[{"acknowledgement":"We thank anonymous reviewers for valuable inputs. This work is supported in part by NSF grant 2030859 to the CRA for the CIFellows Project, NSF grants IIS-1527668, CCF-1704883, IIS-1830549, the ERC CoG 863818 (ForM-SMArt), and an award from the Maryland Procurement Office.","project":[{"name":"Formal Methods for Stochastic Models: Algorithms and Applications","grant_number":"863818","call_identifier":"H2020","_id":"0599E47C-7A3F-11EA-A408-12923DDC885E"}],"doi":"10.1007/978-3-030-72016-2","ddc":["000"],"language":[{"iso":"eng"}],"conference":{"start_date":"2021-03-27","end_date":"2021-04-01","name":"TACAS: Tools and Algorithms for the Construction and Analysis of Systems","location":"Luxembourg City, Luxembourg"},"title":"On satisficing in quantitative games","ec_funded":1,"citation":{"apa":"Bansal, S., Chatterjee, K., &#38; Vardi, M. Y. (2021). On satisficing in quantitative games. In <i>27th International Conference on Tools and Algorithms for the Construction and Analysis of Systems</i> (Vol. 12651, pp. 20–37). Luxembourg City, Luxembourg: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-030-72016-2\">https://doi.org/10.1007/978-3-030-72016-2</a>","ama":"Bansal S, Chatterjee K, Vardi MY. On satisficing in quantitative games. In: <i>27th International Conference on Tools and Algorithms for the Construction and Analysis of Systems</i>. Vol 12651. Springer Nature; 2021:20-37. doi:<a href=\"https://doi.org/10.1007/978-3-030-72016-2\">10.1007/978-3-030-72016-2</a>","short":"S. Bansal, K. Chatterjee, M.Y. Vardi, in:, 27th International Conference on Tools and Algorithms for the Construction and Analysis of Systems, Springer Nature, 2021, pp. 20–37.","mla":"Bansal, Suguman, et al. “On Satisficing in Quantitative Games.” <i>27th International Conference on Tools and Algorithms for the Construction and Analysis of Systems</i>, vol. 12651, Springer Nature, 2021, pp. 20–37, doi:<a href=\"https://doi.org/10.1007/978-3-030-72016-2\">10.1007/978-3-030-72016-2</a>.","ieee":"S. Bansal, K. Chatterjee, and M. Y. Vardi, “On satisficing in quantitative games,” in <i>27th International Conference on Tools and Algorithms for the Construction and Analysis of Systems</i>, Luxembourg City, Luxembourg, 2021, vol. 12651, pp. 20–37.","ista":"Bansal S, Chatterjee K, Vardi MY. 2021. On satisficing in quantitative games. 27th International Conference on Tools and Algorithms for the Construction and Analysis of Systems. TACAS: Tools and Algorithms for the Construction and Analysis of Systems, LNCS, vol. 12651, 20–37.","chicago":"Bansal, Suguman, Krishnendu Chatterjee, and Moshe Y. Vardi. “On Satisficing in Quantitative Games.” In <i>27th International Conference on Tools and Algorithms for the Construction and Analysis of Systems</i>, 12651:20–37. Springer Nature, 2021. <a href=\"https://doi.org/10.1007/978-3-030-72016-2\">https://doi.org/10.1007/978-3-030-72016-2</a>."},"alternative_title":["LNCS"],"author":[{"full_name":"Bansal, Suguman","first_name":"Suguman","last_name":"Bansal"},{"last_name":"Chatterjee","full_name":"Chatterjee, Krishnendu","first_name":"Krishnendu","orcid":"0000-0002-4561-241X","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Vardi","full_name":"Vardi, Moshe Y.","first_name":"Moshe Y."}],"type":"conference","day":"21","publisher":"Springer Nature","intvolume":"     12651","status":"public","department":[{"_id":"KrCh"}],"quality_controlled":"1","publication":"27th International Conference on Tools and Algorithms for the Construction and Analysis of Systems","page":"20-37","date_created":"2023-03-26T22:01:09Z","month":"03","publication_identifier":{"isbn":["9783030720155"],"issn":["0302-9743"],"eissn":["1611-3349"]},"date_updated":"2025-07-14T09:09:51Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","external_id":{"arxiv":["2101.02594"]},"scopus_import":"1","year":"2021","has_accepted_license":"1","oa_version":"Published Version","oa":1,"publication_status":"published","volume":12651,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"file_date_updated":"2023-03-28T11:00:33Z","article_processing_charge":"No","arxiv":1,"date_published":"2021-03-21T00:00:00Z","_id":"12767","abstract":[{"lang":"eng","text":"Several problems in planning and reactive synthesis can be reduced to the analysis of two-player quantitative graph games. Optimization is one form of analysis. We argue that in many cases it may be better to replace the optimization problem with the satisficing problem, where instead of searching for optimal solutions, the goal is to search for solutions that adhere to a given threshold bound.\r\nThis work defines and investigates the satisficing problem on a two-player graph game with the discounted-sum cost model. We show that while the satisficing problem can be solved using numerical methods just like the optimization problem, this approach does not render compelling benefits over optimization. When the discount factor is, however, an integer, we present another approach to satisficing, which is purely based on automata methods. We show that this approach is algorithmically more performant – both theoretically and empirically – and demonstrates the broader applicability of satisficing over optimization."}],"file":[{"checksum":"b020b78b23587ce7610b1aafb4e63438","date_updated":"2023-03-28T11:00:33Z","access_level":"open_access","file_name":"2021_LNCS_Bansal.pdf","creator":"dernst","file_size":747418,"date_created":"2023-03-28T11:00:33Z","success":1,"content_type":"application/pdf","relation":"main_file","file_id":"12777"}]},{"citation":{"ieee":"A. Schlögl, S. Elefante, A. Hornoiu, and S. Stadlbauer, “Managing software on a heterogenous HPC cluster,” in <i>ASHPC21 – Austrian-Slovenian HPC Meeting 2021</i>, Virtual, 2021, p. 5.","ista":"Schlögl A, Elefante S, Hornoiu A, Stadlbauer S. 2021. Managing software on a heterogenous HPC cluster. ASHPC21 – Austrian-Slovenian HPC Meeting 2021. ASHPC - Austrian-Slovenian HPC Meeting, 5.","chicago":"Schlögl, Alois, Stefano Elefante, Andrei Hornoiu, and Stephan Stadlbauer. “Managing Software on a Heterogenous HPC Cluster.” In <i>ASHPC21 – Austrian-Slovenian HPC Meeting 2021</i>, 5. University of Ljubljana, 2021. <a href=\"https://doi.org/10.3359/2021hpc\">https://doi.org/10.3359/2021hpc</a>.","mla":"Schlögl, Alois, et al. “Managing Software on a Heterogenous HPC Cluster.” <i>ASHPC21 – Austrian-Slovenian HPC Meeting 2021</i>, University of Ljubljana, 2021, p. 5, doi:<a href=\"https://doi.org/10.3359/2021hpc\">10.3359/2021hpc</a>.","short":"A. Schlögl, S. Elefante, A. Hornoiu, S. Stadlbauer, in:, ASHPC21 – Austrian-Slovenian HPC Meeting 2021, University of Ljubljana, 2021, p. 5.","apa":"Schlögl, A., Elefante, S., Hornoiu, A., &#38; Stadlbauer, S. (2021). Managing software on a heterogenous HPC cluster. In <i>ASHPC21 – Austrian-Slovenian HPC Meeting 2021</i> (p. 5). Virtual: University of Ljubljana. <a href=\"https://doi.org/10.3359/2021hpc\">https://doi.org/10.3359/2021hpc</a>","ama":"Schlögl A, Elefante S, Hornoiu A, Stadlbauer S. Managing software on a heterogenous HPC cluster. In: <i>ASHPC21 – Austrian-Slovenian HPC Meeting 2021</i>. University of Ljubljana; 2021:5. doi:<a href=\"https://doi.org/10.3359/2021hpc\">10.3359/2021hpc</a>"},"title":"Managing software on a heterogenous HPC cluster","conference":{"location":"Virtual","start_date":"2021-05-31","end_date":"2021-06-02","name":"ASHPC - Austrian-Slovenian HPC Meeting"},"day":"02","author":[{"last_name":"Schlögl","first_name":"Alois","full_name":"Schlögl, Alois","id":"45BF87EE-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-5621-8100"},{"first_name":"Stefano","full_name":"Elefante, Stefano","last_name":"Elefante","id":"490F40CE-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Hornoiu","full_name":"Hornoiu, Andrei","first_name":"Andrei","id":"77129392-B450-11EA-8745-D4653DDC885E"},{"id":"4D0BC184-F248-11E8-B48F-1D18A9856A87","full_name":"Stadlbauer, Stephan","first_name":"Stephan","last_name":"Stadlbauer"}],"type":"conference_abstract","has_accepted_license":"1","year":"2021","oa_version":"Published Version","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","language":[{"iso":"eng"}],"date_updated":"2023-05-16T07:43:54Z","publication_identifier":{"isbn":["978-961-6980-77-7","978-961-6133-48-7"]},"ddc":["000"],"doi":"10.3359/2021hpc","page":"5","article_processing_charge":"No","month":"06","file":[{"checksum":"ba73f85858fb9d5737ebc7724646dd45","access_level":"open_access","date_updated":"2023-05-16T07:36:34Z","creator":"dernst","file_size":422761,"file_name":"2021_ASHPC_Schloegl.pdf","date_created":"2023-05-16T07:36:34Z","success":1,"file_id":"12971","relation":"main_file","content_type":"application/pdf"}],"_id":"12909","date_created":"2023-05-05T13:17:36Z","date_published":"2021-06-02T00:00:00Z","publication_status":"published","publisher":"University of Ljubljana","main_file_link":[{"open_access":"1","url":"https://vsc.ac.at/fileadmin/user_upload/vsc/conferences/ashpc21/BOOKLET_ASHPC21.pdf"}],"oa":1,"publication":"ASHPC21 – Austrian-Slovenian HPC Meeting 2021","department":[{"_id":"ScienComp"}],"file_date_updated":"2023-05-16T07:36:34Z","status":"public"},{"article_processing_charge":"No","month":"04","date_created":"2023-05-16T12:34:09Z","_id":"12987","date_published":"2021-04-10T00:00:00Z","abstract":[{"text":"Chromosomal inversion polymorphisms, segments of chromosomes that are flipped in orientation and occur in reversed order in some individuals, have long been recognized to play an important role in local adaptation. They can reduce recombination in heterozygous individuals and thus help to maintain sets of locally adapted alleles. In a wide range of organisms, populations adapted to different habitats differ in frequency of inversion arrangements. However, getting a full understanding of the importance of inversions for adaptation requires confirmation of their influence on traits under divergent selection. Here, we studied a marine snail, Littorina saxatilis, that has evolved ecotypes adapted to wave exposure or crab predation. These two types occur in close proximity on different parts of the shore. Gene flow between them exists in contact zones. However, they exhibit strong phenotypic divergence in several traits under habitat-specific selection, including size, shape and behaviour. We used crosses between these ecotypes to identify genomic regions that explain variation in these traits by using QTL analysis and variance partitioning across linkage groups. We could show that previously detected inversion regions contribute to adaptive divergence. Some inversions influenced multiple traits suggesting that they contain sets of locally adaptive alleles. Our study also identified regions without known inversions that are important for phenotypic divergence. Thus, we provide a more complete overview of the importance of inversions in relation to the remaining genome.","lang":"eng"}],"publisher":"Dryad","license":"https://creativecommons.org/publicdomain/zero/1.0/","oa":1,"main_file_link":[{"url":"https://doi.org/10.5061/dryad.zgmsbccb4","open_access":"1"}],"department":[{"_id":"NiBa"}],"status":"public","tmp":{"name":"Creative Commons Public Domain Dedication (CC0 1.0)","image":"/images/cc_0.png","legal_code_url":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","short":"CC0 (1.0)"},"citation":{"short":"E. Koch, H.E. Morales, J. Larsson, A.M. Westram, R. Faria, A.R. Lemmon, E.M. Lemmon, K. Johannesson, R.K. Butlin, (2021).","apa":"Koch, E., Morales, H. E., Larsson, J., Westram, A. M., Faria, R., Lemmon, A. R., … Butlin, R. K. (2021). Data from: Genetic variation for adaptive traits is associated with polymorphic inversions in Littorina saxatilis. Dryad. <a href=\"https://doi.org/10.5061/DRYAD.ZGMSBCCB4\">https://doi.org/10.5061/DRYAD.ZGMSBCCB4</a>","ama":"Koch E, Morales HE, Larsson J, et al. Data from: Genetic variation for adaptive traits is associated with polymorphic inversions in Littorina saxatilis. 2021. doi:<a href=\"https://doi.org/10.5061/DRYAD.ZGMSBCCB4\">10.5061/DRYAD.ZGMSBCCB4</a>","ista":"Koch E, Morales HE, Larsson J, Westram AM, Faria R, Lemmon AR, Lemmon EM, Johannesson K, Butlin RK. 2021. Data from: Genetic variation for adaptive traits is associated with polymorphic inversions in Littorina saxatilis, Dryad, <a href=\"https://doi.org/10.5061/DRYAD.ZGMSBCCB4\">10.5061/DRYAD.ZGMSBCCB4</a>.","ieee":"E. Koch <i>et al.