---
_id: '4248'
abstract:
- lang: eng
  text: 'In finite populations, genetic drift generates interference between selected
    loci, causing advantageous alleles to be found more often on different chromosomes
    than on the same chromosome, which reduces the rate of adaptation. This “Hill–Robertson
    effect” generates indirect selection to increase recombination rates. We present
    a new method to quantify the strength of this selection. Our model represents
    a new beneficial allele (A) entering a population as a single copy, while another
    beneficial allele (B) is sweeping at another locus. A third locus affects the
    recombination rate between selected loci. Using a branching process model, we
    calculate the probability distribution of the number of copies of A on the different
    genetic backgrounds, after it is established but while it is still rare. Then,
    we use a deterministic model to express the change in frequency of the recombination
    modifier, due to hitchhiking, as A goes to fixation. We show that this method
    can give good estimates of selection for recombination. Moreover, it shows that
    recombination is selected through two different effects: it increases the fixation
    probability of new alleles, and it accelerates selective sweeps. The relative
    importance of these two effects depends on the relative times of occurrence of
    the beneficial alleles.'
author:
- first_name: Denis
  full_name: Roze, Denis
  last_name: Roze
- first_name: Nicholas H
  full_name: Nicholas Barton
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
citation:
  ama: Roze D, Barton NH. The Hill-Robertson effect and the evolution of recombination.
    <i>Genetics</i>. 2006;173(3):1793-1811. doi:<a href="https://doi.org/10.1534/genetics.106.058586
    ">10.1534/genetics.106.058586 </a>
  apa: Roze, D., &#38; Barton, N. H. (2006). The Hill-Robertson effect and the evolution
    of recombination. <i>Genetics</i>. Genetics Society of America. <a href="https://doi.org/10.1534/genetics.106.058586
    ">https://doi.org/10.1534/genetics.106.058586 </a>
  chicago: Roze, Denis, and Nicholas H Barton. “The Hill-Robertson Effect and the
    Evolution of Recombination.” <i>Genetics</i>. Genetics Society of America, 2006.
    <a href="https://doi.org/10.1534/genetics.106.058586 ">https://doi.org/10.1534/genetics.106.058586
    </a>.
  ieee: D. Roze and N. H. Barton, “The Hill-Robertson effect and the evolution of
    recombination,” <i>Genetics</i>, vol. 173, no. 3. Genetics Society of America,
    pp. 1793–1811, 2006.
  ista: Roze D, Barton NH. 2006. The Hill-Robertson effect and the evolution of recombination.
    Genetics. 173(3), 1793–1811.
  mla: Roze, Denis, and Nicholas H. Barton. “The Hill-Robertson Effect and the Evolution
    of Recombination.” <i>Genetics</i>, vol. 173, no. 3, Genetics Society of America,
    2006, pp. 1793–811, doi:<a href="https://doi.org/10.1534/genetics.106.058586 ">10.1534/genetics.106.058586
    </a>.
  short: D. Roze, N.H. Barton, Genetics 173 (2006) 1793–1811.
date_created: 2018-12-11T12:07:50Z
date_published: 2006-07-01T00:00:00Z
date_updated: 2021-01-12T07:55:36Z
day: '01'
doi: '10.1534/genetics.106.058586 '
extern: 1
intvolume: '       173'
issue: '3'
month: '07'
page: 1793 - 1811
publication: Genetics
publication_status: published
publisher: Genetics Society of America
publist_id: '1854'
quality_controlled: 0
status: public
title: The Hill-Robertson effect and the evolution of recombination
type: journal_article
volume: 173
year: '2006'
...
---
_id: '4250'
abstract:
- lang: eng
  text: A recent analysis has shown that divergence between human and chimpanzee varies
    greatly across the genome. Although this is consistent with ‘hybridisation’ between
    the diverging human and chimp lineages, such observations can be explained more
    simply by the null model of allopatric speciation.
author:
- first_name: Nicholas H
  full_name: Nicholas Barton
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
citation:
  ama: 'Barton NH. Evolutionary Biology: How did the human species form? <i>Current
    Biology</i>. 2006;16(16):647-650. doi:<a href="https://doi.org/10.1016/j.cub.2006.07.032">10.1016/j.cub.2006.07.032</a>'
  apa: 'Barton, N. H. (2006). Evolutionary Biology: How did the human species form?
    <i>Current Biology</i>. Cell Press. <a href="https://doi.org/10.1016/j.cub.2006.07.032">https://doi.org/10.1016/j.cub.2006.07.032</a>'
  chicago: 'Barton, Nicholas H. “Evolutionary Biology: How Did the Human Species Form?”
    <i>Current Biology</i>. Cell Press, 2006. <a href="https://doi.org/10.1016/j.cub.2006.07.032">https://doi.org/10.1016/j.cub.2006.07.032</a>.'
  ieee: 'N. H. Barton, “Evolutionary Biology: How did the human species form?,” <i>Current
    Biology</i>, vol. 16, no. 16. Cell Press, pp. 647–650, 2006.'
  ista: 'Barton NH. 2006. Evolutionary Biology: How did the human species form? Current
    Biology. 16(16), 647–650.'
  mla: 'Barton, Nicholas H. “Evolutionary Biology: How Did the Human Species Form?”
    <i>Current Biology</i>, vol. 16, no. 16, Cell Press, 2006, pp. 647–50, doi:<a
    href="https://doi.org/10.1016/j.cub.2006.07.032">10.1016/j.cub.2006.07.032</a>.'
  short: N.H. Barton, Current Biology 16 (2006) 647–650.
date_created: 2018-12-11T12:07:51Z
date_published: 2006-08-22T00:00:00Z
date_updated: 2019-04-26T07:22:41Z
day: '22'
doi: 10.1016/j.cub.2006.07.032
extern: 1
intvolume: '        16'
issue: '16'
month: '08'
page: 647 - 650
publication: Current Biology
publication_status: published
publisher: Cell Press
publist_id: '1850'
quality_controlled: 0
status: public
title: 'Evolutionary Biology: How did the human species form?'
type: review
volume: 16
year: '2006'
...
---
_id: '4345'
abstract:
- lang: eng
  text: Der Artikel beschäftigt sich mit dem Konzept der Bibliothek 2.0 (bzw. Library
    2.0). Er skizziert anhand einiger Beispiele die Entwicklung zum Web 2.0 und beschreibt,
    wie Web 2.0-Technologien und -Anwendungen in Bibliotheken eingesetzt werden. Im
    Mittelpunkt stehen Social-Tagging-Systeme, benutzerorientierte Erweiterungen von
    Bibliothekskatalogen und Dokumentenservern sowie der Einsatz von Weblogs an Bibliotheken.
    Ferner werden neue Anforderungen an Bibliothekare diskutiert.
author:
- first_name: Patrick
  full_name: Patrick Danowski
  id: 2EBD1598-F248-11E8-B48F-1D18A9856A87
  last_name: Danowski
  orcid: 0000-0002-6026-4409
- first_name: Lambert
  full_name: Heller,Lambert
  last_name: Heller
citation:
  ama: Danowski P, Heller L. Bibliothek 2.0 - Die Bibliothek der Zukunft? <i>Bibliotheksdienst</i>.
    2006;40(11):1250-1271. doi:<a href="https://doi.org/424">424</a>
  apa: Danowski, P., &#38; Heller, L. (2006). Bibliothek 2.0 - Die Bibliothek der
    Zukunft? <i>Bibliotheksdienst</i>. Zentral- und Landesbibliothek Berlin. <a href="https://doi.org/424">https://doi.org/424</a>
  chicago: Danowski, Patrick, and Lambert Heller. “Bibliothek 2.0 - Die Bibliothek
    Der Zukunft?” <i>Bibliotheksdienst</i>. Zentral- und Landesbibliothek Berlin,
    2006. <a href="https://doi.org/424">https://doi.org/424</a>.
  ieee: P. Danowski and L. Heller, “Bibliothek 2.0 - Die Bibliothek der Zukunft?,”
    <i>Bibliotheksdienst</i>, vol. 40, no. 11. Zentral- und Landesbibliothek Berlin,
    pp. 1250–1271, 2006.
  ista: Danowski P, Heller L. 2006. Bibliothek 2.0 - Die Bibliothek der Zukunft? Bibliotheksdienst.
