---
_id: '3697'
abstract:
- lang: eng
  text: The goal of this paper is to evaluate and compare models and methods for learning
    to recognize basic entities in images in an unsupervised setting. In other words,
    we want to discover the objects present in the images by analyzing unlabeled data
    and searching for re-occurring patterns. We experiment with various baseline methods,
    methods based on latent variable models, as well as spectral clustering methods.
    The results are presented and compared both on subsets of Caltech256 and MSRC2,
    data sets that are larger and more challenging and that include more object classes
    than what has previously been reported in the literature. A rigorous framework
    for evaluating unsupervised object discovery methods is proposed.
acknowledgement: The authors acknowledge support from the EU projects CLASS (IST project
  027978), PerAct (IST project 504321) and the EU Network of Excellence PASCAL2.
author:
- first_name: Tinne
  full_name: Tuytelaars,Tinne
  last_name: Tuytelaars
- first_name: Christoph
  full_name: Christoph Lampert
  id: 40C20FD2-F248-11E8-B48F-1D18A9856A87
  last_name: Lampert
  orcid: 0000-0001-8622-7887
- first_name: Matthew
  full_name: Blaschko,Matthew B
  last_name: Blaschko
- first_name: Wray
  full_name: Buntine,Wray
  last_name: Buntine
citation:
  ama: 'Tuytelaars T, Lampert C, Blaschko M, Buntine W. Unsupervised object discovery:
    A comparison. <i>International Journal of Computer Vision</i>. 2010;88(2):284-302.
    doi:<a href="https://doi.org/10.1007/s11263-009-0271-8">10.1007/s11263-009-0271-8</a>'
  apa: 'Tuytelaars, T., Lampert, C., Blaschko, M., &#38; Buntine, W. (2010). Unsupervised
    object discovery: A comparison. <i>International Journal of Computer Vision</i>.
    Springer. <a href="https://doi.org/10.1007/s11263-009-0271-8">https://doi.org/10.1007/s11263-009-0271-8</a>'
  chicago: 'Tuytelaars, Tinne, Christoph Lampert, Matthew Blaschko, and Wray Buntine.
    “Unsupervised Object Discovery: A Comparison.” <i>International Journal of Computer
    Vision</i>. Springer, 2010. <a href="https://doi.org/10.1007/s11263-009-0271-8">https://doi.org/10.1007/s11263-009-0271-8</a>.'
  ieee: 'T. Tuytelaars, C. Lampert, M. Blaschko, and W. Buntine, “Unsupervised object
    discovery: A comparison,” <i>International Journal of Computer Vision</i>, vol.
    88, no. 2. Springer, pp. 284–302, 2010.'
  ista: 'Tuytelaars T, Lampert C, Blaschko M, Buntine W. 2010. Unsupervised object
    discovery: A comparison. International Journal of Computer Vision. 88(2), 284–302.'
  mla: 'Tuytelaars, Tinne, et al. “Unsupervised Object Discovery: A Comparison.” <i>International
    Journal of Computer Vision</i>, vol. 88, no. 2, Springer, 2010, pp. 284–302, doi:<a
    href="https://doi.org/10.1007/s11263-009-0271-8">10.1007/s11263-009-0271-8</a>.'
  short: T. Tuytelaars, C. Lampert, M. Blaschko, W. Buntine, International Journal
    of Computer Vision 88 (2010) 284–302.
date_created: 2018-12-11T12:04:40Z
date_published: 2010-06-01T00:00:00Z
date_updated: 2021-01-12T07:49:02Z
day: '01'
doi: 10.1007/s11263-009-0271-8
extern: 1
intvolume: '        88'
issue: '2'
month: '06'
page: 284 - 302
publication: International Journal of Computer Vision
publication_status: published
publisher: Springer
publist_id: '2664'
quality_controlled: 0
status: public
title: 'Unsupervised object discovery: A comparison'
tmp:
  image: /images/cc_by_nc.png
  legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
  short: CC BY-NC (4.0)
type: journal_article
volume: 88
year: '2010'
...
---
_id: '3702'
abstract:
- lang: eng
  text: Hitting and batting tasks, such as tennis forehands, ping-pong strokes, or
    baseball batting, depend on predictions where the ball can be intercepted and
    how it can properly be returned to the opponent. These predictions get more accurate
    over time, hence the behaviors need to be continuously modified. As a result,
    movement templates with a learned global shape need to be adapted during the execution
    so that the racket reaches a target position and velocity that will return the
    ball over to the other side of the net or court. It requires altering learned
    movements to hit a varying target with the necessary velocity at a specific instant
    in time. Such a task cannot be incorporated straightforwardly in most movement
    representations suitable for learning. For example, the standard formulation of
    the dynamical system based motor primitives (introduced by Ijspeert et al. [1])
    does not satisfy this property despite their flexibility which has allowed learning
    tasks ranging from locomotion to kendama. In order to fulfill this requirement,
    we reformulate the Ijspeert framework to incorporate the possibility of specifying
    a desired hitting point and a desired hitting velocity while maintaining all advantages
    of the original formulation. We show that the proposed movement template formulation
    works well in two scenarios, i.e., for hitting a ball on a string with a table
    tennis racket at a specified velocity and for returning balls launched by a ball
    gun successfully over the net using forehand movements. All experiments were carried
    out on a Barrett WAM using a four camera vision system.
author:
- first_name: Jens
  full_name: Kober,Jens
  last_name: Kober
- first_name: Katharina
  full_name: Mülling,Katharina
  last_name: Mülling
- first_name: Oliver
  full_name: Krömer,Oliver
  last_name: Krömer
- first_name: Christoph
  full_name: Christoph Lampert
  id: 40C20FD2-F248-11E8-B48F-1D18A9856A87
  last_name: Lampert
  orcid: 0000-0001-8622-7887
- first_name: Bernhard
  full_name: Schölkopf,Bernhard
  last_name: Schölkopf
- first_name: Jan
  full_name: Peters, Jan
  last_name: Peters
citation:
  ama: 'Kober J, Mülling K, Krömer O, Lampert C, Schölkopf B, Peters J. Movement templates
    for learning of hitting and batting. In: IEEE; 2010:853-858. doi:<a href="https://doi.org/10.1109/ROBOT.2010.5509672">10.1109/ROBOT.2010.5509672</a>'
  apa: 'Kober, J., Mülling, K., Krömer, O., Lampert, C., Schölkopf, B., &#38; Peters,
    J. (2010). Movement templates for learning of hitting and batting (pp. 853–858).
    Presented at the ICRA: International Conference on Robotics and Automation, IEEE.
    <a href="https://doi.org/10.1109/ROBOT.2010.5509672">https://doi.org/10.1109/ROBOT.2010.5509672</a>'
  chicago: Kober, Jens, Katharina Mülling, Oliver Krömer, Christoph Lampert, Bernhard
    Schölkopf, and Jan Peters. “Movement Templates for Learning of Hitting and Batting,”
    853–58. IEEE, 2010. <a href="https://doi.org/10.1109/ROBOT.2010.5509672">https://doi.org/10.1109/ROBOT.2010.5509672</a>.
  ieee: 'J. Kober, K. Mülling, O. Krömer, C. Lampert, B. Schölkopf, and J. Peters,
    “Movement templates for learning of hitting and batting,” presented at the ICRA:
    International Conference on Robotics and Automation, 2010, pp. 853–858.'
  ista: 'Kober J, Mülling K, Krömer O, Lampert C, Schölkopf B, Peters J. 2010. Movement
    templates for learning of hitting and batting. ICRA: International Conference
    on Robotics and Automation, 853–858.'
  mla: Kober, Jens, et al. <i>Movement Templates for Learning of Hitting and Batting</i>.
    IEEE, 2010, pp. 853–58, doi:<a href="https://doi.org/10.1109/ROBOT.2010.5509672">10.1109/ROBOT.2010.5509672</a>.
  short: J. Kober, K. Mülling, O. Krömer, C. Lampert, B. Schölkopf, J. Peters, in:,
    IEEE, 2010, pp. 853–858.
conference:
  name: 'ICRA: International Conference on Robotics and Automation'
date_created: 2018-12-11T12:04:42Z
date_published: 2010-05-07T00:00:00Z
date_updated: 2021-01-12T07:51:35Z
day: '07'
doi: 10.1109/ROBOT.2010.5509672
extern: 1
main_file_link:
- open_access: '0'
  url: http://www.kyb.mpg.de/fileadmin/user_upload/files/publications/attachments/ICRA2010-Kober_6231%5b1%5d.pdf
month: '05'
page: 853 - 858
publication_status: published
publisher: IEEE
publist_id: '2654'
quality_controlled: 0
status: public
title: Movement templates for learning of hitting and batting
type: conference
year: '2010'
...
---
_id: '3713'
abstract:
- lang: eng
  text: We introduce a method to accelerate the evaluation of object detection cascades
    with the help of a divide-and-conquer procedure in the space of candidate regions.
    Compared to the exhaustive procedure that thus far is the state-of-the-art for
    cascade evaluation, the proposed method requires fewer evaluations of the classifier
    functions, thereby speeding up the search. Furthermore, we show how the recently
    developed efficient subwindow search (ESS) procedure [11] can be integrated into
    the last stage of our method. This allows us to use our method to act not only
    as a faster procedure for cascade evaluation, but also as a tool to perform efficient
    branch-and-bound object detection with nonlinear quality functions, in particular
    kernelized support vector machines. Experiments on the PASCAL VOC 2006 dataset
    show an acceleration of more than 50% by our method compared to standard cascade
    evaluation.
acknowledgement: |-
  Conference Information URL:

  http://cvl.umiacs.umd.edu/conferences/cvpr2010/
author:
- first_name: Christoph
  full_name: Christoph Lampert
  id: 40C20FD2-F248-11E8-B48F-1D18A9856A87
  last_name: Lampert
  orcid: 0000-0001-8622-7887
citation:
  ama: 'Lampert C. An efficient divide-and-conquer cascade for nonlinear object detection.
