"Gisbertz, S., &#38; Pieber, B. (2020). Heterogeneous photocatalysis in organic synthesis. <i>ChemPhotoChem</i>. Wiley. <a href=\"https://doi.org/10.1002/cptc.202000137\">https://doi.org/10.1002/cptc.202000137</a>","mla":"Gisbertz, Sebastian, and Bartholomäus Pieber. “Heterogeneous Photocatalysis in Organic Synthesis.” <i>ChemPhotoChem</i>, vol. 4, no. 7, Wiley, 2020, pp. 454–454, doi:<a href=\"https://doi.org/10.1002/cptc.202000137\">10.1002/cptc.202000137</a>.","chicago":"Gisbertz, Sebastian, and Bartholomäus Pieber. “Heterogeneous Photocatalysis in Organic Synthesis.” <i>ChemPhotoChem</i>. Wiley, 2020. <a href=\"https://doi.org/10.1002/cptc.202000137\">https://doi.org/10.1002/cptc.202000137</a>.","short":"S. Gisbertz, B. Pieber, ChemPhotoChem 4 (2020) 454–454.","ista":"Gisbertz S, Pieber B. 2020. Heterogeneous photocatalysis in organic synthesis. ChemPhotoChem. 4(7), 454–454.","ieee":"S. Gisbertz and B. Pieber, “Heterogeneous photocatalysis in organic synthesis,” <i>ChemPhotoChem</i>, vol. 4, no. 7. Wiley, pp. 454–454, 2020.","ama":"Gisbertz S, Pieber B. Heterogeneous photocatalysis in organic synthesis. <i>ChemPhotoChem</i>. 2020;4(7):454-454. doi:<a href=\"https://doi.org/10.1002/cptc.202000137\">10.1002/cptc.202000137</a>"},"quality_controlled":"1","extern":"1","author":[{"full_name":"Gisbertz, Sebastian","first_name":"Sebastian","last_name":"Gisbertz"},{"id":"93e5e5b2-0da6-11ed-8a41-af589a024726","full_name":"Pieber, Bartholomäus","orcid":"0000-0001-8689-388X","first_name":"Bartholomäus","last_name":"Pieber"}],"year":"2020"},{"language":[{"iso":"eng"}],"doi":"10.1002/ejoc.201901173","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_processing_charge":"No","type":"journal_article","date_updated":"2023-02-21T10:09:47Z","oa_version":"Published Version","day":"15","publication_identifier":{"eissn":["1099-0690"],"issn":["1434-193X"]},"scopus_import":"1","date_published":"2020-03-15T00:00:00Z","page":"1379-1392","title":"Photochemical strategies for carbon–heteroatom bond formation","publication":"European Journal of Organic Chemistry","oa":1,"_id":"11969","publication_status":"published","abstract":[{"text":"Photochemistry enables new synthetic means to form carbon–heteroatom bonds. Photocatalysts can catalyze carbon–heteroatom cross-couplings by electron or energy transfer either alone or in combination with a second catalyst. Photocatalyst-free methods are possible using photolabile substrates or by generating photoactive electron donor-acceptor complexes. This review summarizes and discusses the strategies used in light-mediated carbon–heteroatom bond formations based on the proposed mechanisms.","lang":"eng"}],"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1002/ejoc.201901173"}],"citation":{"mla":"Cavedon, Cristian, et al. “Photochemical Strategies for Carbon–Heteroatom Bond Formation.” <i>European Journal of Organic Chemistry</i>, vol. 2020, no. 10, Wiley, 2020, pp. 1379–92, doi:<a href=\"https://doi.org/10.1002/ejoc.201901173\">10.1002/ejoc.201901173</a>.","apa":"Cavedon, C., Seeberger, P. H., &#38; Pieber, B. (2020). Photochemical strategies for carbon–heteroatom bond formation. <i>European Journal of Organic Chemistry</i>. Wiley. <a href=\"https://doi.org/10.1002/ejoc.201901173\">https://doi.org/10.1002/ejoc.201901173</a>","ama":"Cavedon C, Seeberger PH, Pieber B. Photochemical strategies for carbon–heteroatom bond formation. <i>European Journal of Organic Chemistry</i>. 2020;2020(10):1379-1392. doi:<a href=\"https://doi.org/10.1002/ejoc.201901173\">10.1002/ejoc.201901173</a>","ieee":"C. Cavedon, P. H. Seeberger, and B. Pieber, “Photochemical strategies for carbon–heteroatom bond formation,” <i>European Journal of Organic Chemistry</i>, vol. 2020, no. 10. Wiley, pp. 1379–1392, 2020.","chicago":"Cavedon, Cristian, Peter H. Seeberger, and Bartholomäus Pieber. “Photochemical Strategies for Carbon–Heteroatom Bond Formation.” <i>European Journal of Organic Chemistry</i>. Wiley, 2020. <a href=\"https://doi.org/10.1002/ejoc.201901173\">https://doi.org/10.1002/ejoc.201901173</a>.","short":"C. Cavedon, P.H. Seeberger, B. Pieber, European Journal of Organic Chemistry 2020 (2020) 1379–1392.","ista":"Cavedon C, Seeberger PH, Pieber B. 2020. Photochemical strategies for carbon–heteroatom bond formation. European Journal of Organic Chemistry. 2020(10), 1379–1392."},"quality_controlled":"1","extern":"1","author":[{"full_name":"Cavedon, Cristian","last_name":"Cavedon","first_name":"Cristian"},{"full_name":"Seeberger, Peter H.","first_name":"Peter H.","last_name":"Seeberger"},{"last_name":"Pieber","first_name":"Bartholomäus","id":"93e5e5b2-0da6-11ed-8a41-af589a024726","full_name":"Pieber, Bartholomäus","orcid":"0000-0001-8689-388X"}],"year":"2020","intvolume":"      2020","date_created":"2022-08-25T08:49:25Z","month":"03","status":"public","volume":2020,"issue":"10","publisher":"Wiley","article_type":"review"},{"doi":"10.1021/jacs.0c02848","language":[{"iso":"eng"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_processing_charge":"No","day":"24","oa_version":"Published Version","date_updated":"2023-02-21T10:10:06Z","type":"journal_article","scopus_import":"1","publication_identifier":{"eissn":["1520-5126"],"issn":["0002-7863"]},"page":"11042-11049","external_id":{"pmid":["32469219"]},"date_published":"2020-06-24T00:00:00Z","_id":"11978","oa":1,"pmid":1,"title":"Evidence for photocatalyst involvement in oxidative additions of nickel-catalyzed carboxylate O-arylations","publication":"Journal of the American Chemical Society","abstract":[{"text":"Dual photocatalysis and nickel catalysis can effect cross-coupling under mild conditions, but little is known about the in situ kinetics of this class of reactions. We report a comprehensive kinetic examination of a model carboxylate O-arylation, comparing a state-of-the-art homogeneous photocatalyst (Ir(ppy)3) with a competitive heterogeneous photocatalyst (graphitic carbon nitride). Experimental conditions were adjusted such that the nickel catalytic cycle is saturated with excited photocatalyst. This approach was designed to remove the role of the photocatalyst, by which only the intrinsic behaviors of the nickel catalytic cycles are observed. The two reactions did not display identical kinetics. Ir(ppy)3 deactivates the nickel catalytic cycle and creates more dehalogenated side product. Kinetic data for the reaction using Ir(ppy)3 supports a turnover-limiting reductive elimination. Graphitic carbon nitride gave higher selectivity, even at high photocatalyst-to-nickel ratios. The heterogeneous reaction also showed a rate dependence on aryl halide, indicating that oxidative addition plays a role in rate determination. The results argue against the current mechanistic hypothesis, which states that the photocatalyst is only involved to trigger reductive elimination.","lang":"eng"}],"publication_status":"published","extern":"1","quality_controlled":"1","author":[{"first_name":"Jamal A.","last_name":"Malik","full_name":"Malik, Jamal A."},{"full_name":"Madani, Amiera","first_name":"Amiera","last_name":"Madani"},{"full_name":"Pieber, Bartholomäus","orcid":"0000-0001-8689-388X","id":"93e5e5b2-0da6-11ed-8a41-af589a024726","last_name":"Pieber","first_name":"Bartholomäus"},{"full_name":"Seeberger, Peter H.","last_name":"Seeberger","first_name":"Peter H."}],"main_file_link":[{"url":"https://doi.org/10.1021/jacs.0c02848","open_access":"1"}],"citation":{"ista":"Malik JA, Madani A, Pieber B, Seeberger PH. 2020. Evidence for photocatalyst involvement in oxidative additions of nickel-catalyzed carboxylate O-arylations. Journal of the American Chemical Society. 142(25), 11042–11049.","short":"J.A. Malik, A. Madani, B. Pieber, P.H. Seeberger, Journal of the American Chemical Society 142 (2020) 11042–11049.","chicago":"Malik, Jamal A., Amiera Madani, Bartholomäus Pieber, and Peter H. Seeberger. “Evidence for Photocatalyst Involvement in Oxidative Additions of Nickel-Catalyzed Carboxylate O-Arylations.” <i>Journal of the American Chemical Society</i>. American Chemical Society, 2020. <a href=\"https://doi.org/10.1021/jacs.0c02848\">https://doi.org/10.1021/jacs.0c02848</a>.","ieee":"J. A. Malik, A. Madani, B. Pieber, and P. H. Seeberger, “Evidence for photocatalyst involvement in oxidative additions of nickel-catalyzed carboxylate O-arylations,” <i>Journal of the American Chemical Society</i>, vol. 142, no. 25. American Chemical Society, pp. 11042–11049, 2020.","ama":"Malik JA, Madani A, Pieber B, Seeberger PH. Evidence for photocatalyst involvement in oxidative additions of nickel-catalyzed carboxylate O-arylations. <i>Journal of the American Chemical Society</i>. 2020;142(25):11042-11049. doi:<a href=\"https://doi.org/10.1021/jacs.0c02848\">10.1021/jacs.0c02848</a>","apa":"Malik, J. A., Madani, A., Pieber, B., &#38; Seeberger, P. H. (2020). Evidence for photocatalyst involvement in oxidative additions of nickel-catalyzed carboxylate O-arylations. <i>Journal of the American Chemical Society</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/jacs.0c02848\">https://doi.org/10.1021/jacs.0c02848</a>","mla":"Malik, Jamal A., et al. “Evidence for Photocatalyst Involvement in Oxidative Additions of Nickel-Catalyzed Carboxylate O-Arylations.” <i>Journal of the American Chemical Society</i>, vol. 142, no. 25, American Chemical Society, 2020, pp. 11042–49, doi:<a href=\"https://doi.org/10.1021/jacs.0c02848\">10.1021/jacs.0c02848</a>."},"year":"2020","intvolume":"       142","status":"public","month":"06","date_created":"2022-08-25T10:57:38Z","volume":142,"issue":"25","article_type":"original","publisher":"American Chemical Society"},{"language":[{"iso":"eng"}],"doi":"10.1038/s41929-020-0473-6","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_processing_charge":"No","day":"01","oa_version":"Preprint","type":"journal_article","date_updated":"2023-02-21T10:10:09Z","scopus_import":"1","publication_identifier":{"eissn":["2520-1158"]},"page":"611-620","date_published":"2020-08-01T00:00:00Z","_id":"11979","oa":1,"publication":"Nature Catalysis","title":"Overcoming limitations in dual photoredox/nickel-catalysed C–N cross-couplings due to catalyst deactivation","abstract":[{"lang":"eng","text":"Dual photoredox/nickel-catalysed C–N cross-couplings suffer from low yields for electron-rich aryl halides. The formation of catalytically inactive nickel-black is responsible for this limitation and causes severe reproducibility issues. Here, we demonstrate that catalyst deactivation can be avoided by using a carbon nitride photocatalyst. The broad absorption of the heterogeneous photocatalyst enables wavelength-dependent control of the rate of reductive elimination to prevent nickel-black formation during the coupling of cyclic, secondary amines and aryl halides. A second approach, which is applicable to a broader set of electron-rich aryl halides, is to run the reactions at high concentrations to increase the rate of oxidative addition. Less nucleophilic, primary amines can be coupled with electron-rich aryl halides by stabilizing low-valent nickel intermediates with a suitable additive. The developed protocols enable reproducible, selective C–N cross-couplings of electron-rich aryl bromides and can also be applied for electron-poor aryl chlorides."