---
_id: '847'
abstract:
- lang: eng
text: The accumulation of genome-wide information on single nucleotide polymorphisms
in humans provides an unprecedented opportunity to detect the evolutionary forces
responsible for heterogeneity of the level of genetic variability across loci.
Previous studies have shown that history of recombination events has produced
long haplotype blocks in the human genome, which contribute to this heterogeneity.
Other factors, however, such as natural selection or the heterogeneity of mutation
rates across loci, may also lead to heterogeneity of genetic variability. We compared
synonymous and non-synonymous variability within human genes with their divergence
from murine orthologs. We separately analyzed the non-synonymous variants predicted
to damage protein structure or function and the variants predicted to be functionally
benign. The predictions were based on comparative sequence analysis and, in some
cases, on the analysis of protein structure. A strong correlation between non-synonymous,
benign variability and non-synonymous human-mouse divergence suggests that selection
played an important role in shaping the pattern of variability in coding regions
of human genes. However, the lack of correlation between deleterious variability
and evolutionary divergence shows that a substantial proportion of the observed
non-synonymous single-nucleotide polymorphisms reduces fitness and never reaches
fixation. Evolutionary and medical implications of the impact of selection on
human polymorphisms are discussed.
acknowledgement: We are grateful to Alexey Kondrashov and Alison Wellman for the careful
reading of the manuscript and providing us with their valuable comments.
author:
- first_name: Shamil
full_name: Sunyaev, Shamil R
last_name: Sunyaev
- first_name: Fyodor
full_name: Fyodor Kondrashov
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
- first_name: Peer
full_name: Bork, Peer
last_name: Bork
- first_name: Vasily
full_name: Ramensky, Vasily
last_name: Ramensky
citation:
ama: Sunyaev S, Kondrashov F, Bork P, Ramensky V. Impact of selection, mutation
rate and genetic drift on human genetic variation. Human Molecular Genetics.
2003;12(24):3325-3330. doi:10.1093/hmg/ddg359
apa: Sunyaev, S., Kondrashov, F., Bork, P., & Ramensky, V. (2003). Impact of
selection, mutation rate and genetic drift on human genetic variation. Human
Molecular Genetics. Oxford University Press. https://doi.org/10.1093/hmg/ddg359
chicago: Sunyaev, Shamil, Fyodor Kondrashov, Peer Bork, and Vasily Ramensky. “Impact
of Selection, Mutation Rate and Genetic Drift on Human Genetic Variation.” Human
Molecular Genetics. Oxford University Press, 2003. https://doi.org/10.1093/hmg/ddg359.
ieee: S. Sunyaev, F. Kondrashov, P. Bork, and V. Ramensky, “Impact of selection,
mutation rate and genetic drift on human genetic variation,” Human Molecular
Genetics, vol. 12, no. 24. Oxford University Press, pp. 3325–3330, 2003.
ista: Sunyaev S, Kondrashov F, Bork P, Ramensky V. 2003. Impact of selection, mutation
rate and genetic drift on human genetic variation. Human Molecular Genetics. 12(24),
3325–3330.
mla: Sunyaev, Shamil, et al. “Impact of Selection, Mutation Rate and Genetic Drift
on Human Genetic Variation.” Human Molecular Genetics, vol. 12, no. 24,
Oxford University Press, 2003, pp. 3325–30, doi:10.1093/hmg/ddg359.
short: S. Sunyaev, F. Kondrashov, P. Bork, V. Ramensky, Human Molecular Genetics
12 (2003) 3325–3330.
date_created: 2018-12-11T11:48:49Z
date_published: 2003-12-15T00:00:00Z
date_updated: 2021-01-12T08:19:29Z
day: '15'
doi: 10.1093/hmg/ddg359
extern: 1
intvolume: ' 12'
issue: '24'
month: '12'
page: 3325 - 3330
publication: Human Molecular Genetics
publication_status: published
publisher: Oxford University Press
publist_id: '6803'
quality_controlled: 0
status: public
title: Impact of selection, mutation rate and genetic drift on human genetic variation
type: journal_article
volume: 12
year: '2003'
...
---
_id: '8519'
article_processing_charge: No
article_type: original
author:
- first_name: Vadim
full_name: Kaloshin, Vadim
id: FE553552-CDE8-11E9-B324-C0EBE5697425
last_name: Kaloshin
orcid: 0000-0002-6051-2628
citation:
ama: Kaloshin V. The existential Hilbert 16-th problem and an estimate for cyclicity
of elementary polycycles. Inventiones mathematicae. 2003;151(3):451-512.
doi:10.1007/s00222-002-0244-9
apa: Kaloshin, V. (2003). The existential Hilbert 16-th problem and an estimate
for cyclicity of elementary polycycles. Inventiones Mathematicae. Springer
Nature. https://doi.org/10.1007/s00222-002-0244-9
chicago: Kaloshin, Vadim. “The Existential Hilbert 16-Th Problem and an Estimate
for Cyclicity of Elementary Polycycles.” Inventiones Mathematicae. Springer
Nature, 2003. https://doi.org/10.1007/s00222-002-0244-9.
ieee: V. Kaloshin, “The existential Hilbert 16-th problem and an estimate for cyclicity
of elementary polycycles,” Inventiones mathematicae, vol. 151, no. 3. Springer
Nature, pp. 451–512, 2003.
ista: Kaloshin V. 2003. The existential Hilbert 16-th problem and an estimate for
cyclicity of elementary polycycles. Inventiones mathematicae. 151(3), 451–512.
mla: Kaloshin, Vadim. “The Existential Hilbert 16-Th Problem and an Estimate for
Cyclicity of Elementary Polycycles.” Inventiones Mathematicae, vol. 151,
no. 3, Springer Nature, 2003, pp. 451–512, doi:10.1007/s00222-002-0244-9.
short: V. Kaloshin, Inventiones Mathematicae 151 (2003) 451–512.
date_created: 2020-09-18T10:49:26Z
date_published: 2003-03-01T00:00:00Z
date_updated: 2021-01-12T08:19:50Z
day: '01'
doi: 10.1007/s00222-002-0244-9
extern: '1'
intvolume: ' 151'
issue: '3'
keyword:
- General Mathematics
language:
- iso: eng
month: '03'
oa_version: None
page: 451-512
publication: Inventiones mathematicae
publication_identifier:
issn:
- 0020-9910
- 1432-1297
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: The existential Hilbert 16-th problem and an estimate for cyclicity of elementary
polycycles
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 151
year: '2003'
...
---
_id: '876'
abstract:
- lang: eng
text: Alternative splicing is thought to be a major source of functional diversity
in animal proteins. We analyzed the evolutionary conservation of proteins encoded
by alternatively spliced genes and predicted the ancestral state for 73 cases
of alternative splicing (25 insertions and 48 deletions). The amino acid sequences
of most of the inserts in proteins produced by alternative splicing are as conserved
as the surrounding sequences. Thus, alternative splicing often creates novel isoforms
by the insertion of new, functional protein sequences that probably originated
from noncoding sequences of introns.
acknowledgement: We thank Peer Bork, Mikhail Gelfand, Alexey Kondrashov, David Lipman
and Shamil Sunyaev for critical reading of the manuscript and useful suggestions
and the Koonin group members for helpful discussions.
author:
- first_name: Fyodor
full_name: Fyodor Kondrashov
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
- first_name: Eugene
full_name: Koonin, Eugene V
last_name: Koonin
citation:
ama: 'Kondrashov F, Koonin E. Evolution of alternative splicing: Deletions, insertions
and origin of functional parts of proteins from intron sequences. Trends in
Genetics. 2003;19(3):115-119. doi:10.1016/S0168-9525(02)00029-X'
apa: 'Kondrashov, F., & Koonin, E. (2003). Evolution of alternative splicing:
Deletions, insertions and origin of functional parts of proteins from intron sequences.
Trends in Genetics. Elsevier. https://doi.org/10.1016/S0168-9525(02)00029-X'
chicago: 'Kondrashov, Fyodor, and Eugene Koonin. “Evolution of Alternative Splicing:
Deletions, Insertions and Origin of Functional Parts of Proteins from Intron Sequences.”
Trends in Genetics. Elsevier, 2003. https://doi.org/10.1016/S0168-9525(02)00029-X.'
ieee: 'F. Kondrashov and E. Koonin, “Evolution of alternative splicing: Deletions,
insertions and origin of functional parts of proteins from intron sequences,”
Trends in Genetics, vol. 19, no. 3. Elsevier, pp. 115–119, 2003.'
ista: 'Kondrashov F, Koonin E. 2003. Evolution of alternative splicing: Deletions,
insertions and origin of functional parts of proteins from intron sequences. Trends
in Genetics. 19(3), 115–119.'
mla: 'Kondrashov, Fyodor, and Eugene Koonin. “Evolution of Alternative Splicing:
Deletions, Insertions and Origin of Functional Parts of Proteins from Intron Sequences.”
