[{"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","date_updated":"2023-09-07T12:56:42Z","acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"},{"_id":"EM-Fac"},{"_id":"SSU"}],"publication_identifier":{"issn":["2663-337X"]},"has_accepted_license":"1","year":"2019","oa_version":"Published Version","publication_status":"published","oa":1,"file_date_updated":"2020-07-14T12:47:52Z","article_processing_charge":"No","file":[{"date_created":"2019-12-19T15:18:11Z","content_type":"application/zip","file_id":"7194","relation":"source_file","date_updated":"2020-07-14T12:47:52Z","access_level":"closed","checksum":"585583c1c875c5d9525703a539668a7c","file_name":"DocumentSourceFiles.zip","creator":"cschwayer","file_size":19431292},{"relation":"main_file","file_id":"7195","content_type":"application/pdf","date_created":"2019-12-19T15:19:21Z","file_size":19226428,"creator":"cschwayer","file_name":"Thesis_CS_final.pdf","checksum":"9b9b24351514948d27cec659e632e2cd","access_level":"open_access","date_updated":"2020-07-14T12:47:52Z"}],"_id":"7186","abstract":[{"lang":"eng","text":"Tissue morphogenesis in developmental or physiological processes is regulated by molecular\r\nand mechanical signals. While the molecular signaling cascades are increasingly well\r\ndescribed, the mechanical signals affecting tissue shape changes have only recently been\r\nstudied in greater detail. To gain more insight into the mechanochemical and biophysical\r\nbasis of an epithelial spreading process (epiboly) in early zebrafish development, we studied\r\ncell-cell junction formation and actomyosin network dynamics at the boundary between\r\nsurface layer epithelial cells (EVL) and the yolk syncytial layer (YSL). During zebrafish epiboly,\r\nthe cell mass sitting on top of the yolk cell spreads to engulf the yolk cell by the end of\r\ngastrulation. It has been previously shown that an actomyosin ring residing within the YSL\r\npulls on the EVL tissue through a cable-constriction and a flow-friction motor, thereby\r\ndragging the tissue vegetal wards. Pulling forces are likely transmitted from the YSL\r\nactomyosin ring to EVL cells; however, the nature and formation of the junctional structure\r\nmediating this process has not been well described so far. Therefore, our main aim was to\r\ndetermine the nature, dynamics and potential function of the EVL-YSL junction during this\r\nepithelial tissue spreading. Specifically, we show that the EVL-YSL junction is a\r\nmechanosensitive structure, predominantly made of tight junction (TJ) proteins. The process\r\nof TJ mechanosensation depends on the retrograde flow of non-junctional, phase-separated\r\nZonula Occludens-1 (ZO-1) protein clusters towards the EVL-YSL boundary. Interestingly, we\r\ncould demonstrate that ZO-1 is present in a non-junctional pool on the surface of the yolk\r\ncell, and ZO-1 undergoes a phase separation process that likely renders the protein\r\nresponsive to flows. These flows are directed towards the junction and mediate proper\r\ntension-dependent recruitment of ZO-1. Upon reaching the EVL-YSL junction ZO-1 gets\r\nincorporated into the junctional pool mediated through its direct actin-binding domain.\r\nWhen the non-junctional pool and/or ZO-1 direct actin binding is absent, TJs fail in their\r\nproper mechanosensitive responses resulting in slower tissue spreading. We could further\r\ndemonstrate that depletion of ZO proteins within the YSL results in diminished actomyosin\r\nring formation. This suggests that a mechanochemical feedback loop is at work during\r\nzebrafish epiboly: ZO proteins help in proper actomyosin ring formation and actomyosin\r\ncontractility and flows positively influence ZO-1 junctional recruitment. Finally, such a\r\nmesoscale polarization process mediated through the flow of phase-separated protein\r\nclusters might have implications for other processes such as immunological synapse\r\nformation, C. elegans zygote polarization and wound healing."}],"date_published":"2019-12-16T00:00:00Z","related_material":{"record":[{"status":"public","id":"1096","relation":"dissertation_contains"},{"status":"public","id":"7001","relation":"part_of_dissertation"}]},"language":[{"iso":"eng"}],"doi":"10.15479/AT:ISTA:7186","ddc":["570"],"citation":{"mla":"Schwayer, Cornelia. <i>Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow</i>. Institute of Science and Technology Austria, 2019, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:7186\">10.15479/AT:ISTA:7186</a>.","ista":"Schwayer C. 2019. Mechanosensation of tight junctions depends on ZO-1 phase separation and flow. Institute of Science and Technology Austria.","ieee":"C. Schwayer, “Mechanosensation of tight junctions depends on ZO-1 phase separation and flow,” Institute of Science and Technology Austria, 2019.","chicago":"Schwayer, Cornelia. “Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow.” Institute of Science and Technology Austria, 2019. <a href=\"https://doi.org/10.15479/AT:ISTA:7186\">https://doi.org/10.15479/AT:ISTA:7186</a>.","apa":"Schwayer, C. (2019). <i>Mechanosensation of tight junctions depends on ZO-1 phase separation and flow</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:7186\">https://doi.org/10.15479/AT:ISTA:7186</a>","ama":"Schwayer C. Mechanosensation of tight junctions depends on ZO-1 phase separation and flow. 2019. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:7186\">10.15479/AT:ISTA:7186</a>","short":"C. Schwayer, Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow, Institute of Science and Technology Austria, 2019."},"title":"Mechanosensation of tight junctions depends on ZO-1 phase separation and flow","day":"16","type":"dissertation","author":[{"last_name":"Schwayer","full_name":"Schwayer, Cornelia","first_name":"Cornelia","id":"3436488C-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5130-2226"}],"alternative_title":["ISTA Thesis"],"publisher":"Institute of Science and Technology Austria","degree_awarded":"PhD","department":[{"_id":"CaHe"}],"status":"public","page":"107","month":"12","supervisor":[{"last_name":"Heisenberg","full_name":"Heisenberg, Carl-Philipp J","first_name":"Carl-Philipp J","orcid":"0000-0002-0912-4566","id":"39427864-F248-11E8-B48F-1D18A9856A87"}],"date_created":"2019-12-16T14:26:14Z"},{"title":"In-medium bound states of two bosonic impurities in a one-dimensional Fermi gas","ec_funded":1,"citation":{"mla":"Huber, D., et al. “In-Medium Bound States of Two Bosonic Impurities in a One-Dimensional Fermi Gas.” <i>Physical Review Research</i>, vol. 1, no. 3, 033177, American Physical Society, 2019, doi:<a href=\"https://doi.org/10.1103/physrevresearch.1.033177\">10.1103/physrevresearch.1.033177</a>.","ieee":"D. Huber, H.-W. Hammer, and A. Volosniev, “In-medium bound states of two bosonic impurities in a one-dimensional Fermi gas,” <i>Physical Review Research</i>, vol. 1, no. 3. American Physical Society, 2019.","ista":"Huber D, Hammer H-W, Volosniev A. 2019. In-medium bound states of two bosonic impurities in a one-dimensional Fermi gas. Physical Review Research. 1(3), 033177.","chicago":"Huber, D., H.-W. Hammer, and Artem Volosniev. “In-Medium Bound States of Two Bosonic Impurities in a One-Dimensional Fermi Gas.” <i>Physical Review Research</i>. American Physical Society, 2019. <a href=\"https://doi.org/10.1103/physrevresearch.1.033177\">https://doi.org/10.1103/physrevresearch.1.033177</a>.","apa":"Huber, D., Hammer, H.-W., &#38; Volosniev, A. (2019). In-medium bound states of two bosonic impurities in a one-dimensional Fermi gas. <i>Physical Review Research</i>. American Physical Society. <a href=\"https://doi.org/10.1103/physrevresearch.1.033177\">https://doi.org/10.1103/physrevresearch.1.033177</a>","ama":"Huber D, Hammer H-W, Volosniev A. In-medium bound states of two bosonic impurities in a one-dimensional Fermi gas. <i>Physical Review Research</i>. 2019;1(3). doi:<a href=\"https://doi.org/10.1103/physrevresearch.1.033177\">10.1103/physrevresearch.1.033177</a>","short":"D. Huber, H.-W. Hammer, A. Volosniev, Physical Review Research 1 (2019)."},"type":"journal_article","author":[{"last_name":"Huber","full_name":"Huber, D.","first_name":"D."},{"first_name":"H.-W.","full_name":"Hammer, H.-W.","last_name":"Hammer"},{"orcid":"0000-0003-0393-5525","id":"37D278BC-F248-11E8-B48F-1D18A9856A87","last_name":"Volosniev","full_name":"Volosniev, Artem","first_name":"Artem"}],"day":"16","project":[{"grant_number":"754411","name":"ISTplus - Postdoctoral Fellowships","call_identifier":"H2020","_id":"260C2330-B435-11E9-9278-68D0E5697425"}],"ddc":["530"],"doi":"10.1103/physrevresearch.1.033177","language":[{"iso":"eng"}],"date_created":"2019-12-17T13:03:41Z","month":"12","publisher":"American Physical Society","intvolume":"         1","status":"public","department":[{"_id":"MiLe"}],"quality_controlled":"1","publication":"Physical Review Research","oa_version":"Published Version","year":"2019","has_accepted_license":"1","article_type":"original","publication_identifier":{"issn":["2643-1564"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2024-02-28T13:11:40Z","external_id":{"arxiv":["1908.02483"]},"issue":"3","article_processing_charge":"No","arxiv":1,"abstract":[{"lang":"eng","text":"We investigate the ground-state energy of a one-dimensional Fermi gas with two bosonic impurities. We consider spinless fermions with no fermion-fermion interactions. The fermion-impurity and impurity-impurity interactions are modeled with Dirac delta functions. First, we study the case where impurity and fermion have equal masses, and the impurity-impurity two-body interaction is identical to the fermion-impurity interaction, such that the system is solvable with the Bethe ansatz. For attractive interactions, we find that the energy of the impurity-impurity subsystem is below the energy of the bound state that exists without the Fermi gas. We interpret this as a manifestation of attractive boson-boson interactions induced by the fermionic medium, and refer to the impurity-impurity subsystem as an in-medium bound state. For repulsive interactions, we find no in-medium bound states. Second, we construct an effective model to describe these interactions, and compare its predictions to the exact solution. We use this effective model to study nonintegrable systems with unequal masses and/or potentials. We discuss parameter regimes for which impurity-impurity attraction induced by the Fermi gas can lead to the formation of in-medium bound states made of bosons that repel each other in the absence of the Fermi gas."}],"_id":"7190","date_published":"2019-12-16T00:00:00Z","file":[{"relation":"main_file","file_id":"7193","content_type":"application/pdf","date_created":"2019-12-18T07:13:14Z","file_size":1370022,"creator":"dernst","file_name":"2019_PhysRevResearch_Huber.pdf","checksum":"382eb67e62a77052a23887332d363f96","access_level":"open_access","date_updated":"2020-07-14T12:47:52Z"}],"article_number":"033177","oa":1,"publication_status":"published","volume":1,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"file_date_updated":"2020-07-14T12:47:52Z"},{"article_processing_charge":"No","_id":"7197","abstract":[{"lang":"eng","text":"During bacterial cell division, the tubulin-homolog FtsZ forms a ring-like structure at the center of the cell. This Z-ring not only organizes the division machinery, but treadmilling of FtsZ filaments was also found to play a key role in distributing proteins at the division site. What regulates the architecture, dynamics and stability of the Z-ring is currently unknown, but FtsZ-associated proteins are known to play an important role. Here, using an in vitro reconstitution approach, we studied how the well-conserved protein ZapA affects FtsZ treadmilling and filament organization into large-scale patterns. Using high-resolution fluorescence microscopy and quantitative image analysis, we found that ZapA cooperatively increases the spatial order of the filament network, but binds only transiently to FtsZ filaments and has no effect on filament length and treadmilling velocity. Together, our data provides a model for how FtsZ-associated proteins can increase the precision and stability of the bacterial cell division machinery in a switch-like manner."