    40(11), 1250–1271.
  mla: Danowski, Patrick, and Lambert Heller. “Bibliothek 2.0 - Die Bibliothek Der
    Zukunft?” <i>Bibliotheksdienst</i>, vol. 40, no. 11, Zentral- und Landesbibliothek
    Berlin, 2006, pp. 1250–71, doi:<a href="https://doi.org/424">424</a>.
  short: P. Danowski, L. Heller, Bibliotheksdienst 40 (2006) 1250–1271.
date_created: 2018-12-11T12:08:23Z
date_published: 2006-01-01T00:00:00Z
date_updated: 2021-01-12T07:56:17Z
day: '01'
doi: '424'
extern: 1
intvolume: '        40'
issue: '11'
main_file_link:
- open_access: '0'
  url: http://www.zlb.de/aktivitaeten/bd_neu/heftinhalte2006/DigitaleBib011106.pdf
month: '01'
page: 1250 - 1271
publication: Bibliotheksdienst
publication_status: published
publisher: Zentral- und Landesbibliothek Berlin
publist_id: '1229'
quality_controlled: 0
status: public
title: Bibliothek 2.0 - Die Bibliothek der Zukunft?
type: journal_article
volume: 40
year: '2006'
...
---
_id: '4351'
abstract:
- lang: eng
  text: 'BACKGROUND: Character mapping on phylogenies has played an important, if
    not critical role, in our understanding of molecular, morphological, and behavioral
    evolution. Until very recently we have relied on parsimony to infer character
    changes. Parsimony has a number of serious limitations that are drawbacks to our
    understanding. Recent statistical methods have been developed that free us from
    these limitations enabling us to overcome the problems of parsimony by accommodating
    uncertainty in evolutionary time, ancestral states, and the phylogeny. RESULTS:
    SIMMAP has been developed to implement stochastic character mapping that is useful
    to both molecular evolutionists, systematists, and bioinformaticians. Researchers
    can address questions about positive selection, patterns of amino acid substitution,
    character association, and patterns of morphological evolution. CONCLUSION: Stochastic
    character mapping, as implemented in the SIMMAP software, enables users to address
    questions that require mapping characters onto phylogenies using a probabilistic
    approach that does not rely on parsimony. Analyses can be performed using a fully
    Bayesian approach that is not reliant on considering a single topology, set of
    substitution model parameters, or reconstruction of ancestral states. Uncertainty
    in these quantities is accommodated by using MCMC samples from their respective
    posterior distributions.'
author:
- first_name: Jonathan P
  full_name: Jonathan Bollback
  id: 2C6FA9CC-F248-11E8-B48F-1D18A9856A87
  last_name: Bollback
  orcid: 0000-0002-4624-4612
citation:
  ama: 'Bollback JP. SIMMAP: stochastic character mapping of discrete traits on phylogenies.
    <i>BMC Bioinformatics</i>. 2006;7. doi:<a href="https://doi.org/10.1186/1471-2105-7-88">10.1186/1471-2105-7-88</a>'
  apa: 'Bollback, J. P. (2006). SIMMAP: stochastic character mapping of discrete traits
    on phylogenies. <i>BMC Bioinformatics</i>. BioMed Central. <a href="https://doi.org/10.1186/1471-2105-7-88">https://doi.org/10.1186/1471-2105-7-88</a>'
  chicago: 'Bollback, Jonathan P. “SIMMAP: Stochastic Character Mapping of Discrete
    Traits on Phylogenies.” <i>BMC Bioinformatics</i>. BioMed Central, 2006. <a href="https://doi.org/10.1186/1471-2105-7-88">https://doi.org/10.1186/1471-2105-7-88</a>.'
  ieee: 'J. P. Bollback, “SIMMAP: stochastic character mapping of discrete traits
    on phylogenies,” <i>BMC Bioinformatics</i>, vol. 7. BioMed Central, 2006.'
  ista: 'Bollback JP. 2006. SIMMAP: stochastic character mapping of discrete traits
    on phylogenies. BMC Bioinformatics. 7.'
  mla: 'Bollback, Jonathan P. “SIMMAP: Stochastic Character Mapping of Discrete Traits
    on Phylogenies.” <i>BMC Bioinformatics</i>, vol. 7, BioMed Central, 2006, doi:<a
    href="https://doi.org/10.1186/1471-2105-7-88">10.1186/1471-2105-7-88</a>.'
  short: J.P. Bollback, BMC Bioinformatics 7 (2006).
date_created: 2018-12-11T12:08:25Z
date_published: 2006-01-01T00:00:00Z
date_updated: 2021-01-12T07:56:20Z
day: '01'
doi: 10.1186/1471-2105-7-88
extern: 1
intvolume: '         7'
month: '01'
publication: BMC Bioinformatics
publication_status: published
publisher: BioMed Central
publist_id: '1109'
quality_controlled: 0
status: public
title: 'SIMMAP: stochastic character mapping of discrete traits on phylogenies'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
volume: 7
year: '2006'
...
---
_id: '4352'
abstract:
- lang: eng
  text: 'Anopheles darlingi is the primary malaria vector in Latin America, and is
    especially important in Amazonian Brazil. Historically, control efforts have been
    focused on indoor house spraying using a variety of insecticides, but since the
    mid-1990s there has been a shift to patient treatment and focal insecticide fogging.
    Anopheles darlingi was believed to have been significantly reduced in a gold-mining
    community, Peixoto de Azevedo (in Mato Grosso State), in the early 1990s by insecticide
    use during a severe malaria epidemic. In contrast, although An. darlingi was eradicated
    from some districts of the city of Belem (the capital of Para State) in 1968 to
    reduce malaria, populations around the water protection area in the eastern district
    were treated only briefly. To investigate the population structure of An. darlingi
    including evidence for a population bottleneck in Peixoto, we analyzed eight microsatellite
    loci of 256 individuals from seven locations in Brazil: three in Amapa State,
    three in Para State, and one in Mato Grosso State. Allelic diversity and mean
    expected heterozygosity were high for all populations (mean number alleles/locus
    and H(E) were 13.5 and 0.834, respectively) and did not differ significantly between
    locations. Significant heterozygote deficits were associated with linkage disequilibrium,
    most likely due to either the Wahlund effect or selection. We found no evidence
    for a population bottleneck in Peixoto, possibly because the reduction was not
    extreme enough to be detected. Overall estimates of long-term N(e) varied from
    92.4 individuals under the linkage disequilibrium model to infinity under the
    heterozygote excess model. Fixation indices and analysis of molecular variance
    demonstrated significant differentiation between locations north and south of
    the Amazon River, suggesting a degree of genetic isolation between them, attributed
    to isolation by distance.'
author:
- first_name: Jan
  full_name: Conn, Jan E
  last_name: Conn
- first_name: Joseph
  full_name: Vineis, Joseph H
  last_name: Vineis
- first_name: Jonathan P
  full_name: Jonathan Bollback
  id: 2C6FA9CC-F248-11E8-B48F-1D18A9856A87
  last_name: Bollback
  orcid: 0000-0002-4624-4612
- first_name: David
  full_name: Onyabe, David Y
  last_name: Onyabe
- first_name: Richard
  full_name: Wilkerson, Richard C
  last_name: Wilkerson
- first_name: Marinete
  full_name: Povoa, Marinete M
  last_name: Povoa
citation:
  ama: Conn J, Vineis J, Bollback JP, Onyabe D, Wilkerson R, Povoa M. Population structure
    of the malaria vector Anopheles darlingi in a malaria-endemic region of eastern
    Amazonian Brazil. <i>The American Journal of Tropical Medicine and Hygiene</i>.