}],"publication_status":"published","quality_controlled":"1","author":[{"first_name":"Sebastian","last_name":"Gisbertz","full_name":"Gisbertz, Sebastian"},{"full_name":"Reischauer, Susanne","first_name":"Susanne","last_name":"Reischauer"},{"first_name":"Bartholomäus","last_name":"Pieber","orcid":"0000-0001-8689-388X","full_name":"Pieber, Bartholomäus","id":"93e5e5b2-0da6-11ed-8a41-af589a024726"}],"extern":"1","citation":{"mla":"Gisbertz, Sebastian, et al. “Overcoming Limitations in Dual Photoredox/Nickel-Catalysed C–N Cross-Couplings Due to Catalyst Deactivation.” <i>Nature Catalysis</i>, vol. 3, no. 8, Springer Nature, 2020, pp. 611–20, doi:<a href=\"https://doi.org/10.1038/s41929-020-0473-6\">10.1038/s41929-020-0473-6</a>.","apa":"Gisbertz, S., Reischauer, S., &#38; Pieber, B. (2020). Overcoming limitations in dual photoredox/nickel-catalysed C–N cross-couplings due to catalyst deactivation. <i>Nature Catalysis</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41929-020-0473-6\">https://doi.org/10.1038/s41929-020-0473-6</a>","chicago":"Gisbertz, Sebastian, Susanne Reischauer, and Bartholomäus Pieber. “Overcoming Limitations in Dual Photoredox/Nickel-Catalysed C–N Cross-Couplings Due to Catalyst Deactivation.” <i>Nature Catalysis</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41929-020-0473-6\">https://doi.org/10.1038/s41929-020-0473-6</a>.","short":"S. Gisbertz, S. Reischauer, B. Pieber, Nature Catalysis 3 (2020) 611–620.","ista":"Gisbertz S, Reischauer S, Pieber B. 2020. Overcoming limitations in dual photoredox/nickel-catalysed C–N cross-couplings due to catalyst deactivation. Nature Catalysis. 3(8), 611–620.","ieee":"S. Gisbertz, S. Reischauer, and B. Pieber, “Overcoming limitations in dual photoredox/nickel-catalysed C–N cross-couplings due to catalyst deactivation,” <i>Nature Catalysis</i>, vol. 3, no. 8. Springer Nature, pp. 611–620, 2020.","ama":"Gisbertz S, Reischauer S, Pieber B. Overcoming limitations in dual photoredox/nickel-catalysed C–N cross-couplings due to catalyst deactivation. <i>Nature Catalysis</i>. 2020;3(8):611-620. doi:<a href=\"https://doi.org/10.1038/s41929-020-0473-6\">10.1038/s41929-020-0473-6</a>"},"main_file_link":[{"open_access":"1","url":"https://doi.org/10.26434/chemrxiv.10298735"}],"year":"2020","intvolume":"         3","status":"public","month":"08","date_created":"2022-08-25T11:06:16Z","volume":3,"issue":"8","publisher":"Springer Nature","article_type":"original"},{"publication_status":"published","abstract":[{"text":"Small organic radicals are ubiquitous intermediates in photocatalysis and are used in organic synthesis to install functional groups and to tune electronic properties and pharmacokinetic parameters of the final molecule. Development of new methods to generate small organic radicals with added functionality can further extend the utility of photocatalysis for synthetic needs. Herein, we present a method to generate dichloromethyl radicals from chloroform using a heterogeneous potassium poly(heptazine imide) (K-PHI) photocatalyst under visible light irradiation for C1-extension of the enone backbone. The method is applied on 15 enones, with γ,γ-dichloroketones yields of 18–89%. Due to negative zeta-potential (−40 mV) and small particle size (100 nm) K-PHI suspension is used in quasi-homogeneous flow-photoreactor increasing the productivity by 19 times compared to the batch approach. The resulting γ,γ-dichloroketones, are used as bifunctional building blocks to access value-added organic compounds such as substituted furans and pyrroles.","lang":"eng"}],"oa":1,"_id":"11980","publication":"Nature Communications","title":"Dichloromethylation of enones by carbon nitride photocatalysis","year":"2020","quality_controlled":"1","author":[{"last_name":"Mazzanti","first_name":"Stefano","full_name":"Mazzanti, Stefano"},{"full_name":"Kurpil, Bogdan","first_name":"Bogdan","last_name":"Kurpil"},{"id":"93e5e5b2-0da6-11ed-8a41-af589a024726","full_name":"Pieber, Bartholomäus","orcid":"0000-0001-8689-388X","last_name":"Pieber","first_name":"Bartholomäus"},{"first_name":"Markus","last_name":"Antonietti","full_name":"Antonietti, Markus"},{"first_name":"Aleksandr","last_name":"Savateev","full_name":"Savateev, Aleksandr"}],"extern":"1","citation":{"chicago":"Mazzanti, Stefano, Bogdan Kurpil, Bartholomäus Pieber, Markus Antonietti, and Aleksandr Savateev. “Dichloromethylation of Enones by Carbon Nitride Photocatalysis.” <i>Nature Communications</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41467-020-15131-0\">https://doi.org/10.1038/s41467-020-15131-0</a>.","short":"S. Mazzanti, B. Kurpil, B. Pieber, M. Antonietti, A. Savateev, Nature Communications 11 (2020).","ista":"Mazzanti S, Kurpil B, Pieber B, Antonietti M, Savateev A. 2020. Dichloromethylation of enones by carbon nitride photocatalysis. Nature Communications. 11, 1387.","ieee":"S. Mazzanti, B. Kurpil, B. Pieber, M. Antonietti, and A. Savateev, “Dichloromethylation of enones by carbon nitride photocatalysis,” <i>Nature Communications</i>, vol. 11. Springer Nature, 2020.","ama":"Mazzanti S, Kurpil B, Pieber B, Antonietti M, Savateev A. Dichloromethylation of enones by carbon nitride photocatalysis. <i>Nature Communications</i>. 2020;11. doi:<a href=\"https://doi.org/10.1038/s41467-020-15131-0\">10.1038/s41467-020-15131-0</a>","mla":"Mazzanti, Stefano, et al. “Dichloromethylation of Enones by Carbon Nitride Photocatalysis.” <i>Nature Communications</i>, vol. 11, 1387, Springer Nature, 2020, doi:<a href=\"https://doi.org/10.1038/s41467-020-15131-0\">10.1038/s41467-020-15131-0</a>.","apa":"Mazzanti, S., Kurpil, B., Pieber, B., Antonietti, M., &#38; Savateev, A. (2020). Dichloromethylation of enones by carbon nitride photocatalysis. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-020-15131-0\">https://doi.org/10.1038/s41467-020-15131-0</a>"},"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1038/s41467-020-15131-0"}],"article_number":"1387","status":"public","date_created":"2022-08-25T11:10:15Z","month":"03","intvolume":"        11","article_type":"original","publisher":"Springer Nature","volume":11,"language":[{"iso":"eng"}],"doi":"10.1038/s41467-020-15131-0","day":"13","type":"journal_article","date_updated":"2023-02-21T10:10:14Z","oa_version":"Published Version","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_processing_charge":"No","publication_identifier":{"eissn":["2041-1723"]},"scopus_import":"1","date_published":"2020-03-13T00:00:00Z"},{"volume":5,"issue":"3","article_type":"original","publisher":"Royal Society of Chemistry","intvolume":"         5","date_created":"2022-08-25T11:45:02Z","month":"03","status":"public","citation":{"ama":"Rosso C, Gisbertz S, Williams JD, et al. An oscillatory plug flow photoreactor facilitates semi-heterogeneous dual nickel/carbon nitride photocatalytic C–N couplings. <i>Reaction Chemistry and Engineering</i>. 2020;5(3):597-604. doi:<a href=\"https://doi.org/10.1039/d0re00036a\">10.1039/d0re00036a</a>","ieee":"C. Rosso <i>et al.</i>, “An oscillatory plug flow photoreactor facilitates semi-heterogeneous dual nickel/carbon nitride photocatalytic C–N couplings,” <i>Reaction Chemistry and Engineering</i>, vol. 5, no. 3. Royal Society of Chemistry, pp. 597–604, 2020.","short":"C. Rosso, S. Gisbertz, J.D. Williams, H.P.L. Gemoets, W. Debrouwer, B. Pieber, C.O. Kappe, Reaction Chemistry and Engineering 5 (2020) 597–604.","chicago":"Rosso, Cristian, Sebastian Gisbertz, Jason D. Williams, Hannes P. L. Gemoets, Wouter Debrouwer, Bartholomäus Pieber, and C. Oliver Kappe. “An Oscillatory Plug Flow Photoreactor Facilitates Semi-Heterogeneous Dual Nickel/Carbon Nitride Photocatalytic C–N Couplings.” <i>Reaction Chemistry and Engineering</i>. Royal Society of Chemistry, 2020. <a href=\"https://doi.org/10.1039/d0re00036a\">https://doi.org/10.1039/d0re00036a</a>.","ista":"Rosso C, Gisbertz S, Williams JD, Gemoets HPL, Debrouwer W, Pieber B, Kappe CO. 2020. An oscillatory plug flow photoreactor facilitates semi-heterogeneous dual nickel/carbon nitride photocatalytic C–N couplings. Reaction Chemistry and Engineering. 5(3), 597–604.","apa":"Rosso, C., Gisbertz, S., Williams, J. D., Gemoets, H. P. L., Debrouwer, W., Pieber, B., &#38; Kappe, C. O. (2020). An oscillatory plug flow photoreactor facilitates semi-heterogeneous dual nickel/carbon nitride photocatalytic C–N couplings. <i>Reaction Chemistry and Engineering</i>. Royal Society of Chemistry. <a href=\"https://doi.org/10.1039/d0re00036a\">https://doi.org/10.1039/d0re00036a</a>","mla":"Rosso, Cristian, et al. “An Oscillatory Plug Flow Photoreactor Facilitates Semi-Heterogeneous Dual Nickel/Carbon Nitride Photocatalytic C–N Couplings.” <i>Reaction Chemistry and Engineering</i>, vol. 5, no. 3, Royal Society of Chemistry, 2020, pp. 597–604, doi:<a href=\"https://doi.org/10.1039/d0re00036a\">10.1039/d0re00036a</a>."},"main_file_link":[{"url":"https://doi.org/10.1039/D0RE00036A","open_access":"1"}],"quality_controlled":"1","author":[{"full_name":"Rosso, Cristian","first_name":"Cristian","last_name":"Rosso"},{"last_name":"Gisbertz","first_name":"Sebastian","full_name":"Gisbertz, Sebastian"},{"first_name":"Jason D.","last_name":"Williams","full_name":"Williams, Jason D."},{"first_name":"Hannes P. L.","last_name":"Gemoets","full_name":"Gemoets, Hannes P. L."},{"full_name":"Debrouwer, Wouter","first_name":"Wouter","last_name":"Debrouwer"},{"last_name":"Pieber","first_name":"Bartholomäus","full_name":"Pieber, Bartholomäus","orcid":"0000-0001-8689-388X","id":"93e5e5b2-0da6-11ed-8a41-af589a024726"},{"first_name":"C. Oliver","last_name":"Kappe","full_name":"Kappe, C. Oliver"}],"extern":"1","year":"2020","publication":"Reaction Chemistry and Engineering","title":"An oscillatory plug flow photoreactor facilitates semi-heterogeneous dual nickel/carbon nitride photocatalytic C–N couplings","oa":1,"_id":"11986","publication_status":"published","abstract":[{"lang":"eng","text":"Carbon nitride materials have emerged as an efficient and sustainable class of heterogeneous photocatalysts, particularly when paired with nickel in dual catalytic cross-coupling reactions. Performing these transformations on larger scales using a continuous process is difficult due to the problems associated with handling solids in flow. By combining an oscillatory pump with a microstructured plug flow photoreactor, a stable suspension of the photocatalyst can be maintained, circumventing clogging of the reactor channels. Through careful tuning of the oscillator properties, the residence time distribution (RTD) was optimized, whilst maintaining a stable catalyst suspension. Short residence times (20 min) were achieved using optimized conditions and the recyclability of the photocatalyst was demonstrated over 10 cycles with no loss of activity. During a stable 4.5 hour scale-out demonstration, the model substrate could be isolated on 12 g scale (90% yield, 2.67 g h−1). Moreover, the method was applied for the gram scale synthesis of an intermediate of the active pharmaceutical ingredient tetracaine."