}],"date_published":"2019-12-17T00:00:00Z","article_number":"5744","file":[{"checksum":"a1b44b427ba341383197790d0e8789fa","access_level":"open_access","date_updated":"2020-07-14T12:47:53Z","file_size":8488733,"creator":"dernst","file_name":"2019_NatureComm_Caldas.pdf","date_created":"2019-12-23T07:34:56Z","file_id":"7208","relation":"main_file","content_type":"application/pdf"}],"oa":1,"publication_status":"published","volume":10,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"file_date_updated":"2020-07-14T12:47:53Z","has_accepted_license":"1","year":"2019","oa_version":"Published Version","article_type":"original","acknowledged_ssus":[{"_id":"LifeSc"},{"_id":"Bio"}],"publication_identifier":{"issn":["2041-1723"]},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","date_updated":"2023-09-07T13:18:51Z","scopus_import":"1","external_id":{"isi":["000503009300001"]},"date_created":"2019-12-20T12:22:57Z","month":"12","isi":1,"publisher":"Springer Nature","intvolume":"        10","status":"public","quality_controlled":"1","department":[{"_id":"MaLo"},{"_id":"BjHo"}],"publication":"Nature Communications","title":"Cooperative ordering of treadmilling filaments in cytoskeletal networks of FtsZ and its crosslinker ZapA","ec_funded":1,"citation":{"mla":"Dos Santos Caldas, Paulo R., et al. “Cooperative Ordering of Treadmilling Filaments in Cytoskeletal Networks of FtsZ and Its Crosslinker ZapA.” <i>Nature Communications</i>, vol. 10, 5744, Springer Nature, 2019, doi:<a href=\"https://doi.org/10.1038/s41467-019-13702-4\">10.1038/s41467-019-13702-4</a>.","chicago":"Dos Santos Caldas, Paulo R, Maria D Lopez Pelegrin, Daniel J. G. Pearce, Nazmi B Budanur, Jan Brugués, and Martin Loose. “Cooperative Ordering of Treadmilling Filaments in Cytoskeletal Networks of FtsZ and Its Crosslinker ZapA.” <i>Nature Communications</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s41467-019-13702-4\">https://doi.org/10.1038/s41467-019-13702-4</a>.","ieee":"P. R. Dos Santos Caldas, M. D. Lopez Pelegrin, D. J. G. Pearce, N. B. Budanur, J. Brugués, and M. Loose, “Cooperative ordering of treadmilling filaments in cytoskeletal networks of FtsZ and its crosslinker ZapA,” <i>Nature Communications</i>, vol. 10. Springer Nature, 2019.","ista":"Dos Santos Caldas PR, Lopez Pelegrin MD, Pearce DJG, Budanur NB, Brugués J, Loose M. 2019. Cooperative ordering of treadmilling filaments in cytoskeletal networks of FtsZ and its crosslinker ZapA. Nature Communications. 10, 5744.","ama":"Dos Santos Caldas PR, Lopez Pelegrin MD, Pearce DJG, Budanur NB, Brugués J, Loose M. Cooperative ordering of treadmilling filaments in cytoskeletal networks of FtsZ and its crosslinker ZapA. <i>Nature Communications</i>. 2019;10. doi:<a href=\"https://doi.org/10.1038/s41467-019-13702-4\">10.1038/s41467-019-13702-4</a>","apa":"Dos Santos Caldas, P. R., Lopez Pelegrin, M. D., Pearce, D. J. G., Budanur, N. B., Brugués, J., &#38; Loose, M. (2019). Cooperative ordering of treadmilling filaments in cytoskeletal networks of FtsZ and its crosslinker ZapA. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-019-13702-4\">https://doi.org/10.1038/s41467-019-13702-4</a>","short":"P.R. Dos Santos Caldas, M.D. Lopez Pelegrin, D.J.G. Pearce, N.B. Budanur, J. Brugués, M. Loose, Nature Communications 10 (2019)."},"author":[{"orcid":"0000-0001-6730-4461","id":"38FCDB4C-F248-11E8-B48F-1D18A9856A87","last_name":"Dos Santos Caldas","full_name":"Dos Santos Caldas, Paulo R","first_name":"Paulo R"},{"first_name":"Maria D","full_name":"Lopez Pelegrin, Maria D","last_name":"Lopez Pelegrin","id":"319AA9CE-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Pearce","first_name":"Daniel J. G.","full_name":"Pearce, Daniel J. G."},{"full_name":"Budanur, Nazmi B","first_name":"Nazmi B","last_name":"Budanur","id":"3EA1010E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-0423-5010"},{"last_name":"Brugués","full_name":"Brugués, Jan","first_name":"Jan"},{"last_name":"Loose","full_name":"Loose, Martin","first_name":"Martin","orcid":"0000-0001-7309-9724","id":"462D4284-F248-11E8-B48F-1D18A9856A87"}],"type":"journal_article","day":"17","project":[{"name":"Self-Organization of the Bacterial Cell","grant_number":"679239","_id":"2595697A-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"},{"_id":"260D98C8-B435-11E9-9278-68D0E5697425","name":"Reconstitution of Bacterial Cell Division Using Purified Components"}],"related_material":{"record":[{"status":"public","relation":"dissertation_contains","id":"8358"}]},"doi":"10.1038/s41467-019-13702-4","ddc":["570"],"language":[{"iso":"eng"}]},{"publication_status":"published","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1710.02323"}],"oa":1,"volume":55,"arxiv":1,"article_processing_charge":"No","issue":"3","date_published":"2019-09-25T00:00:00Z","_id":"72","abstract":[{"text":"We consider the totally asymmetric simple exclusion process (TASEP) with non-random initial condition having density ρ on ℤ− and λ on ℤ+, and a second class particle initially at the origin. For ρ&lt;λ, there is a shock and the second class particle moves with speed 1−λ−ρ. For large time t, we show that the position of the second class particle fluctuates on a t1/3 scale and determine its limiting law. We also obtain the limiting distribution of the number of steps made by the second class particle until time t.","lang":"eng"}],"external_id":{"isi":["000487763200001"],"arxiv":["1710.02323"]},"scopus_import":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2023-10-17T08:53:45Z","publication_identifier":{"issn":["0246-0203"]},"article_type":"original","year":"2019","oa_version":"Preprint","publisher":"Institute of Mathematical Statistics","isi":1,"publication":"Annales de l'institut Henri Poincare (B) Probability and Statistics","department":[{"_id":"LaEr"},{"_id":"JaMa"}],"quality_controlled":"1","intvolume":"        55","status":"public","page":"1203-1225","month":"09","date_created":"2018-12-11T11:44:29Z","project":[{"_id":"258DCDE6-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","grant_number":"338804","name":"Random matrices, universality and disordered quantum systems"},{"name":"Optimal Transport and Stochastic Dynamics","grant_number":"716117","_id":"256E75B8-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"}],"language":[{"iso":"eng"}],"doi":"10.1214/18-AIHP916","citation":{"short":"P. Ferrari, P. Ghosal, P. Nejjar, Annales de l’institut Henri Poincare (B) Probability and Statistics 55 (2019) 1203–1225.","apa":"Ferrari, P., Ghosal, P., &#38; Nejjar, P. (2019). Limit law of a second class particle in TASEP with non-random initial condition. <i>Annales de l’institut Henri Poincare (B) Probability and Statistics</i>. Institute of Mathematical Statistics. <a href=\"https://doi.org/10.1214/18-AIHP916\">https://doi.org/10.1214/18-AIHP916</a>","ama":"Ferrari P, Ghosal P, Nejjar P. Limit law of a second class particle in TASEP with non-random initial condition. <i>Annales de l’institut Henri Poincare (B) Probability and Statistics</i>. 2019;55(3):1203-1225. doi:<a href=\"https://doi.org/10.1214/18-AIHP916\">10.1214/18-AIHP916</a>","ieee":"P. Ferrari, P. Ghosal, and P. Nejjar, “Limit law of a second class particle in TASEP with non-random initial condition,” <i>Annales de l’institut Henri Poincare (B) Probability and Statistics</i>, vol. 55, no. 3. Institute of Mathematical Statistics, pp. 1203–1225, 2019.","ista":"Ferrari P, Ghosal P, Nejjar P. 2019. Limit law of a second class particle in TASEP with non-random initial condition. Annales de l’institut Henri Poincare (B) Probability and Statistics. 55(3), 1203–1225.","chicago":"Ferrari, Patrick, Promit Ghosal, and Peter Nejjar. “Limit Law of a Second Class Particle in TASEP with Non-Random Initial Condition.” <i>Annales de l’institut Henri Poincare (B) Probability and Statistics</i>. Institute of Mathematical Statistics, 2019. <a href=\"https://doi.org/10.1214/18-AIHP916\">https://doi.org/10.1214/18-AIHP916</a>.","mla":"Ferrari, Patrick, et al. “Limit Law of a Second Class Particle in TASEP with Non-Random Initial Condition.” <i>Annales de l’institut Henri Poincare (B) Probability and Statistics</i>, vol. 55, no. 3, Institute of Mathematical Statistics, 2019, pp. 1203–25, doi:<a href=\"https://doi.org/10.1214/18-AIHP916\">10.1214/18-AIHP916</a>."},"ec_funded":1,"title":"Limit law of a second class particle in TASEP with non-random initial condition","day":"25","type":"journal_article","author":[{"last_name":"Ferrari","first_name":"Patrick","full_name":"Ferrari, Patrick"},{"full_name":"Ghosal, Promit","first_name":"Promit","last_name":"Ghosal"},{"id":"4BF426E2-F248-11E8-B48F-1D18A9856A87","last_name":"Nejjar","full_name":"Nejjar, Peter","first_name":"Peter"}]},{"oa_version":"Preprint","year":"2019","article_type":"original","publication_identifier":{"issn":["2469-9950"],"eissn":["2469-9969"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2024-02-28T13:14:08Z","external_id":{"isi":["000498845700006"],"arxiv":["1907.13579"]},"scopus_import":"1","abstract":[{"lang":"eng","text":"Recent scanning tunneling microscopy experiments in NbN thin disordered superconducting films found an emergent inhomogeneity at the scale of tens of nanometers. This inhomogeneity is mirrored by an apparent dimensional crossover in the paraconductivity measured in transport above the superconducting critical temperature Tc. This behavior was interpreted in terms of an anomalous diffusion of fluctuating Cooper pairs that display a quasiconfinement (i.e., a slowing down of their diffusive dynamics) on length scales shorter than the inhomogeneity identified by tunneling experiments. Here, we assume this anomalous diffusive behavior of fluctuating Cooper pairs and calculate the effect of these fluctuations on the electron density of states above Tc. We find that the density of states is substantially suppressed up to temperatures well above Tc. This behavior, which is closely reminiscent of a pseudogap, only arises from the anomalous diffusion of fluctuating Cooper pairs in the absence of stable preformed pairs, setting the stage for an intermediate behavior between the two common paradigms in the superconducting-insulator transition, namely, the localization of Cooper pairs (the so-called bosonic scenario) and the breaking of Cooper pairs into unpaired electrons due to strong disorder (the so-called fermionic scenario)."}],"_id":"7200","date_published":"2019-11-25T00:00:00Z","article_number":"174518","issue":"17","article_processing_charge":"No","arxiv":1,"volume":100,"oa":1,"main_file_link":[{"url":"https://arxiv.org/abs/1907.13579","open_access":"1"}],"publication_status":"published","author":[{"id":"4115AF5C-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-7969-2729","full_name":"Brighi, Pietro","first_name":"Pietro","last_name":"Brighi"},{"first_name":"Marco","full_name":"Grilli, Marco","last_name":"Grilli"},{"first_name":"Brigitte","full_name":"Leridon, Brigitte","last_name":"Leridon"},{"last_name":"Caprara","first_name":"Sergio","full_name":"Caprara, Sergio"}],"type":"journal_article","day":"25","title":"Effect of anomalous diffusion of fluctuating Cooper pairs on the density of states of superconducting NbN thin films","citation":{"ama":"Brighi P, Grilli M, Leridon B, Caprara S. Effect of anomalous diffusion of fluctuating Cooper pairs on the density of states of superconducting NbN thin films. <i>Physical Review B</i>. 2019;100(17). doi:<a href=\"https://doi.org/10.1103/PhysRevB.100.174518\">10.1103/PhysRevB.100.174518</a>","apa":"Brighi, P., Grilli, M., Leridon, B., &#38; Caprara, S. (2019). Effect of anomalous diffusion of fluctuating Cooper pairs on the density of states of superconducting NbN thin films. <i>Physical Review B</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevB.100.174518\">https://doi.org/10.1103/PhysRevB.100.174518</a>","short":"P. Brighi, M. Grilli, B. Leridon, S. Caprara, Physical Review B 100 (2019).","mla":"Brighi, Pietro, et al. “Effect of Anomalous Diffusion of Fluctuating Cooper Pairs on the Density of States of Superconducting NbN Thin Films.” <i>Physical Review B</i>, vol. 100, no. 17, 174518, American Physical Society, 2019, doi:<a href=\"https://doi.org/10.1103/PhysRevB.100.174518\">10.1103/PhysRevB.100.174518</a>.","chicago":"Brighi, Pietro, Marco Grilli, Brigitte Leridon, and Sergio Caprara. “Effect of Anomalous Diffusion of Fluctuating Cooper Pairs on the Density of States of Superconducting NbN Thin Films.” <i>Physical Review B</i>. American Physical Society, 2019. <a href=\"https://doi.org/10.1103/PhysRevB.100.174518\">https://doi.org/10.1103/PhysRevB.100.174518</a>.","ista":"Brighi P, Grilli M, Leridon B, Caprara S. 2019. Effect of anomalous diffusion of fluctuating Cooper pairs on the density of states of superconducting NbN thin films. Physical Review B. 100(17), 174518.","ieee":"P. Brighi, M. Grilli, B. Leridon, and S. Caprara, “Effect of anomalous diffusion of fluctuating Cooper pairs on the density of states of superconducting NbN thin films,” <i>Physical Review B</i>, vol. 100, no. 17. American Physical Society, 2019."