---
_id: '392'
abstract:
- lang: eng
  text: We used femtosecond optical pump-probe spectroscopy to study the photoinduced
    change in reflectivity of thin films of the electron-doped cuprate La2-xCexCuO4
    (LCCO) with dopings of x=0.08 (underdoped) and x=0.11 (optimally doped). Above
    Tc, we observe fluence-dependent relaxation rates that begin at a temperature
    similar to the one where transport measurements first show signatures of antiferromagnetic
    correlations. Upon suppressing superconductivity with a magnetic field, it is
    found that the fluence and temperature dependence of relaxation rates are consistent
    with bimolecular recombination of electrons and holes across a gap (2ΔAF) originating
    from antiferromagnetic correlations which comprise the pseudogap in electron-doped
    cuprates. This can be used to learn about coupling between electrons and high-energy
    (ω&gt;2ΔAF) excitations in these compounds and set limits on the time scales on
    which antiferromagnetic correlations are static.
acknowledgement: Optical pump-probe work was supported by the Gordon and Betty Moore
  Foundation's EPiQS initiative through Grant No. GBMF4540. Materials growth and characterization
  was supported by AFOSR FA95501410332 and NSF DMR1410665.
author:
- first_name: Inna
  full_name: Vishik, Inna
  last_name: Vishik
- first_name: Fahad
  full_name: Mahmood, Fahad
  last_name: Mahmood
- first_name: Zhanybek
  full_name: Alpichshev, Zhanybek
  id: 45E67A2A-F248-11E8-B48F-1D18A9856A87
  last_name: Alpichshev
  orcid: 0000-0002-7183-5203
- first_name: Nuh
  full_name: Gedik, Nuh
  last_name: Gedik
- first_name: Joshu
  full_name: Higgins, Joshu
  last_name: Higgins
- first_name: Richard
  full_name: Greene, Richard
  last_name: Greene
citation:
  ama: Vishik I, Mahmood F, Alpichshev Z, Gedik N, Higgins J, Greene R. Ultrafast
    dynamics in the presence of antiferromagnetic correlations in electron doped cuprate
    La2 xCexCuO4±δ. <i>Physical Review B</i>. 2017;95(11). doi:<a href="https://doi.org/10.1103/PhysRevB.95.115125">10.1103/PhysRevB.95.115125</a>
  apa: Vishik, I., Mahmood, F., Alpichshev, Z., Gedik, N., Higgins, J., &#38; Greene,
    R. (2017). Ultrafast dynamics in the presence of antiferromagnetic correlations
    in electron doped cuprate La2 xCexCuO4±δ. <i>Physical Review B</i>. American Physical
    Society. <a href="https://doi.org/10.1103/PhysRevB.95.115125">https://doi.org/10.1103/PhysRevB.95.115125</a>
  chicago: Vishik, Inna, Fahad Mahmood, Zhanybek Alpichshev, Nuh Gedik, Joshu Higgins,
    and Richard Greene. “Ultrafast Dynamics in the Presence of Antiferromagnetic Correlations
    in Electron Doped Cuprate La2 XCexCuO4±δ.” <i>Physical Review B</i>. American
    Physical Society, 2017. <a href="https://doi.org/10.1103/PhysRevB.95.115125">https://doi.org/10.1103/PhysRevB.95.115125</a>.
  ieee: I. Vishik, F. Mahmood, Z. Alpichshev, N. Gedik, J. Higgins, and R. Greene,
    “Ultrafast dynamics in the presence of antiferromagnetic correlations in electron
    doped cuprate La2 xCexCuO4±δ,” <i>Physical Review B</i>, vol. 95, no. 11. American
    Physical Society, 2017.
  ista: Vishik I, Mahmood F, Alpichshev Z, Gedik N, Higgins J, Greene R. 2017. Ultrafast
    dynamics in the presence of antiferromagnetic correlations in electron doped cuprate
    La2 xCexCuO4±δ. Physical Review B. 95(11).
  mla: Vishik, Inna, et al. “Ultrafast Dynamics in the Presence of Antiferromagnetic
    Correlations in Electron Doped Cuprate La2 XCexCuO4±δ.” <i>Physical Review B</i>,
    vol. 95, no. 11, American Physical Society, 2017, doi:<a href="https://doi.org/10.1103/PhysRevB.95.115125">10.1103/PhysRevB.95.115125</a>.
  short: I. Vishik, F. Mahmood, Z. Alpichshev, N. Gedik, J. Higgins, R. Greene, Physical
    Review B 95 (2017).
date_created: 2018-12-11T11:46:13Z
date_published: 2017-03-13T00:00:00Z
date_updated: 2021-01-12T07:53:12Z
day: '13'
doi: 10.1103/PhysRevB.95.115125
extern: '1'
intvolume: '        95'
issue: '11'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://dspace.mit.edu/handle/1721.1/109835
month: '03'
oa: 1
oa_version: None
publication: Physical Review B
publication_status: published
publisher: American Physical Society
publist_id: '7437'
status: public
title: Ultrafast dynamics in the presence of antiferromagnetic correlations in electron
  doped cuprate La2 xCexCuO4±δ
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 95
year: '2017'
...
---
_id: '393'
abstract:
- lang: eng
  text: 'We use a three-pulse ultrafast optical spectroscopy to study the relaxation
    processes in a frustrated Mott insulator Na2IrO3. By being able to independently
    produce the out-of-equilibrium bound states (excitons) of doublons and holons
    with the first pulse and suppress the underlying antiferromagnetic order with
    the second one, we were able to elucidate the relaxation mechanism of quasiparticles
    in this system. By observing the difference in the exciton dynamics in the magnetically
    ordered and disordered phases we found that the mass of this quasiparticle is
    mostly determined by its interaction with the surrounding spins. '
acknowledgement: "Z.A. gratefully acknowledges discussions with P. A. Lee and A. Kemper.
  A conversation with J. Zaanen was instrumental in clarifying the physical picture
  described in this paper. We would also like to thank A. Kogar for thoroughly reading
  the manuscript and making valuable comments. This work was supported by Army Research
  Office Grant No. W911NF-15-1-0128 and Gordon and Betty Moore Foundation EPiQS Initiative
  through Grant No. GBMF4540 (time resolved optical spectroscopy), Skoltech, as part
  of the Skoltech NGP program (theory) and National Science Foundation Grant No. DMR-1265162
  (material growth).\r\n\r\n"
author:
- first_name: Zhanybek
  full_name: Alpichshev, Zhanybek
  id: 45E67A2A-F248-11E8-B48F-1D18A9856A87
  last_name: Alpichshev
  orcid: 0000-0002-7183-5203
- first_name: Edbert
  full_name: Sie, Edbert
  last_name: Sie
- first_name: Fahad
  full_name: Mahmood, Fahad
  last_name: Mahmood
- first_name: Gang
  full_name: Cao, Gang
  last_name: Cao
- first_name: Nuh
  full_name: Gedik, Nuh
  last_name: Gedik
citation:
  ama: Alpichshev Z, Sie E, Mahmood F, Cao G, Gedik N. Origin of the exciton mass
    in the frustrated Mott insulator Na2IrO3. <i>Physical Review B</i>. 2017;96(23).
    doi:<a href="https://doi.org/10.1103/PhysRevB.96.235141">10.1103/PhysRevB.96.235141</a>
  apa: Alpichshev, Z., Sie, E., Mahmood, F., Cao, G., &#38; Gedik, N. (2017). Origin
    of the exciton mass in the frustrated Mott insulator Na2IrO3. <i>Physical Review
    B</i>. American Physical Society. <a href="https://doi.org/10.1103/PhysRevB.96.235141">https://doi.org/10.1103/PhysRevB.96.235141</a>
  chicago: Alpichshev, Zhanybek, Edbert Sie, Fahad Mahmood, Gang Cao, and Nuh Gedik.