}],"date_published":"2020-03-01T00:00:00Z","page":"597-604","publication_identifier":{"eissn":["2058-9883"]},"scopus_import":"1","article_processing_charge":"No","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"journal_article","date_updated":"2023-02-21T10:10:28Z","oa_version":"Published Version","day":"01","language":[{"iso":"eng"}],"doi":"10.1039/d0re00036a"},{"publication_identifier":{"issn":["0960-9822"]},"scopus_import":"1","page":"2676-2686.e3","date_published":"2019-08-19T00:00:00Z","keyword":["General Agricultural and Biological Sciences","General Biochemistry","Genetics and Molecular Biology"],"external_id":{"pmid":["31378616"]},"doi":"10.1016/j.cub.2019.06.084","language":[{"iso":"eng"}],"department":[{"_id":"XiFe"}],"acknowledgement":"We thank Gregory Copenhaver (University of North Carolina), Avraham Levy (The Weizmann Institute), and Scott Poethig (University of Pennsylvania) for FTLs; Piotr Ziolkowski for Col-420/Bur seed; Sureshkumar Balasubramanian\r\n(Monash University) for providing British and Irish Arabidopsis accessions; Mathilde Grelon (INRA, Versailles) for providing the MLH1 antibody; and the Gurdon Institute for access to microscopes. This work was supported by a BBSRC DTP studentship (E.J.L.), European Research Area Network for Coordinating Action in Plant Sciences/BBSRC ‘‘DeCOP’’ (BB/M004937/1; C.L.), a BBSRC David Phillips Fellowship (BB/L025043/1; H.G. and X.F.), the European Research Council (CoG ‘‘SynthHotspot,’’ A.J.T., C.L., and I.R.H.; StG ‘‘SexMeth,’’ X.F.), and a Sainsbury Charitable Foundation Studentship (A.R.B.).","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_processing_charge":"No","day":"19","type":"journal_article","date_updated":"2023-05-08T10:54:54Z","oa_version":"None","intvolume":"        29","status":"public","date_created":"2023-01-16T09:16:33Z","month":"08","volume":29,"issue":"16","publisher":"Elsevier BV","article_type":"original","_id":"12190","title":"Natural variation in TBP-ASSOCIATED FACTOR 4b controls meiotic crossover and germline transcription in Arabidopsis","publication":"Current Biology","pmid":1,"publication_status":"published","abstract":[{"lang":"eng","text":"Meiotic crossover frequency varies within genomes, which influences genetic diversity and adaptation. In turn, genetic variation within populations can act to modify crossover frequency in cis and trans. To identify genetic variation that controls meiotic crossover frequency, we screened Arabidopsis accessions using fluorescent recombination reporters. We mapped a genetic modifier of crossover frequency in Col × Bur populations of Arabidopsis to a premature stop codon within TBP-ASSOCIATED FACTOR 4b (TAF4b), which encodes a subunit of the RNA polymerase II general transcription factor TFIID. The Arabidopsis taf4b mutation is a rare variant found in the British Isles, originating in South-West Ireland. Using genetics, genomics, and immunocytology, we demonstrate a genome-wide decrease in taf4b crossovers, with strongest reduction in the sub-telomeric regions. Using RNA sequencing (RNA-seq) from purified meiocytes, we show that TAF4b expression is meiocyte enriched, whereas its paralog TAF4 is broadly expressed. Consistent with the role of TFIID in promoting gene expression, RNA-seq of wild-type and taf4b meiocytes identified widespread transcriptional changes, including in genes that regulate the meiotic cell cycle and recombination. Therefore, TAF4b duplication is associated with acquisition of meiocyte-specific expression and promotion of germline transcription, which act directly or indirectly to elevate crossovers. This identifies a novel mode of meiotic recombination control via a general transcription factor."}],"extern":"1","author":[{"full_name":"Lawrence, Emma J.","first_name":"Emma J.","last_name":"Lawrence"},{"full_name":"Gao, Hongbo","last_name":"Gao","first_name":"Hongbo"},{"last_name":"Tock","first_name":"Andrew J.","full_name":"Tock, Andrew J."},{"first_name":"Christophe","last_name":"Lambing","full_name":"Lambing, Christophe"},{"full_name":"Blackwell, Alexander R.","first_name":"Alexander R.","last_name":"Blackwell"},{"full_name":"Feng, Xiaoqi","orcid":"0000-0002-4008-1234","id":"e0164712-22ee-11ed-b12a-d80fcdf35958","last_name":"Feng","first_name":"Xiaoqi"},{"last_name":"Henderson","first_name":"Ian R.","full_name":"Henderson, Ian R."}],"quality_controlled":"1","citation":{"ieee":"E. J. Lawrence <i>et al.</i>, “Natural variation in TBP-ASSOCIATED FACTOR 4b controls meiotic crossover and germline transcription in Arabidopsis,” <i>Current Biology</i>, vol. 29, no. 16. Elsevier BV, p. 2676–2686.e3, 2019.","ama":"Lawrence EJ, Gao H, Tock AJ, et al. Natural variation in TBP-ASSOCIATED FACTOR 4b controls meiotic crossover and germline transcription in Arabidopsis. <i>Current Biology</i>. 2019;29(16):2676-2686.e3. doi:<a href=\"https://doi.org/10.1016/j.cub.2019.06.084\">10.1016/j.cub.2019.06.084</a>","ista":"Lawrence EJ, Gao H, Tock AJ, Lambing C, Blackwell AR, Feng X, Henderson IR. 2019. Natural variation in TBP-ASSOCIATED FACTOR 4b controls meiotic crossover and germline transcription in Arabidopsis. Current Biology. 29(16), 2676–2686.e3.","short":"E.J. Lawrence, H. Gao, A.J. Tock, C. Lambing, A.R. Blackwell, X. Feng, I.R. Henderson, Current Biology 29 (2019) 2676–2686.e3.","chicago":"Lawrence, Emma J., Hongbo Gao, Andrew J. Tock, Christophe Lambing, Alexander R. Blackwell, Xiaoqi Feng, and Ian R. Henderson. “Natural Variation in TBP-ASSOCIATED FACTOR 4b Controls Meiotic Crossover and Germline Transcription in Arabidopsis.” <i>Current Biology</i>. Elsevier BV, 2019. <a href=\"https://doi.org/10.1016/j.cub.2019.06.084\">https://doi.org/10.1016/j.cub.2019.06.084</a>.","mla":"Lawrence, Emma J., et al. “Natural Variation in TBP-ASSOCIATED FACTOR 4b Controls Meiotic Crossover and Germline Transcription in Arabidopsis.” <i>Current Biology</i>, vol. 29, no. 16, Elsevier BV, 2019, p. 2676–2686.e3, doi:<a href=\"https://doi.org/10.1016/j.cub.2019.06.084\">10.1016/j.cub.2019.06.084</a>.","apa":"Lawrence, E. J., Gao, H., Tock, A. J., Lambing, C., Blackwell, A. R., Feng, X., &#38; Henderson, I. R. (2019). Natural variation in TBP-ASSOCIATED FACTOR 4b controls meiotic crossover and germline transcription in Arabidopsis. <i>Current Biology</i>. Elsevier BV. <a href=\"https://doi.org/10.1016/j.cub.2019.06.084\">https://doi.org/10.1016/j.cub.2019.06.084</a>"},"year":"2019"},{"scopus_import":"1","publication_identifier":{"issn":["2050-084X"]},"external_id":{"unknown":["31135340"]},"keyword":["General Immunology and Microbiology","General Biochemistry","Genetics and Molecular Biology","General Medicine","General Neuroscience"],"file":[{"access_level":"open_access","checksum":"ea6b89c20d59e5eb3646916fe5d568ad","file_name":"2019_elife_He.pdf","file_id":"12525","date_updated":"2023-02-07T09:42:46Z","success":1,"file_size":2493837,"content_type":"application/pdf","creator":"alisjak","date_created":"2023-02-07T09:42:46Z","relation":"main_file"}],"date_published":"2019-05-28T00:00:00Z","department":[{"_id":"XiFe"}],"has_accepted_license":"1","doi":"10.7554/elife.42530","language":[{"iso":"eng"}],"acknowledgement":"We thank David Twell for the pDONR-P4-P1R-pLAT52 and pDONR-P2R-P3-mRFP vectors, the John Innes Centre Bioimaging Facility (Elaine Barclay and Grant Calder) for their assistance with microscopy, and the Norwich BioScience Institute Partnership Computing infrastructure for Science Group for High Performance Computing resources. This work was funded by a Biotechnology and Biological Sciences Research Council (BBSRC) David Phillips Fellowship (BB/L025043/1; SH, JZ and XF), a European Research Council Starting Grant ('SexMeth' 804981; XF) and a Grant to Exceptional Researchers by the Gatsby Charitable Foundation (SH and XF).","article_processing_charge":"No","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","day":"28","oa_version":"Published Version","type":"journal_article","date_updated":"2023-05-08T10:54:12Z","intvolume":"         8","status":"public","article_number":"42530","month":"05","date_created":"2023-01-16T09:17:21Z","volume":8,"article_type":"original","publisher":"eLife Sciences Publications, Ltd","file_date_updated":"2023-02-07T09:42:46Z","_id":"12192","ddc":["580"],"oa":1,"publication":"eLife","title":"Natural depletion of histone H1 in sex cells causes DNA demethylation, heterochromatin decondensation and transposon activation","abstract":[{"text":"Transposable elements (TEs), the movement of which can damage the genome, are epigenetically silenced in eukaryotes. Intriguingly, TEs are activated in the sperm companion cell – vegetative cell (VC) – of the flowering plant Arabidopsis thaliana. However, the extent and mechanism of this activation are unknown. Here we show that about 100 heterochromatic TEs are activated in VCs, mostly by DEMETER-catalyzed DNA demethylation. We further demonstrate that DEMETER access to some of these TEs is permitted by the natural depletion of linker histone H1 in VCs. Ectopically expressed H1 suppresses TEs in VCs by reducing DNA demethylation and via a methylation-independent mechanism. We demonstrate that H1 is required for heterochromatin condensation in plant cells and show that H1 overexpression creates heterochromatic foci in the VC progenitor cell. Taken together, our results demonstrate that the natural depletion of H1 during male gametogenesis facilitates DEMETER-directed DNA demethylation, heterochromatin relaxation, and TE activation.","lang":"eng"}],"publication_status":"published","extern":"1","quality_controlled":"1","author":[{"first_name":"Shengbo","last_name":"He","full_name":"He, Shengbo"},{"full_name":"Vickers, Martin","first_name":"Martin","last_name":"Vickers"},{"first_name":"Jingyi","last_name":"Zhang","full_name":"Zhang, Jingyi"},{"id":"e0164712-22ee-11ed-b12a-d80fcdf35958","full_name":"Feng, Xiaoqi","orcid":"0000-0002-4008-1234","first_name":"Xiaoqi","last_name":"Feng"}],"main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594752/"}],"citation":{"ista":"He S, Vickers M, Zhang J, Feng X. 2019. Natural depletion of histone H1 in sex cells causes DNA demethylation, heterochromatin decondensation and transposon activation. eLife. 