},"doi":"10.1103/PhysRevB.100.174518","language":[{"iso":"eng"}],"date_created":"2019-12-22T23:00:41Z","month":"11","status":"public","intvolume":"       100","quality_controlled":"1","department":[{"_id":"MaSe"}],"publication":"Physical Review B","isi":1,"publisher":"American Physical Society"},{"status":"public","publication":"International Conference for High Performance Computing, Networking, Storage and Analysis, SC","quality_controlled":"1","department":[{"_id":"DaAl"}],"isi":1,"publisher":"ACM","date_created":"2019-12-22T23:00:42Z","month":"11","doi":"10.1145/3295500.3356222","language":[{"iso":"eng"}],"project":[{"call_identifier":"H2020","_id":"268A44D6-B435-11E9-9278-68D0E5697425","name":"Elastic Coordination for Scalable Machine Learning","grant_number":"805223"}],"author":[{"last_name":"Renggli","full_name":"Renggli, Cedric","first_name":"Cedric"},{"last_name":"Ashkboos","full_name":"Ashkboos, Saleh","first_name":"Saleh","id":"0D0A9058-257B-11EA-A937-9341C3D8BC8A"},{"last_name":"Aghagolzadeh","full_name":"Aghagolzadeh, Mehdi","first_name":"Mehdi"},{"first_name":"Dan-Adrian","full_name":"Alistarh, Dan-Adrian","last_name":"Alistarh","orcid":"0000-0003-3650-940X","id":"4A899BFC-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Hoefler, Torsten","first_name":"Torsten","last_name":"Hoefler"}],"type":"conference","day":"17","title":"SparCML: High-performance sparse communication for machine learning","conference":{"end_date":"2019-11-19","start_date":"2019-11-17","name":"SC: Conference for High Performance Computing, Networking, Storage and Analysis","location":"Denver, CO, Unites States"},"citation":{"mla":"Renggli, Cedric, et al. “SparCML: High-Performance Sparse Communication for Machine Learning.” <i>International Conference for High Performance Computing, Networking, Storage and Analysis, SC</i>, a11, ACM, 2019, doi:<a href=\"https://doi.org/10.1145/3295500.3356222\">10.1145/3295500.3356222</a>.","chicago":"Renggli, Cedric, Saleh Ashkboos, Mehdi Aghagolzadeh, Dan-Adrian Alistarh, and Torsten Hoefler. “SparCML: High-Performance Sparse Communication for Machine Learning.” In <i>International Conference for High Performance Computing, Networking, Storage and Analysis, SC</i>. ACM, 2019. <a href=\"https://doi.org/10.1145/3295500.3356222\">https://doi.org/10.1145/3295500.3356222</a>.","ieee":"C. Renggli, S. Ashkboos, M. Aghagolzadeh, D.-A. Alistarh, and T. Hoefler, “SparCML: High-performance sparse communication for machine learning,” in <i>International Conference for High Performance Computing, Networking, Storage and Analysis, SC</i>, Denver, CO, Unites States, 2019.","ista":"Renggli C, Ashkboos S, Aghagolzadeh M, Alistarh D-A, Hoefler T. 2019. SparCML: High-performance sparse communication for machine learning. International Conference for High Performance Computing, Networking, Storage and Analysis, SC. SC: Conference for High Performance Computing, Networking, Storage and Analysis, a11.","ama":"Renggli C, Ashkboos S, Aghagolzadeh M, Alistarh D-A, Hoefler T. SparCML: High-performance sparse communication for machine learning. In: <i>International Conference for High Performance Computing, Networking, Storage and Analysis, SC</i>. ACM; 2019. doi:<a href=\"https://doi.org/10.1145/3295500.3356222\">10.1145/3295500.3356222</a>","apa":"Renggli, C., Ashkboos, S., Aghagolzadeh, M., Alistarh, D.-A., &#38; Hoefler, T. (2019). SparCML: High-performance sparse communication for machine learning. In <i>International Conference for High Performance Computing, Networking, Storage and Analysis, SC</i>. Denver, CO, Unites States: ACM. <a href=\"https://doi.org/10.1145/3295500.3356222\">https://doi.org/10.1145/3295500.3356222</a>","short":"C. Renggli, S. Ashkboos, M. Aghagolzadeh, D.-A. Alistarh, T. Hoefler, in:, International Conference for High Performance Computing, Networking, Storage and Analysis, SC, ACM, 2019."},"ec_funded":1,"oa":1,"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1802.08021"}],"publication_status":"published","_id":"7201","date_published":"2019-11-17T00:00:00Z","abstract":[{"text":"Applying machine learning techniques to the quickly growing data in science and industry requires highly-scalable algorithms. Large datasets are most commonly processed \"data parallel\" distributed across many nodes. Each node's contribution to the overall gradient is summed using a global allreduce. This allreduce is the single communication and thus scalability bottleneck for most machine learning workloads. We observe that frequently, many gradient values are (close to) zero, leading to sparse of sparsifyable communications. To exploit this insight, we analyze, design, and implement a set of communication-efficient protocols for sparse input data, in conjunction with efficient machine learning algorithms which can leverage these primitives. Our communication protocols generalize standard collective operations, by allowing processes to contribute arbitrary sparse input data vectors. Our generic communication library, SparCML1, extends MPI to support additional features, such as non-blocking (asynchronous) operations and low-precision data representations. As such, SparCML and its techniques will form the basis of future highly-scalable machine learning frameworks.","lang":"eng"}],"article_number":"a11","article_processing_charge":"No","arxiv":1,"publication_identifier":{"eissn":["21674337"],"isbn":["9781450362290"],"issn":["21674329"]},"scopus_import":"1","external_id":{"arxiv":["1802.08021"],"isi":["000545976800011"]},"date_updated":"2023-09-06T14:37:55Z","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","year":"2019","oa_version":"Preprint"},{"project":[{"grant_number":"725780","name":"Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development","call_identifier":"H2020","_id":"260018B0-B435-11E9-9278-68D0E5697425"},{"call_identifier":"FWF","_id":"264E56E2-B435-11E9-9278-68D0E5697425","name":"Molecular Mechanisms Regulating Gliogenesis in the Cerebral Cortex","grant_number":"M02416"}],"pmid":1,"doi":"10.7554/eLife.51381","ddc":["570"],"language":[{"iso":"eng"}],"title":"A stochastic framework of neurogenesis underlies the assembly of neocortical cytoarchitecture","citation":{"apa":"Llorca, A., Ciceri, G., Beattie, R. J., Wong, F. K., Diana, G., Serafeimidou-Pouliou, E., … Marín, O. (2019). A stochastic framework of neurogenesis underlies the assembly of neocortical cytoarchitecture. <i>ELife</i>. eLife Sciences Publications. <a href=\"https://doi.org/10.7554/eLife.51381\">https://doi.org/10.7554/eLife.51381</a>","ama":"Llorca A, Ciceri G, Beattie RJ, et al. A stochastic framework of neurogenesis underlies the assembly of neocortical cytoarchitecture. <i>eLife</i>. 2019;8. doi:<a href=\"https://doi.org/10.7554/eLife.51381\">10.7554/eLife.51381</a>","short":"A. Llorca, G. Ciceri, R.J. Beattie, F.K. Wong, G. Diana, E. Serafeimidou-Pouliou, M. Fernández-Otero, C. Streicher, S.J. Arnold, M. Meyer, S. Hippenmeyer, M. Maravall, O. Marín, ELife 8 (2019).","mla":"Llorca, Alfredo, et al. “A Stochastic Framework of Neurogenesis Underlies the Assembly of Neocortical Cytoarchitecture.” <i>ELife</i>, vol. 8, e51381, eLife Sciences Publications, 2019, doi:<a href=\"https://doi.org/10.7554/eLife.51381\">10.7554/eLife.51381</a>.","ista":"Llorca A, Ciceri G, Beattie RJ, Wong FK, Diana G, Serafeimidou-Pouliou E, Fernández-Otero M, Streicher C, Arnold SJ, Meyer M, Hippenmeyer S, Maravall M, Marín O. 2019. A stochastic framework of neurogenesis underlies the assembly of neocortical cytoarchitecture. eLife. 8, e51381.","ieee":"A. Llorca <i>et al.</i>, “A stochastic framework of neurogenesis underlies the assembly of neocortical cytoarchitecture,” <i>eLife</i>, vol. 8. eLife Sciences Publications, 2019.","chicago":"Llorca, Alfredo, Gabriele Ciceri, Robert J Beattie, Fong Kuan Wong, Giovanni Diana, Eleni Serafeimidou-Pouliou, Marian Fernández-Otero, et al. “A Stochastic Framework of Neurogenesis Underlies the Assembly of Neocortical Cytoarchitecture.” <i>ELife</i>. eLife Sciences Publications, 2019. <a href=\"https://doi.org/10.7554/eLife.51381\">https://doi.org/10.7554/eLife.51381</a>."},"ec_funded":1,"author":[{"full_name":"Llorca, Alfredo","first_name":"Alfredo","last_name":"Llorca"},{"full_name":"Ciceri, Gabriele","first_name":"Gabriele","last_name":"Ciceri"},{"last_name":"Beattie","first_name":"Robert J","full_name":"Beattie, Robert J","id":"2E26DF60-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8483-8753"},{"last_name":"Wong","full_name":"Wong, Fong Kuan","first_name":"Fong Kuan"},{"first_name":"Giovanni","full_name":"Diana, Giovanni","last_name":"Diana"},{"last_name":"Serafeimidou-Pouliou","first_name":"Eleni","full_name":"Serafeimidou-Pouliou, Eleni"},{"last_name":"Fernández-Otero","full_name":"Fernández-Otero, Marian","first_name":"Marian"},{"full_name":"Streicher, Carmen","first_name":"Carmen","last_name":"Streicher","id":"36BCB99C-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Arnold","first_name":"Sebastian J.","full_name":"Arnold, Sebastian J."},{"full_name":"Meyer, Martin","first_name":"Martin","last_name":"Meyer"},{"last_name":"Hippenmeyer","first_name":"Simon","full_name":"Hippenmeyer, Simon","orcid":"0000-0003-2279-1061","id":"37B36620-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Miguel","full_name":"Maravall, Miguel","last_name":"Maravall"},{"last_name":"Marín","first_name":"Oscar","full_name":"Marín, Oscar"}],"type":"journal_article","day":"18","isi":1,"publisher":"eLife Sciences Publications","status":"public","intvolume":"         8","publication":"eLife","department":[{"_id":"SiHi"}],"quality_controlled":"1","date_created":"2019-12-22T23:00:42Z","month":"11","publication_identifier":{"eissn":["2050084X"]},"external_id":{"pmid":["31736464"],"isi":["000508156800001"]},"scopus_import":"1","date_updated":"2023-09-06T14:38:39Z","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","has_accepted_license":"1","year":"2019","oa_version":"Published Version","article_type":"original","oa":1,"publication_status":"published","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"volume":8,"file_date_updated":"2020-07-14T12:47:53Z","article_processing_charge":"No","_id":"7202","abstract":[{"text":"The cerebral cortex contains multiple areas with distinctive cytoarchitectonical patterns, but the cellular mechanisms underlying the emergence of this diversity remain unclear. Here, we have investigated the neuronal output of individual progenitor cells in the developing mouse neocortex using a combination of methods that together circumvent the biases and limitations of individual approaches. Our experimental results indicate that progenitor cells generate pyramidal cell lineages with a wide range of sizes and laminar configurations. Mathematical modelling indicates that these outcomes are compatible with a stochastic model of cortical neurogenesis in which progenitor cells undergo a series of probabilistic decisions that lead to the specification of very heterogeneous progenies. Our findings support a mechanism for cortical neurogenesis whose flexibility would make it capable to generate the diverse cytoarchitectures that characterize distinct neocortical areas.","lang":"eng"}],"date_published":"2019-11-18T00:00:00Z","article_number":"e51381","file":[{"file_size":2960543,"creator":"dernst","file_name":"2019_eLife_Llorca.pdf","checksum":"b460ecc33e1a68265e7adea775021f3a","access_level":"open_access","date_updated":"2020-07-14T12:47:53Z","file_id":"7503","relation":"main_file","content_type":"application/pdf","date_created":"2020-02-18T15:19:26Z"}]},{"file_date_updated":"2020-07-14T12:47:53Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"volume":2,"publication_status":"published","oa":1,"article_number":"138","file":[{"date_created":"2019-12-23T13:39:30Z","content_type":"application/pdf","relation":"main_file","file_id":"7211","checksum":"d1a69bfe73767e4246f0a38e4e1554dd","date_updated":"2020-07-14T12:47:53Z","access_level":"open_access","file_name":"2019_CommBio_Tkadlec.pdf","creator":"dernst","file_size":1670274}],"date_published":"2019-04-23T00:00:00Z","_id":"7210","abstract":[{"lang":"eng","text":"The rate of biological evolution depends on the fixation probability and on the fixation time of new mutants. Intensive research has focused on identifying population structures that augment the fixation probability of advantageous mutants. But these amplifiers of natural selection typically increase fixation time. Here we study population structures that achieve a tradeoff between fixation probability and time. First, we show that no amplifiers can have an asymptotically lower absorption time than the well-mixed population. Then we design population structures that substantially augment the fixation probability with just a minor increase in fixation time. Finally, we show that those structures enable higher effective rate of evolution than the well-mixed population provided that the rate of generating advantageous mutants is relatively low. Our work sheds light on how population structure affects the rate of evolution. Moreover, our structures could be useful for lab-based, medical, or industrial applications of evolutionary optimization."