[{"issue":"7","abstract":[{"lang":"eng","text":"The front cover artwork is provided by the group of Dr. Bartholomäus Pieber at the Max Planck Institute of Colloids and Interfaces (Germany). The image symbolizes the activation of a heterogeneous photocatalyst by visible light and its application for organic synthesis. Read the full text of the Review at 10.1002/cptc.202000014."}],"page":"454-454","doi":"10.1002/cptc.202000137","extern":"1","publication":"ChemPhotoChem","publisher":"Wiley","day":"01","title":"Heterogeneous photocatalysis in organic synthesis","citation":{"ama":"Gisbertz S, Pieber B. Heterogeneous photocatalysis in organic synthesis. ChemPhotoChem. 2020;4(7):454-454. doi:10.1002/cptc.202000137","ieee":"S. Gisbertz and B. Pieber, “Heterogeneous photocatalysis in organic synthesis,” ChemPhotoChem, vol. 4, no. 7. Wiley, pp. 454–454, 2020.","ista":"Gisbertz S, Pieber B. 2020. Heterogeneous photocatalysis in organic synthesis. ChemPhotoChem. 4(7), 454–454.","mla":"Gisbertz, Sebastian, and Bartholomäus Pieber. “Heterogeneous Photocatalysis in Organic Synthesis.” ChemPhotoChem, vol. 4, no. 7, Wiley, 2020, pp. 454–454, doi:10.1002/cptc.202000137.","short":"S. Gisbertz, B. Pieber, ChemPhotoChem 4 (2020) 454–454.","apa":"Gisbertz, S., & Pieber, B. (2020). Heterogeneous photocatalysis in organic synthesis. ChemPhotoChem. Wiley. https://doi.org/10.1002/cptc.202000137","chicago":"Gisbertz, Sebastian, and Bartholomäus Pieber. “Heterogeneous Photocatalysis in Organic Synthesis.” ChemPhotoChem. Wiley, 2020. https://doi.org/10.1002/cptc.202000137."},"article_type":"original","_id":"11966","oa_version":"None","status":"public","language":[{"iso":"eng"}],"publication_status":"published","intvolume":" 4","month":"07","article_processing_charge":"No","quality_controlled":"1","author":[{"first_name":"Sebastian","full_name":"Gisbertz, Sebastian","last_name":"Gisbertz"},{"first_name":"Bartholomäus","full_name":"Pieber, Bartholomäus","orcid":"0000-0001-8689-388X","last_name":"Pieber","id":"93e5e5b2-0da6-11ed-8a41-af589a024726"}],"date_published":"2020-07-01T00:00:00Z","date_created":"2022-08-25T08:33:38Z","type":"journal_article","volume":4,"publication_identifier":{"eissn":["2367-0932"]},"year":"2020","scopus_import":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2023-02-21T10:09:40Z"},{"oa":1,"year":"2020","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2023-02-21T10:09:47Z","scopus_import":"1","date_published":"2020-03-15T00:00:00Z","type":"journal_article","date_created":"2022-08-25T08:49:25Z","publication_identifier":{"issn":["1434-193X"],"eissn":["1099-0690"]},"volume":2020,"article_processing_charge":"No","quality_controlled":"1","author":[{"full_name":"Cavedon, Cristian","first_name":"Cristian","last_name":"Cavedon"},{"last_name":"Seeberger","full_name":"Seeberger, Peter H.","first_name":"Peter H."},{"first_name":"Bartholomäus","orcid":"0000-0001-8689-388X","full_name":"Pieber, Bartholomäus","last_name":"Pieber","id":"93e5e5b2-0da6-11ed-8a41-af589a024726"}],"article_type":"review","status":"public","oa_version":"Published Version","_id":"11969","publication_status":"published","intvolume":" 2020","month":"03","language":[{"iso":"eng"}],"publisher":"Wiley","publication":"European Journal of Organic Chemistry","main_file_link":[{"url":"https://doi.org/10.1002/ejoc.201901173","open_access":"1"}],"day":"15","title":"Photochemical strategies for carbon–heteroatom bond formation","citation":{"ieee":"C. Cavedon, P. H. Seeberger, and B. Pieber, “Photochemical strategies for carbon–heteroatom bond formation,” European Journal of Organic Chemistry, vol. 2020, no. 10. Wiley, pp. 1379–1392, 2020.","ama":"Cavedon C, Seeberger PH, Pieber B. Photochemical strategies for carbon–heteroatom bond formation. European Journal of Organic Chemistry. 2020;2020(10):1379-1392. doi:10.1002/ejoc.201901173","ista":"Cavedon C, Seeberger PH, Pieber B. 2020. Photochemical strategies for carbon–heteroatom bond formation. European Journal of Organic Chemistry. 2020(10), 1379–1392.","apa":"Cavedon, C., Seeberger, P. H., & Pieber, B. (2020). Photochemical strategies for carbon–heteroatom bond formation. European Journal of Organic Chemistry. Wiley. https://doi.org/10.1002/ejoc.201901173","short":"C. Cavedon, P.H. Seeberger, B. Pieber, European Journal of Organic Chemistry 2020 (2020) 1379–1392.","mla":"Cavedon, Cristian, et al. “Photochemical Strategies for Carbon–Heteroatom Bond Formation.” European Journal of Organic Chemistry, vol. 2020, no. 10, Wiley, 2020, pp. 1379–92, doi:10.1002/ejoc.201901173.","chicago":"Cavedon, Cristian, Peter H. Seeberger, and Bartholomäus Pieber. “Photochemical Strategies for Carbon–Heteroatom Bond Formation.” European Journal of Organic Chemistry. Wiley, 2020. https://doi.org/10.1002/ejoc.201901173."},"extern":"1","doi":"10.1002/ejoc.201901173","abstract":[{"text":"Photochemistry enables new synthetic means to form carbon–heteroatom bonds. Photocatalysts can catalyze carbon–heteroatom cross-couplings by electron or energy transfer either alone or in combination with a second catalyst. Photocatalyst-free methods are possible using photolabile substrates or by generating photoactive electron donor-acceptor complexes. This review summarizes and discusses the strategies used in light-mediated carbon–heteroatom bond formations based on the proposed mechanisms.","lang":"eng"}],"page":"1379-1392","issue":"10"},{"author":[{"last_name":"Malik","full_name":"Malik, Jamal A.","first_name":"Jamal A."},{"first_name":"Amiera","full_name":"Madani, Amiera","last_name":"Madani"},{"orcid":"0000-0001-8689-388X","full_name":"Pieber, Bartholomäus","first_name":"Bartholomäus","id":"93e5e5b2-0da6-11ed-8a41-af589a024726","last_name":"Pieber"},{"last_name":"Seeberger","full_name":"Seeberger, Peter H.","first_name":"Peter H."}],"quality_controlled":"1","article_processing_charge":"No","intvolume":" 142","publication_status":"published","external_id":{"pmid":["32469219"]},"month":"06","language":[{"iso":"eng"}],"status":"public","_id":"11978","oa_version":"Published Version","article_type":"original","date_updated":"2023-02-21T10:10:06Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","scopus_import":"1","year":"2020","oa":1,"publication_identifier":{"eissn":["1520-5126"],"issn":["0002-7863"]},"volume":142,"type":"journal_article","date_created":"2022-08-25T10:57:38Z","date_published":"2020-06-24T00:00:00Z","page":"11042-11049","pmid":1,"abstract":[{"lang":"eng","text":"Dual photocatalysis and nickel catalysis can effect cross-coupling under mild conditions, but little is known about the in situ kinetics of this class of reactions. We report a comprehensive kinetic examination of a model carboxylate O-arylation, comparing a state-of-the-art homogeneous photocatalyst (Ir(ppy)3) with a competitive heterogeneous photocatalyst (graphitic carbon nitride). Experimental conditions were adjusted such that the nickel catalytic cycle is saturated with excited photocatalyst. This approach was designed to remove the role of the photocatalyst, by which only the intrinsic behaviors of the nickel catalytic cycles are observed. The two reactions did not display identical kinetics. Ir(ppy)3 deactivates the nickel catalytic cycle and creates more dehalogenated side product. Kinetic data for the reaction using Ir(ppy)3 supports a turnover-limiting reductive elimination. Graphitic carbon nitride gave higher selectivity, even at high photocatalyst-to-nickel ratios. The heterogeneous reaction also showed a rate dependence on aryl halide, indicating that oxidative addition plays a role in rate determination. The results argue against the current mechanistic hypothesis, which states that the photocatalyst is only involved to trigger reductive elimination."}],"issue":"25","citation":{"mla":"Malik, Jamal A., et al. “Evidence for Photocatalyst Involvement in Oxidative Additions of Nickel-Catalyzed Carboxylate O-Arylations.” Journal of the American Chemical Society, vol. 142, no. 25, American Chemical Society, 2020, pp. 11042–49, doi:10.1021/jacs.0c02848.","short":"J.A. Malik, A. Madani, B. Pieber, P.H. Seeberger, Journal of the American Chemical Society 142 (2020) 11042–11049.","apa":"Malik, J. A., Madani, A., Pieber, B., & Seeberger, P. H. (2020). Evidence for photocatalyst involvement in oxidative additions of nickel-catalyzed carboxylate O-arylations. Journal of the American Chemical Society. American Chemical Society. https://doi.org/10.1021/jacs.0c02848","chicago":"Malik, Jamal A., Amiera Madani, Bartholomäus Pieber, and Peter H. Seeberger. “Evidence for Photocatalyst Involvement in Oxidative Additions of Nickel-Catalyzed Carboxylate O-Arylations.” Journal of the American Chemical Society. American Chemical Society, 2020. https://doi.org/10.1021/jacs.0c02848.","ieee":"J. A. Malik, A. Madani, B. Pieber, and P. H. Seeberger, “Evidence for photocatalyst involvement in oxidative additions of nickel-catalyzed carboxylate O-arylations,” Journal of the American Chemical Society, vol. 142, no. 25. American Chemical Society, pp. 11042–11049, 2020.","ama":"Malik JA, Madani A, Pieber B, Seeberger PH. Evidence for photocatalyst involvement in oxidative additions of nickel-catalyzed carboxylate O-arylations. Journal of the American Chemical Society. 2020;142(25):11042-11049. doi:10.1021/jacs.0c02848","ista":"Malik JA, Madani A, Pieber B, Seeberger PH. 2020. Evidence for photocatalyst involvement in oxidative additions of nickel-catalyzed carboxylate O-arylations. Journal of the American Chemical Society. 142(25), 11042–11049."},"title":"Evidence for photocatalyst involvement in oxidative additions of nickel-catalyzed carboxylate O-arylations","day":"24","publication":"Journal of the American Chemical Society","publisher":"American Chemical Society","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1021/jacs.0c02848"}],"extern":"1","doi":"10.1021/jacs.0c02848"},{"article_type":"original","_id":"11979","oa_version":"Preprint","status":"public","language":[{"iso":"eng"}],"intvolume":" 3","month":"08","publication_status":"published","article_processing_charge":"No","quality_controlled":"1","author":[{"first_name":"Sebastian","full_name":"Gisbertz, Sebastian","last_name":"Gisbertz"},{"full_name":"Reischauer, Susanne","first_name":"Susanne","last_name":"Reischauer"},{"full_name":"Pieber, Bartholomäus","orcid":"0000-0001-8689-388X","first_name":"Bartholomäus","id":"93e5e5b2-0da6-11ed-8a41-af589a024726","last_name":"Pieber"}],"date_published":"2020-08-01T00:00:00Z","date_created":"2022-08-25T11:06:16Z","type":"journal_article","volume":3,"publication_identifier":{"eissn":["2520-1158"]},"oa":1,"year":"2020","scopus_import":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2023-02-21T10:10:09Z","issue":"8","abstract":[{"text":"Dual photoredox/nickel-catalysed C–N cross-couplings suffer from low yields for electron-rich aryl halides. The formation of catalytically inactive nickel-black is responsible for this limitation and causes severe reproducibility issues. Here, we demonstrate that catalyst deactivation can be avoided by using a carbon nitride photocatalyst. The broad absorption of the heterogeneous photocatalyst enables wavelength-dependent control of the rate of reductive elimination to prevent nickel-black formation during the coupling of cyclic, secondary amines and aryl halides. A second approach, which is applicable to a broader set of electron-rich aryl halides, is to run the reactions at high concentrations to increase the rate of oxidative addition. Less nucleophilic, primary amines can be coupled