</i>, “Data from: Genetic variation for adaptive traits is associated with polymorphic inversions in Littorina saxatilis.” Dryad, 2021.","chicago":"Koch, Eva, Hernán E. Morales, Jenny Larsson, Anja M Westram, Rui Faria, Alan R. Lemmon, E. Moriarty Lemmon, Kerstin Johannesson, and Roger K. Butlin. “Data from: Genetic Variation for Adaptive Traits Is Associated with Polymorphic Inversions in Littorina Saxatilis.” Dryad, 2021. <a href=\"https://doi.org/10.5061/DRYAD.ZGMSBCCB4\">https://doi.org/10.5061/DRYAD.ZGMSBCCB4</a>.","mla":"Koch, Eva, et al. <i>Data from: Genetic Variation for Adaptive Traits Is Associated with Polymorphic Inversions in Littorina Saxatilis</i>. Dryad, 2021, doi:<a href=\"https://doi.org/10.5061/DRYAD.ZGMSBCCB4\">10.5061/DRYAD.ZGMSBCCB4</a>."},"title":"Data from: Genetic variation for adaptive traits is associated with polymorphic inversions in Littorina saxatilis","day":"10","author":[{"first_name":"Eva","full_name":"Koch, Eva","last_name":"Koch"},{"full_name":"Morales, Hernán E.","first_name":"Hernán E.","last_name":"Morales"},{"first_name":"Jenny","full_name":"Larsson, Jenny","last_name":"Larsson"},{"id":"3C147470-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-1050-4969","last_name":"Westram","first_name":"Anja M","full_name":"Westram, Anja M"},{"first_name":"Rui","full_name":"Faria, Rui","last_name":"Faria"},{"last_name":"Lemmon","full_name":"Lemmon, Alan R.","first_name":"Alan R."},{"full_name":"Lemmon, E. Moriarty","first_name":"E. Moriarty","last_name":"Lemmon"},{"first_name":"Kerstin","full_name":"Johannesson, Kerstin","last_name":"Johannesson"},{"last_name":"Butlin","full_name":"Butlin, Roger K.","first_name":"Roger K."}],"type":"research_data_reference","has_accepted_license":"1","year":"2021","oa_version":"Published Version","related_material":{"record":[{"id":"9394","relation":"used_in_publication","status":"public"}]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2023-08-08T13:34:07Z","ddc":["570"],"doi":"10.5061/DRYAD.ZGMSBCCB4"},{"month":"04","extern":"1","article_number":"2104.15079","date_created":"2021-07-20T06:31:53Z","_id":"9695","abstract":[{"text":"Real-world data typically contain a large number of features that are often heterogeneous in nature, relevance, and also units of measure. When assessing the similarity between data points, one can build various distance measures using subsets of these features. Using the fewest features but still retaining sufficient information about the system is crucial in many statistical learning approaches, particularly when data are sparse. We introduce a statistical test that can assess the relative information retained when using two different distance measures, and determine if they are equivalent, independent, or if one is more informative than the other. This in turn allows finding the most informative distance measure out of a pool of candidates. The approach is applied to find the most relevant policy variables for controlling the Covid-19 epidemic and to find compact yet informative representations of atomic structures, but its potential applications are wide ranging in many branches of science.","lang":"eng"}],"date_published":"2021-04-30T00:00:00Z","arxiv":1,"article_processing_charge":"No","publication":"arXiv","status":"public","publication_status":"submitted","oa":1,"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/2104.15079"}],"day":"30","type":"preprint","author":[{"last_name":"Glielmo","first_name":"Aldo","full_name":"Glielmo, Aldo"},{"last_name":"Zeni","full_name":"Zeni, Claudio","first_name":"Claudio"},{"id":"cbe3cda4-d82c-11eb-8dc7-8ff94289fcc9","orcid":"0000-0002-3584-9632","first_name":"Bingqing","full_name":"Cheng, Bingqing","last_name":"Cheng"},{"last_name":"Csanyi","first_name":"Gabor","full_name":"Csanyi, Gabor"},{"first_name":"Alessandro","full_name":"Laio, Alessandro","last_name":"Laio"}],"oa_version":"Preprint","year":"2021","citation":{"mla":"Glielmo, Aldo, et al. “Ranking the Information Content of Distance Measures.” <i>ArXiv</i>, 2104.15079.","chicago":"Glielmo, Aldo, Claudio Zeni, Bingqing Cheng, Gabor Csanyi, and Alessandro Laio. “Ranking the Information Content of Distance Measures.” <i>ArXiv</i>, n.d.","ista":"Glielmo A, Zeni C, Cheng B, Csanyi G, Laio A. Ranking the information content of distance measures. arXiv, 2104.15079.","ieee":"A. Glielmo, C. Zeni, B. Cheng, G. Csanyi, and A. Laio, “Ranking the information content of distance measures,” <i>arXiv</i>. .","ama":"Glielmo A, Zeni C, Cheng B, Csanyi G, Laio A. Ranking the information content of distance measures. <i>arXiv</i>.","apa":"Glielmo, A., Zeni, C., Cheng, B., Csanyi, G., &#38; Laio, A. (n.d.). Ranking the information content of distance measures. <i>arXiv</i>.","short":"A. Glielmo, C. Zeni, B. Cheng, G. Csanyi, A. Laio, ArXiv (n.d.)."},"title":"Ranking the information content of distance measures","external_id":{"arxiv":["2104.15079"]},"user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","date_updated":"2023-02-23T14:05:13Z","language":[{"iso":"eng"}]},{"article_number":"2103.09035","extern":"1","month":"03","_id":"9696","date_created":"2021-07-20T06:42:29Z","abstract":[{"text":"Most water in the universe may be superionic, and its thermodynamic and transport properties are crucial for planetary science but difficult to probe experimentally or theoretically. We use machine learning and free energy methods to overcome the limitations of quantum mechanical simulations, and characterize hydrogen diffusion, superionic transitions, and phase behaviors of water at extreme conditions. We predict that a close-packed superionic phase with mixed stacking is stable over a wide temperature and pressure range, while a body-centered cubic phase is only thermodynamically stable in a small window but is kinetically favored. Our phase boundaries, which are consistent with the existing-albeit scarce-experimental observations, help resolve the fractions of insulating ice, different superionic phases, and liquid water inside of ice giants.","lang":"eng"}],"date_published":"2021-03-16T00:00:00Z","arxiv":1,"article_processing_charge":"No","publication":"arXiv","status":"public","publication_status":"submitted","oa":1,"main_file_link":[{"url":"https://arxiv.org/abs/2103.09035","open_access":"1"}],"day":"16","year":"2021","oa_version":"Preprint","type":"preprint","author":[{"last_name":"Cheng","first_name":"Bingqing","full_name":"Cheng, Bingqing","orcid":"0000-0002-3584-9632","id":"cbe3cda4-d82c-11eb-8dc7-8ff94289fcc9"},{"last_name":"Bethkenhagen","full_name":"Bethkenhagen, Mandy","first_name":"Mandy"},{"first_name":"Chris J.","full_name":"Pickard, Chris J.","last_name":"Pickard"},{"last_name":"Hamel","first_name":"Sebastien","full_name":"Hamel, Sebastien"}],"citation":{"short":"B. Cheng, M. Bethkenhagen, C.J. Pickard, S. Hamel, ArXiv (n.d.).","ama":"Cheng B, Bethkenhagen M, Pickard CJ, Hamel S. Predicting the phase behaviors of superionic water at planetary conditions. <i>arXiv</i>.","apa":"Cheng, B., Bethkenhagen, M., Pickard, C. J., &#38; Hamel, S. (n.d.). Predicting the phase behaviors of superionic water at planetary conditions. <i>arXiv</i>.","chicago":"Cheng, Bingqing, Mandy Bethkenhagen, Chris J. Pickard, and Sebastien Hamel. “Predicting the Phase Behaviors of Superionic Water at Planetary Conditions.” <i>ArXiv</i>, n.d.","ieee":"B. Cheng, M. Bethkenhagen, C. J. Pickard, and S. Hamel, “Predicting the phase behaviors of superionic water at planetary conditions,” <i>arXiv</i>. .","ista":"Cheng B, Bethkenhagen M, Pickard CJ, Hamel S. Predicting the phase behaviors of superionic water at planetary conditions. arXiv, 2103.09035.","mla":"Cheng, Bingqing, et al. “Predicting the Phase Behaviors of Superionic Water at Planetary Conditions.” <i>ArXiv</i>, 2103.09035."},"title":"Predicting the phase behaviors of superionic water at planetary conditions","user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","date_updated":"2023-02-23T14:05:16Z","language":[{"iso":"eng"}],"external_id":{"arxiv":["2103.09035"]}},{"publisher":"American Chemical Society","status":"public","intvolume":"       121","quality_controlled":"1","publication":"Chemical Reviews","page":"9816-9872","date_created":"2021-07-20T11:18:37Z","extern":"1","month":"07","doi":"10.1021/acs.chemrev.1c00107","language":[{"iso":"eng"}],"title":"Combining machine learning and computational chemistry for predictive insights into chemical systems","citation":{"apa":"Keith, J. A., Valentin Vassilev-Galindo, V., Cheng, B., Chmiela, S., Gastegger, M., Müller, K.-R., &#38; Tkatchenko, A. (2021). Combining machine learning and computational chemistry for predictive insights into chemical systems. <i>Chemical Reviews</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acs.chemrev.1c00107\">https://doi.org/10.1021/acs.chemrev.1c00107</a>","ama":"Keith JA, Valentin Vassilev-Galindo V, Cheng B, et al. Combining machine learning and computational chemistry for predictive insights into chemical systems. <i>Chemical Reviews</i>. 2021;121(16):9816-9872. doi:<a href=\"https://doi.org/10.1021/acs.chemrev.1c00107\">10.1021/acs.chemrev.1c00107</a>","short":"J.A. Keith, V. Valentin Vassilev-Galindo, B. Cheng, S. Chmiela, M. Gastegger, K.-R. Müller, A. Tkatchenko, Chemical Reviews 121 (2021) 9816–9872.","mla":"Keith, John A., et al. “Combining Machine Learning and Computational Chemistry for Predictive Insights into Chemical Systems.” <i>Chemical Reviews</i>, vol. 121, no. 16, American Chemical Society, 2021, pp. 9816–72, doi:<a href=\"https://doi.org/10.1021/acs.chemrev.1c00107\">10.1021/acs.chemrev.1c00107</a>.","ista":"Keith JA, Valentin Vassilev-Galindo V, Cheng B, Chmiela S, Gastegger M, Müller K-R, Tkatchenko A. 2021. Combining machine learning and computational chemistry for predictive insights into chemical systems. Chemical Reviews. 121(16), 9816–9872.","ieee":"J. A. Keith <i>et al.</i>, “Combining machine learning and computational chemistry for predictive insights into chemical systems,” <i>Chemical Reviews</i>, vol. 121, no. 16. American Chemical Society, pp. 9816–9872, 2021.","chicago":"Keith, John A., Valentin Valentin Vassilev-Galindo, Bingqing Cheng, Stefan Chmiela, Michael Gastegger, Klaus-Robert Müller, and Alexandre Tkatchenko. “Combining Machine Learning and Computational Chemistry for Predictive Insights into Chemical Systems.” <i>Chemical Reviews</i>. American Chemical Society, 2021. <a href=\"https://doi.org/10.1021/acs.chemrev.1c00107\">https://doi.org/10.1021/acs.chemrev.1c00107</a>."},"type":"journal_article","author":[{"first_name":"John A.","full_name":"Keith, John A.","last_name":"Keith"},{"first_name":"Valentin","full_name":"Valentin Vassilev-Galindo, Valentin","last_name":"Valentin Vassilev-Galindo"},{"id":"cbe3cda4-d82c-11eb-8dc7-8ff94289fcc9","orcid":"0000-0002-3584-9632","last_name":"Cheng","first_name":"Bingqing","full_name":"Cheng, Bingqing"},{"full_name":"Chmiela, Stefan","first_name":"Stefan","last_name":"Chmiela"},{"full_name":"Gastegger, Michael","first_name":"Michael","last_name":"Gastegger"},{"full_name":"Müller, Klaus-Robert","first_name":"Klaus-Robert","last_name":"Müller"},{"full_name":"Tkatchenko, Alexandre","first_name":"Alexandre","last_name":"Tkatchenko"}],"day":"07","main_file_link":[{"url":"https://doi.org/10.1021/acs.chemrev.1c00107","open_access":"1"}],"oa":1,"publication_status":"published","volume":121,"issue":"16","article_processing_charge":"No","arxiv":1,"_id":"9698","date_published":"2021-07-07T00:00:00Z","abstract":[{"lang":"eng","text":"Machine learning models are poised to make a transformative impact on chemical sciences by dramatically accelerating computational algorithms and amplifying insights available from computational chemistry methods. However, achieving this requires a confluence and coaction of expertise in computer science and physical sciences. This review is written for new and experienced researchers working at the intersection of both fields. We first provide concise tutorials of computational chemistry and machine learning methods, showing how insights involving both can be achieved. We then follow with a critical review of noteworthy applications that demonstrate how computational chemistry and machine learning can be used together to provide insightful (and useful) predictions in molecular and materials modeling, retrosyntheses, catalysis, and drug design."