}],"article_processing_charge":"No","external_id":{"isi":["000465425700006"],"pmid":["31044163"]},"scopus_import":"1","date_updated":"2023-09-07T13:19:22Z","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","publication_identifier":{"issn":["2399-3642"]},"article_type":"original","has_accepted_license":"1","year":"2019","oa_version":"Published Version","publication":"Communications Biology","department":[{"_id":"KrCh"}],"quality_controlled":"1","intvolume":"         2","status":"public","publisher":"Springer Nature","isi":1,"month":"04","date_created":"2019-12-23T13:36:50Z","language":[{"iso":"eng"}],"ddc":["000"],"doi":"10.1038/s42003-019-0373-y","project":[{"grant_number":"279307","name":"Quantitative Graph Games: Theory and Applications","call_identifier":"FP7","_id":"2581B60A-B435-11E9-9278-68D0E5697425"},{"_id":"2584A770-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","name":"Modern Graph Algorithmic Techniques in Formal Verification","grant_number":"P 23499-N23"},{"call_identifier":"FWF","_id":"25832EC2-B435-11E9-9278-68D0E5697425","name":"Rigorous Systems Engineering","grant_number":"S 11407_N23"}],"pmid":1,"related_material":{"record":[{"status":"public","relation":"part_of_dissertation","id":"7196"}]},"day":"23","author":[{"full_name":"Tkadlec, Josef","first_name":"Josef","last_name":"Tkadlec","orcid":"0000-0002-1097-9684","id":"3F24CCC8-F248-11E8-B48F-1D18A9856A87"},{"id":"49704004-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8943-0722","last_name":"Pavlogiannis","full_name":"Pavlogiannis, Andreas","first_name":"Andreas"},{"id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4561-241X","first_name":"Krishnendu","full_name":"Chatterjee, Krishnendu","last_name":"Chatterjee"},{"last_name":"Nowak","full_name":"Nowak, Martin A.","first_name":"Martin A."}],"type":"journal_article","citation":{"apa":"Tkadlec, J., Pavlogiannis, A., Chatterjee, K., &#38; Nowak, M. A. (2019). Population structure determines the tradeoff between fixation probability and fixation time. <i>Communications Biology</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s42003-019-0373-y\">https://doi.org/10.1038/s42003-019-0373-y</a>","ama":"Tkadlec J, Pavlogiannis A, Chatterjee K, Nowak MA. Population structure determines the tradeoff between fixation probability and fixation time. <i>Communications Biology</i>. 2019;2. doi:<a href=\"https://doi.org/10.1038/s42003-019-0373-y\">10.1038/s42003-019-0373-y</a>","short":"J. Tkadlec, A. Pavlogiannis, K. Chatterjee, M.A. Nowak, Communications Biology 2 (2019).","mla":"Tkadlec, Josef, et al. “Population Structure Determines the Tradeoff between Fixation Probability and Fixation Time.” <i>Communications Biology</i>, vol. 2, 138, Springer Nature, 2019, doi:<a href=\"https://doi.org/10.1038/s42003-019-0373-y\">10.1038/s42003-019-0373-y</a>.","ieee":"J. Tkadlec, A. Pavlogiannis, K. Chatterjee, and M. A. Nowak, “Population structure determines the tradeoff between fixation probability and fixation time,” <i>Communications Biology</i>, vol. 2. Springer Nature, 2019.","ista":"Tkadlec J, Pavlogiannis A, Chatterjee K, Nowak MA. 2019. Population structure determines the tradeoff between fixation probability and fixation time. Communications Biology. 2, 138.","chicago":"Tkadlec, Josef, Andreas Pavlogiannis, Krishnendu Chatterjee, and Martin A. Nowak. “Population Structure Determines the Tradeoff between Fixation Probability and Fixation Time.” <i>Communications Biology</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s42003-019-0373-y\">https://doi.org/10.1038/s42003-019-0373-y</a>."},"ec_funded":1,"title":"Population structure determines the tradeoff between fixation probability and fixation time"},{"language":[{"iso":"eng"}],"ddc":["570"],"doi":"10.1186/s12859-019-3208-4","citation":{"chicago":"Aganezov, Sergey, Ilya Zban, Vitalii Aksenov, Nikita Alexeev, and Michael C. Schatz. “Recovering Rearranged Cancer Chromosomes from Karyotype Graphs.” <i>BMC Bioinformatics</i>. BMC, 2019. <a href=\"https://doi.org/10.1186/s12859-019-3208-4\">https://doi.org/10.1186/s12859-019-3208-4</a>.","ieee":"S. Aganezov, I. Zban, V. Aksenov, N. Alexeev, and M. C. Schatz, “Recovering rearranged cancer chromosomes from karyotype graphs,” <i>BMC Bioinformatics</i>, vol. 20. BMC, 2019.","ista":"Aganezov S, Zban I, Aksenov V, Alexeev N, Schatz MC. 2019. Recovering rearranged cancer chromosomes from karyotype graphs. BMC Bioinformatics. 20, 641.","mla":"Aganezov, Sergey, et al. “Recovering Rearranged Cancer Chromosomes from Karyotype Graphs.” <i>BMC Bioinformatics</i>, vol. 20, 641, BMC, 2019, doi:<a href=\"https://doi.org/10.1186/s12859-019-3208-4\">10.1186/s12859-019-3208-4</a>.","short":"S. Aganezov, I. Zban, V. Aksenov, N. Alexeev, M.C. Schatz, BMC Bioinformatics 20 (2019).","ama":"Aganezov S, Zban I, Aksenov V, Alexeev N, Schatz MC. Recovering rearranged cancer chromosomes from karyotype graphs. <i>BMC Bioinformatics</i>. 2019;20. doi:<a href=\"https://doi.org/10.1186/s12859-019-3208-4\">10.1186/s12859-019-3208-4</a>","apa":"Aganezov, S., Zban, I., Aksenov, V., Alexeev, N., &#38; Schatz, M. C. (2019). Recovering rearranged cancer chromosomes from karyotype graphs. <i>BMC Bioinformatics</i>. BMC. <a href=\"https://doi.org/10.1186/s12859-019-3208-4\">https://doi.org/10.1186/s12859-019-3208-4</a>"},"title":"Recovering rearranged cancer chromosomes from karyotype graphs","day":"17","author":[{"full_name":"Aganezov, Sergey","first_name":"Sergey","last_name":"Aganezov"},{"last_name":"Zban","first_name":"Ilya","full_name":"Zban, Ilya"},{"id":"2980135A-F248-11E8-B48F-1D18A9856A87","last_name":"Aksenov","full_name":"Aksenov, Vitalii","first_name":"Vitalii"},{"first_name":"Nikita","full_name":"Alexeev, Nikita","last_name":"Alexeev"},{"last_name":"Schatz","first_name":"Michael C.","full_name":"Schatz, Michael C."}],"type":"journal_article","publisher":"BMC","isi":1,"quality_controlled":"1","department":[{"_id":"DaAl"}],"publication":"BMC Bioinformatics","intvolume":"        20","status":"public","month":"12","date_created":"2019-12-29T23:00:46Z","date_updated":"2023-09-06T14:51:06Z","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","external_id":{"isi":["000511618800007"]},"scopus_import":"1","publication_identifier":{"eissn":["14712105"]},"article_type":"original","year":"2019","has_accepted_license":"1","oa_version":"Published Version","publication_status":"published","oa":1,"file_date_updated":"2020-07-14T12:47:54Z","volume":20,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"article_processing_charge":"No","article_number":"641","file":[{"date_created":"2020-01-02T16:10:58Z","content_type":"application/pdf","relation":"main_file","file_id":"7221","checksum":"7a30357efdcf8f66587ed495c0927724","date_updated":"2020-07-14T12:47:54Z","access_level":"open_access","file_name":"2019_BMCBioinfo_Aganezov.pdf","file_size":1917374,"creator":"dernst"}],"date_published":"2019-12-17T00:00:00Z","_id":"7214","abstract":[{"lang":"eng","text":"Background: Many cancer genomes are extensively rearranged with highly aberrant chromosomal karyotypes. Structural and copy number variations in cancer genomes can be determined via abnormal mapping of sequenced reads to the reference genome. Recently it became possible to reconcile both of these types of large-scale variations into a karyotype graph representation of the rearranged cancer genomes. Such a representation, however, does not directly describe the linear and/or circular structure of the underlying rearranged cancer chromosomes, thus limiting possible analysis of cancer genomes somatic evolutionary process as well as functional genomic changes brought by the large-scale genome rearrangements.\r\n\r\nResults: Here we address the aforementioned limitation by introducing a novel methodological framework for recovering rearranged cancer chromosomes from karyotype graphs. For a cancer karyotype graph we formulate an Eulerian Decomposition Problem (EDP) of finding a collection of linear and/or circular rearranged cancer chromosomes that are determined by the graph. We derive and prove computational complexities for several variations of the EDP. We then demonstrate that Eulerian decomposition of the cancer karyotype graphs is not always unique and present the Consistent Contig Covering Problem (CCCP) of recovering unambiguous cancer contigs from the cancer karyotype graph, and describe a novel algorithm CCR capable of solving CCCP in polynomial time. We apply CCR on a prostate cancer dataset and demonstrate that it is capable of consistently recovering large cancer contigs even when underlying cancer genomes are highly rearranged.\r\n\r\nConclusions: CCR can recover rearranged cancer contigs from karyotype graphs thereby addressing existing limitation in inferring chromosomal structures of rearranged cancer genomes and advancing our understanding of both patient/cancer-specific as well as the overall genetic instability in cancer."}]},{"article_processing_charge":"No","month":"11","article_number":"8917514","abstract":[{"lang":"eng","text":"We present LiveTraVeL (Live Transit Vehicle Labeling), a real-time system to label a stream of noisy observations of transit vehicle trajectories with the transit routes they are serving (e.g., northbound bus #5). In order to scale efficiently to large transit networks, our system first retrieves a small set of candidate routes from a geometrically indexed data structure, then applies a fine-grained scoring step to choose the best match. Given that real-time data remains unavailable for the majority of the world’s transit agencies, these inferences can help feed a real-time map of a transit system’s trips, infer transit trip delays in real time, or measure and correct noisy transit tracking data. This system can run on vehicle observations from a variety of sources that don’t attach route information to vehicle observations, such as public imagery streams or user-contributed transit vehicle sightings.We abstract away the specifics of the sensing system and demonstrate the effectiveness of our system on a \"semisynthetic\" dataset of all New York City buses, where we simulate sensed trajectories by starting with fully labeled vehicle trajectories reported via the GTFS-Realtime protocol, removing the transit route IDs, and perturbing locations with synthetic noise. Using just the geometric shapes of the trajectories, we demonstrate that our system converges on the correct route ID within a few minutes, even after a vehicle switches from serving one trip to the next."