    “Origin of the Exciton Mass in the Frustrated Mott Insulator Na2IrO3.” <i>Physical
    Review B</i>. American Physical Society, 2017. <a href="https://doi.org/10.1103/PhysRevB.96.235141">https://doi.org/10.1103/PhysRevB.96.235141</a>.
  ieee: Z. Alpichshev, E. Sie, F. Mahmood, G. Cao, and N. Gedik, “Origin of the exciton
    mass in the frustrated Mott insulator Na2IrO3,” <i>Physical Review B</i>, vol.
    96, no. 23. American Physical Society, 2017.
  ista: Alpichshev Z, Sie E, Mahmood F, Cao G, Gedik N. 2017. Origin of the exciton
    mass in the frustrated Mott insulator Na2IrO3. Physical Review B. 96(23).
  mla: Alpichshev, Zhanybek, et al. “Origin of the Exciton Mass in the Frustrated
    Mott Insulator Na2IrO3.” <i>Physical Review B</i>, vol. 96, no. 23, American Physical
    Society, 2017, doi:<a href="https://doi.org/10.1103/PhysRevB.96.235141">10.1103/PhysRevB.96.235141</a>.
  short: Z. Alpichshev, E. Sie, F. Mahmood, G. Cao, N. Gedik, Physical Review B 96
    (2017).
date_created: 2018-12-11T11:46:13Z
date_published: 2017-12-26T00:00:00Z
date_updated: 2021-01-12T07:53:16Z
day: '26'
doi: 10.1103/PhysRevB.96.235141
extern: '1'
intvolume: '        96'
issue: '23'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://dspace.mit.edu/handle/1721.1/114259
month: '12'
oa: 1
oa_version: None
publication: Physical Review B
publication_status: published
publisher: American Physical Society
publist_id: '7436'
status: public
title: Origin of the exciton mass in the frustrated Mott insulator Na2IrO3
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 96
year: '2017'
...
---
_id: '424'
abstract:
- lang: eng
  text: 'We show that very weak topological assumptions are enough to ensure the existence
    of a Helly-type theorem. More precisely, we show that for any non-negative integers
    b and d there exists an integer h(b, d) such that the following holds. If F is
    a finite family of subsets of Rd such that βi(∩G)≤b for any G⊊F and every 0 ≤
    i ≤ [d/2]-1 then F has Helly number at most h(b, d). Here βi denotes the reduced
    Z2-Betti numbers (with singular homology). These topological conditions are sharp:
    not controlling any of these [d/2] first Betti numbers allow for families with
    unbounded Helly number. Our proofs combine homological non-embeddability results
    with a Ramsey-based approach to build, given an arbitrary simplicial complex K,
    some well-behaved chain map C*(K)→C*(Rd).'
author:
- first_name: Xavier
  full_name: Goaoc, Xavier
  last_name: Goaoc
- first_name: Pavel
  full_name: Paták, Pavel
  last_name: Paták
- first_name: Zuzana
  full_name: Patakova, Zuzana
  last_name: Patakova
  orcid: 0000-0002-3975-1683
- first_name: Martin
  full_name: Tancer, Martin
  last_name: Tancer
  orcid: 0000-0002-1191-6714
- first_name: Uli
  full_name: Wagner, Uli
  id: 36690CA2-F248-11E8-B48F-1D18A9856A87
  last_name: Wagner
  orcid: 0000-0002-1494-0568
citation:
  ama: 'Goaoc X, Paták P, Patakova Z, Tancer M, Wagner U. Bounding helly numbers via
    betti numbers. In: Loebl M, Nešetřil J, Thomas R, eds. <i>A Journey through Discrete
    Mathematics: A Tribute to Jiri Matousek</i>. A Journey Through Discrete Mathematics.
    Springer; 2017:407-447. doi:<a href="https://doi.org/10.1007/978-3-319-44479-6_17">10.1007/978-3-319-44479-6_17</a>'
  apa: 'Goaoc, X., Paták, P., Patakova, Z., Tancer, M., &#38; Wagner, U. (2017). Bounding
    helly numbers via betti numbers. In M. Loebl, J. Nešetřil, &#38; R. Thomas (Eds.),
    <i>A Journey through Discrete Mathematics: A Tribute to Jiri Matousek</i> (pp.
    407–447). Springer. <a href="https://doi.org/10.1007/978-3-319-44479-6_17">https://doi.org/10.1007/978-3-319-44479-6_17</a>'
  chicago: 'Goaoc, Xavier, Pavel Paták, Zuzana Patakova, Martin Tancer, and Uli Wagner.
    “Bounding Helly Numbers via Betti Numbers.” In <i>A Journey through Discrete Mathematics:
    A Tribute to Jiri Matousek</i>, edited by Martin Loebl, Jaroslav Nešetřil, and
    Robin Thomas, 407–47. A Journey Through Discrete Mathematics. Springer, 2017.
    <a href="https://doi.org/10.1007/978-3-319-44479-6_17">https://doi.org/10.1007/978-3-319-44479-6_17</a>.'
  ieee: 'X. Goaoc, P. Paták, Z. Patakova, M. Tancer, and U. Wagner, “Bounding helly
    numbers via betti numbers,” in <i>A Journey through Discrete Mathematics: A Tribute
    to Jiri Matousek</i>, M. Loebl, J. Nešetřil, and R. Thomas, Eds. Springer, 2017,
    pp. 407–447.'
  ista: 'Goaoc X, Paták P, Patakova Z, Tancer M, Wagner U. 2017.Bounding helly numbers
    via betti numbers. In: A Journey through Discrete Mathematics: A Tribute to Jiri
    Matousek. , 407–447.'
  mla: 'Goaoc, Xavier, et al. “Bounding Helly Numbers via Betti Numbers.” <i>A Journey
    through Discrete Mathematics: A Tribute to Jiri Matousek</i>, edited by Martin
    Loebl et al., Springer, 2017, pp. 407–47, doi:<a href="https://doi.org/10.1007/978-3-319-44479-6_17">10.1007/978-3-319-44479-6_17</a>.'
  short: 'X. Goaoc, P. Paták, Z. Patakova, M. Tancer, U. Wagner, in:, M. Loebl, J.