    In: IEEE; 2010:1022-1029. doi:<a href="https://doi.org/10.1109/CVPR.2010.5540107">10.1109/CVPR.2010.5540107</a>'
  apa: 'Lampert, C. (2010). An efficient divide-and-conquer cascade for nonlinear
    object detection (pp. 1022–1029). Presented at the CVPR: Computer Vision and Pattern
    Recognition, IEEE. <a href="https://doi.org/10.1109/CVPR.2010.5540107">https://doi.org/10.1109/CVPR.2010.5540107</a>'
  chicago: Lampert, Christoph. “An Efficient Divide-and-Conquer Cascade for Nonlinear
    Object Detection,” 1022–29. IEEE, 2010. <a href="https://doi.org/10.1109/CVPR.2010.5540107">https://doi.org/10.1109/CVPR.2010.5540107</a>.
  ieee: 'C. Lampert, “An efficient divide-and-conquer cascade for nonlinear object
    detection,” presented at the CVPR: Computer Vision and Pattern Recognition, 2010,
    pp. 1022–1029.'
  ista: 'Lampert C. 2010. An efficient divide-and-conquer cascade for nonlinear object
    detection. CVPR: Computer Vision and Pattern Recognition, 1022–1029.'
  mla: Lampert, Christoph. <i>An Efficient Divide-and-Conquer Cascade for Nonlinear
    Object Detection</i>. IEEE, 2010, pp. 1022–29, doi:<a href="https://doi.org/10.1109/CVPR.2010.5540107">10.1109/CVPR.2010.5540107</a>.
  short: C. Lampert, in:, IEEE, 2010, pp. 1022–1029.
conference:
  name: 'CVPR: Computer Vision and Pattern Recognition'
date_created: 2018-12-11T12:04:46Z
date_published: 2010-06-18T00:00:00Z
date_updated: 2021-01-12T07:51:40Z
day: '18'
doi: 10.1109/CVPR.2010.5540107
extern: 1
month: '06'
page: 1022 - 1029
publication_status: published
publisher: IEEE
publist_id: '2643'
quality_controlled: 0
status: public
title: An efficient divide-and-conquer cascade for nonlinear object detection
type: conference
year: '2010'
...
---
_id: '3718'
abstract:
- lang: eng
  text: Long-term depression (LTD) is a form of synaptic plasticity that may contribute
    to information storage in the central nervous system. Here we report that LTD
    can be elicited in layer 5 pyramidal neurons of the rat prefrontal cortex by pairing
    low frequency stimulation with a modest postsynaptic depolarization. The induction
    of LTD required the activation of both metabotropic glutamate receptors of the
    mGlu1 subtype and voltage-sensitive Ca(2+) channels (VSCCs) of the T/R, P/Q and
    N types, leading to the stimulation of intracellular inositol trisphosphate (IP3)
    receptors by IP3 and Ca(2+). The subsequent release of Ca(2+) from intracellular
    stores activated the protein phosphatase cascade involving calcineurin and protein
    phosphatase 1. The activation of purinergic P2Y(1) receptors blocked LTD. This
    effect was prevented by P2Y(1) receptor antagonists and was absent in mice lacking
    P2Y(1) but not P2Y(2) receptors. We also found that activation of P2Y(1) receptors
    inhibits Ca(2+) transients via VSCCs in the apical dendrites and spines of pyramidal
    neurons. In addition, we show that the release of ATP under hypoxia is able to
    inhibit LTD by acting on postsynaptic P2Y(1) receptors. In conclusion, these data
    suggest that the reduction of Ca(2+) influx via VSCCs caused by the activation
    of P2Y(1) receptors by ATP is the possible mechanism for the inhibition of LTD
    in prefrontal cortex.
acknowledgement: " The financial support of the Deutsche Forschungsgemeinschaft (IL
  20/12-1, KI 677/2-4) is gratefully acknowledged.\r\nWe thank B. H. Koller (Department
  of Genetics and Molecular Biology, University of North Carolina at Chapel Hill,
  NC, USA) for the generous supply of P2Y1−/− and P2Y2−/− mice. We are grateful to
  Dr. A. Schulz for reanalysing the genotype of the P2Y1−/− mice. The authors thank
  P. Jonas and U. Heinemann for many helpful comments and A-K. Krause, L Feige and
  M. Eberts for their excellent technical support."
author:
- first_name: José
  full_name: Guzmán, José
  id: 30CC5506-F248-11E8-B48F-1D18A9856A87
  last_name: Guzmán
- first_name: Hartmut
  full_name: Schmidt, Hartmut
  last_name: Schmidt
- first_name: Heike
  full_name: Franke, Heike
  last_name: Franke
- first_name: Ute
  full_name: Krügel, Ute
  last_name: Krügel
- first_name: Jens
  full_name: Eilers, Jens
  last_name: Eilers
- first_name: Peter
  full_name: Illes, Peter
  last_name: Illes
- first_name: Zoltan
  full_name: Gerevich, Zoltan
  last_name: Gerevich
citation:
  ama: Guzmán J, Schmidt H, Franke H, et al. P2Y1 receptors inhibit long-term depression
    in the prefrontal cortex. <i>Neuropharmacology</i>. 2010;59(6):406-415. doi:<a
    href="https://doi.org/10.1016/j.neuropharm.2010.05.013">10.1016/j.neuropharm.2010.05.013</a>
  apa: Guzmán, J., Schmidt, H., Franke, H., Krügel, U., Eilers, J., Illes, P., &#38;
    Gerevich, Z. (2010). P2Y1 receptors inhibit long-term depression in the prefrontal
    cortex. <i>Neuropharmacology</i>. Elsevier. <a href="https://doi.org/10.1016/j.neuropharm.2010.05.013">https://doi.org/10.1016/j.neuropharm.2010.05.013</a>
  chicago: Guzmán, José, Hartmut Schmidt, Heike Franke, Ute Krügel, Jens Eilers, Peter
    Illes, and Zoltan Gerevich. “P2Y1 Receptors Inhibit Long-Term Depression in the
    Prefrontal Cortex.” <i>Neuropharmacology</i>. Elsevier, 2010. <a href="https://doi.org/10.1016/j.neuropharm.2010.05.013">https://doi.org/10.1016/j.neuropharm.2010.05.013</a>.
  ieee: J. Guzmán <i>et al.</i>, “P2Y1 receptors inhibit long-term depression in the
    prefrontal cortex.,” <i>Neuropharmacology</i>, vol. 59, no. 6. Elsevier, pp. 406–415,
    2010.
  ista: Guzmán J, Schmidt H, Franke H, Krügel U, Eilers J, Illes P, Gerevich Z. 2010.
    P2Y1 receptors inhibit long-term depression in the prefrontal cortex. Neuropharmacology.
    59(6), 406–415.
  mla: Guzmán, José, et al. “P2Y1 Receptors Inhibit Long-Term Depression in the Prefrontal
    Cortex.” <i>Neuropharmacology</i>, vol. 59, no. 6, Elsevier, 2010, pp. 406–15,
    doi:<a href="https://doi.org/10.1016/j.neuropharm.2010.05.013">10.1016/j.neuropharm.2010.05.013</a>.
  short: J. Guzmán, H. Schmidt, H. Franke, U. Krügel, J. Eilers, P. Illes, Z. Gerevich,
    Neuropharmacology 59 (2010) 406–415.
date_created: 2018-12-11T12:04:47Z
date_published: 2010-11-01T00:00:00Z
date_updated: 2021-01-12T07:51:42Z
day: '01'
department:
- _id: PeJo
doi: 10.1016/j.neuropharm.2010.05.013
intvolume: '        59'
issue: '6'
language:
- iso: eng
month: '11'
oa_version: None
page: 406 - 415
publication: Neuropharmacology
publication_status: published
publisher: Elsevier
publist_id: '2512'
quality_controlled: '1'
scopus_import: 1
status: public
title: P2Y1 receptors inhibit long-term depression in the prefrontal cortex.
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 59
year: '2010'
...
---
_id: '3719'
abstract:
- lang: eng
  text: The induction of a signaling pathway is characterized by transient complex
    formation and mutual posttranslational modification of proteins. To faithfully
    capture this combinatorial process in a math- ematical model is an important challenge
    in systems biology. Exploiting the limited context on which most binding and modification
    events are conditioned, attempts have been made to reduce the com- binatorial
    complexity by quotienting the reachable set of molecular species, into species
    aggregates while preserving the deterministic semantics of the thermodynamic limit.
    Recently we proposed a quotienting that also preserves the stochastic semantics
    and that is complete in the sense that the semantics of individual species can
    be recovered from the aggregate semantics. In this paper we prove that this quotienting
    yields a sufficient condition for weak lumpability and that it gives rise to a
    backward Markov bisimulation between the original and aggregated transition system.
    We illustrate the framework on a case study of the EGF/insulin receptor crosstalk.
acknowledgement: Jérôme Feret’s contribution was partially supported by the ABSTRACTCELL
  ANR-Chair of Excellence. Heinz Koeppl acknowledges the support from the Swiss National
  Science Foundation, grant no. 200020-117975/1. Tatjana Petrov acknowledges the support
  from SystemsX.ch, the Swiss Initiative in Systems Biology.
alternative_title:
- EPTCS
arxiv: 1
author:
- first_name: Jérôme
  full_name: Feret, Jérôme
  last_name: Feret
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
- first_name: Heinz
  full_name: Koeppl, Heinz
  last_name: Koeppl
- first_name: Tatjana
  full_name: Petrov, Tatjana
  id: 3D5811FC-F248-11E8-B48F-1D18A9856A87
  last_name: Petrov
  orcid: 0000-0002-9041-0905
citation:
  ama: 'Feret J, Henzinger TA, Koeppl H, Petrov T. Lumpability abstractions of rule-based
    systems. In: Vol 40. Open Publishing Association; 2010:142-161.'
  apa: 'Feret, J., Henzinger, T. A., Koeppl, H., &#38; Petrov, T. (2010). Lumpability
    abstractions of rule-based systems (Vol. 40, pp. 142–161). Presented at the MECBIC:
    Membrane Computing and Biologically Inspired Process Calculi, Jena, Germany: Open
    Publishing Association.'
  chicago: Feret, Jérôme, Thomas A Henzinger, Heinz Koeppl, and Tatjana Petrov. “Lumpability
    Abstractions of Rule-Based Systems,” 40:142–61. Open Publishing Association, 2010.
  ieee: 'J. Feret, T. A. Henzinger, H. Koeppl, and T. Petrov, “Lumpability abstractions
    of rule-based systems,” presented at the MECBIC: Membrane Computing and Biologically
    Inspired Process Calculi, Jena, Germany, 2010, vol. 40, pp. 142–161.'
  ista: 'Feret J, Henzinger TA, Koeppl H, Petrov T. 2010. Lumpability abstractions
    of rule-based systems. MECBIC: Membrane Computing and Biologically Inspired Process
    Calculi, EPTCS, vol. 40, 142–161.'
  mla: Feret, Jérôme, et al. <i>Lumpability Abstractions of Rule-Based Systems</i>.
