@article{8447,
  abstract     = {Solid-state NMR spectroscopy can provide site-resolved information about protein dynamics over many time scales. Here we combine protein deuteration, fast magic-angle spinning (~45–60 kHz) and proton detection to study dynamics of ubiquitin in microcrystals, and in particular a mutant in a region that undergoes microsecond motions in a β-turn region in the wild-type protein. We use 15N R1ρ relaxation measurements as a function of the radio-frequency (RF) field strength, i.e. relaxation dispersion, to probe how the G53A mutation alters these dynamics. We report a population-inversion of conformational states: the conformation that in the wild-type protein is populated only sparsely becomes the predominant state. We furthermore explore the potential to use amide-1H R1ρ relaxation to obtain insight into dynamics. We show that while quantitative interpretation of 1H relaxation remains beyond reach under the experimental conditions, due to coherent contributions to decay, one may extract qualitative information about flexibility.},
  author       = {Gauto, Diego F. and Hessel, Audrey and Rovó, Petra and Kurauskas, Vilius and Linser, Rasmus and Schanda, Paul},
  issn         = {0926-2040},
  journal      = {Solid State Nuclear Magnetic Resonance},
  keywords     = {Nuclear and High Energy Physics, Instrumentation, General Chemistry, Radiation},
  number       = {10},
  pages        = {86--95},
  publisher    = {Elsevier},
  title        = {{Protein conformational dynamics studied by 15N and 1HR1ρ relaxation dispersion: Application to wild-type and G53A ubiquitin crystals}},
  doi          = {10.1016/j.ssnmr.2017.04.002},
  volume       = {87},
  year         = {2017},
}

@article{8448,
  abstract     = {We present an improved fast mixing device based on the rapid mixing of two solutions inside the NMR probe, as originally proposed by Hore and coworkers (J. Am. Chem. Soc. 125 (2003) 12484–12492). Such a device is important for off-equilibrium studies of molecular kinetics by multidimensional real-time NMR spectrsocopy. The novelty of this device is that it allows removing the injector from the NMR detection volume after mixing, and thus provides good magnetic field homogeneity independently of the initial sample volume placed in the NMR probe. The apparatus is simple to build, inexpensive, and can be used without any hardware modification on any type of liquid-state NMR spectrometer. We demonstrate the performance of our fast mixing device in terms of improved magnetic field homogeneity, and show an application to the study of protein folding and the structural characterization of transiently populated folding intermediates.},
  author       = {Franco, Rémi and Favier, Adrien and Schanda, Paul and Brutscher, Bernhard},
  issn         = {1090-7807},
  journal      = {Journal of Magnetic Resonance},
  keywords     = {Nuclear and High Energy Physics, Biophysics, Biochemistry, Condensed Matter Physics},
  number       = {8},
  pages        = {125--129},
  publisher    = {Elsevier},
  title        = {{Optimized fast mixing device for real-time NMR applications}},
  doi          = {10.1016/j.jmr.2017.05.016},
  volume       = {281},
  year         = {2017},
}

@article{8449,
  abstract     = {Ensuring the correct folding of RNA molecules in the cell is of major importance for a large variety of biological functions. Therefore, chaperone proteins that assist RNA in adopting their functionally active states are abundant in all living organisms. An important feature of RNA chaperone proteins is that they do not require an external energy source to perform their activity, and that they interact transiently and non-specifically with their RNA targets. So far, little is known about the mechanistic details of the RNA chaperone activity of these proteins. Prominent examples of RNA chaperones are bacterial cold shock proteins (Csp) that have been reported to bind single-stranded RNA and DNA. Here, we have used advanced NMR spectroscopy techniques to investigate at atomic resolution the RNA-melting activity of CspA, the major cold shock protein of Escherichia coli, upon binding to different RNA hairpins. Real-time NMR provides detailed information on the folding kinetics and folding pathways. Finally, comparison of wild-type CspA with single-point mutants and small peptides yields insights into the complementary roles of aromatic and positively charged amino-acid side chains for the RNA chaperone activity of the protein.},
  author       = {Rennella, Enrico and Sára, Tomáš and Juen, Michael and Wunderlich, Christoph and Imbert, Lionel and Solyom, Zsofia and Favier, Adrien and Ayala, Isabel and Weinhäupl, Katharina and Schanda, Paul and Konrat, Robert and Kreutz, Christoph and Brutscher, Bernhard},
  issn         = {0305-1048},
  journal      = {Nucleic Acids Research},
  number       = {7},
  pages        = {4255--4268},
  publisher    = {Oxford University Press},
  title        = {{RNA binding and chaperone activity of the E.coli cold-shock protein CspA}},
  doi          = {10.1093/nar/gkx044},
  volume       = {45},
  year         = {2017},
}

