---
_id: '12633'
abstract:
- lang: eng
text: We use two hydrological models of varying complexity to study the Juncal River
Basin in the Central Andes of Chile with the aim to understand the degree of conceptualization
and the spatial structure that are needed to model present and future streamflows.
We use a conceptual semi-distributed model based on elevation bands [Water Evaluation
and Planning (WEAP)], frequently used for water management, and a physically oriented,
fully distributed model [Topographic Kinematic Wave Approximation and Integration
ETH Zurich (TOPKAPI-ETH)] developed for research purposes mainly. We evaluate
the ability of the two models to reproduce the key hydrological processes in the
basin with emphasis on snow accumulation and melt, streamflow and the relationships
between internal processes. Both models are capable of reproducing observed runoff
and the evolution of Moderate-resolution Imaging Spectroradiometer snow cover
adequately. In spite of WEAP's simple and conceptual approach for modelling snowmelt
and its lack of glacier representation and snow gravitational redistribution as
well as a proper routing algorithm, this model can reproduce historical data with
a similar goodness of fit as the more complex TOPKAPI-ETH. We show that the performance
of both models can be improved by using measured precipitation gradients of higher
temporal resolution. In contrast to the good performance of the conceptual model
for the present climate, however, we demonstrate that the simplifications in WEAP
lead to error compensation, which results in different predictions in simulated
melt and runoff for a potentially warmer future climate. TOPKAPI-ETH, using a
more physical representation of processes, depends less on calibration and thus
is less subject to a compensation of errors through different model components.
Our results show that data obtained locally in ad hoc short-term field campaigns
are needed to complement data extrapolated from long-term records for simulating
changes in the water cycle of high-elevation catchments but that these data can
only be efficiently used by a model applying a spatially distributed physical
representation of hydrological processes.
article_processing_charge: No
article_type: original
author:
- first_name: S.
full_name: Ragettli, S.
last_name: Ragettli
- first_name: G.
full_name: Cortés, G.
last_name: Cortés
- first_name: J.
full_name: McPhee, J.
last_name: McPhee
- first_name: Francesca
full_name: Pellicciotti, Francesca
id: b28f055a-81ea-11ed-b70c-a9fe7f7b0e70
last_name: Pellicciotti
citation:
ama: Ragettli S, Cortés G, McPhee J, Pellicciotti F. An evaluation of approaches
for modelling hydrological processes in high-elevation, glacierized Andean watersheds.
Hydrological Processes. 2013;28(23):5674-5695. doi:10.1002/hyp.10055
apa: Ragettli, S., Cortés, G., McPhee, J., & Pellicciotti, F. (2013). An evaluation
of approaches for modelling hydrological processes in high-elevation, glacierized
Andean watersheds. Hydrological Processes. Wiley. https://doi.org/10.1002/hyp.10055
chicago: Ragettli, S., G. Cortés, J. McPhee, and Francesca Pellicciotti. “An Evaluation
of Approaches for Modelling Hydrological Processes in High-Elevation, Glacierized
Andean Watersheds.” Hydrological Processes. Wiley, 2013. https://doi.org/10.1002/hyp.10055.
ieee: S. Ragettli, G. Cortés, J. McPhee, and F. Pellicciotti, “An evaluation of
approaches for modelling hydrological processes in high-elevation, glacierized
Andean watersheds,” Hydrological Processes, vol. 28, no. 23. Wiley, pp.
5674–5695, 2013.
ista: Ragettli S, Cortés G, McPhee J, Pellicciotti F. 2013. An evaluation of approaches
for modelling hydrological processes in high-elevation, glacierized Andean watersheds.
Hydrological Processes. 28(23), 5674–5695.
mla: Ragettli, S., et al. “An Evaluation of Approaches for Modelling Hydrological
Processes in High-Elevation, Glacierized Andean Watersheds.” Hydrological Processes,
vol. 28, no. 23, Wiley, 2013, pp. 5674–95, doi:10.1002/hyp.10055.
short: S. Ragettli, G. Cortés, J. McPhee, F. Pellicciotti, Hydrological Processes
28 (2013) 5674–5695.
date_created: 2023-02-20T08:16:39Z
date_published: 2013-09-06T00:00:00Z
date_updated: 2023-02-24T08:48:40Z
day: '06'
doi: 10.1002/hyp.10055
extern: '1'
intvolume: ' 28'
issue: '23'
keyword:
- Water Science and Technology
language:
- iso: eng
month: '09'
oa_version: None
page: 5674-5695
publication: Hydrological Processes
publication_identifier:
issn:
- 0885-6087
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: An evaluation of approaches for modelling hydrological processes in high-elevation,
glacierized Andean watersheds
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 28
year: '2013'
...
---
_id: '12638'
abstract:
- lang: eng
text: Central Asian water resources largely depend on melt water generated in the
Pamir and Tien Shan mountain ranges. To estimate future water availability in
this region, it is necessary to use climate projections to estimate the future
glacier extent and volume. In this study, we evaluate the impact of uncertainty
in climate change projections on the future glacier extent in the Amu and Syr
Darya river basins. To this end we use the latest climate change projections generated
for the upcoming IPCC report (CMIP5) and, for comparison, projections used in
the fourth IPCC assessment (CMIP3). With these projections we force a regionalized
glacier mass balance model, and estimate changes in the basins' glacier extent
as a function of the glacier size distribution in the basins and projected temperature
and precipitation. This glacier mass balance model is specifically developed for
implementation in large scale hydrological models, where the spatial resolution
does not allow for simulating individual glaciers and data scarcity is an issue.
Although the CMIP5 ensemble results in greater regional warming than the CMIP3
ensemble and the range in projections for temperature as well as precipitation
is wider for the CMIP5 than for the CMIP3, the spread in projections of future
glacier extent in Central Asia is similar for both ensembles. This is because
differences in temperature rise are small during periods of maximum melt (July–September)
while differences in precipitation change are small during the period of maximum
accumulation (October–February). However, the model uncertainty due to parameter
uncertainty is high, and has roughly the same importance as uncertainty in the
climate projections. Uncertainty about the size of the decline in glacier extent
remains large, making estimates of future Central Asian glacier evolution and
downstream water availability uncertain.
article_processing_charge: No
article_type: original
author:
- first_name: A. F.
full_name: Lutz, A. F.
last_name: Lutz
- first_name: W. W.
full_name: Immerzeel, W. W.
last_name: Immerzeel
- first_name: A.
full_name: Gobiet, A.
last_name: Gobiet
- first_name: Francesca
full_name: Pellicciotti, Francesca
id: b28f055a-81ea-11ed-b70c-a9fe7f7b0e70
last_name: Pellicciotti
- first_name: M. F. P.
full_name: Bierkens, M. F. P.
last_name: Bierkens
citation:
ama: Lutz AF, Immerzeel WW, Gobiet A, Pellicciotti F, Bierkens MFP. Comparison of
climate change signals in CMIP3 and CMIP5 multi-model ensembles and implications
for Central Asian glaciers. Hydrology and Earth System Sciences. 2013;17(9):3661-3677.
doi:10.5194/hess-17-3661-2013
apa: Lutz, A. F., Immerzeel, W. W., Gobiet, A., Pellicciotti, F., & Bierkens,
M. F. P. (2013). Comparison of climate change signals in CMIP3 and CMIP5 multi-model
ensembles and implications for Central Asian glaciers. Hydrology and Earth
System Sciences. Copernicus GmbH. https://doi.org/10.5194/hess-17-3661-2013
chicago: Lutz, A. F., W. W. Immerzeel, A. Gobiet, Francesca Pellicciotti, and M.
F. P. Bierkens. “Comparison of Climate Change Signals in CMIP3 and CMIP5 Multi-Model
Ensembles and Implications for Central Asian Glaciers.” Hydrology and Earth
System Sciences. Copernicus GmbH, 2013. https://doi.org/10.5194/hess-17-3661-2013.
ieee: A. F. Lutz, W. W. Immerzeel, A. Gobiet, F. Pellicciotti, and M. F. P. Bierkens,
“Comparison of climate change signals in CMIP3 and CMIP5 multi-model ensembles
and implications for Central Asian glaciers,” Hydrology and Earth System Sciences,
vol. 17, no. 9. Copernicus GmbH, pp. 3661–3677, 2013.
ista: Lutz AF, Immerzeel WW, Gobiet A, Pellicciotti F, Bierkens MFP. 2013. Comparison
of climate change signals in CMIP3 and CMIP5 multi-model ensembles and implications
for Central Asian glaciers. Hydrology and Earth System Sciences. 17(9), 3661–3677.
mla: Lutz, A. F., et al. “Comparison of Climate Change Signals in CMIP3 and CMIP5
Multi-Model Ensembles and Implications for Central Asian Glaciers.” Hydrology
and Earth System Sciences, vol. 17, no. 9, Copernicus GmbH, 2013, pp. 3661–77,
doi:10.5194/hess-17-3661-2013.
short: A.F. Lutz, W.W. Immerzeel, A. Gobiet, F. Pellicciotti, M.F.P. Bierkens, Hydrology
and Earth System Sciences 17 (2013) 3661–3677.
date_created: 2023-02-20T08:17:05Z
date_published: 2013-09-01T00:00:00Z
date_updated: 2023-02-24T08:19:48Z
day: '01'
doi: 10.5194/hess-17-3661-2013
extern: '1'
intvolume: ' 17'
issue: '9'
keyword:
- General Earth and Planetary Sciences
- General Engineering
- General Environmental Science
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.5194/hess-17-3661-2013
month: '09'
oa: 1
oa_version: Published Version
page: 3661-3677
publication: Hydrology and Earth System Sciences
publication_identifier:
issn:
- 1607-7938
publication_status: published
publisher: Copernicus GmbH
quality_controlled: '1'
scopus_import: '1'
status: public
title: Comparison of climate change signals in CMIP3 and CMIP5 multi-model ensembles
and implications for Central Asian glaciers
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2013'
...
---
_id: '12639'
abstract:
- lang: eng
text: 'In the headwater catchments of the main Asian rivers, glaciohydrological
models are a useful tool to anticipate impacts of climatic changes. However, the
reliability of their projections strongly depends on the quality and quantity
of data that are available for parameter estimation, model calibration and validation,
as well as on the accuracy of climate change projections. In this study the physically
oriented, glaciohydrological model TOPKAPI-ETH is used to simulate future changes
in snow, glacier, and runoff from the Hunza River Basin in northern Pakistan.
Three key sources of model uncertainty in future runoff projections are compared:
model parameters, climate projections, and natural climate variability. A novel
approach, applicable also to ungauged catchments, is used to determine which model
parameters and model components significantly affect the overall model uncertainty.
We show that the model is capable of reproducing streamflow and glacier mass balances,
but that all analyzed sources of uncertainty significantly affect the reliability
of future projections, and that their effect is variable in time and in space.
The effect of parametric uncertainty often exceeds the impact of climate uncertainty
and natural climate variability, especially in heavily glacierized subcatchments.