    Vol. 40, Open Publishing Association, 2010, pp. 142–61.
  short: J. Feret, T.A. Henzinger, H. Koeppl, T. Petrov, in:, Open Publishing Association,
    2010, pp. 142–161.
conference:
  end_date: 2010-08-23
  location: Jena, Germany
  name: 'MECBIC: Membrane Computing and Biologically Inspired Process Calculi'
  start_date: 2010-08-23
date_created: 2018-12-11T12:04:47Z
date_published: 2010-10-30T00:00:00Z
date_updated: 2023-02-23T11:15:19Z
day: '30'
ddc:
- '570'
department:
- _id: ToHe
- _id: CaGu
external_id:
  arxiv:
  - '1011.0496'
file:
- access_level: open_access
  checksum: eaaba991a86fff37606b0eb5196878e8
  content_type: application/pdf
  creator: kschuh
  date_created: 2019-01-31T12:09:09Z
  date_updated: 2020-07-14T12:46:14Z
  file_id: '5904'
  file_name: Lumpability_abstractions_of_rule-based_systems.pdf
  file_size: 907155
  relation: main_file
file_date_updated: 2020-07-14T12:46:14Z
has_accepted_license: '1'
intvolume: '        40'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Submitted Version
page: 142-161
publication_status: published
publisher: Open Publishing Association
publist_id: '2511'
quality_controlled: '1'
related_material:
  record:
  - id: '3168'
    relation: later_version
    status: public
scopus_import: 1
status: public
title: Lumpability abstractions of rule-based systems
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 40
year: '2010'
...
---
_id: '3735'
abstract:
- lang: eng
  text: 'The visual system is challenged with extracting and representing behaviorally
    relevant information contained in natural inputs of great complexity and detail.
    This task begins in the sensory periphery: retinal receptive fields and circuits
    are matched to the first and second-order statistical structure of natural inputs.
    This matching enables the retina to remove stimulus components that are predictable
    (and therefore uninformative), and primarily transmit what is unpredictable (and
    therefore informative). Here we show that this design principle applies to more
    complex aspects of natural scenes, and to central visual processing. We do this
    by classifying high-order statistics of natural scenes according to whether they
    are uninformative vs. informative. We find that the uninformative ones are perceptually
    nonsalient, while the informative ones are highly salient, and correspond to previously
    identified perceptual mechanisms whose neural basis is likely central. Our results
    suggest that the principle of efficient coding not only accounts for filtering
    operations in the sensory periphery, but also shapes subsequent stages of sensory
    processing that are sensitive to high-order image statistics.'
author:
- first_name: Gasper
  full_name: Gasper Tkacik
  id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
  last_name: Tkacik
  orcid: 0000-0002-6699-1455
- first_name: Jason
  full_name: Prentice, Jason S
  last_name: Prentice
- first_name: Jonathan
  full_name: Victor,Jonathan D
  last_name: Victor
- first_name: Vijay
  full_name: Balasubramanian, Vijay
  last_name: Balasubramanian
citation:
  ama: Tkačik G, Prentice J, Victor J, Balasubramanian V. Local statistics in natural
    scenes predict the saliency of synthetic textures. <i>PNAS</i>. 2010;107(42):18149-18154.
    doi:<a href="https://doi.org/10.1073/pnas.0914916107">10.1073/pnas.0914916107</a>
  apa: Tkačik, G., Prentice, J., Victor, J., &#38; Balasubramanian, V. (2010). Local
    statistics in natural scenes predict the saliency of synthetic textures. <i>PNAS</i>.
    National Academy of Sciences. <a href="https://doi.org/10.1073/pnas.0914916107">https://doi.org/10.1073/pnas.0914916107</a>
  chicago: Tkačik, Gašper, Jason Prentice, Jonathan Victor, and Vijay Balasubramanian.
    “Local Statistics in Natural Scenes Predict the Saliency of Synthetic Textures.”
    <i>PNAS</i>. National Academy of Sciences, 2010. <a href="https://doi.org/10.1073/pnas.0914916107">https://doi.org/10.1073/pnas.0914916107</a>.
  ieee: G. Tkačik, J. Prentice, J. Victor, and V. Balasubramanian, “Local statistics
    in natural scenes predict the saliency of synthetic textures,” <i>PNAS</i>, vol.
    107, no. 42. National Academy of Sciences, pp. 18149–18154, 2010.
  ista: Tkačik G, Prentice J, Victor J, Balasubramanian V. 2010. Local statistics
    in natural scenes predict the saliency of synthetic textures. PNAS. 107(42), 18149–18154.
  mla: Tkačik, Gašper, et al. “Local Statistics in Natural Scenes Predict the Saliency
    of Synthetic Textures.” <i>PNAS</i>, vol. 107, no. 42, National Academy of Sciences,
    2010, pp. 18149–54, doi:<a href="https://doi.org/10.1073/pnas.0914916107">10.1073/pnas.0914916107</a>.
  short: G. Tkačik, J. Prentice, J. Victor, V. Balasubramanian, PNAS 107 (2010) 18149–18154.
date_created: 2018-12-11T12:04:53Z
date_published: 2010-10-19T00:00:00Z
date_updated: 2021-01-12T07:51:49Z
day: '19'
doi: 10.1073/pnas.0914916107
extern: 1
intvolume: '       107'
issue: '42'
main_file_link:
- open_access: '0'
  url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964243/
month: '10'
page: 18149 - 18154
publication: PNAS
publication_status: published
publisher: National Academy of Sciences
publist_id: '2491'
quality_controlled: 0
status: public
title: Local statistics in natural scenes predict the saliency of synthetic textures
type: journal_article
volume: 107
year: '2010'
...
---
_id: '3736'
abstract:
- lang: eng
  text: In retina and in cortical slice the collective response of spiking neural
    populations is well described by &quot;maximum-entropy&quot; models in which only
    pairs of neurons interact. We asked, how should such interactions be organized
    to maximize the amount of information represented in population responses? To
    this end, we extended the linear-nonlinear-Poisson model of single neural response
    to include pairwise interactions, yielding a stimulus-dependent, pairwise maximum-entropy
    model. We found that as we varied the noise level in single neurons and the distribution
    of network inputs, the optimal pairwise interactions smoothly interpolated to
    achieve network functions that are usually regarded as discrete–stimulus decorrelation,
    error correction, and independent encoding. These functions reflected a trade-off
    between efficient consumption of finite neural bandwidth and the use of redundancy
    to mitigate noise. Spontaneous activity in the optimal network reflected stimulus-induced
    activity patterns, and single-neuron response variability overestimated network
    noise. Our analysis suggests that rather than having a single coding principle
    hardwired in their architecture, networks in the brain should adapt their function
    to changing noise and stimulus correlations.
acknowledgement: R01 EY08124/EY/NEI NIH HHS/United States; T32-07035/PHS HHS/United
  States
author:
- first_name: Gasper
  full_name: Gasper Tkacik
  id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
  last_name: Tkacik
  orcid: 0000-0002-6699-1455
- first_name: Jason
  full_name: Prentice, Jason S
  last_name: Prentice
- first_name: Vijay
  full_name: Balasubramanian, Vijay
  last_name: Balasubramanian
- first_name: Elad
  full_name: Schneidman, Elad
  last_name: Schneidman
citation:
  ama: Tkačik G, Prentice J, Balasubramanian V, Schneidman E. Optimal population coding
    by noisy spiking neurons. <i>PNAS</i>. 2010;107(32):14419-14424. doi:<a href="https://doi.org/10.1073/pnas.1004906107">10.1073/pnas.1004906107</a>
  apa: Tkačik, G., Prentice, J., Balasubramanian, V., &#38; Schneidman, E. (2010).
    Optimal population coding by noisy spiking neurons. <i>PNAS</i>. National Academy
    of Sciences. <a href="https://doi.org/10.1073/pnas.1004906107">https://doi.org/10.1073/pnas.1004906107</a>
  chicago: Tkačik, Gašper, Jason Prentice, Vijay Balasubramanian, and Elad Schneidman.
    “Optimal Population Coding by Noisy Spiking Neurons.” <i>PNAS</i>. National Academy
    of Sciences, 2010. <a href="https://doi.org/10.1073/pnas.1004906107">https://doi.org/10.1073/pnas.1004906107</a>.
  ieee: G. Tkačik, J. Prentice, V. Balasubramanian, and E. Schneidman, “Optimal population
    coding by noisy spiking neurons,” <i>PNAS</i>, vol. 107, no. 32. National Academy
    of Sciences, pp. 14419–14424, 2010.
  ista: Tkačik G, Prentice J, Balasubramanian V, Schneidman E. 2010. Optimal population
    coding by noisy spiking neurons. PNAS. 107(32), 14419–14424.
  mla: Tkačik, Gašper, et al. “Optimal Population Coding by Noisy Spiking Neurons.”
    <i>PNAS</i>, vol. 107, no. 32, National Academy of Sciences, 2010, pp. 14419–24,
    doi:<a href="https://doi.org/10.1073/pnas.1004906107">10.1073/pnas.1004906107</a>.
  short: G. Tkačik, J. Prentice, V. Balasubramanian, E. Schneidman, PNAS 107 (2010)
    14419–14424.
date_created: 2018-12-11T12:04:53Z
date_published: 2010-08-10T00:00:00Z
date_updated: 2021-01-12T07:51:50Z
day: '10'
doi: 10.1073/pnas.1004906107
extern: 1
intvolume: '       107'
issue: '32'
main_file_link:
- open_access: '0'
  url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922524/
month: '08'
page: 14419 - 14424
publication: PNAS
publication_status: published
publisher: National Academy of Sciences
publist_id: '2492'
quality_controlled: 0
status: public
title: Optimal population coding by noisy spiking neurons
type: journal_article
volume: 107
year: '2010'
...
---
_id: '3738'
abstract:
- lang: eng
  text: Central to the functioning of a living cell is its ability to control the
    readout or expression of information encoded in the genome. In many cases, a single
    transcription factor protein activates or represses the expression of many genes.
    As the concentration of the transcription factor varies, the target genes thus
    undergo correlated changes, and this redundancy limits the ability of the cell
    to transmit information about input signals. We explore how interactions among
    the target genes can reduce this redundancy and optimize information transmission.