@inbook{8450,
  abstract     = {Methyl groups are very useful probes of structure, dynamics, and interactions in protein NMR spectroscopy. In particular, methyl-directed experiments provide high sensitivity even in very large proteins, such as membrane proteins in a membrane-mimicking environment. In this chapter, we discuss the approach for labeling methyl groups in E. coli-based protein expression, as exemplified with the mitochondrial carrier GGC.},
  author       = {Kurauskas, Vilius and Schanda, Paul and Sounier, Remy},
  booktitle    = {Membrane protein structure and function characterization},
  isbn         = {9781493971497},
  issn         = {1064-3745},
  pages        = {109--123},
  publisher    = {Springer Nature},
  title        = {{Methyl-specific isotope labeling strategies for NMR studies of membrane proteins}},
  doi          = {10.1007/978-1-4939-7151-0_6},
  volume       = {1635},
  year         = {2017},
}

@article{8451,
  abstract     = {The structure, dynamics, and function of membrane proteins are intimately linked to the properties of the membrane environment in which the proteins are embedded. For structural and biophysical characterization, membrane proteins generally need to be extracted from the membrane and reconstituted in a suitable membrane‐mimicking environment. Ensuring functional and structural integrity in these environments is often a major concern. The styrene/maleic acid co‐polymer has recently been shown to be able to extract lipid/membrane protein patches directly from native membranes to form nanosize discoidal proteolipid particles, also referred to as native nanodiscs. In this work, we show that high‐resolution solid‐state NMR spectra can be obtained from an integral membrane protein in native nanodiscs, as exemplified by the 2×34 kDa bacterial cation diffusion facilitator CzcD.},
  author       = {Bersch, Beate and Dörr, Jonas M. and Hessel, Audrey and Killian, J. Antoinette and Schanda, Paul},
  issn         = {1433-7851},
  journal      = {Angewandte Chemie International Edition},
  number       = {9},
  pages        = {2508--2512},
  publisher    = {Wiley},
  title        = {{Proton-detected solid-state NMR spectroscopy of a Zinc diffusion facilitator protein in native nanodiscs}},
  doi          = {10.1002/anie.201610441},
  volume       = {56},
  year         = {2017},
}

@article{9065,
  abstract     = {Magnetic anisotropy in strontium iridate (Sr2IrO4) is found to be large because of the strong spin-orbit interactions. In our work, we studied the in-plane magnetic anisotropy of Sr2IrO4 and traced the anisotropic exchange interactions between the isospins in the crystal. The magnetic-field-dependent torque τ(H) showed a prominent transition from the canted antiferromagnetic state to the weak ferromagnetic (WFM) state. A comprehensive analysis was conducted to examine the isotropic and anisotropic regimes and probe the easy magnetization axis along the a b plane. The angle-dependent torque τ(θ) revealed a deviation from the sinusoidal behavior, and small differences in hysteresis were observed around 0° and 90° in the low-magnetic-field regime. This indicates that the orientation of the easy axis of the FM component is along the b axis, where the antiferromagnetic to WFM spin-flop transition occurs. We compared the coefficients of the magnetic susceptibility tensors and captured the anisotropy of the material. The in-plane τ(θ) revealed a tendency toward isotropic behavior for fields with values above the field value of the WFM transition.},
  author       = {Nauman, Muhammad and Hong, Yunjeong and Hussain, Tayyaba and Seo, M. S. and Park, S. Y. and Lee, N. and Choi, Y. J. and Kang, Woun and Jo, Younjung},
  issn         = {2469-9950},
  journal      = {Physical Review B},
  number       = {15},
  publisher    = {American Physical Society},
  title        = {{In-plane magnetic anisotropy in strontium iridate Sr2IrO4}},
  doi          = {10.1103/physrevb.96.155102},
  volume       = {96},
  year         = {2017},
}