8, 42530.","chicago":"He, Shengbo, Martin Vickers, Jingyi Zhang, and Xiaoqi Feng. “Natural Depletion of Histone H1 in Sex Cells Causes DNA Demethylation, Heterochromatin Decondensation and Transposon Activation.” <i>ELife</i>. eLife Sciences Publications, Ltd, 2019. <a href=\"https://doi.org/10.7554/elife.42530\">https://doi.org/10.7554/elife.42530</a>.","short":"S. He, M. Vickers, J. Zhang, X. Feng, ELife 8 (2019).","ieee":"S. He, M. Vickers, J. Zhang, and X. Feng, “Natural depletion of histone H1 in sex cells causes DNA demethylation, heterochromatin decondensation and transposon activation,” <i>eLife</i>, vol. 8. eLife Sciences Publications, Ltd, 2019.","ama":"He S, Vickers M, Zhang J, Feng X. Natural depletion of histone H1 in sex cells causes DNA demethylation, heterochromatin decondensation and transposon activation. <i>eLife</i>. 2019;8. doi:<a href=\"https://doi.org/10.7554/elife.42530\">10.7554/elife.42530</a>","mla":"He, Shengbo, et al. “Natural Depletion of Histone H1 in Sex Cells Causes DNA Demethylation, Heterochromatin Decondensation and Transposon Activation.” <i>ELife</i>, vol. 8, 42530, eLife Sciences Publications, Ltd, 2019, doi:<a href=\"https://doi.org/10.7554/elife.42530\">10.7554/elife.42530</a>.","apa":"He, S., Vickers, M., Zhang, J., &#38; Feng, X. (2019). Natural depletion of histone H1 in sex cells causes DNA demethylation, heterochromatin decondensation and transposon activation. <i>ELife</i>. eLife Sciences Publications, Ltd. <a href=\"https://doi.org/10.7554/elife.42530\">https://doi.org/10.7554/elife.42530</a>"},"year":"2019","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"}},{"scopus_import":"1","publication_identifier":{"eissn":["1944-7973"],"issn":["0043-1397"]},"page":"6754-6772","keyword":["Water Science and Technology"],"date_published":"2019-08-01T00:00:00Z","doi":"10.1029/2019wr024935","language":[{"iso":"eng"}],"day":"01","oa_version":"Published Version","date_updated":"2023-02-28T12:14:18Z","type":"journal_article","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_processing_charge":"No","status":"public","month":"08","date_created":"2023-02-20T08:12:59Z","intvolume":"        55","publisher":"American Geophysical Union","article_type":"original","issue":"8","volume":55,"abstract":[{"text":"The snow cover dynamics of High Mountain Asia are usually assessed at spatial resolutions of 250 m or greater, but this scale is too coarse to clearly represent the rugged topography common to the region. Higher-resolution measurement of snow-covered area often results in biased sampling due to cloud cover and deep shadows. We therefore develop a Normalized Difference Snow Index-based workflow to delineate snow lines from Landsat Thematic Mapper/Enhanced Thematic Mapper+ imagery and apply it to the upper Langtang Valley in Nepal, processing 194 scenes spanning 1999 to 2013. For each scene, we determine the spatial distribution of snow line altitudes (SLAs) with respect to aspect and across six subcatchments. Our results show that the mean SLA exhibits distinct seasonal behavior based on aspect and subcatchment position. We find that SLA dynamics respond to spatial and seasonal trade-offs in precipitation, temperature, and solar radiation, which act as primary controls. We identify two SLA spatial gradients, which we attribute to the effect of spatially variable precipitation. Our results also reveal that aspect-related SLA differences vary seasonally and are influenced by solar radiation. In terms of seasonal dominant controls, we demonstrate that the snow line is controlled by snow precipitation in winter, melt in premonsoon, a combination of both in postmonsoon, and temperature in monsoon, explaining to a large extent the spatial and seasonal variability of the SLA in the upper Langtang Valley. We conclude that while SLA and snow-covered area are complementary metrics, the SLA has a strong potential for understanding local-scale snow cover dynamics and their controlling mechanisms.","lang":"eng"}],"publication_status":"published","_id":"12600","oa":1,"publication":"Water Resources Research","title":"High‐resolution snowline delineation from Landsat imagery to infer snow cover controls in a Himalayan catchment","year":"2019","quality_controlled":"1","author":[{"first_name":"Marc","last_name":"Girona‐Mata","full_name":"Girona‐Mata, Marc"},{"last_name":"Miles","first_name":"Evan S.","full_name":"Miles, Evan S."},{"full_name":"Ragettli, Silvan","first_name":"Silvan","last_name":"Ragettli"},{"full_name":"Pellicciotti, Francesca","id":"b28f055a-81ea-11ed-b70c-a9fe7f7b0e70","last_name":"Pellicciotti","first_name":"Francesca"}],"extern":"1","citation":{"ieee":"M. Girona‐Mata, E. S. Miles, S. Ragettli, and F. Pellicciotti, “High‐resolution snowline delineation from Landsat imagery to infer snow cover controls in a Himalayan catchment,” <i>Water Resources Research</i>, vol. 55, no. 8. American Geophysical Union, pp. 6754–6772, 2019.","ama":"Girona‐Mata M, Miles ES, Ragettli S, Pellicciotti F. High‐resolution snowline delineation from Landsat imagery to infer snow cover controls in a Himalayan catchment. <i>Water Resources Research</i>. 2019;55(8):6754-6772. doi:<a href=\"https://doi.org/10.1029/2019wr024935\">10.1029/2019wr024935</a>","chicago":"Girona‐Mata, Marc, Evan S. Miles, Silvan Ragettli, and Francesca Pellicciotti. “High‐resolution Snowline Delineation from Landsat Imagery to Infer Snow Cover Controls in a Himalayan Catchment.” <i>Water Resources Research</i>. American Geophysical Union, 2019. <a href=\"https://doi.org/10.1029/2019wr024935\">https://doi.org/10.1029/2019wr024935</a>.","short":"M. Girona‐Mata, E.S. Miles, S. Ragettli, F. Pellicciotti, Water Resources Research 55 (2019) 6754–6772.","ista":"Girona‐Mata M, Miles ES, Ragettli S, Pellicciotti F. 2019. High‐resolution snowline delineation from Landsat imagery to infer snow cover controls in a Himalayan catchment. Water Resources Research. 55(8), 6754–6772.","apa":"Girona‐Mata, M., Miles, E. S., Ragettli, S., &#38; Pellicciotti, F. (2019). High‐resolution snowline delineation from Landsat imagery to infer snow cover controls in a Himalayan catchment. <i>Water Resources Research</i>. American Geophysical Union. <a href=\"https://doi.org/10.1029/2019wr024935\">https://doi.org/10.1029/2019wr024935</a>","mla":"Girona‐Mata, Marc, et al. “High‐resolution Snowline Delineation from Landsat Imagery to Infer Snow Cover Controls in a Himalayan Catchment.” <i>Water Resources Research</i>, vol. 55, no. 8, American Geophysical Union, 2019, pp. 6754–72, doi:<a href=\"https://doi.org/10.1029/2019wr024935\">10.1029/2019wr024935</a>."},"main_file_link":[{"url":"https://doi.org/10.1029/2019WR024935","open_access":"1"}]},{"day":"01","type":"journal_article","date_updated":"2023-02-28T12:11:07Z","oa_version":"Published Version","article_processing_charge":"No","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","language":[{"iso":"eng"}],"doi":"10.1017/jog.2019.40","page":"617-632","date_published":"2019-08-01T00:00:00Z","publication_identifier":{"issn":["0022-1430"],"eissn":["1727-5652"]},"scopus_import":"1","year":"2019","quality_controlled":"1","extern":"1","author":[{"first_name":"JAKOB F.","last_name":"STEINER","full_name":"STEINER, JAKOB F."},{"full_name":"BURI, PASCAL","first_name":"PASCAL","last_name":"BURI"},{"full_name":"MILES, EVAN S.","first_name":"EVAN S.","last_name":"MILES"},{"first_name":"SILVAN","last_name":"RAGETTLI","full_name":"RAGETTLI, SILVAN"},{"id":"b28f055a-81ea-11ed-b70c-a9fe7f7b0e70","full_name":"Pellicciotti, Francesca","first_name":"Francesca","last_name":"Pellicciotti"}],"citation":{"short":"J.F. STEINER, P. BURI, E.S. MILES, S. RAGETTLI, F. Pellicciotti, Journal of Glaciology 65 (2019) 617–632.","chicago":"STEINER, JAKOB F., PASCAL BURI, EVAN S. MILES, SILVAN RAGETTLI, and Francesca Pellicciotti. “Supraglacial Ice Cliffs and Ponds on Debris-Covered Glaciers: Spatio-Temporal Distribution and Characteristics.” <i>Journal of Glaciology</i>. Cambridge University Press, 2019. <a href=\"https://doi.org/10.1017/jog.2019.40\">https://doi.org/10.1017/jog.2019.40</a>.","ista":"STEINER JF, BURI P, MILES ES, RAGETTLI S, Pellicciotti F. 2019. Supraglacial ice cliffs and ponds on debris-covered glaciers: Spatio-temporal distribution and characteristics. Journal of Glaciology. 65(252), 617–632.","ieee":"J. F. STEINER, P. BURI, E. S. MILES, S. RAGETTLI, and F. Pellicciotti, “Supraglacial ice cliffs and ponds on debris-covered glaciers: Spatio-temporal distribution and characteristics,” <i>Journal of Glaciology</i>, vol. 65, no. 252. Cambridge University Press, pp. 617–632, 2019.","ama":"STEINER JF, BURI P, MILES ES, RAGETTLI S, Pellicciotti F. Supraglacial ice cliffs and ponds on debris-covered glaciers: Spatio-temporal distribution and characteristics. <i>Journal of Glaciology</i>. 2019;65(252):617-632. doi:<a href=\"https://doi.org/10.1017/jog.2019.40\">10.1017/jog.2019.40</a>","apa":"STEINER, J. F., BURI, P., MILES, E. S., RAGETTLI, S., &#38; Pellicciotti, F. (2019). Supraglacial ice cliffs and ponds on debris-covered glaciers: Spatio-temporal distribution and characteristics. <i>Journal of Glaciology</i>. Cambridge University Press. <a href=\"https://doi.org/10.1017/jog.2019.40\">https://doi.org/10.1017/jog.2019.40</a>","mla":"STEINER, JAKOB F., et al. “Supraglacial Ice Cliffs and Ponds on Debris-Covered Glaciers: Spatio-Temporal Distribution and Characteristics.” <i>Journal of Glaciology</i>, vol. 65, no. 252, Cambridge University Press, 2019, pp. 617–32, doi:<a href=\"https://doi.org/10.1017/jog.2019.40\">10.1017/jog.2019.40</a>."