    2006;74(5):798-806.
  apa: Conn, J., Vineis, J., Bollback, J. P., Onyabe, D., Wilkerson, R., &#38; Povoa,
    M. (2006). Population structure of the malaria vector Anopheles darlingi in a
    malaria-endemic region of eastern Amazonian Brazil. <i>The American Journal of
    Tropical Medicine and Hygiene</i>. American Society of Tropical Medicine and Hygiene.
  chicago: Conn, Jan, Joseph Vineis, Jonathan P Bollback, David Onyabe, Richard Wilkerson,
    and Marinete Povoa. “Population Structure of the Malaria Vector Anopheles Darlingi
    in a Malaria-Endemic Region of Eastern Amazonian Brazil.” <i>The American Journal
    of Tropical Medicine and Hygiene</i>. American Society of Tropical Medicine and
    Hygiene, 2006.
  ieee: J. Conn, J. Vineis, J. P. Bollback, D. Onyabe, R. Wilkerson, and M. Povoa,
    “Population structure of the malaria vector Anopheles darlingi in a malaria-endemic
    region of eastern Amazonian Brazil,” <i>The American Journal of Tropical Medicine
    and Hygiene</i>, vol. 74, no. 5. American Society of Tropical Medicine and Hygiene,
    pp. 798–806, 2006.
  ista: Conn J, Vineis J, Bollback JP, Onyabe D, Wilkerson R, Povoa M. 2006. Population
    structure of the malaria vector Anopheles darlingi in a malaria-endemic region
    of eastern Amazonian Brazil. The American Journal of Tropical Medicine and Hygiene.
    74(5), 798–806.
  mla: Conn, Jan, et al. “Population Structure of the Malaria Vector Anopheles Darlingi
    in a Malaria-Endemic Region of Eastern Amazonian Brazil.” <i>The American Journal
    of Tropical Medicine and Hygiene</i>, vol. 74, no. 5, American Society of Tropical
    Medicine and Hygiene, 2006, pp. 798–806.
  short: J. Conn, J. Vineis, J.P. Bollback, D. Onyabe, R. Wilkerson, M. Povoa, The
    American Journal of Tropical Medicine and Hygiene 74 (2006) 798–806.
date_created: 2018-12-11T12:08:25Z
date_published: 2006-05-01T00:00:00Z
date_updated: 2021-01-12T07:56:20Z
day: '01'
extern: 1
intvolume: '        74'
issue: '5'
main_file_link:
- open_access: '0'
  url: http://www.ajtmh.org/content/74/5/798.full
month: '05'
page: 798 - 806
publication: The American Journal of Tropical Medicine and Hygiene
publication_status: published
publisher: American Society of Tropical Medicine and Hygiene
publist_id: '1108'
quality_controlled: 0
status: public
title: Population structure of the malaria vector Anopheles darlingi in a malaria-endemic
  region of eastern Amazonian Brazil
type: journal_article
volume: 74
year: '2006'
...
---
_id: '4359'
alternative_title:
- LNCS 3855
author:
- first_name: Thomas
  full_name: Thomas Wies
  id: 447BFB88-F248-11E8-B48F-1D18A9856A87
  last_name: Wies
- first_name: Viktor
  full_name: Kuncak, Viktor
  last_name: Kuncak
- first_name: Patrick
  full_name: Lam,Patrick
  last_name: Lam
- first_name: Andreas
  full_name: Podelski,Andreas
  last_name: Podelski
- first_name: Martin
  full_name: Rinard,Martin
  last_name: Rinard
citation:
  ama: 'Wies T, Kuncak V, Lam P, Podelski A, Rinard M. Field Constraint Analysis.
    In: Springer; 2006:157-173. doi:<a href="https://doi.org/1551">1551</a>'
  apa: 'Wies, T., Kuncak, V., Lam, P., Podelski, A., &#38; Rinard, M. (2006). Field
    Constraint Analysis (pp. 157–173). Presented at the VMCAI: Verification, Model
    Checking and Abstract Interpretation, Springer. <a href="https://doi.org/1551">https://doi.org/1551</a>'
  chicago: Wies, Thomas, Viktor Kuncak, Patrick Lam, Andreas Podelski, and Martin
    Rinard. “Field Constraint Analysis,” 157–73. Springer, 2006. <a href="https://doi.org/1551">https://doi.org/1551</a>.
  ieee: 'T. Wies, V. Kuncak, P. Lam, A. Podelski, and M. Rinard, “Field Constraint
    Analysis,” presented at the VMCAI: Verification, Model Checking and Abstract Interpretation,
    2006, pp. 157–173.'
  ista: 'Wies T, Kuncak V, Lam P, Podelski A, Rinard M. 2006. Field Constraint Analysis.
    VMCAI: Verification, Model Checking and Abstract Interpretation, LNCS 3855, ,
    157–173.'
  mla: Wies, Thomas, et al. <i>Field Constraint Analysis</i>. Springer, 2006, pp.
    157–73, doi:<a href="https://doi.org/1551">1551</a>.
  short: T. Wies, V. Kuncak, P. Lam, A. Podelski, M. Rinard, in:, Springer, 2006,
    pp. 157–173.
conference:
  name: 'VMCAI: Verification, Model Checking and Abstract Interpretation'
date_created: 2018-12-11T12:08:27Z
date_published: 2006-01-01T00:00:00Z
date_updated: 2021-01-12T07:56:23Z
day: '01'
doi: '1551'
extern: 1
month: '01'
page: 157 - 173
publication_status: published
publisher: Springer
publist_id: '1097'
quality_controlled: 0
status: public
title: Field Constraint Analysis
type: conference
year: '2006'
...
---
_id: '4373'
alternative_title:
- LNCS
author:
- first_name: Oded
  full_name: Maler, Oded
  last_name: Maler
- first_name: Dejan
  full_name: Dejan Nickovic
  id: 41BCEE5C-F248-11E8-B48F-1D18A9856A87
  last_name: Nickovic
- first_name: Amir
  full_name: Pnueli,Amir
  last_name: Pnueli
citation:
  ama: 'Maler O, Nickovic D, Pnueli A. Real Time Temporal Logic: Past, Present, Future.
    In: Springer; 2006:2-16. doi:<a href="https://doi.org/1571">1571</a>'
  apa: 'Maler, O., Nickovic, D., &#38; Pnueli, A. (2006). Real Time Temporal Logic:
    Past, Present, Future (pp. 2–16). Presented at the FORMATS: Formal Modeling and
    Analysis of Timed Systems, Springer. <a href="https://doi.org/1571">https://doi.org/1571</a>'
  chicago: 'Maler, Oded, Dejan Nickovic, and Amir Pnueli. “Real Time Temporal Logic:
    Past, Present, Future,” 2–16. Springer, 2006. <a href="https://doi.org/1571">https://doi.org/1571</a>.'
  ieee: 'O. Maler, D. Nickovic, and A. Pnueli, “Real Time Temporal Logic: Past, Present,
    Future,” presented at the FORMATS: Formal Modeling and Analysis of Timed Systems,
    2006, pp. 2–16.'
  ista: 'Maler O, Nickovic D, Pnueli A. 2006. Real Time Temporal Logic: Past, Present,
    Future. FORMATS: Formal Modeling and Analysis of Timed Systems, LNCS, , 2–16.'
  mla: 'Maler, Oded, et al. <i>Real Time Temporal Logic: Past, Present, Future</i>.
    Springer, 2006, pp. 2–16, doi:<a href="https://doi.org/1571">1571</a>.'
  short: O. Maler, D. Nickovic, A. Pnueli, in:, Springer, 2006, pp. 2–16.
conference:
  name: 'FORMATS: Formal Modeling and Analysis of Timed Systems'
date_created: 2018-12-11T12:08:31Z
date_published: 2006-01-23T00:00:00Z
date_updated: 2021-01-12T07:56:29Z
day: '23'
doi: '1571'
extern: 1
month: '01'
page: 2 - 16
publication_status: published
publisher: Springer
publist_id: '1084'
quality_controlled: 0
status: public
title: 'Real Time Temporal Logic: Past, Present, Future'
type: conference
year: '2006'
...
---
_id: '4374'
alternative_title:
- LNCS
author:
- first_name: Oded
  full_name: Maler, Oded
  last_name: Maler
- first_name: Dejan
  full_name: Dejan Nickovic
  id: 41BCEE5C-F248-11E8-B48F-1D18A9856A87
  last_name: Nickovic
- first_name: Amir
  full_name: Pnueli,Amir
  last_name: Pnueli
citation:
  ama: 'Maler O, Nickovic D, Pnueli A. From MITL to Timed Automata. In: Springer;
    2006:274-289. doi:<a href="https://doi.org/1570">1570</a>'
  apa: 'Maler, O., Nickovic, D., &#38; Pnueli, A. (2006). From MITL to Timed Automata
    (pp. 274–289). Presented at the FORMATS: Formal Modeling and Analysis of Timed
    Systems, Springer. <a href="https://doi.org/1570">https://doi.org/1570</a>'
  chicago: Maler, Oded, Dejan Nickovic, and Amir Pnueli. “From MITL to Timed Automata,”
    274–89. Springer, 2006. <a href="https://doi.org/1570">https://doi.org/1570</a>.
  ieee: 'O. Maler, D. Nickovic, and A. Pnueli, “From MITL to Timed Automata,” presented
    at the FORMATS: Formal Modeling and Analysis of Timed Systems, 2006, pp. 274–289.'
  ista: 'Maler O, Nickovic D, Pnueli A. 2006. From MITL to Timed Automata. FORMATS:
    Formal Modeling and Analysis of Timed Systems, LNCS, , 274–289.'
  mla: Maler, Oded, et al. <i>From MITL to Timed Automata</i>. Springer, 2006, pp.