    Our discussion builds on recent work [Tkacik, Phys. Rev. E 80, 031920 (2009)],
    and there are connections to much earlier work on the role of lateral inhibition
    in enhancing the efficiency of information transmission in neural circuits; for
    simplicity we consider here the case where the interactions have a feed forward
    structure, with no loops. Even with this limitation, the networks that optimize
    information transmission have a structure reminiscent of the networks found in
    real biological systems.
author:
- first_name: Aleksandra
  full_name: Walczak, Aleksandra M
  last_name: Walczak
- first_name: Gasper
  full_name: Gasper Tkacik
  id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
  last_name: Tkacik
  orcid: 0000-0002-6699-1455
- first_name: William
  full_name: Bialek, William S
  last_name: Bialek
citation:
  ama: Walczak A, Tkačik G, Bialek W. Optimizing information flow in small genetic
    networks. II. Feed-forward interactions. <i>Physical Review E Statistical Nonlinear
    and Soft Matter Physics</i>. 2010;81(4). doi:<a href="https://doi.org/10.1103/PhysRevE.81.041905">10.1103/PhysRevE.81.041905</a>
  apa: Walczak, A., Tkačik, G., &#38; Bialek, W. (2010). Optimizing information flow
    in small genetic networks. II. Feed-forward interactions. <i>Physical Review E
    Statistical Nonlinear and Soft Matter Physics</i>. American Institute of Physics.
    <a href="https://doi.org/10.1103/PhysRevE.81.041905">https://doi.org/10.1103/PhysRevE.81.041905</a>
  chicago: Walczak, Aleksandra, Gašper Tkačik, and William Bialek. “Optimizing Information
    Flow in Small Genetic Networks. II. Feed-Forward Interactions.” <i>Physical Review
    E Statistical Nonlinear and Soft Matter Physics</i>. American Institute of Physics,
    2010. <a href="https://doi.org/10.1103/PhysRevE.81.041905">https://doi.org/10.1103/PhysRevE.81.041905</a>.
  ieee: A. Walczak, G. Tkačik, and W. Bialek, “Optimizing information flow in small
    genetic networks. II. Feed-forward interactions,” <i>Physical Review E Statistical
    Nonlinear and Soft Matter Physics</i>, vol. 81, no. 4. American Institute of Physics,
    2010.
  ista: Walczak A, Tkačik G, Bialek W. 2010. Optimizing information flow in small
    genetic networks. II. Feed-forward interactions. Physical Review E Statistical
    Nonlinear and Soft Matter Physics. 81(4).
  mla: Walczak, Aleksandra, et al. “Optimizing Information Flow in Small Genetic Networks.
    II. Feed-Forward Interactions.” <i>Physical Review E Statistical Nonlinear and
    Soft Matter Physics</i>, vol. 81, no. 4, American Institute of Physics, 2010,
    doi:<a href="https://doi.org/10.1103/PhysRevE.81.041905">10.1103/PhysRevE.81.041905</a>.
  short: A. Walczak, G. Tkačik, W. Bialek, Physical Review E Statistical Nonlinear
    and Soft Matter Physics 81 (2010).
date_created: 2018-12-11T12:04:54Z
date_published: 2010-04-06T00:00:00Z
date_updated: 2021-01-12T07:51:50Z
day: '06'
doi: 10.1103/PhysRevE.81.041905
extern: 1
intvolume: '        81'
issue: '4'
main_file_link:
- open_access: '0'
  url: http://arxiv.org/abs/0912.5500
month: '04'
publication: Physical Review E Statistical Nonlinear and Soft Matter Physics
publication_status: published
publisher: American Institute of Physics
publist_id: '2494'
quality_controlled: 0
status: public
title: Optimizing information flow in small genetic networks. II. Feed-forward interactions
type: journal_article
volume: 81
year: '2010'
...
---
_id: '3743'
abstract:
- lang: eng
  text: These are notes for a set of 7 two-hour lectures given at the 2010 Summer
    School on Quantitative Evolutionary and Comparative Genomics at OIST, Okinawa,
    Japan. The emphasis is on understanding how biological systems process information.
    We take a physicist's approach of looking for simple phenomenological descriptions
    that can address the questions of biological function without necessarily modeling
    all (mostly unknown) microscopic details; the example that is developed throughout
    the notes is transcriptional regulation in genetic regulatory networks. We present
    tools from information theory and statistical physics that can be used to analyze
    noisy nonlinear biological networks, and build generative and predictive models
    of regulatory processes.
author:
- first_name: Gasper
  full_name: Gasper Tkacik
  id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
  last_name: Tkacik
  orcid: 0000-0002-6699-1455
citation:
  ama: 'Tkačik G. From statistical mechanics to information theory: understanding
    biophysical information-processing systems. <i>ArXiv</i>. 2010;q-MN:1-52.'
  apa: 'Tkačik, G. (2010). From statistical mechanics to information theory: understanding
    biophysical information-processing systems. <i>ArXiv</i>. ArXiv.'
  chicago: 'Tkačik, Gašper. “From Statistical Mechanics to Information Theory: Understanding
    Biophysical Information-Processing Systems.” <i>ArXiv</i>. ArXiv, 2010.'
  ieee: 'G. Tkačik, “From statistical mechanics to information theory: understanding
    biophysical information-processing systems,” <i>ArXiv</i>, vol. q-MN. ArXiv, pp.
    1–52, 2010.'
  ista: 'Tkačik G. 2010. From statistical mechanics to information theory: understanding
    biophysical information-processing systems. ArXiv, q-MN, 1–52, .'
  mla: 'Tkačik, Gašper. “From Statistical Mechanics to Information Theory: Understanding
    Biophysical Information-Processing Systems.” <i>ArXiv</i>, vol. q-MN, ArXiv, 2010,
    pp. 1–52.'
  short: G. Tkačik, ArXiv q-MN (2010) 1–52.
date_created: 2018-12-11T12:04:55Z
date_published: 2010-06-22T00:00:00Z
date_updated: 2021-01-12T07:51:53Z
day: '22'
extern: 1
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/1006.4291v1
month: '06'
oa: 1
page: 1 - 52
publication: ArXiv
publication_status: published
publisher: ArXiv
publist_id: '2487'
quality_controlled: 0
status: public
title: 'From statistical mechanics to information theory: understanding biophysical
  information-processing systems'
type: preprint
volume: q-bio.MN
year: '2010'
...
---
_id: '3748'
abstract:
- lang: eng
  text: The chemotaxis signalling network in Escherichia coli that controls the locomotion
    of bacteria is a classic model system for signal transduction1, 2. This pathway
    modulates the behaviour of flagellar motors to propel bacteria towards sources
    of chemical attractants. Although this system relaxes to a steady state in response
    to environmental changes, the signalling events within the chemotaxis network
    are noisy and cause large temporal variations of the motor behaviour even in the
    absence of stimulus3. That the same signalling network governs both behavioural
    variability and cellular response raises the question of whether these two traits
    are independent. Here, we experimentally establish a fluctuation–response relationship
    in the chemotaxis system of living bacteria. Using this relationship, we demonstrate
    the possibility of inferring the cellular response from the behavioural variability
    measured before stimulus. In monitoring the pre- and post-stimulus switching behaviour
    of individual bacterial motors, we found that variability scales linearly with
    the response time for different functioning states of the cell. This study highlights
    that the fundamental relationship between fluctuation and response is not constrained
    to physical systems at thermodynamic equilibrium4 but is extensible to living
    cells5. Such a relationship not only implies that behavioural variability and
    cellular response can be coupled traits, but it also provides a general framework
    within which we can examine how the selection of a network design shapes this
    interdependence
author:
- first_name: Heungwon
  full_name: Park, Heungwon
  last_name: Park
- first_name: William
  full_name: Pontius, William
  last_name: Pontius
- first_name: Calin C
  full_name: Calin Guet
  id: 47F8433E-F248-11E8-B48F-1D18A9856A87
  last_name: Guet
  orcid: 0000-0001-6220-2052
- first_name: John
  full_name: Marko, John F
  last_name: Marko
- first_name: Thierry
  full_name: Emonet,Thierry
  last_name: Emonet
- first_name: Philippe
  full_name: Cluzel,Philippe
  last_name: Cluzel
citation:
  ama: Park H, Pontius W, Guet CC, Marko J, Emonet T, Cluzel P. Interdependence of
    behavioural variability and response to small stimuli in bacteria. <i>Nature</i>.
    2010;468:819-823. doi:<a href="https://doi.org/10.1038/nature09551">10.1038/nature09551</a>
  apa: Park, H., Pontius, W., Guet, C. C., Marko, J., Emonet, T., &#38; Cluzel, P.
    (2010). Interdependence of behavioural variability and response to small stimuli
    in bacteria. <i>Nature</i>. Nature Publishing Group. <a href="https://doi.org/10.1038/nature09551">https://doi.org/10.1038/nature09551</a>
  chicago: Park, Heungwon, William Pontius, Calin C Guet, John Marko, Thierry Emonet,
    and Philippe Cluzel. “Interdependence of Behavioural Variability and Response
    to Small Stimuli in Bacteria.” <i>Nature</i>. Nature Publishing Group, 2010. <a
    href="https://doi.org/10.1038/nature09551">https://doi.org/10.1038/nature09551</a>.
  ieee: H. Park, W. Pontius, C. C. Guet, J. Marko, T. Emonet, and P. Cluzel, “Interdependence
    of behavioural variability and response to small stimuli in bacteria,” <i>Nature</i>,
    vol. 468. Nature Publishing Group, pp. 819–823, 2010.
  ista: Park H, Pontius W, Guet CC, Marko J, Emonet T, Cluzel P. 2010. Interdependence
    of behavioural variability and response to small stimuli in bacteria. Nature.
    468, 819–823.
  mla: Park, Heungwon, et al. “Interdependence of Behavioural Variability and Response
    to Small Stimuli in Bacteria.” <i>Nature</i>, vol. 468, Nature Publishing Group,
    2010, pp. 819–23, doi:<a href="https://doi.org/10.1038/nature09551">10.1038/nature09551</a>.
  short: H. Park, W. Pontius, C.C. Guet, J. Marko, T. Emonet, P. Cluzel, Nature 468
    (2010) 819–823.
date_created: 2018-12-11T12:04:57Z
date_published: 2010-12-09T00:00:00Z
date_updated: 2021-01-12T07:51:55Z
day: '09'
doi: 10.1038/nature09551
extern: 1
intvolume: '       468'
main_file_link:
- open_access: '1'
  url: http://europepmc.org/articles/pmc3230254
month: '12'
oa: 1
page: 819 - 823
publication: Nature
publication_status: published
publisher: Nature Publishing Group
publist_id: '2480'
quality_controlled: 0
status: public
title: Interdependence of behavioural variability and response to small stimuli in
  bacteria
type: journal_article
volume: 468
year: '2010'
...