Trends in Genetics, vol. 19, no. 3, Elsevier, 2003, pp. 115–19, doi:10.1016/S0168-9525(02)00029-X.'
short: F. Kondrashov, E. Koonin, Trends in Genetics 19 (2003) 115–119.
date_created: 2018-12-11T11:48:58Z
date_published: 2003-01-01T00:00:00Z
date_updated: 2021-01-12T08:20:58Z
day: '01'
doi: 10.1016/S0168-9525(02)00029-X
extern: 1
intvolume: ' 19'
issue: '3'
month: '01'
page: 115 - 119
publication: Trends in Genetics
publication_status: published
publisher: Elsevier
publist_id: '6776'
quality_controlled: 0
status: public
title: 'Evolution of alternative splicing: Deletions, insertions and origin of functional
parts of proteins from intron sequences'
type: journal_article
volume: 19
year: '2003'
...
---
_id: '166'
abstract:
- lang: eng
text: For any number field k, upper bounds are established for the number of k-rational
points of bounded height on non-singular del Pezzo surfaces defined over k, which
are equipped with suitable conic bundle structures over k.
alternative_title:
- Bonner mathematische Schriften
arxiv: 1
author:
- first_name: Timothy D
full_name: Browning, Timothy D
id: 35827D50-F248-11E8-B48F-1D18A9856A87
last_name: Browning
orcid: 0000-0002-8314-0177
- first_name: M
full_name: Swarbick Jones, M
last_name: Swarbick Jones
citation:
ama: Browning TD, Swarbick Jones M. Counting rational points on del Pezzo surfaces
of degree 5. Proceedings of the Bonn session in analytic number theory and
diophantine equations. 2003;360.
apa: Browning, T. D., & Swarbick Jones, M. (2003). Counting rational points
on del Pezzo surfaces of degree 5. Proceedings of the Bonn Session in Analytic
Number Theory and Diophantine Equations. Mathematisches Institut der Universität
Bonn.
chicago: Browning, Timothy D, and M Swarbick Jones. “Counting Rational Points on
Del Pezzo Surfaces of Degree 5.” Proceedings of the Bonn Session in Analytic
Number Theory and Diophantine Equations. Mathematisches Institut der Universität
Bonn, 2003.
ieee: T. D. Browning and M. Swarbick Jones, “Counting rational points on del Pezzo
surfaces of degree 5,” Proceedings of the Bonn session in analytic number theory
and diophantine equations, vol. 360. Mathematisches Institut der Universität
Bonn, 2003.
ista: Browning TD, Swarbick Jones M. 2003. Counting rational points on del Pezzo
surfaces of degree 5. Proceedings of the Bonn session in analytic number theory
and diophantine equations. 360.
mla: Browning, Timothy D., and M. Swarbick Jones. “Counting Rational Points on Del
Pezzo Surfaces of Degree 5.” Proceedings of the Bonn Session in Analytic Number
Theory and Diophantine Equations, vol. 360, Mathematisches Institut der Universität
Bonn, 2003.
short: T.D. Browning, M. Swarbick Jones, Proceedings of the Bonn Session in Analytic
Number Theory and Diophantine Equations 360 (2003).
date_created: 2018-12-11T11:44:58Z
date_published: 2003-01-01T00:00:00Z
date_updated: 2021-01-12T06:52:20Z
day: '01'
extern: '1'
external_id:
arxiv:
- '1311.1665'
intvolume: ' 360'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1311.1665
month: '01'
oa: 1
oa_version: None
publication: Proceedings of the Bonn session in analytic number theory and diophantine
equations
publication_status: published
publisher: Mathematisches Institut der Universität Bonn
publist_id: '7755'
status: public
title: Counting rational points on del Pezzo surfaces of degree 5
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 360
year: '2003'
...
---
_id: '1959'
abstract:
- lang: eng
text: 'The molecular organization of bacterial NADH: ubiquinone oxidoreductase (complex
I or NDH-1) is not established, apart from a rough separation into dehydrogenase,
connecting and membrane domains. In this work, complex I was purified from Escherichia
coli and fragmented by replacing dodecylmaltoside with other detergents. Exchange
into decyl maltoside led to the removal of the hydrophobic subunit NuoL from the
otherwise intact complex. Diheptanoyl phosphocholine led to the loss of NuoL and
NuoM subunits, whereas other subunits remained in the complex. The presence of
N,N-dimethyldodecylamine N-oxide or Triton X-100 led to further disruption of
the membrane domain into fragments containing NuoL/M/N, NuoA/K/N, and NuoH/J subunits.
Among the hydrophilic subunits, NuoCD was most readily dissociated from the complex,
whereas NuoB was partially dissociated from the peripheral arm assembly in N,N-dimethyldodecylamine
N-oxide. A model of subunit arrangement in bacterial complex I based on these
data is proposed. Subunits NuoL and NuoM, which are homologous to antiporters
and are implicated in proton pumping, are located at the distal end of the membrane
arm, spatially separated from the redox centers of the peripheral arm. This is
consistent with proposals that the mechanism of proton pumping by complex I is
likely to involve long range conformational changes.'
acknowledgement: his work was supported by the Medical Research Council.
author:
- first_name: Peter
full_name: Holt, Peter J
last_name: Holt
- first_name: David
full_name: Morgan, David J
last_name: Morgan
- first_name: Leonid A
full_name: Leonid Sazanov
id: 338D39FE-F248-11E8-B48F-1D18A9856A87
last_name: Sazanov
orcid: 0000-0002-0977-7989
citation:
ama: 'Holt P, Morgan D, Sazanov LA. The location of NuoL and NuoM subunits in the
membrane domain of the Escherichia coli Complex I: implications for the mechanism
of proton pumping. Journal of Biological Chemistry. 2003;278(44):43114-43120.
doi:10.1074/jbc.M308247200'
apa: 'Holt, P., Morgan, D., & Sazanov, L. A. (2003). The location of NuoL and
NuoM subunits in the membrane domain of the Escherichia coli Complex I: implications
for the mechanism of proton pumping. Journal of Biological Chemistry. American
Society for Biochemistry and Molecular Biology. https://doi.org/10.1074/jbc.M308247200'
chicago: 'Holt, Peter, David Morgan, and Leonid A Sazanov. “The Location of NuoL
and NuoM Subunits in the Membrane Domain of the Escherichia Coli Complex I: Implications
for the Mechanism of Proton Pumping.” Journal of Biological Chemistry.
American Society for Biochemistry and Molecular Biology, 2003. https://doi.org/10.1074/jbc.M308247200.'
ieee: 'P. Holt, D. Morgan, and L. A. Sazanov, “The location of NuoL and NuoM subunits
in the membrane domain of the Escherichia coli Complex I: implications for the
mechanism of proton pumping,” Journal of Biological Chemistry, vol. 278,
no. 44. American Society for Biochemistry and Molecular Biology, pp. 43114–43120,
2003.'
ista: 'Holt P, Morgan D, Sazanov LA. 2003. The location of NuoL and NuoM subunits
in the membrane domain of the Escherichia coli Complex I: implications for the
mechanism of proton pumping. Journal of Biological Chemistry. 278(44), 43114–43120.'
mla: 'Holt, Peter, et al. “The Location of NuoL and NuoM Subunits in the Membrane
Domain of the Escherichia Coli Complex I: Implications for the Mechanism of Proton
Pumping.” Journal of Biological Chemistry, vol. 278, no. 44, American Society
for Biochemistry and Molecular Biology, 2003, pp. 43114–20, doi:10.1074/jbc.M308247200.'
short: P. Holt, D. Morgan, L.A. Sazanov, Journal of Biological Chemistry 278 (2003)
43114–43120.
date_created: 2018-12-11T11:54:55Z
date_published: 2003-10-31T00:00:00Z
date_updated: 2021-01-12T06:54:21Z
day: '31'
doi: 10.1074/jbc.M308247200
extern: 1
intvolume: ' 278'
issue: '44'
month: '10'
page: 43114 - 43120
publication: Journal of Biological Chemistry
publication_status: published
publisher: American Society for Biochemistry and Molecular Biology
publist_id: '5124'
quality_controlled: 0
status: public
title: 'The location of NuoL and NuoM subunits in the membrane domain of the Escherichia
coli Complex I: implications for the mechanism of proton pumping'
type: journal_article
volume: 278
year: '2003'
...