}],"_id":"7216","date_published":"2019-11-28T00:00:00Z","date_created":"2019-12-29T23:00:47Z","publication_status":"published","publisher":"IEEE","isi":1,"publication":"2019 IEEE Intelligent Transportation Systems Conference","department":[{"_id":"HeEd"}],"quality_controlled":"1","status":"public","citation":{"ieee":"G. F. Osang, J. Cook, A. Fabrikant, and M. Gruteser, “LiveTraVeL: Real-time matching of transit vehicle trajectories to transit routes at scale,” in <i>2019 IEEE Intelligent Transportation Systems Conference</i>, Auckland, New Zealand, 2019.","ista":"Osang GF, Cook J, Fabrikant A, Gruteser M. 2019. LiveTraVeL: Real-time matching of transit vehicle trajectories to transit routes at scale. 2019 IEEE Intelligent Transportation Systems Conference. ITSC: Intelligent Transportation Systems Conference, 8917514.","chicago":"Osang, Georg F, James Cook, Alex Fabrikant, and Marco Gruteser. “LiveTraVeL: Real-Time Matching of Transit Vehicle Trajectories to Transit Routes at Scale.” In <i>2019 IEEE Intelligent Transportation Systems Conference</i>. IEEE, 2019. <a href=\"https://doi.org/10.1109/ITSC.2019.8917514\">https://doi.org/10.1109/ITSC.2019.8917514</a>.","mla":"Osang, Georg F., et al. “LiveTraVeL: Real-Time Matching of Transit Vehicle Trajectories to Transit Routes at Scale.” <i>2019 IEEE Intelligent Transportation Systems Conference</i>, 8917514, IEEE, 2019, doi:<a href=\"https://doi.org/10.1109/ITSC.2019.8917514\">10.1109/ITSC.2019.8917514</a>.","short":"G.F. Osang, J. Cook, A. Fabrikant, M. Gruteser, in:, 2019 IEEE Intelligent Transportation Systems Conference, IEEE, 2019.","apa":"Osang, G. F., Cook, J., Fabrikant, A., &#38; Gruteser, M. (2019). LiveTraVeL: Real-time matching of transit vehicle trajectories to transit routes at scale. In <i>2019 IEEE Intelligent Transportation Systems Conference</i>. Auckland, New Zealand: IEEE. <a href=\"https://doi.org/10.1109/ITSC.2019.8917514\">https://doi.org/10.1109/ITSC.2019.8917514</a>","ama":"Osang GF, Cook J, Fabrikant A, Gruteser M. LiveTraVeL: Real-time matching of transit vehicle trajectories to transit routes at scale. In: <i>2019 IEEE Intelligent Transportation Systems Conference</i>. IEEE; 2019. doi:<a href=\"https://doi.org/10.1109/ITSC.2019.8917514\">10.1109/ITSC.2019.8917514</a>"},"title":"LiveTraVeL: Real-time matching of transit vehicle trajectories to transit routes at scale","conference":{"end_date":"2019-10-30","start_date":"2019-10-27","name":"ITSC: Intelligent Transportation Systems Conference","location":"Auckland, New Zealand"},"day":"28","type":"conference","author":[{"id":"464B40D6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8882-5116","last_name":"Osang","full_name":"Osang, Georg F","first_name":"Georg F"},{"full_name":"Cook, James","first_name":"James","last_name":"Cook"},{"first_name":"Alex","full_name":"Fabrikant, Alex","last_name":"Fabrikant"},{"full_name":"Gruteser, Marco","first_name":"Marco","last_name":"Gruteser"}],"oa_version":"None","year":"2019","external_id":{"isi":["000521238102050"]},"scopus_import":"1","language":[{"iso":"eng"}],"date_updated":"2023-09-06T14:50:28Z","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","publication_identifier":{"isbn":["9781538670248"]},"doi":"10.1109/ITSC.2019.8917514"},{"citation":{"chicago":"Merrin, Jack. “Frontiers in Microfluidics, a Teaching Resource Review.” <i>Bioengineering</i>. MDPI, 2019. <a href=\"https://doi.org/10.3390/bioengineering6040109\">https://doi.org/10.3390/bioengineering6040109</a>.","ista":"Merrin J. 2019. Frontiers in microfluidics, a teaching resource review. Bioengineering. 6(4), 109.","ieee":"J. Merrin, “Frontiers in microfluidics, a teaching resource review,” <i>Bioengineering</i>, vol. 6, no. 4. MDPI, 2019.","mla":"Merrin, Jack. “Frontiers in Microfluidics, a Teaching Resource Review.” <i>Bioengineering</i>, vol. 6, no. 4, 109, MDPI, 2019, doi:<a href=\"https://doi.org/10.3390/bioengineering6040109\">10.3390/bioengineering6040109</a>.","short":"J. Merrin, Bioengineering 6 (2019).","ama":"Merrin J. Frontiers in microfluidics, a teaching resource review. <i>Bioengineering</i>. 2019;6(4). doi:<a href=\"https://doi.org/10.3390/bioengineering6040109\">10.3390/bioengineering6040109</a>","apa":"Merrin, J. (2019). Frontiers in microfluidics, a teaching resource review. <i>Bioengineering</i>. MDPI. <a href=\"https://doi.org/10.3390/bioengineering6040109\">https://doi.org/10.3390/bioengineering6040109</a>"},"title":"Frontiers in microfluidics, a teaching resource review","day":"03","type":"journal_article","author":[{"id":"4515C308-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5145-4609","first_name":"Jack","full_name":"Merrin, Jack","last_name":"Merrin"}],"pmid":1,"language":[{"iso":"eng"}],"doi":"10.3390/bioengineering6040109","ddc":["620"],"month":"12","date_created":"2020-01-05T23:00:45Z","publisher":"MDPI","isi":1,"publication":"Bioengineering","quality_controlled":"1","department":[{"_id":"NanoFab"}],"intvolume":"         6","status":"public","article_type":"review","oa_version":"Published Version","year":"2019","has_accepted_license":"1","external_id":{"isi":["000505590000024"],"pmid":["31816954"]},"scopus_import":"1","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","date_updated":"2023-09-06T14:52:49Z","publication_identifier":{"eissn":["23065354"]},"article_processing_charge":"Yes","issue":"4","file":[{"checksum":"80f1499e2a4caccdf3aa54b137fd99a0","access_level":"open_access","date_updated":"2020-07-14T12:47:54Z","file_size":2660780,"creator":"dernst","file_name":"2019_Bioengineering_Merrin.pdf","date_created":"2020-01-07T14:49:59Z","relation":"main_file","file_id":"7243","content_type":"application/pdf"}],"article_number":"109","_id":"7225","abstract":[{"text":"This is a literature teaching resource review for biologically inspired microfluidics courses\r\nor exploring the diverse applications of microfluidics. The structure is around key papers and model\r\norganisms. While courses gradually change over time, a focus remains on understanding how\r\nmicrofluidics has developed as well as what it can and cannot do for researchers. As a primary\r\nstarting point, we cover micro-fluid mechanics principles and microfabrication of devices. A variety\r\nof applications are discussed using model prokaryotic and eukaryotic organisms from the set\r\nof bacteria (Escherichia coli), trypanosomes (Trypanosoma brucei), yeast (Saccharomyces cerevisiae),\r\nslime molds (Physarum polycephalum), worms (Caenorhabditis elegans), flies (Drosophila melangoster),\r\nplants (Arabidopsis thaliana), and mouse immune cells (Mus musculus). Other engineering and\r\nbiochemical methods discussed include biomimetics, organ on a chip, inkjet, droplet microfluidics,\r\nbiotic games, and diagnostics. While we have not yet reached the end-all lab on a chip,\r\nmicrofluidics can still be used effectively for specific applications.","lang":"eng"}],"date_published":"2019-12-03T00:00:00Z","publication_status":"published","oa":1,"file_date_updated":"2020-07-14T12:47:54Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"volume":6},{"month":"12","date_created":"2020-01-05T23:00:46Z","quality_controlled":"1","department":[{"_id":"RoSe"}],"publication":"Journal of Mathematical Physics","status":"public","intvolume":"        60","publisher":"AIP Publishing","isi":1,"day":"01","type":"journal_article","author":[{"last_name":"Jaksic","full_name":"Jaksic, Vojkan","first_name":"Vojkan"},{"orcid":"0000-0002-6781-0521","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","full_name":"Seiringer, Robert","first_name":"Robert","last_name":"Seiringer"}],"citation":{"apa":"Jaksic, V., &#38; Seiringer, R. (2019). Introduction to the Special Collection: International Congress on Mathematical Physics (ICMP) 2018. <i>Journal of Mathematical Physics</i>. AIP Publishing. <a href=\"https://doi.org/10.1063/1.5138135\">https://doi.org/10.1063/1.5138135</a>","ama":"Jaksic V, Seiringer R. Introduction to the Special Collection: International Congress on Mathematical Physics (ICMP) 2018. <i>Journal of Mathematical Physics</i>. 2019;60(12). doi:<a href=\"https://doi.org/10.1063/1.5138135\">10.1063/1.5138135</a>","short":"V. Jaksic, R. Seiringer, Journal of Mathematical Physics 60 (2019).","mla":"Jaksic, Vojkan, and Robert Seiringer. “Introduction to the Special Collection: International Congress on Mathematical Physics (ICMP) 2018.” <i>Journal of Mathematical Physics</i>, vol. 60, no. 12, 123504, AIP Publishing, 2019, doi:<a href=\"https://doi.org/10.1063/1.5138135\">10.1063/1.5138135</a>.","ista":"Jaksic V, Seiringer R. 2019. Introduction to the Special Collection: International Congress on Mathematical Physics (ICMP) 2018. Journal of Mathematical Physics. 60(12), 123504.","ieee":"V. Jaksic and R. Seiringer, “Introduction to the Special Collection: International Congress on Mathematical Physics (ICMP) 2018,” <i>Journal of Mathematical Physics</i>, vol. 60, no. 12. AIP Publishing, 2019.","chicago":"Jaksic, Vojkan, and Robert Seiringer. “Introduction to the Special Collection: International Congress on Mathematical Physics (ICMP) 2018.” <i>Journal of Mathematical Physics</i>. AIP Publishing, 2019. <a href=\"https://doi.org/10.1063/1.5138135\">https://doi.org/10.1063/1.5138135</a>."},"title":"Introduction to the Special Collection: International Congress on Mathematical Physics (ICMP) 2018","language":[{"iso":"eng"}],"doi":"10.1063/1.5138135","ddc":["500"],"file":[{"relation":"main_file","file_id":"7244","content_type":"application/pdf","date_created":"2020-01-07T14:59:13Z","creator":"dernst","file_size":1025015,"file_name":"2019_JournalMathPhysics_Jaksic.pdf","checksum":"bbd12ad1999a9ad7ba4d3c6f2e579c22","access_level":"open_access","date_updated":"2020-07-14T12:47:54Z"}],"article_number":"123504","date_published":"2019-12-01T00:00:00Z","_id":"7226","issue":"12","article_processing_charge":"No","file_date_updated":"2020-07-14T12:47:54Z","volume":60,"publication_status":"published","oa":1,"article_type":"letter_note","year":"2019","oa_version":"Published Version","has_accepted_license":"1","date_updated":"2024-02-28T13:01:45Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","external_id":{"isi":["000505529800002"]},"scopus_import":"1","publication_identifier":{"issn":["00222488"]}},{"intvolume":"     11725","status":"public","department":[{"_id":"DaAl"}],"quality_controlled":"1","publication":"25th Anniversary of Euro-Par","isi":1,"publisher":"Springer Nature","date_created":"2020-01-05T23:00:46Z","month":"08","page":"317-333","doi":"10.1007/978-3-030-29400-7_23","language":[{"iso":"eng"}],"alternative_title":["LNCS"],"type":"conference","author":[{"last_name":"Koval","first_name":"Nikita","full_name":"Koval, Nikita","id":"2F4DB10C-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0003-3650-940X","id":"4A899BFC-F248-11E8-B48F-1D18A9856A87","last_name":"Alistarh","first_name":"Dan-Adrian","full_name":"Alistarh, Dan-Adrian"},{"full_name":"Elizarov, Roman","first_name":"Roman","last_name":"Elizarov"}],"day":"13","conference":{"location":"Göttingen, Germany","name":"Euro-Par: European Conference on Parallel Processing","start_date":"2019-08-26","end_date":"2019-08-30"},"title":"Scalable FIFO channels for programming via communicating sequential processes","citation":{"mla":"Koval, Nikita, et al. “Scalable FIFO Channels for Programming via Communicating Sequential Processes.” <i>25th Anniversary of Euro-Par</i>, vol. 11725, Springer Nature, 2019, pp. 317–33, doi:<a href=\"https://doi.org/10.1007/978-3-030-29400-7_23\">10.1007/978-3-030-29400-7_23</a>.","ieee":"N. Koval, D.-A. Alistarh, and R. Elizarov, “Scalable FIFO channels for programming via communicating sequential processes,” in <i>25th Anniversary of Euro-Par</i>, Göttingen, Germany, 2019, vol. 11725, pp. 317–333.","ista":"Koval N, Alistarh D-A, Elizarov R. 2019. Scalable FIFO channels for programming via communicating sequential processes. 25th Anniversary of Euro-Par. Euro-Par: European Conference on Parallel Processing, LNCS, vol. 11725, 317–333.","chicago":"Koval, Nikita, Dan-Adrian Alistarh, and Roman Elizarov. “Scalable FIFO Channels for Programming via Communicating Sequential Processes.” In <i>25th Anniversary of Euro-Par</i>, 11725:317–33. Springer Nature, 2019. <a href=\"https://doi.org/10.1007/978-3-030-29400-7_23\">https://doi.org/10.1007/978-3-030-29400-7_23</a>.","apa":"Koval, N., Alistarh, D.