---
_id: '3749'
abstract:
- lang: eng
  text: 'In E. coli, chemotactic behavior exhibits perfect adaptation that is robust
    to changes in the intracellular concentration of the chemotactic proteins, such
    as CheR and CheB. However, the robustness of the perfect adaptation does not explicitly
    imply a robust chemotactic response. Previous studies on the robustness of the
    chemotactic response relied on swarming assays, which can be confounded by processes
    besides chemotaxis, such as cellular growth and depletion of nutrients. Here,
    using a high-throughput capillary assay that eliminates the effects of growth,
    we experimentally studied how the chemotactic response depends on the relative
    concentration of the chemotactic proteins. We simultaneously measured both the
    chemotactic response of E. coli cells to L: -aspartate and the concentrations
    of YFP-CheR and CheB-CFP fusion proteins. We found that the chemotactic response
    is fine-tuned to a specific ratio of [CheR]/[CheB] with a maximum response comparable
    to the chemotactic response of wild-type behavior. In contrast to adaptation in
    chemotaxis, that is robust and exact, capillary assays revealed that the chemotactic
    response in swimming bacteria is fined-tuned to wild-type level of the [CheR]/[CheB]
    ratio.'
acknowledgement: "P50 GM081892-04/GM/NIGMS NIH HHS/United States\nR01 AI059195-01A1/AI/NIAID
  NIH HHS/United States\nR01 AI059195-02/AI/NIAID NIH HHS/United States\nR01 AI059195-03/AI/NIAID
  NIH HHS/United States\nR01AI059195-03/AI/NIAID NIH HHS/United States\n\n\nPMCID:
  PMC3230253 "
author:
- first_name: Heungwon
  full_name: Park, Heungwon
  last_name: Park
- first_name: Calin C
  full_name: Calin Guet
  id: 47F8433E-F248-11E8-B48F-1D18A9856A87
  last_name: Guet
  orcid: 0000-0001-6220-2052
- first_name: Thierry
  full_name: Emonet,Thierry
  last_name: Emonet
- first_name: Philippe
  full_name: Cluzel,Philippe
  last_name: Cluzel
citation:
  ama: Park H, Guet CC, Emonet T, Cluzel P. Fine-tuning of chemotactic response in
    E. coli determined by high-throughput capillary assay. <i>Current Microbiology</i>.
    2010;62(3):764-769. doi:<a href="https://doi.org/10.1007/s00284-010-9778-z">10.1007/s00284-010-9778-z</a>
  apa: Park, H., Guet, C. C., Emonet, T., &#38; Cluzel, P. (2010). Fine-tuning of
    chemotactic response in E. coli determined by high-throughput capillary assay.
    <i>Current Microbiology</i>. Springer. <a href="https://doi.org/10.1007/s00284-010-9778-z">https://doi.org/10.1007/s00284-010-9778-z</a>
  chicago: Park, Heungwon, Calin C Guet, Thierry Emonet, and Philippe Cluzel. “Fine-Tuning
    of Chemotactic Response in E. Coli Determined by High-Throughput Capillary Assay.”
    <i>Current Microbiology</i>. Springer, 2010. <a href="https://doi.org/10.1007/s00284-010-9778-z">https://doi.org/10.1007/s00284-010-9778-z</a>.
  ieee: H. Park, C. C. Guet, T. Emonet, and P. Cluzel, “Fine-tuning of chemotactic
    response in E. coli determined by high-throughput capillary assay,” <i>Current
    Microbiology</i>, vol. 62, no. 3. Springer, pp. 764–769, 2010.
  ista: Park H, Guet CC, Emonet T, Cluzel P. 2010. Fine-tuning of chemotactic response
    in E. coli determined by high-throughput capillary assay. Current Microbiology.
    62(3), 764–769.
  mla: Park, Heungwon, et al. “Fine-Tuning of Chemotactic Response in E. Coli Determined
    by High-Throughput Capillary Assay.” <i>Current Microbiology</i>, vol. 62, no.
    3, Springer, 2010, pp. 764–69, doi:<a href="https://doi.org/10.1007/s00284-010-9778-z">10.1007/s00284-010-9778-z</a>.
  short: H. Park, C.C. Guet, T. Emonet, P. Cluzel, Current Microbiology 62 (2010)
    764–769.
date_created: 2018-12-11T12:04:57Z
date_published: 2010-10-23T00:00:00Z
date_updated: 2021-01-12T07:51:55Z
day: '23'
doi: 10.1007/s00284-010-9778-z
extern: 1
intvolume: '        62'
issue: '3'
main_file_link:
- open_access: '1'
  url: http://europepmc.org/articles/pmc3230253
month: '10'
oa: 1
page: 764 - 769
publication: Current Microbiology
publication_status: published
publisher: Springer
publist_id: '2479'
quality_controlled: 0
status: public
title: Fine-tuning of chemotactic response in E. coli determined by high-throughput
  capillary assay
type: journal_article
volume: 62
year: '2010'
...
---
_id: '3759'
abstract:
- lang: eng
  text: We propose a mesh-based surface tracking method for fluid animation that both
    preserves fine surface details and robustly adjusts the topology of the surface
    in the presence of arbitrarily thin features like sheets and strands. We replace
    traditional re-sampling methods with a convex hull method for connecting surface
    features during topological changes. This technique permits arbitrarily thin fluid
    features with minimal re-sampling errors by reusing points from the original surface.
    We further reduce re-sampling artifacts with a subdivision-based mesh-stitching
    algorithm, and we use a higher order interpolating subdivision scheme to determine
    the location of any newly-created vertices. The resulting algorithm efficiently
    produces detailed fluid surfaces with arbitrarily thin features while maintaining
    a consistent topology with the underlying fluid simulation.
article_processing_charge: No
author:
- first_name: Christopher J
  full_name: Wojtan, Christopher J
  id: 3C61F1D2-F248-11E8-B48F-1D18A9856A87
  last_name: Wojtan
  orcid: 0000-0001-6646-5546
- first_name: Nils
  full_name: Thürey, Nils
  last_name: Thürey
- first_name: Markus
  full_name: Gross, Markus
  last_name: Gross
- first_name: Greg
  full_name: Turk, Greg
  last_name: Turk
citation:
  ama: Wojtan C, Thürey N, Gross M, Turk G. Physics-inspired topology changes for
    thin fluid features. <i>ACM Transactions on Graphics</i>. 2010;29(4). doi:<a href="https://doi.org/10.1145/1778765.1778787">10.1145/1778765.1778787</a>
  apa: Wojtan, C., Thürey, N., Gross, M., &#38; Turk, G. (2010). Physics-inspired
    topology changes for thin fluid features. <i>ACM Transactions on Graphics</i>.
    ACM. <a href="https://doi.org/10.1145/1778765.1778787">https://doi.org/10.1145/1778765.1778787</a>
  chicago: Wojtan, Chris, Nils Thürey, Markus Gross, and Greg Turk. “Physics-Inspired
    Topology Changes for Thin Fluid Features.” <i>ACM Transactions on Graphics</i>.
    ACM, 2010. <a href="https://doi.org/10.1145/1778765.1778787">https://doi.org/10.1145/1778765.1778787</a>.
  ieee: C. Wojtan, N. Thürey, M. Gross, and G. Turk, “Physics-inspired topology changes
    for thin fluid features,” <i>ACM Transactions on Graphics</i>, vol. 29, no. 4.
    ACM, 2010.
  ista: Wojtan C, Thürey N, Gross M, Turk G. 2010. Physics-inspired topology changes
    for thin fluid features. ACM Transactions on Graphics. 29(4).
  mla: Wojtan, Chris, et al. “Physics-Inspired Topology Changes for Thin Fluid Features.”
    <i>ACM Transactions on Graphics</i>, vol. 29, no. 4, ACM, 2010, doi:<a href="https://doi.org/10.1145/1778765.1778787">10.1145/1778765.1778787</a>.
  short: C. Wojtan, N. Thürey, M. Gross, G. Turk, ACM Transactions on Graphics 29
    (2010).
date_created: 2018-12-11T12:05:00Z
date_published: 2010-01-01T00:00:00Z
date_updated: 2023-02-23T11:41:24Z
day: '01'
doi: 10.1145/1778765.1778787
extern: '1'
intvolume: '        29'
issue: '4'
language:
- iso: eng
main_file_link:
- url: http://kucg.korea.ac.kr/seminar/2010/src/paper-2010-09-02.pdf
month: '01'
oa_version: None
publication: ACM Transactions on Graphics
publication_status: published
publisher: ACM
publist_id: '2470'
status: public
title: Physics-inspired topology changes for thin fluid features
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 29
year: '2010'
...
---
_id: '3761'
abstract:
- lang: eng
  text: We present an algorithm for creating realistic animations of characters that
    are swimming through fluids. Our approach combines dynamic simulation with data-driven
    kinematic motions (motion capture data) to produce realistic animation in a fluid.
    The interaction of the articulated body with the fluid is performed by incorporating
    joint constraints with rigid animation and by extending a solid/fluid coupling
    method to handle articulated chains. Our solver takes as input the current state
    of the simulation and calculates the angular and linear accelerations of the connected
    bodies needed to match a particular motion sequence for the articulated body.
    These accelerations are used to estimate the forces and torques that are then
    applied to each joint. Based on this approach, we demonstrate simulated swimming
    results for a variety of different strokes, including crawl, backstroke, breaststroke,
    and butterfly. The ability to have articulated bodies interact with fluids also
    allows us to generate simulations of simple water creatures that are driven by
    simple controllers.
article_processing_charge: No
author:
- first_name: Nipun
  full_name: Kwatra, Nipun
  last_name: Kwatra
- first_name: Christopher J
  full_name: Wojtan, Christopher J
  id: 3C61F1D2-F248-11E8-B48F-1D18A9856A87
  last_name: Wojtan
  orcid: 0000-0001-6646-5546
- first_name: Mark
  full_name: Carlson, Mark
  last_name: Carlson
- first_name: Irfan
  full_name: Essa, Irfan
  last_name: Essa
- first_name: Peter
  full_name: Mucha, Peter
  last_name: Mucha
- first_name: Greg
  full_name: Turk, Greg
  last_name: Turk
citation:
  ama: Kwatra N, Wojtan C, Carlson M, Essa I, Mucha P, Turk G. Fluid simulation with
    articulated bodies. <i>IEEE Transactions on Visualization and Computer Graphics</i>.