The results of the uncertainty analysis allow detailed recommendations on network
design and the timing and location of field measurements, which could efficiently
help to reduce model uncertainty in the future.'
article_processing_charge: No
article_type: original
author:
- first_name: S.
full_name: Ragettli, S.
last_name: Ragettli
- first_name: Francesca
full_name: Pellicciotti, Francesca
id: b28f055a-81ea-11ed-b70c-a9fe7f7b0e70
last_name: Pellicciotti
- first_name: R.
full_name: Bordoy, R.
last_name: Bordoy
- first_name: W. W.
full_name: Immerzeel, W. W.
last_name: Immerzeel
citation:
ama: Ragettli S, Pellicciotti F, Bordoy R, Immerzeel WW. Sources of uncertainty
in modeling the glaciohydrological response of a Karakoram watershed to climate
change. Water Resources Research. 2013;49(9):6048-6066. doi:10.1002/wrcr.20450
apa: Ragettli, S., Pellicciotti, F., Bordoy, R., & Immerzeel, W. W. (2013).
Sources of uncertainty in modeling the glaciohydrological response of a Karakoram
watershed to climate change. Water Resources Research. American Geophysical
Union. https://doi.org/10.1002/wrcr.20450
chicago: Ragettli, S., Francesca Pellicciotti, R. Bordoy, and W. W. Immerzeel. “Sources
of Uncertainty in Modeling the Glaciohydrological Response of a Karakoram Watershed
to Climate Change.” Water Resources Research. American Geophysical Union,
2013. https://doi.org/10.1002/wrcr.20450.
ieee: S. Ragettli, F. Pellicciotti, R. Bordoy, and W. W. Immerzeel, “Sources of
uncertainty in modeling the glaciohydrological response of a Karakoram watershed
to climate change,” Water Resources Research, vol. 49, no. 9. American
Geophysical Union, pp. 6048–6066, 2013.
ista: Ragettli S, Pellicciotti F, Bordoy R, Immerzeel WW. 2013. Sources of uncertainty
in modeling the glaciohydrological response of a Karakoram watershed to climate
change. Water Resources Research. 49(9), 6048–6066.
mla: Ragettli, S., et al. “Sources of Uncertainty in Modeling the Glaciohydrological
Response of a Karakoram Watershed to Climate Change.” Water Resources Research,
vol. 49, no. 9, American Geophysical Union, 2013, pp. 6048–66, doi:10.1002/wrcr.20450.
short: S. Ragettli, F. Pellicciotti, R. Bordoy, W.W. Immerzeel, Water Resources
Research 49 (2013) 6048–6066.
date_created: 2023-02-20T08:17:12Z
date_published: 2013-03-01T00:00:00Z
date_updated: 2023-02-24T08:16:19Z
day: '01'
doi: 10.1002/wrcr.20450
extern: '1'
intvolume: ' 49'
issue: '9'
keyword:
- Water Science and Technology
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1002/wrcr.20450
month: '03'
oa: 1
oa_version: Published Version
page: 6048-6066
publication: Water Resources Research
publication_identifier:
issn:
- 0043-1397
publication_status: published
publisher: American Geophysical Union
quality_controlled: '1'
scopus_import: '1'
status: public
title: Sources of uncertainty in modeling the glaciohydrological response of a Karakoram
watershed to climate change
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 49
year: '2013'
...
---
_id: '12640'
abstract:
- lang: eng
text: Greater Himalayan glaciers are retreating and losing mass at rates comparable
to glaciers in other regions of the world1,2,3,4,5. Assessments of future changes
and their associated hydrological impacts are scarce, oversimplify glacier dynamics
or include a limited number of climate models6,7,8,9. Here, we use results from
the latest ensemble of climate models in combination with a high-resolution glacio-hydrological
model to assess the hydrological impact of climate change on two climatically
contrasting watersheds in the Greater Himalaya, the Baltoro and Langtang watersheds
that drain into the Indus and Ganges rivers, respectively. We show that the largest
uncertainty in future runoff is a result of variations in projected precipitation
between climate models. In both watersheds, strong, but highly variable, increases
in future runoff are projected and, despite the different characteristics of the
watersheds, their responses are surprisingly similar. In both cases, glaciers
will recede but net glacier melt runoff is on a rising limb at least until 2050.
In combination with a positive change in precipitation, water availability during
this century is not likely to decline. We conclude that river basins that depend
on monsoon rains and glacier melt will continue to sustain the increasing water
demands expected in these areas10.
article_processing_charge: No
article_type: letter_note
author:
- first_name: W. W.
full_name: Immerzeel, W. W.
last_name: Immerzeel
- first_name: Francesca
full_name: Pellicciotti, Francesca
id: b28f055a-81ea-11ed-b70c-a9fe7f7b0e70
last_name: Pellicciotti
- first_name: M. F. P.
full_name: Bierkens, M. F. P.
last_name: Bierkens
citation:
ama: Immerzeel WW, Pellicciotti F, Bierkens MFP. Rising river flows throughout the
twenty-first century in two Himalayan glacierized watersheds. Nature Geoscience.
2013;6(9):742-745. doi:10.1038/ngeo1896
apa: Immerzeel, W. W., Pellicciotti, F., & Bierkens, M. F. P. (2013). Rising
river flows throughout the twenty-first century in two Himalayan glacierized watersheds.
Nature Geoscience. Springer Nature. https://doi.org/10.1038/ngeo1896
chicago: Immerzeel, W. W., Francesca Pellicciotti, and M. F. P. Bierkens. “Rising
River Flows throughout the Twenty-First Century in Two Himalayan Glacierized Watersheds.”
Nature Geoscience. Springer Nature, 2013. https://doi.org/10.1038/ngeo1896.
ieee: W. W. Immerzeel, F. Pellicciotti, and M. F. P. Bierkens, “Rising river flows
throughout the twenty-first century in two Himalayan glacierized watersheds,”
Nature Geoscience, vol. 6, no. 9. Springer Nature, pp. 742–745, 2013.
ista: Immerzeel WW, Pellicciotti F, Bierkens MFP. 2013. Rising river flows throughout
the twenty-first century in two Himalayan glacierized watersheds. Nature Geoscience.
6(9), 742–745.
mla: Immerzeel, W. W., et al. “Rising River Flows throughout the Twenty-First Century
in Two Himalayan Glacierized Watersheds.” Nature Geoscience, vol. 6, no.
9, Springer Nature, 2013, pp. 742–45, doi:10.1038/ngeo1896.
short: W.W. Immerzeel, F. Pellicciotti, M.F.P. Bierkens, Nature Geoscience 6 (2013)
742–745.
date_created: 2023-02-20T08:17:17Z
date_published: 2013-09-13T00:00:00Z
date_updated: 2023-02-21T10:46:37Z
day: '13'
doi: 10.1038/ngeo1896
extern: '1'
intvolume: ' 6'
issue: '9'
keyword:
- General Earth and Planetary Sciences
language:
- iso: eng
month: '09'
oa_version: None
page: 742-745
publication: Nature Geoscience
publication_identifier:
eissn:
- 1752-0908
issn:
- 1752-0894
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Rising river flows throughout the twenty-first century in two Himalayan glacierized
watersheds
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 6
year: '2013'
...
---
_id: '12641'
abstract:
- lang: eng
text: We investigate the sensitivity of a distributed enhanced temperature-index
(ETI) melt model, in order to understand which parameters have the largest influence
on model outputs and thus need to be accurately known. We use melt and meteorological
data from two Alpine glaciers and one glacier in the Andes of Chile. Sensitivity
analysis is conducted in a systematic way in terms of parameters and the different
conditions (day, night, clear-sky, overcast), melt seasons and glaciers examined.
The sensitivity of total melt to changes in individual parameters is calculated
using a local method around the optimal value of the parameters. We verify that
the parameters are optimal at the distributed scale and assess the model uncertainty
induced by uncertainty in the parameters using a Monte Carlo technique. Model
sensitivity to parameters is consistent across melt seasons, glaciers, different
conditions and the daily statistics examined. The parameters to which the model
is most sensitive are the shortwave-radiation factor, the temperature lapse rate
for extrapolation of air temperature, the albedo parameters, the temperature threshold
and the cloud transmittance factor parameters. A parameter uncertainty of 5% results
in a model uncertainty of 5.6% of mean melt on Haut Glacier d’Arolla, Switzerland.
article_processing_charge: No
article_type: original
author:
- first_name: Martin
full_name: Heynen, Martin
last_name: Heynen
- first_name: Francesca
full_name: Pellicciotti, Francesca
id: b28f055a-81ea-11ed-b70c-a9fe7f7b0e70
last_name: Pellicciotti
- first_name: Marco
full_name: Carenzo, Marco
last_name: Carenzo
citation:
ama: Heynen M, Pellicciotti F, Carenzo M. Parameter sensitivity of a distributed
enhanced temperature-index melt model. Annals of Glaciology. 2013;54(63):311-321.
doi:10.3189/2013aog63a537
apa: Heynen, M., Pellicciotti, F., & Carenzo, M. (2013). Parameter sensitivity
of a distributed enhanced temperature-index melt model. Annals of Glaciology.
International Glaciological Society. https://doi.org/10.3189/2013aog63a537
chicago: Heynen, Martin, Francesca Pellicciotti, and Marco Carenzo. “Parameter Sensitivity
of a Distributed Enhanced Temperature-Index Melt Model.” Annals of Glaciology.
International Glaciological Society, 2013. https://doi.org/10.3189/2013aog63a537.
ieee: M. Heynen, F. Pellicciotti, and M. Carenzo, “Parameter sensitivity of a distributed
enhanced temperature-index melt model,” Annals of Glaciology, vol. 54,
no. 63. International Glaciological Society, pp. 311–321, 2013.
ista: Heynen M, Pellicciotti F, Carenzo M. 2013. Parameter sensitivity of a distributed
enhanced temperature-index melt model. Annals of Glaciology. 54(63), 311–321.
mla: Heynen, Martin, et al. “Parameter Sensitivity of a Distributed Enhanced Temperature-Index
Melt Model.” Annals of Glaciology, vol. 54, no. 63, International Glaciological
Society, 2013, pp. 311–21, doi:10.3189/2013aog63a537.
short: M. Heynen, F. Pellicciotti, M. Carenzo, Annals of Glaciology 54 (2013) 311–321.
date_created: 2023-02-20T08:17:21Z
date_published: 2013-08-01T00:00:00Z
date_updated: 2023-02-21T10:43:42Z
day: '01'
doi: 10.3189/2013aog63a537
extern: '1'
intvolume: ' 54'
issue: '63'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.3189/2013aog63a537
month: '08'
oa: 1
oa_version: Published Version
page: 311-321
publication: Annals of Glaciology
publication_identifier:
eissn:
- 1727-5644
issn:
- 0260-3055
publication_status: published
publisher: International Glaciological Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Parameter sensitivity of a distributed enhanced temperature-index melt model
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 54
year: '2013'
...
---
_id: '12642'
abstract:
- lang: eng
text: Near-surface air temperature, typically measured at a height of 2 m, is the
most important control on the energy exchange and the melt rate at a snow or ice
surface. It is distributed in a simplistic manner in most glacier melt models
by using constant linear lapse rates, which poorly represent the actual spatial
and temporal variability of air temperature. In this paper, we test a simple thermodynamic
model proposed by Greuell and Böhm in 1998 as an alternative, using a new dataset
of air temperature measurements from along the flowline of Haut Glacier d’Arolla,
Switzerland. The unmodified model performs little better than assuming a constant
linear lapse rate. When modified to allow the ratio of the boundary layer height
to the bulk heat transfer coefficient to vary along the flowline, the model matches
measured air temperatures better, and a further reduction of the root-mean-square
error is obtained, although there is still considerable scope for improvement.