-A., &#38; Elizarov, R. (2019). Scalable FIFO channels for programming via communicating sequential processes. In <i>25th Anniversary of Euro-Par</i> (Vol. 11725, pp. 317–333). Göttingen, Germany: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-030-29400-7_23\">https://doi.org/10.1007/978-3-030-29400-7_23</a>","ama":"Koval N, Alistarh D-A, Elizarov R. Scalable FIFO channels for programming via communicating sequential processes. In: <i>25th Anniversary of Euro-Par</i>. Vol 11725. Springer Nature; 2019:317-333. doi:<a href=\"https://doi.org/10.1007/978-3-030-29400-7_23\">10.1007/978-3-030-29400-7_23</a>","short":"N. Koval, D.-A. Alistarh, R. Elizarov, in:, 25th Anniversary of Euro-Par, Springer Nature, 2019, pp. 317–333."},"volume":11725,"publication_status":"published","_id":"7228","abstract":[{"text":"Traditional concurrent programming involves manipulating shared mutable state. Alternatives to this programming style are communicating sequential processes (CSP) and actor models, which share data via explicit communication. These models have been known for almost half a century, and have recently had started to gain significant traction among modern programming languages. The common abstraction for communication between several processes is the channel. Although channels are similar to producer-consumer data structures, they have different semantics and support additional operations, such as the select expression. Despite their growing popularity, most known implementations of channels use lock-based data structures and can be rather inefficient.\r\n\r\nIn this paper, we present the first efficient lock-free algorithm for implementing a communication channel for CSP programming. We provide implementations and experimental results in the Kotlin and Go programming languages. Our new algorithm outperforms existing implementations on many workloads, while providing non-blocking progress guarantee. Our design can serve as an example of how to construct general communication data structures for CSP and actor models. ","lang":"eng"}],"date_published":"2019-08-13T00:00:00Z","article_processing_charge":"No","publication_identifier":{"eissn":["1611-3349"],"isbn":["978-3-0302-9399-4"],"issn":["0302-9743"]},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","date_updated":"2023-09-06T14:53:59Z","scopus_import":"1","external_id":{"isi":["000851061400023"]},"year":"2019","oa_version":"None"},{"project":[{"call_identifier":"H2020","_id":"260C2330-B435-11E9-9278-68D0E5697425","name":"ISTplus - Postdoctoral Fellowships","grant_number":"754411"}],"doi":"10.1007/978-3-030-35802-0_18","language":[{"iso":"eng"}],"conference":{"name":"GD: Graph Drawing and Network Visualization","end_date":"2019-09-20","start_date":"2019-09-17","location":"Prague, Czech Republic"},"title":"Extending simple drawings","ec_funded":1,"citation":{"ama":"Arroyo Guevara AM, Derka M, Parada I. Extending simple drawings. In: <i>27th International Symposium on Graph Drawing and Network Visualization</i>. Vol 11904. Springer Nature; 2019:230-243. doi:<a href=\"https://doi.org/10.1007/978-3-030-35802-0_18\">10.1007/978-3-030-35802-0_18</a>","apa":"Arroyo Guevara, A. M., Derka, M., &#38; Parada, I. (2019). Extending simple drawings. In <i>27th International Symposium on Graph Drawing and Network Visualization</i> (Vol. 11904, pp. 230–243). Prague, Czech Republic: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-030-35802-0_18\">https://doi.org/10.1007/978-3-030-35802-0_18</a>","short":"A.M. Arroyo Guevara, M. Derka, I. Parada, in:, 27th International Symposium on Graph Drawing and Network Visualization, Springer Nature, 2019, pp. 230–243.","mla":"Arroyo Guevara, Alan M., et al. “Extending Simple Drawings.” <i>27th International Symposium on Graph Drawing and Network Visualization</i>, vol. 11904, Springer Nature, 2019, pp. 230–43, doi:<a href=\"https://doi.org/10.1007/978-3-030-35802-0_18\">10.1007/978-3-030-35802-0_18</a>.","chicago":"Arroyo Guevara, Alan M, Martin Derka, and Irene Parada. “Extending Simple Drawings.” In <i>27th International Symposium on Graph Drawing and Network Visualization</i>, 11904:230–43. Springer Nature, 2019. <a href=\"https://doi.org/10.1007/978-3-030-35802-0_18\">https://doi.org/10.1007/978-3-030-35802-0_18</a>.","ista":"Arroyo Guevara AM, Derka M, Parada I. 2019. Extending simple drawings. 27th International Symposium on Graph Drawing and Network Visualization. GD: Graph Drawing and Network Visualization, LNCS, vol. 11904, 230–243.","ieee":"A. M. Arroyo Guevara, M. Derka, and I. Parada, “Extending simple drawings,” in <i>27th International Symposium on Graph Drawing and Network Visualization</i>, Prague, Czech Republic, 2019, vol. 11904, pp. 230–243."},"alternative_title":["LNCS"],"author":[{"id":"3207FDC6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-2401-8670","first_name":"Alan M","full_name":"Arroyo Guevara, Alan M","last_name":"Arroyo Guevara"},{"last_name":"Derka","full_name":"Derka, Martin","first_name":"Martin"},{"last_name":"Parada","full_name":"Parada, Irene","first_name":"Irene"}],"type":"conference","day":"28","isi":1,"publisher":"Springer Nature","status":"public","intvolume":"     11904","quality_controlled":"1","department":[{"_id":"UlWa"}],"publication":"27th International Symposium on Graph Drawing and Network Visualization","page":"230-243","date_created":"2020-01-05T23:00:47Z","month":"11","publication_identifier":{"isbn":["978-3-0303-5801-3"],"issn":["0302-9743"],"eissn":["1611-3349"]},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","date_updated":"2023-09-06T14:56:00Z","external_id":{"isi":["000612918800018"],"arxiv":["1908.08129"]},"scopus_import":"1","oa_version":"Preprint","year":"2019","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1908.08129"}],"oa":1,"publication_status":"published","volume":11904,"article_processing_charge":"No","arxiv":1,"_id":"7230","abstract":[{"text":"Simple drawings of graphs are those in which each pair of edges share at most one point, either a common endpoint or a proper crossing. In this paper we study the problem of extending a simple drawing D(G) of a graph G by inserting a set of edges from the complement of G into D(G) such that the result is a simple drawing. In the context of rectilinear drawings, the problem is trivial. For pseudolinear drawings, the existence of such an extension follows from Levi’s enlargement lemma. In contrast, we prove that deciding if a given set of edges can be inserted into a simple drawing is NP-complete. Moreover, we show that the maximization version of the problem is APX-hard. We also present a polynomial-time algorithm for deciding whether one edge uv can be inserted into D(G) when {u,v} is a dominating set for the graph G.","lang":"eng"}],"date_published":"2019-11-28T00:00:00Z"},{"page":"123-141","month":"08","date_created":"2020-01-05T23:00:47Z","publisher":"Springer Nature","isi":1,"publication":"17th International Conference on Formal Modeling and Analysis of Timed Systems","quality_controlled":"1","department":[{"_id":"ToHe"}],"status":"public","intvolume":"     11750","citation":{"apa":"Kong, H., Bartocci, E., Jiang, Y., &#38; Henzinger, T. A. (2019). Piecewise robust barrier tubes for nonlinear hybrid systems with uncertainty. In <i>17th International Conference on Formal Modeling and Analysis of Timed Systems</i> (Vol. 11750, pp. 123–141). Amsterdam, The Netherlands: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-030-29662-9_8\">https://doi.org/10.1007/978-3-030-29662-9_8</a>","ama":"Kong H, Bartocci E, Jiang Y, Henzinger TA. Piecewise robust barrier tubes for nonlinear hybrid systems with uncertainty. In: <i>17th International Conference on Formal Modeling and Analysis of Timed Systems</i>. Vol 11750. Springer Nature; 2019:123-141. doi:<a href=\"https://doi.org/10.1007/978-3-030-29662-9_8\">10.1007/978-3-030-29662-9_8</a>","short":"H. Kong, E. Bartocci, Y. Jiang, T.A. Henzinger, in:, 17th International Conference on Formal Modeling and Analysis of Timed Systems, Springer Nature, 2019, pp. 123–141.","mla":"Kong, Hui, et al. “Piecewise Robust Barrier Tubes for Nonlinear Hybrid Systems with Uncertainty.” <i>17th International Conference on Formal Modeling and Analysis of Timed Systems</i>, vol. 11750, Springer Nature, 2019, pp. 123–41, doi:<a href=\"https://doi.org/10.1007/978-3-030-29662-9_8\">10.1007/978-3-030-29662-9_8</a>.","ista":"Kong H, Bartocci E, Jiang Y, Henzinger TA. 2019. Piecewise robust barrier tubes for nonlinear hybrid systems with uncertainty. 17th International Conference on Formal Modeling and Analysis of Timed Systems. FORMATS: Formal Modeling and Analysis of Timed Systems, LNCS, vol. 11750, 123–141.","ieee":"H. Kong, E. Bartocci, Y. Jiang, and T. A. Henzinger, “Piecewise robust barrier tubes for nonlinear hybrid systems with uncertainty,” in <i>17th International Conference on Formal Modeling and Analysis of Timed Systems</i>, Amsterdam, The Netherlands, 2019, vol. 11750, pp. 123–141.","chicago":"Kong, Hui, Ezio Bartocci, Yu Jiang, and Thomas A Henzinger. “Piecewise Robust Barrier Tubes for Nonlinear Hybrid Systems with Uncertainty.” In <i>17th International Conference on Formal Modeling and Analysis of Timed Systems</i>, 11750:123–41. Springer Nature, 2019. <a href=\"https://doi.org/10.1007/978-3-030-29662-9_8\">https://doi.org/10.1007/978-3-030-29662-9_8</a>."},"title":"Piecewise robust barrier tubes for nonlinear hybrid systems with uncertainty","conference":{"start_date":"2019-08-27","end_date":"2019-08-29","name":"FORMATS: Formal Modeling and Analysis of Timed Systems","location":"Amsterdam, The Netherlands"},"day":"13","author":[{"full_name":"Kong, Hui","first_name":"Hui","last_name":"Kong","orcid":"0000-0002-3066-6941","id":"3BDE25AA-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Ezio","full_name":"Bartocci, Ezio","last_name":"Bartocci"},{"first_name":"Yu","full_name":"Jiang, Yu","last_name":"Jiang"},{"id":"40876CD8-F248-11E8-B48F-1D18A9856A87","orcid":"0000−0002−2985−7724","last_name":"Henzinger","full_name":"Henzinger, Thomas A","first_name":"Thomas A"}],"type":"conference","alternative_title":["LNCS"],"project":[{"name":"Rigorous Systems Engineering","grant_number":"S 11407_N23","_id":"25832EC2-B435-11E9-9278-68D0E5697425","call_identifier":"FWF"},{"call_identifier":"FWF","_id":"25863FF4-B435-11E9-9278-68D0E5697425","grant_number":"S11407","name":"Game Theory"},{"_id":"25F42A32-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","grant_number":"Z211","name":"The Wittgenstein Prize"}],"language":[{"iso":"eng"}],"doi":"10.1007/978-3-030-29662-9_8","arxiv":1,"article_processing_charge":"No","date_published":"2019-08-13T00:00:00Z","_id":"7231","abstract":[{"lang":"eng","text":"Piecewise Barrier Tubes (PBT) is a new technique for flowpipe overapproximation for nonlinear systems with polynomial dynamics, which leverages a combination of barrier certificates. PBT has advantages over traditional time-step based methods in dealing with those nonlinear dynamical systems in which there is a large difference in speed between trajectories, producing an overapproximation that is time independent. However, the existing approach for PBT is not efficient due to the application of interval methods for enclosure-box computation, and it can only deal with continuous dynamical systems without uncertainty. In this paper, we extend the approach with the ability to handle both continuous and hybrid dynamical systems with uncertainty that can reside in parameters and/or noise. We also improve the efficiency of the method significantly, by avoiding the use of interval-based methods for the enclosure-box computation without loosing soundness. We have developed a C++ prototype implementing the proposed approach and we evaluate it on several benchmarks. The experiments show that our approach is more efficient and precise than other methods in the literature."