    274–89, doi:<a href="https://doi.org/1570">1570</a>.
  short: O. Maler, D. Nickovic, A. Pnueli, in:, Springer, 2006, pp. 274–289.
conference:
  name: 'FORMATS: Formal Modeling and Analysis of Timed Systems'
date_created: 2018-12-11T12:08:31Z
date_published: 2006-10-19T00:00:00Z
date_updated: 2021-01-12T07:56:30Z
day: '19'
doi: '1570'
extern: 1
month: '10'
page: 274 - 289
publication_status: published
publisher: Springer
publist_id: '1085'
quality_controlled: 0
status: public
title: From MITL to Timed Automata
type: conference
year: '2006'
...
---
_id: '4401'
alternative_title:
- LNCS
author:
- first_name: Rajeev
  full_name: Alur, Rajeev
  last_name: Alur
- first_name: Pavol
  full_name: Pavol Cerny
  id: 4DCBEFFE-F248-11E8-B48F-1D18A9856A87
  last_name: Cerny
- first_name: Steve
  full_name: Zdancewic,Steve
  last_name: Zdancewic
citation:
  ama: 'Alur R, Cerny P, Zdancewic S. Preserving Secrecy Under Refinement. In: Springer;
    2006:107-118. doi:<a href="https://doi.org/1543">1543</a>'
  apa: 'Alur, R., Cerny, P., &#38; Zdancewic, S. (2006). Preserving Secrecy Under
    Refinement (pp. 107–118). Presented at the ICALP: Automata, Languages and Programming,
    Springer. <a href="https://doi.org/1543">https://doi.org/1543</a>'
  chicago: Alur, Rajeev, Pavol Cerny, and Steve Zdancewic. “Preserving Secrecy Under
    Refinement,” 107–18. Springer, 2006. <a href="https://doi.org/1543">https://doi.org/1543</a>.
  ieee: 'R. Alur, P. Cerny, and S. Zdancewic, “Preserving Secrecy Under Refinement,”
    presented at the ICALP: Automata, Languages and Programming, 2006, pp. 107–118.'
  ista: 'Alur R, Cerny P, Zdancewic S. 2006. Preserving Secrecy Under Refinement.
    ICALP: Automata, Languages and Programming, LNCS, , 107–118.'
  mla: Alur, Rajeev, et al. <i>Preserving Secrecy Under Refinement</i>. Springer,
    2006, pp. 107–18, doi:<a href="https://doi.org/1543">1543</a>.
  short: R. Alur, P. Cerny, S. Zdancewic, in:, Springer, 2006, pp. 107–118.
conference:
  name: 'ICALP: Automata, Languages and Programming'
date_created: 2018-12-11T12:08:40Z
date_published: 2006-01-01T00:00:00Z
date_updated: 2021-01-12T07:56:42Z
day: '01'
doi: '1543'
extern: 1
month: '01'
page: 107 - 118
publication_status: published
publisher: Springer
publist_id: '1054'
quality_controlled: 0
status: public
title: Preserving Secrecy Under Refinement
type: conference
year: '2006'
...
---
_id: '4406'
abstract:
- lang: eng
  text: We propose and evaluate a new algorithm for checking the universality of nondeterministic
    finite automata. In contrast to the standard algorithm, which uses the subset
    construction to explicitly determinize the automaton, we keep the determinization
    step implicit. Our algorithm computes the least fixed point of a monotone function
    on the lattice of antichains of state sets. We evaluate the performance of our
    algorithm experimentally using the random automaton model recently proposed by
    Tabakov and Vardi. We show that on the difficult instances of this probabilistic
    model, the antichain algorithm outperforms the standard one by several orders
    of magnitude. We also show how variations of the antichain method can be used
    for solving the language-inclusion problem for nondeterministic finite automata,
    and the emptiness problem for alternating finite automata.
acknowledgement: This research was supported in part by the NSF grants CCR-0234690
  and CCR-0225610, and the Belgian FNRS grant 2.4530.02 of the FRFC project “Centre
  Fédéré en Vérification.”
alternative_title:
- LNCS
author:
- first_name: Martin
  full_name: De Wulf, Martin
  last_name: De Wulf
- first_name: Laurent
  full_name: Doyen, Laurent
  last_name: Doyen
- first_name: Thomas A
  full_name: Thomas Henzinger
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
- first_name: Jean
  full_name: Raskin, Jean-François
  last_name: Raskin
citation:
  ama: 'De Wulf M, Doyen L, Henzinger TA, Raskin J. Antichains: A new algorithm for
    checking universality of finite automata. In: Vol 4144. Springer; 2006:17-30.
    doi:<a href="https://doi.org/10.1007/11817963_5">10.1007/11817963_5</a>'
  apa: 'De Wulf, M., Doyen, L., Henzinger, T. A., &#38; Raskin, J. (2006). Antichains:
    A new algorithm for checking universality of finite automata (Vol. 4144, pp. 17–30).
    Presented at the CAV: Computer Aided Verification, Springer. <a href="https://doi.org/10.1007/11817963_5">https://doi.org/10.1007/11817963_5</a>'
  chicago: 'De Wulf, Martin, Laurent Doyen, Thomas A Henzinger, and Jean Raskin. “Antichains:
    A New Algorithm for Checking Universality of Finite Automata,” 4144:17–30. Springer,
    2006. <a href="https://doi.org/10.1007/11817963_5">https://doi.org/10.1007/11817963_5</a>.'
  ieee: 'M. De Wulf, L. Doyen, T. A. Henzinger, and J. Raskin, “Antichains: A new
    algorithm for checking universality of finite automata,” presented at the CAV:
    Computer Aided Verification, 2006, vol. 4144, pp. 17–30.'
  ista: 'De Wulf M, Doyen L, Henzinger TA, Raskin J. 2006. Antichains: A new algorithm
    for checking universality of finite automata. CAV: Computer Aided Verification,
    LNCS, vol. 4144, 17–30.'
  mla: 'De Wulf, Martin, et al. <i>Antichains: A New Algorithm for Checking Universality
    of Finite Automata</i>. Vol. 4144, Springer, 2006, pp. 17–30, doi:<a href="https://doi.org/10.1007/11817963_5">10.1007/11817963_5</a>.'
  short: M. De Wulf, L. Doyen, T.A. Henzinger, J. Raskin, in:, Springer, 2006, pp.
    17–30.
conference:
  name: 'CAV: Computer Aided Verification'
date_created: 2018-12-11T12:08:41Z
date_published: 2006-08-08T00:00:00Z
date_updated: 2021-01-12T07:56:45Z
day: '08'
doi: 10.1007/11817963_5
extern: 1
intvolume: '      4144'
month: '08'
page: 17 - 30
publication_status: published
publisher: Springer
publist_id: '326'
quality_controlled: 0
status: public
title: 'Antichains: A new algorithm for checking universality of finite automata'
type: conference
volume: 4144
year: '2006'
...
---
_id: '4431'
abstract:
- lang: eng
  text: 'We summarize some current trends in embedded systems design and point out
    some of their characteristics, such as the chasm between analytical and computational
    models, and the gap between safety-critical and best-effort engineering practices.
    We call for a coherent scientific foundation for embedded systems design, and
    we discuss a few key demands on such a foundation: the need for encompassing several
    manifestations of heterogeneity, and the need for constructivity in design. We
    believe that the development of a satisfactory Embedded Systems Design Science
    provides a timely challenge and opportunity for reinvigorating computer science.'
acknowledgement: Supported in part by the ARTIST2 European Network of Excellence on
  Embedded Systems Design, by the NSF ITR Center on Hybrid and Embedded Software Systems
  (CHESS), and by the SNSF NCCR on Mobile Information and Communication Systems (MICS).
alternative_title:
- LNCS
author:
- first_name: Thomas A
  full_name: Thomas Henzinger
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
- first_name: Joseph
  full_name: Sifakis, Joseph
  last_name: Sifakis
citation:
  ama: 'Henzinger TA, Sifakis J. The embedded systems design challenge. In: Vol 4085.