    Nešetřil, R. Thomas (Eds.), A Journey through Discrete Mathematics: A Tribute
    to Jiri Matousek, Springer, 2017, pp. 407–447.'
date_created: 2018-12-11T11:46:24Z
date_published: 2017-10-06T00:00:00Z
date_updated: 2024-02-28T12:59:37Z
day: '06'
department:
- _id: UlWa
doi: 10.1007/978-3-319-44479-6_17
editor:
- first_name: Martin
  full_name: Loebl, Martin
  last_name: Loebl
- first_name: Jaroslav
  full_name: Nešetřil, Jaroslav
  last_name: Nešetřil
- first_name: Robin
  full_name: Thomas, Robin
  last_name: Thomas
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1310.4613v3
month: '10'
oa: 1
oa_version: Published Version
page: 407 - 447
publication: 'A Journey through Discrete Mathematics: A Tribute to Jiri Matousek'
publication_identifier:
  isbn:
  - 978-331944479-6
publication_status: published
publisher: Springer
publist_id: '7399'
quality_controlled: '1'
related_material:
  record:
  - id: '1512'
    relation: earlier_version
    status: public
scopus_import: 1
series_title: A Journey Through Discrete Mathematics
status: public
title: Bounding helly numbers via betti numbers
type: book_chapter
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
year: '2017'
...
---
_id: '431'
abstract:
- lang: eng
  text: 'Parallel implementations of stochastic gradient descent (SGD) have received
    significant research attention, thanks to its excellent scalability properties.
    A fundamental barrier when parallelizing SGD is the high bandwidth cost of communicating
    gradient updates between nodes; consequently, several lossy compresion heuristics
    have been proposed, by which nodes only communicate quantized gradients. Although
    effective in practice, these heuristics do not always converge. In this paper,
    we propose Quantized SGD (QSGD), a family of compression schemes with convergence
    guarantees and good practical performance. QSGD allows the user to smoothly trade
    off communication bandwidth and convergence time: nodes can adjust the number
    of bits sent per iteration, at the cost of possibly higher variance. We show that
    this trade-off is inherent, in the sense that improving it past some threshold
    would violate information-theoretic lower bounds. QSGD guarantees convergence
    for convex and non-convex objectives, under asynchrony, and can be extended to
    stochastic variance-reduced techniques. When applied to training deep neural networks
    for image classification and automated speech recognition, QSGD leads to significant
    reductions in end-to-end training time. For instance, on 16GPUs, we can train
    the ResNet-152 network to full accuracy on ImageNet 1.8 × faster than the full-precision
    variant. '
alternative_title:
- Advances in Neural Information Processing Systems
article_processing_charge: No
arxiv: 1
author:
- first_name: Dan-Adrian
  full_name: Alistarh, Dan-Adrian
  id: 4A899BFC-F248-11E8-B48F-1D18A9856A87
  last_name: Alistarh
  orcid: 0000-0003-3650-940X
- first_name: Demjan
  full_name: Grubic, Demjan
  last_name: Grubic
- first_name: Jerry
  full_name: Li, Jerry
  last_name: Li
- first_name: Ryota
  full_name: Tomioka, Ryota
  last_name: Tomioka
- first_name: Milan
  full_name: Vojnović, Milan
  last_name: Vojnović
citation:
  ama: 'Alistarh D-A, Grubic D, Li J, Tomioka R, Vojnović M. QSGD: Communication-efficient
    SGD via gradient quantization and encoding. In: Vol 2017. Neural Information Processing
    Systems Foundation; 2017:1710-1721.'
  apa: 'Alistarh, D.-A., Grubic, D., Li, J., Tomioka, R., &#38; Vojnović, M. (2017).
    QSGD: Communication-efficient SGD via gradient quantization and encoding (Vol.
    2017, pp. 1710–1721). Presented at the NIPS: Neural Information Processing System,
    Long Beach, CA, United States: Neural Information Processing Systems Foundation.'
  chicago: 'Alistarh, Dan-Adrian, Demjan Grubic, Jerry Li, Ryota Tomioka, and Milan
    Vojnović. “QSGD: Communication-Efficient SGD via Gradient Quantization and Encoding,”
    2017:1710–21. Neural Information Processing Systems Foundation, 2017.'
  ieee: 'D.-A. Alistarh, D. Grubic, J. Li, R. Tomioka, and M. Vojnović, “QSGD: Communication-efficient
    SGD via gradient quantization and encoding,” presented at the NIPS: Neural Information
    Processing System, Long Beach, CA, United States, 2017, vol. 2017, pp. 1710–1721.'
  ista: 'Alistarh D-A, Grubic D, Li J, Tomioka R, Vojnović M. 2017. QSGD: Communication-efficient
    SGD via gradient quantization and encoding. NIPS: Neural Information Processing
    System, Advances in Neural Information Processing Systems, vol. 2017, 1710–1721.'
  mla: 'Alistarh, Dan-Adrian, et al. <i>QSGD: Communication-Efficient SGD via Gradient
    Quantization and Encoding</i>. Vol. 2017, Neural Information Processing Systems
    Foundation, 2017, pp. 1710–21.'
  short: D.-A. Alistarh, D. Grubic, J. Li, R. Tomioka, M. Vojnović, in:, Neural Information
    Processing Systems Foundation, 2017, pp. 1710–1721.
conference:
  end_date: 2017-12-09
  location: Long Beach, CA, United States
  name: 'NIPS: Neural Information Processing System'
  start_date: 2017-12-04
date_created: 2018-12-11T11:46:26Z
date_published: 2017-01-01T00:00:00Z
date_updated: 2023-10-17T11:48:03Z
day: '01'
department:
- _id: DaAl
external_id:
  arxiv:
  - '1610.02132'
intvolume: '      2017'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1610.02132
month: '01'
oa: 1
oa_version: Submitted Version
page: 1710-1721
publication_identifier:
  issn:
  - '10495258'
publication_status: published
publisher: Neural Information Processing Systems Foundation
publist_id: '7392'
quality_controlled: '1'
status: public
title: 'QSGD: Communication-efficient SGD via gradient quantization and encoding'
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 2017
year: '2017'
...
---
_id: '432'
abstract:
- lang: eng
  text: 'Recently there has been significant interest in training machine-learning
    models at low precision: by reducing precision, one can reduce computation and
    communication by one order of magnitude. We examine training at reduced precision,
    both from a theoretical and practical perspective, and ask: is it possible to
    train models at end-to-end low precision with provable guarantees? Can this lead
    to consistent order-of-magnitude speedups? We mainly focus on linear models, and
    the answer is yes for linear models. We develop a simple framework called ZipML
    based on one simple but novel strategy called double sampling. Our ZipML framework
    is able to execute training at low precision with no bias, guaranteeing convergence,
    whereas naive quanti- zation would introduce significant bias. We val- idate our
    framework across a range of applica- tions, and show that it enables an FPGA proto-
    type that is up to 6.5 × faster than an implemen- tation using full 32-bit precision.
