[{"ddc":["570"],"file":[{"success":1,"file_name":"2021_eLife_Pulgar.pdf","date_updated":"2022-05-13T08:03:37Z","file_id":"11371","file_size":9010446,"date_created":"2022-05-13T08:03:37Z","relation":"main_file","checksum":"a3f82b0499cc822ac1eab48a01f3f57e","access_level":"open_access","creator":"dernst","content_type":"application/pdf"}],"type":"journal_article","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","title":"Apical contacts stemming from incomplete delamination guide progenitor cell allocation through a dragging mechanism","doi":"10.7554/eLife.66483","abstract":[{"text":"The developmental strategies used by progenitor cells to endure a safe journey from their induction place towards the site of terminal differentiation are still poorly understood. Here we uncovered a progenitor cell allocation mechanism that stems from an incomplete process of epithelial delamination that allows progenitors to coordinate their movement with adjacent extra-embryonic tissues. Progenitors of the zebrafish laterality organ originate from the surface epithelial enveloping layer by an apical constriction process of cell delamination. During this process, progenitors retain long-term apical contacts that enable the epithelial layer to pull a subset of progenitors along their way towards the vegetal pole. The remaining delaminated progenitors follow apically-attached progenitors’ movement by a co-attraction mechanism, avoiding sequestration by the adjacent endoderm, ensuring their fate and collective allocation at the differentiation site. Thus, we reveal that incomplete delamination serves as a cellular platform for coordinated tissue movements during development. Impact Statement: Incomplete delamination serves as a cellular platform for coordinated tissue movements during development, guiding newly formed progenitor cell groups to the differentiation site.","lang":"eng"}],"publication":"eLife","article_processing_charge":"Yes","article_number":"e66483","ec_funded":1,"language":[{"iso":"eng"}],"status":"public","oa_version":"Published Version","oa":1,"has_accepted_license":"1","year":"2021","publication_identifier":{"eissn":["2050-084X"]},"publication_status":"published","date_published":"2021-08-27T00:00:00Z","publisher":"eLife Sciences Publications","quality_controlled":"1","department":[{"_id":"CaHe"}],"month":"08","pmid":1,"isi":1,"day":"27","intvolume":"        10","citation":{"mla":"Pulgar, Eduardo, et al. “Apical Contacts Stemming from Incomplete Delamination Guide Progenitor Cell Allocation through a Dragging Mechanism.” <i>ELife</i>, vol. 10, e66483, eLife Sciences Publications, 2021, doi:<a href=\"https://doi.org/10.7554/eLife.66483\">10.7554/eLife.66483</a>.","apa":"Pulgar, E., Schwayer, C., Guerrero, N., López, L., Márquez, S., Härtel, S., … Concha, M. L. (2021). Apical contacts stemming from incomplete delamination guide progenitor cell allocation through a dragging mechanism. <i>ELife</i>. eLife Sciences Publications. <a href=\"https://doi.org/10.7554/eLife.66483\">https://doi.org/10.7554/eLife.66483</a>","short":"E. Pulgar, C. Schwayer, N. Guerrero, L. López, S. Márquez, S. Härtel, R. Soto, C.P. Heisenberg, M.L. Concha, ELife 10 (2021).","ama":"Pulgar E, Schwayer C, Guerrero N, et al. Apical contacts stemming from incomplete delamination guide progenitor cell allocation through a dragging mechanism. <i>eLife</i>. 2021;10. doi:<a href=\"https://doi.org/10.7554/eLife.66483\">10.7554/eLife.66483</a>","ista":"Pulgar E, Schwayer C, Guerrero N, López L, Márquez S, Härtel S, Soto R, Heisenberg CP, Concha ML. 2021. Apical contacts stemming from incomplete delamination guide progenitor cell allocation through a dragging mechanism. eLife. 10, e66483.","chicago":"Pulgar, Eduardo, Cornelia Schwayer, Néstor Guerrero, Loreto López, Susana Márquez, Steffen Härtel, Rodrigo Soto, Carl Philipp Heisenberg, and Miguel L. Concha. “Apical Contacts Stemming from Incomplete Delamination Guide Progenitor Cell Allocation through a Dragging Mechanism.” <i>ELife</i>. eLife Sciences Publications, 2021. <a href=\"https://doi.org/10.7554/eLife.66483\">https://doi.org/10.7554/eLife.66483</a>.","ieee":"E. Pulgar <i>et al.</i>, “Apical contacts stemming from incomplete delamination guide progenitor cell allocation through a dragging mechanism,” <i>eLife</i>, vol. 10. eLife Sciences Publications, 2021."},"project":[{"_id":"260F1432-B435-11E9-9278-68D0E5697425","name":"Interaction and feedback between cell mechanics and fate specification in vertebrate gastrulation","call_identifier":"H2020","grant_number":"742573"}],"scopus_import":"1","external_id":{"isi":["000700428500001"],"pmid":["34448451"]},"_id":"9999","date_created":"2021-09-12T22:01:23Z","file_date_updated":"2022-05-13T08:03:37Z","volume":10,"tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"date_updated":"2023-08-14T06:53:33Z","license":"https://creativecommons.org/licenses/by/4.0/","keyword":["cell delamination","apical constriction","dragging","mechanical forces","collective 18 locomotion","dorsal forerunner cells","zebrafish"],"article_type":"original","author":[{"first_name":"Eduardo","last_name":"Pulgar","full_name":"Pulgar, Eduardo"},{"id":"3436488C-F248-11E8-B48F-1D18A9856A87","last_name":"Schwayer","first_name":"Cornelia","full_name":"Schwayer, Cornelia","orcid":"0000-0001-5130-2226"},{"last_name":"Guerrero","first_name":"Néstor","full_name":"Guerrero, Néstor"},{"full_name":"López, Loreto","last_name":"López","first_name":"Loreto"},{"last_name":"Márquez","first_name":"Susana","full_name":"Márquez, Susana"},{"first_name":"Steffen","last_name":"Härtel","full_name":"Härtel, Steffen"},{"first_name":"Rodrigo","last_name":"Soto","full_name":"Soto, Rodrigo"},{"first_name":"Carl Philipp","last_name":"Heisenberg","full_name":"Heisenberg, Carl Philipp"},{"full_name":"Concha, Miguel L.","first_name":"Miguel L.","last_name":"Concha"}]},{"file_date_updated":"2022-01-26T07:35:17Z","acknowledgement":"This research was supported in part by the Austrian Science Fund (FWF) under grant Z211-N23\r\n(Wittgenstein Award).\r\n","_id":"10672","date_created":"2022-01-25T15:50:00Z","author":[{"last_name":"Lechner","id":"3DC22916-F248-11E8-B48F-1D18A9856A87","first_name":"Mathias","full_name":"Lechner, Mathias"}],"license":"https://creativecommons.org/licenses/by-nc-nd/3.0/","date_updated":"2023-04-03T07:33:40Z","tmp":{"short":"CC BY-NC-ND (3.0)","image":"/images/cc_by_nc_nd.png","name":"Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND 3.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/3.0/legalcode"},"day":"11","month":"03","department":[{"_id":"GradSch"},{"_id":"ToHe"}],"conference":{"name":"ICLR: International Conference on Learning Representations","start_date":"2020-04-26","location":"Virtual ; Addis Ababa, Ethiopia","end_date":"2020-05-01"},"project":[{"call_identifier":"FWF","grant_number":"Z211","_id":"25F42A32-B435-11E9-9278-68D0E5697425","name":"The Wittgenstein Prize"}],"scopus_import":"1","citation":{"ama":"Lechner M. Learning representations for binary-classification without backpropagation. In: <i>8th International Conference on Learning Representations</i>. ICLR; 2020.","ista":"Lechner M. 2020. Learning representations for binary-classification without backpropagation. 8th International Conference on Learning Representations. ICLR: International Conference on Learning Representations.","chicago":"Lechner, Mathias. “Learning Representations for Binary-Classification without Backpropagation.” In <i>8th International Conference on Learning Representations</i>. ICLR, 2020.","apa":"Lechner, M. (2020). Learning representations for binary-classification without backpropagation. In <i>8th International Conference on Learning Representations</i>. Virtual ; Addis Ababa, Ethiopia: ICLR.","mla":"Lechner, Mathias. “Learning Representations for Binary-Classification without Backpropagation.” <i>8th International Conference on Learning Representations</i>, ICLR, 2020.","short":"M. Lechner, in:, 8th International Conference on Learning Representations, ICLR, 2020.","ieee":"M. Lechner, “Learning representations for binary-classification without backpropagation,” in <i>8th International Conference on Learning Representations</i>, Virtual ; Addis Ababa, Ethiopia, 2020."},"oa":1,"has_accepted_license":"1","status":"public","oa_version":"Published Version","language":[{"iso":"eng"}],"article_processing_charge":"No","publisher":"ICLR","quality_controlled":"1","date_published":"2020-03-11T00:00:00Z","year":"2020","publication_status":"published","main_file_link":[{"open_access":"1","url":"https://openreview.net/forum?id=Bke61krFvS"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"conference","title":"Learning representations for binary-classification without backpropagation","file":[{"file_id":"10677","success":1,"file_name":"iclr_2020.pdf","date_updated":"2022-01-26T07:35:17Z","file_size":249431,"relation":"main_file","date_created":"2022-01-26T07:35:17Z","creator":"mlechner","content_type":"application/pdf","access_level":"open_access","checksum":"ea13d42dd4541ddb239b6a75821fd6c9"}],"ddc":["000"],"publication":"8th International Conference on Learning Representations","abstract":[{"lang":"eng","text":"The family of feedback alignment (FA) algorithms aims to provide a more biologically motivated alternative to backpropagation (BP), by substituting the computations that are unrealistic to be implemented in physical brains. While FA algorithms have been shown to work well in practice, there is a lack of rigorous theory proofing their learning capabilities. Here we introduce the first feedback alignment algorithm with provable learning guarantees. In contrast to existing work, we do not require any assumption about the size or depth of the network except that it has a single output neuron, i.e., such as for binary classification tasks. We show that our FA algorithm can deliver its theoretical promises in practice, surpassing the learning performance of existing FA methods and matching backpropagation in binary classification tasks. Finally, we demonstrate the limits of our FA variant when the number of output neurons grows beyond a certain quantity."}]},{"oa_version":"Published Version","status":"public","has_accepted_license":"1","oa":1,"article_processing_charge":"No","alternative_title":["PMLR"],"language":[{"iso":"eng"}],"quality_controlled":"1","series_title":"PMLR","page":"4082-4093","year":"2020","publication_identifier":{"issn":["2640-3498"]},"publication_status":"published","date_published":"2020-01-01T00:00:00Z","title":"A natural lottery ticket winner: Reinforcement learning with ordinary neural circuits","type":"conference","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","main_file_link":[{"open_access":"1","url":"http://proceedings.mlr.press/v119/hasani20a.html"}],"file":[{"file_size":2329798,"date_updated":"2022-01-26T11:08:51Z","file_name":"2020_PMLR_Hasani.pdf","success":1,"file_id":"10691","checksum":"c9a4a29161777fc1a89ef451c040e3b1","access_level":"open_access","creator":"cchlebak","content_type":"application/pdf","relation":"main_file","date_created":"2022-01-26T11:08:51Z"}],"ddc":["000"],"abstract":[{"text":"We propose a neural information processing system obtained by re-purposing the function of a biological neural circuit model to govern simulated and real-world control tasks. Inspired by the structure of the nervous system of the soil-worm, C. elegans, we introduce ordinary neural circuits (ONCs), defined as the model of biological neural circuits reparameterized for the control of alternative tasks. We first demonstrate that ONCs realize networks with higher maximum flow compared to arbitrary wired networks. We then learn instances of ONCs to control a series of robotic tasks, including the autonomous parking of a real-world rover robot. For reconfiguration of the purpose of the neural circuit, we adopt a search-based optimization algorithm. Ordinary neural circuits perform on par and, in some cases, significantly surpass the performance of contemporary deep learning models. ONC networks are compact, 77% sparser than their counterpart neural controllers, and their neural dynamics are fully interpretable at the cell-level.","lang":"eng"}],"publication":"Proceedings of the 37th International Conference on Machine Learning","acknowledgement":"RH and RG are partially supported by Horizon-2020 ECSEL Project grant No. 783163 (iDev40), Productive 4.0, and ATBMBFW CPS-IoT Ecosystem. ML was supported in part by the Austrian Science Fund (FWF) under grant Z211-N23\r\n(Wittgenstein Award). AA is supported by the National Science Foundation (NSF) Graduate Research Fellowship\r\nProgram. RH and DR are partially supported by The Boeing Company and JP Morgan Chase. This research work is\r\npartially drawn from the PhD dissertation of RH.