    2010;16(1):70-80. doi:<a href="https://doi.org/10.1109/TVCG.2009.66">10.1109/TVCG.2009.66</a>
  apa: Kwatra, N., Wojtan, C., Carlson, M., Essa, I., Mucha, P., &#38; Turk, G. (2010).
    Fluid simulation with articulated bodies. <i>IEEE Transactions on Visualization
    and Computer Graphics</i>. IEEE. <a href="https://doi.org/10.1109/TVCG.2009.66">https://doi.org/10.1109/TVCG.2009.66</a>
  chicago: Kwatra, Nipun, Chris Wojtan, Mark Carlson, Irfan Essa, Peter Mucha, and
    Greg Turk. “Fluid Simulation with Articulated Bodies.” <i>IEEE Transactions on
    Visualization and Computer Graphics</i>. IEEE, 2010. <a href="https://doi.org/10.1109/TVCG.2009.66">https://doi.org/10.1109/TVCG.2009.66</a>.
  ieee: N. Kwatra, C. Wojtan, M. Carlson, I. Essa, P. Mucha, and G. Turk, “Fluid simulation
    with articulated bodies,” <i>IEEE Transactions on Visualization and Computer Graphics</i>,
    vol. 16, no. 1. IEEE, pp. 70–80, 2010.
  ista: Kwatra N, Wojtan C, Carlson M, Essa I, Mucha P, Turk G. 2010. Fluid simulation
    with articulated bodies. IEEE Transactions on Visualization and Computer Graphics.
    16(1), 70–80.
  mla: Kwatra, Nipun, et al. “Fluid Simulation with Articulated Bodies.” <i>IEEE Transactions
    on Visualization and Computer Graphics</i>, vol. 16, no. 1, IEEE, 2010, pp. 70–80,
    doi:<a href="https://doi.org/10.1109/TVCG.2009.66">10.1109/TVCG.2009.66</a>.
  short: N. Kwatra, C. Wojtan, M. Carlson, I. Essa, P. Mucha, G. Turk, IEEE Transactions
    on Visualization and Computer Graphics 16 (2010) 70–80.
date_created: 2018-12-11T12:05:01Z
date_published: 2010-01-01T00:00:00Z
date_updated: 2023-02-23T11:41:31Z
day: '01'
doi: 10.1109/TVCG.2009.66
extern: '1'
intvolume: '        16'
issue: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 70 - 80
publication: IEEE Transactions on Visualization and Computer Graphics
publication_status: published
publisher: IEEE
publist_id: '2468'
status: public
title: Fluid simulation with articulated bodies
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 16
year: '2010'
...
---
_id: '3766'
abstract:
- lang: eng
  text: 'We present an approach to simulate flows driven by surface tension based
    on triangle meshes. Our method consists of two simulation layers: the first layer
    is an Eulerian method for simulating surface tension forces that is free from
    typical strict time step constraints. The second simulation layer is a Lagrangian
    finite element method that simulates sub-grid scale wave details on the fluid
    surface. The surface wave simulation employs an unconditionally stable, symplectic
    time integration method that allows for a high propagation speed due to strong
    surface tension. Our approach can naturally separate the grid-and sub-grid scales
    based on a volumepreserving mean curvature flow. As our model for the sub-grid
    dynamics enforces a local conservation of mass, it leads to realistic pinch off
    and merging effects. In addition to this method for simulating dynamic surface
    tension effects, we also present an efficient non-oscillatory approximation for
    capturing damped surface tension behavior. These approaches allow us to efficiently
    simulate complex phenomena associated with strong surface tension, such as Rayleigh-Plateau
    instabilities and crown splashes, in a short amount of time.'
article_processing_charge: No
author:
- first_name: Nils
  full_name: Thürey, Nils
  last_name: Thürey
- first_name: Christopher J
  full_name: Wojtan, Christopher J
  id: 3C61F1D2-F248-11E8-B48F-1D18A9856A87
  last_name: Wojtan
  orcid: 0000-0001-6646-5546
- first_name: Markus
  full_name: Gross, Markus
  last_name: Gross
- first_name: Greg
  full_name: Turk, Greg
  last_name: Turk
citation:
  ama: Thürey N, Wojtan C, Gross M, Turk G. A multiscale approach to mesh-based surface
    tension flows. <i>ACM Transactions on Graphics</i>. 2010;29(4). doi:<a href="https://doi.org/10.1145/1778765.1778785">10.1145/1778765.1778785</a>
  apa: Thürey, N., Wojtan, C., Gross, M., &#38; Turk, G. (2010). A multiscale approach
    to mesh-based surface tension flows. <i>ACM Transactions on Graphics</i>. ACM.
    <a href="https://doi.org/10.1145/1778765.1778785">https://doi.org/10.1145/1778765.1778785</a>
  chicago: Thürey, Nils, Chris Wojtan, Markus Gross, and Greg Turk. “A Multiscale
    Approach to Mesh-Based Surface Tension Flows.” <i>ACM Transactions on Graphics</i>.
    ACM, 2010. <a href="https://doi.org/10.1145/1778765.1778785">https://doi.org/10.1145/1778765.1778785</a>.
  ieee: N. Thürey, C. Wojtan, M. Gross, and G. Turk, “A multiscale approach to mesh-based
    surface tension flows,” <i>ACM Transactions on Graphics</i>, vol. 29, no. 4. ACM,
    2010.
  ista: Thürey N, Wojtan C, Gross M, Turk G. 2010. A multiscale approach to mesh-based
    surface tension flows. ACM Transactions on Graphics. 29(4).
  mla: Thürey, Nils, et al. “A Multiscale Approach to Mesh-Based Surface Tension Flows.”
    <i>ACM Transactions on Graphics</i>, vol. 29, no. 4, ACM, 2010, doi:<a href="https://doi.org/10.1145/1778765.1778785">10.1145/1778765.1778785</a>.
  short: N. Thürey, C. Wojtan, M. Gross, G. Turk, ACM Transactions on Graphics 29
    (2010).
date_created: 2018-12-11T12:05:03Z
date_published: 2010-07-01T00:00:00Z
date_updated: 2023-02-23T11:41:44Z
day: '01'
doi: 10.1145/1778765.1778785
extern: '1'
intvolume: '        29'
issue: '4'
language:
- iso: eng
month: '07'
oa_version: None
publication: ACM Transactions on Graphics
publication_status: published
publisher: ACM
publist_id: '2463'
status: public
title: A multiscale approach to mesh-based surface tension flows
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 29
year: '2010'
...
---
_id: '3772'
article_number: e1000987
author:
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
citation:
  ama: Barton NH. Understanding adaptation in large populations. <i>PLoS Genetics</i>.
    2010;6(6). doi:<a href="https://doi.org/10.1371/journal.pgen.1000987">10.1371/journal.pgen.1000987</a>
  apa: Barton, N. H. (2010). Understanding adaptation in large populations. <i>PLoS
    Genetics</i>. Public Library of Science. <a href="https://doi.org/10.1371/journal.pgen.1000987">https://doi.org/10.1371/journal.pgen.1000987</a>
  chicago: Barton, Nicholas H. “Understanding Adaptation in Large Populations.” <i>PLoS
    Genetics</i>. Public Library of Science, 2010. <a href="https://doi.org/10.1371/journal.pgen.1000987">https://doi.org/10.1371/journal.pgen.1000987</a>.
  ieee: N. H. Barton, “Understanding adaptation in large populations,” <i>PLoS Genetics</i>,
    vol. 6, no. 6. Public Library of Science, 2010.
  ista: Barton NH. 2010. Understanding adaptation in large populations. PLoS Genetics.
    6(6), e1000987.
  mla: Barton, Nicholas H. “Understanding Adaptation in Large Populations.” <i>PLoS
    Genetics</i>, vol. 6, no. 6, e1000987, Public Library of Science, 2010, doi:<a
    href="https://doi.org/10.1371/journal.pgen.1000987">10.1371/journal.pgen.1000987</a>.
  short: N.H. Barton, PLoS Genetics 6 (2010).
date_created: 2018-12-11T12:05:05Z
date_published: 2010-06-17T00:00:00Z
date_updated: 2021-01-12T07:52:05Z
day: '17'
ddc:
- '570'
- '576'
department:
- _id: NiBa
doi: 10.1371/journal.pgen.1000987
file:
- access_level: open_access
  checksum: 5c14de2680ab483cb835096c99ee734d
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:14:24Z
  date_updated: 2020-07-14T12:46:15Z
  file_id: '5075'
  file_name: IST-2016-524-v1+1_journal.pgen.1000987.PDF
  file_size: 349965
  relation: main_file
file_date_updated: 2020-07-14T12:46:15Z
has_accepted_license: '1'
intvolume: '         6'
issue: '6'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
publication: PLoS Genetics
publication_status: published
publisher: Public Library of Science
publist_id: '2454'
pubrep_id: '524'
quality_controlled: '1'
scopus_import: 1
status: public
title: Understanding adaptation in large populations
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 6
year: '2010'
...
---
_id: '3773'
abstract:
- lang: eng
  text: If distinct biological species are to coexist in sympatry, they must be reproductively
    isolated and must exploit different limiting resources. A two-niche Levene model
    is analysed, in which habitat preference and survival depend on underlying additive
    traits. The population genetics of preference and viability are equivalent. However,
    there is a linear trade-off between the chances of settling in either niche, whereas
    viabilities may be constrained arbitrarily. With a convex trade-off, a sexual
    population evolves a single generalist genotype, whereas with a concave trade-off,
    disruptive selection favours maximal variance. A pure habitat preference evolves
    to global linkage equilibrium if mating occurs in a single pool, but remarkably,
    evolves to pairwise linkage equilibrium within niches if mating is within those
    niches--independent of the genetics. With a concave trade-off, the population
    shifts sharply between a unimodal distribution with high gene flow and a bimodal
    distribution with strong isolation, as the underlying genetic variance increases.