}],"publication_status":"published","oa":1,"main_file_link":[{"url":"https://arxiv.org/abs/1907.11514","open_access":"1"}],"volume":11750,"oa_version":"Preprint","year":"2019","scopus_import":"1","external_id":{"isi":["000611677700008"],"arxiv":["1907.11514"]},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","date_updated":"2023-09-06T14:55:15Z","publication_identifier":{"issn":["0302-9743"],"isbn":["978-3-0302-9661-2"],"eissn":["1611-3349"]}},{"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","date_updated":"2023-09-06T14:57:17Z","external_id":{"isi":["000611677700004"]},"scopus_import":"1","publication_identifier":{"eissn":["1611-3349"],"issn":["0302-9743"],"isbn":["978-3-0302-9661-2"]},"year":"2019","oa_version":"None","volume":11750,"publication_status":"published","date_published":"2019-08-13T00:00:00Z","_id":"7232","abstract":[{"lang":"eng","text":"We present Mixed-time Signal Temporal Logic (STL−MX), a specification formalism which extends STL by capturing the discrete/ continuous time duality found in many cyber-physical systems (CPS), as well as mixed-signal electronic designs. In STL−MX, properties of components with continuous dynamics are expressed in STL, while specifications of components with discrete dynamics are written in LTL. To combine the two layers, we evaluate formulas on two traces, discrete- and continuous-time, and introduce two interface operators that map signals, properties and their satisfaction signals across the two time domains. We show that STL-mx has the expressive power of STL supplemented with an implicit T-periodic clock signal. We develop and implement an algorithm for monitoring STL-mx formulas and illustrate the approach using a mixed-signal example. "}],"article_processing_charge":"No","language":[{"iso":"eng"}],"doi":"10.1007/978-3-030-29662-9_4","project":[{"name":"Rigorous Systems Engineering","grant_number":"S 11407_N23","_id":"25832EC2-B435-11E9-9278-68D0E5697425","call_identifier":"FWF"},{"_id":"25F42A32-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","grant_number":"Z211","name":"The Wittgenstein Prize"}],"day":"13","alternative_title":["LNCS"],"type":"conference","author":[{"last_name":"Ferrere","full_name":"Ferrere, Thomas","first_name":"Thomas","orcid":"0000-0001-5199-3143","id":"40960E6E-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Oded","full_name":"Maler, Oded","last_name":"Maler"},{"full_name":"Nickovic, Dejan","first_name":"Dejan","last_name":"Nickovic","id":"41BCEE5C-F248-11E8-B48F-1D18A9856A87"}],"citation":{"chicago":"Ferrere, Thomas, Oded Maler, and Dejan Nickovic. “Mixed-Time Signal Temporal Logic.” In <i>17th International Conference on Formal Modeling and Analysis of Timed Systems</i>, 11750:59–75. Springer Nature, 2019. <a href=\"https://doi.org/10.1007/978-3-030-29662-9_4\">https://doi.org/10.1007/978-3-030-29662-9_4</a>.","ieee":"T. Ferrere, O. Maler, and D. Nickovic, “Mixed-time signal temporal logic,” in <i>17th International Conference on Formal Modeling and Analysis of Timed Systems</i>, Amsterdam, The Netherlands, 2019, vol. 11750, pp. 59–75.","ista":"Ferrere T, Maler O, Nickovic D. 2019. Mixed-time signal temporal logic. 17th International Conference on Formal Modeling and Analysis of Timed Systems. FORMATS: Formal Modeling and Anaysis of Timed Systems, LNCS, vol. 11750, 59–75.","mla":"Ferrere, Thomas, et al. “Mixed-Time Signal Temporal Logic.” <i>17th International Conference on Formal Modeling and Analysis of Timed Systems</i>, vol. 11750, Springer Nature, 2019, pp. 59–75, doi:<a href=\"https://doi.org/10.1007/978-3-030-29662-9_4\">10.1007/978-3-030-29662-9_4</a>.","short":"T. Ferrere, O. Maler, D. Nickovic, in:, 17th International Conference on Formal Modeling and Analysis of Timed Systems, Springer Nature, 2019, pp. 59–75.","ama":"Ferrere T, Maler O, Nickovic D. Mixed-time signal temporal logic. In: <i>17th International Conference on Formal Modeling and Analysis of Timed Systems</i>. Vol 11750. Springer Nature; 2019:59-75. doi:<a href=\"https://doi.org/10.1007/978-3-030-29662-9_4\">10.1007/978-3-030-29662-9_4</a>","apa":"Ferrere, T., Maler, O., &#38; Nickovic, D. (2019). Mixed-time signal temporal logic. In <i>17th International Conference on Formal Modeling and Analysis of Timed Systems</i> (Vol. 11750, pp. 59–75). Amsterdam, The Netherlands: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-030-29662-9_4\">https://doi.org/10.1007/978-3-030-29662-9_4</a>"},"conference":{"end_date":"2019-08-29","start_date":"2019-08-27","name":"FORMATS: Formal Modeling and Anaysis of Timed Systems","location":"Amsterdam, The Netherlands"},"title":"Mixed-time signal temporal logic","department":[{"_id":"ToHe"}],"quality_controlled":"1","publication":"17th International Conference on Formal Modeling and Analysis of Timed Systems","status":"public","intvolume":"     11750","publisher":"Springer Nature","isi":1,"month":"08","date_created":"2020-01-05T23:00:48Z","page":"59-75"},{"doi":"10.1364/NLO.2019.NM2A.5","publication_identifier":{"isbn":["9781557528209"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","language":[{"iso":"eng"}],"date_updated":"2023-10-17T12:14:46Z","scopus_import":"1","year":"2019","oa_version":"None","type":"conference","author":[{"orcid":"0000-0001-6249-5860","id":"3B82B0F8-F248-11E8-B48F-1D18A9856A87","first_name":"Alfredo R","full_name":"Rueda Sanchez, Alfredo R","last_name":"Rueda Sanchez"},{"full_name":"Sedlmeir, Florian","first_name":"Florian","last_name":"Sedlmeir"},{"full_name":"Leuchs, Gerd","first_name":"Gerd","last_name":"Leuchs"},{"full_name":"Kumari, Madhuri","first_name":"Madhuri","last_name":"Kumari"},{"full_name":"Schwefel, Harald G.L.","first_name":"Harald G.L.","last_name":"Schwefel"}],"day":"15","conference":{"name":"NLO: Nonlinear Optics","start_date":"2019-07-15","end_date":"2019-07-19","location":"Waikoloa Beach, Hawaii (HI), United States"},"title":"Resonant electro-optic frequency comb generation in lithium niobate disk resonator inside a microwave cavity","citation":{"ista":"Rueda Sanchez AR, Sedlmeir F, Leuchs G, Kumari M, Schwefel HGL. 2019. Resonant electro-optic frequency comb generation in lithium niobate disk resonator inside a microwave cavity. Nonlinear Optics, OSA Technical Digest. NLO: Nonlinear Optics, NM2A.5.","ieee":"A. R. Rueda Sanchez, F. Sedlmeir, G. Leuchs, M. Kumari, and H. G. L. Schwefel, “Resonant electro-optic frequency comb generation in lithium niobate disk resonator inside a microwave cavity,” in <i>Nonlinear Optics, OSA Technical Digest</i>, Waikoloa Beach, Hawaii (HI), United States, 2019.","chicago":"Rueda Sanchez, Alfredo R, Florian Sedlmeir, Gerd Leuchs, Madhuri Kumari, and Harald G.L. Schwefel. “Resonant Electro-Optic Frequency Comb Generation in Lithium Niobate Disk Resonator inside a Microwave Cavity.” In <i>Nonlinear Optics, OSA Technical Digest</i>. Optica  Publishing Group, 2019. <a href=\"https://doi.org/10.1364/NLO.2019.NM2A.5\">https://doi.org/10.1364/NLO.2019.NM2A.5</a>.","mla":"Rueda Sanchez, Alfredo R., et al. “Resonant Electro-Optic Frequency Comb Generation in Lithium Niobate Disk Resonator inside a Microwave Cavity.” <i>Nonlinear Optics, OSA Technical Digest</i>, NM2A.5, Optica  Publishing Group, 2019, doi:<a href=\"https://doi.org/10.1364/NLO.2019.NM2A.5\">10.1364/NLO.2019.NM2A.5</a>.","short":"A.R. Rueda Sanchez, F. Sedlmeir, G. Leuchs, M. Kumari, H.G.L. Schwefel, in:, Nonlinear Optics, OSA Technical Digest, Optica  Publishing Group, 2019.","apa":"Rueda Sanchez, A. R., Sedlmeir, F., Leuchs, G., Kumari, M., &#38; Schwefel, H. G. L. (2019). Resonant electro-optic frequency comb generation in lithium niobate disk resonator inside a microwave cavity. In <i>Nonlinear Optics, OSA Technical Digest</i>. Waikoloa Beach, Hawaii (HI), United States: Optica  Publishing Group. <a href=\"https://doi.org/10.1364/NLO.2019.NM2A.5\">https://doi.org/10.1364/NLO.2019.NM2A.5</a>","ama":"Rueda Sanchez AR, Sedlmeir F, Leuchs G, Kumari M, Schwefel HGL. Resonant electro-optic frequency comb generation in lithium niobate disk resonator inside a microwave cavity. In: <i>Nonlinear Optics, OSA Technical Digest</i>. Optica  Publishing Group; 2019. doi:<a href=\"https://doi.org/10.1364/NLO.2019.NM2A.5\">10.1364/NLO.2019.NM2A.5</a>"},"status":"public","department":[{"_id":"JoFi"}],"quality_controlled":"1","publication":"Nonlinear Optics, OSA Technical Digest","publication_status":"published","publisher":"Optica  Publishing Group","_id":"7233","date_published":"2019-07-15T00:00:00Z","abstract":[{"lang":"eng","text":"We demonstrate electro-optic frequency comb generation using a doubly resonant system comprising a whispering gallery mode disk resonator made of lithium niobate mounted inside a three dimensional copper cavity. We observe 180 sidebands centred at 1550 nm."}],"date_created":"2020-01-05T23:00:48Z","article_number":"NM2A.5","month":"07","article_processing_charge":"No"},{"ddc":["530","541","540"],"doi":"10.1039/c9ee01453e","language":[{"iso":"eng"}],"title":"Singlet oxygen from cation driven superoxide disproportionation and consequences for aprotic metal–O2 batteries","citation":{"short":"E. Mourad, Y.K. Petit, R. Spezia, A. Samojlov, F.F. Summa, C. Prehal, C. Leypold, N. Mahne, C. Slugovc, O. Fontaine, S. Brutti, S.A. Freunberger, Energy &#38; Environmental Science 12 (2019) 2559–2568.","ama":"Mourad E, Petit YK, Spezia R, et al. Singlet oxygen from cation driven superoxide disproportionation and consequences for aprotic metal–O2 batteries. <i>Energy &#38; Environmental Science</i>. 2019;12(8):2559-2568. doi:<a href=\"https://doi.org/10.1039/c9ee01453e\">10.1039/c9ee01453e</a>","apa":"Mourad, E., Petit, Y. K., Spezia, R., Samojlov, A., Summa, F. F., Prehal, C., … Freunberger, S. A. (2019). Singlet oxygen from cation driven superoxide disproportionation and consequences for aprotic metal–O2 batteries. <i>Energy &#38; Environmental Science</i>. RSC. <a href=\"https://doi.org/10.1039/c9ee01453e\">https://doi.org/10.1039/c9ee01453e</a>","chicago":"Mourad, Eléonore, Yann K. Petit, Riccardo Spezia, Aleksej Samojlov, Francesco F. Summa, Christian Prehal, Christian Leypold, et al. “Singlet Oxygen from Cation Driven Superoxide Disproportionation and Consequences for Aprotic Metal–O2 Batteries.” <i>Energy &#38; Environmental Science</i>. RSC, 2019. <a href=\"https://doi.org/10.1039/c9ee01453e\">https://doi.org/10.1039/c9ee01453e</a>.","ista":"Mourad E, Petit YK, Spezia R, Samojlov A, Summa FF, Prehal C, Leypold C, Mahne N, Slugovc C, Fontaine O, Brutti S, Freunberger SA. 2019. Singlet oxygen from cation driven superoxide disproportionation and consequences for aprotic metal–O2 batteries. Energy &#38; Environmental Science. 12(8), 2559–2568.","ieee":"E. Mourad <i>et al.</i>, “Singlet oxygen from cation driven superoxide disproportionation and consequences for aprotic metal–O2 batteries,” <i>Energy &#38; Environmental Science</i>, vol. 12, no. 8. RSC, pp. 2559–2568, 2019.","mla":"Mourad, Eléonore, et al. “Singlet Oxygen from Cation Driven Superoxide Disproportionation and Consequences for Aprotic Metal–O2 Batteries.” <i>Energy &#38; Environmental Science</i>, vol. 12, no. 8, RSC, 2019, pp. 2559–68, doi:<a href=\"https://doi.org/10.1039/c9ee01453e\">10.1039/c9ee01453e</a>."},"author":[{"last_name":"Mourad","full_name":"Mourad, Eléonore","first_name":"Eléonore"},{"full_name":"Petit, Yann K.","first_name":"Yann K.","last_name":"Petit"},{"first_name":"Riccardo","full_name":"Spezia, Riccardo","last_name":"Spezia"},{"first_name":"Aleksej","full_name":"Samojlov, Aleksej","last_name":"Samojlov"},{"last_name":"Summa","first_name":"Francesco F.","full_name":"Summa, Francesco F."