},"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1017/jog.2019.40"}],"publication_status":"published","abstract":[{"text":"Ice cliffs and ponds on debris-covered glaciers have received increased attention due to their role in amplifying local melt. However, very few studies have looked at these features on the catchment scale to determine their patterns and changes in space and time. We have compiled a detailed inventory of cliffs and ponds in the Langtang catchment, central Himalaya, from six high-resolution satellite orthoimages and DEMs between 2006 and 2015, and a historic orthophoto from 1974. Cliffs cover between 1.4% (± 0.4%) in the dry and 3.4% (± 0.9%) in the wet seasons and ponds between 0.6% (± 0.1%) and 1.6% (± 0.3%) of the total debris-covered tongues. We find large variations between seasons, as cliffs and ponds tend to grow in the wetter monsoon period, but there is no obvious trend in total area over the study period. The inventory further shows that cliffs are predominately north-facing irrespective of the glacier flow direction. Both cliffs and ponds appear in higher densities several hundred metres from the terminus in areas where tributaries reach the main glacier tongue. On the largest glacier in the catchment ~10% of all cliffs and ponds persisted over nearly a decade.","lang":"eng"}],"oa":1,"_id":"12601","title":"Supraglacial ice cliffs and ponds on debris-covered glaciers: Spatio-temporal distribution and characteristics","publication":"Journal of Glaciology","article_type":"original","publisher":"Cambridge University Press","issue":"252","volume":65,"status":"public","date_created":"2023-02-20T08:13:03Z","month":"08","intvolume":"        65"},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_processing_charge":"No","oa_version":"Published Version","type":"journal_article","date_updated":"2023-02-28T12:04:48Z","day":"04","language":[{"iso":"eng"}],"doi":"10.3389/feart.2019.00143","date_published":"2019-06-04T00:00:00Z","scopus_import":"1","publication_identifier":{"issn":["2296-6463"]},"main_file_link":[{"open_access":"1","url":"https://doi.org/10.3389/feart.2019.00143"}],"citation":{"ista":"Wijngaard RR, Steiner JF, Kraaijenbrink PDA, Klug C, Adhikari S, Banerjee A, Pellicciotti F, van Beek LPH, Bierkens MFP, Lutz AF, Immerzeel WW. 2019. Modeling the response of the Langtang Glacier and the Hintereisferner to a changing climate since the Little Ice Age. Frontiers in Earth Science. 7, 143.","short":"R.R. Wijngaard, J.F. Steiner, P.D.A. Kraaijenbrink, C. Klug, S. Adhikari, A. Banerjee, F. Pellicciotti, L.P.H. van Beek, M.F.P. Bierkens, A.F. Lutz, W.W. Immerzeel, Frontiers in Earth Science 7 (2019).","chicago":"Wijngaard, René R., Jakob F. Steiner, Philip D. A. Kraaijenbrink, Christoph Klug, Surendra Adhikari, Argha Banerjee, Francesca Pellicciotti, et al. “Modeling the Response of the Langtang Glacier and the Hintereisferner to a Changing Climate since the Little Ice Age.” <i>Frontiers in Earth Science</i>. Frontiers Media, 2019. <a href=\"https://doi.org/10.3389/feart.2019.00143\">https://doi.org/10.3389/feart.2019.00143</a>.","ieee":"R. R. Wijngaard <i>et al.</i>, “Modeling the response of the Langtang Glacier and the Hintereisferner to a changing climate since the Little Ice Age,” <i>Frontiers in Earth Science</i>, vol. 7. Frontiers Media, 2019.","ama":"Wijngaard RR, Steiner JF, Kraaijenbrink PDA, et al. Modeling the response of the Langtang Glacier and the Hintereisferner to a changing climate since the Little Ice Age. <i>Frontiers in Earth Science</i>. 2019;7. doi:<a href=\"https://doi.org/10.3389/feart.2019.00143\">10.3389/feart.2019.00143</a>","apa":"Wijngaard, R. R., Steiner, J. F., Kraaijenbrink, P. D. A., Klug, C., Adhikari, S., Banerjee, A., … Immerzeel, W. W. (2019). Modeling the response of the Langtang Glacier and the Hintereisferner to a changing climate since the Little Ice Age. <i>Frontiers in Earth Science</i>. Frontiers Media. <a href=\"https://doi.org/10.3389/feart.2019.00143\">https://doi.org/10.3389/feart.2019.00143</a>","mla":"Wijngaard, René R., et al. “Modeling the Response of the Langtang Glacier and the Hintereisferner to a Changing Climate since the Little Ice Age.” <i>Frontiers in Earth Science</i>, vol. 7, 143, Frontiers Media, 2019, doi:<a href=\"https://doi.org/10.3389/feart.2019.00143\">10.3389/feart.2019.00143</a>."},"quality_controlled":"1","extern":"1","author":[{"full_name":"Wijngaard, René R.","last_name":"Wijngaard","first_name":"René R."},{"full_name":"Steiner, Jakob F.","first_name":"Jakob F.","last_name":"Steiner"},{"first_name":"Philip D. A.","last_name":"Kraaijenbrink","full_name":"Kraaijenbrink, Philip D. A."},{"full_name":"Klug, Christoph","last_name":"Klug","first_name":"Christoph"},{"full_name":"Adhikari, Surendra","first_name":"Surendra","last_name":"Adhikari"},{"first_name":"Argha","last_name":"Banerjee","full_name":"Banerjee, Argha"},{"id":"b28f055a-81ea-11ed-b70c-a9fe7f7b0e70","full_name":"Pellicciotti, Francesca","last_name":"Pellicciotti","first_name":"Francesca"},{"full_name":"van Beek, Ludovicus P. H.","first_name":"Ludovicus P. H.","last_name":"van Beek"},{"full_name":"Bierkens, Marc F. P.","first_name":"Marc F. P.","last_name":"Bierkens"},{"last_name":"Lutz","first_name":"Arthur F.","full_name":"Lutz, Arthur F."},{"full_name":"Immerzeel, Walter W.","first_name":"Walter W.","last_name":"Immerzeel"}],"year":"2019","publication":"Frontiers in Earth Science","title":"Modeling the response of the Langtang Glacier and the Hintereisferner to a changing climate since the Little Ice Age","_id":"12602","oa":1,"abstract":[{"text":"This study aims at developing and applying a spatially-distributed coupled glacier mass balance and ice-flow model to attribute the response of glaciers to natural and anthropogenic climate change. We focus on two glaciers with contrasting surface characteristics: a debris-covered glacier (Langtang Glacier in Nepal) and a clean-ice glacier (Hintereisferner in Austria). The model is applied from the end of the Little Ice Age (1850) to the present-day (2016) and is forced with four bias-corrected General Circulation Models (GCMs) from the historical experiment of the CMIP5 archive. The selected GCMs represent region-specific warm-dry, warm-wet, cold-dry, and cold-wet climate conditions. To isolate the effects of anthropogenic climate change on glacier mass balance and flow runs from these GCMs with and without further anthropogenic forcing after 1970 until 2016 are selected. The outcomes indicate that both glaciers experience the largest reduction in area and volume under warm climate conditions, whereas area and volume reductions are smaller under cold climate conditions. Simultaneously with changes in glacier area and volume, surface velocities generally decrease over time. Without further anthropogenic forcing the results reveal a 3% (9%) smaller decline in glacier area (volume) for the debris-covered glacier and a 18% (39%) smaller decline in glacier area (volume) for the clean-ice glacier. The difference in the magnitude between the two glaciers can mainly be attributed to differences in the response time of the glaciers, where the clean-ice glacier shows a much faster response to climate change. We conclude that the response of the two glaciers can mainly be attributed to anthropogenic climate change and that the impact is larger on the clean-ice glacier. The outcomes show that the model performs well under different climate conditions and that the developed approach can be used for regional-scale glacio-hydrological modeling.","lang":"eng"}],"publication_status":"published","volume":7,"article_type":"original","publisher":"Frontiers Media","intvolume":"         7","month":"06","date_created":"2023-02-20T08:13:08Z","article_number":"143","status":"public"},{"page":"25","file":[{"access_level":"open_access","file_name":"2019_AHPC_Schloegl.pdf","checksum":"acc8272027faaf30709c51ac5c58ffa4","file_id":"12970","date_updated":"2023-05-16T07:27:09Z","success":1,"creator":"dernst","content_type":"application/pdf","file_size":1097603,"date_created":"2023-05-16T07:27:09Z","relation":"main_file"}],"date_published":"2019-02-27T00:00:00Z","publisher":"Institut für Mathematik und wissenschaftliches Rechnen der Universität Graz","file_date_updated":"2023-05-16T07:27:09Z","status":"public","conference":{"end_date":"2019-02-27","name":"AHPC: Austrian HPC Meeting","location":"Grundlsee, Austria","start_date":"2019-02-25"},"month":"02","date_created":"2023-05-05T12:48:48Z","article_processing_charge":"No","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"id":"45BF87EE-F248-11E8-B48F-1D18A9856A87","full_name":"Schlögl, Alois","orcid":"0000-0002-5621-8100","first_name":"Alois","last_name":"Schlögl"},{"id":"3D3A06F8-F248-11E8-B48F-1D18A9856A87","full_name":"Kiss, Janos","first_name":"Janos","last_name":"Kiss"},{"id":"490F40CE-F248-11E8-B48F-1D18A9856A87","full_name":"Elefante, Stefano","first_name":"Stefano","last_name":"Elefante"}],"citation":{"apa":"Schlögl, A., Kiss, J., &#38; Elefante, S. (2019). Is Debian suitable for running an HPC Cluster? In <i>AHPC19 - Austrian HPC Meeting 2019 </i> (p. 25). Grundlsee, Austria: Institut für Mathematik und wissenschaftliches Rechnen der Universität Graz.","mla":"Schlögl, Alois, et al. “Is Debian Suitable for Running an HPC Cluster?” <i>AHPC19 - Austrian HPC Meeting 2019 </i>, Institut für Mathematik und wissenschaftliches Rechnen der Universität Graz, 2019, p. 25.","ista":"Schlögl A, Kiss J, Elefante S. 2019. Is Debian suitable for running an HPC Cluster? AHPC19 - Austrian HPC Meeting 2019 . AHPC: Austrian HPC Meeting, 25.","short":"A. Schlögl, J. Kiss, S. Elefante, in:, AHPC19 - Austrian HPC Meeting 2019 , Institut für Mathematik und wissenschaftliches Rechnen der Universität Graz, 2019, p. 25.","chicago":"Schlögl, Alois, Janos Kiss, and Stefano Elefante. “Is Debian Suitable for Running an HPC Cluster?” In <i>AHPC19 - Austrian HPC Meeting 2019 </i>, 25. Institut für Mathematik und wissenschaftliches Rechnen der Universität Graz, 2019.","ama":"Schlögl A, Kiss J, Elefante S. Is Debian suitable for running an HPC Cluster? In: <i>AHPC19 - Austrian HPC Meeting 2019 </i>. Institut für Mathematik und wissenschaftliches Rechnen der Universität Graz; 2019:25.","ieee":"A. Schlögl, J. Kiss, and S. Elefante, “Is Debian suitable for running an HPC Cluster?,” in <i>AHPC19 - Austrian HPC Meeting 2019 </i>, Grundlsee, Austria, 2019, p. 25."