with electron-rich aryl halides by stabilizing low-valent nickel intermediates with a suitable additive. The developed protocols enable reproducible, selective C–N cross-couplings of electron-rich aryl bromides and can also be applied for electron-poor aryl chlorides.","lang":"eng"}],"page":"611-620","doi":"10.1038/s41929-020-0473-6","extern":"1","main_file_link":[{"open_access":"1","url":"https://doi.org/10.26434/chemrxiv.10298735"}],"publication":"Nature Catalysis","publisher":"Springer Nature","day":"01","title":"Overcoming limitations in dual photoredox/nickel-catalysed C–N cross-couplings due to catalyst deactivation","citation":{"mla":"Gisbertz, Sebastian, et al. “Overcoming Limitations in Dual Photoredox/Nickel-Catalysed C–N Cross-Couplings Due to Catalyst Deactivation.” Nature Catalysis, vol. 3, no. 8, Springer Nature, 2020, pp. 611–20, doi:10.1038/s41929-020-0473-6.","short":"S. Gisbertz, S. Reischauer, B. Pieber, Nature Catalysis 3 (2020) 611–620.","apa":"Gisbertz, S., Reischauer, S., & Pieber, B. (2020). Overcoming limitations in dual photoredox/nickel-catalysed C–N cross-couplings due to catalyst deactivation. Nature Catalysis. Springer Nature. https://doi.org/10.1038/s41929-020-0473-6","chicago":"Gisbertz, Sebastian, Susanne Reischauer, and Bartholomäus Pieber. “Overcoming Limitations in Dual Photoredox/Nickel-Catalysed C–N Cross-Couplings Due to Catalyst Deactivation.” Nature Catalysis. Springer Nature, 2020. https://doi.org/10.1038/s41929-020-0473-6.","ieee":"S. Gisbertz, S. Reischauer, and B. Pieber, “Overcoming limitations in dual photoredox/nickel-catalysed C–N cross-couplings due to catalyst deactivation,” Nature Catalysis, vol. 3, no. 8. Springer Nature, pp. 611–620, 2020.","ama":"Gisbertz S, Reischauer S, Pieber B. Overcoming limitations in dual photoredox/nickel-catalysed C–N cross-couplings due to catalyst deactivation. Nature Catalysis. 2020;3(8):611-620. doi:10.1038/s41929-020-0473-6","ista":"Gisbertz S, Reischauer S, Pieber B. 2020. Overcoming limitations in dual photoredox/nickel-catalysed C–N cross-couplings due to catalyst deactivation. Nature Catalysis. 3(8), 611–620."}},{"day":"13","publisher":"Springer Nature","publication":"Nature Communications","main_file_link":[{"url":"https://doi.org/10.1038/s41467-020-15131-0","open_access":"1"}],"citation":{"ista":"Mazzanti S, Kurpil B, Pieber B, Antonietti M, Savateev A. 2020. Dichloromethylation of enones by carbon nitride photocatalysis. Nature Communications. 11, 1387.","ieee":"S. Mazzanti, B. Kurpil, B. Pieber, M. Antonietti, and A. Savateev, “Dichloromethylation of enones by carbon nitride photocatalysis,” Nature Communications, vol. 11. Springer Nature, 2020.","ama":"Mazzanti S, Kurpil B, Pieber B, Antonietti M, Savateev A. Dichloromethylation of enones by carbon nitride photocatalysis. Nature Communications. 2020;11. doi:10.1038/s41467-020-15131-0","chicago":"Mazzanti, Stefano, Bogdan Kurpil, Bartholomäus Pieber, Markus Antonietti, and Aleksandr Savateev. “Dichloromethylation of Enones by Carbon Nitride Photocatalysis.” Nature Communications. Springer Nature, 2020. https://doi.org/10.1038/s41467-020-15131-0.","apa":"Mazzanti, S., Kurpil, B., Pieber, B., Antonietti, M., & Savateev, A. (2020). Dichloromethylation of enones by carbon nitride photocatalysis. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-020-15131-0","mla":"Mazzanti, Stefano, et al. “Dichloromethylation of Enones by Carbon Nitride Photocatalysis.” Nature Communications, vol. 11, 1387, Springer Nature, 2020, doi:10.1038/s41467-020-15131-0.","short":"S. Mazzanti, B. Kurpil, B. Pieber, M. Antonietti, A. Savateev, Nature Communications 11 (2020)."},"title":"Dichloromethylation of enones by carbon nitride photocatalysis","extern":"1","doi":"10.1038/s41467-020-15131-0","abstract":[{"text":"Small organic radicals are ubiquitous intermediates in photocatalysis and are used in organic synthesis to install functional groups and to tune electronic properties and pharmacokinetic parameters of the final molecule. Development of new methods to generate small organic radicals with added functionality can further extend the utility of photocatalysis for synthetic needs. Herein, we present a method to generate dichloromethyl radicals from chloroform using a heterogeneous potassium poly(heptazine imide) (K-PHI) photocatalyst under visible light irradiation for C1-extension of the enone backbone. The method is applied on 15 enones, with γ,γ-dichloroketones yields of 18–89%. Due to negative zeta-potential (−40 mV) and small particle size (100 nm) K-PHI suspension is used in quasi-homogeneous flow-photoreactor increasing the productivity by 19 times compared to the batch approach. The resulting γ,γ-dichloroketones, are used as bifunctional building blocks to access value-added organic compounds such as substituted furans and pyrroles.","lang":"eng"}],"article_number":"1387","oa":1,"date_updated":"2023-02-21T10:10:14Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","scopus_import":"1","year":"2020","date_published":"2020-03-13T00:00:00Z","publication_identifier":{"eissn":["2041-1723"]},"volume":11,"type":"journal_article","date_created":"2022-08-25T11:10:15Z","article_processing_charge":"No","author":[{"first_name":"Stefano","full_name":"Mazzanti, Stefano","last_name":"Mazzanti"},{"last_name":"Kurpil","full_name":"Kurpil, Bogdan","first_name":"Bogdan"},{"id":"93e5e5b2-0da6-11ed-8a41-af589a024726","last_name":"Pieber","orcid":"0000-0001-8689-388X","full_name":"Pieber, Bartholomäus","first_name":"Bartholomäus"},{"last_name":"Antonietti","full_name":"Antonietti, Markus","first_name":"Markus"},{"last_name":"Savateev","full_name":"Savateev, Aleksandr","first_name":"Aleksandr"}],"quality_controlled":"1","article_type":"original","month":"03","publication_status":"published","intvolume":" 11","language":[{"iso":"eng"}],"status":"public","_id":"11980","oa_version":"Published Version"},{"date_published":"2020-03-01T00:00:00Z","date_created":"2022-08-25T11:45:02Z","type":"journal_article","volume":5,"publication_identifier":{"eissn":["2058-9883"]},"oa":1,"year":"2020","scopus_import":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2023-02-21T10:10:28Z","article_type":"original","_id":"11986","oa_version":"Published Version","status":"public","language":[{"iso":"eng"}],"publication_status":"published","month":"03","intvolume":" 5","article_processing_charge":"No","quality_controlled":"1","author":[{"last_name":"Rosso","first_name":"Cristian","full_name":"Rosso, Cristian"},{"full_name":"Gisbertz, Sebastian","first_name":"Sebastian","last_name":"Gisbertz"},{"full_name":"Williams, Jason D.","first_name":"Jason D.","last_name":"Williams"},{"full_name":"Gemoets, Hannes P. L.","first_name":"Hannes P. L.","last_name":"Gemoets"},{"last_name":"Debrouwer","first_name":"Wouter","full_name":"Debrouwer, Wouter"},{"id":"93e5e5b2-0da6-11ed-8a41-af589a024726","last_name":"Pieber","orcid":"0000-0001-8689-388X","full_name":"Pieber, Bartholomäus","first_name":"Bartholomäus"},{"last_name":"Kappe","full_name":"Kappe, C. Oliver","first_name":"C. Oliver"}],"doi":"10.1039/d0re00036a","extern":"1","main_file_link":[{"url":"https://doi.org/10.1039/D0RE00036A","open_access":"1"}],"publication":"Reaction Chemistry and Engineering","publisher":"Royal Society of Chemistry","day":"01","title":"An oscillatory plug flow photoreactor facilitates semi-heterogeneous dual nickel/carbon nitride photocatalytic C–N couplings","citation":{"chicago":"Rosso, Cristian, Sebastian Gisbertz, Jason D. Williams, Hannes P. L. Gemoets, Wouter Debrouwer, Bartholomäus Pieber, and C. Oliver Kappe. “An Oscillatory Plug Flow Photoreactor Facilitates Semi-Heterogeneous Dual Nickel/Carbon Nitride Photocatalytic C–N Couplings.” Reaction Chemistry and Engineering. Royal Society of Chemistry, 2020. https://doi.org/10.1039/d0re00036a.","mla":"Rosso, Cristian, et al. “An Oscillatory Plug Flow Photoreactor Facilitates Semi-Heterogeneous Dual Nickel/Carbon Nitride Photocatalytic C–N Couplings.” Reaction Chemistry and Engineering, vol. 5, no. 3, Royal Society of Chemistry, 2020, pp. 597–604, doi:10.1039/d0re00036a.","short":"C. Rosso, S. Gisbertz, J.D. Williams, H.P.L. Gemoets, W. Debrouwer, B. Pieber, C.O. Kappe, Reaction Chemistry and Engineering 5 (2020) 597–604.","apa":"Rosso, C., Gisbertz, S., Williams, J. D., Gemoets, H. P. L., Debrouwer, W., Pieber, B., & Kappe, C. O. (2020). An oscillatory plug flow photoreactor facilitates semi-heterogeneous dual nickel/carbon nitride photocatalytic C–N couplings. Reaction Chemistry and Engineering. Royal Society of Chemistry. https://doi.org/10.1039/d0re00036a","ista":"Rosso C, Gisbertz S, Williams JD, Gemoets HPL, Debrouwer W, Pieber B, Kappe CO. 2020. An oscillatory plug flow photoreactor facilitates semi-heterogeneous dual nickel/carbon nitride photocatalytic C–N couplings. Reaction Chemistry and Engineering. 5(3), 597–604.","ieee":"C. Rosso et al., “An oscillatory plug flow photoreactor facilitates semi-heterogeneous dual nickel/carbon nitride photocatalytic C–N couplings,” Reaction Chemistry and Engineering, vol. 5, no. 3. Royal Society of Chemistry, pp. 597–604, 2020.","ama":"Rosso C, Gisbertz S, Williams JD, et al. An oscillatory plug flow photoreactor facilitates semi-heterogeneous dual nickel/carbon nitride photocatalytic C–N couplings. Reaction Chemistry and Engineering. 2020;5(3):597-604. doi:10.1039/d0re00036a"},"issue":"3","abstract":[{"text":"Carbon nitride materials have emerged as an efficient and sustainable class of heterogeneous photocatalysts, particularly when paired with nickel in dual catalytic cross-coupling reactions. Performing these transformations on larger scales using a continuous process is difficult due to the problems associated with handling solids in flow. By combining an oscillatory pump with a microstructured plug flow photoreactor, a stable suspension of the photocatalyst can be maintained, circumventing clogging of the reactor channels. Through careful tuning of the oscillator properties, the residence time distribution (RTD) was optimized, whilst maintaining a stable catalyst suspension. Short residence times (20 min) were achieved using optimized conditions and the recyclability of the photocatalyst was demonstrated over 10 cycles with no loss of activity. During a stable 4.5 hour scale-out demonstration, the model substrate could be isolated on 12 g scale (90% yield, 2.67 g h−1). Moreover, the method was applied for the gram scale synthesis of an intermediate of the active pharmaceutical ingredient tetracaine.","lang":"eng"}],"page":"597-604"},{"keyword":["Multidisciplinary"],"doi":"10.1073/pnas.1920621117","extern":"1","main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368280/","open_access":"1"}],"department":[{"_id":"XiFe"}],"publication":"Proceedings of the National Academy of Sciences","publisher":"Proceedings of the National Academy of Sciences","day":"22","title":"The Arabidopsis epigenetic regulator ICU11 as an accessory protein of polycomb repressive complex 2","citation":{"short":"R.H. Bloomer, C.E. Hutchison, I. Bäurle, J. Walker, X. Fang, P. Perera, C.N. Velanis, S. Gümüs, C. Spanos, J. Rappsilber, X. Feng, J. Goodrich, C. Dean, Proceedings of the National Academy of Sciences 117 (2020) 16660–16666.","mla":"Bloomer, Rebecca H., et al. “The  Arabidopsis Epigenetic Regulator ICU11 as an Accessory Protein of Polycomb Repressive Complex 2.” Proceedings of the National Academy of Sciences, vol. 117, no. 28, Proceedings of the National Academy of Sciences, 2020, pp. 16660–66, doi:10.1073/pnas.1920621117.","apa":"Bloomer, R. H., Hutchison, C. E., Bäurle, I., Walker, J., Fang, X., Perera, P., … Dean, C. (2020). The  Arabidopsis epigenetic regulator ICU11 as an accessory protein of polycomb repressive complex 2. Proceedings of the National Academy of Sciences. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1920621117","chicago":"Bloomer, Rebecca H., Claire E. Hutchison, Isabel Bäurle, James Walker, Xiaofeng Fang, Pumi Perera, Christos N. Velanis, et al. “The  Arabidopsis Epigenetic Regulator ICU11 as an Accessory Protein of Polycomb Repressive Complex 2.” Proceedings of the National Academy of Sciences. Proceedings of the National Academy of Sciences, 2020. https://doi.org/10.1073/pnas.1920621117.","ama":"Bloomer RH, Hutchison CE, Bäurle I, et al. The  Arabidopsis epigenetic regulator ICU11 as an accessory protein of polycomb repressive complex 2. Proceedings of the National Academy of Sciences. 2020;117(28):16660-16666. doi:10.1073/pnas.1920621117","ieee":"R. H. Bloomer et al., “The  Arabidopsis epigenetic regulator ICU11 as an accessory protein of polycomb repressive complex 2,” Proceedings of the National Academy of Sciences, vol. 117, no. 28. Proceedings of the National Academy of Sciences, pp. 16660–16666, 2020.","ista":"Bloomer RH, Hutchison CE, Bäurle I, Walker J, Fang X, Perera P, Velanis CN, Gümüs S, Spanos C, Rappsilber J, Feng X, Goodrich J, Dean C. 2020. The  Arabidopsis epigenetic regulator ICU11 as an accessory protein of polycomb repressive complex 2. Proceedings of the National Academy of Sciences. 117(28), 16660–16666."},"issue":"28","ddc":["580"],"abstract":[{"lang":"eng","text":"Molecular mechanisms enabling the switching and maintenance of epigenetic states are not fully understood. Distinct histone modifications are often associated with ON/OFF epigenetic states, but how these states are stably maintained through DNA replication, yet in certain situations switch from one to another remains unclear. Here, we address this problem through identification of Arabidopsis INCURVATA11 (ICU11) as a Polycomb Repressive Complex 2 accessory protein. ICU11 robustly immunoprecipitated in vivo with PRC2 core components and the accessory proteins, EMBRYONIC FLOWER 1 (EMF1), LIKE HETEROCHROMATIN PROTEIN1 (LHP1), and TELOMERE_REPEAT_BINDING FACTORS (TRBs). ICU11 encodes a 2-oxoglutarate-dependent dioxygenase, an activity associated with histone demethylation in other organisms, and mutant plants show defects in multiple aspects of the Arabidopsis epigenome. To investigate its primary molecular function we identified the Arabidopsis FLOWERING LOCUS C (FLC) as a direct target and found icu11 disrupted the cold-induced, Polycomb-mediated silencing underlying vernalization. icu11 prevented reduction in H3K36me3 levels normally seen during the early cold phase, supporting a role for ICU11 in H3K36me3 demethylation. This was coincident with an attenuation of H3K27me3 at the internal nucleation site in FLC, and reduction in H3K27me3 levels across the body of the gene after plants were returned to the warm. Thus, ICU11 is required for the cold-induced epigenetic switching between the mutually exclusive chromatin states at FLC, from the active H3K36me3 state to the silenced H3K27me3 state. These data support the importance of physical coupling of histone modification activities to promote epigenetic switching between opposing chromatin states."}],"file":[{"file_size":1105414,"file_id":"12526","date_updated":"2023-02-07T11:29:55Z","checksum":"cedee184cb12f454f2fba4158ff47db9","relation":"main_file","access_level":"open_access","content_type":"application/pdf","creator":"alisjak","date_created":"2023-02-07T11:29:55Z","success":1,"file_name":"2020_PNAS_Bloomer.pdf"}],"pmid":1,"page":"16660-16666","date_published":"2020-05-22T00:00:00Z","has_accepted_license":"1","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"date_created":"2023-01-16T09:15:44Z","type":"journal_article","volume":117,"publication_identifier":{"issn":["0027-8424","1091-6490"]},"oa":1,"year":"2020","scopus_import":"1","date_updated":"2023-05-08T10:53:55Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_type":"original","_id":"12188","oa_version":"Published Version","status":"public","file_date_updated":"2023-02-07T11:29:55Z","language":[{"iso":"eng"}],"publication_status":"published","month":"05","intvolume":" 117","external_id":{"pmid":["32601198"]},"acknowledgement":"We would like to thank Scott Berry for help with ICU-GFP nuclear localization microscopy, Hao Yu and Lisha Shen for assistance with 6mA DNA methylation analysis, Donna Gibson for graphic design assistance, and members of the C.D. and Howard laboratories for helpful discussions. This work was funded by the European Research Council grants to “MEXTIM” (to C.D.) and “SexMeth” (to X. Feng), by the Biotechnological and Biological Sciences Research Council (BBSRC) Institute Strategic Programmes GRO (BB/J004588/1), GEN (BB/P013511/1), BBSRC grant (to X. Feng) (BB/S009620/1), and the Marie Sklodowska–Curie Postdoctoral Fellowships “UNRAVEL” (to R.H.B.) and \"WISDOM\" (to X. Fang). Additional funding via the Wellcome Trust through a Senior Research Fellowship (to J.R.) (103139) and a multiuser equipment grant (108504). The Wellcome Centre for Cell Biology is supported by core funding from the Wellcome Trust (203149).","article_processing_charge":"No","quality_controlled":"1","author":[{"first_name":"Rebecca H.","full_name":"Bloomer, Rebecca H.","last_name":"Bloomer"},{"full_name":"Hutchison, Claire E.","first_name":"Claire E.","last_name":"Hutchison"},{"full_name":"Bäurle, Isabel","first_name":"Isabel","last_name":"Bäurle"},{"last_name":"Walker","full_name":"Walker, James","first_name":"James"},{"full_name":"Fang, Xiaofeng","first_name":"Xiaofeng","last_name":"Fang"},{"last_name":"Perera","first_name":"Pumi","full_name":"Perera, Pumi"},{"last_name":"Velanis","full_name":"Velanis, Christos N.","first_name":"Christos N."},{"last_name":"Gümüs","full_name":"Gümüs, Serin","first_name":"Serin"},{"first_name":"Christos","full_name":"Spanos, Christos","last_name":"Spanos"},{"full_name":"Rappsilber, Juri","first_name":"Juri","last_name":"Rappsilber"},{"id":"e0164712-22ee-11ed-b12a-d80fcdf35958","last_name":"Feng","full_name":"Feng, Xiaoqi","orcid":"0000-0002-4008-1234","first_name":"Xiaoqi"},{"first_name":"Justin","full_name":"Goodrich, Justin","last_name":"Goodrich"},{"last_name":"Dean","full_name":"Dean, Caroline","first_name":"Caroline"}]},{"article_number":"e1008894","issue":"6","pmid":1,"abstract":[{"text":"Meiotic crossovers (COs) are important for reshuffling genetic information between homologous chromosomes and they are essential for their correct segregation. COs are unevenly distributed along chromosomes and the underlying mechanisms controlling CO localization are not well understood. We previously showed that meiotic COs are mis-localized in the absence of AXR1, an enzyme involved in the neddylation/rubylation protein modification pathway in Arabidopsis thaliana. Here, we report that in axr1-/-, male meiocytes show a strong defect in chromosome pairing whereas the formation of the telomere bouquet is not affected. COs are also redistributed towards subtelomeric chromosomal ends where they frequently form clusters, in contrast to large central regions depleted in recombination. The CO suppressed regions correlate with DNA hypermethylation of transposable elements (TEs) in the CHH context in axr1-/- meiocytes. Through examining somatic methylomes, we found axr1-/- affects DNA methylation in a plant, causing hypermethylation in all sequence contexts (CG, CHG and CHH) in TEs. Impairment of the main pathways involved in DNA methylation is epistatic over axr1-/- for DNA methylation in somatic cells but does not restore regular chromosome segregation during meiosis. Collectively, our findings reveal that the neddylation pathway not only regulates hormonal perception and CO distribution but is also, directly or indirectly, a major limiting pathway of TE DNA methylation in somatic cells.","lang":"eng"}],"extern":"1","doi":"10.1371/journal.pgen.1008894","keyword":["Cancer Research","Genetics (clinical)","Genetics","Molecular Biology","Ecology","Evolution","Behavior and Systematics"],"citation":{"ista":"Christophorou N, She W, Long J, Hurel A, Beaubiat S, Idir Y, Tagliaro-Jahns M, Chambon A, Solier V, Vezon D, Grelon M, Feng X, Bouché N, Mézard C. 2020. AXR1 affects DNA methylation independently of its role in regulating meiotic crossover localization. PLOS Genetics. 16(6), e1008894.","ieee":"N. Christophorou et al., “AXR1 affects DNA methylation independently of its role in regulating meiotic crossover localization,” PLOS Genetics, vol. 16, no. 6. Public Library of Science (PLoS), 2020.","ama":"Christophorou N, She W, Long J, et al. AXR1 affects DNA methylation independently of its role in regulating meiotic crossover localization. PLOS Genetics. 2020;16(6). doi:10.1371/journal.pgen.1008894","chicago":"Christophorou, Nicolas, Wenjing She, Jincheng Long, Aurélie Hurel, Sébastien Beaubiat, Yassir Idir, Marina Tagliaro-Jahns, et al. “AXR1 Affects DNA Methylation Independently of Its Role in Regulating Meiotic Crossover Localization.” PLOS Genetics. Public Library of Science (PLoS), 2020. https://doi.org/10.1371/journal.pgen.1008894.","apa":"Christophorou, N., She, W., Long, J., Hurel, A., Beaubiat, S., Idir, Y., … Mézard, C. (2020). AXR1 affects DNA methylation independently of its role in regulating meiotic crossover localization. PLOS Genetics. Public Library of Science (PLoS). https://doi.org/10.1371/journal.pgen.1008894","mla":"Christophorou, Nicolas, et al. “AXR1 Affects DNA Methylation Independently of Its Role in Regulating Meiotic Crossover Localization.” PLOS Genetics, vol. 16, no. 6, e1008894, Public Library of Science (PLoS), 2020, doi:10.1371/journal.pgen.1008894.","short":"N. Christophorou, W. She, J. Long, A. Hurel, S. Beaubiat, Y. Idir, M. Tagliaro-Jahns, A. Chambon, V. Solier, D. Vezon, M. Grelon, X. Feng, N. Bouché, C. Mézard, PLOS Genetics 16 (2020)."