    We further de- velop a variance-optimal stochastic quantization strategy and show
    that it can make a significant difference in a variety of settings. When applied
    to linear models together with double sampling, we save up to another 1.7 × in
    data movement compared with uniform quantization. When training deep networks
    with quantized models, we achieve higher accuracy than the state-of-the- art XNOR-Net. '
alternative_title:
- PMLR Press
article_processing_charge: No
author:
- first_name: Hantian
  full_name: Zhang, Hantian
  last_name: Zhang
- first_name: Jerry
  full_name: Li, Jerry
  last_name: Li
- first_name: Kaan
  full_name: Kara, Kaan
  last_name: Kara
- first_name: Dan-Adrian
  full_name: Alistarh, Dan-Adrian
  id: 4A899BFC-F248-11E8-B48F-1D18A9856A87
  last_name: Alistarh
  orcid: 0000-0003-3650-940X
- first_name: Ji
  full_name: Liu, Ji
  last_name: Liu
- first_name: Ce
  full_name: Zhang, Ce
  last_name: Zhang
citation:
  ama: 'Zhang H, Li J, Kara K, Alistarh D-A, Liu J, Zhang C. ZipML: Training linear
    models with end-to-end low precision, and a little bit of deep learning. In: <i>Proceedings
    of Machine Learning Research</i>. Vol 70. ML Research Press; 2017:4035-4043.'
  apa: 'Zhang, H., Li, J., Kara, K., Alistarh, D.-A., Liu, J., &#38; Zhang, C. (2017).
    ZipML: Training linear models with end-to-end low precision, and a little bit
    of deep learning. In <i>Proceedings of Machine Learning Research</i> (Vol. 70,
    pp. 4035–4043). Sydney, Australia: ML Research Press.'
  chicago: 'Zhang, Hantian, Jerry Li, Kaan Kara, Dan-Adrian Alistarh, Ji Liu, and
    Ce Zhang. “ZipML: Training Linear Models with End-to-End Low Precision, and a
    Little Bit of Deep Learning.” In <i>Proceedings of Machine Learning Research</i>,
    70:4035–43. ML Research Press, 2017.'
  ieee: 'H. Zhang, J. Li, K. Kara, D.-A. Alistarh, J. Liu, and C. Zhang, “ZipML: Training
    linear models with end-to-end low precision, and a little bit of deep learning,”
    in <i>Proceedings of Machine Learning Research</i>, Sydney, Australia, 2017, vol.
    70, pp. 4035–4043.'
  ista: 'Zhang H, Li J, Kara K, Alistarh D-A, Liu J, Zhang C. 2017. ZipML: Training
    linear models with end-to-end low precision, and a little bit of deep learning.
    Proceedings of Machine Learning Research. ICML: International  Conference  on 
    Machine Learning, PMLR Press, vol. 70, 4035–4043.'
  mla: 'Zhang, Hantian, et al. “ZipML: Training Linear Models with End-to-End Low
    Precision, and a Little Bit of Deep Learning.” <i>Proceedings of Machine Learning
    Research</i>, vol. 70, ML Research Press, 2017, pp. 4035–43.'
  short: H. Zhang, J. Li, K. Kara, D.-A. Alistarh, J. Liu, C. Zhang, in:, Proceedings
    of Machine Learning Research, ML Research Press, 2017, pp. 4035–4043.
conference:
  end_date: 2017-08-11
  location: Sydney, Australia
  name: 'ICML: International  Conference  on  Machine Learning'
  start_date: 2017-08-06
date_created: 2018-12-11T11:46:26Z
date_published: 2017-01-01T00:00:00Z
date_updated: 2023-10-17T12:31:15Z
day: '01'
ddc:
- '000'
department:
- _id: DaAl
file:
- access_level: open_access
  checksum: 86156ba7f4318e47cef3eb9092593c10
  content_type: application/pdf
  creator: dernst
  date_created: 2019-01-22T08:23:58Z
  date_updated: 2020-07-14T12:46:26Z
  file_id: '5869'
  file_name: 2017_ICML_Zhang.pdf
  file_size: 849345
  relation: main_file
file_date_updated: 2020-07-14T12:46:26Z
has_accepted_license: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Submitted Version
page: 4035 - 4043
publication: Proceedings of Machine Learning Research
publication_identifier:
  isbn:
  - 978-151085514-4
publication_status: published
publisher: ML Research Press
publist_id: '7391'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'ZipML: Training linear models with end-to-end low precision, and a little
  bit of deep learning'
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: ' 70'
year: '2017'
...
---
_id: '443'
abstract:
- lang: eng
  text: Pancreatic cancer has a five-year survival rate of ~8%, with characteristic
    molecular heterogeneity and restricted treatment options. Targeting metabolism
    has emerged as a potentially effective therapeutic strategy for cancers such as
    pancreatic cancer, which are driven by genetic alterations that are not tractable
    drug targets. Although somatic mitochondrial genome (mtDNA) mutations have been
    observed in various tumors types, understanding of metabolic genotype-phenotype
    relationships is limited.
author:
- first_name: Rae
  full_name: Hardie, Rae
  last_name: Hardie
- first_name: Ellen
  full_name: Van Dam, Ellen
  last_name: Van Dam
- first_name: Mark
  full_name: Cowley, Mark
  last_name: Cowley
- first_name: Ting
  full_name: Han, Ting
  last_name: Han
- first_name: Seher
  full_name: Balaban, Seher
  last_name: Balaban
- first_name: Marina
  full_name: Pajic, Marina
  last_name: Pajic
- first_name: Mark
  full_name: Pinese, Mark
  last_name: Pinese
- first_name: Mary
  full_name: Iconomou, Mary
  last_name: Iconomou
- first_name: Robert
  full_name: Shearer, Robert
  last_name: Shearer
- first_name: Jessie
  full_name: Mckenna, Jessie
  last_name: Mckenna
- first_name: David
  full_name: Miller, David
  last_name: Miller
- first_name: Nicola
  full_name: Waddell, Nicola
  last_name: Waddell
- first_name: John
  full_name: Pearson, John
  last_name: Pearson
- first_name: Sean
  full_name: Grimmond, Sean
  last_name: Grimmond
- first_name: Leonid A
  full_name: Sazanov, Leonid A
  id: 338D39FE-F248-11E8-B48F-1D18A9856A87
  last_name: Sazanov
  orcid: 0000-0002-0977-7989
- first_name: Andrew
  full_name: Biankin, Andrew
  last_name: Biankin
- first_name: Silas
  full_name: Villas Boas, Silas
  last_name: Villas Boas
- first_name: Andrew
  full_name: Hoy, Andrew
  last_name: Hoy
- first_name: Nigel
  full_name: Turner, Nigel
  last_name: Turner
- first_name: Darren
  full_name: Saunders, Darren
  last_name: Saunders
citation:
  ama: Hardie R, Van Dam E, Cowley M, et al. Mitochondrial mutations and metabolic
    adaptation in pancreatic cancer. <i>Cancer &#38; Metabolism</i>. 2017;5(2). doi:<a
    href="https://doi.org/10.1186/s40170-017-0164-1">10.1186/s40170-017-0164-1</a>
  apa: Hardie, R., Van Dam, E., Cowley, M., Han, T., Balaban, S., Pajic, M., … Saunders,