---
_id: '1960'
abstract:
- lang: eng
text: NADH-ubiquinone oxidoreductase (complex I or NDH-1) was purified from the
BL21 strain of Escherichia coli using an improved procedure. The complex was effectively
stabilized by addition of divalent cations and lipids, making the preparation
suitable for structural studies. The ubiquinone reductase activity of the enzyme
was fully restored by addition of native E. coli lipids. Two different two-dimensional
crystal forms, with p2 and p3 symmetry, were obtained using lipids containing
native E. coli extracts. Analysis of the crystals showed that they are formed
by fully intact complex I in an L-shaped conformation. Activity assays and single
particle analysis indicated that complex I maintains this structure in detergent
solution and does not adopt a different conformation in the active state. Thus,
we provide the first experimental evidence that complex I from E. coli has an
L-shape in a lipid bilayer and confirm that this is also the case for the active
enzyme in solution. This suggests strongly that bacterial complex I exists in
an L-shaped conformation in vivo. Our results also indicate that native lipids
play an important role in the activation, stabilization and, as a consequence,
crystallization of purified complex I from E. coli.
author:
- first_name: Leonid A
full_name: Leonid Sazanov
id: 338D39FE-F248-11E8-B48F-1D18A9856A87
last_name: Sazanov
orcid: 0000-0002-0977-7989
- first_name: Joe
full_name: Carroll, Joe D
last_name: Carroll
- first_name: Peter
full_name: Holt, Peter J
last_name: Holt
- first_name: Laurence
full_name: Toime, Laurence J
last_name: Toime
- first_name: Ian
full_name: Fearnley, Ian M
last_name: Fearnley
citation:
ama: Sazanov LA, Carroll J, Holt P, Toime L, Fearnley I. A role for native lipids
in the stabilization and two dimensional crystallization of the Escherichia coli
NADH ubiquinone oxidoreductase (complex I). Journal of Biological Chemistry.
2003;278(21):19483-19491. doi:10.1074/jbc.M208959200
apa: Sazanov, L. A., Carroll, J., Holt, P., Toime, L., & Fearnley, I. (2003).
A role for native lipids in the stabilization and two dimensional crystallization
of the Escherichia coli NADH ubiquinone oxidoreductase (complex I). Journal
of Biological Chemistry. American Society for Biochemistry and Molecular Biology.
https://doi.org/10.1074/jbc.M208959200
chicago: Sazanov, Leonid A, Joe Carroll, Peter Holt, Laurence Toime, and Ian Fearnley.
“A Role for Native Lipids in the Stabilization and Two Dimensional Crystallization
of the Escherichia Coli NADH Ubiquinone Oxidoreductase (Complex I).” Journal
of Biological Chemistry. American Society for Biochemistry and Molecular Biology,
2003. https://doi.org/10.1074/jbc.M208959200.
ieee: L. A. Sazanov, J. Carroll, P. Holt, L. Toime, and I. Fearnley, “A role for
native lipids in the stabilization and two dimensional crystallization of the
Escherichia coli NADH ubiquinone oxidoreductase (complex I),” Journal of Biological
Chemistry, vol. 278, no. 21. American Society for Biochemistry and Molecular
Biology, pp. 19483–19491, 2003.
ista: Sazanov LA, Carroll J, Holt P, Toime L, Fearnley I. 2003. A role for native
lipids in the stabilization and two dimensional crystallization of the Escherichia
coli NADH ubiquinone oxidoreductase (complex I). Journal of Biological Chemistry.
278(21), 19483–19491.
mla: Sazanov, Leonid A., et al. “A Role for Native Lipids in the Stabilization and
Two Dimensional Crystallization of the Escherichia Coli NADH Ubiquinone Oxidoreductase
(Complex I).” Journal of Biological Chemistry, vol. 278, no. 21, American
Society for Biochemistry and Molecular Biology, 2003, pp. 19483–91, doi:10.1074/jbc.M208959200.
short: L.A. Sazanov, J. Carroll, P. Holt, L. Toime, I. Fearnley, Journal of Biological
Chemistry 278 (2003) 19483–19491.
date_created: 2018-12-11T11:54:55Z
date_published: 2003-05-23T00:00:00Z
date_updated: 2021-01-12T06:54:21Z
day: '23'
doi: 10.1074/jbc.M208959200
extern: 1
intvolume: ' 278'
issue: '21'
month: '05'
page: 19483 - 19491
publication: Journal of Biological Chemistry
publication_status: published
publisher: American Society for Biochemistry and Molecular Biology
publist_id: '5125'
quality_controlled: 0
status: public
title: A role for native lipids in the stabilization and two dimensional crystallization
of the Escherichia coli NADH ubiquinone oxidoreductase (complex I)
type: journal_article
volume: 278
year: '2003'
...
---
_id: '205'
author:
- first_name: Timothy D
full_name: Timothy Browning
id: 35827D50-F248-11E8-B48F-1D18A9856A87
last_name: Browning
orcid: 0000-0002-8314-0177
citation:
ama: Browning TD. Counting rational points on cubic and quartic surfaces. Acta
Arithmetica. 2003;108(3):275-295. doi:10.4064/aa108-3-7
apa: Browning, T. D. (2003). Counting rational points on cubic and quartic surfaces.
Acta Arithmetica. Instytut Matematyczny. https://doi.org/10.4064/aa108-3-7
chicago: Browning, Timothy D. “Counting Rational Points on Cubic and Quartic Surfaces.”
Acta Arithmetica. Instytut Matematyczny, 2003. https://doi.org/10.4064/aa108-3-7.
ieee: T. D. Browning, “Counting rational points on cubic and quartic surfaces,”
Acta Arithmetica, vol. 108, no. 3. Instytut Matematyczny, pp. 275–295,
2003.
ista: Browning TD. 2003. Counting rational points on cubic and quartic surfaces.
Acta Arithmetica. 108(3), 275–295.
mla: Browning, Timothy D. “Counting Rational Points on Cubic and Quartic Surfaces.”
Acta Arithmetica, vol. 108, no. 3, Instytut Matematyczny, 2003, pp. 275–95,
doi:10.4064/aa108-3-7.
short: T.D. Browning, Acta Arithmetica 108 (2003) 275–295.
date_created: 2018-12-11T11:45:12Z
date_published: 2003-01-01T00:00:00Z
date_updated: 2021-01-12T06:54:58Z
day: '01'
doi: 10.4064/aa108-3-7
extern: 1
intvolume: ' 108'
issue: '3'
month: '01'
page: 275 - 295
publication: Acta Arithmetica
publication_status: published
publisher: Instytut Matematyczny
publist_id: '7707'
quality_controlled: 0
status: public
title: Counting rational points on cubic and quartic surfaces
type: journal_article
volume: 108
year: '2003'
...
---
_id: '206'
abstract:
- lang: eng
text: Let T ⊂ ℙ 4 be a non-singular threefold of degree at least four. Then we show
that the number of points in T(ℚ), with height at most B, is o(B 3) or B → ∞.
author:
- first_name: Timothy D
full_name: Timothy Browning
id: 35827D50-F248-11E8-B48F-1D18A9856A87
last_name: Browning
orcid: 0000-0002-8314-0177
citation:
ama: Browning TD. A note on the distribution of rational points on threefolds. Quarterly
Journal of Mathematics. 2003;54(1):33-39. doi:10.1093/qjmath/54.1.33
apa: Browning, T. D. (2003). A note on the distribution of rational points on threefolds.
Quarterly Journal of Mathematics. Unknown. https://doi.org/10.1093/qjmath/54.1.33
chicago: Browning, Timothy D. “A Note on the Distribution of Rational Points on
Threefolds.” Quarterly Journal of Mathematics. Unknown, 2003. https://doi.org/10.1093/qjmath/54.1.33.
ieee: T. D. Browning, “A note on the distribution of rational points on threefolds,”
Quarterly Journal of Mathematics, vol. 54, no. 1. Unknown, pp. 33–39, 2003.
ista: Browning TD. 2003. A note on the distribution of rational points on threefolds.
Quarterly Journal of Mathematics. 54(1), 33–39.
mla: Browning, Timothy D. “A Note on the Distribution of Rational Points on Threefolds.”
Quarterly Journal of Mathematics, vol. 54, no. 1, Unknown, 2003, pp. 33–39,
doi:10.1093/qjmath/54.1.33.
short: T.D. Browning, Quarterly Journal of Mathematics 54 (2003) 33–39.
date_created: 2018-12-11T11:45:12Z
date_published: 2003-03-01T00:00:00Z
date_updated: 2021-01-12T06:55:02Z
day: '01'
doi: 10.1093/qjmath/54.1.33
extern: 1
intvolume: ' 54'
issue: '1'
month: '03'
page: 33 - 39
publication: Quarterly Journal of Mathematics
publication_status: published
publisher: Unknown
publist_id: '7706'
quality_controlled: 0
status: public
title: A note on the distribution of rational points on threefolds
type: journal_article
volume: 54
year: '2003'
...
---
_id: '13436'
abstract:
- lang: eng
text: Cross-metathesis reactions of α,β-unsaturated sulfones and sulfoxides in the
presence of molybdenum and ruthenium pre-catalysts were tested. A selective metahesis
reaction was achieved between functionalized terminal olefins and vinyl sulfones
by using the ‘second generation’ ruthenium catalysts 1c–h while the highly active
Schrock catalyst 1b was found to be functional group incompatible with vinyl sulfones.