    However, these alternative states are only simultaneously stable for a narrow
    parameter range. A sharp threshold is only seen if survival in the 'wrong' niche
    is low; otherwise, strong isolation is impossible. Gene flow from divergent demes
    makes speciation much easier in parapatry than in sympatry.
acknowledgement: "The author thanks the Werner-Gren Foundation and the Royal Swedish
  Academy of Sciences for organizing the symposium on the ‘Origin of Species’. He
  also thanks Reinhard Bürger, and two anonymous referees, for their helpful comments.\r\n"
author:
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
citation:
  ama: Barton NH. What role does natural selection play in speciation? <i>Philosophical
    Transactions of the Royal Society of London Series B, Biological Sciences</i>.
    2010;365(1547):1825-1840. doi:<a href="https://doi.org/10.1098/rstb.2010.0001">10.1098/rstb.2010.0001</a>
  apa: Barton, N. H. (2010). What role does natural selection play in speciation?
    <i>Philosophical Transactions of the Royal Society of London. Series B, Biological
    Sciences</i>. Royal Society. <a href="https://doi.org/10.1098/rstb.2010.0001">https://doi.org/10.1098/rstb.2010.0001</a>
  chicago: Barton, Nicholas H. “What Role Does Natural Selection Play in Speciation?”
    <i>Philosophical Transactions of the Royal Society of London. Series B, Biological
    Sciences</i>. Royal Society, 2010. <a href="https://doi.org/10.1098/rstb.2010.0001">https://doi.org/10.1098/rstb.2010.0001</a>.
  ieee: N. H. Barton, “What role does natural selection play in speciation?,” <i>Philosophical
    Transactions of the Royal Society of London. Series B, Biological Sciences</i>,
    vol. 365, no. 1547. Royal Society, pp. 1825–1840, 2010.
  ista: Barton NH. 2010. What role does natural selection play in speciation? Philosophical
    Transactions of the Royal Society of London. Series B, Biological Sciences. 365(1547),
    1825–1840.
  mla: Barton, Nicholas H. “What Role Does Natural Selection Play in Speciation?”
    <i>Philosophical Transactions of the Royal Society of London. Series B, Biological
    Sciences</i>, vol. 365, no. 1547, Royal Society, 2010, pp. 1825–40, doi:<a href="https://doi.org/10.1098/rstb.2010.0001">10.1098/rstb.2010.0001</a>.
  short: N.H. Barton, Philosophical Transactions of the Royal Society of London. Series
    B, Biological Sciences 365 (2010) 1825–1840.
date_created: 2018-12-11T12:05:05Z
date_published: 2010-06-12T00:00:00Z
date_updated: 2021-01-12T07:52:06Z
day: '12'
department:
- _id: NiBa
doi: 10.1098/rstb.2010.0001
external_id:
  pmid:
  - '20439284'
intvolume: '       365'
issue: '1547'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://www.ncbi.nlm.nih.gov/pubmed/20439284
month: '06'
oa: 1
oa_version: Submitted Version
page: 1825 - 1840
pmid: 1
publication: Philosophical Transactions of the Royal Society of London. Series B,
  Biological Sciences
publication_status: published
publisher: Royal Society
publist_id: '2455'
quality_controlled: '1'
scopus_import: 1
status: public
title: What role does natural selection play in speciation?
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 365
year: '2010'
...
---
_id: '3774'
abstract:
- lang: eng
  text: 1. Hybridisation with an invasive species has the potential to alter the phenotype
    and hence the ecology of a native counterpart. 2. Here data from populations of
    native red deer Cervus elaphus and invasive sika deer Cervus nippon in Scotland
    is used to assess the extent to which hybridisation between them is causing phenotypic
    change. This is done by regression of phenotypic traits against genetic hybrid
    scores. 3. Hybridisation is causing increases in the body weight of sika-like
    deer and decreases in the body weight of red-like females. Hybridisation is causing
    increases in jaw length and increases in incisor arcade breadth in sika-like females.
    Hybridisation is also causing decreases in incisor arcade breadth in red-like
    females. 4. There is currently no evidence that hybridisation is causing changes
    in the kidney fat weight or pregnancy rates of either population. 5. Increased
    phenotypic similarity between the two species is likely to lead to further hybridisation.
    The ecological consequences of this are difficult to predict.
acknowledgement: "This project was funded through a NERC studentship to HVS which
  was CASE partnered by the Macaulay Institute.\r\nWe thank the Forestry Commission
  Scotland rangers for all their help with providing the larder data for and samples
  from red and sika deer, Stephen Senn and Jarrod Hadfield for statistical advice
  and Steve Albon for helpful comments on the manuscript."
author:
- first_name: Helen
  full_name: Senn, Helen
  last_name: Senn
- first_name: Graeme
  full_name: Swanson, Graeme
  last_name: Swanson
- first_name: Simon
  full_name: Goodman, Simon
  last_name: Goodman
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
- first_name: Josephine
  full_name: Pemberton, Josephine
  last_name: Pemberton
citation:
  ama: Senn H, Swanson G, Goodman S, Barton NH, Pemberton J. Phenotypic correlates
    of hybridisation between red and sika deer (genus Cervus). <i>Journal of Animal
    Ecology</i>. 2010;79(2):414-425. doi:<a href="https://doi.org/10.1111/j.1365-2656.2009.01633.x">10.1111/j.1365-2656.2009.01633.x</a>
  apa: Senn, H., Swanson, G., Goodman, S., Barton, N. H., &#38; Pemberton, J. (2010).
    Phenotypic correlates of hybridisation between red and sika deer (genus Cervus).
    <i>Journal of Animal Ecology</i>. Wiley-Blackwell. <a href="https://doi.org/10.1111/j.1365-2656.2009.01633.x">https://doi.org/10.1111/j.1365-2656.2009.01633.x</a>
  chicago: Senn, Helen, Graeme Swanson, Simon Goodman, Nicholas H Barton, and Josephine
    Pemberton. “Phenotypic Correlates of Hybridisation between Red and Sika Deer (Genus
    Cervus).” <i>Journal of Animal Ecology</i>. Wiley-Blackwell, 2010. <a href="https://doi.org/10.1111/j.1365-2656.2009.01633.x">https://doi.org/10.1111/j.1365-2656.2009.01633.x</a>.
  ieee: H. Senn, G. Swanson, S. Goodman, N. H. Barton, and J. Pemberton, “Phenotypic
    correlates of hybridisation between red and sika deer (genus Cervus),” <i>Journal
    of Animal Ecology</i>, vol. 79, no. 2. Wiley-Blackwell, pp. 414–425, 2010.
  ista: Senn H, Swanson G, Goodman S, Barton NH, Pemberton J. 2010. Phenotypic correlates
    of hybridisation between red and sika deer (genus Cervus). Journal of Animal Ecology.
    79(2), 414–425.
  mla: Senn, Helen, et al. “Phenotypic Correlates of Hybridisation between Red and
    Sika Deer (Genus Cervus).” <i>Journal of Animal Ecology</i>, vol. 79, no. 2, Wiley-Blackwell,
    2010, pp. 414–25, doi:<a href="https://doi.org/10.1111/j.1365-2656.2009.01633.x">10.1111/j.1365-2656.2009.01633.x</a>.
  short: H. Senn, G. Swanson, S. Goodman, N.H. Barton, J. Pemberton, Journal of Animal
    Ecology 79 (2010) 414–425.
date_created: 2018-12-11T12:05:06Z
date_published: 2010-03-01T00:00:00Z
date_updated: 2021-01-12T07:52:06Z
day: '01'
department:
- _id: NiBa
doi: 10.1111/j.1365-2656.2009.01633.x
external_id:
  pmid:
  - '20002231'
intvolume: '        79'
issue: '2'
language:
- iso: eng
month: '03'
oa_version: None
page: 414 - 425
pmid: 1
publication: Journal of Animal Ecology
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2453'
quality_controlled: '1'
scopus_import: 1
status: public
title: Phenotypic correlates of hybridisation between red and sika deer (genus Cervus)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 79
year: '2010'
...
---
_id: '3776'
abstract:
- lang: eng
  text: 'The prevalence of recombination in eukaryotes poses one of the most puzzling
    questions in biology. The most compelling general explanation is that recombination
    facilitates selection by breaking down the negative associations generated by
    random drift (i.e. Hill-Robertson interference, HRI). I classify the effects of
    HRI owing to: deleterious mutation, balancing selection and selective sweeps on:
    neutral diversity, rates of adaptation and the mutation load. These effects are
    mediated primarily by the density of deleterious mutations and of selective sweeps.
    Sequence polymorphism and divergence suggest that these rates may be high enough
    to cause significant interference even in genomic regions of high recombination.
    However, neither seems able to generate enough variance in fitness to select strongly
    for high rates of recombination. It is plausible that spatial and temporal fluctuations
    in selection generate much more fitness variance, and hence selection for recombination,
    than can be explained by uniformly deleterious mutations or species-wide selective
    sweeps.'
acknowledgement: "Royal Society and Wolfson Foundation for their support\r\nWe would
  like to thank Brian Charlesworth and Sally Otto for their helpful comments."
author:
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
citation:
  ama: Barton NH. Genetic linkage and natural selection. <i>Philosophical Transactions
    of the Royal Society of London Series B, Biological Sciences</i>. 2010;365(1552):2559-2569.
    doi:<a href="https://doi.org/10.1098/rstb.2010.0106">10.1098/rstb.2010.0106</a>
  apa: Barton, N. H. (2010). Genetic linkage and natural selection. <i>Philosophical
    Transactions of the Royal Society of London. Series B, Biological Sciences</i>.
    Royal Society. <a href="https://doi.org/10.1098/rstb.2010.0106">https://doi.org/10.1098/rstb.2010.0106</a>
  chicago: Barton, Nicholas H. “Genetic Linkage and Natural Selection.” <i>Philosophical
    Transactions of the Royal Society of London. Series B, Biological Sciences</i>.
    Royal Society, 2010. <a href="https://doi.org/10.1098/rstb.2010.0106">https://doi.org/10.1098/rstb.2010.0106</a>.
  ieee: N. H. Barton, “Genetic linkage and natural selection,” <i>Philosophical Transactions
    of the Royal Society of London. Series B, Biological Sciences</i>, vol. 365, no.
