@article{12142, abstract = {Theory for liability-scale models of the underlying genetic basis of complex disease provides an important way to interpret, compare, and understand results generated from biological studies. In particular, through estimation of the liability-scale heritability (LSH), liability models facilitate an understanding and comparison of the relative importance of genetic and environmental risk factors that shape different clinically important disease outcomes. Increasingly, large-scale biobank studies that link genetic information to electronic health records, containing hundreds of disease diagnosis indicators that mostly occur infrequently within the sample, are becoming available. Here, we propose an extension of the existing liability-scale model theory suitable for estimating LSH in biobank studies of low-prevalence disease. In a simulation study, we find that our derived expression yields lower mean square error (MSE) and is less sensitive to prevalence misspecification as compared to previous transformations for diseases with =< 2% population prevalence and LSH of =< 0.45, especially if the biobank sample prevalence is less than that of the wider population. Applying our expression to 13 diagnostic outcomes of =< 3% prevalence in the UK Biobank study revealed important differences in LSH obtained from the different theoretical expressions that impact the conclusions made when comparing LSH across disease outcomes. This demonstrates the importance of careful consideration for estimation and prediction of low-prevalence disease outcomes and facilitates improved inference of the underlying genetic basis of =< 2% population prevalence diseases, especially where biobank sample ascertainment results in a healthier sample population.}, author = {Ojavee, Sven E. and Kutalik, Zoltan and Robinson, Matthew Richard}, issn = {0002-9297}, journal = {The American Journal of Human Genetics}, keywords = {Genetics (clinical), Genetics}, number = {11}, pages = {2009--2017}, publisher = {Elsevier}, title = {{Liability-scale heritability estimation for biobank studies of low-prevalence disease}}, doi = {10.1016/j.ajhg.2022.09.011}, volume = {109}, year = {2022}, } @article{12143, abstract = {MicroRNA (miRNA) and RNA interference (RNAi) pathways rely on small RNAs produced by Dicer endonucleases. Mammalian Dicer primarily supports the essential gene-regulating miRNA pathway, but how it is specifically adapted to miRNA biogenesis is unknown. We show that the adaptation entails a unique structural role of Dicer’s DExD/H helicase domain. Although mice tolerate loss of its putative ATPase function, the complete absence of the domain is lethal because it assures high-fidelity miRNA biogenesis. Structures of murine Dicer⋅miRNA precursor complexes revealed that the DExD/H domain has a helicase-unrelated structural function. It locks Dicer in a closed state, which facilitates miRNA precursor selection. Transition to a cleavage-competent open state is stimulated by Dicer-binding protein TARBP2. Absence of the DExD/H domain or its mutations unlocks the closed state, reduces substrate selectivity, and activates RNAi. Thus, the DExD/H domain structurally contributes to mammalian miRNA biogenesis and underlies mechanistical partitioning of miRNA and RNAi pathways.}, author = {Zapletal, David and Taborska, Eliska and Pasulka, Josef and Malik, Radek and Kubicek, Karel and Zanova, Martina and Much, Christian and Sebesta, Marek and Buccheri, Valeria and Horvat, Filip and Jenickova, Irena and Prochazkova, Michaela and Prochazka, Jan and Pinkas, Matyas and Novacek, Jiri and Joseph, Diego F. and Sedlacek, Radislav and Bernecky, Carrie A and O’Carroll, Dónal and Stefl, Richard and Svoboda, Petr}, issn = {1097-2765}, journal = {Molecular Cell}, keywords = {Cell Biology, Molecular Biology}, number = {21}, pages = {4064--4079.e13}, publisher = {Elsevier}, title = {{Structural and functional basis of mammalian microRNA biogenesis by Dicer}}, doi = {10.1016/j.molcel.2022.10.010}, volume = {82}, year = {2022}, } @article{12144, abstract = {The phytohormone auxin is the major coordinative signal in plant development1, mediating transcriptional reprogramming by a well-established canonical signalling pathway. TRANSPORT INHIBITOR RESPONSE 1 (TIR1)/AUXIN-SIGNALING F-BOX (AFB) auxin receptors are F-box subunits of ubiquitin ligase complexes. In response to auxin, they associate with Aux/IAA transcriptional repressors and target them for degradation via ubiquitination2,3. Here we identify adenylate cyclase (AC) activity as an additional function of TIR1/AFB receptors across land plants. Auxin, together with Aux/IAAs, stimulates cAMP production. Three separate mutations in the AC motif of the TIR1 C-terminal region, all of which abolish the AC activity, each render TIR1 ineffective in mediating gravitropism and sustained auxin-induced root growth inhibition, and also affect auxin-induced transcriptional regulation. These results highlight the importance of TIR1/AFB AC activity in canonical auxin signalling. They also identify a unique phytohormone receptor cassette combining F-box and AC motifs, and the role of cAMP as a second messenger in plants.}, author = {Qi, Linlin and Kwiatkowski, Mateusz and Chen, Huihuang and Hörmayer, Lukas and Sinclair, Scott A and Zou, Minxia and del Genio, Charo I. and Kubeš, Martin F. and Napier, Richard and Jaworski, Krzysztof and Friml, Jiří}, issn = {1476-4687}, journal = {Nature}, number = {7934}, pages = {133--138}, publisher = {Springer Nature}, title = {{Adenylate cyclase activity of TIR1/AFB auxin receptors in plants}}, doi = {10.1038/s41586-022-05369-7}, volume = {611}, year = {2022}, } @article{12145, abstract = {In the class of strictly convex smooth boundaries each of which has no strip around its boundary foliated by invariant curves, we prove that the Taylor coefficients of the “normalized” Mather’s β-function are invariant under C∞-conjugacies. In contrast, we prove that any two elliptic billiard maps are C0-conjugate near their respective boundaries, and C∞-conjugate, near the boundary and away from a line passing through the center of the underlying ellipse. We also prove that, if the billiard maps corresponding to two ellipses are topologically conjugate, then the two ellipses are similar.}, author = {Koudjinan, Edmond and Kaloshin, Vadim}, issn = {1468-4845}, journal = {Regular and Chaotic Dynamics}, keywords = {Mechanical Engineering, Applied Mathematics, Mathematical Physics, Modeling and Simulation, Statistical and Nonlinear Physics, Mathematics (miscellaneous)}, number = {6}, pages = {525--537}, publisher = {Springer Nature}, title = {{On some invariants of Birkhoff billiards under conjugacy}}, doi = {10.1134/S1560354722050021}, volume = {27}, year = {2022}, } @article{12146, abstract = {In this paper, we explore the stability and dynamical relevance of a wide variety of steady, time-periodic, quasiperiodic, and chaotic flows arising between orthogonally stretching parallel plates. We first explore the stability of all the steady flow solution families formerly identified by Ayats et al. [“Flows between orthogonally stretching parallel plates,” Phys. Fluids 33, 024103 (2021)], concluding that only the one that originates from the Stokesian approximation is actually stable. When both plates are shrinking at identical or nearly the same deceleration rates, this Stokesian flow exhibits a Hopf bifurcation that leads to stable time-periodic regimes. The resulting time-periodic orbits or flows are tracked for different Reynolds numbers and stretching rates while monitoring their Floquet exponents to identify secondary instabilities. It is found that these time-periodic flows also exhibit Neimark–Sacker bifurcations, generating stable quasiperiodic flows (tori) that may sometimes give rise to chaotic dynamics through a Ruelle–Takens–Newhouse scenario. However, chaotic dynamics is unusually observed, as the quasiperiodic flows generally become phase-locked through a resonance mechanism before a strange attractor may arise, thus restoring the time-periodicity of the flow. In this work, we have identified and tracked four different resonance regions, also known as Arnold tongues or horns. In particular, the 1 : 4 strong resonance region is explored in great detail, where the identified scenarios are in very good agreement with normal form theory. }, author = {Wang, B. and Ayats López, Roger and Meseguer, A. and Marques, F.