},"title":"AXR1 affects DNA methylation independently of its role in regulating meiotic crossover localization","day":"29","publisher":"Public Library of Science (PLoS)","publication":"PLOS Genetics","department":[{"_id":"XiFe"}],"main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351236/"}],"external_id":{"pmid":["32598340"]},"month":"06","publication_status":"published","intvolume":" 16","language":[{"iso":"eng"}],"status":"public","oa_version":"Published Version","_id":"12189","article_type":"original","author":[{"last_name":"Christophorou","full_name":"Christophorou, Nicolas","first_name":"Nicolas"},{"first_name":"Wenjing","full_name":"She, Wenjing","last_name":"She"},{"last_name":"Long","first_name":"Jincheng","full_name":"Long, Jincheng"},{"last_name":"Hurel","full_name":"Hurel, Aurélie","first_name":"Aurélie"},{"first_name":"Sébastien","full_name":"Beaubiat, Sébastien","last_name":"Beaubiat"},{"last_name":"Idir","first_name":"Yassir","full_name":"Idir, Yassir"},{"first_name":"Marina","full_name":"Tagliaro-Jahns, Marina","last_name":"Tagliaro-Jahns"},{"last_name":"Chambon","first_name":"Aurélie","full_name":"Chambon, Aurélie"},{"last_name":"Solier","full_name":"Solier, Victor","first_name":"Victor"},{"first_name":"Daniel","full_name":"Vezon, Daniel","last_name":"Vezon"},{"last_name":"Grelon","full_name":"Grelon, Mathilde","first_name":"Mathilde"},{"full_name":"Feng, Xiaoqi","orcid":"0000-0002-4008-1234","first_name":"Xiaoqi","id":"e0164712-22ee-11ed-b12a-d80fcdf35958","last_name":"Feng"},{"full_name":"Bouché, Nicolas","first_name":"Nicolas","last_name":"Bouché"},{"full_name":"Mézard, Christine","first_name":"Christine","last_name":"Mézard"}],"quality_controlled":"1","article_processing_charge":"No","acknowledgement":"The authors wish to thank Cécile Raynaud, Eric Jenczewski, Rajeev Kumar, Raphaël Mercier and Jean Molinier for critical reading of the manuscript.","publication_identifier":{"issn":["1553-7404"]},"volume":16,"type":"journal_article","date_created":"2023-01-16T09:16:10Z","date_published":"2020-06-29T00:00:00Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2023-05-08T10:54:39Z","scopus_import":"1","year":"2020","oa":1},{"year":"2020","scopus_import":"1","date_updated":"2023-05-10T11:14:56Z","arxiv":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"date_created":"2023-01-16T11:45:07Z","type":"journal_article","volume":209,"publication_identifier":{"issn":["0022-314X"]},"date_published":"2020-04-01T00:00:00Z","quality_controlled":"1","author":[{"id":"7aa8f170-131e-11ed-88e1-a9efd01027cb","last_name":"Verzobio","orcid":"0000-0002-0854-0306","full_name":"Verzobio, Matteo","first_name":"Matteo"}],"article_processing_charge":"No","oa_version":"Preprint","_id":"12310","status":"public","language":[{"iso":"eng"}],"intvolume":" 209","publication_status":"published","month":"04","external_id":{"arxiv":["1906.00632"]},"article_type":"original","title":"Primitive divisors of sequences associated to elliptic curves","citation":{"chicago":"Verzobio, Matteo. “Primitive Divisors of Sequences Associated to Elliptic Curves.” Journal of Number Theory. Elsevier, 2020. https://doi.org/10.1016/j.jnt.2019.09.003.","short":"M. Verzobio, Journal of Number Theory 209 (2020) 378–390.","mla":"Verzobio, Matteo. “Primitive Divisors of Sequences Associated to Elliptic Curves.” Journal of Number Theory, vol. 209, no. 4, Elsevier, 2020, pp. 378–90, doi:10.1016/j.jnt.2019.09.003.","apa":"Verzobio, M. (2020). Primitive divisors of sequences associated to elliptic curves. Journal of Number Theory. Elsevier. https://doi.org/10.1016/j.jnt.2019.09.003","ista":"Verzobio M. 2020. Primitive divisors of sequences associated to elliptic curves. Journal of Number Theory. 209(4), 378–390.","ieee":"M. Verzobio, “Primitive divisors of sequences associated to elliptic curves,” Journal of Number Theory, vol. 209, no. 4. Elsevier, pp. 378–390, 2020.","ama":"Verzobio M. Primitive divisors of sequences associated to elliptic curves. Journal of Number Theory. 2020;209(4):378-390. doi:10.1016/j.jnt.2019.09.003"},"main_file_link":[{"url":"https://doi.org/10.48550/arXiv.1906.00632","open_access":"1"}],"publication":"Journal of Number Theory","publisher":"Elsevier","day":"01","keyword":["Algebra and Number Theory"],"doi":"10.1016/j.jnt.2019.09.003","extern":"1","page":"378-390","abstract":[{"text":"Let be a sequence of points on an elliptic curve defined over a number field K. In this paper, we study the denominators of the x-coordinates of this sequence. We prove that, if Q is a torsion point of prime order, then for n large enough there always exists a primitive divisor. Later on, we show the link between the study of the primitive divisors and a Lang-Trotter conjecture. Indeed, given two points P and Q on the elliptic curve, we prove a lower bound for the number of primes p such that P is in the orbit of Q modulo p.","lang":"eng"}],"issue":"4"},{"quality_controlled":"1","author":[{"full_name":"Herreid, Sam","first_name":"Sam","last_name":"Herreid"},{"last_name":"Pellicciotti","id":"b28f055a-81ea-11ed-b70c-a9fe7f7b0e70","first_name":"Francesca","full_name":"Pellicciotti, Francesca"}],"article_processing_charge":"No","status":"public","oa_version":"None","_id":"12593","month":"09","publication_status":"published","intvolume":" 13","language":[{"iso":"eng"}],"article_type":"original","year":"2020","date_updated":"2023-02-28T12:45:37Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","scopus_import":"1","type":"journal_article","date_created":"2023-02-20T08:12:17Z","publication_identifier":{"eissn":["1752-0908"],"issn":["1752-0894"]},"volume":13,"date_published":"2020-09-02T00:00:00Z","page":"621-627","abstract":[{"text":"Rock debris can accumulate on glacier surfaces and dramatically reduce glacier melt. The structure of a debris cover is unique to each glacier and sensitive to climate. Despite this, debris cover has been omitted from global glacier models and forecasts of their response to a changing climate. Fundamental to resolving these omissions is a global map of debris cover and an estimate of its future spatial evolution. Here we use Landsat imagery and a detailed correction to the Randolph Glacier Inventory to show that 7.3% of mountain glacier area is debris covered and over half of Earth’s debris is concentrated in three regions: Alaska (38.6% of total debris-covered area), Southwest Asia (12.6%) and Greenland (12.0%). We use a set of new metrics, which include stage, the current position of a glacier on its trajectory towards reaching its spatial carrying capacity of debris cover, to quantify the state of glaciers. Debris cover is present on 44% of Earth’s glaciers and prominent (>1.0 km2) on 15%. Of Earth’s glaciers, 20% have a substantial percentage of debris cover for which the net stage is 36% and the bulk of individual glaciers have evolved beyond an optimal moraine configuration favourable for debris-cover expansion. Use of this dataset in global-scale models will enable improved estimates of melt over 10.6% of the global glacier domain.","lang":"eng"}],"issue":"9","title":"The state of rock debris covering Earth’s glaciers","related_material":{"link":[{"url":"https://doi.org/10.1038/s41561-020-0630-1","relation":"erratum"}]},"citation":{"ama":"Herreid S, Pellicciotti F. The state of rock debris covering Earth’s glaciers. Nature Geoscience. 2020;13(9):621-627. doi:10.1038/s41561-020-0615-0","ieee":"S. Herreid and F. Pellicciotti, “The state of rock debris covering Earth’s glaciers,” Nature Geoscience, vol. 13, no. 9. Springer Nature, pp. 621–627, 2020.","ista":"Herreid S, Pellicciotti F. 2020. The state of rock debris covering Earth’s glaciers. Nature Geoscience. 13(9), 621–627.","mla":"Herreid, Sam, and Francesca Pellicciotti. “The State of Rock Debris Covering Earth’s Glaciers.” Nature Geoscience, vol. 13, no. 9, Springer Nature, 2020, pp. 621–27, doi:10.1038/s41561-020-0615-0.","short":"S. Herreid, F. Pellicciotti, Nature Geoscience 13 (2020) 621–627.","apa":"Herreid, S., & Pellicciotti, F. (2020). The state of rock debris covering Earth’s glaciers. Nature Geoscience. Springer Nature. https://doi.org/10.1038/s41561-020-0615-0","chicago":"Herreid, Sam, and Francesca Pellicciotti. “The State of Rock Debris Covering Earth’s Glaciers.” Nature Geoscience. Springer Nature, 2020. https://doi.org/10.1038/s41561-020-0615-0."},"publisher":"Springer Nature","publication":"Nature Geoscience","day":"02","keyword":["General Earth and Planetary Sciences"],"extern":"1","doi":"10.1038/s41561-020-0615-0"},{"abstract":[{"lang":"eng","text":"Information about end-of-winter spatial distribution of snow depth is important for seasonal forecasts of spring/summer streamflow in high-mountain regions. Nevertheless, such information typically relies upon extrapolation from a sparse network of observations at low elevations. Here, we test the potential of high-resolution snow depth data derived from optical stereophotogrammetry of Pléiades satellites for improving the representation of snow depth initial conditions (SDICs) in a glacio-hydrological model and assess potential improvements in the skill of snowmelt and streamflow simulations in a high-elevation Andean catchment. We calibrate model parameters controlling glacier mass balance and snow cover evolution using ground-based and satellite observations, and consider the relative importance of accurate estimates of SDICs compared to model parameters and forcings. We find that Pléiades SDICs improve the simulation of snow-covered area, glacier mass balance, and monthly streamflow compared to alternative SDICs based upon extrapolation of meteorological variables or statistical methods to estimate SDICs based upon topography. Model simulations are found to be sensitive to SDICs in the early spring (up to 48% variability in modeled streamflow compared to the best estimate model), and to temperature gradients in all months that control albedo and melt rates over a large elevation range (>2,400 m). As such, appropriately characterizing the distribution of total snow volume with elevation is important for reproducing total streamflow and the proportions of snowmelt. Therefore, optical stereo-photogrammetry offers an advantage for obtaining SDICs that aid both the timing and magnitude of streamflow simulations, process representation (e.g., snow cover evolution) and has the potential for large spatial domains."}],"issue":"8","article_number":"e2020WR027188","day":"01","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1029/2020WR027188"}],"publisher":"American Geophysical Union","publication":"Water Resources Research","citation":{"apa":"Shaw, T. E., Caro, A., Mendoza, P., Ayala, Á., Pellicciotti, F., Gascoin, S., & McPhee, J. (2020). The utility of optical satellite winter snow depths for initializing a glacio‐hydrological model of a High‐Elevation, Andean catchment. Water Resources Research. American Geophysical Union. https://doi.org/10.1029/2020wr027188","short":"T.E. Shaw, A. Caro, P. Mendoza, Á. Ayala, F. Pellicciotti, S. Gascoin, J. McPhee, Water Resources Research 56 (2020).","mla":"Shaw, Thomas E., et al. “The Utility of Optical Satellite Winter Snow Depths for Initializing a Glacio‐hydrological Model of a High‐Elevation, Andean Catchment.” Water Resources Research, vol. 56, no. 8, e2020WR027188, American Geophysical Union, 2020, doi:10.1029/2020wr027188.","chicago":"Shaw, Thomas E., Alexis Caro, Pablo Mendoza, Álvaro Ayala, Francesca Pellicciotti, Simon Gascoin, and James McPhee. “The Utility of Optical Satellite Winter Snow Depths for Initializing a Glacio‐hydrological Model of a High‐Elevation, Andean Catchment.” Water Resources Research. American Geophysical Union, 2020. https://doi.org/10.1029/2020wr027188.","ieee":"T. E. Shaw et al., “The utility of optical satellite winter snow depths for initializing a glacio‐hydrological model of a High‐Elevation, Andean catchment,” Water Resources Research, vol. 56, no. 8. American Geophysical Union, 2020.","ama":"Shaw TE, Caro A, Mendoza P, et al. The utility of optical satellite winter snow depths for initializing a glacio‐hydrological model of a High‐Elevation, Andean catchment. Water Resources Research. 2020;56(8). doi:10.1029/2020wr027188","ista":"Shaw TE, Caro A, Mendoza P, Ayala Á, Pellicciotti F, Gascoin S, McPhee J. 2020. The utility of optical satellite winter snow depths for initializing a glacio‐hydrological model of a High‐Elevation, Andean catchment. Water Resources Research. 56(8), e2020WR027188."