    1552. Royal Society, pp. 2559–2569, 2010.
  ista: Barton NH. 2010. Genetic linkage and natural selection. Philosophical Transactions
    of the Royal Society of London. Series B, Biological Sciences. 365(1552), 2559–2569.
  mla: Barton, Nicholas H. “Genetic Linkage and Natural Selection.” <i>Philosophical
    Transactions of the Royal Society of London. Series B, Biological Sciences</i>,
    vol. 365, no. 1552, Royal Society, 2010, pp. 2559–69, doi:<a href="https://doi.org/10.1098/rstb.2010.0106">10.1098/rstb.2010.0106</a>.
  short: N.H. Barton, Philosophical Transactions of the Royal Society of London. Series
    B, Biological Sciences 365 (2010) 2559–2569.
date_created: 2018-12-11T12:05:06Z
date_published: 2010-08-27T00:00:00Z
date_updated: 2021-01-12T07:52:07Z
day: '27'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.1098/rstb.2010.0106
file:
- access_level: open_access
  checksum: 4d8aade10db030124ab158b622e337e0
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:14:40Z
  date_updated: 2020-07-14T12:46:15Z
  file_id: '5093'
  file_name: IST-2016-555-v1+1_RS2009_revised.pdf
  file_size: 250255
  relation: main_file
file_date_updated: 2020-07-14T12:46:15Z
has_accepted_license: '1'
intvolume: '       365'
issue: '1552'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Submitted Version
page: 2559 - 2569
publication: Philosophical Transactions of the Royal Society of London. Series B,
  Biological Sciences
publication_status: published
publisher: Royal Society
publist_id: '2450'
pubrep_id: '555'
quality_controlled: '1'
scopus_import: 1
status: public
title: Genetic linkage and natural selection
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 365
year: '2010'
...
---
_id: '3777'
abstract:
- lang: eng
  text: 'Under the classical view, selection depends more or less directly on mutation:
    standing genetic variance is maintained by a balance between selection and mutation,
    and adaptation is fuelled by new favourable mutations. Recombination is favoured
    if it breaks negative associations among selected alleles, which interfere with
    adaptation. Such associations may be generated by negative epistasis, or by random
    drift (leading to the Hill-Robertson effect). Both deterministic and stochastic
    explanations depend primarily on the genomic mutation rate, U. This may be large
    enough to explain high recombination rates in some organisms, but seems unlikely
    to be so in general. Random drift is a more general source of negative linkage
    disequilibria, and can cause selection for recombination even in large populations,
    through the chance loss of new favourable mutations. The rate of species-wide
    substitutions is much too low to drive this mechanism, but local fluctuations
    in selection, combined with gene flow, may suffice. These arguments are illustrated
    by comparing the interaction between good and bad mutations at unlinked loci under
    the infinitesimal model.'
acknowledgement: I would like to thank W. G. Hill and L. Loewe for organizing this
  special issue, and the Royal Society and Wolfson Foundation for their support. Also,
  A. Kondrashov and L. Loewe gave very helpful comments that helped improve the manuscript.
author:
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
citation:
  ama: Barton NH. Mutation and the evolution of recombination. <i>Philosophical Transactions
    of the Royal Society of London Series B, Biological Sciences</i>. 2010;365(1544):1281-1294.
    doi:<a href="https://doi.org/10.1098/rstb.2009.0320">10.1098/rstb.2009.0320</a>
  apa: Barton, N. H. (2010). Mutation and the evolution of recombination. <i>Philosophical
    Transactions of the Royal Society of London. Series B, Biological Sciences</i>.
    Royal Society. <a href="https://doi.org/10.1098/rstb.2009.0320">https://doi.org/10.1098/rstb.2009.0320</a>
  chicago: Barton, Nicholas H. “Mutation and the Evolution of Recombination.” <i>Philosophical
    Transactions of the Royal Society of London. Series B, Biological Sciences</i>.
    Royal Society, 2010. <a href="https://doi.org/10.1098/rstb.2009.0320">https://doi.org/10.1098/rstb.2009.0320</a>.
  ieee: N. H. Barton, “Mutation and the evolution of recombination,” <i>Philosophical
    Transactions of the Royal Society of London. Series B, Biological Sciences</i>,
    vol. 365, no. 1544. Royal Society, pp. 1281–1294, 2010.
  ista: Barton NH. 2010. Mutation and the evolution of recombination. Philosophical
    Transactions of the Royal Society of London. Series B, Biological Sciences. 365(1544),
    1281–1294.
  mla: Barton, Nicholas H. “Mutation and the Evolution of Recombination.” <i>Philosophical
    Transactions of the Royal Society of London. Series B, Biological Sciences</i>,
    vol. 365, no. 1544, Royal Society, 2010, pp. 1281–94, doi:<a href="https://doi.org/10.1098/rstb.2009.0320">10.1098/rstb.2009.0320</a>.
  short: N.H. Barton, Philosophical Transactions of the Royal Society of London. Series
    B, Biological Sciences 365 (2010) 1281–1294.
date_created: 2018-12-11T12:05:07Z
date_published: 2010-04-27T00:00:00Z
date_updated: 2021-01-12T07:52:07Z
day: '27'
department:
- _id: NiBa
doi: 10.1098/rstb.2009.0320
external_id:
  pmid:
  - '20308104'
intvolume: '       365'
issue: '1544'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://www.ncbi.nlm.nih.gov/pubmed/20308104
month: '04'
oa: 1
oa_version: Submitted Version
page: 1281 - 1294
pmid: 1
publication: Philosophical Transactions of the Royal Society of London. Series B,
  Biological Sciences
publication_status: published
publisher: Royal Society
publist_id: '2451'
quality_controlled: '1'
scopus_import: 1
status: public
title: Mutation and the evolution of recombination
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 365
year: '2010'
...
---
_id: '3779'
abstract:
- lang: eng
  text: Crosses between closely related species give two contrasting results. One
    result is that species hybrids may be inferior to their parents, for example,
    being less fertile [1]. The other is that F1 hybrids may display superior performance
    (heterosis), for example with increased vigour [2]. Although various hypotheses
    have been proposed to account for these two aspects of hybridisation, their biological
    basis is still poorly understood [3]. To gain further insights into this issue,
    we analysed the role that variation in gene expression may play. We took a conserved
    trait, flower asymmetry in Antirrhinum, and determined the extent to which the
    underlying regulatory genes varied in expression among closely related species.
    We show that expression of both genes analysed, CYC and RAD, varies significantly
    between species because of cis-acting differences. By making a quantitative genotype-phenotype
    map, using a range of mutant alleles, we demonstrate that the species lie on a
    plateau in gene expression-morphology space, so that the variation has no detectable
    phenotypic effect. However, phenotypic differences can be revealed by shifting
    genotypes off the plateau through genetic crosses. Our results can be readily
    explained if genomes are free to evolve within an effectively neutral zone in
    gene expression space. The consequences of this drift will be negligible for individual
    loci, but when multiple loci across the genome are considered, we show that the
    variation may have significant effects on phenotype and fitness, causing a significant
    drift load. By considering these consequences for various gene-expression-fitness
    landscapes, we conclude that F1 hybrids might be expected to show increased performance
    with regard to conserved traits, such as basic physiology, but reduced performance
    with regard to others. Thus, our study provides a new way of explaining how various
    aspects of hybrid performance may arise through natural variation in gene activity.
acknowledgement: "This was supported by a Marie Curie grant for early stage training
  and the BBSRC-John Innes Centre PhD Rotation Program.\r\nWe would like to thank
  X. Feng and A. Hudson for assistance with introgressions and genotyping; A. Green,
  A. Bangham and J. Pateman for advice and assistance on shape model procedures; F.
  Alderson and S.Mitchell from JIC horticultural services; P.J. Wittkopp for protocols
  and advice on pyrosequencing; and R. Sablowski for discussions and comments.\r\n"
article_number: e1000429
author:
- first_name: Ulises
  full_name: Rosas, Ulises
  last_name: Rosas
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
- first_name: Lucy
  full_name: Copsey, Lucy
  last_name: Copsey
- first_name: Pierre
  full_name: Barbier De Reuille, Pierre
  last_name: Barbier De Reuille
- first_name: Enrico
  full_name: Coen, Enrico
  last_name: Coen
citation:
  ama: Rosas U, Barton NH, Copsey L, Barbier De Reuille P, Coen E. Cryptic variation
    between species and the basis of hybrid performance. <i>PLoS Biology</i>. 2010;8(7).
    doi:<a href="https://doi.org/10.1371/journal.pbio.1000429">10.1371/journal.pbio.1000429</a>
  apa: Rosas, U., Barton, N. H., Copsey, L., Barbier De Reuille, P., &#38; Coen, E.
    (2010). Cryptic variation between species and the basis of hybrid performance.
    <i>PLoS Biology</i>. Public Library of Science. <a href="https://doi.org/10.1371/journal.pbio.1000429">https://doi.org/10.1371/journal.pbio.1000429</a>
  chicago: Rosas, Ulises, Nicholas H Barton, Lucy Copsey, Pierre Barbier De Reuille,
    and Enrico Coen. “Cryptic Variation between Species and the Basis of Hybrid Performance.”
    <i>PLoS Biology</i>. Public Library of Science, 2010. <a href="https://doi.org/10.1371/journal.pbio.1000429">https://doi.org/10.1371/journal.pbio.1000429</a>.
  ieee: U. Rosas, N. H. Barton, L. Copsey, P. Barbier De Reuille, and E. Coen, “Cryptic
    variation between species and the basis of hybrid performance,” <i>PLoS Biology</i>,
    vol. 8, no. 7. Public Library of Science, 2010.
  ista: Rosas U, Barton NH, Copsey L, Barbier De Reuille P, Coen E. 2010. Cryptic
    variation between species and the basis of hybrid performance. PLoS Biology. 8(7),
    e1000429.
  mla: Rosas, Ulises, et al. “Cryptic Variation between Species and the Basis of Hybrid
    Performance.” <i>PLoS Biology</i>, vol. 8, no. 7, e1000429, Public Library of
    Science, 2010, doi:<a href="https://doi.org/10.1371/journal.pbio.1000429">10.1371/journal.pbio.1000429</a>.
  short: U. Rosas, N.H. Barton, L. Copsey, P. Barbier De Reuille, E. Coen, PLoS Biology
    8 (2010).
date_created: 2018-12-11T12:05:07Z
date_published: 2010-07-20T00:00:00Z
date_updated: 2023-02-23T14:07:34Z
day: '20'
ddc:
- '576'
department:
- _id: NiBa
doi: 10.1371/journal.pbio.1000429
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publication: PLoS Biology
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publisher: Public Library of Science
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title: Cryptic variation between species and the basis of hybrid performance
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  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
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