\r\n","file_date_updated":"2022-01-26T11:08:51Z","date_created":"2022-01-25T15:50:34Z","_id":"10673","author":[{"full_name":"Hasani, Ramin","last_name":"Hasani","first_name":"Ramin"},{"last_name":"Lechner","id":"3DC22916-F248-11E8-B48F-1D18A9856A87","first_name":"Mathias","full_name":"Lechner, Mathias"},{"last_name":"Amini","first_name":"Alexander","full_name":"Amini, Alexander"},{"full_name":"Rus, Daniela","last_name":"Rus","first_name":"Daniela"},{"last_name":"Grosu","first_name":"Radu","full_name":"Grosu, Radu"}],"tmp":{"short":"CC BY-NC-ND (3.0)","image":"/images/cc_by_nc_nd.png","name":"Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND 3.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/3.0/legalcode"},"date_updated":"2022-01-26T11:14:27Z","department":[{"_id":"GradSch"},{"_id":"ToHe"}],"citation":{"chicago":"Hasani, Ramin, Mathias Lechner, Alexander Amini, Daniela Rus, and Radu Grosu. “A Natural Lottery Ticket Winner: Reinforcement Learning with Ordinary Neural Circuits.” In <i>Proceedings of the 37th International Conference on Machine Learning</i>, 4082–93. PMLR, 2020.","ama":"Hasani R, Lechner M, Amini A, Rus D, Grosu R. A natural lottery ticket winner: Reinforcement learning with ordinary neural circuits. In: <i>Proceedings of the 37th International Conference on Machine Learning</i>. PMLR. ; 2020:4082-4093.","ista":"Hasani R, Lechner M, Amini A, Rus D, Grosu R. 2020. A natural lottery ticket winner: Reinforcement learning with ordinary neural circuits. Proceedings of the 37th International Conference on Machine Learning. ML: Machine LearningPMLR, PMLR, , 4082–4093.","apa":"Hasani, R., Lechner, M., Amini, A., Rus, D., &#38; Grosu, R. (2020). A natural lottery ticket winner: Reinforcement learning with ordinary neural circuits. In <i>Proceedings of the 37th International Conference on Machine Learning</i> (pp. 4082–4093). Virtual.","short":"R. Hasani, M. Lechner, A. Amini, D. Rus, R. Grosu, in:, Proceedings of the 37th International Conference on Machine Learning, 2020, pp. 4082–4093.","mla":"Hasani, Ramin, et al. “A Natural Lottery Ticket Winner: Reinforcement Learning with Ordinary Neural Circuits.” <i>Proceedings of the 37th International Conference on Machine Learning</i>, 2020, pp. 4082–93.","ieee":"R. Hasani, M. Lechner, A. Amini, D. Rus, and R. Grosu, “A natural lottery ticket winner: Reinforcement learning with ordinary neural circuits,” in <i>Proceedings of the 37th International Conference on Machine Learning</i>, Virtual, 2020, pp. 4082–4093."},"scopus_import":"1","project":[{"grant_number":"Z211","call_identifier":"FWF","_id":"25F42A32-B435-11E9-9278-68D0E5697425","name":"The Wittgenstein Prize"}],"conference":{"location":"Virtual","start_date":"2020-07-12","name":"ML: Machine Learning","end_date":"2020-07-18"}},{"oa":1,"oa_version":"Published Version","extern":"1","status":"public","alternative_title":["Bulletin of the American Physical Society"],"language":[{"iso":"eng"}],"article_number":"B54. 00007","article_processing_charge":"No","quality_controlled":"1","publisher":"American Physical Society","date_published":"2020-03-01T00:00:00Z","publication_status":"published","year":"2020","publication_identifier":{"issn":["0003-0503"]},"main_file_link":[{"url":"https://meetings.aps.org/Meeting/MAR20/Session/B54.7","open_access":"1"}],"title":"Sublattice resolved spin wave transport through graphene fractional quantum Hall states as a probe of isospin order","type":"conference","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","publication":"APS March Meeting 2020","abstract":[{"lang":"eng","text":"High quality graphene heterostructures host an array of fractional quantum Hall isospin ferromagnets with diverse spin and valley orders. While a variety of phase transitions have been observed, disentangling the isospin phase diagram of these states is hampered by the absence of direct probes of spin and valley order. I will describe nonlocal transport measurements based on launching spin waves from a gate defined lateral heterojunction, performed in ultra-clean Corbino geometry graphene devices. At high magnetic fields, we find that the spin-wave transport signal is detected in all FQH states between ν = 0 and 1; however, between ν = 1 and 2 only odd numerator FQH states show finite nonlocal transport, despite the identical ground state spin polarizations in odd- and even numerator states. The results reveal that the neutral spin-waves are both spin and sublattice polarized making them a sensitive probe of ground state sublattice structure. Armed with this understanding, we use nonlocal transport signal to a magnetic field tuned isospin phase transition, showing that the emergent even denominator state at ν = 1/2 in monolayer graphene is indeed a multicomponent state featuring equal populations on each sublattice."}],"volume":65,"issue":"1","date_created":"2022-01-27T10:50:10Z","_id":"10693","author":[{"last_name":"Zhou","first_name":"Haoxin","full_name":"Zhou, Haoxin"},{"orcid":"0000-0001-8223-8896","full_name":"Polshyn, Hryhoriy","last_name":"Polshyn","id":"edfc7cb1-526e-11ec-b05a-e6ecc27e4e48","first_name":"Hryhoriy"},{"first_name":"Takashi","last_name":"Tanaguchi","full_name":"Tanaguchi, Takashi"},{"last_name":"Watanabe","first_name":"Kenji","full_name":"Watanabe, Kenji"},{"first_name":"Andrea","last_name":"Young","full_name":"Young, Andrea"}],"date_updated":"2022-01-27T10:58:38Z","intvolume":"        65","day":"01","month":"03","conference":{"end_date":"2020-03-06","start_date":"2020-03-02","name":"APS: American Physical Society","location":"Denver, CO, United States"},"citation":{"ieee":"H. Zhou, H. Polshyn, T. Tanaguchi, K. Watanabe, and A. Young, “Sublattice resolved spin wave transport through graphene fractional quantum Hall states as a probe of isospin order,” in <i>APS March Meeting 2020</i>, Denver, CO, United States, 2020, vol. 65, no. 1.","mla":"Zhou, Haoxin, et al. “Sublattice Resolved Spin Wave Transport through Graphene Fractional Quantum Hall States as a Probe of Isospin Order.” <i>APS March Meeting 2020</i>, vol. 65, no. 1, B54. 00007, American Physical Society, 2020.","apa":"Zhou, H., Polshyn, H., Tanaguchi, T., Watanabe, K., &#38; Young, A. (2020). Sublattice resolved spin wave transport through graphene fractional quantum Hall states as a probe of isospin order. In <i>APS March Meeting 2020</i> (Vol. 65). Denver, CO, United States: American Physical Society.","short":"H. Zhou, H. Polshyn, T. Tanaguchi, K. Watanabe, A. Young, in:, APS March Meeting 2020, American Physical Society, 2020.","ista":"Zhou H, Polshyn H, Tanaguchi T, Watanabe K, Young A. 2020. Sublattice resolved spin wave transport through graphene fractional quantum Hall states as a probe of isospin order. APS March Meeting 2020. APS: American Physical Society, Bulletin of the American Physical Society, vol. 65, B54. 00007.","ama":"Zhou H, Polshyn H, Tanaguchi T, Watanabe K, Young A. Sublattice resolved spin wave transport through graphene fractional quantum Hall states as a probe of isospin order. In: <i>APS March Meeting 2020</i>. Vol 65. American Physical Society; 2020.","chicago":"Zhou, Haoxin, Hryhoriy Polshyn, Takashi Tanaguchi, Kenji Watanabe, and Andrea Young. “Sublattice Resolved Spin Wave Transport through Graphene Fractional Quantum Hall States as a Probe of Isospin Order.” In <i>APS March Meeting 2020</i>, Vol. 65. American Physical Society, 2020."}},{"publication":"APS March Meeting 2020","abstract":[{"text":"We experimentally investigate twisted van der Waals heterostructures of monolayer graphene rotated with respect to a bernal stacked graphene bilayer. We report transport measurements for devices with twist angles between 0.9 and 1.4°. The electric field allows efficient tuning of the width, isolation and the topology of the moiré bands in this system. By comparing magnetoresistance measurements to numerical simulations, we develop an understanding of the band structure. Finally, we observe correlated states at half- and quarter-fillings, which arise when narrow moire sublattice band is isolated by energy gaps from dispersive bands. We investigate the effects of in-plane and out-of-plane magnetic field on these states and discuss the implication for their spin- and valley- polarization.","lang":"eng"}],"main_file_link":[{"open_access":"1","url":"https://meetings.aps.org/Meeting/MAR20/Session/B51.5"}],"title":"Correlated states and tunable topological bands in twisted monolayer-bilayer graphene heterostructures","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","type":"conference","date_published":"2020-03-01T00:00:00Z","publication_status":"published","year":"2020","publication_identifier":{"issn":["0003-0503"]},"quality_controlled":"1","publisher":"American Physical Society","language":[{"iso":"eng"}],"alternative_title":["Bulletin of the American Physical Society"],"article_number":"B51.00005","article_processing_charge":"No","oa":1,"oa_version":"Published Version","status":"public","extern":"1","conference":{"start_date":"2020-03-02","name":"APS: American Physical Society","location":"Denver, CO, United States","end_date":"2020-03-06"},"citation":{"apa":"Polshyn, H., Zhu, J., Kumar, M., Taniguchi, T., Watanabe, K., MacDonald, A., &#38; Young, A. (2020). Correlated states and tunable topological bands in twisted monolayer-bilayer graphene heterostructures. In <i>APS March Meeting 2020</i> (Vol. 65). Denver, CO, United States: American Physical Society.","mla":"Polshyn, Hryhoriy, et al. “Correlated States and Tunable Topological Bands in Twisted Monolayer-Bilayer Graphene Heterostructures.” <i>APS March Meeting 2020</i>, vol. 65, no. 1, B51.00005, American Physical Society, 2020.","short":"H. Polshyn, J. Zhu, M. Kumar, T. Taniguchi, K. Watanabe, A. MacDonald, A. Young, in:, APS March Meeting 2020, American Physical Society, 2020.","ama":"Polshyn H, Zhu J, Kumar M, et al. Correlated states and tunable topological bands in twisted monolayer-bilayer graphene heterostructures. In: <i>APS March Meeting 2020</i>. Vol 65. American Physical Society; 2020.","chicago":"Polshyn, Hryhoriy, Jihang Zhu, Manish Kumar, Takashi Taniguchi, Kenji Watanabe, Allan MacDonald, and Andrea Young. “Correlated States and Tunable Topological Bands in Twisted Monolayer-Bilayer Graphene Heterostructures.” In <i>APS March Meeting 2020</i>, Vol. 65. American Physical Society, 2020.","ista":"Polshyn H, Zhu J, Kumar M, Taniguchi T, Watanabe K, MacDonald A, Young A. 2020. Correlated states and tunable topological bands in twisted monolayer-bilayer graphene heterostructures. APS March Meeting 2020. APS: American Physical Society, Bulletin of the American Physical Society, vol. 65, B51.00005.","ieee":"H. Polshyn <i>et al.</i>, “Correlated states and tunable topological bands in twisted monolayer-bilayer graphene heterostructures,” in <i>APS March Meeting 2020</i>, Denver, CO, United States, 2020, vol. 65, no. 1."},"month":"03","intvolume":"        65","day":"01","date_updated":"2022-02-08T10:22:08Z","author":[{"full_name":"Polshyn, Hryhoriy","orcid":"0000-0001-8223-8896","id":"edfc7cb1-526e-11ec-b05a-e6ecc27e4e48","last_name":"Polshyn","first_name":"Hryhoriy"},{"first_name":"Jihang","last_name":"Zhu","full_name":"Zhu, Jihang"},{"full_name":"Kumar, Manish","first_name":"Manish","last_name":"Kumar"},{"last_name":"Taniguchi","first_name":"Takashi","full_name":"Taniguchi, Takashi"},{"first_name":"Kenji","last_name":"Watanabe","full_name":"Watanabe, Kenji"},{"full_name":"MacDonald, Allan","last_name":"MacDonald","first_name":"Allan"},{"last_name":"Young","first_name":"Andrea","full_name":"Young, Andrea"}],"date_created":"2022-01-28T10:09:19Z","_id":"10696","volume":65,"issue":"1"},{"publication":"APS March Meeting 2020","abstract":[{"lang":"eng","text":"We report the observation of a quantized anomalous Hall effect in a moiré heterostructure consisting of twisted bilayer graphene aligned to an encapsulating hBN substrate. The effect occurs at a density of 3 electrons per superlattice unit cell, where we observe magnetic hysteresis and a Hall resistance quantized to within 0.1% of the resistance quantum at temperatures as high as 3K. In this first of 3 talks, I will describe the fabrication procedure for our device as well as basic transport characterization measurements. I will introduce the phenomenology of twisted bilayer graphene and present evidence for hBN alignment as manifested in the hierarchy of symmetry-breaking gaps and anomalous magnetoresistance."