}, issn = {1089-7666}, journal = {Physics of Fluids}, keywords = {Condensed Matter Physics, Fluid Flow and Transfer Processes, Mechanics of Materials, Computational Mechanics, Mechanical Engineering}, number = {11}, publisher = {AIP Publishing}, title = {{Phase-locking flows between orthogonally stretching parallel plates}}, doi = {10.1063/5.0124152}, volume = {34}, year = {2022}, } @article{12147, abstract = {Continuous-time neural networks are a class of machine learning systems that can tackle representation learning on spatiotemporal decision-making tasks. These models are typically represented by continuous differential equations. However, their expressive power when they are deployed on computers is bottlenecked by numerical differential equation solvers. This limitation has notably slowed down the scaling and understanding of numerous natural physical phenomena such as the dynamics of nervous systems. Ideally, we would circumvent this bottleneck by solving the given dynamical system in closed form. This is known to be intractable in general. Here, we show that it is possible to closely approximate the interaction between neurons and synapses—the building blocks of natural and artificial neural networks—constructed by liquid time-constant networks efficiently in closed form. To this end, we compute a tightly bounded approximation of the solution of an integral appearing in liquid time-constant dynamics that has had no known closed-form solution so far. This closed-form solution impacts the design of continuous-time and continuous-depth neural models. For instance, since time appears explicitly in closed form, the formulation relaxes the need for complex numerical solvers. Consequently, we obtain models that are between one and five orders of magnitude faster in training and inference compared with differential equation-based counterparts. More importantly, in contrast to ordinary differential equation-based continuous networks, closed-form networks can scale remarkably well compared with other deep learning instances. Lastly, as these models are derived from liquid networks, they show good performance in time-series modelling compared with advanced recurrent neural network models.}, author = {Hasani, Ramin and Lechner, Mathias and Amini, Alexander and Liebenwein, Lucas and Ray, Aaron and Tschaikowski, Max and Teschl, Gerald and Rus, Daniela}, issn = {2522-5839}, journal = {Nature Machine Intelligence}, keywords = {Artificial Intelligence, Computer Networks and Communications, Computer Vision and Pattern Recognition, Human-Computer Interaction, Software}, number = {11}, pages = {992--1003}, publisher = {Springer Nature}, title = {{Closed-form continuous-time neural networks}}, doi = {10.1038/s42256-022-00556-7}, volume = {4}, year = {2022}, } @article{12148, abstract = {We prove a general local law for Wigner matrices that optimally handles observables of arbitrary rank and thus unifies the well-known averaged and isotropic local laws. As an application, we prove a central limit theorem in quantum unique ergodicity (QUE): that is, we show that the quadratic forms of a general deterministic matrix A on the bulk eigenvectors of a Wigner matrix have approximately Gaussian fluctuation. For the bulk spectrum, we thus generalise our previous result [17] as valid for test matrices A of large rank as well as the result of Benigni and Lopatto [7] as valid for specific small-rank observables.}, author = {Cipolloni, Giorgio and Erdös, László and Schröder, Dominik J}, issn = {2050-5094}, journal = {Forum of Mathematics, Sigma}, keywords = {Computational Mathematics, Discrete Mathematics and Combinatorics, Geometry and Topology, Mathematical Physics, Statistics and Probability, Algebra and Number Theory, Theoretical Computer Science, Analysis}, publisher = {Cambridge University Press}, title = {{Rank-uniform local law for Wigner matrices}}, doi = {10.1017/fms.2022.86}, volume = {10}, year = {2022}, } @article{12278, abstract = {Mercury telluride (HgTe) thin films with a critical thickness of 6.5 nm are predicted to possess a gapless Dirac-like band structure. We report a comprehensive study on gated and optically doped samples by magnetooptical spectroscopy in the THz range. The quasi-classical analysis of the cyclotron resonance allowed the mapping of the band dispersion of Dirac charge carriers in a broad range of electron and hole doping. A smooth transition through the charge neutrality point between Dirac holes and electrons was observed. An additional peak coming from a second type of holes with an almost density-independent mass of around 0.04m0 was detected in the hole-doping range and attributed to an asymmetric spin splitting of the Dirac cone. Spectroscopic evidence for disorder-induced band energy fluctuations could not be detected in present cyclotron resonance experiments.