    Springer; 2006:1-15. doi:<a href="https://doi.org/10.1007/11813040_1">10.1007/11813040_1</a>'
  apa: 'Henzinger, T. A., &#38; Sifakis, J. (2006). The embedded systems design challenge
    (Vol. 4085, pp. 1–15). Presented at the FM: Formal Methods, Springer. <a href="https://doi.org/10.1007/11813040_1">https://doi.org/10.1007/11813040_1</a>'
  chicago: Henzinger, Thomas A, and Joseph Sifakis. “The Embedded Systems Design Challenge,”
    4085:1–15. Springer, 2006. <a href="https://doi.org/10.1007/11813040_1">https://doi.org/10.1007/11813040_1</a>.
  ieee: 'T. A. Henzinger and J. Sifakis, “The embedded systems design challenge,”
    presented at the FM: Formal Methods, 2006, vol. 4085, pp. 1–15.'
  ista: 'Henzinger TA, Sifakis J. 2006. The embedded systems design challenge. FM:
    Formal Methods, LNCS, vol. 4085, 1–15.'
  mla: Henzinger, Thomas A., and Joseph Sifakis. <i>The Embedded Systems Design Challenge</i>.
    Vol. 4085, Springer, 2006, pp. 1–15, doi:<a href="https://doi.org/10.1007/11813040_1">10.1007/11813040_1</a>.
  short: T.A. Henzinger, J. Sifakis, in:, Springer, 2006, pp. 1–15.
conference:
  name: 'FM: Formal Methods'
date_created: 2018-12-11T12:08:49Z
date_published: 2006-08-10T00:00:00Z
date_updated: 2021-01-12T07:56:55Z
day: '10'
doi: 10.1007/11813040_1
extern: 1
intvolume: '      4085'
month: '08'
page: 1 - 15
publication_status: published
publisher: Springer
publist_id: '301'
quality_controlled: 0
status: public
title: The embedded systems design challenge
type: conference
volume: 4085
year: '2006'
...
---
_id: '4432'
abstract:
- lang: eng
  text: We add freeze quantifiers to the game logic ATL in order to specify real-time
    objectives for games played on timed structures. We define the semantics of the
    resulting logic TATL by restricting the players to physically meaningful strategies,
    which do not prevent time from diverging. We show that TATL can be model checked
    over timed automaton games. We also specify timed optimization problems for physically
    meaningful strategies, and we show that for timed automaton games, the optimal
    answers can be approximated to within any degree of precision.
acknowledgement: This research was supported in part by the NSF grants CCR-0208875,
  CCR-0225610, and CCR-0234690.
alternative_title:
- LNCS
author:
- first_name: Thomas A
  full_name: Thomas Henzinger
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
- first_name: Vinayak
  full_name: Prabhu, Vinayak S
  last_name: Prabhu
citation:
  ama: 'Henzinger TA, Prabhu V. Timed alternating-time temporal logic. In: Vol 4202.
    Springer; 2006:1-17. doi:<a href="https://doi.org/10.1007/11867340_1">10.1007/11867340_1</a>'
  apa: 'Henzinger, T. A., &#38; Prabhu, V. (2006). Timed alternating-time temporal
    logic (Vol. 4202, pp. 1–17). Presented at the FORMATS: Formal Modeling and Analysis
    of Timed Systems, Springer. <a href="https://doi.org/10.1007/11867340_1">https://doi.org/10.1007/11867340_1</a>'
  chicago: Henzinger, Thomas A, and Vinayak Prabhu. “Timed Alternating-Time Temporal
    Logic,” 4202:1–17. Springer, 2006. <a href="https://doi.org/10.1007/11867340_1">https://doi.org/10.1007/11867340_1</a>.
  ieee: 'T. A. Henzinger and V. Prabhu, “Timed alternating-time temporal logic,” presented
    at the FORMATS: Formal Modeling and Analysis of Timed Systems, 2006, vol. 4202,
    pp. 1–17.'
  ista: 'Henzinger TA, Prabhu V. 2006. Timed alternating-time temporal logic. FORMATS:
    Formal Modeling and Analysis of Timed Systems, LNCS, vol. 4202, 1–17.'
  mla: Henzinger, Thomas A., and Vinayak Prabhu. <i>Timed Alternating-Time Temporal
    Logic</i>. Vol. 4202, Springer, 2006, pp. 1–17, doi:<a href="https://doi.org/10.1007/11867340_1">10.1007/11867340_1</a>.
  short: T.A. Henzinger, V. Prabhu, in:, Springer, 2006, pp. 1–17.
conference:
  name: 'FORMATS: Formal Modeling and Analysis of Timed Systems'
date_created: 2018-12-11T12:08:49Z
date_published: 2006-09-19T00:00:00Z
date_updated: 2021-01-12T07:56:56Z
day: '19'
doi: 10.1007/11867340_1
extern: 1
intvolume: '      4202'
month: '09'
page: 1 - 17
publication_status: published
publisher: Springer
publist_id: '296'
quality_controlled: 0
status: public
title: Timed alternating-time temporal logic
type: conference
volume: 4202
year: '2006'
...
---
_id: '4436'
abstract:
- lang: eng
  text: We present an assume-guarantee interface algebra for real-time components.
    In our formalism a component implements a set of task sequences that share a resource.
    A component interface consists of an arrival rate function and a latency for each
    task sequence, and a capacity function for the shared resource. The interface
    specifies that the component guarantees certain task latencies depending on assumptions
    about task arrival rates and allocated resource capacities. Our algebra defines
    compatibility and refinement relations on interfaces. Interface compatibility
    can be checked on partial designs, even when some component interfaces are yet
    unknown. In this case interface composition computes as new assumptions the weakest
    constraints on the unknown components that are necessary to satisfy the specified
    guarantees. Interface refinement is defined in a way that ensures that compatible
    interfaces can be refined and implemented independently. Our algebra thus formalizes
    an interface-based design methodology that supports both the incremental addition
    of new components and the independent stepwise refinement of existing components.
    We demonstrate the flexibility and efficiency of the framework through simulation
    experiments.
author:
- first_name: Thomas A
  full_name: Thomas Henzinger
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
- first_name: Slobodan
  full_name: Matic, Slobodan
  last_name: Matic
citation:
  ama: 'Henzinger TA, Matic S. An interface algebra for real-time components. In:
    IEEE; 2006:253-266. doi:<a href="https://doi.org/10.1109/RTAS.2006.11">10.1109/RTAS.2006.11</a>'
  apa: 'Henzinger, T. A., &#38; Matic, S. (2006). An interface algebra for real-time
    components (pp. 253–266). Presented at the RTAS: Real-time and Embedded Technology
    and Applications Symposium, IEEE. <a href="https://doi.org/10.1109/RTAS.2006.11">https://doi.org/10.1109/RTAS.2006.11</a>'
  chicago: Henzinger, Thomas A, and Slobodan Matic. “An Interface Algebra for Real-Time
    Components,” 253–66. IEEE, 2006. <a href="https://doi.org/10.1109/RTAS.2006.11">https://doi.org/10.1109/RTAS.2006.11</a>.
  ieee: 'T. A. Henzinger and S. Matic, “An interface algebra for real-time components,”
    presented at the RTAS: Real-time and Embedded Technology and Applications Symposium,
    2006, pp. 253–266.'
  ista: 'Henzinger TA, Matic S. 2006. An interface algebra for real-time components.
    RTAS: Real-time and Embedded Technology and Applications Symposium, 253–266.'
  mla: Henzinger, Thomas A., and Slobodan Matic. <i>An Interface Algebra for Real-Time
    Components</i>. IEEE, 2006, pp. 253–66, doi:<a href="https://doi.org/10.1109/RTAS.2006.11">10.1109/RTAS.2006.11</a>.
  short: T.A. Henzinger, S. Matic, in:, IEEE, 2006, pp. 253–266.
conference:
  name: 'RTAS: Real-time and Embedded Technology and Applications Symposium'
date_created: 2018-12-11T12:08:50Z
date_published: 2006-04-24T00:00:00Z
date_updated: 2021-01-12T07:56:57Z
day: '24'
doi: 10.1109/RTAS.2006.11
extern: 1
month: '04'
page: 253 - 266
publication_status: published
publisher: IEEE
publist_id: '294'
quality_controlled: 0
status: public
title: An interface algebra for real-time components
type: conference
year: '2006'
...