}],"main_file_link":[{"url":"https://meetings.aps.org/Meeting/MAR20/Session/B59.12","open_access":"1"}],"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","type":"conference","title":"Intrinsic quantized anomalous Hall effect in a moiré heterostructure, part I: Device fabrication and transport","publisher":"American Physical Society","quality_controlled":"1","date_published":"2020-03-01T00:00:00Z","publication_status":"published","year":"2020","oa":1,"status":"public","extern":"1","oa_version":"Published Version","article_number":"B59.00012","related_material":{"record":[{"status":"public","id":"10619","relation":"other"}]},"language":[{"iso":"eng"}],"alternative_title":["Bulletin of the American Physical Society"],"article_processing_charge":"No","external_id":{"arxiv":["1907.00261"]},"conference":{"end_date":"2020-03-06","name":"APS: American Physical Society","start_date":"2020-03-02","location":"Denver, CO, United States"},"citation":{"ieee":"Y. Zhang <i>et al.</i>, “Intrinsic quantized anomalous Hall effect in a moiré heterostructure, part I: Device fabrication and transport,” in <i>APS March Meeting 2020</i>, Denver, CO, United States, 2020, vol. 65, no. 1.","chicago":"Zhang, Yuxuan, Marec Serlin, Charles Tschirhart, Hryhoriy Polshyn, Jiacheng Zhu, Leon Balents, Martin E. Huber, Takashi Taniguchi, Kenji Watanabe, and Andrea Young. “Intrinsic Quantized Anomalous Hall Effect in a Moiré Heterostructure, Part I: Device Fabrication and Transport.” In <i>APS March Meeting 2020</i>, Vol. 65. American Physical Society, 2020.","ista":"Zhang Y, Serlin M, Tschirhart C, Polshyn H, Zhu J, Balents L, Huber ME, Taniguchi T, Watanabe K, Young A. 2020. Intrinsic quantized anomalous Hall effect in a moiré heterostructure, part I: Device fabrication and transport. APS March Meeting 2020. APS: American Physical Society, Bulletin of the American Physical Society, vol. 65, B59.00012.","ama":"Zhang Y, Serlin M, Tschirhart C, et al. Intrinsic quantized anomalous Hall effect in a moiré heterostructure, part I: Device fabrication and transport. In: <i>APS March Meeting 2020</i>. Vol 65. American Physical Society; 2020.","apa":"Zhang, Y., Serlin, M., Tschirhart, C., Polshyn, H., Zhu, J., Balents, L., … Young, A. (2020). Intrinsic quantized anomalous Hall effect in a moiré heterostructure, part I: Device fabrication and transport. In <i>APS March Meeting 2020</i> (Vol. 65). Denver, CO, United States: American Physical Society.","short":"Y. Zhang, M. Serlin, C. Tschirhart, H. Polshyn, J. Zhu, L. Balents, M.E. Huber, T. Taniguchi, K. Watanabe, A. Young, in:, APS March Meeting 2020, American Physical Society, 2020.","mla":"Zhang, Yuxuan, et al. “Intrinsic Quantized Anomalous Hall Effect in a Moiré Heterostructure, Part I: Device Fabrication and Transport.” <i>APS March Meeting 2020</i>, vol. 65, no. 1, B59.00012, American Physical Society, 2020."},"arxiv":1,"day":"01","intvolume":"        65","month":"03","author":[{"full_name":"Zhang, Yuxuan","last_name":"Zhang","first_name":"Yuxuan"},{"full_name":"Serlin, Marec","last_name":"Serlin","first_name":"Marec"},{"first_name":"Charles","last_name":"Tschirhart","full_name":"Tschirhart, Charles"},{"first_name":"Hryhoriy","id":"edfc7cb1-526e-11ec-b05a-e6ecc27e4e48","last_name":"Polshyn","full_name":"Polshyn, Hryhoriy","orcid":"0000-0001-8223-8896"},{"first_name":"Jiacheng","last_name":"Zhu","full_name":"Zhu, Jiacheng"},{"full_name":"Balents, Leon","last_name":"Balents","first_name":"Leon"},{"full_name":"Huber, Martin E.","first_name":"Martin E.","last_name":"Huber"},{"last_name":"Taniguchi","first_name":"Takashi","full_name":"Taniguchi, Takashi"},{"full_name":"Watanabe, Kenji","first_name":"Kenji","last_name":"Watanabe"},{"full_name":"Young, Andrea","first_name":"Andrea","last_name":"Young"}],"date_updated":"2023-02-21T15:57:52Z","issue":"1","acknowledgement":"I would like to thank the MURI program, Sloan foundation, AFOSR, and ARO for their generous support of this work.","volume":65,"_id":"10697","date_created":"2022-01-28T10:28:35Z"},{"year":"2020","publication_status":"published","date_published":"2020-03-01T00:00:00Z","publisher":"American Physical Society","quality_controlled":"1","article_processing_charge":"No","article_number":"B59.00011","language":[{"iso":"eng"}],"related_material":{"record":[{"relation":"other","status":"public","id":"10619"}]},"alternative_title":["Bulletin of the American Physical Society"],"status":"public","extern":"1","oa_version":"Published Version","oa":1,"abstract":[{"text":"This is the second of three talks describing the observation and characterization of a ferromagnetic moiré heterostructure based on twisted bilayer graphene aligned to hexagonal boron nitride. I will compare the qualitative and quantitative features of this observed quantum anomalous Hall state to traditional systems engineered from thin film (Bi,Sb)2Te3 topological insulators. In particular, we find that the measured electronic energy gap of ~30K is several times higher than the Curie temperature, consistent with a lack of disorder associated with magnetic dopants. In this system, the quantization arises from spontaneous ferromagnetic polarization into a single spin and valley moiré subband, which is topological despite the lack of spin orbit coupling. I will also discuss the observation of current induced switching, which allows the magnetic state of the heterostructure to be controllably reversed with currents as small as a few nanoamperes.","lang":"eng"}],"publication":"APS March Meeting 2020","type":"conference","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","title":"Intrinsic quantized anomalous Hall effect in a moiré heterostructure, part II: Temperature dependence and current switching","main_file_link":[{"url":"https://meetings.aps.org/Meeting/MAR20/Session/B59.11","open_access":"1"}],"date_updated":"2023-02-21T15:57:52Z","author":[{"full_name":"Serlin, Marec","first_name":"Marec","last_name":"Serlin"},{"full_name":"Tschirhart, Charles","last_name":"Tschirhart","first_name":"Charles"},{"first_name":"Hryhoriy","last_name":"Polshyn","id":"edfc7cb1-526e-11ec-b05a-e6ecc27e4e48","orcid":"0000-0001-8223-8896","full_name":"Polshyn, Hryhoriy"},{"first_name":"Yuxuan","last_name":"Zhang","full_name":"Zhang, Yuxuan"},{"first_name":"Jiacheng","last_name":"Zhu","full_name":"Zhu, Jiacheng"},{"first_name":"Martin E.","last_name":"Huber","full_name":"Huber, Martin E."},{"last_name":"Balents","first_name":"Leon","full_name":"Balents, Leon"},{"full_name":"Watanabe, Kenji","first_name":"Kenji","last_name":"Watanabe"},{"last_name":"Tanaguchi","first_name":"Takashi","full_name":"Tanaguchi, Takashi"},{"full_name":"Young, Andrea","first_name":"Andrea","last_name":"Young"}],"_id":"10698","date_created":"2022-01-28T10:46:57Z","issue":"1","acknowledgement":"I would like to thank the MURI Program, AFOSR, Sloan Foundation, and the ARO for their generous support of this work.","volume":65,"citation":{"chicago":"Serlin, Marec, Charles Tschirhart, Hryhoriy Polshyn, Yuxuan Zhang, Jiacheng Zhu, Martin E. Huber, Leon Balents, Kenji Watanabe, Takashi Tanaguchi, and Andrea Young. “Intrinsic Quantized Anomalous Hall Effect in a Moiré Heterostructure, Part II: Temperature Dependence and Current Switching.” In <i>APS March Meeting 2020</i>, Vol. 65. American Physical Society, 2020.","ama":"Serlin M, Tschirhart C, Polshyn H, et al. Intrinsic quantized anomalous Hall effect in a moiré heterostructure, part II: Temperature dependence and current switching. In: <i>APS March Meeting 2020</i>. Vol 65. American Physical Society; 2020.","ista":"Serlin M, Tschirhart C, Polshyn H, Zhang Y, Zhu J, Huber ME, Balents L, Watanabe K, Tanaguchi T, Young A. 2020. Intrinsic quantized anomalous Hall effect in a moiré heterostructure, part II: Temperature dependence and current switching. APS March Meeting 2020. APS: American Physical Society, Bulletin of the American Physical Society, vol. 65, B59.00011.","short":"M. Serlin, C. Tschirhart, H. Polshyn, Y. Zhang, J. Zhu, M.E. Huber, L. Balents, K. Watanabe, T. Tanaguchi, A. Young, in:, APS March Meeting 2020, American Physical Society, 2020.","apa":"Serlin, M., Tschirhart, C., Polshyn, H., Zhang, Y., Zhu, J., Huber, M. E., … Young, A. (2020). Intrinsic quantized anomalous Hall effect in a moiré heterostructure, part II: Temperature dependence and current switching. In <i>APS March Meeting 2020</i> (Vol. 65). Denver, CO, United States: American Physical Society.","mla":"Serlin, Marec, et al. “Intrinsic Quantized Anomalous Hall Effect in a Moiré Heterostructure, Part II: Temperature Dependence and Current Switching.” <i>APS March Meeting 2020</i>, vol. 65, no. 1, B59.00011, American Physical Society, 2020.","ieee":"M. Serlin <i>et al.</i>, “Intrinsic quantized anomalous Hall effect in a moiré heterostructure, part II: Temperature dependence and current switching,” in <i>APS March Meeting 2020</i>, Denver, CO, United States, 2020, vol. 65, no. 1."},"conference":{"end_date":"2020-03-06","location":"Denver, CO, United States","name":"APS: American Physical Society","start_date":"2020-03-02"},"external_id":{"arxiv":["1907.00261"]},"month":"03","day":"01","intvolume":"        65","arxiv":1},{"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","type":"conference","title":"Intrinsic quantized anomalous Hall effect in a moiré heterostructure, part III: Scanning probe magnetometry","main_file_link":[{"url":"https://meetings.aps.org/Meeting/MAR20/Session/B59.13","open_access":"1"}],"abstract":[{"text":"This is the third of three talks describing the observation and characterization of a ferromagnetic moiré heterostructure based on twisted bilayer graphene aligned to hexagonal boron nitride. In this segment I will present scanning probe magnetometry data acquired using a nanoSQUID-on-tip microscope, which provides ~150 nm spatial resolution and a field sensitivity of ~10 nT/rtHz. We study the distribution of magnetic domains within the device as a function of density, magnetic field training, and DC current. Our data allow us to constrain the magnitude of the orbital magnetic moment of the electrons in the QAH state. Comparison with simultaneously acquired transport data allows us to precisely correlate single domain dynamics with discrete jumps in the observed anomalous Hall signal.","lang":"eng"}],"publication":"APS March Meeting 2020","status":"public","extern":"1","oa_version":"Published Version","oa":1,"article_processing_charge":"No","article_number":"B59.00013","alternative_title":["Bulletin of the American Physical Society"],"related_material":{"record":[{"id":"10619","status":"public","relation":"other"}]},"language":[{"iso":"eng"}],"publisher":"American Physical Society","quality_controlled":"1","publication_status":"published","publication_identifier":{"issn":["0003-0503"]},"year":"2020","date_published":"2020-03-01T00:00:00Z","day":"01","intvolume":"        65","arxiv":1,"month":"03","external_id":{"arxiv":["1907.00261"]},"citation":{"mla":"Tschirhart, Charles, et al. “Intrinsic Quantized Anomalous Hall Effect in a Moiré Heterostructure, Part III: Scanning Probe Magnetometry.” <i>APS March Meeting 2020</i>, vol. 65, no. 1, B59.00013, American Physical Society, 2020.","apa":"Tschirhart, C., Serlin, M., Polshyn, H., Zhang, Y., Zhu, J., Balents, L., … Young, A. (2020). Intrinsic quantized anomalous Hall effect in a moiré heterostructure, part III: Scanning probe magnetometry. In <i>APS March Meeting 2020</i> (Vol. 65). Denver, CO, United States: American Physical Society.","short":"C. Tschirhart, M. Serlin, H. Polshyn, Y. Zhang, J. Zhu, L. Balents, M.E. Huber, K. Watanabe, T. Tanaguchi, A. Young, in:, APS March Meeting 2020, American Physical Society, 2020.","ista":"Tschirhart C, Serlin M, Polshyn H, Zhang Y, Zhu J, Balents L, Huber ME, Watanabe K, Tanaguchi T, Young A. 2020. Intrinsic quantized anomalous Hall effect in a moiré heterostructure, part III: Scanning probe magnetometry. APS March Meeting 2020. APS: American Physical Society, Bulletin of the American Physical Society, vol. 65, B59.00013.","chicago":"Tschirhart, Charles, Marec Serlin, Hryhoriy Polshyn, Yuxuan Zhang, Jiacheng Zhu, Leon Balents, Martin E. Huber, Kenji Watanabe, Takashi Tanaguchi, and Andrea Young. “Intrinsic Quantized Anomalous Hall Effect in a Moiré Heterostructure, Part III: Scanning Probe Magnetometry.” In <i>APS March Meeting 2020</i>, Vol. 65. American Physical Society, 2020.","ama":"Tschirhart C, Serlin M, Polshyn H, et al. Intrinsic quantized anomalous Hall effect in a moiré heterostructure, part III: Scanning probe magnetometry. In: <i>APS March Meeting 2020</i>. Vol 65. American Physical Society; 2020.","ieee":"C. Tschirhart <i>et al.