}, author = {Shuvaev, Alexey and Dziom, Uladzislau and Gospodarič, Jan and Novik, Elena G. and Dobretsova, Alena A. and Mikhailov, Nikolay N. and Kvon, Ze Don and Pimenov, Andrei}, issn = {2079-4991}, journal = {Nanomaterials}, keywords = {General Materials Science, General Chemical Engineering}, number = {14}, publisher = {MDPI}, title = {{Band structure near the Dirac Point in HgTe quantum wells with critical thickness}}, doi = {10.3390/nano12142492}, volume = {12}, year = {2022}, } @article{12155, abstract = {The growing demand of thermal management in various fields such as miniaturized 5G chips has motivated researchers to develop new and high-performance solid-state refrigeration technologies, typically including multicaloric and thermoelectric (TE) cooling. Among them, TE cooling has attracted huge attention owing to its advantages of rapid response, large cooling temperature difference, high stability, and tunable device size. Bi2Te3-based alloys have long been the only commercialized TE cooling materials, while novel systems SnSe and Mg3(Bi,Sb)2 have recently been discovered as potential candidates. However, challenges and problems still require to be summarized and further resolved for realizing better cooling performance. In this review, we systematically investigate TE cooling from its internal mechanism, crucial parameters, to device design and applications. Furthermore, we summarize the current optimization strategies for existing TE cooling materials, and finally provide some personal prospects especially the material-planification concept on future research on establishing better TE cooling.}, author = {Qin, Yongxin and Qin, Bingchao and Wang, Dongyang and Chang, Cheng and Zhao, Li-Dong}, issn = {1754-5706}, journal = {Energy & Environmental Science}, keywords = {Pollution, Nuclear Energy and Engineering, Renewable Energy, Sustainability and the Environment, Environmental Chemistry}, number = {11}, pages = {4527--4541}, publisher = {Royal Society of Chemistry}, title = {{Solid-state cooling: Thermoelectrics}}, doi = {10.1039/d2ee02408j}, volume = {15}, year = {2022}, } @article{12151, abstract = {The k-sample G(k,W) from a graphon W:[0,1]2→[0,1] is the random graph on {1,…,k}, where we sample x1,…,xk∈[0,1] uniformly at random and make each pair {i,j}⊆{1,…,k} an edge with probability W(xi,xj), with all these choices being mutually independent. Let the random variable Xk(W) be the number of edges in G(k,W). Vera T. Sós asked in 2012 whether two graphons U, W are necessarily weakly isomorphic if the random variables Xk(U) and Xk(W) have the same distribution for every integer k≥2. This question when one of the graphons W is a constant function was answered positively by Endre Csóka and independently by Jacob Fox, Tomasz Łuczak and Vera T. Sós. Here we investigate the question when W is a 2-step graphon and prove that the answer is positive for a 3-dimensional family of such graphons. We also present some related results.}, author = {Cooley, Oliver and Kang, M. and Pikhurko, O.}, issn = {1588-2632}, journal = {Acta Mathematica Hungarica}, keywords = {graphon, k-sample, graphon forcing, graph container}, pages = {1--26}, publisher = {Springer Nature}, title = {{On a question of Vera T. Sós about size forcing of graphons}}, doi = {10.1007/s10474-022-01265-8}, volume = {168}, year = {2022}, } @article{11737, abstract = {Spin-orbit coupling in thin HgTe quantum wells results in a relativistic-like electron band structure, making it a versatile solid state platform to observe and control nontrivial electrodynamic phenomena. Here we report an observation of universal terahertz (THz) transparency determined by fine-structure constant α≈1/137 in 6.5-nm-thick HgTe layer, close to the critical thickness separating phases with topologically different electronic band structure. Using THz spectroscopy in a magnetic field we obtain direct evidence of asymmetric spin splitting of the Dirac cone. This particle-hole asymmetry facilitates optical control of edge spin currents in the quantum wells.