The cross-metathesis products were isolated in good yields with an excellent (E)-selectivity.
Both the molybdenum and ruthenium-based complexes were, however, incompatible
with α,β- and β,γ-unsaturated sulfoxides.
article_processing_charge: No
article_type: original
author:
- first_name: Anna
full_name: Michrowska, Anna
last_name: Michrowska
- first_name: Michał
full_name: Bieniek, Michał
last_name: Bieniek
- first_name: Mikhail
full_name: Kim, Mikhail
last_name: Kim
- first_name: Rafal
full_name: Klajn, Rafal
id: 8e84690e-1e48-11ed-a02b-a1e6fb8bb53b
last_name: Klajn
- first_name: Karol
full_name: Grela, Karol
last_name: Grela
citation:
ama: Michrowska A, Bieniek M, Kim M, Klajn R, Grela K. Cross-metathesis reaction
of vinyl sulfones and sulfoxides. Tetrahedron. 2003;59(25):4525-4531. doi:10.1016/s0040-4020(03)00682-3
apa: Michrowska, A., Bieniek, M., Kim, M., Klajn, R., & Grela, K. (2003). Cross-metathesis
reaction of vinyl sulfones and sulfoxides. Tetrahedron. Elsevier. https://doi.org/10.1016/s0040-4020(03)00682-3
chicago: Michrowska, Anna, Michał Bieniek, Mikhail Kim, Rafal Klajn, and Karol Grela.
“Cross-Metathesis Reaction of Vinyl Sulfones and Sulfoxides.” Tetrahedron.
Elsevier, 2003. https://doi.org/10.1016/s0040-4020(03)00682-3.
ieee: A. Michrowska, M. Bieniek, M. Kim, R. Klajn, and K. Grela, “Cross-metathesis
reaction of vinyl sulfones and sulfoxides,” Tetrahedron, vol. 59, no. 25.
Elsevier, pp. 4525–4531, 2003.
ista: Michrowska A, Bieniek M, Kim M, Klajn R, Grela K. 2003. Cross-metathesis reaction
of vinyl sulfones and sulfoxides. Tetrahedron. 59(25), 4525–4531.
mla: Michrowska, Anna, et al. “Cross-Metathesis Reaction of Vinyl Sulfones and Sulfoxides.”
Tetrahedron, vol. 59, no. 25, Elsevier, 2003, pp. 4525–31, doi:10.1016/s0040-4020(03)00682-3.
short: A. Michrowska, M. Bieniek, M. Kim, R. Klajn, K. Grela, Tetrahedron 59 (2003)
4525–4531.
date_created: 2023-08-01T10:39:34Z
date_published: 2003-06-16T00:00:00Z
date_updated: 2023-08-08T12:44:17Z
day: '16'
doi: 10.1016/s0040-4020(03)00682-3
extern: '1'
intvolume: ' 59'
issue: '25'
keyword:
- Organic Chemistry
- Drug Discovery
- Biochemistry
language:
- iso: eng
month: '06'
oa_version: None
page: 4525-4531
publication: Tetrahedron
publication_identifier:
eissn:
- 1464-5416
issn:
- 0040-4020
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Cross-metathesis reaction of vinyl sulfones and sulfoxides
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 59
year: '2003'
...
---
_id: '1457'
abstract:
- lang: eng
text: 'Among the major mathematical approaches to mirror symmetry are those of Batyrev-Borisov
and Stromdnger-Yau-Zaslow (SYZ). The first is explicit and amenable to computation
but is not clearly related to the physical motivation; the second is the opposite.
Furthermore, it is far from obvious that mirror partners in one sense will also
be mirror partners in the other. This paper concerns a class of examples that
can be shown to satisfy the requirements of SYZ, but whose Hodge numbers are also
equal. This provides significant evidence in support of SYZ. Moreover, the examples
are of great interest in their own right: they are spaces of flat SLr-connections
on a smooth curve. The mirror is the corresponding space for the Langlands dual
group PGLr. These examples therefore throw a bridge from mirror symmetry to the
duality theory of Lie groups and, more broadly, to the geometric Langlands program.'
author:
- first_name: Tamas
full_name: Tamas Hausel
id: 4A0666D8-F248-11E8-B48F-1D18A9856A87
last_name: Hausel
- first_name: Michael
full_name: Thaddeus, Michael
last_name: Thaddeus
citation:
ama: Hausel T, Thaddeus M. Mirror symmetry, langlands duality, and the Hitchin system.
Inventiones Mathematicae. 2003;153(1):197-229. doi:10.1007/s00222-003-0286-7
apa: Hausel, T., & Thaddeus, M. (2003). Mirror symmetry, langlands duality,
and the Hitchin system. Inventiones Mathematicae. Springer. https://doi.org/10.1007/s00222-003-0286-7
chicago: Hausel, Tamás, and Michael Thaddeus. “Mirror Symmetry, Langlands Duality,
and the Hitchin System.” Inventiones Mathematicae. Springer, 2003. https://doi.org/10.1007/s00222-003-0286-7.
ieee: T. Hausel and M. Thaddeus, “Mirror symmetry, langlands duality, and the Hitchin
system,” Inventiones Mathematicae, vol. 153, no. 1. Springer, pp. 197–229,
2003.
ista: Hausel T, Thaddeus M. 2003. Mirror symmetry, langlands duality, and the Hitchin
system. Inventiones Mathematicae. 153(1), 197–229.
mla: Hausel, Tamás, and Michael Thaddeus. “Mirror Symmetry, Langlands Duality, and
the Hitchin System.” Inventiones Mathematicae, vol. 153, no. 1, Springer,
2003, pp. 197–229, doi:10.1007/s00222-003-0286-7.
short: T. Hausel, M. Thaddeus, Inventiones Mathematicae 153 (2003) 197–229.
date_created: 2018-12-11T11:52:08Z
date_published: 2003-07-01T00:00:00Z
date_updated: 2021-01-12T06:50:52Z
day: '01'
doi: 10.1007/s00222-003-0286-7
extern: 1
intvolume: ' 153'
issue: '1'
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/math/0205236
month: '07'
oa: 1
page: 197 - 229
publication: Inventiones Mathematicae
publication_status: published
publisher: Springer
publist_id: '5738'
quality_controlled: 0
status: public
title: Mirror symmetry, langlands duality, and the Hitchin system
type: journal_article
volume: 153
year: '2003'
...
---
_id: '1458'
abstract:
- lang: eng
text: The moduli space of stable bundles of rank $2$ and degree $1$ on a Riemann
surface has rational cohomology generated by the so-called universal classes.
The work of Baranovsky, King-Newstead, Siebert-Tian and Zagier provided a complete
set of relations between these classes, expressed in terms of a recursion in the
genus. This paper accomplishes the same thing for the noncompact moduli spaces
of Higgs bundles, in the sense of Hitchin and Simpson. There are many more independent
relations than for stable bundles, but in a sense the answer is simpler, since
the formulas are completely explicit, not recursive. The results of Kirwan on
equivariant cohomology for holomorphic circle actions are of key importance.
acknowledgement: The first author was supported by NSF grant DMS-97-29992. The second
author was supported by NSF grant DMS-98-08529.
author:
- first_name: Tamas
full_name: Tamas Hausel
id: 4A0666D8-F248-11E8-B48F-1D18A9856A87
last_name: Hausel
- first_name: Michael
full_name: Thaddeus, Michael
last_name: Thaddeus
citation:
ama: Hausel T, Thaddeus M. Relations in the cohomology ring of the moduli space
of rank 2 Higgs bundles. Journal of the American Mathematical Society.
2003;16(2):303-329. doi:10.1090/S0894-0347-02-00417-4
apa: Hausel, T., & Thaddeus, M. (2003). Relations in the cohomology ring of
the moduli space of rank 2 Higgs bundles. Journal of the American Mathematical
Society. American Mathematical Society. https://doi.org/10.1090/S0894-0347-02-00417-4
chicago: Hausel, Tamás, and Michael Thaddeus. “Relations in the Cohomology Ring
of the Moduli Space of Rank 2 Higgs Bundles.” Journal of the American Mathematical
Society. American Mathematical Society, 2003. https://doi.org/10.1090/S0894-0347-02-00417-4.
ieee: T. Hausel and M. Thaddeus, “Relations in the cohomology ring of the moduli
space of rank 2 Higgs bundles,” Journal of the American Mathematical Society,
vol. 16, no. 2. American Mathematical Society, pp. 303–329, 2003.
ista: Hausel T, Thaddeus M. 2003. Relations in the cohomology ring of the moduli
space of rank 2 Higgs bundles. Journal of the American Mathematical Society. 16(2),
303–329.
mla: Hausel, Tamás, and Michael Thaddeus. “Relations in the Cohomology Ring of the
Moduli Space of Rank 2 Higgs Bundles.” Journal of the American Mathematical
Society, vol. 16, no. 2, American Mathematical Society, 2003, pp. 303–29,
doi:10.1090/S0894-0347-02-00417-4.
short: T. Hausel, M. Thaddeus, Journal of the American Mathematical Society 16 (2003)
303–329.
date_created: 2018-12-11T11:52:08Z
date_published: 2003-04-01T00:00:00Z
date_updated: 2021-01-12T06:50:53Z
day: '01'
doi: 10.1090/S0894-0347-02-00417-4
extern: 1
intvolume: ' 16'
issue: '2'
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/math/0003094
month: '04'
oa: 1
page: 303 - 329
publication: Journal of the American Mathematical Society
publication_status: published
publisher: American Mathematical Society
publist_id: '5739'
quality_controlled: 0
status: public
title: Relations in the cohomology ring of the moduli space of rank 2 Higgs bundles
type: journal_article
volume: 16
year: '2003'
...