</i>, “Intrinsic quantized anomalous Hall effect in a moiré heterostructure, part III: Scanning probe magnetometry,” in <i>APS March Meeting 2020</i>, Denver, CO, United States, 2020, vol. 65, no. 1."},"conference":{"end_date":"2020-03-06","start_date":"2020-03-02","name":"APS: American Physical Society","location":"Denver, CO, United States"},"issue":"1","acknowledgement":"I would like to thank the MURI program, Sloan foundation, AFOSR, and ARO for their generous support of this work. I would also like to thank the NSF GRFP and the Hertz foundation for their generous support of my graduate studies.","volume":65,"_id":"10699","date_created":"2022-01-28T10:57:49Z","author":[{"first_name":"Charles","last_name":"Tschirhart","full_name":"Tschirhart, Charles"},{"full_name":"Serlin, Marec","last_name":"Serlin","first_name":"Marec"},{"first_name":"Hryhoriy","last_name":"Polshyn","id":"edfc7cb1-526e-11ec-b05a-e6ecc27e4e48","orcid":"0000-0001-8223-8896","full_name":"Polshyn, Hryhoriy"},{"full_name":"Zhang, Yuxuan","first_name":"Yuxuan","last_name":"Zhang"},{"full_name":"Zhu, Jiacheng","first_name":"Jiacheng","last_name":"Zhu"},{"full_name":"Balents, Leon","last_name":"Balents","first_name":"Leon"},{"full_name":"Huber, Martin E.","first_name":"Martin E.","last_name":"Huber"},{"full_name":"Watanabe, Kenji","first_name":"Kenji","last_name":"Watanabe"},{"full_name":"Tanaguchi, Takashi","first_name":"Takashi","last_name":"Tanaguchi"},{"full_name":"Young, Andrea","first_name":"Andrea","last_name":"Young"}],"date_updated":"2023-02-21T15:57:52Z"},{"page":"154-158","publisher":"Springer Nature","quality_controlled":"1","date_published":"2020-02-01T00:00:00Z","publication_identifier":{"eissn":["1745-2481"],"issn":["1745-2473"]},"year":"2020","publication_status":"published","oa":1,"status":"public","extern":"1","oa_version":"Preprint","language":[{"iso":"eng"}],"article_processing_charge":"No","publication":"Nature Physics","abstract":[{"lang":"eng","text":"Partially filled Landau levels host competing electronic orders. For example, electron solids may prevail close to integer filling of the Landau levels before giving way to fractional quantum Hall liquids at higher carrier density1,2. Here, we report the observation of an electron solid with non-collinear spin texture in monolayer graphene, consistent with solidification of skyrmions3—topological spin textures characterized by quantized electrical charge4,5. We probe the spin texture of the solids using a modified Corbino geometry that allows ferromagnetic magnons to be launched and detected6,7. We find that magnon transport is highly efficient when one Landau level is filled (ν=1), consistent with quantum Hall ferromagnetic spin polarization. However, even minimal doping immediately quenches the magnon signal while leaving the vanishing low-temperature charge conductivity unchanged. Our results can be understood by the formation of a solid of charged skyrmions near ν=1, whose non-collinear spin texture leads to rapid magnon decay. Data near fractional fillings show evidence of several fractional skyrmion solids, suggesting that graphene hosts a highly tunable landscape of coupled spin and charge orders."}],"doi":"10.1038/s41567-019-0729-8","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1904.11485"}],"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","type":"journal_article","title":"Skyrmion solids in monolayer graphene","author":[{"first_name":"Haoxin","last_name":"Zhou","full_name":"Zhou, Haoxin"},{"first_name":"Hryhoriy","id":"edfc7cb1-526e-11ec-b05a-e6ecc27e4e48","last_name":"Polshyn","full_name":"Polshyn, Hryhoriy","orcid":"0000-0001-8223-8896"},{"first_name":"Takashi","last_name":"Taniguchi","full_name":"Taniguchi, Takashi"},{"last_name":"Watanabe","first_name":"Kenji","full_name":"Watanabe, Kenji"},{"full_name":"Young, Andrea F.","last_name":"Young","first_name":"Andrea F."}],"article_type":"original","date_updated":"2022-01-31T07:10:07Z","issue":"2","acknowledgement":"We acknowledge discussions with B. Halperin, C. Huang, A. Macdonald and M. Zalatel. Experimental work at UCSB was supported by the Army Research Office under awards nos. MURI W911NF-16-1-0361 and W911NF-16-1-0482. K.W. and T.T. acknowledge support from the Elemental Strategy Initiative conducted by MEXT (Japan) and CREST (JPMJCR15F3), JST. A.F.Y. acknowledges the support of the David and Lucile Packard Foundation and and Alfred. P. Sloan Foundation.","volume":16,"_id":"10701","date_created":"2022-01-28T12:04:09Z","external_id":{"arxiv":["1904.11485"]},"citation":{"ieee":"H. Zhou, H. Polshyn, T. Taniguchi, K. Watanabe, and A. F. Young, “Skyrmion solids in monolayer graphene,” <i>Nature Physics</i>, vol. 16, no. 2. Springer Nature, pp. 154–158, 2020.","mla":"Zhou, Haoxin, et al. “Skyrmion Solids in Monolayer Graphene.” <i>Nature Physics</i>, vol. 16, no. 2, Springer Nature, 2020, pp. 154–58, doi:<a href=\"https://doi.org/10.1038/s41567-019-0729-8\">10.1038/s41567-019-0729-8</a>.","short":"H. Zhou, H. Polshyn, T. Taniguchi, K. Watanabe, A.F. Young, Nature Physics 16 (2020) 154–158.","apa":"Zhou, H., Polshyn, H., Taniguchi, T., Watanabe, K., &#38; Young, A. F. (2020). Skyrmion solids in monolayer graphene. <i>Nature Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41567-019-0729-8\">https://doi.org/10.1038/s41567-019-0729-8</a>","ista":"Zhou H, Polshyn H, Taniguchi T, Watanabe K, Young AF. 2020. Skyrmion solids in monolayer graphene. Nature Physics. 16(2), 154–158.","ama":"Zhou H, Polshyn H, Taniguchi T, Watanabe K, Young AF. Skyrmion solids in monolayer graphene. <i>Nature Physics</i>. 2020;16(2):154-158. doi:<a href=\"https://doi.org/10.1038/s41567-019-0729-8\">10.1038/s41567-019-0729-8</a>","chicago":"Zhou, Haoxin, Hryhoriy Polshyn, Takashi Taniguchi, Kenji Watanabe, and Andrea F. Young. “Skyrmion Solids in Monolayer Graphene.” <i>Nature Physics</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41567-019-0729-8\">https://doi.org/10.1038/s41567-019-0729-8</a>."},"arxiv":1,"day":"01","intvolume":"        16","month":"02"},{"status":"public","oa_version":"None","article_processing_charge":"No","language":[{"iso":"eng"}],"related_material":{"record":[{"id":"299","status":"public","relation":"earlier_version"}]},"publisher":"Springer Nature","quality_controlled":"1","page":"741-758","publication_identifier":{"issn":["1433-2779"],"eissn":["1433-2787"]},"year":"2020","publication_status":"published","date_published":"2020-08-03T00:00:00Z","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","type":"journal_article","title":"AMT 2.0: Qualitative and quantitative trace analysis with extended signal temporal logic","abstract":[{"text":"We introduce in this paper AMT2.0, a tool for qualitative and quantitative analysis of hybrid continuous and Boolean signals that combine numerical values and discrete events. The evaluation of the signals is based on rich temporal specifications expressed in extended signal temporal logic, which integrates timed regular expressions within signal temporal logic. The tool features qualitative monitoring (property satisfaction checking), trace diagnostics for explaining and justifying property violations and specification-driven measurement of quantitative features of the signal. We demonstrate the tool functionality on several running examples and case studies, and evaluate its performance.","lang":"eng"}],"publication":"International Journal on Software Tools for Technology Transfer","doi":"10.1007/s10009-020-00582-z","issue":"6","volume":22,"_id":"10861","date_created":"2022-03-18T10:10:53Z","article_type":"original","keyword":["Information Systems","Software"],"author":[{"full_name":"Nickovic, Dejan","last_name":"Nickovic","id":"41BCEE5C-F248-11E8-B48F-1D18A9856A87","first_name":"Dejan"},{"first_name":"Olivier","last_name":"Lebeltel","full_name":"Lebeltel, Olivier"},{"full_name":"Maler, Oded","last_name":"Maler","first_name":"Oded"},{"orcid":"0000-0001-5199-3143","full_name":"Ferrere, Thomas","first_name":"Thomas","last_name":"Ferrere","id":"40960E6E-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Dogan","last_name":"Ulus","full_name":"Ulus, Dogan"}],"date_updated":"2023-09-08T11:52:02Z","day":"03","intvolume":"        22","month":"08","department":[{"_id":"ToHe"}],"isi":1,"external_id":{"isi":["000555398600001"]},"citation":{"short":"D. Nickovic, O. Lebeltel, O. Maler, T. Ferrere, D. Ulus, International Journal on Software Tools for Technology Transfer 22 (2020) 741–758.","apa":"Nickovic, D., Lebeltel, O., Maler, O., Ferrere, T., &#38; Ulus, D. (2020). AMT 2.0: Qualitative and quantitative trace analysis with extended signal temporal logic. <i>International Journal on Software Tools for Technology Transfer</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s10009-020-00582-z\">https://doi.org/10.1007/s10009-020-00582-z</a>","mla":"Nickovic, Dejan, et al. “AMT 2.0: Qualitative and Quantitative Trace Analysis with Extended Signal Temporal Logic.” <i>International Journal on Software Tools for Technology Transfer</i>, vol. 22, no. 6, Springer Nature, 2020, pp. 741–58, doi:<a href=\"https://doi.org/10.1007/s10009-020-00582-z\">10.1007/s10009-020-00582-z</a>.","ama":"Nickovic D, Lebeltel O, Maler O, Ferrere T, Ulus D. AMT 2.0: Qualitative and quantitative trace analysis with extended signal temporal logic. <i>International Journal on Software Tools for Technology Transfer</i>. 2020;22(6):741-758. doi:<a href=\"https://doi.org/10.1007/s10009-020-00582-z\">10.1007/s10009-020-00582-z</a>","chicago":"Nickovic, Dejan, Olivier Lebeltel, Oded Maler, Thomas Ferrere, and Dogan Ulus. “AMT 2.0: Qualitative and Quantitative Trace Analysis with Extended Signal Temporal Logic.” <i>International Journal on Software Tools for Technology Transfer</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1007/s10009-020-00582-z\">https://doi.org/10.1007/s10009-020-00582-z</a>.","ista":"Nickovic D, Lebeltel O, Maler O, Ferrere T, Ulus D. 2020. AMT 2.0: Qualitative and quantitative trace analysis with extended signal temporal logic. International Journal on Software Tools for Technology Transfer. 22(6), 741–758.","ieee":"D. Nickovic, O. Lebeltel, O. Maler, T. Ferrere, and D. Ulus, “AMT 2.0: Qualitative and quantitative trace analysis with extended signal temporal logic,” <i>International Journal on Software Tools for Technology Transfer</i>, vol. 22, no. 6. Springer Nature, pp. 741–758, 2020."},"scopus_import":"1"},{"publication":"Journal of Functional Analysis","abstract":[{"text":"We consider the sum of two large Hermitian matrices A and B with a Haar unitary conjugation bringing them into a general relative position. We prove that the eigenvalue density on the scale slightly above the local eigenvalue spacing is asymptotically given by the free additive convolution of the laws of A and B as the dimension of the matrix increases. This implies optimal rigidity of the eigenvalues and optimal rate of convergence in Voiculescu's theorem. Our previous works [4], [5] established these results in the bulk spectrum, the current paper completely settles the problem at the spectral edges provided they have the typical square-root behavior. The key element of our proof is to compensate the deterioration of the stability of the subordination equations by sharp error estimates that properly account for the local density near the edge. Our results also hold if the Haar unitary matrix is replaced by the Haar orthogonal matrix.","lang":"eng"}],"doi":"10.1016/j.jfa.2020.108639","main_file_link":[{"url":"https://arxiv.org/abs/1708.01597","open_access":"1"}],"type":"journal_article","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","title":"Spectral rigidity for addition of random matrices at the regular edge","publisher":"Elsevier","quality_controlled":"1","date_published":"2020-10-15T00:00:00Z","publication_identifier":{"issn":["0022-1236"]},"year":"2020","publication_status":"published","oa":1,"status":"public","oa_version":"Preprint","article_number":"108639","ec_funded":1,"language":[{"iso":"eng"}],"article_processing_charge":"No","external_id":{"isi":["000559623200009"],"arxiv":["1708.01597"]},"project":[{"_id":"258DCDE6-B435-11E9-9278-68D0E5697425","name":"Random matrices, universality and disordered quantum systems","call_identifier":"FP7","grant_number":"338804"}],"scopus_import":"1","citation":{"ieee":"Z. Bao, L. Erdös, and K. Schnelli, “Spectral rigidity for addition of random matrices at the regular edge,” <i>Journal of Functional Analysis</i>, vol. 279, no. 7. Elsevier, 2020.","ista":"Bao Z, Erdös L, Schnelli K. 2020. Spectral rigidity for addition of random matrices at the regular edge. Journal of Functional Analysis. 