}, author = {Dziom, Uladzislau and Shuvaev, A. and Gospodarič, J. and Novik, E. G. and Dobretsova, A. A. and Mikhailov, N. N. and Kvon, Z. D. and Alpichshev, Zhanybek and Pimenov, A.}, issn = {2469-9969}, journal = {Physical Review B}, number = {4}, publisher = {American Physical Society}, title = {{Universal transparency and asymmetric spin splitting near the Dirac point in HgTe quantum wells}}, doi = {10.1103/PhysRevB.106.045302}, volume = {106}, year = {2022}, } @article{12186, abstract = {Activation of cell-surface and intracellular receptor-mediated immunity results in rapid transcriptional reprogramming that underpins disease resistance. However, the mechanisms by which co-activation of both immune systems lead to transcriptional changes are not clear. Here, we combine RNA-seq and ATAC-seq to define changes in gene expression and chromatin accessibility. Activation of cell-surface or intracellular receptor-mediated immunity, or both, increases chromatin accessibility at induced defence genes. Analysis of ATAC-seq and RNA-seq data combined with publicly available information on transcription factor DNA-binding motifs enabled comparison of individual gene regulatory networks activated by cell-surface or intracellular receptor-mediated immunity, or by both. These results and analyses reveal overlapping and conserved transcriptional regulatory mechanisms between the two immune systems.}, author = {Ding, Pingtao and Sakai, Toshiyuki and Krishna Shrestha, Ram and Manosalva Perez, Nicolas and Guo, Wenbin and Ngou, Bruno Pok Man and He, Shengbo and Liu, Chang and Feng, Xiaoqi and Zhang, Runxuan and Vandepoele, Klaas and MacLean, Dan and Jones, Jonathan D G}, issn = {0022-0957}, journal = {Journal of Experimental Botany}, keywords = {Plant Science, Physiology}, number = {22}, pages = {7927--7941}, publisher = {Oxford University Press}, title = {{Chromatin accessibility landscapes activated by cell-surface and intracellular immune receptors}}, doi = {10.1093/jxb/erab373}, volume = {72}, year = {2021}, } @article{12187, abstract = {Genomes of germ cells present an existential vulnerability to organisms because germ cell mutations will propagate to future generations. Transposable elements are one source of such mutations. In the small flowering plant Arabidopsis, Long et al. found that genome methylation in the male germline is directed by small interfering RNAs (siRNAs) imperfectly transcribed from transposons (see the Perspective by Mosher). These germline siRNAs silence germline transposons and establish inherited methylation patterns in sperm, thus maintaining the integrity of the plant genome across generations.}, author = {Long, Jincheng and Walker, James and She, Wenjing and Aldridge, Billy and Gao, Hongbo and Deans, Samuel and Vickers, Martin and Feng, Xiaoqi}, issn = {0036-8075}, journal = {Science}, keywords = {Multidisciplinary}, number = {6550}, publisher = {American Association for the Advancement of Science (AAAS)}, title = {{Nurse cell--derived small RNAs define paternal epigenetic inheritance in Arabidopsis}}, doi = {10.1126/science.abh0556}, volume = {373}, year = {2021}, } @article{12308, abstract = {Let P and Q be two points on an elliptic curve defined over a number field K. For α∈End(E), define Bα to be the OK-integral ideal generated by the denominator of x(α(P)+Q). Let O be a subring of End(E), that is a Dedekind domain. We will study the sequence {Bα}α∈O. We will show that, for all but finitely many α∈O, the ideal Bα has a primitive divisor when P is a non-torsion point and there exist two endomorphisms g≠0 and f so that f(P)=g(Q). This is a generalization of previous results on elliptic divisibility sequences.}, author = {Verzobio, Matteo}, issn = {2522-0160}, journal = {Research in Number Theory}, keywords = {Algebra and Number Theory}, number = {2}, publisher = {Springer Nature}, title = {{Primitive divisors of sequences associated to elliptic curves with complex multiplication}}, doi = {10.1007/s40993-021-00267-9}, volume = {7}, year = {2021}, } @article{12309, abstract = {Take a rational elliptic curve defined by the equation y2=x3+ax in minimal form and consider the sequence Bn of the denominators of the abscissas of the iterate of a non-torsion point. We show that B5m has a primitive divisor for every m. Then, we show how to generalize this method to the terms of the form Bmp with p a prime congruent to 1 modulo 4.