}],"publication_identifier":{"eissn":["1520-6890"],"issn":["0009-2665"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2023-05-08T11:31:03Z","scopus_import":"1","external_id":{"arxiv":["2102.06321"]},"oa_version":"Published Version","year":"2021","article_type":"review"},{"oa_version":"Published Version","year":"2021","has_accepted_license":"1","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","date_updated":"2024-02-28T13:14:39Z","acknowledged_ssus":[{"_id":"M-Shop"}],"publication_identifier":{"issn":["2663-337X"]},"file":[{"file_id":"9744","relation":"source_file","content_type":"application/x-zip-compressed","embargo_to":"open_access","date_created":"2021-07-28T13:32:02Z","file_size":22859658,"creator":"nagrawal","file_name":"Transition to Turbulence and Drag Reduction in Particle-Laden Pipe Flows.zip","access_level":"closed","date_updated":"2022-07-29T22:30:05Z","checksum":"77436be3563a90435024307b1b5ee7e8"},{"date_created":"2021-07-28T13:32:05Z","content_type":"application/pdf","file_id":"9745","relation":"main_file","checksum":"72a891d7daba85445c29b868c22575ed","date_updated":"2022-07-29T22:30:05Z","access_level":"open_access","file_name":"Transition to Turbulence and Drag Reduction in Particle-Laden Pipe Flows.pdf","file_size":18658048,"creator":"nagrawal","embargo":"2022-07-28"}],"_id":"9728","date_published":"2021-07-29T00:00:00Z","abstract":[{"lang":"eng","text":"Most real-world flows are multiphase, yet we know little about them compared to their single-phase counterparts. Multiphase flows are more difficult to investigate as their dynamics occur in large parameter space and involve complex phenomena such as preferential concentration, turbulence modulation, non-Newtonian rheology, etc. Over the last few decades, experiments in particle-laden flows have taken a back seat in favour of ever-improving computational resources. However, computers are still not powerful enough to simulate a real-world fluid with millions of finite-size particles. Experiments are essential not only because they offer a reliable way to investigate real-world multiphase flows but also because they serve to validate numerical studies and steer the research in a relevant direction. In this work, we have experimentally investigated particle-laden flows in pipes, and in particular, examined the effect of particles on the laminar-turbulent transition and the drag scaling in turbulent flows.\r\n\r\nFor particle-laden pipe flows, an earlier study [Matas et al., 2003] reported how the sub-critical (i.e., hysteretic) transition that occurs via localised turbulent structures called puffs is affected by the addition of particles. In this study, in addition to this known transition, we found a super-critical transition to a globally fluctuating state with increasing particle concentration. At the same time, the Newtonian-type transition via puffs is delayed to larger Reynolds numbers. At an even higher concentration, only the globally fluctuating state is found. The dynamics of particle-laden flows are hence determined by two competing instabilities that give rise to three flow regimes: Newtonian-type turbulence at low, a particle-induced globally fluctuating state at high, and a coexistence state at intermediate concentrations.\r\n\r\nThe effect of particles on turbulent drag is ambiguous, with studies reporting drag reduction, no net change, and even drag increase. The ambiguity arises because, in addition to particle concentration, particle shape, size, and density also affect the net drag. Even similar particles might affect the flow dissimilarly in different Reynolds number and concentration ranges. In the present study, we explored a wide range of both Reynolds number and concentration, using spherical as well as cylindrical particles. We found that the spherical particles do not reduce drag while the cylindrical particles are drag-reducing within a specific Reynolds number interval. The interval strongly depends on the particle concentration and the relative size of the pipe and particles. Within this interval, the magnitude of drag reduction reaches a maximum. These drag reduction maxima appear to fall onto a distinct power-law curve irrespective of the pipe diameter and particle concentration, and this curve can be considered as the maximum drag reduction asymptote for a given fibre shape. Such an asymptote is well known for polymeric flows but had not been identified for particle-laden flows prior to this work."}],"article_processing_charge":"No","file_date_updated":"2022-07-29T22:30:05Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"publication_status":"published","oa":1,"day":"29","type":"dissertation","author":[{"id":"469E6004-F248-11E8-B48F-1D18A9856A87","first_name":"Nishchal","full_name":"Agrawal, Nishchal","last_name":"Agrawal"}],"alternative_title":["ISTA Thesis"],"citation":{"apa":"Agrawal, N. (2021). <i>Transition to turbulence and drag reduction in particle-laden pipe flows</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/at:ista:9728\">https://doi.org/10.15479/at:ista:9728</a>","ama":"Agrawal N. Transition to turbulence and drag reduction in particle-laden pipe flows. 2021. doi:<a href=\"https://doi.org/10.15479/at:ista:9728\">10.15479/at:ista:9728</a>","short":"N. Agrawal, Transition to Turbulence and Drag Reduction in Particle-Laden Pipe Flows, Institute of Science and Technology Austria, 2021.","mla":"Agrawal, Nishchal. <i>Transition to Turbulence and Drag Reduction in Particle-Laden Pipe Flows</i>. Institute of Science and Technology Austria, 2021, doi:<a href=\"https://doi.org/10.15479/at:ista:9728\">10.15479/at:ista:9728</a>.","ieee":"N. Agrawal, “Transition to turbulence and drag reduction in particle-laden pipe flows,” Institute of Science and Technology Austria, 2021.","ista":"Agrawal N. 2021. Transition to turbulence and drag reduction in particle-laden pipe flows. Institute of Science and Technology Austria.","chicago":"Agrawal, Nishchal. “Transition to Turbulence and Drag Reduction in Particle-Laden Pipe Flows.” Institute of Science and Technology Austria, 2021. <a href=\"https://doi.org/10.15479/at:ista:9728\">https://doi.org/10.15479/at:ista:9728</a>."},"title":"Transition to turbulence and drag reduction in particle-laden pipe flows","keyword":["Drag Reduction","Transition to Turbulence","Multiphase Flows","particle Laden Flows","Complex Flows","Experiments","Fluid Dynamics"],"language":[{"iso":"eng"}],"doi":"10.15479/at:ista:9728","ddc":["532"],"related_material":{"record":[{"id":"6189","relation":"part_of_dissertation","status":"public"}]},"month":"07","supervisor":[{"last_name":"Hof","full_name":"Hof, Björn","first_name":"Björn","id":"3A374330-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-2057-2754"}],"date_created":"2021-07-27T13:40:30Z","page":"118","department":[{"_id":"GradSch"},{"_id":"BjHo"}],"status":"public","publisher":"Institute of Science and Technology Austria","degree_awarded":"PhD"},{"ec_funded":1,"citation":{"apa":"Feliciangeli, D. (2021). <i>The polaron at strong coupling</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/at:ista:9733\">https://doi.org/10.15479/at:ista:9733</a>","ama":"Feliciangeli D. The polaron at strong coupling. 2021. doi:<a href=\"https://doi.org/10.15479/at:ista:9733\">10.15479/at:ista:9733</a>","short":"D. Feliciangeli, The Polaron at Strong Coupling, Institute of Science and Technology Austria, 2021.","mla":"Feliciangeli, Dario. <i>The Polaron at Strong Coupling</i>. Institute of Science and Technology Austria, 2021, doi:<a href=\"https://doi.org/10.15479/at:ista:9733\">10.15479/at:ista:9733</a>.","ieee":"D. Feliciangeli, “The polaron at strong coupling,” Institute of Science and Technology Austria, 2021.","ista":"Feliciangeli D. 2021. The polaron at strong coupling. Institute of Science and Technology Austria.","chicago":"Feliciangeli, Dario. “The Polaron at Strong Coupling.” Institute of Science and Technology Austria, 2021. <a href=\"https://doi.org/10.15479/at:ista:9733\">https://doi.org/10.15479/at:ista:9733</a>."},"title":"The polaron at strong coupling","day":"20","alternative_title":["ISTA Thesis"],"type":"dissertation","author":[{"orcid":"0000-0003-0754-8530","id":"41A639AA-F248-11E8-B48F-1D18A9856A87","full_name":"Feliciangeli, Dario","first_name":"Dario","last_name":"Feliciangeli"}],"project":[{"grant_number":"716117","name":"Optimal Transport and Stochastic Dynamics","_id":"256E75B8-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"},{"grant_number":"694227","name":"Analysis of quantum many-body systems","call_identifier":"H2020","_id":"25C6DC12-B435-11E9-9278-68D0E5697425"},{"grant_number":"F6504","name":"Taming Complexity in Partial Differential Systems","_id":"fc31cba2-9c52-11eb-aca3-ff467d239cd2"}],"related_material":{"record":[{"status":"public","relation":"part_of_dissertation","id":"9787"},{"id":"9792","relation":"part_of_dissertation","status":"public"},{"id":"9225","relation":"part_of_dissertation","status":"public"},{"status":"public","id":"9781","relation":"part_of_dissertation"},{"status":"public","id":"9791","relation":"part_of_dissertation"}]},"language":[{"iso":"eng"}],"ddc":["515","519","539"],"doi":"10.15479/at:ista:9733","page":"180","month":"08","date_created":"2021-07-27T15:48:30Z","supervisor":[{"id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6781-0521","last_name":"Seiringer","first_name":"Robert","full_name":"Seiringer, Robert"},{"orcid":"0000-0002-0845-1338","id":"4C5696CE-F248-11E8-B48F-1D18A9856A87","full_name":"Maas, Jan","first_name":"Jan","last_name":"Maas"}],"publisher":"Institute of Science and Technology Austria","degree_awarded":"PhD","department":[{"_id":"GradSch"},{"_id":"RoSe"},{"_id":"JaMa"}],"status":"public","year":"2021","oa_version":"Published Version","has_accepted_license":"1","date_updated":"2024-03-06T12:30:44Z","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","publication_identifier":{"issn":["2663-337X"]},"article_processing_charge":"No","file":[{"file_name":"Thesis_FeliciangeliA.pdf","creator":"dfelicia","file_size":1958710,"checksum":"e88bb8ca43948abe060eb2d2fa719881","date_updated":"2021-09-06T09:28:56Z","access_level":"open_access","content_type":"application/pdf","file_id":"9944","relation":"main_file","date_created":"2021-08-19T14:03:48Z"},{"creator":"dfelicia","file_size":3771669,"file_name":"thesis.7z","checksum":"72810843abee83705853505b3f8348aa","access_level":"closed","date_updated":"2022-03-10T12:13:57Z","file_id":"9945","relation":"source_file","content_type":"application/octet-stream","date_created":"2021-08-19T14:06:35Z"}],"_id":"9733","abstract":[{"lang":"eng","text":"This thesis is the result of the research carried out by the author during his PhD at IST Austria between 2017 and 2021. It mainly focuses on the Fröhlich polaron model, specifically to its regime of strong coupling. This model, which is rigorously introduced and discussed in the introduction, has been of great interest in condensed matter physics and field theory for more than eighty years. It is used to describe an electron interacting with the atoms of a solid material (the strength of this interaction is modeled by the presence of a coupling constant α in the Hamiltonian of the system). The particular regime examined here, which is mathematically described by considering the limit α →∞, displays many interesting features related to the emergence of classical behavior, which allows for a simplified effective description of the system under analysis. The properties, the range of validity and a quantitative analysis of the precision of such classical approximations are the main object of the present work. We specify our investigation to the study of the ground state energy of the system, its dynamics and its effective mass. For each of these problems, we provide in the introduction an overview of the previously known results and a detailed account of the original contributions by the author."