---
_id: '1459'
abstract:
- lang: eng
text: 'In this paper we explicitly calculate the analogue of the ''t Hooft SU (2)
Yang-Mills instantons on Gibbons-Hawking multi-centered gravitational instantons,
which come in two parallel families: the multi-Eguchi-Hanson, or Ak ALE gravitational
instantons and the multi-Taub-NUT spaces, or Ak ALF gravitational instantons.
We calculate their energy and find the reducible ones. Following Kronheimer we
also exploit the U(1) invariance of our solutions and study the corresponding
explicit singular SU (2) magnetic monopole solutions of the Bogomolny equations
on flat ℝ3.'
acknowledgement: We would like to acknowledge the financial support by Prof. P. Major
(R ́ enyi Institute, Hungary) from his OTKA grant No. T26176 and of the Miller Institute
for Basic Research in Science at UC Berkeley.
author:
- first_name: Gábor
full_name: Etesi, Gábor
last_name: Etesi
- first_name: Tamas
full_name: Tamas Hausel
id: 4A0666D8-F248-11E8-B48F-1D18A9856A87
last_name: Hausel
citation:
ama: Etesi G, Hausel T. On Yang-Mills instantons over multi-centered gravitational
instantons. Communications in Mathematical Physics. 2003;235(2):275-288.
doi:10.1007/s00220-003-0806-8
apa: Etesi, G., & Hausel, T. (2003). On Yang-Mills instantons over multi-centered
gravitational instantons. Communications in Mathematical Physics. Springer.
https://doi.org/10.1007/s00220-003-0806-8
chicago: Etesi, Gábor, and Tamás Hausel. “On Yang-Mills Instantons over Multi-Centered
Gravitational Instantons.” Communications in Mathematical Physics. Springer,
2003. https://doi.org/10.1007/s00220-003-0806-8.
ieee: G. Etesi and T. Hausel, “On Yang-Mills instantons over multi-centered gravitational
instantons,” Communications in Mathematical Physics, vol. 235, no. 2. Springer,
pp. 275–288, 2003.
ista: Etesi G, Hausel T. 2003. On Yang-Mills instantons over multi-centered gravitational
instantons. Communications in Mathematical Physics. 235(2), 275–288.
mla: Etesi, Gábor, and Tamás Hausel. “On Yang-Mills Instantons over Multi-Centered
Gravitational Instantons.” Communications in Mathematical Physics, vol.
235, no. 2, Springer, 2003, pp. 275–88, doi:10.1007/s00220-003-0806-8.
short: G. Etesi, T. Hausel, Communications in Mathematical Physics 235 (2003) 275–288.
date_created: 2018-12-11T11:52:09Z
date_published: 2003-04-01T00:00:00Z
date_updated: 2021-01-12T06:50:53Z
day: '01'
doi: 10.1007/s00220-003-0806-8
extern: 1
intvolume: ' 235'
issue: '2'
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/hep-th/0207196
month: '04'
oa: 1
page: 275 - 288
publication: Communications in Mathematical Physics
publication_status: published
publisher: Springer
publist_id: '5740'
quality_controlled: 0
status: public
title: On Yang-Mills instantons over multi-centered gravitational instantons
type: journal_article
volume: 235
year: '2003'
...
---
_id: '576'
abstract:
- lang: eng
text: 'We study the free expansion of a pancake-shaped Bose-condensed gas, which
is initially trapped under harmonic confinement and containing a vortex at its
centre. In the case of a radial expansion holding the axial confinement fixed
we consider various models for the interactions, depending on the thickness of
the condensate relative to the value of the scattering length. We are thus able
to evaluate different scattering regimes ranging from quasi-three-dimensional
(Q3D) to strictly two-dimensional (2D). We find that as the system goes from Q3D
to 2D the expansion rate of the condensate increases whereas that of the vortex
core decreases. In the Q3D scattering regime we also examine a fully free expansion
in 3D and find oscillatory behaviour for the vortex core radius: an initial fast
expansion of the vortex core is followed by a slowing down. Such a nonuniform
expansion rate of the vortex core implies that the timing of its observation should
be chosen appropriately.'
author:
- first_name: Onur
full_name: Onur Hosten
id: 4C02D85E-F248-11E8-B48F-1D18A9856A87
last_name: Hosten
orcid: 0000-0002-2031-204X
- first_name: Patrizia
full_name: Vignolo, Patrizia
last_name: Vignolo
- first_name: Anna
full_name: Minguzzi, Anna
last_name: Minguzzi
- first_name: Bilal
full_name: Tanatar, Bilal
last_name: Tanatar
- first_name: Mario
full_name: Tosi, Mario P
last_name: Tosi
citation:
ama: 'Hosten O, Vignolo P, Minguzzi A, Tanatar B, Tosi M. Free expansion of two-dimensional
condensates with a vortex. Journal of Physics B: Atomic, Molecular and Optical
Physics. 2003;36(12):2455-2463. doi:10.1088/0953-4075/36/12/306'
apa: 'Hosten, O., Vignolo, P., Minguzzi, A., Tanatar, B., & Tosi, M. (2003).
Free expansion of two-dimensional condensates with a vortex. Journal of Physics
B: Atomic, Molecular and Optical Physics. IOP Publishing Ltd. https://doi.org/10.1088/0953-4075/36/12/306'
chicago: 'Hosten, Onur, Patrizia Vignolo, Anna Minguzzi, Bilal Tanatar, and Mario
Tosi. “Free Expansion of Two-Dimensional Condensates with a Vortex.” Journal
of Physics B: Atomic, Molecular and Optical Physics. IOP Publishing Ltd.,
2003. https://doi.org/10.1088/0953-4075/36/12/306.'
ieee: 'O. Hosten, P. Vignolo, A. Minguzzi, B. Tanatar, and M. Tosi, “Free expansion
of two-dimensional condensates with a vortex,” Journal of Physics B: Atomic,
Molecular and Optical Physics, vol. 36, no. 12. IOP Publishing Ltd., pp. 2455–2463,
2003.'
ista: 'Hosten O, Vignolo P, Minguzzi A, Tanatar B, Tosi M. 2003. Free expansion
of two-dimensional condensates with a vortex. Journal of Physics B: Atomic, Molecular
and Optical Physics. 36(12), 2455–2463.'
mla: 'Hosten, Onur, et al. “Free Expansion of Two-Dimensional Condensates with a
Vortex.” Journal of Physics B: Atomic, Molecular and Optical Physics, vol.
36, no. 12, IOP Publishing Ltd., 2003, pp. 2455–63, doi:10.1088/0953-4075/36/12/306.'
short: 'O. Hosten, P. Vignolo, A. Minguzzi, B. Tanatar, M. Tosi, Journal of Physics
B: Atomic, Molecular and Optical Physics 36 (2003) 2455–2463.'
date_created: 2018-12-11T11:47:16Z
date_published: 2003-06-28T00:00:00Z
date_updated: 2021-01-12T08:03:20Z
day: '28'
doi: 10.1088/0953-4075/36/12/306
extern: 1
intvolume: ' 36'
issue: '12'
month: '06'
page: 2455 - 2463
publication: 'Journal of Physics B: Atomic, Molecular and Optical Physics'
publication_status: published
publisher: IOP Publishing Ltd.
publist_id: '7239'
quality_controlled: 0
status: public
title: Free expansion of two-dimensional condensates with a vortex
type: journal_article
volume: 36
year: '2003'
...
---
_id: '6156'
abstract:
- lang: eng
text: 'Social and solitary feeding in natural Caenorhabditis elegans isolates are
associated with two alleles of the orphan G-protein-coupled receptor (GPCR) NPR-1:
social feeders contain NPR-1 215F, whereas solitary feeders contain NPR-1 215V.