    D. (2017). Mitochondrial mutations and metabolic adaptation in pancreatic cancer.
    <i>Cancer &#38; Metabolism</i>. BioMed Central. <a href="https://doi.org/10.1186/s40170-017-0164-1">https://doi.org/10.1186/s40170-017-0164-1</a>
  chicago: Hardie, Rae, Ellen Van Dam, Mark Cowley, Ting Han, Seher Balaban, Marina
    Pajic, Mark Pinese, et al. “Mitochondrial Mutations and Metabolic Adaptation in
    Pancreatic Cancer.” <i>Cancer &#38; Metabolism</i>. BioMed Central, 2017. <a href="https://doi.org/10.1186/s40170-017-0164-1">https://doi.org/10.1186/s40170-017-0164-1</a>.
  ieee: R. Hardie <i>et al.</i>, “Mitochondrial mutations and metabolic adaptation
    in pancreatic cancer,” <i>Cancer &#38; Metabolism</i>, vol. 5, no. 2. BioMed Central,
    2017.
  ista: Hardie R, Van Dam E, Cowley M, Han T, Balaban S, Pajic M, Pinese M, Iconomou
    M, Shearer R, Mckenna J, Miller D, Waddell N, Pearson J, Grimmond S, Sazanov LA,
    Biankin A, Villas Boas S, Hoy A, Turner N, Saunders D. 2017. Mitochondrial mutations
    and metabolic adaptation in pancreatic cancer. Cancer &#38; Metabolism. 5(2).
  mla: Hardie, Rae, et al. “Mitochondrial Mutations and Metabolic Adaptation in Pancreatic
    Cancer.” <i>Cancer &#38; Metabolism</i>, vol. 5, no. 2, BioMed Central, 2017,
    doi:<a href="https://doi.org/10.1186/s40170-017-0164-1">10.1186/s40170-017-0164-1</a>.
  short: R. Hardie, E. Van Dam, M. Cowley, T. Han, S. Balaban, M. Pajic, M. Pinese,
    M. Iconomou, R. Shearer, J. Mckenna, D. Miller, N. Waddell, J. Pearson, S. Grimmond,
    L.A. Sazanov, A. Biankin, S. Villas Boas, A. Hoy, N. Turner, D. Saunders, Cancer
    &#38; Metabolism 5 (2017).
date_created: 2018-12-11T11:46:30Z
date_published: 2017-01-30T00:00:00Z
date_updated: 2021-01-12T07:56:55Z
day: '30'
ddc:
- '570'
doi: 10.1186/s40170-017-0164-1
extern: '1'
file:
- access_level: open_access
  checksum: 337a65786875f64a1fe9fc0ac24767dc
  content_type: application/pdf
  creator: dernst
  date_created: 2019-01-22T08:17:56Z
  date_updated: 2020-07-14T12:46:29Z
  file_id: '5868'
  file_name: 2017_Cancer_Hardie.pdf
  file_size: 1609174
  relation: main_file
file_date_updated: 2020-07-14T12:46:29Z
has_accepted_license: '1'
intvolume: '         5'
issue: '2'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
publication: Cancer & Metabolism
publication_status: published
publisher: BioMed Central
publist_id: '7380'
quality_controlled: '1'
status: public
title: Mitochondrial mutations and metabolic adaptation in pancreatic cancer
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 5
year: '2017'
...
---
_id: '444'
abstract:
- lang: eng
  text: Complex I (NADH:ubiquinone oxidoreductase) plays a central role in cellular
    energy generation, contributing to the proton motive force used to produce ATP.
    It couples the transfer of two electrons between NADH and quinone to translocation
    of four protons across the membrane. It is the largest protein assembly of bacterial
    and mitochondrial respiratory chains, composed, in mammals, of up to 45 subunits
    with a total molecular weight of ∼1 MDa. Bacterial enzyme is about half the size,
    providing the important “minimal” model of complex I. The l-shaped complex consists
    of a hydrophilic arm, where electron transfer occurs, and a membrane arm, where
    proton translocation takes place. Previously, we have solved the crystal structures
    of the hydrophilic domain of complex I from Thermus thermophilus and of the membrane
    domain from Escherichia coli, followed by the atomic structure of intact, entire
    complex I from T. thermophilus. Recently, we have solved by cryo-EM a first complete
    atomic structure of mammalian (ovine) mitochondrial complex I. Core subunits are
    well conserved from the bacterial version, whilst supernumerary subunits form
    an interlinked, stabilizing shell around the core. Subunits containing additional
    cofactors, including Zn ion, NADPH and phosphopantetheine, probably have regulatory
    roles. Dysfunction of mitochondrial complex I is implicated in many human neurodegenerative
    diseases. The structure of mammalian enzyme provides many insights into complex
    I mechanism, assembly, maturation and dysfunction, allowing detailed molecular
    analysis of disease-causing mutations.
author:
- first_name: Leonid A
  full_name: Sazanov, Leonid A
  id: 338D39FE-F248-11E8-B48F-1D18A9856A87
  last_name: Sazanov
  orcid: 0000-0002-0977-7989
citation:
  ama: 'Sazanov LA. Structure of respiratory complex I: “Minimal” bacterial and “de
    luxe” mammalian versions. In: Wikström M, ed. <i>Mechanisms of Primary Energy
    Transduction in Biology </i>. Mechanisms of Primary Energy Transduction in Biology
    . Royal Society of Chemistry; 2017:25-59. doi:<a href="https://doi.org/10.1039/9781788010405-00025">10.1039/9781788010405-00025</a>'
  apa: 'Sazanov, L. A. (2017). Structure of respiratory complex I: “Minimal” bacterial
    and “de luxe” mammalian versions. In M. Wikström (Ed.), <i>Mechanisms of primary
    energy transduction in biology </i> (pp. 25–59). Royal Society of Chemistry. <a
    href="https://doi.org/10.1039/9781788010405-00025">https://doi.org/10.1039/9781788010405-00025</a>'
  chicago: 'Sazanov, Leonid A. “Structure of Respiratory Complex I: ‘Minimal’ Bacterial
    and ‘de Luxe’ Mammalian Versions.” In <i>Mechanisms of Primary Energy Transduction
    in Biology </i>, edited by Mårten Wikström, 25–59. Mechanisms of Primary Energy
    Transduction in Biology . Royal Society of Chemistry, 2017. <a href="https://doi.org/10.1039/9781788010405-00025">https://doi.org/10.1039/9781788010405-00025</a>.'
  ieee: 'L. A. Sazanov, “Structure of respiratory complex I: ‘Minimal’ bacterial and
    ‘de luxe’ mammalian versions,” in <i>Mechanisms of primary energy transduction
    in biology </i>, M. Wikström, Ed. Royal Society of Chemistry, 2017, pp. 25–59.'