}],"date_published":"2021-08-20T00:00:00Z","license":"https://creativecommons.org/licenses/by-nd/4.0/","publication_status":"published","oa":1,"file_date_updated":"2022-03-10T12:13:57Z","tmp":{"name":"Creative Commons Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0)","image":"/image/cc_by_nd.png","legal_code_url":"https://creativecommons.org/licenses/by-nd/4.0/legalcode","short":"CC BY-ND (4.0)"}},{"external_id":{"pmid":["34318749"],"isi":["000692027800001"]},"scopus_import":"1","date_updated":"2023-08-11T10:26:29Z","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","publication_identifier":{"eissn":["2050-084X"]},"article_type":"original","oa_version":"Published Version","year":"2021","publication_status":"published","main_file_link":[{"open_access":"1","url":"https://doi.org/10.7554/eLife.68876"}],"oa":1,"volume":10,"article_processing_charge":"No","article_number":"e68876","_id":"9746","date_published":"2021-07-28T00:00:00Z","abstract":[{"lang":"eng","text":"Evolutionary adaptation is a major source of antibiotic resistance in bacterial pathogens. Evolution-informed therapy aims to constrain resistance by accounting for bacterial evolvability. Sequential treatments with antibiotics that target different bacterial processes were previously shown to limit adaptation through genetic resistance trade-offs and negative hysteresis. Treatment with homogeneous sets of antibiotics is generally viewed to be disadvantageous, as it should rapidly lead to cross-resistance. We here challenged this assumption by determining the evolutionary response of Pseudomonas aeruginosa to experimental sequential treatments involving both heterogenous and homogeneous antibiotic sets. To our surprise, we found that fast switching between only β-lactam antibiotics resulted in increased extinction of bacterial populations. We demonstrate that extinction is favored by low rates of spontaneous resistance emergence and low levels of spontaneous cross-resistance among the antibiotics in sequence. The uncovered principles may help to guide the optimized use of available antibiotics in highly potent, evolution-informed treatment designs."}],"pmid":1,"acknowledgement":"We would like to thank Leif Tueffers and João Botelho for discussions and suggestions as well as Kira Haas and Julia Bunk for technical support. We acknowledge financial support from the German Science Foundation (grant SCHU 1415/12-2 to HS, and funding under Germany’s Excellence Strategy EXC 2167–390884018 as well as the Research Training Group 2501 TransEvo to HS and SN), the Max Planck Society (IMPRS scholarship to AB; Max-Planck fellowship to HS), and the Leibniz Science Campus Evolutionary Medicine of the Lung (EvoLUNG, to HS and SN). This work was further supported by the German Science Foundation Research Infrastructure NGS_CC (project 407495230) as part of the Next Generation Sequencing Competence Network (project 423957469). NGS analyses were carried out at the Competence Centre for Genomic Analysis Kiel (CCGA Kiel).","language":[{"iso":"eng"}],"doi":"10.7554/elife.68876","citation":{"chicago":"Batra, Aditi, Roderich Römhild, Emilie Rousseau, Sören Franzenburg, Stefan Niemann, and Hinrich Schulenburg. “High Potency of Sequential Therapy with Only Beta-Lactam Antibiotics.” <i>ELife</i>. eLife Sciences Publications, 2021. <a href=\"https://doi.org/10.7554/elife.68876\">https://doi.org/10.7554/elife.68876</a>.","ieee":"A. Batra, R. Römhild, E. Rousseau, S. Franzenburg, S. Niemann, and H. Schulenburg, “High potency of sequential therapy with only beta-lactam antibiotics,” <i>eLife</i>, vol. 10. eLife Sciences Publications, 2021.","ista":"Batra A, Römhild R, Rousseau E, Franzenburg S, Niemann S, Schulenburg H. 2021. High potency of sequential therapy with only beta-lactam antibiotics. eLife. 10, e68876.","mla":"Batra, Aditi, et al. “High Potency of Sequential Therapy with Only Beta-Lactam Antibiotics.” <i>ELife</i>, vol. 10, e68876, eLife Sciences Publications, 2021, doi:<a href=\"https://doi.org/10.7554/elife.68876\">10.7554/elife.68876</a>.","short":"A. Batra, R. Römhild, E. Rousseau, S. Franzenburg, S. Niemann, H. Schulenburg, ELife 10 (2021).","ama":"Batra A, Römhild R, Rousseau E, Franzenburg S, Niemann S, Schulenburg H. High potency of sequential therapy with only beta-lactam antibiotics. <i>eLife</i>. 2021;10. doi:<a href=\"https://doi.org/10.7554/elife.68876\">10.7554/elife.68876</a>","apa":"Batra, A., Römhild, R., Rousseau, E., Franzenburg, S., Niemann, S., &#38; Schulenburg, H. (2021). High potency of sequential therapy with only beta-lactam antibiotics. <i>ELife</i>. eLife Sciences Publications. <a href=\"https://doi.org/10.7554/elife.68876\">https://doi.org/10.7554/elife.68876</a>"},"title":"High potency of sequential therapy with only beta-lactam antibiotics","day":"28","type":"journal_article","author":[{"full_name":"Batra, Aditi","first_name":"Aditi","last_name":"Batra"},{"last_name":"Römhild","full_name":"Römhild, Roderich","first_name":"Roderich","id":"68E56E44-62B0-11EA-B963-444F3DDC885E","orcid":"0000-0001-9480-5261"},{"last_name":"Rousseau","first_name":"Emilie","full_name":"Rousseau, Emilie"},{"last_name":"Franzenburg","first_name":"Sören","full_name":"Franzenburg, Sören"},{"first_name":"Stefan","full_name":"Niemann, Stefan","last_name":"Niemann"},{"last_name":"Schulenburg","full_name":"Schulenburg, Hinrich","first_name":"Hinrich"}],"publisher":"eLife Sciences Publications","isi":1,"publication":"eLife","quality_controlled":"1","department":[{"_id":"CaGu"}],"status":"public","intvolume":"        10","month":"07","date_created":"2021-07-28T13:36:57Z"},{"department":[{"_id":"RySh"},{"_id":"EM-Fac"}],"quality_controlled":"1","publication":" Receptor and Ion Channel Detection in the Brain","status":"public","intvolume":"       169","publisher":"Humana","place":"New York","month":"07","series_title":"Neuromethods","date_created":"2021-07-30T09:34:56Z","page":"267-283","language":[{"iso":"eng"}],"keyword":["Freeze-fracture replica: Deep learning","Immunogold labeling","Integral membrane protein","Electron microscopy"],"doi":"10.1007/978-1-0716-1522-5_19","ddc":["573"],"acknowledgement":"This work was supported by the European Union (European Research Council Advanced grant no. 694539 and Human Brain Project Ref. 720270 to R. S.) and the Austrian Academy of Sciences (DOC fellowship to D.K.).","project":[{"_id":"25CA28EA-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"In situ analysis of single channel subunit composition in neurons: physiological implication in synaptic plasticity and behaviour","grant_number":"694539"},{"call_identifier":"H2020","_id":"25CBA828-B435-11E9-9278-68D0E5697425","name":"Human Brain Project Specific Grant Agreement 1 (HBP SGA 1)","grant_number":"720270"}],"related_material":{"record":[{"status":"public","relation":"dissertation_contains","id":"9562"}]},"day":"27","alternative_title":["Neuromethods"],"type":"book_chapter","author":[{"id":"3F99E422-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-9735-5315","last_name":"Kaufmann","full_name":"Kaufmann, Walter","first_name":"Walter"},{"id":"42E121A4-F248-11E8-B48F-1D18A9856A87","full_name":"Kleindienst, David","first_name":"David","last_name":"Kleindienst"},{"full_name":"Harada, Harumi","first_name":"Harumi","last_name":"Harada","orcid":"0000-0001-7429-7896","id":"2E55CDF2-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","full_name":"Shigemoto, Ryuichi","first_name":"Ryuichi"}],"ec_funded":1,"citation":{"short":"W. Kaufmann, D. Kleindienst, H. Harada, R. Shigemoto, in:,  Receptor and Ion Channel Detection in the Brain, Humana, New York, 2021, pp. 267–283.","ama":"Kaufmann W, Kleindienst D, Harada H, Shigemoto R. High-Resolution localization and quantitation of membrane proteins by SDS-digested freeze-fracture replica labeling (SDS-FRL). In: <i> Receptor and Ion Channel Detection in the Brain</i>. Vol 169. Neuromethods. New York: Humana; 2021:267-283. doi:<a href=\"https://doi.org/10.1007/978-1-0716-1522-5_19\">10.1007/978-1-0716-1522-5_19</a>","apa":"Kaufmann, W., Kleindienst, D., Harada, H., &#38; Shigemoto, R. (2021). High-Resolution localization and quantitation of membrane proteins by SDS-digested freeze-fracture replica labeling (SDS-FRL). In <i> Receptor and Ion Channel Detection in the Brain</i> (Vol. 169, pp. 267–283). New York: Humana. <a href=\"https://doi.org/10.1007/978-1-0716-1522-5_19\">https://doi.org/10.1007/978-1-0716-1522-5_19</a>","chicago":"Kaufmann, Walter, David Kleindienst, Harumi Harada, and Ryuichi Shigemoto. “High-Resolution Localization and Quantitation of Membrane Proteins by SDS-Digested Freeze-Fracture Replica Labeling (SDS-FRL).” In <i> Receptor and Ion Channel Detection in the Brain</i>, 169:267–83. Neuromethods. New York: Humana, 2021. <a href=\"https://doi.org/10.1007/978-1-0716-1522-5_19\">https://doi.org/10.1007/978-1-0716-1522-5_19</a>.","ista":"Kaufmann W, Kleindienst D, Harada H, Shigemoto R. 2021.High-Resolution localization and quantitation of membrane proteins by SDS-digested freeze-fracture replica labeling (SDS-FRL). In:  Receptor and Ion Channel Detection in the Brain. Neuromethods, vol. 169, 267–283.","ieee":"W. Kaufmann, D. Kleindienst, H. Harada, and R. Shigemoto, “High-Resolution localization and quantitation of membrane proteins by SDS-digested freeze-fracture replica labeling (SDS-FRL),” in <i> Receptor and Ion Channel Detection in the Brain</i>, vol. 169, New York: Humana, 2021, pp. 267–283.","mla":"Kaufmann, Walter, et al. “High-Resolution Localization and Quantitation of Membrane Proteins by SDS-Digested Freeze-Fracture Replica Labeling (SDS-FRL).” <i> Receptor and Ion Channel Detection in the Brain</i>, vol. 169, Humana, 2021, pp. 267–83, doi:<a href=\"https://doi.org/10.1007/978-1-0716-1522-5_19\">10.1007/978-1-0716-1522-5_19</a>."},"title":"High-Resolution localization and quantitation of membrane proteins by SDS-digested freeze-fracture replica labeling (SDS-FRL)","volume":169,"publication_status":"published","date_published":"2021-07-27T00:00:00Z","_id":"9756","abstract":[{"lang":"eng","text":"High-resolution visualization and quantification of membrane proteins contribute to the understanding of their functions and the roles they play in physiological and pathological conditions. Sodium dodecyl sulfate-digested freeze-fracture replica labeling (SDS-FRL) is a powerful electron microscopy method to study quantitatively the two-dimensional distribution of transmembrane proteins and their tightly associated proteins. During treatment with SDS, intracellular organelles and proteins not anchored to the replica are dissolved, whereas integral membrane proteins captured and stabilized by carbon/platinum deposition remain on the replica. Their intra- and extracellular domains become exposed on the surface of the replica, facilitating the accessibility of antibodies and, therefore, providing higher labeling efficiency than those obtained with other immunoelectron microscopy techniques. In this chapter, we describe the protocols of SDS-FRL adapted for mammalian brain samples, and optimization of the SDS treatment to increase the labeling efficiency for quantification of Cav2.1, the alpha subunit of P/Q-type voltage-dependent calcium channels utilizing deep learning algorithms."}],"article_processing_charge":"No","date_updated":"2024-03-25T23:30:16Z","user_id":"D865714E-FA4E-11E9-B85B-F5C5E5697425","publication_identifier":{"isbn":["9781071615218"],"eisbn":["9781071615225"]},"year":"2021","oa_version":"None","has_accepted_license":"1"},{"publisher":"Public Library of Science","isi":1,"publication":"PLoS Computational Biology","department":[{"_id":"CaHe"}],"intvolume":"        17","status":"public","month":"07","date_created":"2021-08-01T22:01:21Z","pmid":1,"acknowledgement":"The authors thank Inez Lam of Johns Hopkins University for valuable comments on an earlier version of the manuscript. We also thank the facilitators of the 2019–2020 eLife Community Ambassador program.","language":[{"iso":"eng"}],"doi":"10.1371/journal.pcbi.1009124","ddc":["613"],"citation":{"short":"M.J. Bartlett, F.N. Arslan, A. Bankston, S. Sarabipour, PLoS Computational Biology 17 (2021).","ama":"Bartlett MJ, Arslan FN, Bankston A, Sarabipour S. Ten simple rules to improve academic work- life balance. <i>PLoS Computational Biology</i>. 