@article{909,
  abstract     = {We study the lengths of curves passing through a fixed number of points on the boundary of a convex shape in the plane. We show that, for any convex shape K, there exist four points on the boundary of K such that the length of any curve passing through these points is at least half of the perimeter of K. It is also shown that the same statement does not remain valid with the additional constraint that the points are extreme points of K. Moreover, the factor &amp;#xbd; cannot be achieved with any fixed number of extreme points. We conclude the paper with a few other inequalities related to the perimeter of a convex shape.},
  author       = {Akopyan, Arseniy and Vysotsky, Vladislav},
  issn         = {00029890},
  journal      = {The American Mathematical Monthly},
  number       = {7},
  pages        = {588 -- 596},
  publisher    = {Mathematical Association of America},
  title        = {{On the lengths of curves passing through boundary points of a planar convex shape}},
  doi          = {10.4169/amer.math.monthly.124.7.588},
  volume       = {124},
  year         = {2017},
}

@article{910,
  abstract     = {Frequency-independent selection is generally considered as a force that acts to reduce the genetic variation in evolving populations, yet rigorous arguments for this idea are scarce. When selection fluctuates in time, it is unclear whether frequency-independent selection may maintain genetic polymorphism without invoking additional mechanisms. We show that constant frequency-independent selection with arbitrary epistasis on a well-mixed haploid population eliminates genetic variation if we assume linkage equilibrium between alleles. To this end, we introduce the notion of frequency-independent selection at the level of alleles, which is sufficient to prove our claim and contains the notion of frequency-independent selection on haploids. When selection and recombination are weak but of the same order, there may be strong linkage disequilibrium; numerical calculations show that stable equilibria are highly unlikely. Using the example of a diallelic two-locus model, we then demonstrate that frequency-independent selection that fluctuates in time can maintain stable polymorphism if linkage disequilibrium changes its sign periodically. We put our findings in the context of results from the existing literature and point out those scenarios in which the possible role of frequency-independent selection in maintaining genetic variation remains unclear.
},
  author       = {Novak, Sebastian and Barton, Nicholas H},
  journal      = {Genetics},
  number       = {2},
  pages        = {653 -- 668},
  publisher    = {Genetics Society of America},
  title        = {{When does frequency-independent selection maintain genetic variation?}},
  doi          = {10.1534/genetics.117.300129},
  volume       = {207},
  year         = {2017},
}

@inproceedings{911,
  abstract     = {We develop a probabilistic technique for colorizing grayscale natural images. In light of the intrinsic uncertainty of this task, the proposed probabilistic framework has numerous desirable properties. In particular, our model is able to produce multiple plausible and vivid colorizations for a given grayscale image and is one of the first colorization models to provide a proper stochastic sampling scheme. Moreover, our training procedure is supported by a rigorous theoretical framework that does not require any ad hoc heuristics and allows for efficient modeling and learning of the joint pixel color distribution.We demonstrate strong quantitative and qualitative experimental results on the CIFAR-10 dataset and the challenging ILSVRC 2012 dataset.},
  author       = {Royer, Amélie and Kolesnikov, Alexander and Lampert, Christoph},
  location     = {London, United Kingdom},
  pages        = {85.1--85.12},
  publisher    = {BMVA Press},
  title        = {{Probabilistic image colorization}},
  doi          = {10.5244/c.31.85},
  year         = {2017},
}