279(7), 108639.","ama":"Bao Z, Erdös L, Schnelli K. Spectral rigidity for addition of random matrices at the regular edge. <i>Journal of Functional Analysis</i>. 2020;279(7). doi:<a href=\"https://doi.org/10.1016/j.jfa.2020.108639\">10.1016/j.jfa.2020.108639</a>","chicago":"Bao, Zhigang, László Erdös, and Kevin Schnelli. “Spectral Rigidity for Addition of Random Matrices at the Regular Edge.” <i>Journal of Functional Analysis</i>. Elsevier, 2020. <a href=\"https://doi.org/10.1016/j.jfa.2020.108639\">https://doi.org/10.1016/j.jfa.2020.108639</a>.","short":"Z. Bao, L. Erdös, K. Schnelli, Journal of Functional Analysis 279 (2020).","mla":"Bao, Zhigang, et al. “Spectral Rigidity for Addition of Random Matrices at the Regular Edge.” <i>Journal of Functional Analysis</i>, vol. 279, no. 7, 108639, Elsevier, 2020, doi:<a href=\"https://doi.org/10.1016/j.jfa.2020.108639\">10.1016/j.jfa.2020.108639</a>.","apa":"Bao, Z., Erdös, L., &#38; Schnelli, K. (2020). Spectral rigidity for addition of random matrices at the regular edge. <i>Journal of Functional Analysis</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.jfa.2020.108639\">https://doi.org/10.1016/j.jfa.2020.108639</a>"},"arxiv":1,"day":"15","intvolume":"       279","month":"10","department":[{"_id":"LaEr"}],"isi":1,"article_type":"original","keyword":["Analysis"],"author":[{"full_name":"Bao, Zhigang","orcid":"0000-0003-3036-1475","id":"442E6A6C-F248-11E8-B48F-1D18A9856A87","last_name":"Bao","first_name":"Zhigang"},{"full_name":"Erdös, László","orcid":"0000-0001-5366-9603","first_name":"László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","last_name":"Erdös"},{"last_name":"Schnelli","first_name":"Kevin","full_name":"Schnelli, Kevin"}],"date_updated":"2023-08-24T14:08:42Z","issue":"7","volume":279,"acknowledgement":"Partially supported by ERC Advanced Grant RANMAT No. 338804.","_id":"10862","date_created":"2022-03-18T10:18:59Z"},{"month":"04","place":"Cham","day":"29","intvolume":"     12110","scopus_import":"1","citation":{"short":"S. Chakraborty, M. Prabhakaran, D. Wichs, in:, A. Kiayias (Ed.), Public-Key Cryptography, Springer Nature, Cham, 2020, pp. 220–246.","apa":"Chakraborty, S., Prabhakaran, M., &#38; Wichs, D. (2020). Witness maps and applications. In A. Kiayias (Ed.), <i>Public-Key Cryptography</i> (Vol. 12110, pp. 220–246). Cham: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-030-45374-9_8\">https://doi.org/10.1007/978-3-030-45374-9_8</a>","mla":"Chakraborty, Suvradip, et al. “Witness Maps and Applications.” <i>Public-Key Cryptography</i>, edited by A Kiayias, vol. 12110, Springer Nature, 2020, pp. 220–46, doi:<a href=\"https://doi.org/10.1007/978-3-030-45374-9_8\">10.1007/978-3-030-45374-9_8</a>.","ista":"Chakraborty S, Prabhakaran M, Wichs D. 2020.Witness maps and applications. In: Public-Key Cryptography. vol. 12110, 220–246.","ama":"Chakraborty S, Prabhakaran M, Wichs D. Witness maps and applications. In: Kiayias A, ed. <i>Public-Key Cryptography</i>. Vol 12110. LNCS. Cham: Springer Nature; 2020:220-246. doi:<a href=\"https://doi.org/10.1007/978-3-030-45374-9_8\">10.1007/978-3-030-45374-9_8</a>","chicago":"Chakraborty, Suvradip, Manoj Prabhakaran, and Daniel Wichs. “Witness Maps and Applications.” In <i>Public-Key Cryptography</i>, edited by A Kiayias, 12110:220–46. LNCS. Cham: Springer Nature, 2020. <a href=\"https://doi.org/10.1007/978-3-030-45374-9_8\">https://doi.org/10.1007/978-3-030-45374-9_8</a>.","ieee":"S. Chakraborty, M. Prabhakaran, and D. Wichs, “Witness maps and applications,” in <i>Public-Key Cryptography</i>, vol. 12110, A. Kiayias, Ed. Cham: Springer Nature, 2020, pp. 220–246."},"editor":[{"full_name":"Kiayias, A","first_name":"A","last_name":"Kiayias"}],"_id":"10865","date_created":"2022-03-18T11:35:51Z","acknowledgement":"We would like to thank the anonymous reviewers of PKC 2019 for their useful comments and suggestions. We thank Omer Paneth for pointing out to us the connection between Unique Witness Maps (UWM) and Witness encryption (WE). The first author would like to acknowledge Pandu Rangan for his involvement during the initial discussion phase of the project.","volume":12110,"date_updated":"2023-09-05T15:10:02Z","author":[{"id":"B9CD0494-D033-11E9-B219-A439E6697425","last_name":"Chakraborty","first_name":"Suvradip","full_name":"Chakraborty, Suvradip"},{"first_name":"Manoj","last_name":"Prabhakaran","full_name":"Prabhakaran, Manoj"},{"full_name":"Wichs, Daniel","last_name":"Wichs","first_name":"Daniel"}],"main_file_link":[{"url":"https://eprint.iacr.org/2020/090","open_access":"1"}],"type":"book_chapter","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","title":"Witness maps and applications","doi":"10.1007/978-3-030-45374-9_8","publication":"Public-Key Cryptography","abstract":[{"lang":"eng","text":"We introduce the notion of Witness Maps as a cryptographic notion of a proof system. A Unique Witness Map (UWM) deterministically maps all witnesses for an   NP  statement to a single representative witness, resulting in a computationally sound, deterministic-prover, non-interactive witness independent proof system. A relaxation of UWM, called Compact Witness Map (CWM), maps all the witnesses to a small number of witnesses, resulting in a “lossy” deterministic-prover, non-interactive proof-system. We also define a Dual Mode Witness Map (DMWM) which adds an “extractable” mode to a CWM.\r\nOur main construction is a DMWM for all   NP  relations, assuming sub-exponentially secure indistinguishability obfuscation (  iO ), along with standard cryptographic assumptions. The DMWM construction relies on a CWM and a new primitive called Cumulative All-Lossy-But-One Trapdoor Functions (C-ALBO-TDF), both of which are in turn instantiated based on   iO  and other primitives. Our instantiation of a CWM is in fact a UWM; in turn, we show that a UWM implies Witness Encryption. Along the way to constructing UWM and C-ALBO-TDF, we also construct, from standard assumptions, Puncturable Digital Signatures and a new primitive called Cumulative Lossy Trapdoor Functions (C-LTDF). The former improves up on a construction of Bellare et al. (Eurocrypt 2016), who relied on sub-exponentially secure   iO  and sub-exponentially secure OWF.\r\nAs an application of our constructions, we show how to use a DMWM to construct the first leakage and tamper-resilient signatures with a deterministic signer, thereby solving a decade old open problem posed by Katz and Vaikunthanathan (Asiacrypt 2009), by Boyle, Segev and Wichs (Eurocrypt 2011), as well as by Faonio and Venturi (Asiacrypt 2016). Our construction achieves the optimal leakage rate of   1−o(1) ."}],"language":[{"iso":"eng"}],"article_processing_charge":"No","oa":1,"status":"public","oa_version":"Preprint","date_published":"2020-04-29T00:00:00Z","year":"2020","publication_identifier":{"issn":["0302-9743"],"eissn":["1611-3349"],"isbn":["9783030453732","9783030453749"]},"publication_status":"published","series_title":"LNCS","page":"220-246","publisher":"Springer Nature","quality_controlled":"1"},{"keyword":["Mechanical Engineering","Condensed Matter Physics","General Materials Science","General Chemistry","Bioengineering"],"article_type":"original","author":[{"full_name":"Duan, Jiahua","last_name":"Duan","first_name":"Jiahua"},{"first_name":"Nathaniel","last_name":"Capote-Robayna","full_name":"Capote-Robayna, Nathaniel"},{"last_name":"Taboada-Gutiérrez","first_name":"Javier","full_name":"Taboada-Gutiérrez, Javier"},{"full_name":"Álvarez-Pérez, Gonzalo","last_name":"Álvarez-Pérez","first_name":"Gonzalo"},{"orcid":"0000-0002-7370-5357","full_name":"Prieto Gonzalez, Ivan","first_name":"Ivan","last_name":"Prieto Gonzalez","id":"2A307FE2-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Javier","last_name":"Martín-Sánchez","full_name":"Martín-Sánchez, Javier"},{"last_name":"Nikitin","first_name":"Alexey Y.","full_name":"Nikitin, Alexey Y."},{"full_name":"Alonso-González, Pablo","last_name":"Alonso-González","first_name":"Pablo"}],"date_updated":"2023-09-05T12:05:58Z","issue":"7","volume":20,"acknowledgement":"J.T.-G. and G.Á.-P. acknowledge support through the Severo Ochoa Program from the\r\nGovernment of the Principality of Asturias (nos. PA-18-PF-BP17-126 and PA20-PF-BP19-053,\r\nrespectively). J. M-S acknowledges financial support through the Ramón y Cajal Program from\r\nthe Government of Spain (RYC2018-026196-I). A.Y.N. acknowledges the Spanish Ministry of\r\nScience, Innovation and Universities (national project no. MAT201788358-C3-3-R). P.A.-G.\r\nacknowledges support from the European Research Council under starting grant no. 715496,\r\n2DNANOPTICA.","_id":"10866","date_created":"2022-03-18T11:37:38Z","external_id":{"isi":["000548893200082"],"pmid":["32530634"],"arxiv":["2004.14599"]},"scopus_import":"1","citation":{"ieee":"J. Duan <i>et al.</i>, “Twisted nano-optics: Manipulating light at the nanoscale with twisted phonon polaritonic slabs,” <i>Nano Letters</i>, vol. 20, no. 7. American Chemical Society, pp. 5323–5329, 2020.","ama":"Duan J, Capote-Robayna N, Taboada-Gutiérrez J, et al. Twisted nano-optics: Manipulating light at the nanoscale with twisted phonon polaritonic slabs. <i>Nano Letters</i>. 2020;20(7):5323-5329. doi:<a href=\"https://doi.org/10.1021/acs.nanolett.0c01673\">10.1021/acs.nanolett.0c01673</a>","ista":"Duan J, Capote-Robayna N, Taboada-Gutiérrez J, Álvarez-Pérez G, Prieto Gonzalez I, Martín-Sánchez J, Nikitin AY, Alonso-González P. 2020. Twisted nano-optics: Manipulating light at the nanoscale with twisted phonon polaritonic slabs. Nano Letters. 20(7), 5323–5329.","chicago":"Duan, Jiahua, Nathaniel Capote-Robayna, Javier Taboada-Gutiérrez, Gonzalo Álvarez-Pérez, Ivan Prieto Gonzalez, Javier Martín-Sánchez, Alexey Y. Nikitin, and Pablo Alonso-González. “Twisted Nano-Optics: Manipulating Light at the Nanoscale with Twisted Phonon Polaritonic Slabs.” <i>Nano Letters</i>. American Chemical Society, 2020. <a href=\"https://doi.org/10.1021/acs.nanolett.0c01673\">https://doi.org/10.1021/acs.nanolett.0c01673</a>.","short":"J. Duan, N. Capote-Robayna, J. Taboada-Gutiérrez, G. Álvarez-Pérez, I. Prieto Gonzalez, J. Martín-Sánchez, A.Y. Nikitin, P. Alonso-González, Nano Letters 20 (2020) 5323–5329.","apa":"Duan, J., Capote-Robayna, N., Taboada-Gutiérrez, J., Álvarez-Pérez, G., Prieto Gonzalez, I., Martín-Sánchez, J., … Alonso-González, P. (2020). Twisted nano-optics: Manipulating light at the nanoscale with twisted phonon polaritonic slabs. <i>Nano Letters</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acs.nanolett.0c01673\">https://doi.org/10.1021/acs.nanolett.0c01673</a>","mla":"Duan, Jiahua, et al. “Twisted Nano-Optics: Manipulating Light at the Nanoscale with Twisted Phonon Polaritonic Slabs.” <i>Nano Letters</i>, vol. 20, no. 7, American Chemical Society, 2020, pp. 5323–29, doi:<a href=\"https://doi.org/10.1021/acs.nanolett.0c01673\">10.1021/acs.nanolett.0c01673</a>."