},"main_file_link":[{"url":"https://vsc.ac.at/fileadmin/user_upload/vsc/conferences/ahpc19/BOOKLET_AHPC19.pdf","open_access":"1"}],"year":"2019","day":"27","oa_version":"Published Version","date_updated":"2023-05-16T07:29:32Z","type":"conference_abstract","has_accepted_license":"1","_id":"12901","department":[{"_id":"ScienComp"}],"language":[{"iso":"eng"}],"ddc":["000"],"oa":1,"title":"Is Debian suitable for running an HPC Cluster?","publication":"AHPC19 - Austrian HPC Meeting 2019 ","publication_status":"published"},{"abstract":[{"text":"Genetic incompatibilities contribute to reproductive isolation between many diverging populations, but it is still unclear to what extent they play a role if divergence happens with gene flow. In contact zones between the \"Crab\" and \"Wave\" ecotypes of the snail Littorina saxatilis divergent selection forms strong barriers to gene flow, while the role of postzygotic barriers due to selection against hybrids remains unclear. High embryo abortion rates in this species could indicate the presence of such barriers. Postzygotic barriers might include genetic incompatibilities (e.g. Dobzhansky-Muller incompatibilities) but also maladaptation, both expected to be most pronounced in contact zones. In addition, embryo abortion might reflect physiological stress on females and embryos independent of any genetic stress. We examined all embryos of &gt;500 females sampled outside and inside contact zones of three populations in Sweden. Females' clutch size ranged from 0 to 1011 embryos (mean 130±123) and abortion rates varied between 0 and100% (mean 12%). We described female genotypes by using a hybrid index based on hundreds of SNPs differentiated between ecotypes with which we characterised female genotypes. We also calculated female SNP heterozygosity and inversion karyotype. Clutch size did not vary with female hybrid index and abortion rates were only weakly related to hybrid index in two sites but not at all in a third site. No additional variation in abortion rate was explained by female SNP heterozygosity, but increased female inversion heterozygosity added slightly to increased abortion. Our results show only weak and probably biologically insignificant postzygotic barriers contributing to ecotype divergence and the high and variable abortion rates were marginally, if at all, explained by hybrid index of females.","lang":"eng"}],"title":"Data from: Is embryo abortion a postzygotic barrier to gene flow between Littorina ecotypes?","related_material":{"record":[{"relation":"used_in_publication","status":"public","id":"7205"}]},"doi":"10.5061/DRYAD.TB2RBNZWK","ddc":["570"],"oa":1,"department":[{"_id":"NiBa"}],"_id":"13067","date_updated":"2023-09-06T14:48:57Z","tmp":{"short":"CC0 (1.0)","legal_code_url":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","name":"Creative Commons Public Domain Dedication (CC0 1.0)","image":"/images/cc_0.png"},"type":"research_data_reference","oa_version":"Published Version","day":"02","year":"2019","main_file_link":[{"open_access":"1","url":"https://doi.org/10.5061/dryad.tb2rbnzwk"}],"citation":{"apa":"Johannesson, K., Zagrodzka, Z., Faria, R., Westram, A. M., &#38; Butlin, R. (2019). Data from: Is embryo abortion a postzygotic barrier to gene flow between Littorina ecotypes? Dryad. <a href=\"https://doi.org/10.5061/DRYAD.TB2RBNZWK\">https://doi.org/10.5061/DRYAD.TB2RBNZWK</a>","mla":"Johannesson, Kerstin, et al. <i>Data from: Is Embryo Abortion a Postzygotic Barrier to Gene Flow between Littorina Ecotypes?</i> Dryad, 2019, doi:<a href=\"https://doi.org/10.5061/DRYAD.TB2RBNZWK\">10.5061/DRYAD.TB2RBNZWK</a>.","ama":"Johannesson K, Zagrodzka Z, Faria R, Westram AM, Butlin R. Data from: Is embryo abortion a postzygotic barrier to gene flow between Littorina ecotypes? 2019. doi:<a href=\"https://doi.org/10.5061/DRYAD.TB2RBNZWK\">10.5061/DRYAD.TB2RBNZWK</a>","ieee":"K. Johannesson, Z. Zagrodzka, R. Faria, A. M. Westram, and R. Butlin, “Data from: Is embryo abortion a postzygotic barrier to gene flow between Littorina ecotypes?” Dryad, 2019.","ista":"Johannesson K, Zagrodzka Z, Faria R, Westram AM, Butlin R. 2019. Data from: Is embryo abortion a postzygotic barrier to gene flow between Littorina ecotypes?, Dryad, <a href=\"https://doi.org/10.5061/DRYAD.TB2RBNZWK\">10.5061/DRYAD.TB2RBNZWK</a>.","chicago":"Johannesson, Kerstin, Zuzanna Zagrodzka, Rui Faria, Anja M Westram, and Roger Butlin. “Data from: Is Embryo Abortion a Postzygotic Barrier to Gene Flow between Littorina Ecotypes?” Dryad, 2019. <a href=\"https://doi.org/10.5061/DRYAD.TB2RBNZWK\">https://doi.org/10.5061/DRYAD.TB2RBNZWK</a>.","short":"K. Johannesson, Z. Zagrodzka, R. Faria, A.M. Westram, R. Butlin, (2019)."},"article_processing_charge":"No","author":[{"last_name":"Johannesson","first_name":"Kerstin","full_name":"Johannesson, Kerstin"},{"full_name":"Zagrodzka, Zuzanna","first_name":"Zuzanna","last_name":"Zagrodzka"},{"last_name":"Faria","first_name":"Rui","full_name":"Faria, Rui"},{"last_name":"Westram","first_name":"Anja M","id":"3C147470-F248-11E8-B48F-1D18A9856A87","full_name":"Westram, Anja M","orcid":"0000-0003-1050-4969"},{"full_name":"Butlin, Roger","first_name":"Roger","last_name":"Butlin"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2023-05-23T16:36:27Z","month":"12","status":"public","publisher":"Dryad","date_published":"2019-12-02T00:00:00Z"},{"date_published":"2019-10-28T00:00:00Z","publisher":"Dryad","status":"public","date_created":"2023-05-23T17:09:30Z","month":"10","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","extern":"1","author":[{"first_name":"Abigail","last_name":"Buchwalter","full_name":"Buchwalter, Abigail"},{"full_name":"Schulte, Roberta","first_name":"Roberta","last_name":"Schulte"},{"last_name":"Tsai","first_name":"Hsiao","full_name":"Tsai, Hsiao"},{"full_name":"Capitanio, Juliana","last_name":"Capitanio","first_name":"Juliana"},{"first_name":"Martin W","last_name":"HETZER","orcid":"0000-0002-2111-992X","full_name":"HETZER, Martin W","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed"}],"article_processing_charge":"No","main_file_link":[{"url":"https://doi.org/10.5061/dryad.n0r525h","open_access":"1"}],"citation":{"mla":"Buchwalter, Abigail, et al. <i>Data from: Selective Clearance of the Inner Nuclear Membrane Protein Emerin by Vesicular Transport during ER Stress</i>. Dryad, 2019, doi:<a href=\"https://doi.org/10.5061/DRYAD.N0R525H\">10.5061/DRYAD.N0R525H</a>.","apa":"Buchwalter, A., Schulte, R., Tsai, H., Capitanio, J., &#38; Hetzer, M. (2019). Data from: Selective clearance of the inner nuclear membrane protein emerin by vesicular transport during ER stress. Dryad. <a href=\"https://doi.org/10.5061/DRYAD.N0R525H\">https://doi.org/10.5061/DRYAD.N0R525H</a>","ista":"Buchwalter A, Schulte R, Tsai H, Capitanio J, Hetzer M. 2019. Data from: Selective clearance of the inner nuclear membrane protein emerin by vesicular transport during ER stress, Dryad, <a href=\"https://doi.org/10.5061/DRYAD.N0R525H\">10.5061/DRYAD.N0R525H</a>.","chicago":"Buchwalter, Abigail, Roberta Schulte, Hsiao Tsai, Juliana Capitanio, and Martin Hetzer. “Data from: Selective Clearance of the Inner Nuclear Membrane Protein Emerin by Vesicular Transport during ER Stress.” Dryad, 2019. <a href=\"https://doi.org/10.5061/DRYAD.N0R525H\">https://doi.org/10.5061/DRYAD.N0R525H</a>.","short":"A. Buchwalter, R. Schulte, H. Tsai, J. Capitanio, M. Hetzer, (2019).","ieee":"A. Buchwalter, R. Schulte, H. Tsai, J. Capitanio, and M. Hetzer, “Data from: Selective clearance of the inner nuclear membrane protein emerin by vesicular transport during ER stress.” Dryad, 2019.","ama":"Buchwalter A, Schulte R, Tsai H, Capitanio J, Hetzer M. Data from: Selective clearance of the inner nuclear membrane protein emerin by vesicular transport during ER stress. 2019. doi:<a href=\"https://doi.org/10.5061/DRYAD.N0R525H\">10.5061/DRYAD.N0R525H</a>"},"day":"28","year":"2019","tmp":{"short":"CC0 (1.0)","legal_code_url":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","name":"Creative Commons Public Domain Dedication (CC0 1.0)","image":"/images/cc_0.png"},"date_updated":"2023-05-31T06:36:23Z","type":"research_data_reference","oa_version":"Published Version","ddc":["570"],"oa":1,"related_material":{"record":[{"status":"public","relation":"used_in_publication","id":"11060"}]},"doi":"10.5061/DRYAD.N0R525H","_id":"13079","title":"Data from: Selective clearance of the inner nuclear membrane protein emerin by vesicular transport during ER stress","abstract":[{"lang":"eng","text":"The inner nuclear membrane (INM) is a subdomain of the endoplasmic reticulum (ER) that is gated by the nuclear pore complex. It is unknown whether proteins of the INM and ER are degraded through shared or distinct pathways in mammalian cells. We applied dynamic proteomics to profile protein half-lives and report that INM and ER residents turn over at similar rates, indicating that the INM’s unique topology is not a barrier to turnover. Using a microscopy approach, we observed that the proteasome can degrade INM proteins in situ. However, we also uncovered evidence for selective, vesicular transport-mediated turnover of a single INM protein, emerin, that is potentiated by ER stress. Emerin is rapidly cleared from the INM by a mechanism that requires emerin’s LEM domain to mediate vesicular trafficking to lysosomes. This work demonstrates that the INM can be dynamically remodeled in response to environmental inputs."}]},{"month":"10","date_created":"2020-08-10T11:50:42Z","status":"public","intvolume":"        74","publication_identifier":{"issn":["0105-4538","1398-9995"]},"article_type":"letter_note","publisher":"Wiley","date_published":"2019-10-01T00:00:00Z","issue":"10","page":"1985-1989","volume":74,"publication_status":"published","publication":"Allergy","title":"AllergoOncology: Expression platform development and functional profiling of an anti‐HER2 IgE antibody","_id":"8227","oa":1,"language":[{"iso":"eng"}],"doi":"10.1111/all.13818","oa_version":"Published Version","type":"journal_article","date_updated":"2021-01-12T08:17:35Z","year":"2019","day":"01","main_file_link":[{"url":"https://doi.org/10.1111/all.13818","open_access":"1"}],"citation":{"ieee":"K. M. Ilieva <i>et al.</i>, “AllergoOncology: Expression platform development and functional profiling of an anti‐HER2 IgE antibody,” <i>Allergy</i>, vol. 74, no. 10. Wiley, pp. 1985–1989, 2019.","ama":"Ilieva KM, Singer J, Bax HJ, et al. AllergoOncology: Expression platform development and functional profiling of an anti‐HER2 IgE antibody. <i>Allergy</i>. 2019;74(10):1985-1989. doi:<a href=\"https://doi.org/10.1111/all.13818\">10.1111/all.13818</a>","ista":"Ilieva KM, Singer J, Bax HJ, Crescioli S, Montero‐Morales L, Mele S, Sow HS, Stavraka C, Josephs DH, Spicer JF, Steinkellner H, Jensen‐Jarolim E, Tutt ANJ, Karagiannis SN. 2019. AllergoOncology: Expression platform development and functional profiling of an anti‐HER2 IgE antibody. Allergy. 74(10), 1985–1989.","short":"K.M. Ilieva, J. Singer, H.J. Bax, S. Crescioli, L. Montero‐Morales, S. Mele, H.S. Sow, C. Stavraka, D.H. Josephs, J.F. Spicer, H. Steinkellner, E. Jensen‐Jarolim, A.N.J. Tutt, S.N. Karagiannis, Allergy 74 (2019) 1985–1989.","chicago":"Ilieva, Kristina M., Judit Singer, Heather J. Bax, Silvia Crescioli, Laura Montero‐Morales, Silvia Mele, Heng Sheng Sow, et al. “AllergoOncology: Expression Platform Development and Functional Profiling of an Anti‐HER2 IgE Antibody.” <i>Allergy</i>. Wiley, 2019. <a href=\"https://doi.org/10.1111/all.13818\">https://doi.org/10.1111/all.13818</a>.","apa":"Ilieva, K. M., Singer, J., Bax, H. J., Crescioli, S., Montero‐Morales, L., Mele, S., … Karagiannis, S. N. (2019). AllergoOncology: Expression platform development and functional profiling of an anti‐HER2 IgE antibody. <i>Allergy</i>. Wiley. <a href=\"https://doi.org/10.1111/all.13818\">https://doi.org/10.1111/all.13818</a>","mla":"Ilieva, Kristina M., et al. “AllergoOncology: Expression Platform Development and Functional Profiling of an Anti‐HER2 IgE Antibody.” <i>Allergy</i>, vol. 74, no. 10, Wiley, 2019, pp. 1985–89, doi:<a href=\"https://doi.org/10.1111/all.13818\">10.1111/all.13818</a>."