2021;17(7). doi:<a href=\"https://doi.org/10.1371/journal.pcbi.1009124\">10.1371/journal.pcbi.1009124</a>","apa":"Bartlett, M. J., Arslan, F. N., Bankston, A., &#38; Sarabipour, S. (2021). Ten simple rules to improve academic work- life balance. <i>PLoS Computational Biology</i>. Public Library of Science. <a href=\"https://doi.org/10.1371/journal.pcbi.1009124\">https://doi.org/10.1371/journal.pcbi.1009124</a>","chicago":"Bartlett, Michael John, Feyza N Arslan, Adriana Bankston, and Sarvenaz Sarabipour. “Ten Simple Rules to Improve Academic Work- Life Balance.” <i>PLoS Computational Biology</i>. Public Library of Science, 2021. <a href=\"https://doi.org/10.1371/journal.pcbi.1009124\">https://doi.org/10.1371/journal.pcbi.1009124</a>.","ieee":"M. J. Bartlett, F. N. Arslan, A. Bankston, and S. Sarabipour, “Ten simple rules to improve academic work- life balance,” <i>PLoS Computational Biology</i>, vol. 17, no. 7. Public Library of Science, 2021.","ista":"Bartlett MJ, Arslan FN, Bankston A, Sarabipour S. 2021. Ten simple rules to improve academic work- life balance. PLoS Computational Biology. 17(7), e1009124.","mla":"Bartlett, Michael John, et al. “Ten Simple Rules to Improve Academic Work- Life Balance.” <i>PLoS Computational Biology</i>, vol. 17, no. 7, e1009124, Public Library of Science, 2021, doi:<a href=\"https://doi.org/10.1371/journal.pcbi.1009124\">10.1371/journal.pcbi.1009124</a>."},"title":"Ten simple rules to improve academic work- life balance","day":"15","author":[{"last_name":"Bartlett","full_name":"Bartlett, Michael John","first_name":"Michael John"},{"id":"49DA7910-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5809-9566","last_name":"Arslan","full_name":"Arslan, Feyza N","first_name":"Feyza N"},{"last_name":"Bankston","full_name":"Bankston, Adriana","first_name":"Adriana"},{"full_name":"Sarabipour, Sarvenaz","first_name":"Sarvenaz","last_name":"Sarabipour"}],"type":"journal_article","publication_status":"published","oa":1,"file_date_updated":"2021-08-05T12:06:49Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"volume":17,"article_processing_charge":"Yes","issue":"7","article_number":"e1009124","file":[{"file_name":"2021_PlosCompBio_Bartlett.pdf","file_size":693633,"creator":"cchlebak","date_updated":"2021-08-05T12:06:49Z","access_level":"open_access","checksum":"e56d91f0eeadb36f143a90e2c1b3ab63","content_type":"application/pdf","relation":"main_file","file_id":"9771","date_created":"2021-08-05T12:06:49Z"}],"_id":"9759","date_published":"2021-07-15T00:00:00Z","external_id":{"isi":["000677713500008"],"pmid":["34264932"]},"scopus_import":"1","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","date_updated":"2023-08-10T14:16:46Z","publication_identifier":{"issn":["1553734X"],"eissn":["15537358"]},"article_type":"letter_note","has_accepted_license":"1","year":"2021","oa_version":"Published Version"},{"ec_funded":1,"citation":{"apa":"Sack, S., &#38; Serbyn, M. (2021). Quantum annealing initialization of the quantum approximate optimization algorithm. <i>Quantum</i>. Verein zur Förderung des Open Access Publizierens in den Quantenwissenschaften. <a href=\"https://doi.org/10.22331/Q-2021-07-01-491\">https://doi.org/10.22331/Q-2021-07-01-491</a>","ama":"Sack S, Serbyn M. Quantum annealing initialization of the quantum approximate optimization algorithm. <i>Quantum</i>. 2021;5. doi:<a href=\"https://doi.org/10.22331/Q-2021-07-01-491\">10.22331/Q-2021-07-01-491</a>","short":"S. Sack, M. Serbyn, Quantum 5 (2021).","mla":"Sack, Stefan, and Maksym Serbyn. “Quantum Annealing Initialization of the Quantum Approximate Optimization Algorithm.” <i>Quantum</i>, vol. 5, 491, Verein zur Förderung des Open Access Publizierens in den Quantenwissenschaften, 2021, doi:<a href=\"https://doi.org/10.22331/Q-2021-07-01-491\">10.22331/Q-2021-07-01-491</a>.","ieee":"S. Sack and M. Serbyn, “Quantum annealing initialization of the quantum approximate optimization algorithm,” <i>Quantum</i>, vol. 5. Verein zur Förderung des Open Access Publizierens in den Quantenwissenschaften, 2021.","ista":"Sack S, Serbyn M. 2021. Quantum annealing initialization of the quantum approximate optimization algorithm. Quantum. 5, 491.","chicago":"Sack, Stefan, and Maksym Serbyn. “Quantum Annealing Initialization of the Quantum Approximate Optimization Algorithm.” <i>Quantum</i>. Verein zur Förderung des Open Access Publizierens in den Quantenwissenschaften, 2021. <a href=\"https://doi.org/10.22331/Q-2021-07-01-491\">https://doi.org/10.22331/Q-2021-07-01-491</a>."},"title":"Quantum annealing initialization of the quantum approximate optimization algorithm","day":"01","type":"journal_article","author":[{"last_name":"Sack","full_name":"Sack, Stefan","first_name":"Stefan","id":"dd622248-f6e0-11ea-865d-ce382a1c81a5","orcid":"0000-0001-5400-8508"},{"last_name":"Serbyn","first_name":"Maksym","full_name":"Serbyn, Maksym","id":"47809E7E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2399-5827"}],"acknowledgement":"We would like to thank D. Abanin and R. Medina for fruitful discussions and A. Smith and I. Kim for valuable feedback on the manuscript. We acknowledge support by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (Grant Agreement No. 850899).","related_material":{"record":[{"status":"public","id":"14622","relation":"dissertation_contains"}]},"project":[{"grant_number":"850899","name":"Non-Ergodic Quantum Matter: Universality, Dynamics and Control","call_identifier":"H2020","_id":"23841C26-32DE-11EA-91FC-C7463DDC885E"}],"language":[{"iso":"eng"}],"ddc":["530"],"doi":"10.22331/Q-2021-07-01-491","month":"07","date_created":"2021-08-01T22:01:21Z","publisher":"Verein zur Förderung des Open Access Publizierens in den Quantenwissenschaften","isi":1,"quality_controlled":"1","department":[{"_id":"GradSch"},{"_id":"MaSe"}],"publication":"Quantum","status":"public","intvolume":"         5","article_type":"original","oa_version":"Published Version","year":"2021","has_accepted_license":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2023-12-13T14:47:25Z","scopus_import":"1","external_id":{"arxiv":["2101.05742"],"isi":["000669830600001"]},"publication_identifier":{"eissn":["2521-327X"]},"arxiv":1,"article_processing_charge":"Yes","file":[{"relation":"main_file","file_id":"9774","content_type":"application/pdf","date_created":"2021-08-06T06:44:31Z","creator":"cchlebak","file_size":2312482,"file_name":"2021_Quantum_Sack.pdf","access_level":"open_access","date_updated":"2021-08-06T06:44:31Z","checksum":"9706c2bb8e748e9b5b138381995a7f6f"}],"article_number":"491","_id":"9760","date_published":"2021-07-01T00:00:00Z","abstract":[{"lang":"eng","text":"The quantum approximate optimization algorithm (QAOA) is a prospective near-term quantum algorithm due to its modest circuit depth and promising benchmarks. However, an external parameter optimization required in the QAOA could become a performance bottleneck. This motivates studies of the optimization landscape and search for heuristic ways of parameter initialization. In this work we visualize the optimization landscape of the QAOA applied to the MaxCut problem on random graphs, demonstrating that random initialization of the QAOA is prone to converging to local minima with suboptimal performance. We introduce the initialization of QAOA parameters based on the Trotterized quantum annealing (TQA) protocol, parameterized by the Trotter time step. We find that the TQA initialization allows to circumvent\r\nthe issue of false minima for a broad range of time steps, yielding the same performance as the best result out of an exponentially scaling number of random initializations. Moreover, we demonstrate that the optimal value of the time step coincides with the point of proliferation of Trotter errors in quantum annealing. Our results suggest practical ways of initializing QAOA protocols on near-term quantum devices and reveal new connections between QAOA and quantum annealing."}],"publication_status":"published","oa":1,"file_date_updated":"2021-08-06T06:44:31Z","volume":5,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"}},{"article_number":"1593","file":[{"content_type":"application/pdf","relation":"main_file","file_id":"9768","date_created":"2021-08-04T14:01:30Z","success":1,"file_name":"2021_Cells_Muench.pdf","file_size":4555611,"creator":"cziletti","checksum":"e0497ce5c77fa3b65a538c7d6e0f6c66","date_updated":"2021-08-04T14:01:30Z","access_level":"open_access"}],"date_published":"2021-06-25T00:00:00Z","_id":"9761","abstract":[{"lang":"eng","text":"The important roles of mitochondrial function and dysfunction in the process of neurodegeneration are widely acknowledged. Retinal ganglion cells (RGCs) appear to be a highly vulnerable neuronal cell type in the central nervous system with respect to mitochondrial dysfunction but the actual reasons for this are still incompletely understood. These cells have a unique circumstance where unmyelinated axons must bend nearly 90° to exit the eye and then cross a translaminar pressure gradient before becoming myelinated in the optic nerve. This region, the optic nerve head, contains some of the highest density of mitochondria present in these cells. Glaucoma represents a perfect storm of events occurring at this location, with a combination of changes in the translaminar pressure gradient and reassignment of the metabolic support functions of supporting glia, which appears to apply increased metabolic stress to the RGC axons leading to a failure of axonal transport mechanisms. However, RGCs themselves are also extremely sensitive to genetic mutations, particularly in genes affecting mitochondrial dynamics and mitochondrial clearance. These mutations, which systemically affect the mitochondria in every cell, often lead to an optic neuropathy as the sole pathologic defect in affected patients. This review summarizes knowledge of mitochondrial structure and function, the known energy demands of neurons in general, and places these in the context of normal and pathological characteristics of mitochondria attributed to RGCs. "}],"article_processing_charge":"Yes","issue":"7","file_date_updated":"2021-08-04T14:01:30Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"volume":10,"publication_status":"published","oa":1,"article_type":"original","year":"2021","oa_version":"Published Version","has_accepted_license":"1","external_id":{"isi":["000678193300001"],"pmid":["34201955"]},"scopus_import":"1","date_updated":"2023-08-10T14:14:53Z","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","publication_identifier":{"eissn":["20734409"]},"month":"06","date_created":"2021-08-01T22:01:22Z","publication":"Cells","quality_controlled":"1","department":[{"_id":"SaSi"}],"status":"public","intvolume":"        10","publisher":"MDPI","isi":1,"day":"25","type":"journal_article","author":[{"last_name":"Muench","first_name":"Nicole A.","full_name":"Muench, Nicole A."},{"last_name":"Patel","full_name":"Patel, Sonia","first_name":"Sonia"},{"orcid":"0000-0001-9642-1085","id":"3838F452-F248-11E8-B48F-1D18A9856A87","last_name":"Maes","full_name":"Maes, Margaret E","first_name":"Margaret E"},{"last_name":"Donahue","full_name":"Donahue, Ryan J.","first_name":"Ryan J."},{"last_name":"Ikeda","full_name":"Ikeda, Akihiro","first_name":"Akihiro"},{"full_name":"Nickells, Robert W.","first_name":"Robert W.","last_name":"Nickells"}],"citation":{"mla":"Muench, Nicole A., et al. “The Influence of Mitochondrial Dynamics and Function on Retinal Ganglion Cell Susceptibility in Optic Nerve Disease.” <i>Cells</i>, vol. 10, no. 7, 1593, MDPI, 2021, doi:<a href=\"https://doi.org/10.3390/cells10071593\">10.3390/cells10071593</a>.","ista":"Muench NA, Patel S, Maes ME, Donahue RJ, Ikeda A, Nickells RW. 2021. The influence of mitochondrial dynamics and function on retinal ganglion cell susceptibility in optic nerve disease. Cells. 