Here we identify FMRFamide-related neuropeptides (FaRPs) encoded by the flp-18
and flp-21 genes as NPR-1 ligands and show that these peptides can differentially
activate the NPR-1 215F and NPR-1 215V receptors. Multicopy overexpression of
flp-21 transformed wild social animals into solitary feeders. Conversely, a flp-21
deletion partially phenocopied the npr-1(null) phenotype, which is consistent
with NPR-1 activation by FLP-21 in vivo but also implicates other ligands for
NPR-1. Phylogenetic studies indicate that the dominant npr-1 215V allele likely
arose from an ancestral npr-1 215F gene in C. elegans. Our data suggest a model
in which solitary feeding evolved in an ancestral social strain of C. elegans
by a gain-of-function mutation that modified the response of NPR-1 to FLP-18 and
FLP-21 ligands.'
author:
- first_name: Candida
full_name: Rogers, Candida
last_name: Rogers
- first_name: Vincenzina
full_name: Reale, Vincenzina
last_name: Reale
- first_name: Kyuhyung
full_name: Kim, Kyuhyung
last_name: Kim
- first_name: Heather
full_name: Chatwin, Heather
last_name: Chatwin
- first_name: Chris
full_name: Li, Chris
last_name: Li
- first_name: Peter
full_name: Evans, Peter
last_name: Evans
- first_name: Mario
full_name: de Bono, Mario
id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
last_name: de Bono
orcid: 0000-0001-8347-0443
citation:
ama: Rogers C, Reale V, Kim K, et al. Inhibition of Caenorhabditis elegans social
feeding by FMRFamide-related peptide activation of NPR-1. Nature Neuroscience.
2003;6(11):1178-1185. doi:10.1038/nn1140
apa: Rogers, C., Reale, V., Kim, K., Chatwin, H., Li, C., Evans, P., & de Bono,
M. (2003). Inhibition of Caenorhabditis elegans social feeding by FMRFamide-related
peptide activation of NPR-1. Nature Neuroscience. Springer Nature. https://doi.org/10.1038/nn1140
chicago: Rogers, Candida, Vincenzina Reale, Kyuhyung Kim, Heather Chatwin, Chris
Li, Peter Evans, and Mario de Bono. “Inhibition of Caenorhabditis Elegans Social
Feeding by FMRFamide-Related Peptide Activation of NPR-1.” Nature Neuroscience.
Springer Nature, 2003. https://doi.org/10.1038/nn1140.
ieee: C. Rogers et al., “Inhibition of Caenorhabditis elegans social feeding
by FMRFamide-related peptide activation of NPR-1,” Nature Neuroscience,
vol. 6, no. 11. Springer Nature, pp. 1178–1185, 2003.
ista: Rogers C, Reale V, Kim K, Chatwin H, Li C, Evans P, de Bono M. 2003. Inhibition
of Caenorhabditis elegans social feeding by FMRFamide-related peptide activation
of NPR-1. Nature Neuroscience. 6(11), 1178–1185.
mla: Rogers, Candida, et al. “Inhibition of Caenorhabditis Elegans Social Feeding
by FMRFamide-Related Peptide Activation of NPR-1.” Nature Neuroscience,
vol. 6, no. 11, Springer Nature, 2003, pp. 1178–85, doi:10.1038/nn1140.
short: C. Rogers, V. Reale, K. Kim, H. Chatwin, C. Li, P. Evans, M. de Bono, Nature
Neuroscience 6 (2003) 1178–1185.
date_created: 2019-03-21T09:47:53Z
date_published: 2003-10-12T00:00:00Z
date_updated: 2021-01-12T08:06:25Z
day: '12'
doi: 10.1038/nn1140
extern: '1'
external_id:
pmid:
- '14555955'
intvolume: ' 6'
issue: '11'
language:
- iso: eng
month: '10'
oa_version: None
page: 1178-1185
pmid: 1
publication: Nature Neuroscience
publication_identifier:
issn:
- 1097-6256
- 1546-1726
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Inhibition of Caenorhabditis elegans social feeding by FMRFamide-related peptide
activation of NPR-1
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 6
year: '2003'
...
---
_id: '6157'
abstract:
- lang: eng
text: In many animal species individuals aggregate to live in groups. A range of
experimental approaches in different animals, including studies of social feeding
in nematodes, maternal behavior in rats and sheep, and pair-bonding in voles,
are providing insights into the neural bases for these behaviors. These studies
are delineating multiple neural circuits and gene networks in the brain that interact
in ways that are as yet poorly understood to coordinate social behavior.
author:
- first_name: Mario
full_name: de Bono, Mario
id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
last_name: de Bono
orcid: 0000-0001-8347-0443
citation:
ama: de Bono M. Molecular approaches to aggregation behavior and social attachment.
Journal of Neurobiology. 2003;54(1):78-92. doi:10.1002/neu.10162
apa: de Bono, M. (2003). Molecular approaches to aggregation behavior and social
attachment. Journal of Neurobiology. Wiley. https://doi.org/10.1002/neu.10162
chicago: Bono, Mario de. “Molecular Approaches to Aggregation Behavior and Social
Attachment.” Journal of Neurobiology. Wiley, 2003. https://doi.org/10.1002/neu.10162.
ieee: M. de Bono, “Molecular approaches to aggregation behavior and social attachment,”
Journal of Neurobiology, vol. 54, no. 1. Wiley, pp. 78–92, 2003.
ista: de Bono M. 2003. Molecular approaches to aggregation behavior and social attachment.
Journal of Neurobiology. 54(1), 78–92.
mla: de Bono, Mario. “Molecular Approaches to Aggregation Behavior and Social Attachment.”
Journal of Neurobiology, vol. 54, no. 1, Wiley, 2003, pp. 78–92, doi:10.1002/neu.10162.
short: M. de Bono, Journal of Neurobiology 54 (2003) 78–92.
date_created: 2019-03-21T09:52:31Z
date_published: 2003-01-01T00:00:00Z
date_updated: 2021-01-12T08:06:26Z
day: '01'
doi: 10.1002/neu.10162
extern: '1'
external_id:
pmid:
- '12486699'
intvolume: ' 54'
issue: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 78-92
pmid: 1
publication: Journal of Neurobiology
publication_identifier:
issn:
- 0022-3034
- 1097-4695
publication_status: published
publisher: Wiley
quality_controlled: '1'
status: public
title: Molecular approaches to aggregation behavior and social attachment
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 54
year: '2003'
...
---
_id: '9455'
abstract:
- lang: eng
text: Proteins of the ARGONAUTE family are important in diverse posttranscriptional
RNA-mediated gene-silencing systems as well as in transcriptional gene silencing
in Drosophila and fission yeast and in programmed DNA elimination in Tetrahymena.
We cloned ARGONAUTE4 (AGO4) from a screen for mutants that suppress silencing
of the Arabidopsis SUPERMAN(SUP) gene. The ago4-1 mutant reactivated silentSUP
alleles and decreased CpNpG and asymmetric DNA methylation as well as histone
H3 lysine-9 methylation. In addition,ago4-1 blocked histone and DNA methylation
and the accumulation of 25-nucleotide small interfering RNAs (siRNAs) that correspond
to the retroelement AtSN1. These results suggest that AGO4 and long siRNAs direct
chromatin modifications, including histone methylation and non-CpG DNA methylation.
article_processing_charge: No
article_type: original
author:
- first_name: Daniel
full_name: Zilberman, Daniel
id: 6973db13-dd5f-11ea-814e-b3e5455e9ed1
last_name: Zilberman
orcid: 0000-0002-0123-8649
- first_name: ' Xiaofeng'
full_name: Cao, Xiaofeng
last_name: Cao
- first_name: Steven E.
full_name: Jacobsen, Steven E.
last_name: Jacobsen
citation:
ama: Zilberman D, Cao Xiaofeng, Jacobsen SE. ARGONAUTE4 control of locus-specific
siRNA accumulation and DNA and histone methylation. Science. 2003;299(5607):716-719.
doi:10.1126/science.1079695
apa: Zilberman, D., Cao, Xiaofeng, & Jacobsen, S. E. (2003). ARGONAUTE4 control
of locus-specific siRNA accumulation and DNA and histone methylation. Science.
American Association for the Advancement of Science. https://doi.org/10.1126/science.1079695
chicago: Zilberman, Daniel, Xiaofeng Cao, and Steven E. Jacobsen. “ARGONAUTE4 Control
of Locus-Specific SiRNA Accumulation and DNA and Histone Methylation.” Science.