The modified model is shown to perform best under conditions favourable to the
development of katabatic winds – few clouds, positive ambient air temperature,
limited influence of synoptic or valley winds and a long fetch – but its performance
is poor under cloudy conditions.
article_processing_charge: No
article_type: original
author:
- first_name: Lene
full_name: Petersen, Lene
last_name: Petersen
- first_name: Francesca
full_name: Pellicciotti, Francesca
id: b28f055a-81ea-11ed-b70c-a9fe7f7b0e70
last_name: Pellicciotti
- first_name: Inge
full_name: Juszak, Inge
last_name: Juszak
- first_name: Marco
full_name: Carenzo, Marco
last_name: Carenzo
- first_name: Ben
full_name: Brock, Ben
last_name: Brock
citation:
ama: 'Petersen L, Pellicciotti F, Juszak I, Carenzo M, Brock B. Suitability of a
constant air temperature lapse rate over an Alpine glacier: Testing the Greuell
and Böhm model as an alternative. Annals of Glaciology. 2013;54(63):120-130.
doi:10.3189/2013aog63a477'
apa: 'Petersen, L., Pellicciotti, F., Juszak, I., Carenzo, M., & Brock, B. (2013).
Suitability of a constant air temperature lapse rate over an Alpine glacier: Testing
the Greuell and Böhm model as an alternative. Annals of Glaciology. International
Glaciological Society. https://doi.org/10.3189/2013aog63a477'
chicago: 'Petersen, Lene, Francesca Pellicciotti, Inge Juszak, Marco Carenzo, and
Ben Brock. “Suitability of a Constant Air Temperature Lapse Rate over an Alpine
Glacier: Testing the Greuell and Böhm Model as an Alternative.” Annals of Glaciology.
International Glaciological Society, 2013. https://doi.org/10.3189/2013aog63a477.'
ieee: 'L. Petersen, F. Pellicciotti, I. Juszak, M. Carenzo, and B. Brock, “Suitability
of a constant air temperature lapse rate over an Alpine glacier: Testing the Greuell
and Böhm model as an alternative,” Annals of Glaciology, vol. 54, no. 63.
International Glaciological Society, pp. 120–130, 2013.'
ista: 'Petersen L, Pellicciotti F, Juszak I, Carenzo M, Brock B. 2013. Suitability
of a constant air temperature lapse rate over an Alpine glacier: Testing the Greuell
and Böhm model as an alternative. Annals of Glaciology. 54(63), 120–130.'
mla: 'Petersen, Lene, et al. “Suitability of a Constant Air Temperature Lapse Rate
over an Alpine Glacier: Testing the Greuell and Böhm Model as an Alternative.”
Annals of Glaciology, vol. 54, no. 63, International Glaciological Society,
2013, pp. 120–30, doi:10.3189/2013aog63a477.'
short: L. Petersen, F. Pellicciotti, I. Juszak, M. Carenzo, B. Brock, Annals of
Glaciology 54 (2013) 120–130.
date_created: 2023-02-20T08:17:29Z
date_published: 2013-08-01T00:00:00Z
date_updated: 2023-02-21T10:18:24Z
day: '01'
doi: 10.3189/2013aog63a477
extern: '1'
intvolume: ' 54'
issue: '63'
keyword:
- Earth-Surface Processes
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.3189/2013aog63a477
month: '08'
oa: 1
oa_version: Published Version
page: 120-130
publication: Annals of Glaciology
publication_identifier:
eissn:
- 1727-5644
issn:
- 0260-3055
publication_status: published
publisher: International Glaciological Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Suitability of a constant air temperature lapse rate over an Alpine glacier:
Testing the Greuell and Böhm model as an alternative'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 54
year: '2013'
...
---
_id: '12643'
abstract:
- lang: eng
text: Parameterizations of incoming longwave radiation are increasingly receiving
attention for both low and high elevation glacierized sites. In this paper, we
test 13 clear-sky parameterizations combined with seven cloud corrections for
all-sky atmospheric emissivity at one location on Haut Glacier d'Arolla. We also
analyze the four seasons separately and conduct a cross-validation to test the
parameters’ robustness. The best parameterization is the one by Dilley and O'Brien,
B for clear-sky conditions combined with Unsworth and Monteith cloud correction.
This model is also the most robust when tested in cross-validation. When validated
at different sites in the southern Alps of Switzerland and north-western Italian
Alps, all parameterizations show a substantial decrease in performance, except
for one site, thus suggesting that it is important to recalibrate parameterizations
of incoming longwave radiation for different locations. We argue that this is
due to differences in the structure of the atmosphere at the sites. We also quantify
the effect that the incoming longwave radiation parameterizations have on energy-balance
melt modeling, and show that recalibration of model parameters is needed. Using
parameters from other sites leads to a significant underestimation of melt and
to an error that is larger than that associated with using different parameterizations.
Once recalibrated, however, the parameters of most models seem to be stable over
seasons and years at the location on Haut Glacier d'Arolla.
article_processing_charge: No
article_type: original
author:
- first_name: I.
full_name: Juszak, I.
last_name: Juszak
- first_name: Francesca
full_name: Pellicciotti, Francesca
id: b28f055a-81ea-11ed-b70c-a9fe7f7b0e70
last_name: Pellicciotti
citation:
ama: 'Juszak I, Pellicciotti F. A comparison of parameterizations of incoming longwave
radiation over melting glaciers: Model robustness and seasonal variability. Journal
of Geophysical Research: Atmospheres. 2013;118(8):3066-3084. doi:10.1002/jgrd.50277'
apa: 'Juszak, I., & Pellicciotti, F. (2013). A comparison of parameterizations
of incoming longwave radiation over melting glaciers: Model robustness and seasonal
variability. Journal of Geophysical Research: Atmospheres. American Geophysical
Union. https://doi.org/10.1002/jgrd.50277'
chicago: 'Juszak, I., and Francesca Pellicciotti. “A Comparison of Parameterizations
of Incoming Longwave Radiation over Melting Glaciers: Model Robustness and Seasonal
Variability.” Journal of Geophysical Research: Atmospheres. American Geophysical
Union, 2013. https://doi.org/10.1002/jgrd.50277.'
ieee: 'I. Juszak and F. Pellicciotti, “A comparison of parameterizations of incoming
longwave radiation over melting glaciers: Model robustness and seasonal variability,”
Journal of Geophysical Research: Atmospheres, vol. 118, no. 8. American
Geophysical Union, pp. 3066–3084, 2013.'
ista: 'Juszak I, Pellicciotti F. 2013. A comparison of parameterizations of incoming
longwave radiation over melting glaciers: Model robustness and seasonal variability.
Journal of Geophysical Research: Atmospheres. 118(8), 3066–3084.'
mla: 'Juszak, I., and Francesca Pellicciotti. “A Comparison of Parameterizations
of Incoming Longwave Radiation over Melting Glaciers: Model Robustness and Seasonal
Variability.” Journal of Geophysical Research: Atmospheres, vol. 118, no.
8, American Geophysical Union, 2013, pp. 3066–84, doi:10.1002/jgrd.50277.'
short: 'I. Juszak, F. Pellicciotti, Journal of Geophysical Research: Atmospheres
118 (2013) 3066–3084.'
date_created: 2023-02-20T08:17:34Z
date_published: 2013-04-27T00:00:00Z
date_updated: 2023-02-21T10:10:46Z
day: '27'
doi: 10.1002/jgrd.50277
extern: '1'
intvolume: ' 118'
issue: '8'
keyword:
- Space and Planetary Science
- Earth and Planetary Sciences (miscellaneous)
- Atmospheric Science
- Geophysics
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1002/jgrd.50277
month: '04'
oa: 1
oa_version: Published Version
page: 3066-3084
publication: 'Journal of Geophysical Research: Atmospheres'
publication_identifier:
issn:
- 2169-897X
publication_status: published
publisher: American Geophysical Union
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'A comparison of parameterizations of incoming longwave radiation over melting
glaciers: Model robustness and seasonal variability'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 118
year: '2013'
...
---
_id: '1304'
abstract:
- lang: eng
text: When confronted with a large-field stimulus rotating around the vertical body
axis, flies display a following behavior called "optomotor response."
As neural control elements, the large tangential horizontal system (HS) cells
of the lobula plate have been prime candidates for long. Here, we applied optogenetic
stimulation of HS cells to evaluate their behavioral role in Drosophila. To minimize
interference of the optical activation of channelrhodopsin-2 with the visual perception
of the flies, we used a bistable variant called ChR2-C128S. By applying pulses
of blue and yellow light, we first demonstrate electrophysiologically that lobula
plate tangential cells can be activated and deactivated repeatedly with no evident
change in depolarization strength over trials. We next show that selective optogenetic
activation of HS cells elicits robust yaw head movements and yaw turning responses
in fixed and tethered flying flies, respectively.
acknowledgement: 'This work was supported by the Max Planck Society. '
author:
- first_name: Väinö
full_name: Haikala, Väinö
last_name: Haikala
- first_name: Maximilian A
full_name: Maximilian Jösch
id: 2BD278E6-F248-11E8-B48F-1D18A9856A87
last_name: Jösch
orcid: 0000-0002-3937-1330
- first_name: Alexander
full_name: Borst, Alexander
last_name: Borst
- first_name: Alex
full_name: Mauss, Alex S
last_name: Mauss
citation:
ama: Haikala V, Jösch MA, Borst A, Mauss A. Optogenetic control of fly optomotor
responses. Journal of Neuroscience. 2013;33(34):13927-13934. doi:10.1523/JNEUROSCI.0340-13.2013
apa: Haikala, V., Jösch, M. A., Borst, A., & Mauss, A. (2013). Optogenetic control
of fly optomotor responses. Journal of Neuroscience. Society for Neuroscience.
https://doi.org/10.1523/JNEUROSCI.0340-13.2013
chicago: Haikala, Väinö, Maximilian A Jösch, Alexander Borst, and Alex Mauss. “Optogenetic
Control of Fly Optomotor Responses.” Journal of Neuroscience. Society for
Neuroscience, 2013. https://doi.org/10.1523/JNEUROSCI.0340-13.2013.
ieee: V. Haikala, M. A. Jösch, A. Borst, and A. Mauss, “Optogenetic control of fly
optomotor responses,” Journal of Neuroscience, vol. 33, no. 34. Society
for Neuroscience, pp. 13927–13934, 2013.
ista: Haikala V, Jösch MA, Borst A, Mauss A. 2013. Optogenetic control of fly optomotor
responses. Journal of Neuroscience. 33(34), 13927–13934.
mla: Haikala, Väinö, et al. “Optogenetic Control of Fly Optomotor Responses.” Journal
of Neuroscience, vol. 33, no. 34, Society for Neuroscience, 2013, pp. 13927–34,
doi:10.1523/JNEUROSCI.0340-13.2013.
short: V. Haikala, M.A. Jösch, A. Borst, A. Mauss, Journal of Neuroscience 33 (2013)
13927–13934.
date_created: 2018-12-11T11:51:16Z
date_published: 2013-01-01T00:00:00Z
date_updated: 2021-01-12T06:49:45Z
day: '01'
doi: 10.1523/JNEUROSCI.0340-13.2013
extern: 1
intvolume: ' 33'
issue: '34'
month: '01'
page: 13927 - 13934
publication: Journal of Neuroscience
publication_status: published
publisher: Society for Neuroscience
publist_id: '5967'
quality_controlled: 0
status: public
title: Optogenetic control of fly optomotor responses
type: journal_article
volume: 33
year: '2013'
...