@article{912,
  abstract     = {We consider a many-body system of fermionic atoms interacting via a local pair potential and subject to an external potential within the framework of Bardeen-Cooper-Schrieffer (BCS) theory. We measure the free energy of the whole sample with respect to the free energy of a reference state which allows us to define a BCS functional with boundary conditions at infinity. Our main result is a lower bound for this energy functional in terms of expressions that typically appear in Ginzburg-Landau functionals.
},
  author       = {Deuchert, Andreas},
  issn         = {00222488},
  journal      = { Journal of Mathematical Physics},
  number       = {8},
  publisher    = {AIP Publishing},
  title        = {{A lower bound for the BCS functional with boundary conditions at infinity}},
  doi          = {10.1063/1.4996580},
  volume       = {58},
  year         = {2017},
}

@article{9137,
  abstract     = {Pools of air cooled by partial rain evaporation span up to several hundreds of kilometers in nature and typically last less than 1 day, ultimately losing their identity to the large-scale flow. These fundamentally differ in character from the radiatively-driven dry pools defining convective aggregation. Advancement in remote sensing and in computer capabilities has promoted exploration of how precipitation-induced cold pool processes modify the convective spectrum and life cycle. This contribution surveys current understanding of such cold pools over the tropical and subtropical oceans. In shallow convection with low rain rates, the cold pools moisten, preserving the near-surface equivalent potential temperature or increasing it if the surface moisture fluxes cannot ventilate beyond the new surface layer; both conditions indicate downdraft origin air from within the boundary layer. When rain rates exceed ∼ 2 mm h−1, convective-scale downdrafts can bring down drier air of lower equivalent potential temperature from above the boundary layer. The resulting density currents facilitate the lifting of locally thermodynamically favorable air and can impose an arc-shaped mesoscale cloud organization. This organization allows clouds capable of reaching 4–5 km within otherwise dry environments. These are more commonly observed in the northern hemisphere trade wind regime, where the flow to the intertropical convergence zone is unimpeded by the equator. Their near-surface air properties share much with those shown from cold pools sampled in the equatorial Indian Ocean. Cold pools are most effective at influencing the mesoscale organization when the atmosphere is moist in the lower free troposphere and dry above, suggesting an optimal range of water vapor paths. Outstanding questions on the relationship between cold pools, their accompanying moisture distribution and cloud cover are detailed further. Near-surface water vapor rings are documented in one model inside but near the cold pool edge; these are not consistent with observations, but do improve with smaller horizontal grid spacings.},
  author       = {Zuidema, Paquita and Torri, Giuseppe and Muller, Caroline J and Chandra, Arunchandra},
  issn         = {0169-3298},
  journal      = {Surveys in Geophysics},
  keywords     = {Geochemistry and Petrology, Geophysics},
  number       = {6},
  pages        = {1283--1305},
  publisher    = {Springer Nature},
  title        = {{A survey of precipitation-induced atmospheric cold pools over oceans and their interactions with the larger-scale environment}},
  doi          = {10.1007/s10712-017-9447-x},
  volume       = {38},
  year         = {2017},
}