American Association for the Advancement of Science, 2003. https://doi.org/10.1126/science.1079695.
ieee: D. Zilberman, Xiaofeng Cao, and S. E. Jacobsen, “ARGONAUTE4 control of locus-specific
siRNA accumulation and DNA and histone methylation,” Science, vol. 299,
no. 5607. American Association for the Advancement of Science, pp. 716–719, 2003.
ista: Zilberman D, Cao Xiaofeng, Jacobsen SE. 2003. ARGONAUTE4 control of locus-specific
siRNA accumulation and DNA and histone methylation. Science. 299(5607), 716–719.
mla: Zilberman, Daniel, et al. “ARGONAUTE4 Control of Locus-Specific SiRNA Accumulation
and DNA and Histone Methylation.” Science, vol. 299, no. 5607, American
Association for the Advancement of Science, 2003, pp. 716–19, doi:10.1126/science.1079695.
short: D. Zilberman, Xiaofeng Cao, S.E. Jacobsen, Science 299 (2003) 716–719.
date_created: 2021-06-04T11:26:26Z
date_published: 2003-01-31T00:00:00Z
date_updated: 2021-12-14T08:43:30Z
day: '31'
department:
- _id: DaZi
doi: 10.1126/science.1079695
extern: '1'
external_id:
pmid:
- '12522258'
intvolume: ' 299'
issue: '5607'
keyword:
- Multidisciplinary
language:
- iso: eng
month: '01'
oa_version: None
page: 716-719
pmid: 1
publication: Science
publication_identifier:
eissn:
- 1095-9203
issn:
- 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone
methylation
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 299
year: '2003'
...
---
_id: '9495'
abstract:
- lang: eng
text: RNA interference is a conserved process in which double-stranded RNA is processed
into 21–25 nucleotide siRNAs that trigger posttranscriptional gene silencing.
In addition, plants display a phenomenon termed RNA-directed DNA methylation (RdDM)
in which DNA with sequence identity to silenced RNA is de novo methylated at its
cytosine residues. This methylation is not only at canonical CpG sites but also
at cytosines in CpNpG and asymmetric sequence contexts. In this report, we study
the role of the DRM and CMT3 DNA methyltransferase genes in the initiation and
maintenance of RdDM. Neither drm nor cmt3 mutants affected the maintenance of
preestablished RNA-directed CpG methylation. However, drm mutants showed a nearly
complete loss of asymmetric methylation and a partial loss of CpNpG methylation.
The remaining asymmetric and CpNpG methylation was dependent on the activity of
CMT3, showing that DRM and CMT3 act redundantly to maintain non-CpG methylation.
These DNA methyltransferases appear to act downstream of siRNAs, since drm1 drm2
cmt3 triple mutants show a lack of non-CpG methylation but elevated levels of
siRNAs. Finally, we demonstrate that DRM activity is required for the initial
establishment of RdDM in all sequence contexts including CpG, CpNpG, and asymmetric
sites.
article_processing_charge: No
article_type: original
author:
- first_name: Xiaofeng
full_name: Cao, Xiaofeng
last_name: Cao
- first_name: Werner
full_name: Aufsatz, Werner
last_name: Aufsatz
- first_name: Daniel
full_name: Zilberman, Daniel
id: 6973db13-dd5f-11ea-814e-b3e5455e9ed1
last_name: Zilberman
orcid: 0000-0002-0123-8649
- first_name: M.Florian
full_name: Mette, M.Florian
last_name: Mette
- first_name: Michael S.
full_name: Huang, Michael S.
last_name: Huang
- first_name: Marjori
full_name: Matzke, Marjori
last_name: Matzke
- first_name: Steven E.
full_name: Jacobsen, Steven E.
last_name: Jacobsen
citation:
ama: Cao X, Aufsatz W, Zilberman D, et al. Role of the DRM and CMT3 methyltransferases
in RNA-directed DNA methylation. Current Biology. 2003;13(24):2212-2217.
doi:10.1016/j.cub.2003.11.052
apa: Cao, X., Aufsatz, W., Zilberman, D., Mette, M. F., Huang, M. S., Matzke, M.,
& Jacobsen, S. E. (2003). Role of the DRM and CMT3 methyltransferases in RNA-directed
DNA methylation. Current Biology. Elsevier. https://doi.org/10.1016/j.cub.2003.11.052
chicago: Cao, Xiaofeng, Werner Aufsatz, Daniel Zilberman, M.Florian Mette, Michael
S. Huang, Marjori Matzke, and Steven E. Jacobsen. “Role of the DRM and CMT3 Methyltransferases
in RNA-Directed DNA Methylation.” Current Biology. Elsevier, 2003. https://doi.org/10.1016/j.cub.2003.11.052.
ieee: X. Cao et al., “Role of the DRM and CMT3 methyltransferases in RNA-directed
DNA methylation,” Current Biology, vol. 13, no. 24. Elsevier, pp. 2212–2217,
2003.
ista: Cao X, Aufsatz W, Zilberman D, Mette MF, Huang MS, Matzke M, Jacobsen SE.
2003. Role of the DRM and CMT3 methyltransferases in RNA-directed DNA methylation.
Current Biology. 13(24), 2212–2217.
mla: Cao, Xiaofeng, et al. “Role of the DRM and CMT3 Methyltransferases in RNA-Directed
DNA Methylation.” Current Biology, vol. 13, no. 24, Elsevier, 2003, pp.
2212–17, doi:10.1016/j.cub.2003.11.052.
short: X. Cao, W. Aufsatz, D. Zilberman, M.F. Mette, M.S. Huang, M. Matzke, S.E.
Jacobsen, Current Biology 13 (2003) 2212–2217.
date_created: 2021-06-07T10:43:02Z
date_published: 2003-12-16T00:00:00Z
date_updated: 2021-12-14T08:41:38Z
day: '16'
department:
- _id: DaZi
doi: 10.1016/j.cub.2003.11.052
extern: '1'
external_id:
pmid:
- '14680640'
intvolume: ' 13'
issue: '24'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.cub.2003.11.052
month: '12'
oa: 1
oa_version: Published Version
page: 2212-2217
pmid: 1
publication: Current Biology
publication_identifier:
eissn:
- 1879-0445
issn:
- 0960-9822
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Role of the DRM and CMT3 methyltransferases in RNA-directed DNA methylation
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 13
year: '2003'
...
---
_id: '11121'
abstract:
- lang: eng
text: In metazoa, the nuclear envelope breaks down and reforms during each cell
cycle. Nuclear pore complexes (NPCs), which serve as channels for transport between
the nucleus and cytoplasm1, assemble into the reforming nuclear envelope in a
sequential process involving association of a subset of NPC proteins, nucleoporins,
with chromatin followed by the formation of a closed nuclear envelope fenestrated
by NPCs2,3,4,5,6,7. How chromatin recruitment of nucleoporins and NPC assembly
are regulated is unknown. Here we demonstrate that RanGTP production is required
to dissociate nucleoporins Nup107, Nup153 and Nup358 from Importin β, to target
them to chromatin and to induce association between separate NPC subcomplexes.
Additionally, either an excess of RanGTP or removal of Importin β induces formation
of NPC-containing membrane structures—annulate lamellae—both in vitro in the absence
of chromatin and in vivo. Annulate lamellae formation is strongly and specifically
inhibited by an excess of Importin β. The data demonstrate that RanGTP triggers
distinct steps of NPC assembly, and suggest a mechanism for the spatial restriction
of NPC assembly to the surface of chromatin.
article_processing_charge: No
article_type: original
author:
- first_name: Tobias C.
full_name: Walther, Tobias C.
last_name: Walther
- first_name: Peter
full_name: Askjaer, Peter
last_name: Askjaer
- first_name: Marc
full_name: Gentzel, Marc
last_name: Gentzel
- first_name: Anja
full_name: Habermann, Anja
last_name: Habermann
- first_name: Gareth
full_name: Griffiths, Gareth
last_name: Griffiths
- first_name: Matthias
full_name: Wilm, Matthias
last_name: Wilm
- first_name: Iain W.
full_name: Mattaj, Iain W.
last_name: Mattaj
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
citation:
ama: Walther TC, Askjaer P, Gentzel M, et al. RanGTP mediates nuclear pore complex
assembly. Nature. 2003;424(6949):689-694. doi:10.1038/nature01898
apa: Walther, T. C., Askjaer, P., Gentzel, M., Habermann, A., Griffiths, G., Wilm,
M., … Hetzer, M. (2003). RanGTP mediates nuclear pore complex assembly. Nature.
Springer Nature. https://doi.org/10.1038/nature01898
chicago: Walther, Tobias C., Peter Askjaer, Marc Gentzel, Anja Habermann, Gareth
Griffiths, Matthias Wilm, Iain W. Mattaj, and Martin Hetzer. “RanGTP Mediates
Nuclear Pore Complex Assembly.” Nature. Springer Nature, 2003. https://doi.org/10.1038/nature01898.
ieee: T. C. Walther et al., “RanGTP mediates nuclear pore complex assembly,”
Nature, vol. 424, no. 6949. Springer Nature, pp. 689–694, 2003.
ista: Walther TC, Askjaer P, Gentzel M, Habermann A, Griffiths G, Wilm M, Mattaj
IW, Hetzer M. 2003. RanGTP mediates nuclear pore complex assembly. Nature. 424(6949),
689–694.
mla: Walther, Tobias C., et al. “RanGTP Mediates Nuclear Pore Complex Assembly.”