---
_id: '1305'
abstract:
- lang: eng
text: In the fly Drosophila melanogaster, photoreceptor input to motion vision is
split into two parallel pathways as represented by first-order interneurons L1
and L2 (Rister et al., 2007; Joesch et al., 2010). However, how these pathways
are functionally specialized remains controversial. One study (Eichner et al.,
2011) proposed that the L1-pathway evaluates only sequences of brightness increments
(ON-ON), while the L2-pathway processes exclusively brightness decrements (OFF-OFF).
Another study (Clark et al., 2011) proposed that each of the two pathways evaluates
both ON-ON and OFF-OFF sequences. To decide between these alternatives, we recorded
from motionsensitive neurons in flies in which the output from either L1 or L2
was genetically blocked. We found that blocking L1 abolishes ON-ON responses but
leaves OFF-OFF responses intact. The opposite was true, when the output from L2
was blocked. We conclude that the L1 and L2 pathways are functionally specialized
to detect ON-ON and OFF-OFF sequences, respectively.
acknowledgement: This work was supported by the Max-Planck-Society and the SFB 870
of the Deutsche Forschungsgemeinschaft.
author:
- first_name: Maximilian A
full_name: Maximilian Jösch
id: 2BD278E6-F248-11E8-B48F-1D18A9856A87
last_name: Jösch
orcid: 0000-0002-3937-1330
- first_name: Franz
full_name: Weber, Franz
last_name: Weber
- first_name: Hubert
full_name: Eichner, Hubert
last_name: Eichner
- first_name: Alexander
full_name: Borst, Alexander
last_name: Borst
citation:
ama: Jösch MA, Weber F, Eichner H, Borst A. Functional specialization of parallel
motion detection circuits in the fly. Journal of Neuroscience. 2013;33(3):902-905.
doi:10.1523/JNEUROSCI.3374-12.2013
apa: Jösch, M. A., Weber, F., Eichner, H., & Borst, A. (2013). Functional specialization
of parallel motion detection circuits in the fly. Journal of Neuroscience.
Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.3374-12.2013
chicago: Jösch, Maximilian A, Franz Weber, Hubert Eichner, and Alexander Borst.
“Functional Specialization of Parallel Motion Detection Circuits in the Fly.”
Journal of Neuroscience. Society for Neuroscience, 2013. https://doi.org/10.1523/JNEUROSCI.3374-12.2013.
ieee: M. A. Jösch, F. Weber, H. Eichner, and A. Borst, “Functional specialization
of parallel motion detection circuits in the fly,” Journal of Neuroscience,
vol. 33, no. 3. Society for Neuroscience, pp. 902–905, 2013.
ista: Jösch MA, Weber F, Eichner H, Borst A. 2013. Functional specialization of
parallel motion detection circuits in the fly. Journal of Neuroscience. 33(3),
902–905.
mla: Jösch, Maximilian A., et al. “Functional Specialization of Parallel Motion
Detection Circuits in the Fly.” Journal of Neuroscience, vol. 33, no. 3,
Society for Neuroscience, 2013, pp. 902–05, doi:10.1523/JNEUROSCI.3374-12.2013.
short: M.A. Jösch, F. Weber, H. Eichner, A. Borst, Journal of Neuroscience 33 (2013)
902–905.
date_created: 2018-12-11T11:51:16Z
date_published: 2013-01-16T00:00:00Z
date_updated: 2021-01-12T06:49:45Z
day: '16'
doi: 10.1523/JNEUROSCI.3374-12.2013
extern: 1
intvolume: ' 33'
issue: '3'
month: '01'
page: 902 - 905
publication: Journal of Neuroscience
publication_status: published
publisher: Society for Neuroscience
publist_id: '5968'
quality_controlled: 0
status: public
title: Functional specialization of parallel motion detection circuits in the fly
type: journal_article
volume: 33
year: '2013'
...
---
_id: '1307'
abstract:
- lang: eng
text: We prove uniqueness of solutions of the DLSS equation in a class of sufficiently
regular functions. The global weak solutions of the DLSS equation constructed
by Jüngel and Matthes belong to this class of uniqueness. We also show uniqueness
of solutions for the quantum drift-diffusion equation, which contains additional
drift and second-order diffusion terms. The results hold in case of periodic or
Dirichlet-Neumann boundary conditions. Our proof is based on a monotonicity property
of the DLSS operator and sophisticated approximation arguments; we derive a PDE
satisfied by the pointwise square root of the solution, which enables us to exploit
the monotonicity property of the operator.
author:
- first_name: Julian L
full_name: Julian Fischer
id: 2C12A0B0-F248-11E8-B48F-1D18A9856A87
last_name: Fischer
orcid: 0000-0002-0479-558X
citation:
ama: Fischer JL. Uniqueness of solutions of the Derrida-Lebowitz-Speer-Spohn equation
and quantum drift diffusion models. Communications in Partial Differential
Equations. 2013;38(11):2004-2047. doi:10.1080/03605302.2013.823548
apa: Fischer, J. L. (2013). Uniqueness of solutions of the Derrida-Lebowitz-Speer-Spohn
equation and quantum drift diffusion models. Communications in Partial Differential
Equations. Taylor & Francis. https://doi.org/10.1080/03605302.2013.823548
chicago: Fischer, Julian L. “Uniqueness of Solutions of the Derrida-Lebowitz-Speer-Spohn
Equation and Quantum Drift Diffusion Models.” Communications in Partial Differential
Equations. Taylor & Francis, 2013. https://doi.org/10.1080/03605302.2013.823548.
ieee: J. L. Fischer, “Uniqueness of solutions of the Derrida-Lebowitz-Speer-Spohn
equation and quantum drift diffusion models,” Communications in Partial Differential
Equations, vol. 38, no. 11. Taylor & Francis, pp. 2004–2047, 2013.
ista: Fischer JL. 2013. Uniqueness of solutions of the Derrida-Lebowitz-Speer-Spohn
equation and quantum drift diffusion models. Communications in Partial Differential
Equations. 38(11), 2004–2047.
mla: Fischer, Julian L. “Uniqueness of Solutions of the Derrida-Lebowitz-Speer-Spohn
Equation and Quantum Drift Diffusion Models.” Communications in Partial Differential
Equations, vol. 38, no. 11, Taylor & Francis, 2013, pp. 2004–47, doi:10.1080/03605302.2013.823548.
short: J.L. Fischer, Communications in Partial Differential Equations 38 (2013)
2004–2047.
date_created: 2018-12-11T11:51:17Z
date_published: 2013-11-01T00:00:00Z
date_updated: 2021-01-12T06:49:46Z
day: '01'
doi: 10.1080/03605302.2013.823548
extern: 1
intvolume: ' 38'
issue: '11'
month: '11'
page: 2004 - 2047
publication: Communications in Partial Differential Equations
publication_status: published
publisher: Taylor & Francis
publist_id: '5962'
quality_controlled: 0
status: public
title: Uniqueness of solutions of the Derrida-Lebowitz-Speer-Spohn equation and quantum
drift diffusion models
type: journal_article
volume: 38
year: '2013'
...
---
_id: '1308'
abstract:
- lang: eng
text: We derive sufficient conditions for advection-driven backward motion of the
free boundary in a chemotaxis model with degenerate mobility. In this model, a
porous-medium-type diffusive term and an advection term are in competition. The
former induces forward motion, the latter may induce backward motion of the free
boundary depending on the direction of advection. We deduce conditions on the
growth of the initial data at the free boundary which ensure that at least initially
the advection term is dominant. This implies local backward motion of the free
boundary provided the advection is (locally) directed appropriately. Our result
is based on a new class of moving test functions and Stampacchia's lemma. As a
by-product of our estimates, we obtain quantitative bounds on the spreading of
the support of solutions for the chemotaxis model and provide a proof for the
finite speed of the support propagation property of solutions.
author:
- first_name: Julian L
full_name: Julian Fischer
id: 2C12A0B0-F248-11E8-B48F-1D18A9856A87
last_name: Fischer
orcid: 0000-0002-0479-558X
citation:
ama: Fischer JL. Advection-driven support shrinking in a chemotaxis model with degenerate
mobility. SIAM Journal on Mathematical Analysis. 2013;45(3):1585-1615.
doi:10.1137/120874291
apa: Fischer, J. L. (2013). Advection-driven support shrinking in a chemotaxis model
with degenerate mobility. SIAM Journal on Mathematical Analysis. Society
for Industrial and Applied Mathematics . https://doi.org/10.1137/120874291
chicago: Fischer, Julian L. “Advection-Driven Support Shrinking in a Chemotaxis
Model with Degenerate Mobility.” SIAM Journal on Mathematical Analysis.
Society for Industrial and Applied Mathematics , 2013. https://doi.org/10.1137/120874291.
ieee: J. L. Fischer, “Advection-driven support shrinking in a chemotaxis model with
degenerate mobility,” SIAM Journal on Mathematical Analysis, vol. 45, no.
3. Society for Industrial and Applied Mathematics , pp. 1585–1615, 2013.
ista: Fischer JL. 2013. Advection-driven support shrinking in a chemotaxis model
with degenerate mobility. SIAM Journal on Mathematical Analysis. 45(3), 1585–1615.
mla: Fischer, Julian L. “Advection-Driven Support Shrinking in a Chemotaxis Model
with Degenerate Mobility.” SIAM Journal on Mathematical Analysis, vol.
45, no. 3, Society for Industrial and Applied Mathematics , 2013, pp. 1585–615,
doi:10.1137/120874291.
short: J.L. Fischer, SIAM Journal on Mathematical Analysis 45 (2013) 1585–1615.
date_created: 2018-12-11T11:51:17Z
date_published: 2013-01-01T00:00:00Z
date_updated: 2021-01-12T06:49:46Z
day: '01'
doi: 10.1137/120874291
extern: 1
intvolume: ' 45'
issue: '3'
month: '01'
page: 1585 - 1615
publication: SIAM Journal on Mathematical Analysis
publication_status: published
publisher: 'Society for Industrial and Applied Mathematics '
publist_id: '5963'
quality_controlled: 0
status: public
title: Advection-driven support shrinking in a chemotaxis model with degenerate mobility
type: journal_article
volume: 45
year: '2013'
...
---
_id: '1310'
abstract:
- lang: eng
text: We derive lower bounds on asymptotic support propagation rates for strong
solutions of the Cauchy problem for the thin-film equation. The bounds coincide
up to a constant factor with the previously known upper bounds and thus are sharp.
Our results hold in case of at most three spatial dimensions and n∈. (1, 2.92).