---
_id: '4437'
abstract:
- lang: eng
  text: The synthesis of reactive systems requires the solution of two-player games
    on graphs with ω-regular objectives. When the objective is specified by a linear
    temporal logic formula or nondeterministic Büchi automaton, then previous algorithms
    for solving the game require the construction of an equivalent deterministic automaton.
    However, determinization for automata on infinite words is extremely complicated,
    and current implementations fail to produce deterministic automata even for relatively
    small inputs. We show how to construct, from a given nondeterministic Büchi automaton,
    an equivalent nondeterministic parity automaton that is good for solving games
    with objective . The main insight is that a nondeterministic automaton is good
    for solving games if it fairly simulates the equivalent deterministic automaton.
    In this way, we omit the determinization step in game solving and reactive synthesis.
    The fact that our automata are nondeterministic makes them surprisingly simple,
    amenable to symbolic implementation, and allows an incremental search for winning
    strategies.
acknowledgement: This research was supported in part by the Swiss National Science
  Foundation.
alternative_title:
- LNCS
author:
- first_name: Thomas A
  full_name: Thomas Henzinger
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
- first_name: Nir
  full_name: Piterman, Nir
  last_name: Piterman
citation:
  ama: 'Henzinger TA, Piterman N. Solving games without determinization. In: Vol 4207.
    Springer; 2006:395-410. doi:<a href="https://doi.org/10.1007/11874683_26">10.1007/11874683_26</a>'
  apa: 'Henzinger, T. A., &#38; Piterman, N. (2006). Solving games without determinization
    (Vol. 4207, pp. 395–410). Presented at the CSL: Computer Science Logic, Springer.
    <a href="https://doi.org/10.1007/11874683_26">https://doi.org/10.1007/11874683_26</a>'
  chicago: Henzinger, Thomas A, and Nir Piterman. “Solving Games without Determinization,”
    4207:395–410. Springer, 2006. <a href="https://doi.org/10.1007/11874683_26">https://doi.org/10.1007/11874683_26</a>.
  ieee: 'T. A. Henzinger and N. Piterman, “Solving games without determinization,”
    presented at the CSL: Computer Science Logic, 2006, vol. 4207, pp. 395–410.'
  ista: 'Henzinger TA, Piterman N. 2006. Solving games without determinization. CSL:
    Computer Science Logic, LNCS, vol. 4207, 395–410.'
  mla: Henzinger, Thomas A., and Nir Piterman. <i>Solving Games without Determinization</i>.
    Vol. 4207, Springer, 2006, pp. 395–410, doi:<a href="https://doi.org/10.1007/11874683_26">10.1007/11874683_26</a>.
  short: T.A. Henzinger, N. Piterman, in:, Springer, 2006, pp. 395–410.
conference:
  name: 'CSL: Computer Science Logic'
date_created: 2018-12-11T12:08:51Z
date_published: 2006-09-20T00:00:00Z
date_updated: 2021-01-12T07:56:58Z
day: '20'
doi: 10.1007/11874683_26
extern: 1
intvolume: '      4207'
month: '09'
page: 395 - 410
publication_status: published
publisher: Springer
publist_id: '295'
quality_controlled: 0
status: public
title: Solving games without determinization
type: conference
volume: 4207
year: '2006'
...
---
_id: '4451'
abstract:
- lang: eng
  text: One source of complexity in the μ-calculus is its ability to specify an unbounded
    number of switches between universal (AX) and existential (EX) branching modes.
    We therefore study the problems of satisfiability, validity, model checking, and
    implication for the universal and existential fragments of the μ-calculus, in
    which only one branching mode is allowed. The universal fragment is rich enough
    to express most specifications of interest, and therefore improved algorithms
    are of practical importance. We show that while the satisfiability and validity
    problems become indeed simpler for the existential and universal fragments, this
    is, unfortunately, not the case for model checking and implication. We also show
    the corresponding results for the alternation-free fragment of the μ-calculus,
    where no alternations between least and greatest fixed points are allowed. Our
    results imply that efforts to find a polynomial-time model-checking algorithm
    for the μ-calculus can be replaced by efforts to find such an algorithm for the
    universal or existential fragment.
author:
- first_name: Thomas A
  full_name: Thomas Henzinger
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
- first_name: Orna
  full_name: Kupferman, Orna
  last_name: Kupferman
- first_name: Ritankar
  full_name: Majumdar, Ritankar S
  last_name: Majumdar
citation:
  ama: Henzinger TA, Kupferman O, Majumdar R. On the universal and existential fragments
    of the mu-calculus. <i>Theoretical Computer Science</i>. 2006;354(2):173-186.
    doi:<a href="https://doi.org/10.1016/j.tcs.2005.11.015">10.1016/j.tcs.2005.11.015</a>
  apa: Henzinger, T. A., Kupferman, O., &#38; Majumdar, R. (2006). On the universal
    and existential fragments of the mu-calculus. <i>Theoretical Computer Science</i>.
    Elsevier. <a href="https://doi.org/10.1016/j.tcs.2005.11.015">https://doi.org/10.1016/j.tcs.2005.11.015</a>
  chicago: Henzinger, Thomas A, Orna Kupferman, and Ritankar Majumdar. “On the Universal
    and Existential Fragments of the Mu-Calculus.” <i>Theoretical Computer Science</i>.
    Elsevier, 2006. <a href="https://doi.org/10.1016/j.tcs.2005.11.015">https://doi.org/10.1016/j.tcs.2005.11.015</a>.
  ieee: T. A. Henzinger, O. Kupferman, and R. Majumdar, “On the universal and existential
    fragments of the mu-calculus,” <i>Theoretical Computer Science</i>, vol. 354,
    no. 2. Elsevier, pp. 173–186, 2006.
  ista: Henzinger TA, Kupferman O, Majumdar R. 2006. On the universal and existential
    fragments of the mu-calculus. Theoretical Computer Science. 354(2), 173–186.
  mla: Henzinger, Thomas A., et al. “On the Universal and Existential Fragments of
    the Mu-Calculus.” <i>Theoretical Computer Science</i>, vol. 354, no. 2, Elsevier,
    2006, pp. 173–86, doi:<a href="https://doi.org/10.1016/j.tcs.2005.11.015">10.1016/j.tcs.2005.11.015</a>.
  short: T.A. Henzinger, O. Kupferman, R. Majumdar, Theoretical Computer Science 354
    (2006) 173–186.
date_created: 2018-12-11T12:08:55Z
date_published: 2006-03-28T00:00:00Z
date_updated: 2021-01-12T07:57:04Z
day: '28'
doi: 10.1016/j.tcs.2005.11.015
extern: 1
intvolume: '       354'
issue: '2'
month: '03'
page: 173 - 186
publication: Theoretical Computer Science
publication_status: published
publisher: Elsevier
publist_id: '276'
quality_controlled: 0
status: public
title: On the universal and existential fragments of the mu-calculus
type: journal_article
volume: 354
year: '2006'
...
---
_id: '4523'
abstract:
- lang: eng
  text: We consider the problem if a given program satisfies a specified safety property.
    Interesting programs have infinite state spaces, with inputs ranging over infinite
    domains, and for these programs the property checking problem is undecidable.
    Two broad approaches to property checking are testing and verification. Testing
    tries to find inputs and executions which demonstrate violations of the property.
    Verification tries to construct a formal proof which shows that all executions
    of the program satisfy the property. Testing works best when errors are easy to
    find, but it is often difficult to achieve sufficient coverage for correct programs.