},"article_processing_charge":"No","extern":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","quality_controlled":"1","author":[{"first_name":"Kristina M.","last_name":"Ilieva","full_name":"Ilieva, Kristina M."},{"first_name":"Judit","last_name":"Fazekas-Singer","orcid":"0000-0002-8777-3502","full_name":"Fazekas-Singer, Judit","id":"36432834-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Bax, Heather J.","last_name":"Bax","first_name":"Heather J."},{"last_name":"Crescioli","first_name":"Silvia","full_name":"Crescioli, Silvia"},{"last_name":"Montero‐Morales","first_name":"Laura","full_name":"Montero‐Morales, Laura"},{"last_name":"Mele","first_name":"Silvia","full_name":"Mele, Silvia"},{"last_name":"Sow","first_name":"Heng Sheng","full_name":"Sow, Heng Sheng"},{"first_name":"Chara","last_name":"Stavraka","full_name":"Stavraka, Chara"},{"full_name":"Josephs, Debra H.","last_name":"Josephs","first_name":"Debra H."},{"first_name":"James F.","last_name":"Spicer","full_name":"Spicer, James F."},{"last_name":"Steinkellner","first_name":"Herta","full_name":"Steinkellner, Herta","orcid":"0000-0003-4823-1505"},{"full_name":"Jensen‐Jarolim, Erika","orcid":"0000-0003-4019-5765","first_name":"Erika","last_name":"Jensen‐Jarolim"},{"first_name":"Andrew N. J.","last_name":"Tutt","full_name":"Tutt, Andrew N. J.","orcid":"0000-0001-8715-2901"},{"full_name":"Karagiannis, Sophia N.","orcid":"0000-0002-4100-7810","last_name":"Karagiannis","first_name":"Sophia N."}]},{"publication_identifier":{"issn":["1939-4551"]},"date_published":"2019-07-29T00:00:00Z","doi":"10.1016/j.waojou.2019.100044","language":[{"iso":"eng"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_processing_charge":"No","oa_version":"Published Version","type":"journal_article","date_updated":"2021-01-12T08:17:36Z","day":"29","intvolume":"        12","month":"07","date_created":"2020-08-10T11:50:54Z","article_number":"100044","status":"public","issue":"7","volume":12,"publisher":"Elsevier","article_type":"original","title":"AllergoOncology: High innate IgE levels are decisive for the survival of cancer-bearing mice","publication":"World Allergy Organization Journal","_id":"8228","oa":1,"abstract":[{"text":"Background: Atopics have a lower risk for malignancies, and IgE targeted to tumors is superior to IgG in fighting cancer. Whether IgE-mediated innate or adaptive immune surveillance can confer protection against tumors remains unclear.\r\nObjective: We aimed to investigate the effects of active and passive immunotherapy to the tumor-associated antigen HER-2 in three murine models differing in Epsilon-B-cell-receptor expression affecting the levels of expressed IgE.\r\nMethods: We compared the levels of several serum specific anti-HER-2 antibodies (IgE, IgG1, IgG2a, IgG2b, IgA) and the survival rates in low-IgE ΔM1M2 mice lacking the transmembrane/cytoplasmic domain of Epsilon-B-cell-receptors expressing reduced IgE levels, high-IgE KN1 mice expressing chimeric Epsilon-Gamma1-B-cell receptors with 4-6-fold elevated serum IgE levels, and wild type (WT) BALB/c. Prior engrafting mice with D2F2/E2 mammary tumors overexpressing HER-2, mice were vaccinated with HER-2 or vehicle control PBS using the Th2-adjuvant Al(OH)3 (active immunotherapy), or treated with the murine anti-HER-2 IgG1 antibody 4D5 (passive immunotherapy).\r\nResults: Overall, among the three strains of mice, HER-2 vaccination induced significantly higher levels of HER-2 specific IgE and IgG1 in high-IgE KN1, while low-IgE ΔM1M2 mice had higher IgG2a levels. HER-2 vaccination and passive immunotherapy prolonged the survival in tumor-grafted WT and low-IgE ΔM1M2 strains compared with treatment controls; active vaccination provided the highest benefit. Notably, untreated high-IgE KN1 mice displayed the longest survival of all strains, which could not be further extended by active or passive immunotherapy.\r\nConclusion: Active and passive immunotherapies prolong survival in wild type and low-IgE ΔM1M2 mice engrafted with mammary tumors. High-IgE KN1 mice have an innate survival benefit following tumor challenge.","lang":"eng"}],"publication_status":"published","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1016/j.waojou.2019.100044"}],"citation":{"ista":"Singer J, Achatz-Straussberger G, Bentley-Lukschal A, Singer J, Achatz G, Karagiannis SN, Jensen-Jarolim E. 2019. AllergoOncology: High innate IgE levels are decisive for the survival of cancer-bearing mice. World Allergy Organization Journal. 12(7), 100044.","chicago":"Singer, Josef, Gertrude Achatz-Straussberger, Anna Bentley-Lukschal, Judit Singer, Gernot Achatz, Sophia N. Karagiannis, and Erika Jensen-Jarolim. “AllergoOncology: High Innate IgE Levels Are Decisive for the Survival of Cancer-Bearing Mice.” <i>World Allergy Organization Journal</i>. Elsevier, 2019. <a href=\"https://doi.org/10.1016/j.waojou.2019.100044\">https://doi.org/10.1016/j.waojou.2019.100044</a>.","short":"J. Singer, G. Achatz-Straussberger, A. Bentley-Lukschal, J. Singer, G. Achatz, S.N. Karagiannis, E. Jensen-Jarolim, World Allergy Organization Journal 12 (2019).","ieee":"J. Singer <i>et al.</i>, “AllergoOncology: High innate IgE levels are decisive for the survival of cancer-bearing mice,” <i>World Allergy Organization Journal</i>, vol. 12, no. 7. Elsevier, 2019.","ama":"Singer J, Achatz-Straussberger G, Bentley-Lukschal A, et al. AllergoOncology: High innate IgE levels are decisive for the survival of cancer-bearing mice. <i>World Allergy Organization Journal</i>. 2019;12(7). doi:<a href=\"https://doi.org/10.1016/j.waojou.2019.100044\">10.1016/j.waojou.2019.100044</a>","apa":"Singer, J., Achatz-Straussberger, G., Bentley-Lukschal, A., Singer, J., Achatz, G., Karagiannis, S. N., &#38; Jensen-Jarolim, E. (2019). AllergoOncology: High innate IgE levels are decisive for the survival of cancer-bearing mice. <i>World Allergy Organization Journal</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.waojou.2019.100044\">https://doi.org/10.1016/j.waojou.2019.100044</a>","mla":"Singer, Josef, et al. “AllergoOncology: High Innate IgE Levels Are Decisive for the Survival of Cancer-Bearing Mice.” <i>World Allergy Organization Journal</i>, vol. 12, no. 7, 100044, Elsevier, 2019, doi:<a href=\"https://doi.org/10.1016/j.waojou.2019.100044\">10.1016/j.waojou.2019.100044</a>."},"author":[{"full_name":"Singer, Josef","orcid":"0000-0002-8701-2412","last_name":"Singer","first_name":"Josef"},{"full_name":"Achatz-Straussberger, Gertrude","first_name":"Gertrude","last_name":"Achatz-Straussberger"},{"first_name":"Anna","last_name":"Bentley-Lukschal","full_name":"Bentley-Lukschal, Anna"},{"id":"36432834-F248-11E8-B48F-1D18A9856A87","full_name":"Fazekas-Singer, Judit","orcid":"0000-0002-8777-3502","first_name":"Judit","last_name":"Fazekas-Singer"},{"first_name":"Gernot","last_name":"Achatz","full_name":"Achatz, Gernot"},{"full_name":"Karagiannis, Sophia N.","first_name":"Sophia N.","last_name":"Karagiannis"},{"full_name":"Jensen-Jarolim, Erika","last_name":"Jensen-Jarolim","first_name":"Erika"}],"extern":"1","quality_controlled":"1","year":"2019"},{"year":"2019","extern":"1","quality_controlled":"1","author":[{"orcid":"0000-0001-7625-3651","full_name":"Ondracek, Anna S.","last_name":"Ondracek","first_name":"Anna S."},{"full_name":"Heiden, Denise","last_name":"Heiden","first_name":"Denise"},{"full_name":"Oostingh, Gertie J.","last_name":"Oostingh","first_name":"Gertie J."},{"first_name":"Elisabeth","last_name":"Fuerst","full_name":"Fuerst, Elisabeth"},{"last_name":"Fazekas-Singer","first_name":"Judit","id":"36432834-F248-11E8-B48F-1D18A9856A87","full_name":"Fazekas-Singer, Judit","orcid":"0000-0002-8777-3502"},{"full_name":"Bergmayr, Cornelia","first_name":"Cornelia","last_name":"Bergmayr"},{"first_name":"Johanna","last_name":"Rohrhofer","orcid":"0000-0002-2783-2099","full_name":"Rohrhofer, Johanna"},{"full_name":"Jensen-Jarolim, Erika","orcid":"0000-0003-4019-5765","last_name":"Jensen-Jarolim","first_name":"Erika"},{"full_name":"Duschl, Albert","orcid":"0000-0002-7034-9860","first_name":"Albert","last_name":"Duschl"},{"full_name":"Untersmayr, Eva","orcid":"0000-0002-1963-499X","last_name":"Untersmayr","first_name":"Eva"}],"main_file_link":[{"open_access":"1","url":"https://doi.org/10.3390/nu11102463"}],"citation":{"short":"A.S. Ondracek, D. Heiden, G.J. Oostingh, E. Fuerst, J. Singer, C. Bergmayr, J. Rohrhofer, E. Jensen-Jarolim, A. Duschl, E. Untersmayr, Nutrients 11 (2019).","chicago":"Ondracek, Anna S., Denise Heiden, Gertie J. Oostingh, Elisabeth Fuerst, Judit Singer, Cornelia Bergmayr, Johanna Rohrhofer, Erika Jensen-Jarolim, Albert Duschl, and Eva Untersmayr. “Immune Effects of the Nitrated Food Allergen Beta-Lactoglobulin in an Experimental Food Allergy Model.” <i>Nutrients</i>. MDPI, 2019. <a href=\"https://doi.org/10.3390/nu11102463\">https://doi.org/10.3390/nu11102463</a>.","ista":"Ondracek AS, Heiden D, Oostingh GJ, Fuerst E, Singer J, Bergmayr C, Rohrhofer J, Jensen-Jarolim E, Duschl A, Untersmayr E. 2019. Immune effects of the nitrated food allergen beta-lactoglobulin in an experimental food allergy model. Nutrients. 11(10), 2463.","ieee":"A. S. Ondracek <i>et al.</i>, “Immune effects of the nitrated food allergen beta-lactoglobulin in an experimental food allergy model,” <i>Nutrients</i>, vol. 11, no. 10. MDPI, 2019.","ama":"Ondracek AS, Heiden D, Oostingh GJ, et al. Immune effects of the nitrated food allergen beta-lactoglobulin in an experimental food allergy model. <i>Nutrients</i>. 