The result is established using weighted backward entropy inequalities with singular
weight functions to yield a differential inequality; combined with some entropy
production estimates, the optimal rate of propagation is obtained. To the best
of our knowledge, these are the first lower bounds on asymptotic support propagation
rates for higher-order nonnegativity-preserving parabolic equations.
author:
- first_name: Julian L
full_name: Julian Fischer
id: 2C12A0B0-F248-11E8-B48F-1D18A9856A87
last_name: Fischer
orcid: 0000-0002-0479-558X
citation:
ama: Fischer JL. Optimal lower bounds on asymptotic support propagation rates for
the thin-film equation. Journal of Differential Equations. 2013;255(10):3127-3149.
doi:10.1016/j.jde.2013.07.028
apa: Fischer, J. L. (2013). Optimal lower bounds on asymptotic support propagation
rates for the thin-film equation. Journal of Differential Equations. Academic
Press. https://doi.org/10.1016/j.jde.2013.07.028
chicago: Fischer, Julian L. “Optimal Lower Bounds on Asymptotic Support Propagation
Rates for the Thin-Film Equation.” Journal of Differential Equations. Academic
Press, 2013. https://doi.org/10.1016/j.jde.2013.07.028.
ieee: J. L. Fischer, “Optimal lower bounds on asymptotic support propagation rates
for the thin-film equation,” Journal of Differential Equations, vol. 255,
no. 10. Academic Press, pp. 3127–3149, 2013.
ista: Fischer JL. 2013. Optimal lower bounds on asymptotic support propagation rates
for the thin-film equation. Journal of Differential Equations. 255(10), 3127–3149.
mla: Fischer, Julian L. “Optimal Lower Bounds on Asymptotic Support Propagation
Rates for the Thin-Film Equation.” Journal of Differential Equations, vol.
255, no. 10, Academic Press, 2013, pp. 3127–49, doi:10.1016/j.jde.2013.07.028.
short: J.L. Fischer, Journal of Differential Equations 255 (2013) 3127–3149.
date_created: 2018-12-11T11:51:18Z
date_published: 2013-11-15T00:00:00Z
date_updated: 2021-01-12T06:49:47Z
day: '15'
doi: 10.1016/j.jde.2013.07.028
extern: 1
intvolume: ' 255'
issue: '10'
month: '11'
page: 3127 - 3149
publication: Journal of Differential Equations
publication_status: published
publisher: Academic Press
publist_id: '5961'
quality_controlled: 0
status: public
title: Optimal lower bounds on asymptotic support propagation rates for the thin-film
equation
type: journal_article
volume: 255
year: '2013'
...
---
_id: '8245'
abstract:
- lang: eng
text: "Background: Monoclonal antibodies (mAb), such as trastuzumab are a valuable
addition to breast cancer therapy.\r\nData obtained from neoadjuvant settings
revealed that antibody-dependent cell-mediated cytotoxicity (ADCC) is a\r\nmajor
mechanism of action for the mAb trastuzumab. Conflicting results still call into
question whether disease\r\nprogression, prolonged treatment or concomitant chemotherapy
influences ADCC and related immunological\r\nphenomena.\r\nMethods: We analyzed
the activity of ADCC and antibody-dependent cell-mediated phagocytosis (ADCP)
of\r\nperipheral blood mononuclear cells (PBMCs) from human epidermal growth factor
receptor 2 (HER2/neu) positive\r\nbreast cancer patients receiving trastuzumab
therapy either in an adjuvant (n = 13) or metastatic (n = 15) setting as\r\nwell
as from trastuzumab treatment-naive (t-naive) HER2/neu negative patients (n =
15). PBMCs from healthy volunteers\r\n(n = 24) were used as controls. ADCC and
ADCP activity was correlated with the expression of antibody binding\r\nFc-gamma
receptor (FcγR)I (CD64), FcγRII (CD32) and FcγRIII (CD16) on CD14+ (monocytes)
and CD56+ (NK) cells, as well as the expression of CD107a+ (LAMP-1) on CD56+ cells
and the total amount of CD4+CD25+FOXP3+ (Treg) cells. In metastatic patients,
markers were correlated with progression-free survival (PFS).\r\nResults: ADCC
activity was significantly down regulated in metastatic, adjuvant and t-naive
patient cohorts as compared to healthy controls. Reduced ADCC activity was inversely
correlated with the expression of CD107a on CD56+\r\ncells in adjuvant patients.
ADCC and ADCP activity of the patient cohorts were similar, regardless of treatment
duration\r\nor additional chemotherapy. PFS in metastatic patients inversely correlated
with the number of peripheral Treg cells.\r\nConclusion: The reduction of ADCC
in patients as compared to healthy controls calls for adjuvant strategies, such
as\r\nimmune-enhancing agents, to improve the activity of trastuzumab. However,
efficacy of trastuzumab-specific ADCC\r\nand ADCP appears not to be affected by
treatment duration, disease progression or concomitant chemotherapy. This\r\nfinding
supports the application of trastuzumab at any stage of the disease."
article_number: '307'
article_processing_charge: No
author:
- first_name: Branka
full_name: Petricevic, Branka
last_name: Petricevic
- first_name: Johannes
full_name: Laengle, Johannes
last_name: Laengle
- first_name: Josef
full_name: Singer, Josef
last_name: Singer
- first_name: Monika
full_name: Sachet, Monika
last_name: Sachet
- first_name: Judit
full_name: Fazekas, Judit
id: 36432834-F248-11E8-B48F-1D18A9856A87
last_name: Fazekas
orcid: 0000-0002-8777-3502
- first_name: Guenther
full_name: Steger, Guenther
last_name: Steger
- first_name: Rupert
full_name: Bartsch, Rupert
last_name: Bartsch
- first_name: Erika
full_name: Jensen-Jarolim, Erika
last_name: Jensen-Jarolim
- first_name: Michael
full_name: Bergmann, Michael
last_name: Bergmann
citation:
ama: Petricevic B, Laengle J, Singer J, et al. Trastuzumab mediates antibody-dependent
cell-mediated cytotoxicity and phagocytosis to the same extent in both adjuvant
and metastatic HER2/neu breast cancer patients. Journal of Translational Medicine.
2013;11. doi:10.1186/1479-5876-11-307
apa: Petricevic, B., Laengle, J., Singer, J., Sachet, M., Singer, J., Steger, G.,
… Bergmann, M. (2013). Trastuzumab mediates antibody-dependent cell-mediated cytotoxicity
and phagocytosis to the same extent in both adjuvant and metastatic HER2/neu breast
cancer patients. Journal of Translational Medicine. Springer Nature. https://doi.org/10.1186/1479-5876-11-307
chicago: Petricevic, Branka, Johannes Laengle, Josef Singer, Monika Sachet, Judit
Singer, Guenther Steger, Rupert Bartsch, Erika Jensen-Jarolim, and Michael Bergmann.
“Trastuzumab Mediates Antibody-Dependent Cell-Mediated Cytotoxicity and Phagocytosis
to the Same Extent in Both Adjuvant and Metastatic HER2/Neu Breast Cancer Patients.”
Journal of Translational Medicine. Springer Nature, 2013. https://doi.org/10.1186/1479-5876-11-307.
ieee: B. Petricevic et al., “Trastuzumab mediates antibody-dependent cell-mediated
cytotoxicity and phagocytosis to the same extent in both adjuvant and metastatic
HER2/neu breast cancer patients,” Journal of Translational Medicine, vol.
11. Springer Nature, 2013.
ista: Petricevic B, Laengle J, Singer J, Sachet M, Singer J, Steger G, Bartsch R,
Jensen-Jarolim E, Bergmann M. 2013. Trastuzumab mediates antibody-dependent cell-mediated
cytotoxicity and phagocytosis to the same extent in both adjuvant and metastatic
HER2/neu breast cancer patients. Journal of Translational Medicine. 11, 307.
mla: Petricevic, Branka, et al. “Trastuzumab Mediates Antibody-Dependent Cell-Mediated
Cytotoxicity and Phagocytosis to the Same Extent in Both Adjuvant and Metastatic
HER2/Neu Breast Cancer Patients.” Journal of Translational Medicine, vol.
11, 307, Springer Nature, 2013, doi:10.1186/1479-5876-11-307.
short: B. Petricevic, J. Laengle, J. Singer, M. Sachet, J. Singer, G. Steger, R.
Bartsch, E. Jensen-Jarolim, M. Bergmann, Journal of Translational Medicine 11
(2013).
date_created: 2020-08-10T11:54:34Z
date_published: 2013-12-12T00:00:00Z
date_updated: 2022-08-25T14:52:39Z
day: '12'
ddc:
- '570'
doi: 10.1186/1479-5876-11-307
extern: '1'
external_id:
pmid:
- '24330813'
file:
- access_level: open_access
content_type: application/pdf
creator: dernst
date_created: 2020-08-10T13:45:19Z
date_updated: 2020-08-10T13:45:19Z
file_id: '8247'
file_name: 2013_JoTM_Petricevic.pdf
file_size: 777311
relation: main_file
success: 1
file_date_updated: 2020-08-10T13:45:19Z
has_accepted_license: '1'
intvolume: ' 11'
language:
- iso: eng
month: '12'
oa: 1
oa_version: None
pmid: 1
publication: Journal of Translational Medicine
publication_identifier:
issn:
- 1479-5876
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Trastuzumab mediates antibody-dependent cell-mediated cytotoxicity and phagocytosis
to the same extent in both adjuvant and metastatic HER2/neu breast cancer patients
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/3.0/legalcode
name: Creative Commons Attribution 3.0 Unported (CC BY 3.0)
short: CC BY (3.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 11
year: '2013'
...
---
_id: '827'
abstract:
- lang: eng
text: As sessile organisms, plants have to be able to adapt to a continuously changing
environment. Plants that perceive some of these changes as stress signals activate
signaling pathways to modulate their development and to enable them to survive.