  ista: 'Sazanov LA. 2017.Structure of respiratory complex I: “Minimal” bacterial
    and “de luxe” mammalian versions. In: Mechanisms of primary energy transduction
    in biology . , 25–59.'
  mla: 'Sazanov, Leonid A. “Structure of Respiratory Complex I: ‘Minimal’ Bacterial
    and ‘de Luxe’ Mammalian Versions.” <i>Mechanisms of Primary Energy Transduction
    in Biology </i>, edited by Mårten Wikström, Royal Society of Chemistry, 2017,
    pp. 25–59, doi:<a href="https://doi.org/10.1039/9781788010405-00025">10.1039/9781788010405-00025</a>.'
  short: L.A. Sazanov, in:, M. Wikström (Ed.), Mechanisms of Primary Energy Transduction
    in Biology , Royal Society of Chemistry, 2017, pp. 25–59.
date_created: 2018-12-11T11:46:30Z
date_published: 2017-11-29T00:00:00Z
date_updated: 2021-01-12T07:56:59Z
day: '29'
department:
- _id: LeSa
doi: 10.1039/9781788010405-00025
editor:
- first_name: Mårten
  full_name: Wikström, Mårten
  last_name: Wikström
language:
- iso: eng
month: '11'
oa_version: None
page: 25 - 59
publication: 'Mechanisms of primary energy transduction in biology '
publication_identifier:
  isbn:
  - 978-1-78262-865-1
publication_status: published
publisher: Royal Society of Chemistry
publist_id: '7379'
quality_controlled: '1'
series_title: 'Mechanisms of Primary Energy Transduction in Biology '
status: public
title: 'Structure of respiratory complex I: “Minimal” bacterial and “de luxe” mammalian
  versions'
type: book_chapter
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2017'
...
---
_id: '445'
abstract:
- lang: eng
  text: The Loschmidt echo, defined as the overlap between quantum wave function evolved
    with different Hamiltonians, quantifies the sensitivity of quantum dynamics to
    perturbations and is often used as a probe of quantum chaos. In this work we consider
    the behavior of the Loschmidt echo in the many-body localized phase, which is
    characterized by emergent local integrals of motion and provides a generic example
    of nonergodic dynamics. We demonstrate that the fluctuations of the Loschmidt
    echo decay as a power law in time in the many-body localized phase, in contrast
    to the exponential decay in few-body ergodic systems. We consider the spin-echo
    generalization of the Loschmidt echo and argue that the corresponding correlation
    function saturates to a finite value in localized systems. Slow, power-law decay
    of fluctuations of such spin-echo-type overlap is related to the operator spreading
    and is present only in the many-body localized phase, but not in a noninteracting
    Anderson insulator. While most of the previously considered probes of dephasing
    dynamics could be understood by approximating physical spin operators with local
    integrals of motion, the Loschmidt echo and its generalizations crucially depend
    on the full expansion of the physical operators via local integrals of motion
    operators, as well as operators which flip local integrals of motion. Hence these
    probes allow one to get insights into the relation between physical operators
    and local integrals of motion and access the operator spreading in the many-body
    localized phase.
acknowledgement: |-
  This research was supported in part by the National
  Science Foundation under Grant No. NSF PHY11-25915.
  M.S. was supported by Gordon and Betty Moore Foundation’s
  EPiQS Initiative through Grant No. GBMF4307. D.A. also
  acknowledges support by Swiss National Science Foundation.
author:
- first_name: Maksym
  full_name: Maksym Serbyn
  id: 47809E7E-F248-11E8-B48F-1D18A9856A87
  last_name: Serbyn
  orcid: 0000-0002-2399-5827
- first_name: Dimitry
  full_name: Abanin, Dimitry A
  last_name: Abanin
citation:
  ama: Serbyn M, Abanin D. Loschmidt echo in many body localized phases. <i>Physical
    Review B - Condensed Matter and Materials Physics</i>. 2017;96(1). doi:<a href="https://doi.org/10.1103/PhysRevB.96.014202">10.1103/PhysRevB.96.014202</a>
  apa: Serbyn, M., &#38; Abanin, D. (2017). Loschmidt echo in many body localized
    phases. <i>Physical Review B - Condensed Matter and Materials Physics</i>. American
    Physical Society. <a href="https://doi.org/10.1103/PhysRevB.96.014202">https://doi.org/10.1103/PhysRevB.96.014202</a>
  chicago: Serbyn, Maksym, and Dimitry Abanin. “Loschmidt Echo in Many Body Localized
    Phases.” <i>Physical Review B - Condensed Matter and Materials Physics</i>. American
    Physical Society, 2017. <a href="https://doi.org/10.1103/PhysRevB.96.014202">https://doi.org/10.1103/PhysRevB.96.014202</a>.
  ieee: M. Serbyn and D. Abanin, “Loschmidt echo in many body localized phases,” <i>Physical
    Review B - Condensed Matter and Materials Physics</i>, vol. 96, no. 1. American
    Physical Society, 2017.
  ista: Serbyn M, Abanin D. 2017. Loschmidt echo in many body localized phases. Physical
    Review B - Condensed Matter and Materials Physics. 96(1).
  mla: Serbyn, Maksym, and Dimitry Abanin. “Loschmidt Echo in Many Body Localized
    Phases.” <i>Physical Review B - Condensed Matter and Materials Physics</i>, vol.
    96, no. 1, American Physical Society, 2017, doi:<a href="https://doi.org/10.1103/PhysRevB.96.014202">10.1103/PhysRevB.96.014202</a>.
  short: M. Serbyn, D. Abanin, Physical Review B - Condensed Matter and Materials
    Physics 96 (2017).
date_created: 2018-12-11T11:46:31Z
date_published: 2017-07-12T00:00:00Z
date_updated: 2021-01-12T07:57:03Z
day: '12'
doi: 10.1103/PhysRevB.96.014202
extern: 1
intvolume: '        96'
issue: '1'
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1701.07772
month: '07'
oa: 1
publication: Physical Review B - Condensed Matter and Materials Physics
publication_status: published
publisher: American Physical Society
publist_id: '7378'
quality_controlled: 0
status: public
title: Loschmidt echo in many body localized phases
type: journal_article
volume: 96
year: '2017'
...