Nature, vol. 424, no. 6949, Springer Nature, 2003, pp. 689–94, doi:10.1038/nature01898.
short: T.C. Walther, P. Askjaer, M. Gentzel, A. Habermann, G. Griffiths, M. Wilm,
I.W. Mattaj, M. Hetzer, Nature 424 (2003) 689–694.
date_created: 2022-04-07T07:57:02Z
date_published: 2003-07-30T00:00:00Z
date_updated: 2022-07-18T08:57:40Z
day: '30'
doi: 10.1038/nature01898
extern: '1'
external_id:
pmid:
- '12894213'
intvolume: ' 424'
issue: '6949'
keyword:
- Multidisciplinary
language:
- iso: eng
month: '07'
oa_version: None
page: 689-694
pmid: 1
publication: Nature
publication_identifier:
eissn:
- 1476-4687
issn:
- 0028-0836
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: RanGTP mediates nuclear pore complex assembly
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 424
year: '2003'
...
---
_id: '11122'
abstract:
- lang: eng
text: Nuclear pore complexes (NPCs) are large multiprotein assemblies that allow
traffic between the cytoplasm and the nucleus. During mitosis in higher eukaryotes,
the Nuclear Envelope (NE) breaks down and NPCs disassemble. How NPCs reassemble
and incorporate into the NE upon mitotic exit is poorly understood. We demonstrate
a function for the conserved Nup107-160 complex in this process. Partial in vivo
depletion of Nup133 or Nup107 via RNAi in HeLa cells resulted in reduced levels
of multiple nucleoporins and decreased NPC density in the NE. Immunodepletion
of the entire Nup107-160 complex from in vitro nuclear assembly reactions produced
nuclei with a continuous NE but no NPCs. This phenotype was reversible only if
Nup107-160 complex was readded before closed NE formation. Depletion also prevented
association of FG-repeat nucleoporins with chromatin. We propose a stepwise model
in which postmitotic NPC assembly initiates on chromatin via early recruitment
of the Nup107-160 complex.
article_processing_charge: No
article_type: original
author:
- first_name: Tobias C.
full_name: Walther, Tobias C.
last_name: Walther
- first_name: Annabelle
full_name: Alves, Annabelle
last_name: Alves
- first_name: Helen
full_name: Pickersgill, Helen
last_name: Pickersgill
- first_name: Isabelle
full_name: Loı̈odice, Isabelle
last_name: Loı̈odice
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
- first_name: Vincent
full_name: Galy, Vincent
last_name: Galy
- first_name: Bastian B.
full_name: Hülsmann, Bastian B.
last_name: Hülsmann
- first_name: Thomas
full_name: Köcher, Thomas
last_name: Köcher
- first_name: Matthias
full_name: Wilm, Matthias
last_name: Wilm
- first_name: Terry
full_name: Allen, Terry
last_name: Allen
- first_name: Iain W.
full_name: Mattaj, Iain W.
last_name: Mattaj
- first_name: Valérie
full_name: Doye, Valérie
last_name: Doye
citation:
ama: Walther TC, Alves A, Pickersgill H, et al. The conserved Nup107-160 complex
is critical for nuclear pore complex assembly. Cell. 2003;113(2):195-206.
doi:10.1016/s0092-8674(03)00235-6
apa: Walther, T. C., Alves, A., Pickersgill, H., Loı̈odice, I., Hetzer, M., Galy,
V., … Doye, V. (2003). The conserved Nup107-160 complex is critical for nuclear
pore complex assembly. Cell. Elsevier. https://doi.org/10.1016/s0092-8674(03)00235-6
chicago: Walther, Tobias C., Annabelle Alves, Helen Pickersgill, Isabelle Loı̈odice,
Martin Hetzer, Vincent Galy, Bastian B. Hülsmann, et al. “The Conserved Nup107-160
Complex Is Critical for Nuclear Pore Complex Assembly.” Cell. Elsevier,
2003. https://doi.org/10.1016/s0092-8674(03)00235-6.
ieee: T. C. Walther et al., “The conserved Nup107-160 complex is critical
for nuclear pore complex assembly,” Cell, vol. 113, no. 2. Elsevier, pp.
195–206, 2003.
ista: Walther TC, Alves A, Pickersgill H, Loı̈odice I, Hetzer M, Galy V, Hülsmann
BB, Köcher T, Wilm M, Allen T, Mattaj IW, Doye V. 2003. The conserved Nup107-160
complex is critical for nuclear pore complex assembly. Cell. 113(2), 195–206.
mla: Walther, Tobias C., et al. “The Conserved Nup107-160 Complex Is Critical for
Nuclear Pore Complex Assembly.” Cell, vol. 113, no. 2, Elsevier, 2003,
pp. 195–206, doi:10.1016/s0092-8674(03)00235-6.
short: T.C. Walther, A. Alves, H. Pickersgill, I. Loı̈odice, M. Hetzer, V. Galy,
B.B. Hülsmann, T. Köcher, M. Wilm, T. Allen, I.W. Mattaj, V. Doye, Cell 113 (2003)
195–206.
date_created: 2022-04-07T07:57:10Z
date_published: 2003-04-17T00:00:00Z
date_updated: 2022-07-18T08:57:42Z
day: '17'
doi: 10.1016/s0092-8674(03)00235-6
extern: '1'
external_id:
pmid:
- '12705868'
intvolume: ' 113'
issue: '2'
keyword:
- General Biochemistry
- Genetics and Molecular Biology
language:
- iso: eng
month: '04'
oa_version: Published Version
page: 195-206
pmid: 1
publication: Cell
publication_identifier:
issn:
- 0092-8674
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: The conserved Nup107-160 complex is critical for nuclear pore complex assembly
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 113
year: '2003'
...
---
_id: '11764'
abstract:
- lang: eng
text: In this paper we consider the online ftp problem. The goal is to service a
sequence of file transfer requests given bandwidth constraints of the underlying
communication network. The main result of the paper is a technique that leads
to algorithms that optimize several natural metrics, such as max-stretch, total
flow time, max flow time, and total completion time. In particular, we show how
to achieve optimum total flow time and optimum max-stretch if we increase the
capacity of the underlying network by a logarithmic factor. We show that the resource
augmentation is necessary by proving polynomial lower bounds on the max-stretch
and total flow time for the case where online and offline algorithms are using
same-capacity edges. Moreover, we also give polylogarithmic lower bounds on the
resource augmentation factor necessary in order to keep the total flow time and
max-stretch within a constant factor of optimum.
article_processing_charge: No
article_type: original
author:
- first_name: Ashish
full_name: Goel, Ashish
last_name: Goel
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Serge
full_name: Plotkin, Serge
last_name: Plotkin
- first_name: Eva
full_name: Tardos, Eva
last_name: Tardos
citation:
ama: Goel A, Henzinger MH, Plotkin S, Tardos E. Scheduling data transfers in a network
and the set scheduling problem. Journal of Algorithms. 2003;48(2):314-332.
doi:10.1016/s0196-6774(03)00054-3
apa: Goel, A., Henzinger, M. H., Plotkin, S., & Tardos, E. (2003). Scheduling
data transfers in a network and the set scheduling problem. Journal of Algorithms.
Elsevier. https://doi.org/10.1016/s0196-6774(03)00054-3
chicago: Goel, Ashish, Monika H Henzinger, Serge Plotkin, and Eva Tardos. “Scheduling
Data Transfers in a Network and the Set Scheduling Problem.” Journal of Algorithms.
Elsevier, 2003. https://doi.org/10.1016/s0196-6774(03)00054-3.
ieee: A. Goel, M. H. Henzinger, S. Plotkin, and E. Tardos, “Scheduling data transfers
in a network and the set scheduling problem,” Journal of Algorithms, vol.
48, no. 2. Elsevier, pp. 314–332, 2003.
ista: Goel A, Henzinger MH, Plotkin S, Tardos E. 2003. Scheduling data transfers
in a network and the set scheduling problem. Journal of Algorithms. 48(2), 314–332.
mla: Goel, Ashish, et al. “Scheduling Data Transfers in a Network and the Set Scheduling
Problem.” Journal of Algorithms, vol. 48, no. 2, Elsevier, 2003, pp. 314–32,
doi:10.1016/s0196-6774(03)00054-3.
short: A. Goel, M.H. Henzinger, S. Plotkin, E. Tardos, Journal of Algorithms 48
(2003) 314–332.
date_created: 2022-08-08T12:09:32Z
date_published: 2003-09-01T00:00:00Z
date_updated: 2022-09-12T09:45:06Z
day: '01'
doi: 10.1016/s0196-6774(03)00054-3
extern: '1'
intvolume: ' 48'
issue: '2'
language:
- iso: eng
month: '09'
oa_version: None
page: 314-332
publication: Journal of Algorithms
publication_identifier:
issn:
- 0196-6774
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Scheduling data transfers in a network and the set scheduling problem
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 48
year: '2003'
...