},{"full_name":"Prehal, Christian","first_name":"Christian","last_name":"Prehal"},{"last_name":"Leypold","first_name":"Christian","full_name":"Leypold, Christian"},{"last_name":"Mahne","full_name":"Mahne, Nika","first_name":"Nika"},{"last_name":"Slugovc","full_name":"Slugovc, Christian","first_name":"Christian"},{"first_name":"Olivier","full_name":"Fontaine, Olivier","last_name":"Fontaine"},{"first_name":"Sergio","full_name":"Brutti, Sergio","last_name":"Brutti"},{"orcid":"0000-0003-2902-5319","id":"A8CA28E6-CE23-11E9-AD2D-EC27E6697425","last_name":"Freunberger","full_name":"Freunberger, Stefan Alexander","first_name":"Stefan Alexander"}],"type":"journal_article","day":"01","publisher":"RSC","intvolume":"        12","status":"public","quality_controlled":"1","publication":"Energy & Environmental Science","page":"2559-2568","date_created":"2020-01-15T07:18:04Z","extern":"1","month":"08","publication_identifier":{"issn":["1754-5692","1754-5706"]},"date_updated":"2021-01-12T08:12:41Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","has_accepted_license":"1","year":"2019","oa_version":"Published Version","article_type":"original","oa":1,"publication_status":"published","volume":12,"tmp":{"short":"CC BY-NC (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","image":"/images/cc_by_nc.png","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)"},"file_date_updated":"2020-07-14T12:47:55Z","issue":"8","article_processing_charge":"No","abstract":[{"text":"Aprotic alkali metal–oxygen batteries require reversible formation of metal superoxide or peroxide on cycling. Severe parasitic reactions cause poor rechargeability, efficiency, and cycle life and have been shown to be caused by singlet oxygen (1O2) that forms at all stages of cycling. However, its formation mechanism remains unclear. We show that disproportionation of superoxide, the product or intermediate on discharge and charge, to peroxide and oxygen is responsible for 1O2 formation. While the overall reaction is driven by the stability of peroxide and thus favored by stronger Lewis acidic cations such as Li+, the 1O2 fraction is enhanced by weak Lewis acids such as organic cations. Concurrently, the metal peroxide yield drops with increasing 1O2. The results explain a major parasitic pathway during cell cycling and the growing severity in K–, Na–, and Li–O2 cells based on the growing propensity for disproportionation. High capacities and rates with peroxides are now realized to require solution processes, which form peroxide or release O2via disproportionation. The results therefore establish the central dilemma that disproportionation is required for high capacity but also responsible for irreversible reactions. Highly reversible cell operation requires hence finding reaction routes that avoid disproportionation.","lang":"eng"}],"_id":"7275","date_published":"2019-08-01T00:00:00Z","file":[{"checksum":"94d4cfb2ab0b4c90ef76a7f3cc811feb","access_level":"open_access","date_updated":"2020-07-14T12:47:55Z","creator":"dernst","file_size":2888027,"file_name":"2019_EnergyEnvironScienc_Mourad.pdf","date_created":"2020-01-30T16:11:05Z","relation":"main_file","file_id":"7424","content_type":"application/pdf"}]},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2021-01-12T08:12:42Z","publication_identifier":{"issn":["1433-7851"]},"article_type":"original","year":"2019","oa_version":"Published Version","has_accepted_license":"1","file_date_updated":"2020-07-14T12:47:55Z","tmp":{"name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","short":"CC BY-NC-ND (4.0)"},"volume":58,"publication_status":"published","oa":1,"file":[{"file_size":952737,"creator":"dernst","file_name":"2019_AngewChemie_Petit.pdf","checksum":"9620b6a511a910d7abe1f26c42dc7f83","access_level":"open_access","date_updated":"2020-07-14T12:47:55Z","file_id":"7356","relation":"main_file","content_type":"application/pdf","date_created":"2020-01-22T16:16:54Z"}],"abstract":[{"text":"Singlet oxygen (1O2) causes a major fraction of the parasitic chemistry during the cycling of non‐aqueous alkali metal‐O2 batteries and also contributes to interfacial reactivity of transition‐metal oxide intercalation compounds. We introduce DABCOnium, the mono alkylated form of 1,4‐diazabicyclo[2.2.2]octane (DABCO), as an efficient 1O2 quencher with an unusually high oxidative stability of ca. 4.2 V vs. Li/Li+. Previous quenchers are strongly Lewis basic amines with too low oxidative stability. DABCOnium is an ionic liquid, non‐volatile, highly soluble in the electrolyte, stable against superoxide and peroxide, and compatible with lithium metal. The electrochemical stability covers the required range for metal–O2 batteries and greatly reduces 1O2 related parasitic chemistry as demonstrated for the Li–O2 cell.","lang":"eng"}],"_id":"7276","date_published":"2019-05-13T00:00:00Z","article_processing_charge":"No","issue":"20","language":[{"iso":"eng"}],"ddc":["540"],"doi":"10.1002/anie.201901869","day":"13","author":[{"full_name":"Petit, Yann K.","first_name":"Yann K.","last_name":"Petit"},{"last_name":"Leypold","full_name":"Leypold, Christian","first_name":"Christian"},{"first_name":"Nika","full_name":"Mahne, Nika","last_name":"Mahne"},{"first_name":"Eléonore","full_name":"Mourad, Eléonore","last_name":"Mourad"},{"first_name":"Lukas","full_name":"Schafzahl, Lukas","last_name":"Schafzahl"},{"first_name":"Christian","full_name":"Slugovc, Christian","last_name":"Slugovc"},{"last_name":"Borisov","full_name":"Borisov, Sergey M.","first_name":"Sergey M."},{"last_name":"Freunberger","full_name":"Freunberger, Stefan Alexander","first_name":"Stefan Alexander","id":"A8CA28E6-CE23-11E9-AD2D-EC27E6697425","orcid":"0000-0003-2902-5319"}],"type":"journal_article","citation":{"mla":"Petit, Yann K., et al. “DABCOnium: An Efficient and High-Voltage Stable Singlet Oxygen Quencher for Metal-O2 Cells.” <i>Angewandte Chemie International Edition</i>, vol. 58, no. 20, Wiley, 2019, pp. 6535–39, doi:<a href=\"https://doi.org/10.1002/anie.201901869\">10.1002/anie.201901869</a>.","chicago":"Petit, Yann K., Christian Leypold, Nika Mahne, Eléonore Mourad, Lukas Schafzahl, Christian Slugovc, Sergey M. Borisov, and Stefan Alexander Freunberger. “DABCOnium: An Efficient and High-Voltage Stable Singlet Oxygen Quencher for Metal-O2 Cells.” <i>Angewandte Chemie International Edition</i>. Wiley, 2019. <a href=\"https://doi.org/10.1002/anie.201901869\">https://doi.org/10.1002/anie.201901869</a>.","ista":"Petit YK, Leypold C, Mahne N, Mourad E, Schafzahl L, Slugovc C, Borisov SM, Freunberger SA. 2019. DABCOnium: An efficient and high-voltage stable singlet oxygen quencher for metal-O2 cells. Angewandte Chemie International Edition. 58(20), 6535–6539.","ieee":"Y. K. Petit <i>et al.</i>, “DABCOnium: An efficient and high-voltage stable singlet oxygen quencher for metal-O2 cells,” <i>Angewandte Chemie International Edition</i>, vol. 58, no. 20. Wiley, pp. 6535–6539, 2019.","ama":"Petit YK, Leypold C, Mahne N, et al. DABCOnium: An efficient and high-voltage stable singlet oxygen quencher for metal-O2 cells. <i>Angewandte Chemie International Edition</i>. 2019;58(20):6535-6539. doi:<a href=\"https://doi.org/10.1002/anie.201901869\">10.1002/anie.201901869</a>","apa":"Petit, Y. K., Leypold, C., Mahne, N., Mourad, E., Schafzahl, L., Slugovc, C., … Freunberger, S. A. (2019). DABCOnium: An efficient and high-voltage stable singlet oxygen quencher for metal-O2 cells. <i>Angewandte Chemie International Edition</i>. Wiley. <a href=\"https://doi.org/10.1002/anie.201901869\">https://doi.org/10.1002/anie.201901869</a>","short":"Y.K. Petit, C. Leypold, N. Mahne, E. Mourad, L. Schafzahl, C. Slugovc, S.M. Borisov, S.A. Freunberger, Angewandte Chemie International Edition 58 (2019) 6535–6539."},"title":"DABCOnium: An efficient and high-voltage stable singlet oxygen quencher for metal-O2 cells","publication":"Angewandte Chemie International Edition","quality_controlled":"1","status":"public","intvolume":"        58","publisher":"Wiley","month":"05","extern":"1","date_created":"2020-01-15T07:19:27Z","page":"6535-6539"},{"_id":"7280","date_published":"2019-03-26T00:00:00Z","abstract":[{"lang":"eng","text":"Non-aqueous lithium-oxygen batteries cycle by forming lithium peroxide during discharge and oxidizing it during recharge. The significant problem of oxidizing the solid insulating lithium peroxide can greatly be facilitated by incorporating redox mediators that shuttle electron-holes between the porous substrate and lithium peroxide. Redox mediator stability is thus key for energy efficiency, reversibility, and cycle life. However, the gradual deactivation of redox mediators during repeated cycling has not conclusively been explained. Here, we show that organic redox mediators are predominantly decomposed by singlet oxygen that forms during cycling. Their reaction with superoxide, previously assumed to mainly trigger their degradation, peroxide, and dioxygen, is orders of magnitude slower in comparison. The reduced form of the mediator is markedly more reactive towards singlet oxygen than the oxidized form, from which we derive reaction mechanisms supported by density functional theory calculations. Redox mediators must thus be designed for stability against singlet oxygen."}],"article_number":"1380","file":[{"date_created":"2020-01-22T15:58:54Z","relation":"main_file","file_id":"7355","content_type":"application/pdf","access_level":"open_access","date_updated":"2020-07-14T12:47:55Z","checksum":"123dd33e7f26761c82c74e10811a1e4d","file_size":1003676,"creator":"dernst","file_name":"2019_NatureComm_Kwak.pdf"}],"article_processing_charge":"No","volume":10,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"file_date_updated":"2020-07-14T12:47:55Z","oa":1,"publication_status":"published","has_accepted_license":"1","year":"2019","oa_version":"Published Version","article_type":"original","publication_identifier":{"issn":["2041-1723"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2021-01-12T08:12:44Z","date_created":"2020-01-15T12:12:26Z","extern":"1","month":"03","intvolume":"        10","status":"public","quality_controlled":"1","publication":"Nature Communications","publisher":"Springer Nature","type":"journal_article","author":[{"last_name":"Kwak","first_name":"Won-Jin","full_name":"Kwak, Won-Jin"},{"first_name":"Hun","full_name":"Kim, Hun","last_name":"Kim"},{"full_name":"Petit, Yann K.","first_name":"Yann K.","last_name":"Petit"},{"last_name":"Leypold","full_name":"Leypold, Christian","first_name":"Christian"},{"last_name":"Nguyen","first_name":"Trung Thien","full_name":"Nguyen, Trung Thien"},{"last_name":"Mahne","first_name":"Nika","full_name":"Mahne, Nika"},{"full_name":"Redfern, Paul","first_name":"Paul","last_name":"Redfern"},{"first_name":"Larry A.","full_name":"Curtiss, Larry A.","last_name":"Curtiss"},{"first_name":"Hun-Gi","full_name":"Jung, Hun-Gi","last_name":"Jung"},{"first_name":"Sergey M.","full_name":"Borisov, Sergey M.","last_name":"Borisov"},{"last_name":"Freunberger","full_name":"Freunberger, Stefan Alexander","first_name":"Stefan Alexander","id":"A8CA28E6-CE23-11E9-AD2D-EC27E6697425","orcid":"0000-0003-2902-5319"},{"last_name":"Sun","first_name":"Yang-Kook","full_name":"Sun, Yang-Kook"}],"day":"26","title":"Deactivation of redox mediators in lithium-oxygen batteries by singlet oxygen","citation":{"short":"W.-J. Kwak, H. Kim, Y.K. Petit, C. Leypold, T.T. Nguyen, N. Mahne, P. Redfern, L.A. Curtiss, H.-G. Jung, S.M. Borisov, S.A. Freunberger, Y.-K. Sun, Nature Communications 10 (2019).","ama":"Kwak W-J, Kim H, Petit YK, et al. Deactivation of redox mediators in lithium-oxygen batteries by singlet oxygen. <i>Nature Communications</i>. 2019;10. doi:<a href=\"https://doi.org/10.1038/s41467-019-09399-0\">10.1038/s41467-019-09399-0</a>","apa":"Kwak, W.-J., Kim, H., Petit, Y. K., Leypold, C., Nguyen, T. T., Mahne, N., … Sun, Y.-K. (2019). Deactivation of redox mediators in lithium-oxygen batteries by singlet oxygen. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-019-09399-0\">https://doi.org/10.1038/s41467-019-09399-0</a>","chicago":"Kwak, Won-Jin, Hun Kim, Yann K. Petit, Christian Leypold, Trung Thien Nguyen, Nika Mahne, Paul Redfern, et al. “Deactivation of Redox Mediators in Lithium-Oxygen Batteries by Singlet Oxygen.” <i>Nature Communications</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s41467-019-09399-0\">https://doi.org/10.1038/s41467-019-09399-0</a>.","ista":"Kwak W-J, Kim H, Petit YK, Leypold C, Nguyen TT, Mahne N, Redfern P, Curtiss LA, Jung H-G, Borisov SM, Freunberger SA, Sun Y-K. 2019. Deactivation of redox mediators in lithium-oxygen batteries by singlet oxygen. Nature Communications. 10, 1380.","ieee":"W.-J. Kwak <i>et al.</i>, “Deactivation of redox mediators in lithium-oxygen batteries by singlet oxygen,” <i>Nature Communications</i>, vol. 10. Springer Nature, 2019.","mla":"Kwak, Won-Jin, et al. “Deactivation of Redox Mediators in Lithium-Oxygen Batteries by Singlet Oxygen.” <i>Nature Communications</i>, vol. 10, 1380, Springer Nature, 2019, doi:<a href=\"https://doi.org/10.1038/s41467-019-09399-0\">10.1038/s41467-019-09399-0</a>."},"doi":"10.1038/s41467-019-09399-0","ddc":["540"],"language":[{"iso":"eng"}]}]