},"title":"The utility of optical satellite winter snow depths for initializing a glacio‐hydrological model of a High‐Elevation, Andean catchment","doi":"10.1029/2020wr027188","extern":"1","keyword":["Water Science and Technology"],"article_processing_charge":"No","author":[{"full_name":"Shaw, Thomas E.","first_name":"Thomas E.","last_name":"Shaw"},{"last_name":"Caro","full_name":"Caro, Alexis","first_name":"Alexis"},{"last_name":"Mendoza","first_name":"Pablo","full_name":"Mendoza, Pablo"},{"first_name":"Álvaro","full_name":"Ayala, Álvaro","last_name":"Ayala"},{"last_name":"Pellicciotti","id":"b28f055a-81ea-11ed-b70c-a9fe7f7b0e70","first_name":"Francesca","full_name":"Pellicciotti, Francesca"},{"full_name":"Gascoin, Simon","first_name":"Simon","last_name":"Gascoin"},{"last_name":"McPhee","full_name":"McPhee, James","first_name":"James"}],"quality_controlled":"1","article_type":"original","language":[{"iso":"eng"}],"publication_status":"published","month":"08","intvolume":" 56","_id":"12594","oa_version":"Published Version","status":"public","oa":1,"scopus_import":"1","date_updated":"2023-02-28T12:41:45Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","year":"2020","date_published":"2020-08-01T00:00:00Z","volume":56,"publication_identifier":{"issn":["0043-1397"],"eissn":["1944-7973"]},"date_created":"2023-02-20T08:12:22Z","type":"journal_article"},{"abstract":[{"text":"The seasonal dynamic changes of Tibetan glaciers have seen little prior investigation, despite the increase in geodetic studies of multi-year changes. This study compares seasonal glacier dynamics (“cold” and “warm” seasons) in the ablation zone of Parlung No. 4 Glacier, a temperate glacier in the monsoon-influenced southeastern Tibetan Plateau, by using repeat unpiloted aerial vehicle (UAV) surveys combined with Structure-from-Motion (SfM) photogrammetry and ground stake measurements. Our results showed that the surveyed ablation zone had a mean change of −2.7 m of ice surface elevation during the period of September 2018 to October 2019 but is characterized by significant seasonal cyclic variations with ice surface elevation lifting (+2.0 m) in the cold season (September 2018 to June 2019) but lowering (−4.7 m) in the warm season (June 2019 to October 2019). Over an annual timescale, surface lowering was greatly suppressed by the resupply of ice from the glacier’s accumulation area—the annual emergence velocity compensates for about 55% of surface ablation in our study area. Cold season emergence velocities (3.0 ± 1.2 m) were ~5-times larger than those observed in the warm season (0.6 ± 1.0 m). Distinct spring precipitation patterns may contribute to these distinct seasonal signals. Such seasonal dynamic conditions are possibly critical for different glacier responses to climate change in this region of the Tibetan Plateau, and perhaps further afield.","lang":"eng"}],"issue":"15","article_number":"2389","main_file_link":[{"open_access":"1","url":"https://doi.org/10.3390/rs12152389"}],"publisher":"MDPI","publication":"Remote Sensing","day":"24","title":"Seasonal dynamics of a temperate Tibetan glacier revealed by high-resolution UAV photogrammetry and in situ measurements","citation":{"short":"W. Yang, C. Zhao, M. Westoby, T. Yao, Y. Wang, F. Pellicciotti, J. Zhou, Z. He, E. Miles, Remote Sensing 12 (2020).","mla":"Yang, Wei, et al. “Seasonal Dynamics of a Temperate Tibetan Glacier Revealed by High-Resolution UAV Photogrammetry and in Situ Measurements.” Remote Sensing, vol. 12, no. 15, 2389, MDPI, 2020, doi:10.3390/rs12152389.","apa":"Yang, W., Zhao, C., Westoby, M., Yao, T., Wang, Y., Pellicciotti, F., … Miles, E. (2020). Seasonal dynamics of a temperate Tibetan glacier revealed by high-resolution UAV photogrammetry and in situ measurements. Remote Sensing. MDPI. https://doi.org/10.3390/rs12152389","chicago":"Yang, Wei, Chuanxi Zhao, Matthew Westoby, Tandong Yao, Yongjie Wang, Francesca Pellicciotti, Jianmin Zhou, Zhen He, and Evan Miles. “Seasonal Dynamics of a Temperate Tibetan Glacier Revealed by High-Resolution UAV Photogrammetry and in Situ Measurements.” Remote Sensing. MDPI, 2020. https://doi.org/10.3390/rs12152389.","ama":"Yang W, Zhao C, Westoby M, et al. Seasonal dynamics of a temperate Tibetan glacier revealed by high-resolution UAV photogrammetry and in situ measurements. Remote Sensing. 2020;12(15). doi:10.3390/rs12152389","ieee":"W. Yang et al., “Seasonal dynamics of a temperate Tibetan glacier revealed by high-resolution UAV photogrammetry and in situ measurements,” Remote Sensing, vol. 12, no. 15. MDPI, 2020.","ista":"Yang W, Zhao C, Westoby M, Yao T, Wang Y, Pellicciotti F, Zhou J, He Z, Miles E. 2020. Seasonal dynamics of a temperate Tibetan glacier revealed by high-resolution UAV photogrammetry and in situ measurements. Remote Sensing. 12(15), 2389."},"doi":"10.3390/rs12152389","extern":"1","article_processing_charge":"No","quality_controlled":"1","author":[{"first_name":"Wei","full_name":"Yang, Wei","last_name":"Yang"},{"last_name":"Zhao","first_name":"Chuanxi","full_name":"Zhao, Chuanxi"},{"first_name":"Matthew","full_name":"Westoby, Matthew","last_name":"Westoby"},{"last_name":"Yao","first_name":"Tandong","full_name":"Yao, Tandong"},{"first_name":"Yongjie","full_name":"Wang, Yongjie","last_name":"Wang"},{"first_name":"Francesca","full_name":"Pellicciotti, Francesca","last_name":"Pellicciotti","id":"b28f055a-81ea-11ed-b70c-a9fe7f7b0e70"},{"last_name":"Zhou","full_name":"Zhou, Jianmin","first_name":"Jianmin"},{"first_name":"Zhen","full_name":"He, Zhen","last_name":"He"},{"full_name":"Miles, Evan","first_name":"Evan","last_name":"Miles"}],"article_type":"original","oa_version":"Published Version","_id":"12595","status":"public","language":[{"iso":"eng"}],"intvolume":" 12","publication_status":"published","month":"07","oa":1,"year":"2020","scopus_import":"1","date_updated":"2023-02-28T12:36:22Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_published":"2020-07-24T00:00:00Z","date_created":"2023-02-20T08:12:29Z","type":"journal_article","volume":12,"publication_identifier":{"issn":["2072-4292"]}},{"oa":1,"scopus_import":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2023-02-28T12:32:31Z","year":"2020","date_published":"2020-06-24T00:00:00Z","volume":14,"publication_identifier":{"issn":["1994-0424"]},"date_created":"2023-02-20T08:12:36Z","type":"journal_article","article_processing_charge":"No","author":[{"last_name":"Ayala","first_name":"Álvaro","full_name":"Ayala, Álvaro"},{"last_name":"Farías-Barahona","full_name":"Farías-Barahona, David","first_name":"David"},{"first_name":"Matthias","full_name":"Huss, Matthias","last_name":"Huss"},{"id":"b28f055a-81ea-11ed-b70c-a9fe7f7b0e70","last_name":"Pellicciotti","full_name":"Pellicciotti, Francesca","first_name":"Francesca"},{"full_name":"McPhee, James","first_name":"James","last_name":"McPhee"},{"last_name":"Farinotti","first_name":"Daniel","full_name":"Farinotti, Daniel"}],"quality_controlled":"1","article_type":"original","language":[{"iso":"eng"}],"month":"06","intvolume":" 14","publication_status":"published","oa_version":"Published Version","_id":"12596","status":"public","day":"24","main_file_link":[{"open_access":"1","url":"https://doi.org/10.5194/tc-14-2005-2020"}],"publisher":"Copernicus Publications","publication":"The Cryosphere","citation":{"chicago":"Ayala, Álvaro, David Farías-Barahona, Matthias Huss, Francesca Pellicciotti, James McPhee, and Daniel Farinotti. “Glacier Runoff Variations since 1955 in the Maipo River Basin, in the Semiarid Andes of Central Chile.” The Cryosphere. Copernicus Publications, 2020. https://doi.org/10.5194/tc-14-2005-2020.","apa":"Ayala, Á., Farías-Barahona, D., Huss, M., Pellicciotti, F., McPhee, J., & Farinotti, D. (2020). Glacier runoff variations since 1955 in the Maipo River basin, in the semiarid Andes of central Chile. The Cryosphere. Copernicus Publications. https://doi.org/10.5194/tc-14-2005-2020","mla":"Ayala, Álvaro, et al. “Glacier Runoff Variations since 1955 in the Maipo River Basin, in the Semiarid Andes of Central Chile.” The Cryosphere, vol. 14, no. 6, Copernicus Publications, 2020, pp. 2005–27, doi:10.5194/tc-14-2005-2020.","short":"Á. Ayala, D. Farías-Barahona, M. Huss, F. Pellicciotti, J. McPhee, D. Farinotti, The Cryosphere 14 (2020) 2005–2027.","ista":"Ayala Á, Farías-Barahona D, Huss M, Pellicciotti F, McPhee J, Farinotti D. 2020. Glacier runoff variations since 1955 in the Maipo River basin, in the semiarid Andes of central Chile. The Cryosphere. 14(6), 2005–2027.","ama":"Ayala Á, Farías-Barahona D, Huss M, Pellicciotti F, McPhee J, Farinotti D. Glacier runoff variations since 1955 in the Maipo River basin, in the semiarid Andes of central Chile. The Cryosphere. 2020;14(6):2005-2027. doi:10.5194/tc-14-2005-2020","ieee":"Á. Ayala, D. Farías-Barahona, M. Huss, F. Pellicciotti, J. McPhee, and D. Farinotti, “Glacier runoff variations since 1955 in the Maipo River basin, in the semiarid Andes of central Chile,” The Cryosphere, vol. 14, no. 6. Copernicus Publications, pp. 2005–2027, 2020."},"title":"Glacier runoff variations since 1955 in the Maipo River basin, in the semiarid Andes of central Chile","doi":"10.5194/tc-14-2005-2020","extern":"1","keyword":["Earth-Surface Processes","Water Science and Technology"],"abstract":[{"text":"As glaciers adjust their size in response to climate variations, long-term changes in meltwater production can be expected, affecting the local availability of water resources. We investigate glacier runoff in the period 1955–2016 in the Maipo River basin (4843 km2, 33.0–34.3∘ S, 69.8–70.5∘ W), in the semiarid Andes of Chile. The basin contains more than 800 glaciers, which cover 378 km2 in total (inventoried in 2000). We model the mass balance and runoff contribution of 26 glaciers with the physically oriented and fully distributed TOPKAPI (Topographic Kinematic Approximation and Integration)-ETH glacio-hydrological model and extrapolate the results to the entire basin. TOPKAPI-ETH is run at a daily time step using several glaciological and meteorological datasets, and its results are evaluated against streamflow records, remotely sensed snow cover, and geodetic mass balances for the periods 1955–2000 and 2000–2013. Results show that in 1955–2016 glacier mass balance had a general decreasing trend as a basin average but also had differences between the main sub-catchments. Glacier volume decreased by one-fifth (from 18.6±4.5 to 14.9±2.9 km3). Runoff from the initially glacierized areas was 177±25 mm yr−1 (16±7 % of the total contributions to the basin), but it shows a decreasing sequence of maxima, which can be linked to the interplay between a decrease in precipitation since the 1980s and the reduction of ice melt. Glaciers in the Maipo River basin will continue retreating because they are not in equilibrium with the current climate. In a hypothetical constant climate scenario, glacier volume would reduce to 81±38 % of the year 2000 volume, and glacier runoff would be 78±30 % of the 1955–2016 average. This would considerably decrease the drought mitigation capacity of the basin.","lang":"eng"}],"page":"2005-2027","issue":"6"},{"page":"386-400","abstract":[{"lang":"eng","text":"We examine the spatial patterns of near-surface air temperature (Ta) over a melting glacier using a multi-annual dataset from McCall Glacier, Alaska. The dataset consists of a 10-year (2005–2014) meteorological record along the glacier centreline up to an upper glacier cirque, spanning an elevation difference of 900 m. We test the validity of on-glacier linear lapse rates, and a model that calculates Ta based on the influence of katabatic winds and other heat sources along the glacier flow line. During the coldest hours of each summer (10% of time), average lapse rates across the entire glacier range from −4.7 to −6.7°C km−1, with a strong relationship between Ta and elevation (R2 > 0.7). During warm conditions, Ta shows more complex, non-linear patterns that are better explained by the flow line-dependent model, reducing errors by up to 0.5°C compared with linear lapse rates, although more uncertainty might be associated with these observations due to occasionally poor sensor ventilation. We conclude that Ta spatial distribution can vary significantly from year to year, and from one glacier section to another. Importantly, extrapolations using linear lapse rates from the ablation zone might lead to large underestimations of Ta on the upper glacier areas."