@article{9138,
  abstract     = {Convective self-aggregation, the spontaneous organization of initially scattered convection into isolated convective clusters despite spatially homogeneous boundary conditions and forcing, was first recognized and studied in idealized numerical simulations. While there is a rich history of observational work on convective clustering and organization, there have been only a few studies that have analyzed observations to look specifically for processes related to self-aggregation in models. Here we review observational work in both of these categories and motivate the need for more of this work. We acknowledge that self-aggregation may appear to be far-removed from observed convective organization in terms of time scales, initial conditions, initiation processes, and mean state extremes, but we argue that these differences vary greatly across the diverse range of model simulations in the literature and that these comparisons are already offering important insights into real tropical phenomena. Some preliminary new findings are presented, including results showing that a self-aggregation simulation with square geometry has too broad distribution of humidity and is too dry in the driest regions when compared with radiosonde records from Nauru, while an elongated channel simulation has realistic representations of atmospheric humidity and its variability. We discuss recent work increasing our understanding of how organized convection and climate change may interact, and how model discrepancies related to this question are prompting interest in observational comparisons. We also propose possible future directions for observational work related to convective aggregation, including novel satellite approaches and a ground-based observational network.},
  author       = {Holloway, Christopher E. and Wing, Allison A. and Bony, Sandrine and Muller, Caroline J and Masunaga, Hirohiko and L’Ecuyer, Tristan S. and Turner, David D. and Zuidema, Paquita},
  issn         = {0169-3298},
  journal      = {Surveys in Geophysics},
  keywords     = {Geochemistry and Petrology, Geophysics},
  number       = {6},
  pages        = {1199--1236},
  publisher    = {Springer Nature},
  title        = {{Observing convective aggregation}},
  doi          = {10.1007/s10712-017-9419-1},
  volume       = {38},
  year         = {2017},
}

@article{9139,
  abstract     = {Organized convection in the tropics occurs across a range of spatial and temporal scales and strongly influences cloud cover and humidity. One mode of organization found is “self-aggregation,” in which moist convection spontaneously organizes into one or several isolated clusters despite spatially homogeneous boundary conditions and forcing. Self-aggregation is driven by interactions between clouds, moisture, radiation, surface fluxes, and circulation, and occurs in a wide variety of idealized simulations of radiative–convective equilibrium. Here we provide a review of convective self-aggregation in numerical simulations, including its character, causes, and effects. We describe the evolution of self-aggregation including its time and length scales and the physical mechanisms leading to its triggering and maintenance, and we also discuss possible links to climate and climate change.},
  author       = {Wing, Allison A. and Emanuel, Kerry and Holloway, Christopher E. and Muller, Caroline J},
  issn         = {0169-3298},
  journal      = {Surveys in Geophysics},
  keywords     = {Geochemistry and Petrology, Geophysics},
  number       = {6},
  pages        = {1173--1197},
  publisher    = {Springer Nature},
  title        = {{Convective self-aggregation in numerical simulations: A review}},
  doi          = {10.1007/s10712-017-9408-4},
  volume       = {38},
  year         = {2017},
}

@article{914,
  abstract     = {Infections with potentially lethal pathogens may negatively affect an individual’s lifespan and decrease its reproductive value. The terminal investment hypothesis predicts that individuals faced with a reduced survival should invest more into reproduction instead of maintenance and growth. Several studies suggest that individuals are indeed able to estimate their body condition and to increase their reproductive effort with approaching death, while other studies gave ambiguous results. We investigate whether queens of a perennial social insect (ant) are able to boost their reproduction following infection with an obligate killing pathogen. Social insect queens are special with regard to reproduction and aging, as they outlive conspecific non-reproductive workers. Moreover, in the ant Cardiocondyla obscurior, fecundity increases with queen age. However, it remained unclear whether this reflects negative reproductive senescence or terminal investment in response to approaching death. Here, we test whether queens of C. obscurior react to infection with the entomopathogenic fungus Metarhizium brunneum by an increased egg-laying rate. We show that a fungal infection triggers a reinforced investment in reproduction in queens. This adjustment of the reproductive rate by ant queens is consistent with predictions of the terminal investment hypothesis and is reported for the first time in a social insect.},
  author       = {Giehr, Julia and Grasse, Anna V and Cremer, Sylvia and Heinze, Jürgen and Schrempf, Alexandra},
  issn         = {20545703},
  journal      = {Royal Society Open Science},
  number       = {7},
  publisher    = {Royal Society, The},
  title        = {{Ant queens increase their reproductive efforts after pathogen infection}},
  doi          = {10.1098/rsos.170547},
  volume       = {4},
  year         = {2017},
}