},"arxiv":1,"day":"01","intvolume":"        20","month":"07","department":[{"_id":"NanoFab"}],"isi":1,"pmid":1,"page":"5323-5329","publisher":"American Chemical Society","quality_controlled":"1","date_published":"2020-07-01T00:00:00Z","year":"2020","publication_status":"published","publication_identifier":{"issn":["1530-6984"],"eissn":["1530-6992"]},"oa":1,"status":"public","oa_version":"Preprint","language":[{"iso":"eng"}],"article_processing_charge":"No","publication":"Nano Letters","abstract":[{"text":"Recent discoveries have shown that, when two layers of van der Waals (vdW) materials are superimposed with a relative twist angle between them, the electronic properties of the coupled system can be dramatically altered. Here, we demonstrate that a similar concept can be extended to the optics realm, particularly to propagating phonon polaritons–hybrid light-matter interactions. To do this, we fabricate stacks composed of two twisted slabs of a vdW crystal (α-MoO3) supporting anisotropic phonon polaritons (PhPs), and image the propagation of the latter when launched by localized sources. Our images reveal that, under a critical angle, the PhPs isofrequency curve undergoes a topological transition, in which the propagation of PhPs is strongly guided (canalization regime) along predetermined directions without geometric spreading. These results demonstrate a new degree of freedom (twist angle) for controlling the propagation of polaritons at the nanoscale with potential for nanoimaging, (bio)-sensing, or heat management.","lang":"eng"}],"doi":"10.1021/acs.nanolett.0c01673","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/2004.14599"}],"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","type":"journal_article","title":"Twisted nano-optics: Manipulating light at the nanoscale with twisted phonon polaritonic slabs"},{"main_file_link":[{"url":"https://arxiv.org/abs/1702.07513","open_access":"1"}],"title":"Waist of balls in hyperbolic and spherical spaces","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","type":"journal_article","publication":"International Mathematics Research Notices","abstract":[{"text":"In this paper we find a tight estimate for Gromov’s waist of the balls in spaces of constant curvature, deduce the estimates for the balls in Riemannian manifolds with upper bounds on the curvature (CAT(ϰ)-spaces), and establish similar result for normed spaces.","lang":"eng"}],"doi":"10.1093/imrn/rny037","oa":1,"oa_version":"Preprint","status":"public","language":[{"iso":"eng"}],"article_processing_charge":"No","page":"669-697","quality_controlled":"1","publisher":"Oxford University Press","date_published":"2020-02-01T00:00:00Z","publication_identifier":{"eissn":["1687-0247"],"issn":["1073-7928"]},"publication_status":"published","year":"2020","arxiv":1,"intvolume":"      2020","day":"01","isi":1,"department":[{"_id":"HeEd"}],"month":"02","external_id":{"arxiv":["1702.07513"],"isi":["000522852700002"]},"scopus_import":"1","citation":{"ieee":"A. Akopyan and R. Karasev, “Waist of balls in hyperbolic and spherical spaces,” <i>International Mathematics Research Notices</i>, vol. 2020, no. 3. Oxford University Press, pp. 669–697, 2020.","apa":"Akopyan, A., &#38; Karasev, R. (2020). Waist of balls in hyperbolic and spherical spaces. <i>International Mathematics Research Notices</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/imrn/rny037\">https://doi.org/10.1093/imrn/rny037</a>","mla":"Akopyan, Arseniy, and Roman Karasev. “Waist of Balls in Hyperbolic and Spherical Spaces.” <i>International Mathematics Research Notices</i>, vol. 2020, no. 3, Oxford University Press, 2020, pp. 669–97, doi:<a href=\"https://doi.org/10.1093/imrn/rny037\">10.1093/imrn/rny037</a>.","short":"A. Akopyan, R. Karasev, International Mathematics Research Notices 2020 (2020) 669–697.","chicago":"Akopyan, Arseniy, and Roman Karasev. “Waist of Balls in Hyperbolic and Spherical Spaces.” <i>International Mathematics Research Notices</i>. Oxford University Press, 2020. <a href=\"https://doi.org/10.1093/imrn/rny037\">https://doi.org/10.1093/imrn/rny037</a>.","ista":"Akopyan A, Karasev R. 2020. Waist of balls in hyperbolic and spherical spaces. International Mathematics Research Notices. 2020(3), 669–697.","ama":"Akopyan A, Karasev R. Waist of balls in hyperbolic and spherical spaces. <i>International Mathematics Research Notices</i>. 2020;2020(3):669-697. doi:<a href=\"https://doi.org/10.1093/imrn/rny037\">10.1093/imrn/rny037</a>"},"volume":2020,"acknowledgement":" Supported by the Russian Foundation for Basic Research grant 18-01-00036.","issue":"3","date_created":"2022-03-18T11:39:30Z","_id":"10867","author":[{"first_name":"Arseniy","last_name":"Akopyan","id":"430D2C90-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2548-617X","full_name":"Akopyan, Arseniy"},{"last_name":"Karasev","first_name":"Roman","full_name":"Karasev, Roman"}],"keyword":["General Mathematics"],"article_type":"original","date_updated":"2023-08-24T14:19:55Z"},{"month":"06","pmid":1,"day":"17","intvolume":"       106","scopus_import":"1","citation":{"ieee":"U. H. Cho and M. Hetzer, “Nuclear periphery takes center stage: The role of nuclear pore complexes in cell identity and aging,” <i>Neuron</i>, vol. 106, no. 6. Elsevier, pp. 899–911, 2020.","mla":"Cho, Ukrae H., and Martin Hetzer. “Nuclear Periphery Takes Center Stage: The Role of Nuclear Pore Complexes in Cell Identity and Aging.” <i>Neuron</i>, vol. 106, no. 6, Elsevier, 2020, pp. 899–911, doi:<a href=\"https://doi.org/10.1016/j.neuron.2020.05.031\">10.1016/j.neuron.2020.05.031</a>.","apa":"Cho, U. H., &#38; Hetzer, M. (2020). Nuclear periphery takes center stage: The role of nuclear pore complexes in cell identity and aging. <i>Neuron</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.neuron.2020.05.031\">https://doi.org/10.1016/j.neuron.2020.05.031</a>","short":"U.H. Cho, M. Hetzer, Neuron 106 (2020) 899–911.","chicago":"Cho, Ukrae H., and Martin Hetzer. “Nuclear Periphery Takes Center Stage: The Role of Nuclear Pore Complexes in Cell Identity and Aging.” <i>Neuron</i>. Elsevier, 2020. <a href=\"https://doi.org/10.1016/j.neuron.2020.05.031\">https://doi.org/10.1016/j.neuron.2020.05.031</a>.","ista":"Cho UH, Hetzer M. 2020. Nuclear periphery takes center stage: The role of nuclear pore complexes in cell identity and aging. Neuron. 106(6), 899–911.","ama":"Cho UH, Hetzer M. Nuclear periphery takes center stage: The role of nuclear pore complexes in cell identity and aging. <i>Neuron</i>. 2020;106(6):899-911. doi:<a href=\"https://doi.org/10.1016/j.neuron.2020.05.031\">10.1016/j.neuron.2020.05.031</a>"},"external_id":{"pmid":["32553207"]},"_id":"11054","date_created":"2022-04-07T07:43:36Z","issue":"6","volume":106,"date_updated":"2022-07-18T08:29:35Z","keyword":["General Neuroscience"],"article_type":"review","author":[{"full_name":"Cho, Ukrae H.","first_name":"Ukrae H.","last_name":"Cho"},{"first_name":"Martin W","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","last_name":"HETZER","full_name":"HETZER, Martin W","orcid":"0000-0002-2111-992X"}],"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1016/j.neuron.2020.05.031"}],"user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","type":"journal_article","title":"Nuclear periphery takes center stage: The role of nuclear pore complexes in cell identity and aging","doi":"10.1016/j.neuron.2020.05.031","publication":"Neuron","abstract":[{"lang":"eng","text":"In recent years, the nuclear pore complex (NPC) has emerged as a key player in genome regulation and cellular homeostasis. New discoveries have revealed that the NPC has multiple cellular functions besides mediating the molecular exchange between the nucleus and the cytoplasm. In this review, we discuss non-transport aspects of the NPC focusing on the NPC-genome interaction, the extreme longevity of the NPC proteins, and NPC dysfunction in age-related diseases. The examples summarized herein demonstrate that the NPC, which first evolved to enable the biochemical communication between the nucleus and the cytoplasm, now doubles as the gatekeeper of cellular identity and aging."}],"language":[{"iso":"eng"}],"article_processing_charge":"No","oa":1,"status":"public","extern":"1","oa_version":"Published Version","date_published":"2020-06-17T00:00:00Z","year":"2020","publication_identifier":{"issn":["0896-6273"]},"publication_status":"published","page":"899-911","publisher":"Elsevier","quality_controlled":"1"},{"article_number":"e54383","language":[{"iso":"eng"}],"article_processing_charge":"No","oa":1,"has_accepted_license":"1","extern":"1","status":"public","oa_version":"Published Version","date_published":"2020-09-08T00:00:00Z","publication_status":"published","publication_identifier":{"issn":["2050-084X"]},"year":"2020","publisher":"eLife Sciences Publications","quality_controlled":"1","file":[{"file_size":4399825,"file_id":"11132","date_updated":"2022-04-08T06:53:10Z","file_name":"2020_eLife_Bersini.pdf","success":1,"access_level":"open_access","creator":"dernst","content_type":"application/pdf","checksum":"f8b3821349a194050be02570d8fe7d4b","date_created":"2022-04-08T06:53:10Z","relation":"main_file"}],"ddc":["570"],"type":"journal_article","user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","title":"Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome","doi":"10.7554/elife.54383","publication":"eLife","abstract":[{"text":"Vascular dysfunctions are a common feature of multiple age-related diseases. However, modeling healthy and pathological aging of the human vasculature represents an unresolved experimental challenge. Here, we generated induced vascular endothelial cells (iVECs) and smooth muscle cells (iSMCs) by direct reprogramming of healthy human fibroblasts from donors of different ages and Hutchinson-Gilford Progeria Syndrome (HGPS) patients. iVECs induced from old donors revealed upregulation of GSTM1 and PALD1, genes linked to oxidative stress, inflammation and endothelial junction stability, as vascular aging markers. A functional assay performed on PALD1 KD VECs demonstrated a recovery in vascular permeability. We found that iSMCs from HGPS donors overexpressed bone morphogenetic protein (BMP)−4, which plays a key role in both vascular calcification and endothelial barrier damage observed in HGPS. Strikingly, BMP4 concentrations are higher in serum from HGPS vs. age-matched mice. Furthermore, targeting BMP4 with blocking antibody recovered the functionality of the vascular barrier in vitro, hence representing a potential future therapeutic strategy to limit cardiovascular dysfunction in HGPS. These results show that iVECs and iSMCs retain disease-related signatures, allowing modeling of vascular aging and HGPS in vitro.","lang":"eng"}],"_id":"11055","date_created":"2022-04-07T07:43:48Z","file_date_updated":"2022-04-08T06:53:10Z","volume":9,"date_updated":"2022-07-18T08:30:37Z","tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"article_type":"original","keyword":["General Immunology and Microbiology","General Biochemistry","Genetics and Molecular Biology","General Medicine","General Neuroscience"],"author":[{"last_name":"Bersini","first_name":"Simone","full_name":"Bersini, Simone"},{"first_name":"Roberta","last_name":"Schulte","full_name":"Schulte, Roberta"},{"first_name":"Ling","last_name":"Huang","full_name":"Huang, Ling"},{"last_name":"Tsai","first_name":"Hannah","full_name":"Tsai, Hannah"},{"orcid":"0000-0002-2111-992X","full_name":"HETZER, Martin W","first_name":"Martin W","last_name":"HETZER","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed"}],"month":"09","pmid":1,"day":"08","intvolume":"         9","scopus_import":"1","citation":{"mla":"Bersini, Simone, et al. “Direct Reprogramming of Human Smooth Muscle and Vascular Endothelial Cells Reveals Defects Associated with Aging and Hutchinson-Gilford Progeria Syndrome.” <i>ELife</i>, vol. 9, e54383, eLife Sciences Publications, 2020, doi:<a href=\"https://doi.org/10.7554/elife.54383\">10.7554/elife.54383</a>.","short":"S. Bersini, R. Schulte, L. Huang, H. Tsai, M. Hetzer, ELife 9 (2020).","apa":"Bersini, S., Schulte, R., Huang, L., Tsai, H., &#38; Hetzer, M. (2020). Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome. <i>ELife</i>. eLife Sciences Publications. <a href=\"https://doi.org/10.7554/elife.54383\">https://doi.org/10.7554/elife.54383</a>","ama":"Bersini S, Schulte R, Huang L, Tsai H, Hetzer M. Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome. <i>eLife</i>. 2020;9. doi:<a href=\"https://doi.org/10.7554/elife.54383\">10.7554/elife.54383</a>","ista":"Bersini S, Schulte R, Huang L, Tsai H, Hetzer M. 2020. Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome. eLife. 9, e54383.","chicago":"Bersini, Simone, Roberta Schulte, Ling Huang, Hannah Tsai, and Martin Hetzer. “Direct Reprogramming of Human Smooth Muscle and Vascular Endothelial Cells Reveals Defects Associated with Aging and Hutchinson-Gilford Progeria Syndrome.” <i>ELife</i>. eLife Sciences Publications, 2020. <a href=\"https://doi.org/10.7554/elife.54383\">https://doi.org/10.7554/elife.54383</a>.","ieee":"S. Bersini, R. Schulte, L. Huang, H. Tsai, and M. Hetzer, “Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome,” <i>eLife</i>, vol. 9. eLife Sciences Publications, 2020."