}],"issue":"257","citation":{"ista":"Troxler P, Ayala Á, Shaw TE, Nolan M, Brock BW, Pellicciotti F. 2020. Modelling spatial patterns of near-surface air temperature over a decade of melt seasons on McCall Glacier, Alaska. Journal of Glaciology. 66(257), 386–400.","ama":"Troxler P, Ayala Á, Shaw TE, Nolan M, Brock BW, Pellicciotti F. Modelling spatial patterns of near-surface air temperature over a decade of melt seasons on McCall Glacier, Alaska. Journal of Glaciology. 2020;66(257):386-400. doi:10.1017/jog.2020.12","ieee":"P. Troxler, Á. Ayala, T. E. Shaw, M. Nolan, B. W. Brock, and F. Pellicciotti, “Modelling spatial patterns of near-surface air temperature over a decade of melt seasons on McCall Glacier, Alaska,” Journal of Glaciology, vol. 66, no. 257. Cambridge University Press, pp. 386–400, 2020.","chicago":"Troxler, Patrick, Álvaro Ayala, Thomas E. Shaw, Matt Nolan, Ben W. Brock, and Francesca Pellicciotti. “Modelling Spatial Patterns of Near-Surface Air Temperature over a Decade of Melt Seasons on McCall Glacier, Alaska.” Journal of Glaciology. Cambridge University Press, 2020. https://doi.org/10.1017/jog.2020.12.","apa":"Troxler, P., Ayala, Á., Shaw, T. E., Nolan, M., Brock, B. W., & Pellicciotti, F. (2020). Modelling spatial patterns of near-surface air temperature over a decade of melt seasons on McCall Glacier, Alaska. Journal of Glaciology. Cambridge University Press. https://doi.org/10.1017/jog.2020.12","mla":"Troxler, Patrick, et al. “Modelling Spatial Patterns of Near-Surface Air Temperature over a Decade of Melt Seasons on McCall Glacier, Alaska.” Journal of Glaciology, vol. 66, no. 257, Cambridge University Press, 2020, pp. 386–400, doi:10.1017/jog.2020.12.","short":"P. Troxler, Á. Ayala, T.E. Shaw, M. Nolan, B.W. Brock, F. Pellicciotti, Journal of Glaciology 66 (2020) 386–400."},"title":"Modelling spatial patterns of near-surface air temperature over a decade of melt seasons on McCall Glacier, Alaska","day":"01","main_file_link":[{"url":"https://doi.org/10.1017/jog.2020.12","open_access":"1"}],"publication":"Journal of Glaciology","publisher":"Cambridge University Press","doi":"10.1017/jog.2020.12","extern":"1","keyword":["Earth-Surface Processes"],"author":[{"first_name":"Patrick","full_name":"Troxler, Patrick","last_name":"Troxler"},{"last_name":"Ayala","full_name":"Ayala, Álvaro","first_name":"Álvaro"},{"last_name":"Shaw","first_name":"Thomas E.","full_name":"Shaw, Thomas E."},{"first_name":"Matt","full_name":"Nolan, Matt","last_name":"Nolan"},{"last_name":"Brock","first_name":"Ben W.","full_name":"Brock, Ben W."},{"id":"b28f055a-81ea-11ed-b70c-a9fe7f7b0e70","last_name":"Pellicciotti","full_name":"Pellicciotti, Francesca","first_name":"Francesca"}],"quality_controlled":"1","article_processing_charge":"No","language":[{"iso":"eng"}],"publication_status":"published","month":"06","intvolume":" 66","_id":"12597","oa_version":"Published Version","status":"public","article_type":"original","scopus_import":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2023-02-28T12:28:45Z","year":"2020","oa":1,"volume":66,"publication_identifier":{"issn":["0022-1430"],"eissn":["1727-5652"]},"date_created":"2023-02-20T08:12:42Z","type":"journal_article","date_published":"2020-06-01T00:00:00Z"},{"issue":"2","article_number":"e2019WR024880","abstract":[{"text":"Obtaining detailed information about high mountain snowpacks is often limited by insufficient ground-based observations and uncertainty in the (re)distribution of solid precipitation. We utilize high-resolution optical images from Pléiades satellites to generate a snow depth map, at a spatial resolution of 4 m, for a high mountain catchment of central Chile. Results are negatively biased (median difference of −0.22 m) when compared against observations from a terrestrial Light Detection And Ranging scan, though replicate general snow depth variability well. Additionally, the Pléiades dataset is subject to data gaps (17% of total pixels), negative values for shallow snow (12%), and noise on slopes >40–50° (2%). We correct and filter the Pléiades snow depths using surface classification techniques of snow-free areas and a random forest model for data gap filling. Snow depths (with an estimated error of ~0.36 m) average 1.66 m and relate well to topographical parameters such as elevation and northness in a similar way to previous studies. However, estimations of snow depth based upon topography (TOPO) or physically based modeling (DBSM) cannot resolve localized processes (i.e., avalanching or wind scouring) that are detected by Pléiades, even when forced with locally calibrated data. Comparing these alternative model approaches to corrected Pléiades snow depths reveals total snow volume differences between −28% (DBSM) and +54% (TOPO) for the catchment and large differences across most elevation bands. Pléiades represents an important contribution to understanding snow accumulation at sparsely monitored catchments, though ideally requires a careful systematic validation procedure to identify catchment-scale biases and errors in the snow depth derivation.","lang":"eng"}],"keyword":["Water Science and Technology"],"extern":"1","doi":"10.1029/2019wr024880","publication":"Water Resources Research","publisher":"American Geophysical Union","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1029/2019WR024880"}],"day":"01","title":"Snow depth patterns in a high mountain Andean catchment from satellite optical tristereoscopic remote sensing","citation":{"ista":"Shaw TE, Gascoin S, Mendoza PA, Pellicciotti F, McPhee J. 2020. Snow depth patterns in a high mountain Andean catchment from satellite optical tristereoscopic remote sensing. Water Resources Research. 56(2), e2019WR024880.","ieee":"T. E. Shaw, S. Gascoin, P. A. Mendoza, F. Pellicciotti, and J. McPhee, “Snow depth patterns in a high mountain Andean catchment from satellite optical tristereoscopic remote sensing,” Water Resources Research, vol. 56, no. 2. American Geophysical Union, 2020.","ama":"Shaw TE, Gascoin S, Mendoza PA, Pellicciotti F, McPhee J. Snow depth patterns in a high mountain Andean catchment from satellite optical tristereoscopic remote sensing. Water Resources Research. 2020;56(2). doi:10.1029/2019wr024880","chicago":"Shaw, Thomas E., Simon Gascoin, Pablo A. Mendoza, Francesca Pellicciotti, and James McPhee. “Snow Depth Patterns in a High Mountain Andean Catchment from Satellite Optical Tristereoscopic Remote Sensing.” Water Resources Research. American Geophysical Union, 2020. https://doi.org/10.1029/2019wr024880.","apa":"Shaw, T. E., Gascoin, S., Mendoza, P. A., Pellicciotti, F., & McPhee, J. (2020). Snow depth patterns in a high mountain Andean catchment from satellite optical tristereoscopic remote sensing. Water Resources Research. American Geophysical Union. https://doi.org/10.1029/2019wr024880","short":"T.E. Shaw, S. Gascoin, P.A. Mendoza, F. Pellicciotti, J. McPhee, Water Resources Research 56 (2020).","mla":"Shaw, Thomas E., et al. “Snow Depth Patterns in a High Mountain Andean Catchment from Satellite Optical Tristereoscopic Remote Sensing.” Water Resources Research, vol. 56, no. 2, e2019WR024880, American Geophysical Union, 2020, doi:10.1029/2019wr024880."},"article_type":"original","status":"public","oa_version":"Published Version","_id":"12598","publication_status":"published","month":"02","intvolume":" 56","language":[{"iso":"eng"}],"article_processing_charge":"No","quality_controlled":"1","author":[{"full_name":"Shaw, Thomas E.","first_name":"Thomas E.","last_name":"Shaw"},{"last_name":"Gascoin","full_name":"Gascoin, Simon","first_name":"Simon"},{"first_name":"Pablo A.","full_name":"Mendoza, Pablo A.","last_name":"Mendoza"},{"full_name":"Pellicciotti, Francesca","first_name":"Francesca","id":"b28f055a-81ea-11ed-b70c-a9fe7f7b0e70","last_name":"Pellicciotti"},{"first_name":"James","full_name":"McPhee, James","last_name":"McPhee"}],"date_published":"2020-02-01T00:00:00Z","type":"journal_article","date_created":"2023-02-20T08:12:47Z","publication_identifier":{"eissn":["1944-7973"],"issn":["0043-1397"]},"volume":56,"oa":1,"year":"2020","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2023-02-28T12:26:14Z","scopus_import":"1"},{"article_processing_charge":"No","abstract":[{"lang":"eng","text":"Mountains are the water towers of the world, supplying a substantial part of both natural and anthropogenic water demands1,2. They are highly sensitive and prone to climate change3,4, yet their importance and vulnerability have not been quantified at the global scale. Here we present a global water tower index (WTI), which ranks all water towers in terms of their water-supplying role and the downstream dependence of ecosystems and society. For each water tower, we assess its vulnerability related to water stress, governance, hydropolitical tension and future climatic and socio-economic changes. We conclude that the most important (highest WTI) water towers are also among the most vulnerable, and that climatic and socio-economic changes will affect them profoundly. This could negatively impact 1.9 billion people living in (0.3 billion) or directly downstream of (1.6 billion) mountainous areas. Immediate action is required to safeguard the future of the world’s most important and vulnerable water towers."}],"quality_controlled":"1","page":"364-369","author":[{"first_name":"W. W.","full_name":"Immerzeel, W. W.","last_name":"Immerzeel"},{"full_name":"Lutz, A. F.","first_name":"A. F.","last_name":"Lutz"},{"first_name":"M.","full_name":"Andrade, M.","last_name":"Andrade"},{"first_name":"A.","full_name":"Bahl, A.","last_name":"Bahl"},{"last_name":"Biemans","full_name":"Biemans, H.","first_name":"H."},{"last_name":"Bolch","first_name":"T.","full_name":"Bolch, T."},{"full_name":"Hyde, S.","first_name":"S.","last_name":"Hyde"},{"full_name":"Brumby, S.","first_name":"S.","last_name":"Brumby"},{"full_name":"Davies, B. J.","first_name":"B. J.","last_name":"Davies"},{"last_name":"Elmore","first_name":"A. C.","full_name":"Elmore, A. C."},{"full_name":"Emmer, A.","first_name":"A.","last_name":"Emmer"},{"last_name":"Feng","full_name":"Feng, M.","first_name":"M."},{"first_name":"A.","full_name":"Fernández, A.","last_name":"Fernández"},{"last_name":"Haritashya","full_name":"Haritashya, U.","first_name":"U."},{"full_name":"Kargel, J. S.","first_name":"J. S.","last_name":"Kargel"},{"last_name":"Koppes","first_name":"M.","full_name":"Koppes, M."},{"last_name":"Kraaijenbrink","first_name":"P. D. A.","full_name":"Kraaijenbrink, P. D. A."},{"last_name":"Kulkarni","full_name":"Kulkarni, A. V.","first_name":"A. V."},{"last_name":"Mayewski","full_name":"Mayewski, P. A.","first_name":"P. A."},{"last_name":"Nepal","full_name":"Nepal, S.","first_name":"S."},{"last_name":"Pacheco","full_name":"Pacheco, P.","first_name":"P."},{"full_name":"Painter, T. H.","first_name":"T. H.","last_name":"Painter"},{"full_name":"Pellicciotti, Francesca","first_name":"Francesca","id":"b28f055a-81ea-11ed-b70c-a9fe7f7b0e70","last_name":"Pellicciotti"},{"last_name":"Rajaram","full_name":"Rajaram, H.","first_name":"H."},{"first_name":"S.","full_name":"Rupper, S.","last_name":"Rupper"},{"last_name":"Sinisalo","full_name":"Sinisalo, A.","first_name":"A."