The complex responses to environmental cues are to a large extent mediated by
plant hormones that together orchestrate the final plant response. The phytohormone
cytokinin is involved in many plant developmental processes. Recently, it has
been established that cytokinin plays an important role in stress responses, but
does not act alone. Indeed, the hormonal control of plant development and stress
adaptation is the outcome of a complex network of multiple synergistic and antagonistic
interactions between various hormones. Here, we review the recent findings on
the cytokinin function as part of this hormonal network. We focus on the importance
of the crosstalk between cytokinin and other hormones, such as abscisic acid,
jasmonate, salicylic acid, ethylene, and auxin in the modulation of plant development
and stress adaptation. Finally, the impact of the current research in the biotechnological
industry will be discussed.
article_number: '451'
author:
- first_name: José
full_name: O'Brien, José
last_name: O'Brien
- first_name: Eva
full_name: Benková, Eva
id: 38F4F166-F248-11E8-B48F-1D18A9856A87
last_name: Benková
orcid: 0000-0002-8510-9739
citation:
ama: O’Brien J, Benková E. Cytokinin cross talking during biotic and abiotic stress
responses. Frontiers in Plant Science. 2013;4. doi:10.3389/fpls.2013.00451
apa: O’Brien, J., & Benková, E. (2013). Cytokinin cross talking during biotic
and abiotic stress responses. Frontiers in Plant Science. Frontiers Research
Foundation. https://doi.org/10.3389/fpls.2013.00451
chicago: O’Brien, José, and Eva Benková. “Cytokinin Cross Talking during Biotic
and Abiotic Stress Responses.” Frontiers in Plant Science. Frontiers Research
Foundation, 2013. https://doi.org/10.3389/fpls.2013.00451.
ieee: J. O’Brien and E. Benková, “Cytokinin cross talking during biotic and abiotic
stress responses,” Frontiers in Plant Science, vol. 4. Frontiers Research
Foundation, 2013.
ista: O’Brien J, Benková E. 2013. Cytokinin cross talking during biotic and abiotic
stress responses. Frontiers in Plant Science. 4, 451.
mla: O’Brien, José, and Eva Benková. “Cytokinin Cross Talking during Biotic and
Abiotic Stress Responses.” Frontiers in Plant Science, vol. 4, 451, Frontiers
Research Foundation, 2013, doi:10.3389/fpls.2013.00451.
short: J. O’Brien, E. Benková, Frontiers in Plant Science 4 (2013).
date_created: 2018-12-11T11:48:43Z
date_published: 2013-11-19T00:00:00Z
date_updated: 2021-01-12T08:17:50Z
day: '19'
ddc:
- '580'
department:
- _id: EvBe
doi: 10.3389/fpls.2013.00451
ec_funded: 1
file:
- access_level: open_access
checksum: fdc25ddd1bf9a99b99f662cdbafeddd4
content_type: application/pdf
creator: dernst
date_created: 2019-01-31T10:40:38Z
date_updated: 2020-07-14T12:48:11Z
file_id: '5903'
file_name: 2013_FrontiersPlant_OBrien.pdf
file_size: 953299
relation: main_file
file_date_updated: 2020-07-14T12:48:11Z
has_accepted_license: '1'
intvolume: ' 4'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
project:
- _id: 253FCA6A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '207362'
name: Hormonal cross-talk in plant organogenesis
publication: Frontiers in Plant Science
publication_status: published
publisher: Frontiers Research Foundation
publist_id: '6821'
quality_controlled: '1'
scopus_import: 1
status: public
title: Cytokinin cross talking during biotic and abiotic stress responses
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 4
year: '2013'
...
---
_id: '828'
abstract:
- lang: eng
text: The plant root system is essential for providing anchorage to the soil, supplying
minerals and water, and synthesizing metabolites. It is a dynamic organ modulated
by external cues such as environmental signals, water and nutrients availability,
salinity and others. Lateral roots (LRs) are initiated from the primary root post-embryonically,
after which they progress through discrete developmental stages which can be independently
controlled, providing a high level of plasticity during root system formation.
Within this review, main contributions are presented, from the classical forward
genetic screens to the more recent high-throughput approaches, combined with computer
model predictions, dissecting how LRs and thereby root system architecture is
established and developed.
article_number: '537'
author:
- first_name: Candela
full_name: Cuesta, Candela
id: 33A3C818-F248-11E8-B48F-1D18A9856A87
last_name: Cuesta
orcid: 0000-0003-1923-2410
- first_name: Krzysztof T
full_name: Wabnik, Krzysztof T
id: 4DE369A4-F248-11E8-B48F-1D18A9856A87
last_name: Wabnik
orcid: 0000-0001-7263-0560
- first_name: Eva
full_name: Benková, Eva
id: 38F4F166-F248-11E8-B48F-1D18A9856A87
last_name: Benková
orcid: 0000-0002-8510-9739
citation:
ama: Cuesta C, Wabnik KT, Benková E. Systems approaches to study root architecture
dynamics. Frontiers in Plant Science. 2013;4. doi:10.3389/fpls.2013.00537
apa: Cuesta, C., Wabnik, K. T., & Benková, E. (2013). Systems approaches to
study root architecture dynamics. Frontiers in Plant Science. Frontiers
Research Foundation. https://doi.org/10.3389/fpls.2013.00537
chicago: Cuesta, Candela, Krzysztof T Wabnik, and Eva Benková. “Systems Approaches
to Study Root Architecture Dynamics.” Frontiers in Plant Science. Frontiers
Research Foundation, 2013. https://doi.org/10.3389/fpls.2013.00537.
ieee: C. Cuesta, K. T. Wabnik, and E. Benková, “Systems approaches to study root
architecture dynamics,” Frontiers in Plant Science, vol. 4. Frontiers Research
Foundation, 2013.
ista: Cuesta C, Wabnik KT, Benková E. 2013. Systems approaches to study root architecture
dynamics. Frontiers in Plant Science. 4, 537.
mla: Cuesta, Candela, et al. “Systems Approaches to Study Root Architecture Dynamics.”
Frontiers in Plant Science, vol. 4, 537, Frontiers Research Foundation,
2013, doi:10.3389/fpls.2013.00537.
short: C. Cuesta, K.T. Wabnik, E. Benková, Frontiers in Plant Science 4 (2013).
date_created: 2018-12-11T11:48:43Z
date_published: 2013-12-26T00:00:00Z
date_updated: 2021-01-12T08:17:52Z
day: '26'
ddc:
- '580'
department:
- _id: EvBe
doi: 10.3389/fpls.2013.00537
ec_funded: 1
file:
- access_level: open_access
checksum: 0185b3c4d7df9a94bd3ce5a66d213506
content_type: application/pdf
creator: dernst
date_created: 2019-01-31T10:36:43Z
date_updated: 2020-07-14T12:48:11Z
file_id: '5902'
file_name: 2013_FrontiersPlant_Cuesta.pdf
file_size: 710835
relation: main_file
file_date_updated: 2020-07-14T12:48:11Z
has_accepted_license: '1'
intvolume: ' 4'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
project:
- _id: 253FCA6A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '207362'
name: Hormonal cross-talk in plant organogenesis
publication: Frontiers in Plant Science
publication_status: published
publisher: Frontiers Research Foundation
publist_id: '6820'
quality_controlled: '1'
scopus_import: 1
status: public
title: Systems approaches to study root architecture dynamics
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 4
year: '2013'
...
---
_id: '830'
abstract:
- lang: eng
text: Upon hormonal signaling, ovules develop as lateral organs from the placenta.
Ovule numbers ultimately determine the number of seeds that develop, and thereby
contribute to the final seed yield in crop plants. We demonstrate here that CUP-SHAPED
COTYLEDON 1 (CUC1), CUC2 and AINTEGUMENTA (ANT) have additive effects on ovule
primordia formation. We show that expression of the CUC1 and CUC2 genes is required
to redundantly regulate expression of PINFORMED1 (PIN1), which in turn is required
for ovule primordia formation. Furthermore, our results suggest that the auxin
response factor MONOPTEROS (MP/ARF5) may directly bind ANT, CUC1 and CUC2 and
promote their transcription. Based on our findings, we propose an integrative
model to describe the molecular mechanisms of the early stages of ovule development.
acknowledgement: The project and F.G. were supported by the CARIPLO Foundation (project
2009-2990) and COST (European Cooperation in Science and Technology) action HAPRECI
(Harnessing Plant Reproduction for Crop Improvement). E.B. and C.C. were supported
by the European Research Council through a ‘Starting Independent Research’ grant
(ERC-2007-Stg-207362-HCPO). We thank A.P. MacCabe (Consejo Superior de Investigaciones
Científicas, Valencia, Spain) for critical reading of the manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Francesca
full_name: Galbiati, Francesca
last_name: Galbiati
- first_name: Dola
full_name: Sinha Roy, Dola
last_name: Sinha Roy
- first_name: Sara
full_name: Simonini, Sara
last_name: Simonini
- first_name: Mara
full_name: Cucinotta, Mara
last_name: Cucinotta
- first_name: Luca
full_name: Ceccato, Luca
last_name: Ceccato
- first_name: Candela
full_name: Cuesta, Candela
id: 33A3C818-F248-11E8-B48F-1D18A9856A87
last_name: Cuesta
orcid: 0000-0003-1923-2410
- first_name: Mária
full_name: Šimášková, Mária
last_name: Šimášková
- first_name: Eva
full_name: Benková, Eva
id: 38F4F166-F248-11E8-B48F-1D18A9856A87
last_name: Benková
orcid: 0000-0002-8510-9739
- first_name: Yuri
full_name: Kamiuchi, Yuri
last_name: Kamiuchi
- first_name: Mitsuhiro
full_name: Aida, Mitsuhiro
last_name: Aida
- first_name: Dolf
full_name: Weijers, Dolf
last_name: Weijers
- first_name: Rüdiger
full_name: Simon, Rüdiger
last_name: Simon
- first_name: Simona
full_name: Masiero, Simona
last_name: Masiero
- first_name: Lucia
full_name: Colombo, Lucia
last_name: Colombo
citation:
ama: Galbiati F, Sinha Roy D, Simonini S, et al. An integrative model of the control
of ovule primordia formation. The Plant journal for cell and molecular biology.
2013;76(3):446-455. doi:10.1111/tpj.12309
apa: Galbiati, F., Sinha Roy, D., Simonini, S., Cucinotta, M., Ceccato, L., Cuesta,
C., … Colombo, L. (2013). An integrative model of the control of ovule primordia
formation. The Plant Journal for Cell and Molecular Biology. Wiley-Blackwell.
https://doi.org/10.1111/tpj.12309
chicago: Galbiati, Francesca, Dola Sinha Roy, Sara Simonini, Mara Cucinotta, Luca
Ceccato, Candela Cuesta, Mária Šimášková, et al. “An Integrative Model of the
Control of Ovule Primordia Formation.” The Plant Journal for Cell and Molecular
Biology. Wiley-Blackwell, 2013. https://doi.org/10.1111/tpj.12309.
ieee: F. Galbiati et al., “An integrative model of the control of ovule primordia
formation,” The Plant journal for cell and molecular biology, vol. 76,
no. 3. Wiley-Blackwell, pp. 446–455, 2013.
ista: Galbiati F, Sinha Roy D, Simonini S, Cucinotta M, Ceccato L, Cuesta C, Šimášková
M, Benková E, Kamiuchi Y, Aida M, Weijers D, Simon R, Masiero S, Colombo L. 2013.
An integrative model of the control of ovule primordia formation. The Plant journal
for cell and molecular biology. 76(3), 446–455.
mla: Galbiati, Francesca, et al. “An Integrative Model of the Control of Ovule Primordia
Formation.” The Plant Journal for Cell and Molecular Biology, vol. 76,
no. 3, Wiley-Blackwell, 2013, pp. 446–55, doi:10.1111/tpj.12309.
short: F. Galbiati, D. Sinha Roy, S. Simonini, M. Cucinotta, L. Ceccato, C. Cuesta,
M. Šimášková, E. Benková, Y. Kamiuchi, M. Aida, D. Weijers, R. Simon, S. Masiero,
L. Colombo, The Plant Journal for Cell and Molecular Biology 76 (2013) 446–455.
date_created: 2018-12-11T11:48:44Z
date_published: 2013-09-19T00:00:00Z
date_updated: 2022-03-21T07:17:26Z
day: '19'
doi: 10.1111/tpj.12309
extern: '1'
external_id:
pmid:
- '23941199'
intvolume: ' 76'
issue: '3'
language:
- iso: eng
month: '09'
oa_version: None
page: 446 - 455
pmid: 1
publication: The Plant journal for cell and molecular biology
publication_status: published
publisher: Wiley-Blackwell
publist_id: '6818'
quality_controlled: '1'
scopus_import: '1'
status: public
title: An integrative model of the control of ovule primordia formation
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 76
year: '2013'
...