}, author = {Verzobio, Matteo}, issn = {0065-1036}, journal = {Acta Arithmetica}, keywords = {Algebra and Number Theory}, number = {2}, pages = {129--168}, publisher = {Institute of Mathematics, Polish Academy of Sciences}, title = {{Primitive divisors of elliptic divisibility sequences for elliptic curves with j=1728}}, doi = {10.4064/aa191016-30-7}, volume = {198}, year = {2021}, } @unpublished{12314, abstract = {In literature, there are two different definitions of elliptic divisibility sequences. The first one says that a sequence of integers $\{h_n\}_{n\geq 0}$ is an elliptic divisibility sequence if it verifies the recurrence relation $h_{m+n}h_{m-n}h_{r}^2=h_{m+r}h_{m-r}h_{n}^2-h_{n+r}h_{n-r}h_{m}^2$ for every natural number $m\geq n\geq r$. The second definition says that a sequence of integers $\{\beta_n\}_{n\geq 0}$ is an elliptic divisibility sequence if it is the sequence of the square roots (chosen with an appropriate sign) of the denominators of the abscissas of the iterates of a point on a rational elliptic curve. It is well-known that the two sequences are not equivalent. Hence, given a sequence of the denominators $\{\beta_n\}_{n\geq 0}$, in general does not hold $\beta_{m+n}\beta_{m-n}\beta_{r}^2=\beta_{m+r}\beta_{m-r}\beta_{n}^2-\beta_{n+r}\beta_{n-r}\beta_{m}^2$ for $m\geq n\geq r$. We will prove that the recurrence relation above holds for $\{\beta_n\}_{n\geq 0}$ under some conditions on the indexes $m$, $n$, and $r$.}, author = {Verzobio, Matteo}, booktitle = {arXiv}, title = {{A recurrence relation for elliptic divisibility sequences}}, doi = {10.48550/arXiv.2102.07573}, year = {2021}, } @article{12583, abstract = {Peruvian glaciers are important contributors to dry season runoff for agriculture and hydropower, but they are at risk of disappearing due to climate change. We applied a physically based, energy balance melt model at five on-glacier sites within the Peruvian Cordilleras Blanca and Vilcanota. Net shortwave radiation dominates the energy balance, and despite this flux being higher in the dry season, melt rates are lower due to losses from net longwave radiation and the latent heat flux. The sensible heat flux is a relatively small contributor to melt energy. At three of the sites the wet season snowpack was discontinuous, forming and melting within a daily to weekly timescale, and resulting in highly variable melt rates closely related to precipitation dynamics. Cold air temperatures due to a strong La Niña year at Shallap Glacier (Cordillera Blanca) resulted in a continuous wet season snowpack, significantly reducing wet season ablation. Sublimation was most important at the highest site in the accumulation zone of the Quelccaya Ice Cap (Cordillera Vilcanota), accounting for 81% of ablation, compared to 2%–4% for the other sites. Air temperature and precipitation inputs were perturbed to investigate the climate sensitivity of the five glaciers. At the lower sites warmer air temperatures resulted in a switch from snowfall to rain, so that ablation was increased via the decrease in albedo and increase in net shortwave radiation. At the top of Quelccaya Ice Cap warming caused melting to replace sublimation so that ablation increased nonlinearly with air temperature.}, author = {Fyffe, Catriona L. and Potter, Emily and Fugger, Stefan and Orr, Andrew and Fatichi, Simone and Loarte, Edwin and Medina, Katy and Hellström, Robert Å. and Bernat, Maud and Aubry‐Wake, Caroline and Gurgiser, Wolfgang and Perry, L. Baker and Suarez, Wilson and Quincey, Duncan J. and Pellicciotti, Francesca}, issn = {2169-8996}, journal = {Journal of Geophysical Research: Atmospheres}, keywords = {Space and Planetary Science, Earth and Planetary Sciences (miscellaneous), Atmospheric Science, Geophysics}, number = {23}, publisher = {American Geophysical Union}, title = {{The energy and mass balance of Peruvian Glaciers}}, doi = {10.1029/2021jd034911}, volume = {126}, year = {2021}, } @article{12584, abstract = {This project explored the integrated use of satellite, ground observations and hydrological distributed