2019;11(10). doi:<a href=\"https://doi.org/10.3390/nu11102463\">10.3390/nu11102463</a>","mla":"Ondracek, Anna S., et al. “Immune Effects of the Nitrated Food Allergen Beta-Lactoglobulin in an Experimental Food Allergy Model.” <i>Nutrients</i>, vol. 11, no. 10, 2463, MDPI, 2019, doi:<a href=\"https://doi.org/10.3390/nu11102463\">10.3390/nu11102463</a>.","apa":"Ondracek, A. S., Heiden, D., Oostingh, G. J., Fuerst, E., Singer, J., Bergmayr, C., … Untersmayr, E. (2019). Immune effects of the nitrated food allergen beta-lactoglobulin in an experimental food allergy model. <i>Nutrients</i>. MDPI. <a href=\"https://doi.org/10.3390/nu11102463\">https://doi.org/10.3390/nu11102463</a>"},"abstract":[{"text":"Food proteins may get nitrated by various exogenous or endogenous mechanisms. As individuals might get recurrently exposed to nitrated proteins via daily diet, we aimed to investigate the effect of repeatedly ingested nitrated food proteins on the subsequent immune response in non-allergic and allergic mice using the milk allergen beta-lactoglobulin (BLG) as model food protein in a mouse model. Evaluating the presence of nitrated proteins in food, we could detect 3-nitrotyrosine (3-NT) in extracts of different foods and in stomach content extracts of non-allergic mice under physiological conditions. Chemically nitrated BLG (BLGn) exhibited enhanced susceptibility to degradation in simulated gastric fluid experiments compared to untreated BLG (BLGu). Gavage of BLGn to non-allergic animals increased interferon-γ and interleukin-10 release of stimulated spleen cells and led to the formation of BLG-specific serum IgA. Allergic mice receiving three oral gavages of BLGn had higher levels of mouse mast cell protease-1 (mMCP-1) compared to allergic mice receiving BLGu. Regardless of the preceding immune status, non-allergic or allergic, repeatedly ingested nitrated food proteins seem to considerably influence the subsequent immune response.","lang":"eng"}],"publication_status":"published","_id":"8229","oa":1,"publication":"Nutrients","title":"Immune effects of the nitrated food allergen beta-lactoglobulin in an experimental food allergy model","article_type":"original","publisher":"MDPI","volume":11,"issue":"10","article_number":"2463","status":"public","month":"10","date_created":"2020-08-10T11:51:04Z","intvolume":"        11","day":"15","oa_version":"Published Version","date_updated":"2021-01-12T08:17:36Z","type":"journal_article","article_processing_charge":"No","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","doi":"10.3390/nu11102463","language":[{"iso":"eng"}],"date_published":"2019-10-15T00:00:00Z","publication_identifier":{"issn":["2072-6643"]}},{"oa_version":"Published Version","date_updated":"2023-02-23T13:28:54Z","type":"journal_article","year":"2019","day":"27","citation":{"mla":"Shelyakin, Pavel V., et al. “Micro-Evolution of Three Streptococcus Species: Selection, Antigenic Variation, and Horizontal Gene Inflow.” <i>BMC Evolutionary Biology</i>, vol. 19, 83, Springer Nature, 2019, doi:<a href=\"https://doi.org/10.1186/s12862-019-1403-6\">10.1186/s12862-019-1403-6</a>.","apa":"Shelyakin, P. V., Bochkareva, O., Karan, A. A., &#38; Gelfand, M. S. (2019). Micro-evolution of three Streptococcus species: Selection, antigenic variation, and horizontal gene inflow. <i>BMC Evolutionary Biology</i>. Springer Nature. <a href=\"https://doi.org/10.1186/s12862-019-1403-6\">https://doi.org/10.1186/s12862-019-1403-6</a>","ieee":"P. V. Shelyakin, O. Bochkareva, A. A. Karan, and M. S. Gelfand, “Micro-evolution of three Streptococcus species: Selection, antigenic variation, and horizontal gene inflow,” <i>BMC Evolutionary Biology</i>, vol. 19. Springer Nature, 2019.","ama":"Shelyakin PV, Bochkareva O, Karan AA, Gelfand MS. Micro-evolution of three Streptococcus species: Selection, antigenic variation, and horizontal gene inflow. <i>BMC Evolutionary Biology</i>. 2019;19. doi:<a href=\"https://doi.org/10.1186/s12862-019-1403-6\">10.1186/s12862-019-1403-6</a>","ista":"Shelyakin PV, Bochkareva O, Karan AA, Gelfand MS. 2019. Micro-evolution of three Streptococcus species: Selection, antigenic variation, and horizontal gene inflow. BMC Evolutionary Biology. 19, 83.","short":"P.V. Shelyakin, O. Bochkareva, A.A. Karan, M.S. Gelfand, BMC Evolutionary Biology 19 (2019).","chicago":"Shelyakin, Pavel V., Olga Bochkareva, Anna A. Karan, and Mikhail S. Gelfand. “Micro-Evolution of Three Streptococcus Species: Selection, Antigenic Variation, and Horizontal Gene Inflow.” <i>BMC Evolutionary Biology</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1186/s12862-019-1403-6\">https://doi.org/10.1186/s12862-019-1403-6</a>."},"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1186/s12862-019-1403-6"}],"extern":"1","quality_controlled":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"first_name":"Pavel V.","last_name":"Shelyakin","orcid":"0000-0003-0120-9319","full_name":"Shelyakin, Pavel V."},{"first_name":"Olga","last_name":"Bochkareva","full_name":"Bochkareva, Olga","orcid":"0000-0003-1006-6639","id":"C4558D3C-6102-11E9-A62E-F418E6697425"},{"first_name":"Anna A.","last_name":"Karan","full_name":"Karan, Anna A."},{"full_name":"Gelfand, Mikhail S.","last_name":"Gelfand","first_name":"Mikhail S."}],"article_processing_charge":"No","abstract":[{"lang":"eng","text":"Background: The genus Streptococcus comprises pathogens that strongly influence the health of humans and animals. Genome sequencing of multiple Streptococcus strains demonstrated high variability in gene content and order even in closely related strains of the same species and created a newly emerged object for genomic analysis, the pan-genome. Here we analysed the genome evolution of 25 strains of Streptococcus suis, 50 strains of Streptococcus pyogenes and 28 strains of Streptococcus pneumoniae.\r\n\r\nResults: Fractions of the pan-genome, unique, periphery, and universal genes differ in size, functional composition, the level of nucleotide substitutions, and predisposition to horizontal gene transfer and genomic rearrangements. The density of substitutions in intergenic regions appears to be correlated with selection acting on adjacent genes, implying that more conserved genes tend to have more conserved regulatory regions.\r\nThe total pan-genome of the genus is open, but only due to strain-specific genes, whereas other pan-genome fractions reach saturation. We have identified the set of genes with phylogenies inconsistent with species and non-conserved location in the chromosome; these genes are rare in at least one species and have likely experienced recent horizontal transfer between species. The strain-specific fraction is enriched with mobile elements and hypothetical proteins, but also contains a number of candidate virulence-related genes, so it may have a strong impact on adaptability and pathogenicity.\r\nMapping the rearrangements to the phylogenetic tree revealed large parallel inversions in all species. A parallel inversion of length 15 kB with breakpoints formed by genes encoding surface antigen proteins PhtD and PhtB in S. pneumoniae leads to replacement of gene fragments that likely indicates the action of an antigen variation mechanism.\r\n\r\nConclusions: Members of genus Streptococcus have a highly dynamic, open pan-genome, that potentially confers them with the ability to adapt to changing environmental conditions, i.e. antibiotic resistance or transmission between different hosts. Hence, integrated analysis of all aspects of genome evolution is important for the identification of potential pathogens and design of drugs and vaccines."}],"publication_status":"published","publication":"BMC Evolutionary Biology","title":"Micro-evolution of three Streptococcus species: Selection, antigenic variation, and horizontal gene inflow","_id":"8263","language":[{"iso":"eng"}],"oa":1,"doi":"10.1186/s12862-019-1403-6","article_type":"original","publisher":"Springer Nature","date_published":"2019-03-27T00:00:00Z","volume":19,"month":"03","date_created":"2020-08-15T11:04:07Z","article_number":"83","status":"public","intvolume":"        19","publication_identifier":{"issn":["1471-2148"]}},{"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","article_processing_charge":"No","day":"29","type":"book_chapter","date_updated":"2023-09-08T11:24:15Z","oa_version":"None","language":[{"iso":"eng"}],"doi":"10.1002/9781119487845.ch4","department":[{"_id":"NiBa"}],"edition":"4","page":"115-144","date_published":"2019-07-29T00:00:00Z","external_id":{"isi":["000261343000003"]},"publication_identifier":{"isbn":["9781119429142"]},"quality_controlled":"1","author":[{"orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","last_name":"Barton","first_name":"Nicholas H"},{"full_name":"Etheridge, Alison","first_name":"Alison","last_name":"Etheridge"}],"citation":{"apa":"Barton, N. H., &#38; Etheridge, A. (2019). Mathematical models in population genetics. In D. Balding, I. Moltke, &#38; J. Marioni (Eds.), <i>Handbook of statistical genomics</i> (4th ed., pp. 115–144). Wiley. <a href=\"https://doi.org/10.1002/9781119487845.ch4\">https://doi.org/10.1002/9781119487845.ch4</a>","mla":"Barton, Nicholas H., and Alison Etheridge. “Mathematical Models in Population Genetics.” <i>Handbook of Statistical Genomics</i>, edited by David Balding et al., 4th ed., Wiley, 2019, pp. 115–44, doi:<a href=\"https://doi.org/10.1002/9781119487845.ch4\">10.1002/9781119487845.ch4</a>.","chicago":"Barton, Nicholas H, and Alison Etheridge. “Mathematical Models in Population Genetics.” In <i>Handbook of Statistical Genomics</i>, edited by David Balding, Ida Moltke, and John Marioni, 4th ed., 115–44. Wiley, 2019. <a href=\"https://doi.org/10.1002/9781119487845.ch4\">https://doi.org/10.1002/9781119487845.ch4</a>.","short":"N.H. Barton, A. Etheridge, in:, D. Balding, I. Moltke, J. Marioni (Eds.), Handbook of Statistical Genomics, 4th ed., Wiley, 2019, pp. 115–144.","ista":"Barton NH, Etheridge A. 2019.Mathematical models in population genetics. In: Handbook of statistical genomics. , 115–144.","ieee":"N. H. Barton and A. Etheridge, “Mathematical models in population genetics,” in <i>Handbook of statistical genomics</i>, 4th ed., D. Balding, I. Moltke, and J. Marioni, Eds. Wiley, 2019, pp. 115–144.","ama":"Barton NH, Etheridge A. Mathematical models in population genetics. In: Balding D, Moltke I, Marioni J, eds. <i>Handbook of Statistical Genomics</i>. 4th ed. Wiley; 2019:115-144. doi:<a href=\"https://doi.org/10.1002/9781119487845.ch4\">10.1002/9781119487845.ch4</a>"},"year":"2019","ddc":["576"],"_id":"8281","title":"Mathematical models in population genetics","publication":"Handbook of statistical genomics","publication_status":"published","abstract":[{"lang":"eng","text":"We review the history of population genetics, starting with its origins a century ago from the synthesis between Mendel and Darwin's ideas, through to the recent development of sophisticated schemes of inference from sequence data, based on the coalescent. We explain the close relation between the coalescent and a diffusion process, which we illustrate by their application to understand spatial structure. We summarise the powerful methods available for analysis of multiple loci, when linkage equilibrium can be assumed, and then discuss approaches to the more challenging case, where associations between alleles require that we follow genotype, rather than allele, frequencies. Though we can hardly cover the whole of population genetics, we give an overview of the current state of the subject, and future challenges to it."}],"publisher":"Wiley","editor":[{"last_name":"Balding","first_name":"David","full_name":"Balding, David"},{"full_name":"Moltke, Ida","first_name":"Ida","last_name":"Moltke"},{"first_name":"John","last_name":"Marioni","full_name":"Marioni, John"}],"isi":1,"status":"public","date_created":"2020-08-21T04:25:39Z","month":"07"}]