},"external_id":{"pmid":["32896271"]}},{"date_published":"2020-05-01T00:00:00Z","publication_identifier":{"issn":["2366-7478","2366-7478"]},"year":"2020","publication_status":"published","quality_controlled":"1","publisher":"Wiley","language":[{"iso":"eng"}],"article_number":"2000044","article_processing_charge":"No","has_accepted_license":"1","oa":1,"oa_version":"Published Version","extern":"1","status":"public","doi":"10.1002/adbi.202000044","publication":"Advanced Biosystems","abstract":[{"text":"Aging of the circulatory system correlates with the pathogenesis of a large spectrum of diseases. However, it is largely unknown which factors drive the age-dependent or pathological decline of the vasculature and how vascular defects relate to tissue aging. The goal of the study is to design a multianalytical approach to identify how the cellular microenvironment (i.e., fibroblasts) and serum from healthy donors of different ages or Alzheimer disease (AD) patients can modulate the functionality of organ-specific vascular endothelial cells (VECs). Long-living human microvascular networks embedding VECs and fibroblasts from skin biopsies are generated. RNA-seq, secretome analyses, and microfluidic assays demonstrate that fibroblasts from young donors restore the functionality of aged endothelial cells, an effect also achieved by serum from young donors. New biomarkers of vascular aging are validated in human biopsies and it is shown that young serum induces angiopoietin-like-4, which can restore compromised vascular barriers. This strategy is then employed to characterize transcriptional/functional changes induced on the blood–brain barrier by AD serum, demonstrating the importance of PTP4A3 in the regulation of permeability. Features of vascular degeneration during aging and AD are recapitulated, and a tool to identify novel biomarkers that can be exploited to develop future therapeutics modulating vascular function is established.","lang":"eng"}],"file":[{"file_size":2490829,"success":1,"file_name":"2020_AdvancedBiosystems_Bersini.pdf","date_updated":"2022-04-08T07:06:05Z","file_id":"11134","checksum":"5584d9a1609812dc75c02ce1e35d2ec0","content_type":"application/pdf","creator":"dernst","access_level":"open_access","date_created":"2022-04-08T07:06:05Z","relation":"main_file"}],"ddc":["570"],"title":"Transcriptional and functional changes of the human microvasculature during physiological aging and Alzheimer disease","user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","type":"journal_article","date_updated":"2022-07-18T08:30:48Z","tmp":{"short":"CC BY-NC-ND (4.0)","image":"/images/cc_by_nc_nd.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)"},"license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","author":[{"full_name":"Bersini, Simone","last_name":"Bersini","first_name":"Simone"},{"full_name":"Arrojo e Drigo, Rafael","first_name":"Rafael","last_name":"Arrojo e Drigo"},{"full_name":"Huang, Ling","last_name":"Huang","first_name":"Ling"},{"first_name":"Maxim N.","last_name":"Shokhirev","full_name":"Shokhirev, Maxim N."},{"last_name":"HETZER","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","first_name":"Martin W","orcid":"0000-0002-2111-992X","full_name":"HETZER, Martin W"}],"article_type":"original","keyword":["General Biochemistry","Genetics and Molecular Biology","Biomedical Engineering","Biomaterials"],"date_created":"2022-04-07T07:43:57Z","_id":"11056","volume":4,"issue":"5","file_date_updated":"2022-04-08T07:06:05Z","scopus_import":"1","citation":{"ieee":"S. Bersini, R. Arrojo e Drigo, L. Huang, M. N. Shokhirev, and M. Hetzer, “Transcriptional and functional changes of the human microvasculature during physiological aging and Alzheimer disease,” <i>Advanced Biosystems</i>, vol. 4, no. 5. Wiley, 2020.","short":"S. Bersini, R. Arrojo e Drigo, L. Huang, M.N. Shokhirev, M. Hetzer, Advanced Biosystems 4 (2020).","apa":"Bersini, S., Arrojo e Drigo, R., Huang, L., Shokhirev, M. N., &#38; Hetzer, M. (2020). Transcriptional and functional changes of the human microvasculature during physiological aging and Alzheimer disease. <i>Advanced Biosystems</i>. Wiley. <a href=\"https://doi.org/10.1002/adbi.202000044\">https://doi.org/10.1002/adbi.202000044</a>","mla":"Bersini, Simone, et al. “Transcriptional and Functional Changes of the Human Microvasculature during Physiological Aging and Alzheimer Disease.” <i>Advanced Biosystems</i>, vol. 4, no. 5, 2000044, Wiley, 2020, doi:<a href=\"https://doi.org/10.1002/adbi.202000044\">10.1002/adbi.202000044</a>.","chicago":"Bersini, Simone, Rafael Arrojo e Drigo, Ling Huang, Maxim N. Shokhirev, and Martin Hetzer. “Transcriptional and Functional Changes of the Human Microvasculature during Physiological Aging and Alzheimer Disease.” <i>Advanced Biosystems</i>. Wiley, 2020. <a href=\"https://doi.org/10.1002/adbi.202000044\">https://doi.org/10.1002/adbi.202000044</a>.","ista":"Bersini S, Arrojo e Drigo R, Huang L, Shokhirev MN, Hetzer M. 2020. Transcriptional and functional changes of the human microvasculature during physiological aging and Alzheimer disease. Advanced Biosystems. 4(5), 2000044.","ama":"Bersini S, Arrojo e Drigo R, Huang L, Shokhirev MN, Hetzer M. Transcriptional and functional changes of the human microvasculature during physiological aging and Alzheimer disease. <i>Advanced Biosystems</i>. 2020;4(5). doi:<a href=\"https://doi.org/10.1002/adbi.202000044\">10.1002/adbi.202000044</a>"},"external_id":{"pmid":["32402127"]},"pmid":1,"month":"05","intvolume":"         4","day":"01"},{"month":"04","pmid":1,"day":"28","intvolume":"        34","citation":{"ama":"Kang H, Shokhirev MN, Xu Z, Chandran S, Dixon JR, Hetzer M. Dynamic regulation of histone modifications and long-range chromosomal interactions during postmitotic transcriptional reactivation. <i>Genes &#38; Development</i>. 2020;34(13-14):913-930. doi:<a href=\"https://doi.org/10.1101/gad.335794.119\">10.1101/gad.335794.119</a>","ista":"Kang H, Shokhirev MN, Xu Z, Chandran S, Dixon JR, Hetzer M. 2020. Dynamic regulation of histone modifications and long-range chromosomal interactions during postmitotic transcriptional reactivation. Genes &#38; Development. 34(13–14), 913–930.","chicago":"Kang, Hyeseon, Maxim N. Shokhirev, Zhichao Xu, Sahaana Chandran, Jesse R. Dixon, and Martin Hetzer. “Dynamic Regulation of Histone Modifications and Long-Range Chromosomal Interactions during Postmitotic Transcriptional Reactivation.” <i>Genes &#38; Development</i>. Cold Spring Harbor Laboratory Press, 2020. <a href=\"https://doi.org/10.1101/gad.335794.119\">https://doi.org/10.1101/gad.335794.119</a>.","apa":"Kang, H., Shokhirev, M. N., Xu, Z., Chandran, S., Dixon, J. R., &#38; Hetzer, M. (2020). Dynamic regulation of histone modifications and long-range chromosomal interactions during postmitotic transcriptional reactivation. <i>Genes &#38; Development</i>. Cold Spring Harbor Laboratory Press. <a href=\"https://doi.org/10.1101/gad.335794.119\">https://doi.org/10.1101/gad.335794.119</a>","mla":"Kang, Hyeseon, et al. “Dynamic Regulation of Histone Modifications and Long-Range Chromosomal Interactions during Postmitotic Transcriptional Reactivation.” <i>Genes &#38; Development</i>, vol. 34, no. 13–14, Cold Spring Harbor Laboratory Press, 2020, pp. 913–30, doi:<a href=\"https://doi.org/10.1101/gad.335794.119\">10.1101/gad.335794.119</a>.","short":"H. Kang, M.N. Shokhirev, Z. Xu, S. Chandran, J.R. Dixon, M. Hetzer, Genes &#38; Development 34 (2020) 913–930.","ieee":"H. Kang, M. N. Shokhirev, Z. Xu, S. Chandran, J. R. Dixon, and M. Hetzer, “Dynamic regulation of histone modifications and long-range chromosomal interactions during postmitotic transcriptional reactivation,” <i>Genes &#38; Development</i>, vol. 34, no. 13–14. Cold Spring Harbor Laboratory Press, pp. 913–930, 2020."},"scopus_import":"1","external_id":{"pmid":["32499403"]},"_id":"11057","date_created":"2022-04-07T07:44:09Z","issue":"13-14","file_date_updated":"2022-04-08T07:12:33Z","volume":34,"tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"date_updated":"2022-07-18T08:31:08Z","keyword":["Developmental Biology","Genetics"],"author":[{"first_name":"Hyeseon","last_name":"Kang","full_name":"Kang, Hyeseon"},{"first_name":"Maxim N.","last_name":"Shokhirev","full_name":"Shokhirev, Maxim N."},{"last_name":"Xu","first_name":"Zhichao","full_name":"Xu, Zhichao"},{"full_name":"Chandran, Sahaana","last_name":"Chandran","first_name":"Sahaana"},{"last_name":"Dixon","first_name":"Jesse R.","full_name":"Dixon, Jesse R."},{"orcid":"0000-0002-2111-992X","full_name":"HETZER, Martin W","last_name":"HETZER","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","first_name":"Martin W"}],"article_type":"original","file":[{"file_size":4406772,"file_id":"11136","file_name":"2020_GenesDevelopment_Kang.pdf","success":1,"date_updated":"2022-04-08T07:12:33Z","access_level":"open_access","creator":"dernst","content_type":"application/pdf","checksum":"84e92d40e67936c739628315c238daf9","date_created":"2022-04-08T07:12:33Z","relation":"main_file"}],"ddc":["570"],"user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","type":"journal_article","title":"Dynamic regulation of histone modifications and long-range chromosomal interactions during postmitotic transcriptional reactivation","doi":"10.1101/gad.335794.119","abstract":[{"text":"During mitosis, transcription of genomic DNA is dramatically reduced, before it is reactivated during nuclear reformation in anaphase/telophase. Many aspects of the underlying principles that mediate transcriptional memory and reactivation in the daughter cells remain unclear. Here, we used ChIP-seq on synchronized cells at different stages after mitosis to generate genome-wide maps of histone modifications. Combined with EU-RNA-seq and Hi-C analyses, we found that during prometaphase, promoters, enhancers, and insulators retain H3K4me3 and H3K4me1, while losing H3K27ac. Enhancers globally retaining mitotic H3K4me1 or locally retaining mitotic H3K27ac are associated with cell type-specific genes and their transcription factors for rapid transcriptional activation. As cells exit mitosis, promoters regain H3K27ac, which correlates with transcriptional reactivation. Insulators also gain H3K27ac and CCCTC-binding factor (CTCF) in anaphase/telophase. This increase of H3K27ac in anaphase/telophase is required for posttranscriptional activation and may play a role in the establishment of topologically associating domains (TADs). Together, our results suggest that the genome is reorganized in a sequential order, in which histone methylations occur first in prometaphase, histone acetylation, and CTCF in anaphase/telophase, transcription in cytokinesis, and long-range chromatin interactions in early G1. We thus provide insights into the histone modification landscape that allows faithful reestablishment of the transcriptional program and TADs during cell division.","lang":"eng"}],"publication":"Genes & Development","article_processing_charge":"No","language":[{"iso":"eng"}],"status":"public","extern":"1","oa_version":"Published Version","oa":1,"has_accepted_license":"1","publication_status":"published","publication_identifier":{"issn":["0890-9369","1549-5477"]},"year":"2020","date_published":"2020-04-28T00:00:00Z","publisher":"Cold Spring Harbor Laboratory Press","quality_controlled":"1","page":"913-930"},{"external_id":{"pmid":["31959624"]},"citation":{"ieee":"S. Bersini, N. K. Lytle, R. Schulte, L. Huang, G. M. Wahl, and M. Hetzer, “Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling,” <i>Life Science Alliance</i>, vol. 3, no. 1. Life Science Alliance, 2020.","short":"S. Bersini, N.K. Lytle, R. Schulte, L. Huang, G.M. Wahl, M. Hetzer, Life Science Alliance 3 (2020).","apa":"Bersini, S., Lytle, N. K., Schulte, R., Huang, L., Wahl, G. M., &#38; Hetzer, M. (2020). Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling. <i>Life Science Alliance</i>. Life Science Alliance. <a href=\"https://doi.org/10.26508/lsa.201900623\">https://doi.org/10.26508/lsa.201900623</a>","mla":"Bersini, Simone, et al. “Nup93 Regulates Breast Tumor Growth by Modulating Cell Proliferation and Actin Cytoskeleton Remodeling.” <i>Life Science Alliance</i>, vol. 3, no. 1, e201900623, Life Science Alliance, 2020, doi:<a href=\"https://doi.org/10.26508/lsa.201900623\">10.26508/lsa.201900623</a>.","ama":"Bersini S, Lytle NK, Schulte R, Huang L, Wahl GM, Hetzer M. Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling. <i>Life Science Alliance</i>. 2020;3(1). doi:<a href=\"https://doi.org/10.26508/lsa.201900623\">10.26508/lsa.201900623</a>","ista":"Bersini S, Lytle NK, Schulte R, Huang L, Wahl GM, Hetzer M. 2020. Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling. Life Science Alliance. 3(1), e201900623.","chicago":"Bersini, Simone, Nikki K Lytle, Roberta Schulte, Ling Huang, Geoffrey M Wahl, and Martin Hetzer. “Nup93 Regulates Breast Tumor Growth by Modulating Cell Proliferation and Actin Cytoskeleton Remodeling.” <i>Life Science Alliance</i>. Life Science Alliance, 2020. <a href=\"https://doi.org/10.26508/lsa.201900623\">https://doi.org/10.26508/lsa.201900623</a>."},"scopus_import":"1","day":"01","intvolume":"         3","month":"01","pmid":1,"keyword":["Health","Toxicology and Mutagenesis","Plant Science","Biochemistry","Genetics and Molecular Biology (miscellaneous)","Ecology"],"author":[{"full_name":"Bersini, Simone","first_name":"Simone","last_name":"Bersini"},{"full_name":"Lytle, Nikki K","first_name":"Nikki K","last_name":"Lytle"},{"full_name":"Schulte, Roberta","first_name":"Roberta","last_name":"Schulte"},{"full_name":"Huang, Ling","first_name":"Ling","last_name":"Huang"},{"full_name":"Wahl, Geoffrey M","first_name":"Geoffrey M","last_name":"Wahl"},{"first_name":"Martin W","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","last_name":"HETZER","full_name":"HETZER, Martin W","orcid":"0000-0002-2111-992X"}],"article_type":"original","date_updated":"2022-07-18T08:31:20Z","tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"issue":"1","file_date_updated":"2022-04-08T07:33:01Z","volume":3,"_id":"11058","date_created":"2022-04-07T07:44:18Z","abstract":[{"lang":"eng","text":"Nucleoporin 93 (Nup93) expression inversely correlates with the survival of triple-negative breast cancer patients. However, our knowledge of Nup93 function in breast cancer besides its role as structural component of the nuclear pore complex is not understood. Combination of functional assays and genetic analyses suggested that chromatin interaction of Nup93 partially modulates the expression of genes associated with actin cytoskeleton remodeling and epithelial to mesenchymal transition, resulting in impaired invasion of triple-negative, claudin-low breast cancer cells. Nup93 depletion induced stress fiber formation associated with reduced cell migration/proliferation and impaired expression of mesenchymal-like genes. Silencing LIMCH1, a gene responsible for actin cytoskeleton remodeling and up-regulated upon Nup93 depletion, partially restored the invasive phenotype of cancer cells. Loss of Nup93 led to significant defects in tumor establishment/propagation in vivo, whereas patient samples revealed that high Nup93 and low LIMCH1 expression correlate with late tumor stage. Our approach identified Nup93 as contributor of triple-negative, claudin-low breast cancer cell invasion and paves the way to study the role of nuclear envelope proteins during breast cancer tumorigenesis."}],"publication":"Life Science Alliance","doi":"10.26508/lsa.201900623","user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","type":"journal_article","title":"Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling","file":[{"checksum":"3bf33e7e93bef7823287807206b69b38","creator":"dernst","content_type":"application/pdf","access_level":"open_access","date_created":"2022-04-08T07:33:01Z","relation":"main_file","file_size":2653960,"success":1,"file_name":"2020_LifeScienceAlliance_Bersini.pdf","date_updated":"2022-04-08T07:33:01Z","file_id":"11137"}],"ddc":["570"],"publisher":"Life Science Alliance","quality_controlled":"1","publication_identifier":{"issn":["2575-1077"]},"publication_status":"published","year":"2020","date_published":"2020-01-01T00:00:00Z","extern":"1","status":"public","oa_version":"Published Version","oa":1,"has_accepted_license":"1","article_processing_charge":"No","article_number":"e201900623","language":[{"iso":"eng"}]},{"oa_version":"Published Version","status":"public","extern":"1","oa":1,"article_processing_charge":"No","language":[{"iso":"eng"}],"article_number":"A118","quality_controlled":"1","publisher":"EDP Sciences","year":"2020","publication_status":"published","publication_identifier":{"issn":["0004-6361"],"eissn":["1432-0746"]},"date_published":"2020-09-18T00:00:00Z","title":"The MUSE Hubble Ultra Deep Field Survey: XV. The mean rest-UV spectra of Lyα emitters at z > 3","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"journal_article","main_file_link":[{"url":"https://arxiv.org/abs/2007.01878","open_access":"1"}],"abstract":[{"lang":"eng","text":"We investigated the ultraviolet (UV) spectral properties of faint Lyman-α emitters (LAEs) in the redshift range 2.9 ≤ z ≤ 4.6, and we provide material to prepare future observations of the faint Universe. We used data from the MUSE Hubble Ultra Deep Survey to construct mean rest-frame spectra of continuum-faint (median MUV of −18 and down to MUV of −16), low stellar mass (median value of 108.4 M⊙ and down to 107 M⊙) LAEs at redshift z ≳ 3. We computed various averaged spectra of LAEs, subsampled on the basis of their observational (e.g., Lyα strength, UV magnitude and spectral slope) and physical (e.g., stellar mass and star-formation rate) properties. We searched for UV spectral features other than Lyα, such as higher ionization nebular emission lines and absorption features. We successfully observed the O III]λ1666 and [C III]λ1907+C III]λ1909 collisionally excited emission lines and the He IIλ1640 recombination feature, as well as the resonant C IVλλ1548,1551 doublet either in emission or P-Cygni. We compared the observed spectral properties of the different mean spectra and find the emission lines to vary with the observational and physical properties of the LAEs. In particular, the mean spectra of LAEs with larger Lyα equivalent widths, fainter UV magnitudes, bluer UV spectral slopes, and lower stellar masses show the strongest nebular emission. The line ratios of these lines are similar to those measured in the spectra of local metal-poor galaxies, while their equivalent widths are weaker compared to the handful of extreme values detected in individual spectra of z >  2 galaxies. This suggests that weak UV features are likely ubiquitous in high z, low-mass, and faint LAEs. We publicly released the stacked spectra, as they can serve as empirical templates for the design of future observations, such as those with the James Webb Space Telescope and the Extremely Large Telescope."}],"publication":"Astronomy & Astrophysics","doi":"10.1051/0004-6361/202038133","volume":641,"acknowledgement":"We thank Margherita Talia, Stéphane Charlot, Adele Plat and Alba Vidal-García for helpful discussions. This work is supported by the ERC advanced grant 339659-MUSICOS (R. Bacon). AF acknowledges the support from grant PRIN MIUR 2017 20173ML3WW. MVM and JP would like to thank the Leiden/ESA Astrophysics Program for Summer Students (LEAPS) for funding at the outset of this project. FL, HK, and AV acknowledge support from the ERC starting grant ERC-757258-TRIPLE. TH was supported by Leading Initiative for Excellent Young Researchers, MEXT, Japan. JB acknowledges support by FCT/MCTES through national funds by the grant UID/FIS/04434/2019, UIDB/04434/2020 and UIDP/04434/2020 and through the Investigador FCT Contract No. IF/01654/2014/CP1215/CT0003. HI acknowledges support from JSPS KAKENHI Grant Number JP19K23462. We would also like to thank the organizers and participants of the Leiden Lorentz Center workshop: Revolutionary Spectroscopy of Today as a Springboard to Webb. This work made use of several open source python packages: NUMPY (van der Walt et al. 2011), MATPLOTLIB (Hunter 2007), ASTROPY (Astropy Collaboration 2013) and MPDAF (MUSE Python Data Analysis Framework, Piqueras et al. 2019).","date_created":"2022-07-06T09:38:16Z","_id":"11501","author":[{"first_name":"Anna","last_name":"Feltre","full_name":"Feltre, Anna"},{"first_name":"Michael V.","last_name":"Maseda","full_name":"Maseda, Michael V."},{"first_name":"Roland","last_name":"Bacon","full_name":"Bacon, Roland"},{"last_name":"Pradeep","first_name":"Jayadev","full_name":"Pradeep, Jayadev"},{"last_name":"Leclercq","first_name":"Floriane","full_name":"Leclercq, Floriane"},{"last_name":"Kusakabe","first_name":"Haruka","full_name":"Kusakabe, Haruka"},{"full_name":"Wisotzki, Lutz","last_name":"Wisotzki","first_name":"Lutz"},{"full_name":"Hashimoto, Takuya","last_name":"Hashimoto","first_name":"Takuya"},{"full_name":"Schmidt, Kasper B.","first_name":"Kasper B.","last_name":"Schmidt"},{"last_name":"Blaizot","first_name":"Jeremy","full_name":"Blaizot, Jeremy"},{"first_name":"Jarle","last_name":"Brinchmann","full_name":"Brinchmann, Jarle"},{"first_name":"Leindert","last_name":"Boogaard","full_name":"Boogaard, Leindert"},{"first_name":"Sebastiano","last_name":"Cantalupo","full_name":"Cantalupo, Sebastiano"},{"first_name":"David","last_name":"Carton","full_name":"Carton, David"},{"first_name":"Hanae","last_name":"Inami","full_name":"Inami, Hanae"},{"last_name":"Kollatschny","first_name":"Wolfram","full_name":"Kollatschny, Wolfram"},{"full_name":"Marino, Raffaella A.","last_name":"Marino","first_name":"Raffaella A."},{"orcid":"0000-0003-2871-127X","full_name":"Matthee, Jorryt J","first_name":"Jorryt J","last_name":"Matthee","id":"7439a258-f3c0-11ec-9501-9df22fe06720"},{"full_name":"Nanayakkara, Themiya","first_name":"Themiya","last_name":"Nanayakkara"},{"full_name":"Richard, Johan","last_name":"Richard","first_name":"Johan"},{"full_name":"Schaye, Joop","last_name":"Schaye","first_name":"Joop"},{"first_name":"Laurence","last_name":"Tresse","full_name":"Tresse, Laurence"},{"full_name":"Urrutia, Tanya","first_name":"Tanya","last_name":"Urrutia"},{"full_name":"Verhamme, Anne","last_name":"Verhamme","first_name":"Anne"},{"last_name":"Weilbacher","first_name":"Peter M.","full_name":"Weilbacher, Peter M."}],"article_type":"original","keyword":["Space and Planetary Science","Astronomy and Astrophysics","galaxies: evolution / galaxies: high-redshift / ISM: lines and bands / ultraviolet: ISM / ultraviolet: galaxies"],"date_updated":"2022-07-19T09:35:43Z","intvolume":"       641","day":"18","arxiv":1,"month":"09","external_id":{"arxiv":["2007.01878"]},"citation":{"ieee":"A. Feltre <i>et al.</i>, “The MUSE Hubble Ultra Deep Field Survey: XV. The mean rest-UV spectra of Lyα emitters at z &#62; 3,” <i>Astronomy &#38; Astrophysics</i>, vol. 641. EDP Sciences, 2020.","apa":"Feltre, A., Maseda, M. V., Bacon, R., Pradeep, J., Leclercq, F., Kusakabe, H., … Weilbacher, P. M. (2020). The MUSE Hubble Ultra Deep Field Survey: XV. The mean rest-UV spectra of Lyα emitters at z &#62; 3. <i>Astronomy &#38; Astrophysics</i>. EDP Sciences. <a href=\"https://doi.org/10.1051/0004-6361/202038133\">https://doi.org/10.1051/0004-6361/202038133</a>","mla":"Feltre, Anna, et al. “The MUSE Hubble Ultra Deep Field Survey: XV. The Mean Rest-UV Spectra of Lyα Emitters at z &#62; 3.” <i>Astronomy &#38; Astrophysics</i>, vol. 641, A118, EDP Sciences, 2020, doi:<a href=\"https://doi.org/10.1051/0004-6361/202038133\">10.1051/0004-6361/202038133</a>.","short":"A. Feltre, M.V. Maseda, R. Bacon, J. Pradeep, F. Leclercq, H. Kusakabe, L. Wisotzki, T. Hashimoto, K.B. Schmidt, J. Blaizot, J. Brinchmann, L. Boogaard, S. Cantalupo, D. Carton, H. Inami, W. Kollatschny, R.A. Marino, J.J. Matthee, T. Nanayakkara, J. Richard, J. Schaye, L. Tresse, T. Urrutia, A. Verhamme, P.M. Weilbacher, Astronomy &#38; Astrophysics 641 (2020).","chicago":"Feltre, Anna, Michael V. Maseda, Roland Bacon, Jayadev Pradeep, Floriane Leclercq, Haruka Kusakabe, Lutz Wisotzki, et al. “The MUSE Hubble Ultra Deep Field Survey: XV. The Mean Rest-UV Spectra of Lyα Emitters at z &#62; 3.” <i>Astronomy &#38; Astrophysics</i>. EDP Sciences, 2020. <a href=\"https://doi.org/10.1051/0004-6361/202038133\">https://doi.org/10.1051/0004-6361/202038133</a>.","ista":"Feltre A, Maseda MV, Bacon R, Pradeep J, Leclercq F, Kusakabe H, Wisotzki L, Hashimoto T, Schmidt KB, Blaizot J, Brinchmann J, Boogaard L, Cantalupo S, Carton D, Inami H, Kollatschny W, Marino RA, Matthee JJ, Nanayakkara T, Richard J, Schaye J, Tresse L, Urrutia T, Verhamme A, Weilbacher PM. 2020. The MUSE Hubble Ultra Deep Field Survey: XV. The mean rest-UV spectra of Lyα emitters at z &#62; 3. Astronomy &#38; Astrophysics. 641, A118.","ama":"Feltre A, Maseda MV, Bacon R, et al. The MUSE Hubble Ultra Deep Field Survey: XV. The mean rest-UV spectra of Lyα emitters at z &#62; 3. <i>Astronomy &#38; Astrophysics</i>. 2020;641. doi:<a href=\"https://doi.org/10.1051/0004-6361/202038133\">10.1051/0004-6361/202038133</a>"},"scopus_import":"1"}]