models to support water resources assessment and monitoring in High Mountain Asia (HMA). Hydrological data products were generated taking advantage of the synergies of European and Chinese data assets and space-borne observation systems. Energy-budget-based glacier mass balance and hydrological models driven by satellite observations were developed. These models can be applied to describe glacier-melt contribution to river flow. Satellite hydrological data products were used for forcing, calibration, validation and data assimilation in distributed river basin models. A pilot study was carried out on the Red River basin. Multiple hydrological data products were generated using the data collected by Chinese satellites. A new Evapo-Transpiration (ET) dataset from 2000 to 2018 was generated, including plant transpiration, soil evaporation, rainfall interception loss, snow/ice sublimation and open water evaporation. Higher resolution data were used to characterize glaciers and their response to environmental forcing. These studies focused on the Parlung Zangbo Basin, where glacier facies were mapped with GaoFeng (GF), Sentinal-2/Multi-Spectral Imager (S2/MSI) and Landsat8/Operational Land Imager (L8/OLI) data. The geodetic mass balance was estimated between 2000 and 2017 with Zi-Yuan (ZY)-3 Stereo Images and the SRTM DEM. Surface velocity was studied with Landsat5/Thematic Mapper (L5/TM), L8/OLI and S2/MSI data over the period 2013–2019. An updated method was developed to improve the retrieval of glacier albedo by correcting glacier reflectance for anisotropy, and a new dataset on glacier albedo was generated for the period 2001–2020. A detailed glacier energy and mass balance model was developed with the support of field experiments at the Parlung No. 4 Glacier and the 24 K Glacier, both in the Tibetan Plateau. Besides meteorological measurements, the field experiments included glaciological and hydrological measurements. The energy balance model was formulated in terms of enthalpy for easier treatment of water phase transitions. The model was applied to assess the spatial variability in glacier melt. In the Parlung No. 4 Glacier, the accumulated glacier melt was between 1.5 and 2.5 m w.e. in the accumulation zone and between 4.5 and 6.0 m w.e. in the ablation zone, reaching 6.5 m w.e. at the terminus. The seasonality in the glacier mass balance was observed by combining intensive field campaigns with continuous automatic observations. The linkage of the glacier and snowpack mass balance with water resources in a river basin was analyzed in the Chiese (Italy) and Heihe (China) basins by developing and applying integrated hydrological models using satellite retrievals in multiple ways. The model FEST-WEB was calibrated using retrievals of Land Surface Temperature (LST) to map soil hydrological properties. A watershed model was developed by coupling ecohydrological and socioeconomic systems. Integrated modeling is supported by an updated and parallelized data assimilation system. The latter exploits retrievals of brightness temperature (Advanced Microwave Scanning Radiometer, AMSR), LST (Moderate Resolution Imaging Spectroradiometer, MODIS), precipitation (Tropical Rainfall Measuring Mission (TRMM) and FengYun (FY)-2D) and in-situ measurements. In the case study on the Red River Basin, a new algorithm has been applied to disaggregate the SMOS (Soil Moisture and Ocean Salinity) soil moisture retrievals by making use of the correlation between evaporative fraction and soil moisture.}, author = {Menenti, Massimo and Li, Xin and Jia, Li and Yang, Kun and Pellicciotti, Francesca and Mancini, Marco and Shi, Jiancheng and Escorihuela, Maria José and Zheng, Chaolei and Chen, Qiting and Lu, Jing and Zhou, Jie and Hu, Guangcheng and Ren, Shaoting and Zhang, Jing and Liu, Qinhuo and Qiu, Yubao and Huang, Chunlin and Zhou, Ji and Han, Xujun and Pan, Xiaoduo and Li, Hongyi and Wu, Yerong and Ding, Baohong and Yang, Wei and Buri, Pascal and McCarthy, Michael J. and Miles, Evan S. and Shaw, Thomas E. and Ma, Chunfeng and Zhou, Yanzhao and Corbari, Chiara and Li, Rui and Zhao, Tianjie and Stefan, Vivien and Gao, Qi and Zhang, Jingxiao and Xie, Qiuxia and Wang, Ning and Sun, Yibo and Mo, Xinyu and Jia, Junru and Jouberton, Achille Pierre and Kneib, Marin and Fugger, Stefan