---
_id: '831'
abstract:
- lang: eng
text: In Arabidopsis, lateral roots originate from pericycle cells deep within the
primary root. New lateral root primordia (LRP) have to emerge through several
overlaying tissues. Here, we report that auxin produced in new LRP is transported
towards the outer tissues where it triggers cell separation by inducing both the
auxin influx carrier LAX3 and cell-wall enzymes. LAX3 is expressed in just two
cell files overlaying new LRP. To understand how this striking pattern of LAX3
expression is regulated, we developed a mathematical model that captures the network
regulating its expression and auxin transport within realistic three-dimensional
cell and tissue geometries. Our model revealed that, for the LAX3 spatial expression
to be robust to natural variations in root tissue geometry, an efflux carrier
is required--later identified to be PIN3. To prevent LAX3 from being transiently
expressed in multiple cell files, PIN3 and LAX3 must be induced consecutively,
which we later demonstrated to be the case. Our study exemplifies how mathematical
models can be used to direct experiments to elucidate complex developmental processes.
acknowledgement: This work was supported by an FEBS Long‐Term Fellowship (BP), an
Intra‐European Fellowship for Career Development under the 7th framework of the
European Commission (IEF‐2008‐220506 to BP), an EMBO Long‐Term Fellowship (BP),
an European Reintegration Grant under the 7th framework of the European Commission
(ERG‐2010‐276662 to BP) and the Swedish Research Council (VR 621‐2010‐5720 to IS,
GS and KL). AMM, APF, AL, LRB, SP, NM, DMW, MO, JRK and MJB acknowledge the support
of the Biotechnology and Biological Sciences Research Council (BBSRC) and Engineering
and Physical Sciences Research Council (EPSRC) funding to the Centre for Plant Integrative
Biology (CPIB); BBSRC Professorial Research Fellowship funding to DMW and MJB; Belgian
Scientific policy (BELSPO contract MARS) to TB and MJB. We thank Bert de Rybel for
his help in Multisite Gateway cloning.
author:
- first_name: Benjamin
full_name: Péret, Benjamin
last_name: Péret
- first_name: Alistair
full_name: Middleton, Alistair M
last_name: Middleton
- first_name: Andrew
full_name: French, Andrew P
last_name: French
- first_name: Antoine
full_name: Larrieu, Antoine
last_name: Larrieu
- first_name: Anthony
full_name: Bishopp, Anthony
last_name: Bishopp
- first_name: Maria
full_name: Njo, Maria
last_name: Njo
- first_name: Darren
full_name: Wells, Darren M
last_name: Wells
- first_name: Silvana
full_name: Porco, Silvana
last_name: Porco
- first_name: Nathan
full_name: Mellor, Nathan
last_name: Mellor
- first_name: Leah
full_name: Band, Leah R
last_name: Band
- first_name: Ilda
full_name: Casimiro, Ilda
last_name: Casimiro
- first_name: Jürgen
full_name: Kleine-Vehn, Jürgen
last_name: Kleine Vehn
- first_name: Steffen
full_name: Vanneste, Steffen
last_name: Vanneste
- first_name: Ilkka
full_name: Sairanen, Ilkka
last_name: Sairanen
- first_name: Romain
full_name: Mallet, Romain
last_name: Mallet
- first_name: Göran
full_name: Sandberg, Göran
last_name: Sandberg
- first_name: Karin
full_name: Ljung, Karin
last_name: Ljung
- first_name: Tom
full_name: Beeckman, Tom
last_name: Beeckman
- first_name: Eva
full_name: Eva Benková
id: 38F4F166-F248-11E8-B48F-1D18A9856A87
last_name: Benková
orcid: 0000-0002-8510-9739
- first_name: Jirí
full_name: Jirí Friml
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Eric
full_name: Kramer, Eric
last_name: Kramer
- first_name: John
full_name: King, John R
last_name: King
- first_name: Ive
full_name: De Smet, Ive
last_name: De Smet
- first_name: Tony
full_name: Pridmore, Tony
last_name: Pridmore
- first_name: Markus
full_name: Owen, Markus
last_name: Owen
- first_name: Malcolm
full_name: Bennett, Malcolm J
last_name: Bennett
citation:
ama: Péret B, Middleton A, French A, et al. Sequential induction of auxin efflux
and influx carriers regulates lateral root emergence. Molecular Systems Biology.
2013;9. doi:10.1038/msb.2013.43
apa: Péret, B., Middleton, A., French, A., Larrieu, A., Bishopp, A., Njo, M., …
Bennett, M. (2013). Sequential induction of auxin efflux and influx carriers regulates
lateral root emergence. Molecular Systems Biology. Nature Publishing Group.
https://doi.org/10.1038/msb.2013.43
chicago: Péret, Benjamin, Alistair Middleton, Andrew French, Antoine Larrieu, Anthony
Bishopp, Maria Njo, Darren Wells, et al. “Sequential Induction of Auxin Efflux
and Influx Carriers Regulates Lateral Root Emergence.” Molecular Systems Biology.
Nature Publishing Group, 2013. https://doi.org/10.1038/msb.2013.43.
ieee: B. Péret et al., “Sequential induction of auxin efflux and influx carriers
regulates lateral root emergence,” Molecular Systems Biology, vol. 9. Nature
Publishing Group, 2013.
ista: Péret B, Middleton A, French A, Larrieu A, Bishopp A, Njo M, Wells D, Porco
S, Mellor N, Band L, Casimiro I, Kleine Vehn J, Vanneste S, Sairanen I, Mallet
R, Sandberg G, Ljung K, Beeckman T, Benková E, Friml J, Kramer E, King J, De Smet
I, Pridmore T, Owen M, Bennett M. 2013. Sequential induction of auxin efflux and
influx carriers regulates lateral root emergence. Molecular Systems Biology. 9.
mla: Péret, Benjamin, et al. “Sequential Induction of Auxin Efflux and Influx Carriers
Regulates Lateral Root Emergence.” Molecular Systems Biology, vol. 9, Nature
Publishing Group, 2013, doi:10.1038/msb.2013.43.
short: B. Péret, A. Middleton, A. French, A. Larrieu, A. Bishopp, M. Njo, D. Wells,
S. Porco, N. Mellor, L. Band, I. Casimiro, J. Kleine Vehn, S. Vanneste, I. Sairanen,
R. Mallet, G. Sandberg, K. Ljung, T. Beeckman, E. Benková, J. Friml, E. Kramer,
J. King, I. De Smet, T. Pridmore, M. Owen, M. Bennett, Molecular Systems Biology
9 (2013).
date_created: 2018-12-11T11:48:44Z
date_published: 2013-10-22T00:00:00Z
date_updated: 2021-01-12T08:18:03Z
day: '22'
doi: 10.1038/msb.2013.43
extern: 1
intvolume: ' 9'
month: '10'
publication: Molecular Systems Biology
publication_status: published
publisher: Nature Publishing Group
publist_id: '6817'
quality_controlled: 0
status: public
title: Sequential induction of auxin efflux and influx carriers regulates lateral
root emergence
tmp:
image: /images/cc_by_nc_sa.png
legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
BY-NC-SA 4.0)
short: CC BY-NC-SA (4.0)
type: journal_article
volume: 9
year: '2013'
...
---
_id: '8461'
abstract:
- lang: eng
text: Solid-state NMR provides insight into protein motion over time scales ranging
from picoseconds to seconds. While in solution state the methodology to measure
protein dynamics is well established, there is currently no such consensus protocol
for measuring dynamics in solids. In this article, we perform a detailed investigation
of measurement protocols for fast motions, i.e. motions ranging from picoseconds
to a few microseconds, which is the range covered by dipolar coupling and relaxation
experiments. We perform a detailed theoretical investigation how dipolar couplings
and relaxation data can provide information about amplitudes and time scales of
local motion. We show that the measurement of dipolar couplings is crucial for
obtaining accurate motional parameters, while systematic errors are found when
only relaxation data are used. Based on this realization, we investigate how the
REDOR experiment can provide such data in a very accurate manner. We identify
that with accurate rf calibration, and explicit consideration of rf field inhomogeneities,
one can obtain highly accurate absolute order parameters. We then perform joint
model-free analyses of 6 relaxation data sets and dipolar couplings, based on
previously existing, as well as new data sets on microcrystalline ubiquitin. We
show that nanosecond motion can be detected primarily in loop regions, and compare
solid-state data to solution-state relaxation and RDC analyses. The protocols
investigated here will serve as a useful basis towards the establishment of a
routine protocol for the characterization of ps–μs motions in proteins by solid-state
NMR.
article_processing_charge: No
article_type: original
author:
- first_name: Jens D.
full_name: Haller, Jens D.
last_name: Haller
- first_name: Paul
full_name: Schanda, Paul
id: 7B541462-FAF6-11E9-A490-E8DFE5697425
last_name: Schanda
orcid: 0000-0002-9350-7606
citation:
ama: 'Haller JD, Schanda P. Amplitudes and time scales of picosecond-to-microsecond
motion in proteins studied by solid-state NMR: a critical evaluation of experimental
approaches and application to crystalline ubiquitin. Journal of Biomolecular
NMR. 2013;57(3):263-280. doi:10.1007/s10858-013-9787-x'
apa: 'Haller, J. D., & Schanda, P. (2013). Amplitudes and time scales of picosecond-to-microsecond
motion in proteins studied by solid-state NMR: a critical evaluation of experimental
approaches and application to crystalline ubiquitin. Journal of Biomolecular
NMR. Springer Nature. https://doi.org/10.1007/s10858-013-9787-x'
chicago: 'Haller, Jens D., and Paul Schanda. “Amplitudes and Time Scales of Picosecond-to-Microsecond
Motion in Proteins Studied by Solid-State NMR: A Critical Evaluation of Experimental
Approaches and Application to Crystalline Ubiquitin.” Journal of Biomolecular
NMR. Springer Nature, 2013. https://doi.org/10.1007/s10858-013-9787-x.'
ieee: 'J. D. Haller and P. Schanda, “Amplitudes and time scales of picosecond-to-microsecond
motion in proteins studied by solid-state NMR: a critical evaluation of experimental
approaches and application to crystalline ubiquitin,” Journal of Biomolecular
NMR, vol. 57, no. 3. Springer Nature, pp. 263–280, 2013.'
ista: 'Haller JD, Schanda P. 2013. Amplitudes and time scales of picosecond-to-microsecond
motion in proteins studied by solid-state NMR: a critical evaluation of experimental
approaches and application to crystalline ubiquitin. Journal of Biomolecular NMR.