},{"full_name":"Shrestha, A. B.","first_name":"A. B.","last_name":"Shrestha"},{"first_name":"D.","full_name":"Viviroli, D.","last_name":"Viviroli"},{"last_name":"Wada","full_name":"Wada, Y.","first_name":"Y."},{"last_name":"Xiao","full_name":"Xiao, C.","first_name":"C."},{"full_name":"Yao, T.","first_name":"T.","last_name":"Yao"},{"last_name":"Baillie","full_name":"Baillie, J. E. M.","first_name":"J. E. M."}],"issue":"7790","article_type":"original","_id":"12599","oa_version":"None","status":"public","language":[{"iso":"eng"}],"publication_status":"published","intvolume":" 577","month":"01","publication":"Nature","publisher":"Springer Nature","day":"16","title":"Importance and vulnerability of the world’s water towers","year":"2020","scopus_import":"1","date_updated":"2023-02-28T12:17:38Z","citation":{"chicago":"Immerzeel, W. W., A. F. Lutz, M. Andrade, A. Bahl, H. Biemans, T. Bolch, S. Hyde, et al. “Importance and Vulnerability of the World’s Water Towers.” Nature. Springer Nature, 2020. https://doi.org/10.1038/s41586-019-1822-y.","apa":"Immerzeel, W. W., Lutz, A. F., Andrade, M., Bahl, A., Biemans, H., Bolch, T., … Baillie, J. E. M. (2020). Importance and vulnerability of the world’s water towers. Nature. Springer Nature. https://doi.org/10.1038/s41586-019-1822-y","short":"W.W. Immerzeel, A.F. Lutz, M. Andrade, A. Bahl, H. Biemans, T. Bolch, S. Hyde, S. Brumby, B.J. Davies, A.C. Elmore, A. Emmer, M. Feng, A. Fernández, U. Haritashya, J.S. Kargel, M. Koppes, P.D.A. Kraaijenbrink, A.V. Kulkarni, P.A. Mayewski, S. Nepal, P. Pacheco, T.H. Painter, F. Pellicciotti, H. Rajaram, S. Rupper, A. Sinisalo, A.B. Shrestha, D. Viviroli, Y. Wada, C. Xiao, T. Yao, J.E.M. Baillie, Nature 577 (2020) 364–369.","mla":"Immerzeel, W. W., et al. “Importance and Vulnerability of the World’s Water Towers.” Nature, vol. 577, no. 7790, Springer Nature, 2020, pp. 364–69, doi:10.1038/s41586-019-1822-y.","ista":"Immerzeel WW, Lutz AF, Andrade M, Bahl A, Biemans H, Bolch T, Hyde S, Brumby S, Davies BJ, Elmore AC, Emmer A, Feng M, Fernández A, Haritashya U, Kargel JS, Koppes M, Kraaijenbrink PDA, Kulkarni AV, Mayewski PA, Nepal S, Pacheco P, Painter TH, Pellicciotti F, Rajaram H, Rupper S, Sinisalo A, Shrestha AB, Viviroli D, Wada Y, Xiao C, Yao T, Baillie JEM. 2020. Importance and vulnerability of the world’s water towers. Nature. 577(7790), 364–369.","ieee":"W. W. Immerzeel et al., “Importance and vulnerability of the world’s water towers,” Nature, vol. 577, no. 7790. Springer Nature, pp. 364–369, 2020.","ama":"Immerzeel WW, Lutz AF, Andrade M, et al. Importance and vulnerability of the world’s water towers. Nature. 2020;577(7790):364-369. doi:10.1038/s41586-019-1822-y"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_published":"2020-01-16T00:00:00Z","doi":"10.1038/s41586-019-1822-y","extern":"1","date_created":"2023-02-20T08:12:53Z","type":"journal_article","volume":577,"publication_identifier":{"eissn":["1476-4687"],"issn":["0028-0836"]}},{"status":"public","oa_version":"Published Version","_id":"12939","month":"08","intvolume":" 2020","publication_status":"published","language":[{"iso":"eng"}],"article_type":"original","quality_controlled":"1","author":[{"first_name":"Cornelia A.","full_name":"Karg, Cornelia A.","last_name":"Karg"},{"full_name":"Wang, Pengyu","first_name":"Pengyu","last_name":"Wang"},{"last_name":"Kluibenschedl","id":"7499e70e-eb2c-11ec-b98b-f925648bc9d9","first_name":"Florian","full_name":"Kluibenschedl, Florian"},{"first_name":"Thomas","full_name":"Müller, Thomas","last_name":"Müller"},{"last_name":"Allmendinger","first_name":"Lars","full_name":"Allmendinger, Lars"},{"first_name":"Angelika M.","full_name":"Vollmar, Angelika M.","last_name":"Vollmar"},{"last_name":"Moser","full_name":"Moser, Simone","first_name":"Simone"}],"article_processing_charge":"No","type":"journal_article","date_created":"2023-05-10T14:49:30Z","publication_identifier":{"issn":["1434-193X","1099-0690"]},"volume":2020,"date_published":"2020-08-09T00:00:00Z","year":"2020","date_updated":"2023-05-15T07:57:14Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","scopus_import":"1","oa":1,"issue":"29","page":"4499-4509","abstract":[{"text":"Linear tetrapyrroles, called phyllobilins, are obtained as major catabolites upon chlorophyll degradation. Primarily, colorless phylloleucobilins featuring four deconjugated pyrrole units were identified. Their yellow counterparts, phylloxanthobilins, were discovered more recently. Although the two catabolites differ only by one double bond, physicochemical properties are very distinct. Moreover, the presence of the double bond seems to enhance physiologically relevant bioactivities: in contrast to phylloleucobilin, we identified a potent anti-proliferative activity for a phylloxanthobilin, and show that this natural product induces apoptotic cell death and a cell cycle arrest in cancer cells. Interestingly, upon modifying inactive phylloleucobilin by esterification, an anti-proliferative activity can be observed that increases with the chain lengths of the alkyl esters. We provide first evidence for anti-cancer activity of phyllobilins, report a novel plant source for a phylloxanthobilin, and by using paper spray MS, show that these bioactive yellow chlorophyll catabolites are more prevalent in Nature than previously assumed.","lang":"eng"}],"keyword":["Organic Chemistry","Physical and Theoretical Chemistry"],"extern":"1","doi":"10.1002/ejoc.202000692","title":"Phylloxanthobilins are abundant linear tetrapyrroles from chlorophyll breakdown with activities against cancer cells","citation":{"ista":"Karg CA, Wang P, Kluibenschedl F, Müller T, Allmendinger L, Vollmar AM, Moser S. 2020. Phylloxanthobilins are abundant linear tetrapyrroles from chlorophyll breakdown with activities against cancer cells. European Journal of Organic Chemistry. 2020(29), 4499–4509.","ieee":"C. A. Karg et al., “Phylloxanthobilins are abundant linear tetrapyrroles from chlorophyll breakdown with activities against cancer cells,” European Journal of Organic Chemistry, vol. 2020, no. 29. Wiley, pp. 4499–4509, 2020.","ama":"Karg CA, Wang P, Kluibenschedl F, et al. Phylloxanthobilins are abundant linear tetrapyrroles from chlorophyll breakdown with activities against cancer cells. European Journal of Organic Chemistry. 2020;2020(29):4499-4509. doi:10.1002/ejoc.202000692","chicago":"Karg, Cornelia A., Pengyu Wang, Florian Kluibenschedl, Thomas Müller, Lars Allmendinger, Angelika M. Vollmar, and Simone Moser. “Phylloxanthobilins Are Abundant Linear Tetrapyrroles from Chlorophyll Breakdown with Activities against Cancer Cells.” European Journal of Organic Chemistry. Wiley, 2020. https://doi.org/10.1002/ejoc.202000692.","short":"C.A. Karg, P. Wang, F. Kluibenschedl, T. Müller, L. Allmendinger, A.M. Vollmar, S. Moser, European Journal of Organic Chemistry 2020 (2020) 4499–4509.","mla":"Karg, Cornelia A., et al. “Phylloxanthobilins Are Abundant Linear Tetrapyrroles from Chlorophyll Breakdown with Activities against Cancer Cells.” European Journal of Organic Chemistry, vol. 2020, no. 29, Wiley, 2020, pp. 4499–509, doi:10.1002/ejoc.202000692.","apa":"Karg, C. A., Wang, P., Kluibenschedl, F., Müller, T., Allmendinger, L., Vollmar, A. M., & Moser, S. (2020). Phylloxanthobilins are abundant linear tetrapyrroles from chlorophyll breakdown with activities against cancer cells. European Journal of Organic Chemistry. Wiley. https://doi.org/10.1002/ejoc.202000692"},"publication":"European Journal of Organic Chemistry","publisher":"Wiley","main_file_link":[{"url":"https://doi.org/10.1002/ejoc.202000692","open_access":"1"}],"day":"09"},{"abstract":[{"text":"Desorption electrospray ionization (DESI), easy ambient sonic-spray ionization (EASI) and low-temperature plasma (LTP) ionization are powerful ambient ionization techniques for mass spectrometry. However, every single method has its limitation in terms of polarity and molecular weight of analyte molecules. After the miniaturization of every possible component of the different ion sources, we finally were able to embed two emitters and an ion transfer tubing into a small, hand-held device. The pen-like interface is connected to the mass spectrometer and a separate control unit via a bundle of flexible tubing and cables. The novel device allows the user to ionize an extended range of chemicals by simple switching between DESI, voltage-free EASI, or LTP ionization as well as to freely move the interface over a surface of interest. A mini camera, which is mounted on the tip of the pen, magnifies the desorption area and enables a simple positioning of the pen. The interface was successfully tested using different types of chemicals, pharmaceuticals, and real life samples. Moreover, the combination of optical data from the camera module and chemical data obtained by mass analysis facilitates a novel type of imaging mass spectrometry, which we name “interactive mass spectrometry imaging (IMSI)”.","lang":"eng"}],"page":"14314-14318","pmid":1,"issue":"21","day":"16","publisher":"American Chemical Society","publication":"Analytical Chemistry","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1021/acs.analchem.0c02615"}],"citation":{"ama":"Meisenbichler C, Kluibenschedl F, Müller T. A 3-in-1 hand-held ambient mass spectrometry interface for identification and 2D localization of chemicals on surfaces. Analytical Chemistry. 2020;92(21):14314-14318. doi:10.1021/acs.analchem.0c02615","ieee":"C. Meisenbichler, F. Kluibenschedl, and T. Müller, “A 3-in-1 hand-held ambient mass spectrometry interface for identification and 2D localization of chemicals on surfaces,” Analytical Chemistry, vol. 92, no. 21. American Chemical Society, pp. 14314–14318, 2020.","ista":"Meisenbichler C, Kluibenschedl F, Müller T. 2020. A 3-in-1 hand-held ambient mass spectrometry interface for identification and 2D localization of chemicals on surfaces. Analytical Chemistry. 92(21), 14314–14318.","apa":"Meisenbichler, C., Kluibenschedl, F., & Müller, T. (2020). A 3-in-1 hand-held ambient mass spectrometry interface for identification and 2D localization of chemicals on surfaces. Analytical Chemistry. American Chemical Society. https://doi.org/10.1021/acs.analchem.0c02615","mla":"Meisenbichler, Christina, et al. “A 3-in-1 Hand-Held Ambient Mass Spectrometry Interface for Identification and 2D Localization of Chemicals on Surfaces.” Analytical Chemistry, vol. 92, no. 21, American Chemical Society, 2020, pp. 14314–18, doi:10.1021/acs.analchem.0c02615.","short":"C. Meisenbichler, F. Kluibenschedl, T. Müller, Analytical Chemistry 92 (2020) 14314–14318.","chicago":"Meisenbichler, Christina, Florian Kluibenschedl, and Thomas Müller. “A 3-in-1 Hand-Held Ambient Mass Spectrometry Interface for Identification and 2D Localization of Chemicals on Surfaces.” Analytical Chemistry. American Chemical Society, 2020. https://doi.org/10.1021/acs.analchem.0c02615."