and Paciolla, Nicola and Paolini, Giovanni}, issn = {2072-4292}, journal = {Remote Sensing}, keywords = {General Earth and Planetary Sciences}, number = {24}, publisher = {MDPI}, title = {{Multi-source hydrological data products to monitor High Asian river basins and regional water security}}, doi = {10.3390/rs13245122}, volume = {13}, year = {2021}, } @article{12585, abstract = {Glaciers in High Mountain Asia generate meltwater that supports the water needs of 250 million people, but current knowledge of annual accumulation and ablation is limited to sparse field measurements biased in location and glacier size. Here, we present altitudinally-resolved specific mass balances (surface, internal, and basal combined) for 5527 glaciers in High Mountain Asia for 2000–2016, derived by correcting observed glacier thinning patterns for mass redistribution due to ice flow. We find that 41% of glaciers accumulated mass over less than 20% of their area, and only 60% ± 10% of regional annual ablation was compensated by accumulation. Even without 21st century warming, 21% ± 1% of ice volume will be lost by 2100 due to current climatic-geometric imbalance, representing a reduction in glacier ablation into rivers of 28% ± 1%. The ablation of glaciers in the Himalayas and Tien Shan was mostly unsustainable and ice volume in these regions will reduce by at least 30% by 2100. The most important and vulnerable glacier-fed river basins (Amu Darya, Indus, Syr Darya, Tarim Interior) were supplied with >50% sustainable glacier ablation but will see long-term reductions in ice mass and glacier meltwater supply regardless of the Karakoram Anomaly.}, author = {Miles, Evan and McCarthy, Michael and Dehecq, Amaury and Kneib, Marin and Fugger, Stefan and Pellicciotti, Francesca}, issn = {2041-1723}, journal = {Nature Communications}, keywords = {General Physics and Astronomy, General Biochemistry, Genetics and Molecular Biology, General Chemistry, Multidisciplinary}, publisher = {Springer Nature}, title = {{Health and sustainability of glaciers in High Mountain Asia}}, doi = {10.1038/s41467-021-23073-4}, volume = {12}, year = {2021}, } @article{12586, abstract = {Ice cliffs are common on debris-covered glaciers and have relatively high melt rates due to their direct exposure to incoming radiation. Previous studies have shown that their number and relative area can change considerably from year to year, but this variability has not been explored, in part because available cliff observations are irregular. Here, we systematically mapped and tracked ice cliffs across four debris-covered glaciers in High Mountain Asia for every late ablation season from 2009 to 2019 using high-resolution multi-spectral satellite imagery. We then quantified the processes occurring at the feature scale to train a stochastic birth-death model to represent the cliff population dynamics. Our results show that while the cliff relative area can change by up to 20% from year to year, the natural long-term variability is constrained, thus defining a glacier-specific cliff carrying capacity. In a subsequent step, the inclusion of external drivers related to climate, glacier dynamics, and hydrology highlights the influence of these variables on the cliff population dynamics, which is usually not a direct one due to the complexity and interdependence of the processes taking place at the glacier surface. In some extreme cases (here, a glacier surge), these external drivers may lead to a reorganization of the cliffs at the glacier surface and a change in the natural variability. These results have implications for the melt of debris-covered glaciers, in addition to showing the high rate of changes at their surface and highlighting some of the links between cliff population and glacier state.}, author = {Kneib, M. and Miles, E. S. and Buri, P. and Molnar, P. and McCarthy, M. and Fugger, S. and Pellicciotti, Francesca}, issn = {2169-9003}, journal = {Journal of Geophysical Research: Earth Surface}, keywords = {Earth-Surface Processes, Geophysics}, number = {10}, publisher = {American Geophysical Union}, title = {{Interannual dynamics of ice cliff populations on debris‐covered glaciers from remote sensing observations and stochastic modeling}}, doi = {10.1029/2021jf006179}, volume = {126}, year = {2021}, }