10(7), 1593.","ieee":"N. A. Muench, S. Patel, M. E. Maes, R. J. Donahue, A. Ikeda, and R. W. Nickells, “The influence of mitochondrial dynamics and function on retinal ganglion cell susceptibility in optic nerve disease,” <i>Cells</i>, vol. 10, no. 7. MDPI, 2021.","chicago":"Muench, Nicole A., Sonia Patel, Margaret E Maes, Ryan J. Donahue, Akihiro Ikeda, and Robert W. Nickells. “The Influence of Mitochondrial Dynamics and Function on Retinal Ganglion Cell Susceptibility in Optic Nerve Disease.” <i>Cells</i>. MDPI, 2021. <a href=\"https://doi.org/10.3390/cells10071593\">https://doi.org/10.3390/cells10071593</a>.","apa":"Muench, N. A., Patel, S., Maes, M. E., Donahue, R. J., Ikeda, A., &#38; Nickells, R. W. (2021). The influence of mitochondrial dynamics and function on retinal ganglion cell susceptibility in optic nerve disease. <i>Cells</i>. MDPI. <a href=\"https://doi.org/10.3390/cells10071593\">https://doi.org/10.3390/cells10071593</a>","ama":"Muench NA, Patel S, Maes ME, Donahue RJ, Ikeda A, Nickells RW. The influence of mitochondrial dynamics and function on retinal ganglion cell susceptibility in optic nerve disease. <i>Cells</i>. 2021;10(7). doi:<a href=\"https://doi.org/10.3390/cells10071593\">10.3390/cells10071593</a>","short":"N.A. Muench, S. Patel, M.E. Maes, R.J. Donahue, A. Ikeda, R.W. Nickells, Cells 10 (2021)."},"title":"The influence of mitochondrial dynamics and function on retinal ganglion cell susceptibility in optic nerve disease","language":[{"iso":"eng"}],"doi":"10.3390/cells10071593","ddc":["570"],"pmid":1,"acknowledgement":"The authors are grateful to Kazuya Oikawa and Gillian McLellan for generously sharing some of their data for this review, and to Janis Eells for helpful comments on the manuscript."},{"language":[{"iso":"eng"}],"doi":"10.21468/scipostphys.11.1.008","ddc":["530"],"acknowledgement":"We thank Matthias Heinz and Volker Karle for helpful comments on the manuscript; Zoran Ristivojevic for useful correspondence regarding mean-field calculations of induced impurity-impurity interactions; Fabian Grusdt for sharing with us the data for the densities presented in Ref. [14]. This work has received funding from the DFG Project No. 413495248 [VO 2437/1-1] (F. B., H.-W. H., A. G. V.) and European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie Grant Agreement No. 754411 (A. G. V.). M. L. acknowledges support by the European Research Council (ERC) Starting Grant No. 801770 (ANGULON). H.-W.H. thanks the ECT* for hospitality during the workshop “Universal physics in Many-Body Quantum Systems – From Atoms to Quarks\". This infrastructure is part of a project that has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 824093. H.-W.H. was supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) - Project-ID 279384907 - SFB 1245.","project":[{"_id":"260C2330-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"754411","name":"ISTplus - Postdoctoral Fellowships"},{"call_identifier":"H2020","_id":"2688CF98-B435-11E9-9278-68D0E5697425","name":"Angulon: physics and applications of a new quasiparticle","grant_number":"801770"}],"day":"13","type":"journal_article","author":[{"last_name":"Brauneis","full_name":"Brauneis, Fabian","first_name":"Fabian"},{"last_name":"Hammer","full_name":"Hammer, Hans-Werner","first_name":"Hans-Werner"},{"id":"37CB05FA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6990-7802","last_name":"Lemeshko","first_name":"Mikhail","full_name":"Lemeshko, Mikhail"},{"id":"37D278BC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-0393-5525","last_name":"Volosniev","full_name":"Volosniev, Artem","first_name":"Artem"}],"ec_funded":1,"citation":{"ista":"Brauneis F, Hammer H-W, Lemeshko M, Volosniev A. 2021. Impurities in a one-dimensional Bose gas: The flow equation approach. SciPost Physics. 11(1), 008.","ieee":"F. Brauneis, H.-W. Hammer, M. Lemeshko, and A. Volosniev, “Impurities in a one-dimensional Bose gas: The flow equation approach,” <i>SciPost Physics</i>, vol. 11, no. 1. SciPost, 2021.","chicago":"Brauneis, Fabian, Hans-Werner Hammer, Mikhail Lemeshko, and Artem Volosniev. “Impurities in a One-Dimensional Bose Gas: The Flow Equation Approach.” <i>SciPost Physics</i>. SciPost, 2021. <a href=\"https://doi.org/10.21468/scipostphys.11.1.008\">https://doi.org/10.21468/scipostphys.11.1.008</a>.","mla":"Brauneis, Fabian, et al. “Impurities in a One-Dimensional Bose Gas: The Flow Equation Approach.” <i>SciPost Physics</i>, vol. 11, no. 1, 008, SciPost, 2021, doi:<a href=\"https://doi.org/10.21468/scipostphys.11.1.008\">10.21468/scipostphys.11.1.008</a>.","short":"F. Brauneis, H.-W. Hammer, M. Lemeshko, A. Volosniev, SciPost Physics 11 (2021).","apa":"Brauneis, F., Hammer, H.-W., Lemeshko, M., &#38; Volosniev, A. (2021). Impurities in a one-dimensional Bose gas: The flow equation approach. <i>SciPost Physics</i>. SciPost. <a href=\"https://doi.org/10.21468/scipostphys.11.1.008\">https://doi.org/10.21468/scipostphys.11.1.008</a>","ama":"Brauneis F, Hammer H-W, Lemeshko M, Volosniev A. Impurities in a one-dimensional Bose gas: The flow equation approach. <i>SciPost Physics</i>. 2021;11(1). doi:<a href=\"https://doi.org/10.21468/scipostphys.11.1.008\">10.21468/scipostphys.11.1.008</a>"},"title":"Impurities in a one-dimensional Bose gas: The flow equation approach","department":[{"_id":"MiLe"}],"quality_controlled":"1","publication":"SciPost Physics","intvolume":"        11","status":"public","publisher":"SciPost","isi":1,"month":"07","date_created":"2021-08-04T15:00:55Z","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","date_updated":"2023-08-11T10:25:44Z","external_id":{"arxiv":["2101.10958"],"isi":["000680039500013"]},"scopus_import":"1","publication_identifier":{"eissn":["2542-4653"]},"article_type":"original","has_accepted_license":"1","year":"2021","oa_version":"Published Version","file_date_updated":"2021-08-10T11:44:59Z","volume":11,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"publication_status":"published","oa":1,"article_number":"008","file":[{"content_type":"application/pdf","relation":"main_file","file_id":"9875","date_created":"2021-08-10T11:44:59Z","success":1,"file_name":"2021_SciPostPhysics_Brauneis.pdf","creator":"asandaue","file_size":1085300,"checksum":"eaa847346b1a023d97bbb291779610ed","date_updated":"2021-08-10T11:44:59Z","access_level":"open_access"}],"_id":"9769","abstract":[{"text":"A few years ago, flow equations were introduced as a technique for calculating the ground-state energies of cold Bose gases with and without impurities. In this paper, we extend this approach to compute observables other than the energy. As an example, we calculate the densities, and phase fluctuations of one-dimensional Bose gases with one and two impurities. For a single mobile impurity, we use flow equations to validate the mean-field results obtained upon the Lee-Low-Pines transformation. We show that the mean-field approximation is accurate for all values of the boson-impurity interaction strength as long as the phase coherence length is much larger than the healing length of the condensate. For two static impurities, we calculate impurity-impurity interactions induced by the Bose gas. We find that leading order perturbation theory fails when boson-impurity interactions are stronger than boson-boson interactions. The mean-field approximation reproduces the flow equation results for all values of the boson-impurity interaction strength as long as boson-boson interactions are weak.","lang":"eng"}],"date_published":"2021-07-13T00:00:00Z","arxiv":1,"issue":"1","article_processing_charge":"Yes"},{"acknowledgement":"We thank Rafael Barfknecht for useful discussions. This work has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie Grant Agreement No. 754411 (A.G.\r\nand A.G.V.). M.L. acknowledges support by the European Research Council (ERC) Starting Grant No. 801770 (ANGULON). Y.P. and O.M. acknowledge funding from the Nidersachsen Ministry of Science and Culture, and from the\r\nAcademia Sinica Research Program. O.M. is thankful for support through the Harry de Jur Chair in Applied Science.","project":[{"grant_number":"754411","name":"ISTplus - Postdoctoral Fellowships","_id":"260C2330-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"},{"call_identifier":"H2020","_id":"2688CF98-B435-11E9-9278-68D0E5697425","name":"Angulon: physics and applications of a new quasiparticle","grant_number":"801770"}],"language":[{"iso":"eng"}],"doi":"10.1103/physrevb.104.024430","ec_funded":1,"citation":{"short":"A. Volosniev, H. Alpern, Y. Paltiel, O. Millo, M. Lemeshko, A. Ghazaryan, Physical Review B 104 (2021).","ama":"Volosniev A, Alpern H, Paltiel Y, Millo O, Lemeshko M, Ghazaryan A. Interplay between friction and spin-orbit coupling as a source of spin polarization. <i>Physical Review B</i>. 2021;104(2). doi:<a href=\"https://doi.org/10.1103/physrevb.104.024430\">10.1103/physrevb.104.024430</a>","apa":"Volosniev, A., Alpern, H., Paltiel, Y., Millo, O., Lemeshko, M., &#38; Ghazaryan, A. (2021). Interplay between friction and spin-orbit coupling as a source of spin polarization. <i>Physical Review B</i>. American Physical Society. <a href=\"https://doi.org/10.1103/physrevb.104.024430\">https://doi.org/10.1103/physrevb.104.024430</a>","chicago":"Volosniev, Artem, Hen Alpern, Yossi Paltiel, Oded Millo, Mikhail Lemeshko, and Areg Ghazaryan. “Interplay between Friction and Spin-Orbit Coupling as a Source of Spin Polarization.” <i>Physical Review B</i>. American Physical Society, 2021. <a href=\"https://doi.org/10.1103/physrevb.104.024430\">https://doi.org/10.1103/physrevb.104.024430</a>.","ieee":"A. Volosniev, H. Alpern, Y. Paltiel, O. Millo, M. Lemeshko, and A. Ghazaryan, “Interplay between friction and spin-orbit coupling as a source of spin polarization,” <i>Physical Review B</i>, vol. 104, no. 2. American Physical Society, 2021.","ista":"Volosniev A, Alpern H, Paltiel Y, Millo O, Lemeshko M, Ghazaryan A. 2021. Interplay between friction and spin-orbit coupling as a source of spin polarization. Physical Review B. 104(2), 024430.","mla":"Volosniev, Artem, et al. “Interplay between Friction and Spin-Orbit Coupling as a Source of Spin Polarization.” <i>Physical Review B</i>, vol. 104, no. 2, 024430, American Physical Society, 2021, doi:<a href=\"https://doi.org/10.1103/physrevb.104.024430\">10.1103/physrevb.104.024430</a>."},"title":"Interplay between friction and spin-orbit coupling as a source of spin polarization","day":"01","author":[{"first_name":"Artem","full_name":"Volosniev, Artem","last_name":"Volosniev","id":"37D278BC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-0393-5525"},{"last_name":"Alpern","full_name":"Alpern, Hen","first_name":"Hen"},{"last_name":"Paltiel","full_name":"Paltiel, Yossi","first_name":"Yossi"},{"first_name":"Oded","full_name":"Millo, Oded","last_name":"Millo"},{"full_name":"Lemeshko, Mikhail","first_name":"Mikhail","last_name":"Lemeshko","orcid":"0000-0002-6990-7802","id":"37CB05FA-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Ghazaryan","first_name":"Areg","full_name":"Ghazaryan, Areg","orcid":"0000-0001-9666-3543","id":"4AF46FD6-F248-11E8-B48F-1D18A9856A87"}],"type":"journal_article","publisher":"American Physical Society","isi":1,"department":[{"_id":"MiLe"}],"quality_controlled":"1","publication":"Physical Review B","intvolume":"       104","status":"public","month":"07","date_created":"2021-08-04T15:05:32Z","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","date_updated":"2023-08-10T14:27:07Z","external_id":{"isi":["000678780800003"],"arxiv":["2101.05173"]},"scopus_import":"1","publication_identifier":{"issn":["2469-9950"],"eissn":["2469-9969"]},"article_type":"original","year":"2021","oa_version":"Preprint","publication_status":"published","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/2101.05173"}],"oa":1,"volume":104,"arxiv":1,"issue":"2","article_processing_charge":"No","article_number":"024430","_id":"9770","abstract":[{"lang":"eng","text":"We study an effective one-dimensional quantum model that includes friction and spin-orbit coupling (SOC), and show that the model exhibits spin polarization when both terms are finite. Most important, strong spin polarization can be observed even for moderate SOC, provided that the friction is strong. Our findings might help to explain the pronounced effect of chirality on spin distribution and transport in chiral molecules. In particular, our model implies static magnetic properties of a chiral molecule, which lead to Shiba-like states when a molecule is placed on a superconductor, in accordance with recent experimental data."