@inproceedings{915,
  abstract     = {We propose a dual decomposition and linear program relaxation of the NP-hard minimum cost multicut problem. Unlike other polyhedral relaxations of the multicut polytope, it is amenable to efficient optimization by message passing. Like other polyhedral relaxations, it can be tightened efficiently by cutting planes.  We define an algorithm that alternates between message passing and efficient separation of cycle- and odd-wheel inequalities. This algorithm is more efficient than state-of-the-art algorithms based on linear programming, including algorithms written in the framework of leading commercial software, as we show in experiments with large instances of the problem from applications in computer vision, biomedical image analysis and data mining.},
  author       = {Swoboda, Paul and Andres, Bjoern},
  isbn         = {978-153860457-1},
  location     = {Honolulu, HA, United States},
  pages        = {4990--4999},
  publisher    = {IEEE},
  title        = {{A message passing algorithm for the minimum cost multicut problem}},
  doi          = {10.1109/CVPR.2017.530},
  volume       = {2017},
  year         = {2017},
}

@article{9152,
  abstract     = {Previous numerical studies of the dissipation of internal tides in idealized settings suggest the existence of a critical latitude (~29°) where dissipation is enhanced. But observations only indicate a modest enhancement at this latitude. To resolve this difference between observational and numerical results, the authors study the latitudinal dependence of internal tides’ dissipation in more realistic conditions. In particular, the ocean is not a quiescent medium; the presence of large-scale currents or mesoscale eddies can impact the propagation and dissipation of internal tides. This paper investigates the impact of a weak background mean current in numerical simulations. The authors focus on the local dissipation of high spatial mode internal waves near their generation site. The vertical profile of dissipation and its variation with latitude without the mean current are consistent with earlier studies. But adding a weak mean current has a major impact on the latitudinal distribution of dissipation. The peak at the critical latitude disappears, and the dissipation is closer to a constant, albeit with two weak peaks at ~25° and ~35° latitude. This disappearance results from the Doppler shift of the internal tides’ frequency, which hinders the nonlinear transfer of energy to small-scale secondary waves via the parametric subharmonic instability (PSI). The new two weak peaks correspond to the Doppler-shifted critical latitudes of the left- and right-propagating waves. The results are confirmed in simulations with simple sinusoidal topography. Thus, although nonlinear transfers via PSI are efficient at dissipating internal tides, the exact location of the dissipation is sensitive to large-scale oceanic conditions.},
  author       = {Richet, O. and Muller, Caroline J and Chomaz, J.-M.},
  issn         = {0022-3670},
  journal      = {Journal of Physical Oceanography},
  keywords     = {Oceanography},
  number       = {6},
  pages        = {1457--1472},
  publisher    = {American Meteorological Society},
  title        = {{Impact of a mean current on the internal tide energy dissipation at the critical latitude}},
  doi          = {10.1175/jpo-d-16-0197.1},
  volume       = {47},
  year         = {2017},
}

@inproceedings{916,
  abstract     = {We study the quadratic assignment problem, in computer vision also known as graph matching. Two leading solvers for this problem optimize the Lagrange decomposition duals with sub-gradient and dual ascent (also known as message passing) updates. We explore this direction further and propose several additional Lagrangean relaxations of the graph matching problem along with corresponding algorithms, which are all based on a common dual ascent framework. Our extensive empirical evaluation gives several theoretical insights and suggests a new state-of-the-art anytime solver for the considered problem. Our improvement over state-of-the-art is particularly visible on a new dataset with large-scale sparse problem instances containing more than 500 graph nodes each.},
  author       = {Swoboda, Paul and Rother, Carsten and Abu Alhaija, Carsten and Kainmueller, Dagmar and Savchynskyy, Bogdan},
  isbn         = {978-153860457-1},
  location     = {Honolulu, HA, United States},
  pages        = {7062--7071},
  publisher    = {IEEE},
  title        = {{A study of lagrangean decompositions and dual ascent solvers for graph matching}},
  doi          = {10.1109/CVPR.2017.747},
  volume       = {2017},
  year         = {2017},
}