    On the other hand, verification methods are most successful when proofs are easy
    to find, but they are often inefficient at discovering errors. We propose a new
    algorithm, Synergy, which combines testing and verification. Synergy unifies several
    ideas from the literature, including counterexample-guided model checking, directed
    testing, and partition refinement.This paper presents a description of the Synergy
    algorithm, its theoretical properties, a comparison with related algorithms, and
    a prototype implementation called Yogi.
author:
- first_name: Bhargav
  full_name: Gulavani, Bhargav S
  last_name: Gulavani
- first_name: Thomas A
  full_name: Thomas Henzinger
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
- first_name: Yamini
  full_name: Kannan, Yamini
  last_name: Kannan
- first_name: Aditya
  full_name: Nori, Aditya V
  last_name: Nori
- first_name: Sriram
  full_name: Rajamani, Sriram K
  last_name: Rajamani
citation:
  ama: 'Gulavani B, Henzinger TA, Kannan Y, Nori A, Rajamani S. Synergy: A new algorithm
    for property checking. In: ACM; 2006:117-127. doi:<a href="https://doi.org/10.1145/1181775.1181790">10.1145/1181775.1181790</a>'
  apa: 'Gulavani, B., Henzinger, T. A., Kannan, Y., Nori, A., &#38; Rajamani, S. (2006).
    Synergy: A new algorithm for property checking (pp. 117–127). Presented at the
    FSE: Foundations of Software Engineering, ACM. <a href="https://doi.org/10.1145/1181775.1181790">https://doi.org/10.1145/1181775.1181790</a>'
  chicago: 'Gulavani, Bhargav, Thomas A Henzinger, Yamini Kannan, Aditya Nori, and
    Sriram Rajamani. “Synergy: A New Algorithm for Property Checking,” 117–27. ACM,
    2006. <a href="https://doi.org/10.1145/1181775.1181790">https://doi.org/10.1145/1181775.1181790</a>.'
  ieee: 'B. Gulavani, T. A. Henzinger, Y. Kannan, A. Nori, and S. Rajamani, “Synergy:
    A new algorithm for property checking,” presented at the FSE: Foundations of Software
    Engineering, 2006, pp. 117–127.'
  ista: 'Gulavani B, Henzinger TA, Kannan Y, Nori A, Rajamani S. 2006. Synergy: A
    new algorithm for property checking. FSE: Foundations of Software Engineering,
    117–127.'
  mla: 'Gulavani, Bhargav, et al. <i>Synergy: A New Algorithm for Property Checking</i>.
    ACM, 2006, pp. 117–27, doi:<a href="https://doi.org/10.1145/1181775.1181790">10.1145/1181775.1181790</a>.'
  short: B. Gulavani, T.A. Henzinger, Y. Kannan, A. Nori, S. Rajamani, in:, ACM, 2006,
    pp. 117–127.
conference:
  name: 'FSE: Foundations of Software Engineering'
date_created: 2018-12-11T12:09:18Z
date_published: 2006-01-01T00:00:00Z
date_updated: 2021-01-12T07:59:26Z
day: '01'
doi: 10.1145/1181775.1181790
extern: 1
month: '01'
page: 117 - 127
publication_status: published
publisher: ACM
publist_id: '206'
quality_controlled: 0
status: public
title: 'Synergy: A new algorithm for property checking'
type: conference
year: '2006'
...
---
_id: '4526'
abstract:
- lang: eng
  text: 'We designed and implemented a new programming language called Hierarchical
    Timing Language (HTL) for hard realtime systems. Critical timing constraints are
    specified within the language,and ensured by the compiler. Programs in HTL are
    extensible in two dimensions without changing their timing behavior: new program
    modules can be added, and individual program tasks can be refined. The mechanism
    supporting time invariance under parallel composition is that different program
    modules communicate at specified instances of time. Time invariance under refinement
    is achieved by conservative scheduling of the top level. HTL is a coordination
    language, in that individual tasks can be implemented in &quot;foreign&quot; languages.
    As a case study, we present a distributed HTL implementation of an automotive
    steer-by-wire controller.'
author:
- first_name: Arkadeb
  full_name: Ghosal, Arkadeb
  last_name: Ghosal
- first_name: Thomas A
  full_name: Thomas Henzinger
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
- first_name: Daniel
  full_name: Iercan, Daniel
  last_name: Iercan
- first_name: Christoph
  full_name: Kirsch, Christoph M
  last_name: Kirsch
- first_name: Alberto
  full_name: Sangiovanni-Vincentelli, Alberto
  last_name: Sangiovanni Vincentelli
citation:
  ama: 'Ghosal A, Henzinger TA, Iercan D, Kirsch C, Sangiovanni Vincentelli A. A hierarchical
    coordination language for interacting real-time tasks. In: ACM; 2006:132-141.
    doi:<a href="https://doi.org/10.1145/1176887.1176907">10.1145/1176887.1176907</a>'
  apa: 'Ghosal, A., Henzinger, T. A., Iercan, D., Kirsch, C., &#38; Sangiovanni Vincentelli,
    A. (2006). A hierarchical coordination language for interacting real-time tasks
    (pp. 132–141). Presented at the EMSOFT: Embedded Software , ACM. <a href="https://doi.org/10.1145/1176887.1176907">https://doi.org/10.1145/1176887.1176907</a>'
  chicago: Ghosal, Arkadeb, Thomas A Henzinger, Daniel Iercan, Christoph Kirsch, and
    Alberto Sangiovanni Vincentelli. “A Hierarchical Coordination Language for Interacting
    Real-Time Tasks,” 132–41. ACM, 2006. <a href="https://doi.org/10.1145/1176887.1176907">https://doi.org/10.1145/1176887.1176907</a>.
  ieee: 'A. Ghosal, T. A. Henzinger, D. Iercan, C. Kirsch, and A. Sangiovanni Vincentelli,
    “A hierarchical coordination language for interacting real-time tasks,” presented
    at the EMSOFT: Embedded Software , 2006, pp. 132–141.'
  ista: 'Ghosal A, Henzinger TA, Iercan D, Kirsch C, Sangiovanni Vincentelli A. 2006.
    A hierarchical coordination language for interacting real-time tasks. EMSOFT:
    Embedded Software , 132–141.'
  mla: Ghosal, Arkadeb, et al. <i>A Hierarchical Coordination Language for Interacting
    Real-Time Tasks</i>. ACM, 2006, pp. 132–41, doi:<a href="https://doi.org/10.1145/1176887.1176907">10.1145/1176887.1176907</a>.
  short: A. Ghosal, T.A. Henzinger, D. Iercan, C. Kirsch, A. Sangiovanni Vincentelli,
    in:, ACM, 2006, pp. 132–141.
conference:
  name: 'EMSOFT: Embedded Software '
date_created: 2018-12-11T12:09:18Z
date_published: 2006-01-01T00:00:00Z
date_updated: 2021-01-12T07:59:27Z
day: '01'
doi: 10.1145/1176887.1176907
extern: 1
month: '01'
page: 132 - 141
publication_status: published
publisher: ACM
publist_id: '201'
quality_controlled: 0
status: public
title: A hierarchical coordination language for interacting real-time tasks
type: conference
year: '2006'
...
---
_id: '4528'
abstract:
- lang: eng
  text: Computational modeling of biological systems is becoming increasingly common
    as scientists attempt to understand biological phenomena in their full complexity.
    Here we distinguish between two types of biological models mathematical and computational
    - according to their different representations of biological phenomena and their
    diverse potential. We call the approach of constructing computational models of
    biological systems executable biology, as it focuses on the design of executable
    computer algorithms that mimic biological phenomena. We give an overview of the
    main modeling efforts in this direction, and discuss some of the new challenges
    that executable biology poses for computer science and biology. We argue that
    for executable biology to reach its full potential as a mainstream biological
    technique, formal and algorithmic approaches must be integrated into biological
    research, driving biology towards a more precise engineering discipline.
author:
- first_name: Jasmin
  full_name: Fisher, Jasmin
  last_name: Fisher
- first_name: Thomas A
  full_name: Thomas Henzinger
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
citation:
  ama: 'Fisher J, Henzinger TA. Executable biology. In: IEEE; 2006:1675-1682. doi:<a
    href="https://doi.org/10.1109/WSC.2006.322942">10.1109/WSC.2006.322942</a>'
  apa: 'Fisher, J., &#38; Henzinger, T. A. (2006). Executable biology (pp. 1675–1682).
    Presented at the WSC: Winter Simulation Conference, IEEE. <a href="https://doi.org/10.1109/WSC.2006.322942">https://doi.org/10.1109/WSC.2006.322942</a>'
  chicago: Fisher, Jasmin, and Thomas A Henzinger. “Executable Biology,” 1675–82.