57(3), 263–280.'
mla: 'Haller, Jens D., and Paul Schanda. “Amplitudes and Time Scales of Picosecond-to-Microsecond
Motion in Proteins Studied by Solid-State NMR: A Critical Evaluation of Experimental
Approaches and Application to Crystalline Ubiquitin.” Journal of Biomolecular
NMR, vol. 57, no. 3, Springer Nature, 2013, pp. 263–80, doi:10.1007/s10858-013-9787-x.'
short: J.D. Haller, P. Schanda, Journal of Biomolecular NMR 57 (2013) 263–280.
date_created: 2020-09-18T10:09:05Z
date_published: 2013-10-09T00:00:00Z
date_updated: 2021-01-12T08:19:26Z
day: '09'
doi: 10.1007/s10858-013-9787-x
extern: '1'
intvolume: ' 57'
issue: '3'
keyword:
- Spectroscopy
- Biochemistry
language:
- iso: eng
month: '10'
oa_version: None
page: 263-280
publication: Journal of Biomolecular NMR
publication_identifier:
issn:
- 0925-2738
- 1573-5001
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: 'Amplitudes and time scales of picosecond-to-microsecond motion in proteins
studied by solid-state NMR: a critical evaluation of experimental approaches and
application to crystalline ubiquitin'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 57
year: '2013'
...
---
_id: '8462'
abstract:
- lang: eng
text: The transition of proteins from their soluble functional state to amyloid
fibrils and aggregates is associated with the onset of several human diseases.
Protein aggregation often requires some structural reshaping and the subsequent
formation of intermolecular contacts. Therefore, the study of the conformation
of excited protein states and their ability to form oligomers is of primary importance
for understanding the molecular basis of amyloid fibril formation. Here, we investigated
the oligomerization processes that occur along the folding of the amyloidogenic
human protein β2-microglobulin. The combination of real-time two-dimensional NMR
data with real-time small-angle X-ray scattering measurements allowed us to derive
thermodynamic and kinetic information on protein oligomerization of different
conformational states populated along the folding pathways. In particular, we
could demonstrate that a long-lived folding intermediate (I-state) has a higher
propensity to oligomerize compared to the native state. Our data agree well with
a simple five-state kinetic model that involves only monomeric and dimeric species.
The dimers have an elongated shape with the dimerization interface located at
the apical side of β2-microglobulin close to Pro32, the residue that has a trans
conformation in the I-state and a cis conformation in the native (N) state. Our
experimental data suggest that partial unfolding in the apical half of the protein
close to Pro32 leads to an excited state conformation with enhanced propensity
for oligomerization. This excited state becomes more populated in the transient
I-state due to the destabilization of the native conformation by the trans-Pro32
configuration.
article_processing_charge: No
article_type: original
author:
- first_name: E.
full_name: Rennella, E.
last_name: Rennella
- first_name: T.
full_name: Cutuil, T.
last_name: Cutuil
- first_name: Paul
full_name: Schanda, Paul
id: 7B541462-FAF6-11E9-A490-E8DFE5697425
last_name: Schanda
orcid: 0000-0002-9350-7606
- first_name: I.
full_name: Ayala, I.
last_name: Ayala
- first_name: F.
full_name: Gabel, F.
last_name: Gabel
- first_name: V.
full_name: Forge, V.
last_name: Forge
- first_name: A.
full_name: Corazza, A.
last_name: Corazza
- first_name: G.
full_name: Esposito, G.
last_name: Esposito
- first_name: B.
full_name: Brutscher, B.
last_name: Brutscher
citation:
ama: 'Rennella E, Cutuil T, Schanda P, et al. Oligomeric states along the folding
pathways of β2-microglobulin: Kinetics, thermodynamics, and structure. Journal
of Molecular Biology. 2013;425(15):2722-2736. doi:10.1016/j.jmb.2013.04.028'
apa: 'Rennella, E., Cutuil, T., Schanda, P., Ayala, I., Gabel, F., Forge, V., …
Brutscher, B. (2013). Oligomeric states along the folding pathways of β2-microglobulin:
Kinetics, thermodynamics, and structure. Journal of Molecular Biology.
Elsevier. https://doi.org/10.1016/j.jmb.2013.04.028'
chicago: 'Rennella, E., T. Cutuil, Paul Schanda, I. Ayala, F. Gabel, V. Forge, A.
Corazza, G. Esposito, and B. Brutscher. “Oligomeric States along the Folding Pathways
of Β2-Microglobulin: Kinetics, Thermodynamics, and Structure.” Journal of Molecular
Biology. Elsevier, 2013. https://doi.org/10.1016/j.jmb.2013.04.028.'
ieee: 'E. Rennella et al., “Oligomeric states along the folding pathways
of β2-microglobulin: Kinetics, thermodynamics, and structure,” Journal of Molecular
Biology, vol. 425, no. 15. Elsevier, pp. 2722–2736, 2013.'
ista: 'Rennella E, Cutuil T, Schanda P, Ayala I, Gabel F, Forge V, Corazza A, Esposito
G, Brutscher B. 2013. Oligomeric states along the folding pathways of β2-microglobulin:
Kinetics, thermodynamics, and structure. Journal of Molecular Biology. 425(15),
2722–2736.'
mla: 'Rennella, E., et al. “Oligomeric States along the Folding Pathways of Β2-Microglobulin:
Kinetics, Thermodynamics, and Structure.” Journal of Molecular Biology,
vol. 425, no. 15, Elsevier, 2013, pp. 2722–36, doi:10.1016/j.jmb.2013.04.028.'
short: E. Rennella, T. Cutuil, P. Schanda, I. Ayala, F. Gabel, V. Forge, A. Corazza,
G. Esposito, B. Brutscher, Journal of Molecular Biology 425 (2013) 2722–2736.
date_created: 2020-09-18T10:09:12Z
date_published: 2013-08-09T00:00:00Z
date_updated: 2022-08-25T14:56:24Z
day: '09'
doi: 10.1016/j.jmb.2013.04.028
extern: '1'
intvolume: ' 425'
issue: '15'
keyword:
- Molecular Biology
language:
- iso: eng
month: '08'
oa_version: None
page: 2722-2736
publication: Journal of Molecular Biology
publication_identifier:
issn:
- 0022-2836
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: 'Oligomeric states along the folding pathways of β2-microglobulin: Kinetics,
thermodynamics, and structure'
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 425
year: '2013'
...
---
_id: '894'
abstract:
- lang: eng
text: 'Background: Genetic variation at the melanocortin-1 receptor (MC1R) gene
is correlated with melanin color variation in many birds. Feral pigeons (Columba
livia) show two major melanin-based colorations: a red coloration due to pheomelanic
pigment and a black coloration due to eumelanic pigment. Furthermore, within each
color type, feral pigeons display continuous variation in the amount of melanin
pigment present in the feathers, with individuals varying from pure white to a
full dark melanic color. Coloration is highly heritable and it has been suggested
that it is under natural or sexual selection, or both. Our objective was to investigate
whether MC1R allelic variants are associated with plumage color in feral pigeons.
Findings. We sequenced 888 bp of the coding sequence of MC1R among pigeons varying
both in the type, eumelanin or pheomelanin, and the amount of melanin in their
feathers. We detected 10 non-synonymous substitutions and 2 synonymous substitution
but none of them were associated with a plumage type. It remains possible that
non-synonymous substitutions that influence coloration are present in the short
MC1R fragment that we did not sequence but this seems unlikely because we analyzed
the entire functionally important region of the gene. Conclusions: Our results
show that color differences among feral pigeons are probably not attributable
to amino acid variation at the MC1R locus. Therefore, variation in regulatory
regions of MC1R or variation in other genes may be responsible for the color polymorphism
of feral pigeons.'
acknowledgement: Romain Derelle was supported by grant from Plan Nacional 004302 BFU2012-31329.
Fyodor A Kondrashov was supported by grants HHMI (Howard Hughes Medical Institute)
003803 and EMBO 003691 EUI-EURYIP-2011-4320.
author:
- first_name: Romain
full_name: Derelle, Romain
last_name: Derelle
- first_name: Fyodor
full_name: Kondrashov, Fyodor
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
- first_name: Vladimir
full_name: Arkhipov, Vladimir
last_name: Arkhipov
- first_name: Hélène
full_name: Corbel, Hélène
last_name: Corbel
- first_name: Adrien
full_name: Frantz, Adrien
last_name: Frantz
- first_name: Julien
full_name: Gasparini, Julien
last_name: Gasparini
- first_name: Lisa
full_name: Jacquin, Lisa
last_name: Jacquin
- first_name: Gwenaël
full_name: Jacob, Gwenaël
last_name: Jacob
- first_name: Sophie
full_name: Thibault, Sophie
last_name: Thibault
- first_name: Emmanuelle
full_name: Baudry, Emmanuelle
last_name: Baudry
citation:
ama: Derelle R, Kondrashov F, Arkhipov V, et al. Color differences among feral pigeons
(Columba livia) are not attributable to sequence variation in the coding region
of the melanocortin-1 receptor gene MC1R. BMC Research Notes. 2013;6(1).
doi:10.1186/1756-0500-6-310
apa: Derelle, R., Kondrashov, F., Arkhipov, V., Corbel, H., Frantz, A., Gasparini,
J., … Baudry, E. (2013). Color differences among feral pigeons (Columba livia)
are not attributable to sequence variation in the coding region of the melanocortin-1
receptor gene MC1R. BMC Research Notes. BioMed Central. https://doi.org/10.1186/1756-0500-6-310
chicago: Derelle, Romain, Fyodor Kondrashov, Vladimir Arkhipov, Hélène Corbel, Adrien
Frantz, Julien Gasparini, Lisa Jacquin, Gwenaël Jacob, Sophie Thibault, and Emmanuelle
Baudry. “Color Differences among Feral Pigeons (Columba Livia) Are Not Attributable
to Sequence Variation in the Coding Region of the Melanocortin-1 Receptor Gene
MC1R.” BMC Research Notes. BioMed Central, 2013. https://doi.org/10.1186/1756-0500-6-310.
ieee: R. Derelle et al., “Color differences among feral pigeons (Columba
livia) are not attributable to sequence variation in the coding region of the
melanocortin-1 receptor gene MC1R,” BMC Research Notes, vol. 6, no. 1.
BioMed Central, 2013.
ista: Derelle R, Kondrashov F, Arkhipov V, Corbel H, Frantz A, Gasparini J, Jacquin
L, Jacob G, Thibault S, Baudry E. 2013. Color differences among feral pigeons
(Columba livia) are not attributable to sequence variation in the coding region
of the melanocortin-1 receptor gene MC1R. BMC Research Notes. 6(1).
mla: Derelle, Romain, et al. “Color Differences among Feral Pigeons (Columba Livia)
Are Not Attributable to Sequence Variation in the Coding Region of the Melanocortin-1
Receptor Gene MC1R.” BMC Research Notes, vol. 6, no. 1, BioMed Central,
2013, doi:10.1186/1756-0500-6-310.
short: R. Derelle, F. Kondrashov, V. Arkhipov, H. Corbel, A. Frantz, J. Gasparini,
L. Jacquin, G. Jacob, S. Thibault, E. Baudry, BMC Research Notes 6 (2013).
date_created: 2018-12-11T11:49:04Z
date_published: 2013-01-01T00:00:00Z
date_updated: 2021-01-12T08:21:25Z
day: '01'
doi: 10.1186/1756-0500-6-310
extern: '1'
intvolume: ' 6'
issue: '1'
language:
- iso: eng
month: '01'
oa_version: None
publication: BMC Research Notes
publication_status: published
publisher: BioMed Central
publist_id: '6752'
status: public
title: Color differences among feral pigeons (Columba livia) are not attributable
to sequence variation in the coding region of the melanocortin-1 receptor gene MC1R
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 6
year: '2013'
...