}],"date_published":"2021-07-01T00:00:00Z"},{"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"volume":12,"file_date_updated":"2021-12-17T11:34:50Z","oa":1,"publication_status":"published","_id":"9778","date_published":"2021-05-18T00:00:00Z","abstract":[{"text":"The hippocampal mossy fiber synapse is a key synapse of the trisynaptic circuit. Post-tetanic potentiation (PTP) is the most powerful form of plasticity at this synaptic connection. It is widely believed that mossy fiber PTP is an entirely presynaptic phenomenon, implying that PTP induction is input-specific, and requires neither activity of multiple inputs nor stimulation of postsynaptic neurons. To directly test cooperativity and associativity, we made paired recordings between single mossy fiber terminals and postsynaptic CA3 pyramidal neurons in rat brain slices. By stimulating non-overlapping mossy fiber inputs converging onto single CA3 neurons, we confirm that PTP is input-specific and non-cooperative. Unexpectedly, mossy fiber PTP exhibits anti-associative induction properties. EPSCs show only minimal PTP after combined pre- and postsynaptic high-frequency stimulation with intact postsynaptic Ca2+ signaling, but marked PTP in the absence of postsynaptic spiking and after suppression of postsynaptic Ca2+ signaling (10 mM EGTA). PTP is largely recovered by inhibitors of voltage-gated R- and L-type Ca2+ channels, group II mGluRs, and vacuolar-type H+-ATPase, suggesting the involvement of retrograde vesicular glutamate signaling. Transsynaptic regulation of PTP extends the repertoire of synaptic computations, implementing a brake on mossy fiber detonation and a “smart teacher” function of hippocampal mossy fiber synapses.","lang":"eng"}],"article_number":"2912","file":[{"date_created":"2021-12-17T11:34:50Z","success":1,"content_type":"application/pdf","relation":"main_file","file_id":"10563","checksum":"6036a8cdae95e1707c2a04d54e325ff4","date_updated":"2021-12-17T11:34:50Z","access_level":"open_access","file_name":"2021_NatureCommunications_Vandael.pdf","file_size":3108845,"creator":"kschuh"}],"article_processing_charge":"No","issue":"1","acknowledged_ssus":[{"_id":"SSU"}],"publication_identifier":{"issn":["2041-1723"]},"scopus_import":"1","external_id":{"isi":["000655481800014"]},"date_updated":"2023-08-10T14:16:16Z","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","has_accepted_license":"1","oa_version":"Published Version","year":"2021","article_type":"original","status":"public","intvolume":"        12","publication":"Nature Communications","department":[{"_id":"PeJo"}],"quality_controlled":"1","isi":1,"publisher":"Springer","date_created":"2021-08-06T07:22:55Z","month":"05","ddc":["570"],"doi":"10.1038/s41467-021-23153-5","keyword":["general physics and astronomy","general biochemistry","genetics and molecular biology","general chemistry"],"language":[{"iso":"eng"}],"related_material":{"link":[{"url":"https://ist.ac.at/en/news/synaptic-transmission-not-a-one-way-street/","description":"News on IST Homepage","relation":"press_release"}]},"project":[{"_id":"25B7EB9E-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"Biophysics and circuit function of a giant cortical glumatergic synapse","grant_number":"692692"},{"call_identifier":"FWF","_id":"25C5A090-B435-11E9-9278-68D0E5697425","name":"The Wittgenstein Prize","grant_number":"Z00312"}],"acknowledgement":"We thank Drs. Carolina Borges-Merjane and Jose Guzman for critically reading the manuscript, and Pablo Castillo for discussions. We are grateful to Alois Schlögl for help with analysis, Florian Marr for excellent technical assistance and cell reconstruction, Christina Altmutter for technical help, Eleftheria Kralli-Beller for manuscript editing, and the Scientific Service Units of IST Austria for support. This project received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement No 692692) and the Fond zur Förderung der Wissenschaftlichen Forschung (Z 312-B27, Wittgenstein award), both to P.J.","type":"journal_article","author":[{"last_name":"Vandael","full_name":"Vandael, David H","first_name":"David H","orcid":"0000-0001-7577-1676","id":"3AE48E0A-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0003-0408-6094","id":"3337E116-F248-11E8-B48F-1D18A9856A87","first_name":"Yuji","full_name":"Okamoto, Yuji","last_name":"Okamoto"},{"id":"353C1B58-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5001-4804","full_name":"Jonas, Peter M","first_name":"Peter M","last_name":"Jonas"}],"day":"18","title":"Transsynaptic modulation of presynaptic short-term plasticity in hippocampal mossy fiber synapses","citation":{"mla":"Vandael, David H., et al. “Transsynaptic Modulation of Presynaptic Short-Term Plasticity in Hippocampal Mossy Fiber Synapses.” <i>Nature Communications</i>, vol. 12, no. 1, 2912, Springer, 2021, doi:<a href=\"https://doi.org/10.1038/s41467-021-23153-5\">10.1038/s41467-021-23153-5</a>.","chicago":"Vandael, David H, Yuji Okamoto, and Peter M Jonas. “Transsynaptic Modulation of Presynaptic Short-Term Plasticity in Hippocampal Mossy Fiber Synapses.” <i>Nature Communications</i>. Springer, 2021. <a href=\"https://doi.org/10.1038/s41467-021-23153-5\">https://doi.org/10.1038/s41467-021-23153-5</a>.","ieee":"D. H. Vandael, Y. Okamoto, and P. M. Jonas, “Transsynaptic modulation of presynaptic short-term plasticity in hippocampal mossy fiber synapses,” <i>Nature Communications</i>, vol. 12, no. 1. Springer, 2021.","ista":"Vandael DH, Okamoto Y, Jonas PM. 2021. Transsynaptic modulation of presynaptic short-term plasticity in hippocampal mossy fiber synapses. Nature Communications. 12(1), 2912.","ama":"Vandael DH, Okamoto Y, Jonas PM. Transsynaptic modulation of presynaptic short-term plasticity in hippocampal mossy fiber synapses. <i>Nature Communications</i>. 2021;12(1). doi:<a href=\"https://doi.org/10.1038/s41467-021-23153-5\">10.1038/s41467-021-23153-5</a>","apa":"Vandael, D. H., Okamoto, Y., &#38; Jonas, P. M. (2021). Transsynaptic modulation of presynaptic short-term plasticity in hippocampal mossy fiber synapses. <i>Nature Communications</i>. Springer. <a href=\"https://doi.org/10.1038/s41467-021-23153-5\">https://doi.org/10.1038/s41467-021-23153-5</a>","short":"D.H. Vandael, Y. Okamoto, P.M. Jonas, Nature Communications 12 (2021)."},"ec_funded":1},{"article_number":"2101.12566","_id":"9787","abstract":[{"lang":"eng","text":"We investigate the Fröhlich polaron model on a three-dimensional torus, and give a proof of the second-order quantum corrections to its ground-state energy in the strong-coupling limit. Compared to previous work in the confined case, the translational symmetry (and its breaking in the Pekar approximation) makes the analysis substantially more challenging."}],"date_published":"2021-02-01T00:00:00Z","arxiv":1,"article_processing_charge":"No","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"publication_status":"submitted","main_file_link":[{"url":"https://arxiv.org/abs/2101.12566","open_access":"1"}],"oa":1,"oa_version":"Preprint","year":"2021","has_accepted_license":"1","external_id":{"arxiv":["2101.12566"]},"user_id":"D865714E-FA4E-11E9-B85B-F5C5E5697425","date_updated":"2023-09-07T13:30:10Z","month":"02","date_created":"2021-08-06T08:25:57Z","publication":"arXiv","department":[{"_id":"RoSe"}],"status":"public","day":"01","author":[{"last_name":"Feliciangeli","full_name":"Feliciangeli, Dario","first_name":"Dario","id":"41A639AA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-0754-8530"},{"orcid":"0000-0002-6781-0521","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","last_name":"Seiringer","first_name":"Robert","full_name":"Seiringer, Robert"}],"type":"preprint","citation":{"short":"D. Feliciangeli, R. Seiringer, ArXiv (n.d.).","apa":"Feliciangeli, D., &#38; Seiringer, R. (n.d.). The strongly coupled polaron on the torus: Quantum corrections to the Pekar asymptotics. <i>arXiv</i>.","ama":"Feliciangeli D, Seiringer R. The strongly coupled polaron on the torus: Quantum corrections to the Pekar asymptotics. <i>arXiv</i>.","ista":"Feliciangeli D, Seiringer R. The strongly coupled polaron on the torus: Quantum corrections to the Pekar asymptotics. arXiv, 2101.12566.","ieee":"D. Feliciangeli and R. Seiringer, “The strongly coupled polaron on the torus: Quantum corrections to the Pekar asymptotics,” <i>arXiv</i>. .","chicago":"Feliciangeli, Dario, and Robert Seiringer. “The Strongly Coupled Polaron on the Torus: Quantum Corrections to the Pekar Asymptotics.” <i>ArXiv</i>, n.d.","mla":"Feliciangeli, Dario, and Robert Seiringer. “The Strongly Coupled Polaron on the Torus: Quantum Corrections to the Pekar Asymptotics.” <i>ArXiv</i>, 2101.12566."},"ec_funded":1,"title":"The strongly coupled polaron on the torus: Quantum corrections to the Pekar asymptotics","language":[{"iso":"eng"}],"ddc":["510"],"related_material":{"record":[{"relation":"later_version","id":"10224","status":"public"},{"id":"9733","relation":"dissertation_contains","status":"public"}]},"project":[{"_id":"25C6DC12-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"Analysis of quantum many-body systems","grant_number":"694227"}],"acknowledgement":"Funding from the European Union’s Horizon 2020 research and innovation programme under the ERC grant agreement No 694227 is gratefully acknowledged. We would also like to thank Rupert Frank for many helpful discussions, especially related to the Gross coordinate transformation defined in Def. 4.1.\r\n"},{"article_processing_charge":"No","arxiv":1,"_id":"9791","date_published":"2021-07-08T00:00:00Z","abstract":[{"text":"We provide a definition of the effective mass for the classical polaron described by the Landau-Pekar equations. It is based on a novel variational principle, minimizing the energy functional over states with given (initial) velocity. The resulting formula for the polaron's effective mass agrees with the prediction by Landau and Pekar.","lang":"eng"}],"date_created":"2021-08-06T08:49:45Z","month":"07","article_number":"2107.03720 ","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/2107.03720"}],"oa":1,"publication_status":"submitted","status":"public","publication":"arXiv","department":[{"_id":"RoSe"}],"title":"The effective mass problem for the Landau-Pekar equations","citation":{"ieee":"D. Feliciangeli, S. A. E. Rademacher, and R. Seiringer, “The effective mass problem for the Landau-Pekar equations,” <i>arXiv</i>. .","ista":"Feliciangeli D, Rademacher SAE, Seiringer R. The effective mass problem for the Landau-Pekar equations. arXiv, 2107.03720.","chicago":"Feliciangeli, Dario, Simone Anna Elvira Rademacher, and Robert Seiringer. “The Effective Mass Problem for the Landau-Pekar Equations.” <i>ArXiv</i>, n.d.","mla":"Feliciangeli, Dario, et al. “The Effective Mass Problem for the Landau-Pekar Equations.” <i>ArXiv</i>, 2107.03720.","short":"D. Feliciangeli, S.A.E. Rademacher, R. Seiringer, ArXiv (n.d.).","apa":"Feliciangeli, D., Rademacher, S. A. E., &#38; Seiringer, R. (n.d.). The effective mass problem for the Landau-Pekar equations. <i>arXiv</i>.","ama":"Feliciangeli D, Rademacher SAE, Seiringer R. The effective mass problem for the Landau-Pekar equations. <i>arXiv</i>."