---
_id: '447'
abstract:
- lang: eng
  text: We consider last passage percolation (LPP) models with exponentially distributed
    random variables, which are linked to the totally asymmetric simple exclusion
    process (TASEP). The competition interface for LPP was introduced and studied
    in Ferrari and Pimentel (2005a) for cases where the corresponding exclusion process
    had a rarefaction fan. Here we consider situations with a shock and determine
    the law of the fluctuations of the competition interface around its deter- ministic
    law of large number position. We also study the multipoint distribution of the
    LPP around the shock, extending our one-point result of Ferrari and Nejjar (2015).
article_processing_charge: No
article_type: original
author:
- first_name: Patrik
  full_name: Ferrari, Patrik
  last_name: Ferrari
- first_name: Peter
  full_name: Nejjar, Peter
  id: 4BF426E2-F248-11E8-B48F-1D18A9856A87
  last_name: Nejjar
citation:
  ama: Ferrari P, Nejjar P. Fluctuations of the competition interface in presence
    of shocks. <i>Revista Latino-Americana de Probabilidade e Estatística</i>. 2017;9:299-325.
    doi:<a href="https://doi.org/10.30757/ALEA.v14-17">10.30757/ALEA.v14-17</a>
  apa: Ferrari, P., &#38; Nejjar, P. (2017). Fluctuations of the competition interface
    in presence of shocks. <i>Revista Latino-Americana de Probabilidade e Estatística</i>.
    Instituto Nacional de Matematica Pura e Aplicada. <a href="https://doi.org/10.30757/ALEA.v14-17">https://doi.org/10.30757/ALEA.v14-17</a>
  chicago: Ferrari, Patrik, and Peter Nejjar. “Fluctuations of the Competition Interface
    in Presence of Shocks.” <i>Revista Latino-Americana de Probabilidade e Estatística</i>.
    Instituto Nacional de Matematica Pura e Aplicada, 2017. <a href="https://doi.org/10.30757/ALEA.v14-17">https://doi.org/10.30757/ALEA.v14-17</a>.
  ieee: P. Ferrari and P. Nejjar, “Fluctuations of the competition interface in presence
    of shocks,” <i>Revista Latino-Americana de Probabilidade e Estatística</i>, vol.
    9. Instituto Nacional de Matematica Pura e Aplicada, pp. 299–325, 2017.
  ista: Ferrari P, Nejjar P. 2017. Fluctuations of the competition interface in presence
    of shocks. Revista Latino-Americana de Probabilidade e Estatística. 9, 299–325.
  mla: Ferrari, Patrik, and Peter Nejjar. “Fluctuations of the Competition Interface
    in Presence of Shocks.” <i>Revista Latino-Americana de Probabilidade e Estatística</i>,
    vol. 9, Instituto Nacional de Matematica Pura e Aplicada, 2017, pp. 299–325, doi:<a
    href="https://doi.org/10.30757/ALEA.v14-17">10.30757/ALEA.v14-17</a>.
  short: P. Ferrari, P. Nejjar, Revista Latino-Americana de Probabilidade e Estatística
    9 (2017) 299–325.
date_created: 2018-12-11T11:46:31Z
date_published: 2017-03-23T00:00:00Z
date_updated: 2023-10-10T13:10:32Z
day: '23'
department:
- _id: LaEr
- _id: JaMa
doi: 10.30757/ALEA.v14-17
ec_funded: 1
intvolume: '         9'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://alea.impa.br/articles/v14/14-17.pdf
month: '03'
oa: 1
oa_version: Submitted Version
page: 299 - 325
project:
- _id: 258DCDE6-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '338804'
  name: Random matrices, universality and disordered quantum systems
publication: Revista Latino-Americana de Probabilidade e Estatística
publication_status: published
publisher: Instituto Nacional de Matematica Pura e Aplicada
publist_id: '7376'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Fluctuations of the competition interface in presence of shocks
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 9
year: '2017'
...
---
_id: '452'
abstract:
- lang: eng
  text: 'Spinning tops and yo-yos have long fascinated cultures around the world with
    their unexpected, graceful motions that seemingly elude gravity. Yet, due to the
    exceeding difficulty of creating stably spinning objects of asymmetric shape in
    a manual trial-and-error process, there has been little departure from rotationally
    symmetric designs. With modern 3D printing technologies, however, we can manufacture
    shapes of almost unbounded complexity at the press of a button, shifting this
    design complexity toward computation. In this article, we describe an algorithm
    to generate designs for spinning objects by optimizing their mass distribution:
    as input, the user provides a solid 3D model and a desired axis of rotation. Our
    approach then modifies the interior mass distribution such that the principal
    directions of the moment of inertia align with the target rotation frame. To create
    voids inside the model, we represent its volume with an adaptive multiresolution
    voxelization and optimize the discrete voxel fill values using a continuous, nonlinear
    formulation. We further optimize for rotational stability by maximizing the dominant
    principal moment. Our method is well-suited for a variety of 3D printed models,
    ranging from characters to abstract shapes. We demonstrate tops and yo-yos that
    spin surprisingly stably despite their asymmetric appearance.'
acknowledgement: "This project was supported in part by the ERC Starting Grant iModel
  (StG-2012-306877). Emily Whiting was supported by the ETH Zurich/Marie Curie COFUND
  Postdoctoral Fellowship. \r\nFirst and foremost, we would like to thank our editor
  Steve Marschner for his invaluable feedback. We were fortunate to get further help
  from Maurizio Nitti for model design, Romain Prévost for Make-It-Stand comparisons,
  Alexander Sorkine-Hornung, Kaan Yücer, and Changil Kim for video and photo assistance,
  Ronnie Gänsli for metal casting, Alec Jacobson for the posed Elephant and Armadillo
  models, and Romain Prévost and Amit Bermano for print preparation. Model sources
  include: Woven Ring: generated by “Sculpture Generator 1” by Carlo H. Séquin, UC
  Berkeley; Elephant: De Espona model library, courtesy of Robert Sumner; T-Rex: TurboSquid;
  Armadillo: Stanford Computer Graphics Laboratory; and Utah Teapot: Martin Newell,
  University of Utah. "
article_processing_charge: No
author:
- first_name: Moritz
  full_name: Bächer, Moritz
  last_name: Bächer
- first_name: Bernd
  full_name: Bickel, Bernd
  id: 49876194-F248-11E8-B48F-1D18A9856A87
  last_name: Bickel
  orcid: 0000-0001-6511-9385
- first_name: Emily
  full_name: Whiting, Emily
  last_name: Whiting
- first_name: Olga
  full_name: Sorkine Hornung, Olga
  last_name: Sorkine Hornung
citation:
  ama: 'Bächer M, Bickel B, Whiting E, Sorkine Hornung O. Spin it: Optimizing moment
    of inertia for spinnable objects. <i>Communications of the ACM</i>. 2017;60(8):92-99.
    doi:<a href="https://doi.org/10.1145/3068766">10.1145/3068766</a>'
  apa: 'Bächer, M., Bickel, B., Whiting, E., &#38; Sorkine Hornung, O. (2017). Spin
    it: Optimizing moment of inertia for spinnable objects. <i>Communications of the
    ACM</i>. ACM. <a href="https://doi.org/10.1145/3068766">https://doi.org/10.1145/3068766</a>'
  chicago: 'Bächer, Moritz, Bernd Bickel, Emily Whiting, and Olga Sorkine Hornung.
    “Spin It: Optimizing Moment of Inertia for Spinnable Objects.” <i>Communications
    of the ACM</i>. ACM, 2017. <a href="https://doi.org/10.1145/3068766">https://doi.org/10.1145/3068766</a>.'
  ieee: 'M. Bächer, B. Bickel, E. Whiting, and O. Sorkine Hornung, “Spin it: Optimizing
    moment of inertia for spinnable objects,” <i>Communications of the ACM</i>, vol.