    IEEE, 2006. <a href="https://doi.org/10.1109/WSC.2006.322942">https://doi.org/10.1109/WSC.2006.322942</a>.
  ieee: 'J. Fisher and T. A. Henzinger, “Executable biology,” presented at the WSC:
    Winter Simulation Conference, 2006, pp. 1675–1682.'
  ista: 'Fisher J, Henzinger TA. 2006. Executable biology. WSC: Winter Simulation
    Conference, 1675–1682.'
  mla: Fisher, Jasmin, and Thomas A. Henzinger. <i>Executable Biology</i>. IEEE, 2006,
    pp. 1675–82, doi:<a href="https://doi.org/10.1109/WSC.2006.322942">10.1109/WSC.2006.322942</a>.
  short: J. Fisher, T.A. Henzinger, in:, IEEE, 2006, pp. 1675–1682.
conference:
  name: 'WSC: Winter Simulation Conference'
date_created: 2018-12-11T12:09:19Z
date_published: 2006-12-03T00:00:00Z
date_updated: 2021-01-12T07:59:28Z
day: '03'
doi: 10.1109/WSC.2006.322942
extern: 1
month: '12'
page: 1675 - 1682
publication_status: published
publisher: IEEE
publist_id: '197'
quality_controlled: 0
status: public
title: Executable biology
type: conference
year: '2006'
...
---
_id: '4538'
abstract:
- lang: eng
  text: A stochastic graph game is played by two players on a game graph with probabilistic
    transitions. We consider stochastic graph games with ω-regular winning conditions
    specified as parity objectives. These games lie in NP ∩ coNP. We present a strategy
    improvement algorithm for stochastic parity games; this is the first non-brute-force
    algorithm for solving these games. From the strategy improvement algorithm we
    obtain a randomized subexponential-time algorithm to solve such games.
alternative_title:
- LNCS
author:
- first_name: Krishnendu
  full_name: Krishnendu Chatterjee
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Thomas A
  full_name: Thomas Henzinger
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
citation:
  ama: 'Chatterjee K, Henzinger TA. Strategy improvement and randomized subexponential
    algorithms for stochastic parity games. In: Vol 3884. Springer; 2006:512-523.
    doi:<a href="https://doi.org/10.1007/11672142_42">10.1007/11672142_42</a>'
  apa: 'Chatterjee, K., &#38; Henzinger, T. A. (2006). Strategy improvement and randomized
    subexponential algorithms for stochastic parity games (Vol. 3884, pp. 512–523).
    Presented at the STACS: Theoretical Aspects of Computer Science, Springer. <a
    href="https://doi.org/10.1007/11672142_42">https://doi.org/10.1007/11672142_42</a>'
  chicago: Chatterjee, Krishnendu, and Thomas A Henzinger. “Strategy Improvement and
    Randomized Subexponential Algorithms for Stochastic Parity Games,” 3884:512–23.
    Springer, 2006. <a href="https://doi.org/10.1007/11672142_42">https://doi.org/10.1007/11672142_42</a>.
  ieee: 'K. Chatterjee and T. A. Henzinger, “Strategy improvement and randomized subexponential
    algorithms for stochastic parity games,” presented at the STACS: Theoretical Aspects
    of Computer Science, 2006, vol. 3884, pp. 512–523.'
  ista: 'Chatterjee K, Henzinger TA. 2006. Strategy improvement and randomized subexponential
    algorithms for stochastic parity games. STACS: Theoretical Aspects of Computer
    Science, LNCS, vol. 3884, 512–523.'
  mla: Chatterjee, Krishnendu, and Thomas A. Henzinger. <i>Strategy Improvement and
    Randomized Subexponential Algorithms for Stochastic Parity Games</i>. Vol. 3884,
    Springer, 2006, pp. 512–23, doi:<a href="https://doi.org/10.1007/11672142_42">10.1007/11672142_42</a>.
  short: K. Chatterjee, T.A. Henzinger, in:, Springer, 2006, pp. 512–523.
conference:
  name: 'STACS: Theoretical Aspects of Computer Science'
date_created: 2018-12-11T12:09:22Z
date_published: 2006-02-14T00:00:00Z
date_updated: 2021-01-12T07:59:32Z
day: '14'
doi: 10.1007/11672142_42
extern: 1
intvolume: '      3884'
month: '02'
page: 512 - 523
publication_status: published
publisher: Springer
publist_id: '184'
quality_controlled: 0
status: public
title: Strategy improvement and randomized subexponential algorithms for stochastic
  parity games
type: conference
volume: 3884
year: '2006'
...
---
_id: '4539'
abstract:
- lang: eng
  text: Games on graphs with ω-regular objectives provide a model for the control
    and synthesis of reactive systems. Every ω-regular objective can be decomposed
    into a safety part and a liveness part. The liveness part ensures that something
    good happens “eventually.” Two main strengths of the classical, infinite-limit
    formulation of liveness are robustness (independence from the granularity of transitions)
    and simplicity (abstraction of complicated time bounds). However, the classical
    liveness formulation suffers from the drawback that the time until something good
    happens may be unbounded. A stronger formulation of liveness, so-called finitary
    liveness, overcomes this drawback, while still retaining robustness and simplicity.
    Finitary liveness requires that there exists an unknown, fixed bound b such that
    something good happens within b transitions. While for one-shot liveness (reachability)
    objectives, classical and finitary liveness coincide, for repeated liveness (Büchi)
    objectives, the finitary formulation is strictly stronger. In this work we study
    games with finitary parity and Streett (fairness) objectives. We prove the determinacy
    of these games, present algorithms for solving these games, and characterize the
    memory requirements of winning strategies. Our algorithms can be used, for example,
    for synthesizing controllers that do not let the response time of a system increase
    without bound.
acknowledgement: This research was supported in part by the AFOSR MURI grant F49620-00-1-0327
  and the NSF ITR grant CCR-0225610.
alternative_title:
- LNCS
author:
- first_name: Krishnendu
  full_name: Krishnendu Chatterjee
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Thomas A
  full_name: Thomas Henzinger
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
citation:
  ama: 'Chatterjee K, Henzinger TA. Finitary winning in omega-regular games. In: Vol
    3920. Springer; 2006:257-271. doi:<a href="https://doi.org/10.1007/11691372_17">10.1007/11691372_17</a>'
  apa: 'Chatterjee, K., &#38; Henzinger, T. A. (2006). Finitary winning in omega-regular
    games (Vol. 3920, pp. 257–271). Presented at the TACAS: Tools and Algorithms for
    the Construction and Analysis of Systems, Springer. <a href="https://doi.org/10.1007/11691372_17">https://doi.org/10.1007/11691372_17</a>'
  chicago: Chatterjee, Krishnendu, and Thomas A Henzinger. “Finitary Winning in Omega-Regular
    Games,” 3920:257–71. Springer, 2006. <a href="https://doi.org/10.1007/11691372_17">https://doi.org/10.1007/11691372_17</a>.
  ieee: 'K. Chatterjee and T. A. Henzinger, “Finitary winning in omega-regular games,”
    presented at the TACAS: Tools and Algorithms for the Construction and Analysis
    of Systems, 2006, vol. 3920, pp. 257–271.'
  ista: 'Chatterjee K, Henzinger TA. 2006. Finitary winning in omega-regular games.
    TACAS: Tools and Algorithms for the Construction and Analysis of Systems, LNCS,
    vol. 3920, 257–271.'
  mla: Chatterjee, Krishnendu, and Thomas A. Henzinger. <i>Finitary Winning in Omega-Regular
    Games</i>. Vol. 3920, Springer, 2006, pp. 257–71, doi:<a href="https://doi.org/10.1007/11691372_17">10.1007/11691372_17</a>.
  short: K. Chatterjee, T.A. Henzinger, in:, Springer, 2006, pp. 257–271.
conference:
  name: 'TACAS: Tools and Algorithms for the Construction and Analysis of Systems'
date_created: 2018-12-11T12:09:22Z
date_published: 2006-03-15T00:00:00Z
date_updated: 2021-01-12T07:59:32Z
day: '15'
doi: 10.1007/11691372_17
extern: 1
intvolume: '      3920'
month: '03'
page: 257 - 271
publication_status: published
publisher: Springer
publist_id: '183'
quality_controlled: 0
status: public
title: Finitary winning in omega-regular games
type: conference
volume: 3920
year: '2006'
...