},"title":"A 3-in-1 hand-held ambient mass spectrometry interface for identification and 2D localization of chemicals on surfaces","extern":"1","doi":"10.1021/acs.analchem.0c02615","keyword":["Analytical Chemistry"],"article_processing_charge":"No","author":[{"last_name":"Meisenbichler","first_name":"Christina","full_name":"Meisenbichler, Christina"},{"last_name":"Kluibenschedl","id":"7499e70e-eb2c-11ec-b98b-f925648bc9d9","first_name":"Florian","full_name":"Kluibenschedl, Florian"},{"full_name":"Müller, Thomas","first_name":"Thomas","last_name":"Müller"}],"quality_controlled":"1","article_type":"letter_note","intvolume":" 92","month":"10","external_id":{"pmid":["33063994"]},"publication_status":"published","language":[{"iso":"eng"}],"status":"public","oa_version":"Published Version","_id":"12940","oa":1,"date_updated":"2023-05-15T08:01:20Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","scopus_import":"1","year":"2020","date_published":"2020-10-16T00:00:00Z","publication_identifier":{"issn":["0003-2700","1520-6882"]},"volume":92,"type":"journal_article","date_created":"2023-05-10T14:50:19Z"},{"article_processing_charge":"No","abstract":[{"lang":"eng","text":"We investigate the structural similarities between liquid water and 53 ices, including 20 known crystalline phases. We base such similarity comparison on the local environments that consist of atoms within a certain cutoff radius of a central atom. We reveal that liquid water explores the local environments of the diverse ice phases, by directly comparing the environments in these phases using general atomic descriptors, and also by demonstrating that a machine-learning potential trained on liquid water alone can predict the densities, the lattice energies, and vibrational properties of the\r\nices. The finding that the local environments characterising the different ice phases are found in water sheds light on water phase behaviors, and rationalizes the transferability of water models between different phases."}],"author":[{"full_name":"Monserrat, Bartomeu","first_name":"Bartomeu","last_name":"Monserrat"},{"first_name":"Jan Gerit","full_name":"Brandenburg, Jan Gerit","last_name":"Brandenburg"},{"full_name":"Engel, Edgar A.","first_name":"Edgar A.","last_name":"Engel"},{"id":"cbe3cda4-d82c-11eb-8dc7-8ff94289fcc9","last_name":"Cheng","orcid":"0000-0002-3584-9632","full_name":"Cheng, Bingqing","first_name":"Bingqing"}],"_id":"9699","article_number":"2006.13316","oa_version":"Submitted Version","status":"public","language":[{"iso":"eng"}],"month":"06","publication_status":"submitted","external_id":{"arxiv":["2006.13316"]},"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/2006.13316"}],"publication":"arXiv","day":"23","oa":1,"title":"Extracting ice phases from liquid water: Why a machine-learning water model generalizes so well","year":"2020","citation":{"ieee":"B. Monserrat, J. G. Brandenburg, E. A. Engel, and B. Cheng, “Extracting ice phases from liquid water: Why a machine-learning water model generalizes so well,” arXiv. .","ama":"Monserrat B, Brandenburg JG, Engel EA, Cheng B. Extracting ice phases from liquid water: Why a machine-learning water model generalizes so well. arXiv. doi:10.48550/arXiv.2006.13316","ista":"Monserrat B, Brandenburg JG, Engel EA, Cheng B. Extracting ice phases from liquid water: Why a machine-learning water model generalizes so well. arXiv, 2006.13316.","mla":"Monserrat, Bartomeu, et al. “Extracting Ice Phases from Liquid Water: Why a Machine-Learning Water Model Generalizes so Well.” ArXiv, 2006.13316, doi:10.48550/arXiv.2006.13316.","short":"B. Monserrat, J.G. Brandenburg, E.A. Engel, B. Cheng, ArXiv (n.d.).","apa":"Monserrat, B., Brandenburg, J. G., Engel, E. A., & Cheng, B. (n.d.). Extracting ice phases from liquid water: Why a machine-learning water model generalizes so well. arXiv. https://doi.org/10.48550/arXiv.2006.13316","chicago":"Monserrat, Bartomeu, Jan Gerit Brandenburg, Edgar A. Engel, and Bingqing Cheng. “Extracting Ice Phases from Liquid Water: Why a Machine-Learning Water Model Generalizes so Well.” ArXiv, n.d. https://doi.org/10.48550/arXiv.2006.13316."},"date_updated":"2023-05-10T10:17:48Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","arxiv":1,"date_published":"2020-06-23T00:00:00Z","doi":"10.48550/arXiv.2006.13316","extern":"1","date_created":"2021-07-20T11:25:15Z","type":"preprint"},{"date_created":"2021-07-23T08:59:15Z","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"type":"research_data_reference","doi":"10.6084/m9.figshare.12629697.v1","has_accepted_license":"1","date_published":"2020-07-09T00:00:00Z","user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","date_updated":"2023-08-22T07:55:36Z","citation":{"ista":"Hillary RF, Trejo-Banos D, Kousathanas A, McCartney DL, Harris SE, Stevenson AJ, Patxot M, Ojavee SE, Zhang Q, Liewald DC, Ritchie CW, Evans KL, Tucker-Drob EM, Wray NR, McRae AF, Visscher PM, Deary IJ, Robinson MR, Marioni RE. 2020. Additional file 2 of multi-method genome- and epigenome-wide studies of inflammatory protein levels in healthy older adults, Springer Nature, 10.6084/m9.figshare.12629697.v1.","ieee":"R. F. Hillary et al., “Additional file 2 of multi-method genome- and epigenome-wide studies of inflammatory protein levels in healthy older adults.” Springer Nature, 2020.","ama":"Hillary RF, Trejo-Banos D, Kousathanas A, et al. Additional file 2 of multi-method genome- and epigenome-wide studies of inflammatory protein levels in healthy older adults. 2020. doi:10.6084/m9.figshare.12629697.v1","chicago":"Hillary, Robert F., Daniel Trejo-Banos, Athanasios Kousathanas, Daniel L. McCartney, Sarah E. Harris, Anna J. Stevenson, Marion Patxot, et al. “Additional File 2 of Multi-Method Genome- and Epigenome-Wide Studies of Inflammatory Protein Levels in Healthy Older Adults.” Springer Nature, 2020. https://doi.org/10.6084/m9.figshare.12629697.v1.","mla":"Hillary, Robert F., et al. Additional File 2 of Multi-Method Genome- and Epigenome-Wide Studies of Inflammatory Protein Levels in Healthy Older Adults. Springer Nature, 2020, doi:10.6084/m9.figshare.12629697.v1.","short":"R.F. Hillary, D. Trejo-Banos, A. Kousathanas, D.L. McCartney, S.E. Harris, A.J. Stevenson, M. Patxot, S.E. Ojavee, Q. Zhang, D.C. Liewald, C.W. Ritchie, K.L. Evans, E.M. Tucker-Drob, N.R. Wray, A.F. McRae, P.M. Visscher, I.J. Deary, M.R. Robinson, R.E. Marioni, (2020).","apa":"Hillary, R. F., Trejo-Banos, D., Kousathanas, A., McCartney, D. L., Harris, S. E., Stevenson, A. J., … Marioni, R. E. (2020). Additional file 2 of multi-method genome- and epigenome-wide studies of inflammatory protein levels in healthy older adults. Springer Nature. https://doi.org/10.6084/m9.figshare.12629697.v1"},"year":"2020","related_material":{"record":[{"relation":"used_in_publication","status":"public","id":"8133"}]},"title":"Additional file 2 of multi-method genome- and epigenome-wide studies of inflammatory protein levels in healthy older adults","day":"09","other_data_license":"CC0 + CC BY (4.0)","oa":1,"main_file_link":[{"open_access":"1","url":"https://doi.org/10.6084/m9.figshare.12629697.v1"}],"department":[{"_id":"MaRo"}],"publisher":"Springer Nature","month":"07","oa_version":"Published Version","_id":"9706","status":"public","author":[{"last_name":"Hillary","first_name":"Robert F.","full_name":"Hillary, Robert F."},{"full_name":"Trejo-Banos, Daniel","first_name":"Daniel","last_name":"Trejo-Banos"},{"last_name":"Kousathanas","first_name":"Athanasios","full_name":"Kousathanas, Athanasios"},{"last_name":"McCartney","full_name":"McCartney, Daniel L.","first_name":"Daniel L."},{"last_name":"Harris","first_name":"Sarah E.","full_name":"Harris, Sarah E."},{"last_name":"Stevenson","first_name":"Anna J.","full_name":"Stevenson, Anna J."},{"last_name":"Patxot","full_name":"Patxot, Marion","first_name":"Marion"},{"last_name":"Ojavee","full_name":"Ojavee, Sven Erik","first_name":"Sven Erik"},{"last_name":"Zhang","full_name":"Zhang, Qian","first_name":"Qian"},{"full_name":"Liewald, David C.","first_name":"David C.","last_name":"Liewald"},{"last_name":"Ritchie","first_name":"Craig W.","full_name":"Ritchie, Craig W."},{"last_name":"Evans","full_name":"Evans, Kathryn L.","first_name":"Kathryn L."},{"last_name":"Tucker-Drob","first_name":"Elliot M.","full_name":"Tucker-Drob, Elliot M."},{"full_name":"Wray, Naomi R.","first_name":"Naomi R.","last_name":"Wray"},{"first_name":"Allan F. ","full_name":"McRae, Allan F. ","last_name":"McRae"},{"last_name":"Visscher","full_name":"Visscher, Peter M.","first_name":"Peter M."},{"last_name":"Deary","full_name":"Deary, Ian J.","first_name":"Ian J."},{"first_name":"Matthew Richard","orcid":"0000-0001-8982-8813","full_name":"Robinson, Matthew Richard","last_name":"Robinson","id":"E5D42276-F5DA-11E9-8E24-6303E6697425"},{"last_name":"Marioni","full_name":"Marioni, Riccardo E. ","first_name":"Riccardo E. "}],"abstract":[{"text":"Additional file 2: Supplementary Tables. The association of pre-adjusted protein levels with biological and technical covariates. Protein levels were adjusted for age, sex, array plate and four genetic principal components (population structure) prior to analyses. Significant associations are emboldened. (Table S1). pQTLs associated with inflammatory biomarker levels from Bayesian penalised regression model (Posterior Inclusion Probability > 95%). (Table S2). All pQTLs associated with inflammatory biomarker levels from ordinary least squares regression model (P < 7.14 × 10− 10). (Table S3). Summary of lambda values relating to ordinary least squares GWAS and EWAS performed on inflammatory protein levels (n = 70) in Lothian Birth Cohort 1936 study. (Table S4). Conditionally significant pQTLs associated with inflammatory biomarker levels from ordinary least squares regression model (P < 7.14 × 10− 10). (Table S5). Comparison of variance explained by ordinary least squares and Bayesian penalised regression models for concordantly identified SNPs. (Table S6). Estimate of heritability for blood protein levels as well as proportion of variance explained attributable to different prior mixtures. (Table S7). Comparison of heritability estimates from Ahsan et al. (maximum likelihood) and Hillary et al. (Bayesian penalised regression). (Table S8). List of concordant SNPs identified by linear model and Bayesian penalised regression and whether they have been previously identified as eQTLs. (Table S9). Bayesian tests of colocalisation for cis pQTLs and cis eQTLs. (Table S10). Sherlock algorithm: Genes whose expression are putatively associated with circulating inflammatory proteins that harbour pQTLs. (Table S11). CpGs associated with inflammatory protein biomarkers as identified by Bayesian model (Bayesian model; Posterior Inclusion Probability > 95%). (Table S12). CpGs associated with inflammatory protein biomarkers as identified by linear model (limma) at P < 5.14 × 10− 10. (Table S13). CpGs associated with inflammatory protein biomarkers as identified by mixed linear model (OSCA) at P < 5.14 × 10− 10. (Table S14). Estimate of variance explained for blood protein levels by DNA methylation as well as proportion of explained attributable to different prior mixtures - BayesR+. (Table S15). Comparison of variance in protein levels explained by genome-wide DNA methylation data by mixed linear model (OSCA) and Bayesian penalised regression model (BayesR+). (Table S16). Variance in circulating inflammatory protein biomarker levels explained by common genetic and methylation data (joint and conditional estimates from BayesR+). Ordered by combined variance explained by genetic and epigenetic data - smallest to largest. Significant results from t-tests comparing distributions for variance explained by methylation or genetics alone versus combined estimate are emboldened. (Table S17). Genetic and epigenetic factors identified by BayesR+ when conditioning on all SNPs and CpGs together. (Table S18). Mendelian Randomisation analyses to assess whether proteins with concordantly identified genetic signals are causally associated with Alzheimer’s disease risk. (Table S19).","lang":"eng"}],"article_processing_charge":"No"}]