@article{9165,
  abstract     = {Advances in colloidal synthesis allow for the design of particles with controlled patches. This article reviews routes towards colloidal locomotion, where energy is consumed and converted into motion, and its implementation with active patchy particles. A special emphasis is given to phoretic swimmers, where the self-propulsion originates from an interfacial phenomenon, raising experimental challenges and opening up opportunities for particles with controlled anisotropic surface chemistry and novel behaviors.},
  author       = {Aubret, A. and Ramananarivo, S. and Palacci, Jérémie A},
  issn         = {1359-0294},
  journal      = {Current Opinion in Colloid & Interface Science},
  pages        = {81--89},
  publisher    = {Elsevier},
  title        = {{Eppur si muove, and yet it moves: Patchy (phoretic) swimmers}},
  doi          = {10.1016/j.cocis.2017.05.007},
  volume       = {30},
  year         = {2017},
}

@inproceedings{917,
  abstract     = {We  propose  a  general  dual  ascent  framework  for  Lagrangean decomposition of combinatorial problems.  Although methods of this type have shown their efficiency for a number of problems, so far there was no general algorithm applicable to multiple problem types. In this work, we propose such a general algorithm. It depends on several parameters, which can be used to optimize its performance in each particular setting. We demonstrate efficacy of our method on graph matching and multicut problems, where it outperforms state-of-the-art solvers including those based on subgradient optimization and off-the-shelf linear programming solvers.},
  author       = {Swoboda, Paul and Kuske, Jan and Savchynskyy, Bogdan},
  isbn         = {978-153860457-1},
  location     = {Honolulu, HA, United States},
  pages        = {4950--4960},
  publisher    = {IEEE},
  title        = {{A dual ascent framework for Lagrangean decomposition of combinatorial problems}},
  doi          = {10.1109/CVPR.2017.526},
  volume       = {2017},
  year         = {2017},
}

@article{9190,
  abstract     = {<jats:p>Plant meristems carry pools of continuously active stem cells, whose activity is controlled by developmental and environmental signals. After stem cell division, daughter cells that exit the stem cell domain acquire transit amplifying cell identity before they are incorporated into organs and differentiate. In this study, we used an integrated approach to elucidate the role of HECATE (HEC) genes in regulating developmental trajectories of shoot stem cells in Arabidopsis thaliana. Our work reveals that HEC function stabilizes cell fate in distinct zones of the shoot meristem thereby controlling the spatio-temporal dynamics of stem cell differentiation. Importantly, this activity is concomitant with the local modulation of cellular responses to cytokinin and auxin, two key phytohormones regulating cell behaviour. Mechanistically, we show that HEC factors transcriptionally control and physically interact with MONOPTEROS (MP), a key regulator of auxin signalling, and modulate the autocatalytic stabilization of auxin signalling output.</jats:p>},
  author       = {Gaillochet, Christophe and Stiehl, Thomas and Wenzl, Christian and Ripoll, Juan-José and Bailey-Steinitz, Lindsay J and Li, Lanxin and Pfeiffer, Anne and Miotk, Andrej and Hakenjos, Jana P and Forner, Joachim and Yanofsky, Martin F and Marciniak-Czochra, Anna and Lohmann, Jan U},
  issn         = {2050-084X},
  journal      = {eLife},
  publisher    = {eLife Sciences Publications},
  title        = {{Control of plant cell fate transitions by transcriptional and hormonal signals}},
  doi          = {10.7554/elife.30135},
  volume       = {6},
  year         = {2017},
}