    60, no. 8. ACM, pp. 92–99, 2017.'
  ista: 'Bächer M, Bickel B, Whiting E, Sorkine Hornung O. 2017. Spin it: Optimizing
    moment of inertia for spinnable objects. Communications of the ACM. 60(8), 92–99.'
  mla: 'Bächer, Moritz, et al. “Spin It: Optimizing Moment of Inertia for Spinnable
    Objects.” <i>Communications of the ACM</i>, vol. 60, no. 8, ACM, 2017, pp. 92–99,
    doi:<a href="https://doi.org/10.1145/3068766">10.1145/3068766</a>.'
  short: M. Bächer, B. Bickel, E. Whiting, O. Sorkine Hornung, Communications of the
    ACM 60 (2017) 92–99.
date_created: 2018-12-11T11:46:33Z
date_published: 2017-08-01T00:00:00Z
date_updated: 2022-03-18T12:55:28Z
day: '01'
doi: 10.1145/3068766
extern: '1'
intvolume: '        60'
issue: '8'
language:
- iso: eng
month: '08'
oa_version: None
page: 92 - 99
publication: Communications of the ACM
publication_status: published
publisher: ACM
publist_id: '7370'
scopus_import: '1'
status: public
title: 'Spin it: Optimizing moment of inertia for spinnable objects'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 60
year: '2017'
...
---
_id: '453'
abstract:
- lang: eng
  text: Most kinesin motors move in only one direction along microtubules. Members
    of the kinesin-5 subfamily were initially described as unidirectional plus-end-directed
    motors and shown to produce piconewton forces. However, some fungal kinesin-5
    motors are bidirectional. The force production of a bidirectional kinesin-5 has
    not yet been measured. Therefore, it remains unknown whether the mechanism of
    the unconventional minus-end-directed motility differs fundamentally from that
    of plus-end-directed stepping. Using force spectroscopy, we have measured here
    the forces that ensembles of purified budding yeast kinesin-5 Cin8 produce in
    microtubule gliding assays in both plus- and minus-end direction. Correlation
    analysis of pause forces demonstrated that individual Cin8 molecules produce additive
    forces in both directions of movement. In ensembles, Cin8 motors were able to
    produce single-motor forces up to a magnitude of ∼1.5 pN. Hence, these properties
    appear to be conserved within the kinesin-5 subfamily. Force production was largely
    independent of the directionality of movement, indicating similarities between
    the motility mechanisms for both directions. These results provide constraints
    for the development of models for the bidirectional motility mechanism of fission
    yeast kinesin-5 and provide insight into the function of this mitotic motor.
acknowledgement: 'The plasmid for full-length kinesin-1 was a gift from G. Holzwarth
  and J. Macosko with permission from J. Howard. We thank I. Lueke and N. I. Cade
  for technical assistance. G.P. thanks the Francis Crick Institute, and in particular
  the Surrey and Salbreux groups, for their hospitality during his sabbatical stay,
  as well as Imperial College London for making it possible. This work was supported
  by the Francis Crick Institute, which receives its core funding from Cancer Research
  UK (FC001163), the United Kingdom Medical Research Council (FC001163), and the Wellcome
  Trust (FC001163), and by Imperial College London. J.R. was also supported by a Sir
  Henry Wellcome Postdoctoral Fellowship (100145/Z/12/Z) and T.S. by the European
  Research Council (Advanced Grant, project 323042). '
article_processing_charge: No
article_type: original
author:
- first_name: Todd
  full_name: Fallesen, Todd
  last_name: Fallesen
- first_name: Johanna
  full_name: Roostalu, Johanna
  last_name: Roostalu
- first_name: Christian F
  full_name: Düllberg, Christian F
  id: 459064DC-F248-11E8-B48F-1D18A9856A87
  last_name: Düllberg
  orcid: 0000-0001-6335-9748
- first_name: Gunnar
  full_name: Pruessner, Gunnar
  last_name: Pruessner
- first_name: Thomas
  full_name: Surrey, Thomas
  last_name: Surrey
citation:
  ama: Fallesen T, Roostalu J, Düllberg CF, Pruessner G, Surrey T. Ensembles of bidirectional
    kinesin Cin8 produce additive forces in both directions of movement. <i>Biophysical
    Journal</i>. 2017;113(9):2055-2067. doi:<a href="https://doi.org/10.1016/j.bpj.2017.09.006">10.1016/j.bpj.2017.09.006</a>
  apa: Fallesen, T., Roostalu, J., Düllberg, C. F., Pruessner, G., &#38; Surrey, T.
    (2017). Ensembles of bidirectional kinesin Cin8 produce additive forces in both
    directions of movement. <i>Biophysical Journal</i>. Biophysical Society. <a href="https://doi.org/10.1016/j.bpj.2017.09.006">https://doi.org/10.1016/j.bpj.2017.09.006</a>
  chicago: Fallesen, Todd, Johanna Roostalu, Christian F Düllberg, Gunnar Pruessner,
    and Thomas Surrey. “Ensembles of Bidirectional Kinesin Cin8 Produce Additive Forces
    in Both Directions of Movement.” <i>Biophysical Journal</i>. Biophysical Society,
    2017. <a href="https://doi.org/10.1016/j.bpj.2017.09.006">https://doi.org/10.1016/j.bpj.2017.09.006</a>.
  ieee: T. Fallesen, J. Roostalu, C. F. Düllberg, G. Pruessner, and T. Surrey, “Ensembles
    of bidirectional kinesin Cin8 produce additive forces in both directions of movement,”
    <i>Biophysical Journal</i>, vol. 113, no. 9. Biophysical Society, pp. 2055–2067,
    2017.
  ista: Fallesen T, Roostalu J, Düllberg CF, Pruessner G, Surrey T. 2017. Ensembles
    of bidirectional kinesin Cin8 produce additive forces in both directions of movement.
    Biophysical Journal. 113(9), 2055–2067.
  mla: Fallesen, Todd, et al. “Ensembles of Bidirectional Kinesin Cin8 Produce Additive
    Forces in Both Directions of Movement.” <i>Biophysical Journal</i>, vol. 113,
    no. 9, Biophysical Society, 2017, pp. 2055–67, doi:<a href="https://doi.org/10.1016/j.bpj.2017.09.006">10.1016/j.bpj.2017.09.006</a>.
  short: T. Fallesen, J. Roostalu, C.F. Düllberg, G. Pruessner, T. Surrey, Biophysical
    Journal 113 (2017) 2055–2067.
date_created: 2018-12-11T11:46:33Z
date_published: 2017-11-07T00:00:00Z
date_updated: 2021-01-12T07:59:28Z
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doi: 10.1016/j.bpj.2017.09.006
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publication: Biophysical Journal
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title: Ensembles of bidirectional kinesin Cin8 produce additive forces in both directions
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