},"ec_funded":1,"author":[{"id":"41A639AA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-0754-8530","full_name":"Feliciangeli, Dario","first_name":"Dario","last_name":"Feliciangeli"},{"orcid":"0000-0001-5059-4466","id":"856966FE-A408-11E9-977E-802DE6697425","last_name":"Rademacher","first_name":"Simone Anna Elvira","full_name":"Rademacher, Simone Anna Elvira"},{"last_name":"Seiringer","full_name":"Seiringer, Robert","first_name":"Robert","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6781-0521"}],"type":"preprint","oa_version":"Preprint","year":"2021","day":"08","project":[{"_id":"260C2330-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"754411","name":"ISTplus - Postdoctoral Fellowships"},{"_id":"25C6DC12-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"Analysis of quantum many-body systems","grant_number":"694227"}],"related_material":{"record":[{"status":"public","relation":"later_version","id":"10755"},{"id":"9733","relation":"dissertation_contains","status":"public"}]},"acknowledgement":"We thank Herbert Spohn for helpful comments. Funding from the European Union’s Horizon 2020 research and innovation programme under the ERC grant agreement No. 694227 (D.F. and R.S.) and under the Marie Skłodowska-Curie Grant Agreement No. 754411 (S.R.) is gratefully acknowledged..","ddc":["510"],"external_id":{"arxiv":["2107.03720"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2024-03-06T12:30:45Z","language":[{"iso":"eng"}]},{"arxiv":1,"article_processing_charge":"No","article_number":"2106.11217","_id":"9792","date_published":"2021-07-21T00:00:00Z","abstract":[{"lang":"eng","text":"This paper establishes new connections between many-body quantum systems, One-body Reduced Density Matrices Functional Theory (1RDMFT) and Optimal Transport (OT), by interpreting the problem of computing the ground-state energy of a finite dimensional composite quantum system at positive temperature as a non-commutative entropy regularized Optimal Transport problem. We develop a new approach to fully characterize the dual-primal solutions in such non-commutative setting. The mathematical formalism is particularly relevant in quantum chemistry: numerical realizations of the many-electron ground state energy can be computed via a non-commutative version of Sinkhorn algorithm. Our approach allows to prove convergence and robustness of this algorithm, which, to our best knowledge, were unknown even in the two marginal case. Our methods are based on careful a priori estimates in the dual problem, which we believe to be of independent interest. Finally, the above results are extended in 1RDMFT setting, where bosonic or fermionic symmetry conditions are enforced on the problem."}],"publication_status":"submitted","oa":1,"main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2106.11217","open_access":"1"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"oa_version":"Preprint","has_accepted_license":"1","year":"2021","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2023-11-14T13:21:01Z","external_id":{"arxiv":["2106.11217"]},"month":"07","date_created":"2021-08-06T09:07:12Z","department":[{"_id":"RoSe"},{"_id":"JaMa"}],"publication":"arXiv","status":"public","ec_funded":1,"citation":{"ama":"Feliciangeli D, Gerolin A, Portinale L. A non-commutative entropic optimal transport approach to quantum composite systems at positive temperature. <i>arXiv</i>. doi:<a href=\"https://doi.org/10.48550/arXiv.2106.11217\">10.48550/arXiv.2106.11217</a>","apa":"Feliciangeli, D., Gerolin, A., &#38; Portinale, L. (n.d.). A non-commutative entropic optimal transport approach to quantum composite systems at positive temperature. <i>arXiv</i>. <a href=\"https://doi.org/10.48550/arXiv.2106.11217\">https://doi.org/10.48550/arXiv.2106.11217</a>","short":"D. Feliciangeli, A. Gerolin, L. Portinale, ArXiv (n.d.).","mla":"Feliciangeli, Dario, et al. “A Non-Commutative Entropic Optimal Transport Approach to Quantum Composite Systems at Positive Temperature.” <i>ArXiv</i>, 2106.11217, doi:<a href=\"https://doi.org/10.48550/arXiv.2106.11217\">10.48550/arXiv.2106.11217</a>.","chicago":"Feliciangeli, Dario, Augusto Gerolin, and Lorenzo Portinale. “A Non-Commutative Entropic Optimal Transport Approach to Quantum Composite Systems at Positive Temperature.” <i>ArXiv</i>, n.d. <a href=\"https://doi.org/10.48550/arXiv.2106.11217\">https://doi.org/10.48550/arXiv.2106.11217</a>.","ista":"Feliciangeli D, Gerolin A, Portinale L. A non-commutative entropic optimal transport approach to quantum composite systems at positive temperature. arXiv, 2106.11217.","ieee":"D. Feliciangeli, A. Gerolin, and L. Portinale, “A non-commutative entropic optimal transport approach to quantum composite systems at positive temperature,” <i>arXiv</i>. ."},"title":"A non-commutative entropic optimal transport approach to quantum composite systems at positive temperature","day":"21","type":"preprint","author":[{"full_name":"Feliciangeli, Dario","first_name":"Dario","last_name":"Feliciangeli","id":"41A639AA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-0754-8530"},{"first_name":"Augusto","full_name":"Gerolin, Augusto","last_name":"Gerolin"},{"id":"30AD2CBC-F248-11E8-B48F-1D18A9856A87","first_name":"Lorenzo","full_name":"Portinale, Lorenzo","last_name":"Portinale"}],"acknowledgement":"This work started when A.G. was visiting the Erwin Schrödinger Institute and then continued when D.F. and L.P visited the Theoretical Chemistry Department of the Vrije Universiteit Amsterdam. The authors thanks the hospitality of both places and, especially, P. Gori-Giorgi and K. Giesbertz for fruitful discussions and literature suggestions in the early state of the project. Finally, the authors also thanks J. Maas and R. Seiringer for their feedback and useful comments to a first draft of the article.  L.P. acknowledges support by the Austrian Science Fund (FWF), grants No W1245 and NoF65. D.F acknowledges support by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreements No 716117 and No 694227). A.G. acknowledges funding by the European Research Council under H2020/MSCA-IF “OTmeetsDFT” [grant ID: 795942].","project":[{"name":"Analysis of quantum many-body systems","grant_number":"694227","call_identifier":"H2020","_id":"25C6DC12-B435-11E9-9278-68D0E5697425"},{"name":"Optimal Transport and Stochastic Dynamics","grant_number":"716117","_id":"256E75B8-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"},{"_id":"fc31cba2-9c52-11eb-aca3-ff467d239cd2","grant_number":"F6504","name":"Taming Complexity in Partial Differential Systems"}],"related_material":{"record":[{"relation":"dissertation_contains","id":"9733","status":"public"},{"id":"10030","relation":"dissertation_contains","status":"public"},{"id":"12911","relation":"later_version","status":"public"}]},"language":[{"iso":"eng"}],"doi":"10.48550/arXiv.2106.11217","ddc":["510"]},{"publisher":"Elsevier","isi":1,"quality_controlled":"1","department":[{"_id":"SiHi"}],"publication":"Neuron","status":"public","intvolume":"       109","page":"2427-2442.e10","month":"08","date_created":"2021-08-06T09:08:25Z","acknowledgement":"This work was supported by the National Institutes of Health (R01 DA047258 and R01 NS102237 to C.E., F32 NS100392 to K.T.B.) and the Holland-Trice Brain Research Award (to C.E.). K.T.B. was supported by postdoctoral fellowships from the Foerster-Bernstein Family and The Hartwell Foundation. The Hippenmeyer lab was supported by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovations program (725780 LinPro) to S.H. R.E. was supported by Ministerio de Ciencia y Tecnología (RTI2018-093493-B-I00). We thank the Duke Light Microscopy Core Facility, the Duke Transgenic Mouse Facility, Dr. U. Schulte for assistance with proteomic experiments, and Dr. D. Silver for critical review of the manuscript. Cartoon elements of figure panels were created using BioRender.com.","pmid":1,"project":[{"name":"Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development","grant_number":"725780","call_identifier":"H2020","_id":"260018B0-B435-11E9-9278-68D0E5697425"}],"language":[{"iso":"eng"}],"doi":"10.1016/j.neuron.2021.05.025","ec_funded":1,"citation":{"short":"K.T. Baldwin, C.X. Tan, S.T. Strader, C. Jiang, J.T. Savage, X. Elorza-Vidal, X. Contreras, T. Rülicke, S. Hippenmeyer, R. Estévez, R.-R. Ji, C. Eroglu, Neuron 109 (2021) 2427–2442.e10.","ama":"Baldwin KT, Tan CX, Strader ST, et al. HepaCAM controls astrocyte self-organization and coupling. <i>Neuron</i>. 2021;109(15):2427-2442.e10. doi:<a href=\"https://doi.org/10.1016/j.neuron.2021.05.025\">10.1016/j.neuron.2021.05.025</a>","apa":"Baldwin, K. T., Tan, C. X., Strader, S. T., Jiang, C., Savage, J. T., Elorza-Vidal, X., … Eroglu, C. (2021). HepaCAM controls astrocyte self-organization and coupling. <i>Neuron</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.neuron.2021.05.025\">https://doi.org/10.1016/j.neuron.2021.05.025</a>","chicago":"Baldwin, Katherine T., Christabel X. Tan, Samuel T. Strader, Changyu Jiang, Justin T. Savage, Xabier Elorza-Vidal, Ximena Contreras, et al. “HepaCAM Controls Astrocyte Self-Organization and Coupling.” <i>Neuron</i>. Elsevier, 2021. <a href=\"https://doi.org/10.1016/j.neuron.2021.05.025\">https://doi.org/10.1016/j.neuron.2021.05.025</a>.","ista":"Baldwin KT, Tan CX, Strader ST, Jiang C, Savage JT, Elorza-Vidal X, Contreras X, Rülicke T, Hippenmeyer S, Estévez R, Ji R-R, Eroglu C. 2021. HepaCAM controls astrocyte self-organization and coupling. Neuron. 109(15), 2427–2442.e10.","ieee":"K. T. Baldwin <i>et al.</i>, “HepaCAM controls astrocyte self-organization and coupling,” <i>Neuron</i>, vol. 109, no. 15. Elsevier, p. 2427–2442.e10, 2021.","mla":"Baldwin, Katherine T., et al. “HepaCAM Controls Astrocyte Self-Organization and Coupling.” <i>Neuron</i>, vol. 109, no. 15, Elsevier, 2021, p. 2427–2442.e10, doi:<a href=\"https://doi.org/10.1016/j.neuron.2021.05.025\">10.1016/j.neuron.2021.05.025</a>."},"title":"HepaCAM controls astrocyte self-organization and coupling","day":"04","author":[{"last_name":"Baldwin","first_name":"Katherine T.","full_name":"Baldwin, Katherine T."},{"full_name":"Tan, Christabel X.","first_name":"Christabel X.","last_name":"Tan"},{"full_name":"Strader, Samuel T.","first_name":"Samuel T.","last_name":"Strader"},{"last_name":"Jiang","first_name":"Changyu","full_name":"Jiang, Changyu"},{"first_name":"Justin T.","full_name":"Savage, Justin T.","last_name":"Savage"},{"last_name":"Elorza-Vidal","full_name":"Elorza-Vidal, Xabier","first_name":"Xabier"},{"last_name":"Contreras","full_name":"Contreras, Ximena","first_name":"Ximena","id":"475990FE-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Rülicke, Thomas","first_name":"Thomas","last_name":"Rülicke"},{"orcid":"0000-0003-2279-1061","id":"37B36620-F248-11E8-B48F-1D18A9856A87","first_name":"Simon","full_name":"Hippenmeyer, Simon","last_name":"Hippenmeyer"},{"last_name":"Estévez","full_name":"Estévez, Raúl","first_name":"Raúl"},{"last_name":"Ji","first_name":"Ru-Rong","full_name":"Ji, Ru-Rong"},{"last_name":"Eroglu","first_name":"Cagla","full_name":"Eroglu, Cagla"}],"type":"journal_article","publication_status":"published","oa":1,"main_file_link":[{"url":"https://doi.org/10.1016/j.neuron.2021.05.025","open_access":"1"}],"volume":109,"issue":"15","article_processing_charge":"No","_id":"9793","abstract":[{"text":"Astrocytes extensively infiltrate the neuropil to regulate critical aspects of synaptic development and function. This process is regulated by transcellular interactions between astrocytes and neurons via cell adhesion molecules. How astrocytes coordinate developmental processes among one another to parse out the synaptic neuropil and form non-overlapping territories is unknown. Here we identify a molecular mechanism regulating astrocyte-astrocyte interactions during development to coordinate astrocyte morphogenesis and gap junction coupling. We show that hepaCAM, a disease-linked, astrocyte-enriched cell adhesion molecule, regulates astrocyte competition for territory and morphological complexity in the developing mouse cortex. Furthermore, conditional deletion of Hepacam from developing astrocytes significantly impairs gap junction coupling between astrocytes and disrupts the balance between synaptic excitation and inhibition. Mutations in HEPACAM cause megalencephalic leukoencephalopathy with subcortical cysts in humans. Therefore, our findings suggest that disruption of astrocyte self-organization mechanisms could be an underlying cause of neural pathology.","lang":"eng"}],"date_published":"2021-08-04T00:00:00Z","date_updated":"2023-09-27T07:46:09Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","external_id":{"isi":["000692851900010"],"pmid":["34171291"]},"scopus_import":"1","publication_identifier":{"issn":["0896-6273"],"eissn":["1097-4199"]},"article_type":"original","year":"2021","oa_version":"Published Version"}]