[{"language":[{"iso":"eng"}],"oa_version":"None","month":"02","publication":"Journal of Neuroscience","status":"public","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publication_identifier":{"issn":["0270-6474"]},"publist_id":"4285","date_published":"2002-02-15T00:00:00Z","type":"journal_article","publisher":"Society for Neuroscience","article_type":"original","page":"1280 - 1289","quality_controlled":"1","publication_status":"published","article_processing_charge":"No","date_created":"2018-12-11T11:58:40Z","title":"Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins","intvolume":"        22","_id":"2613","pmid":1,"scopus_import":"1","author":[{"last_name":"Kitano","first_name":"Jun","full_name":"Kitano, Jun"},{"last_name":"Kimura","first_name":"Kouji","full_name":"Kimura, Kouji"},{"last_name":"Yamazaki","first_name":"Yoshimitsu","full_name":"Yamazaki, Yoshimitsu"},{"last_name":"Soda","first_name":"Takeshi","full_name":"Soda, Takeshi"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi","first_name":"Ryuichi","last_name":"Shigemoto"},{"last_name":"Nakajima","first_name":"Yoshiaki","full_name":"Nakajima, Yoshiaki"},{"last_name":"Nakanishi","first_name":"Shigetada","full_name":"Nakanishi, Shigetada"}],"issue":"4","volume":22,"acknowledgement":"This work was supported in part by research grants from the Ministry of Education, Science and Culture of Japan. We thank Bert Vogelstein for providing adenoviral recombination vectors and Haruhiko Bito for a gift of the enolase promoter and technical advice. We are grateful to Atsushi Nishimune and Satoshi Kaneko for technical advice and Kumlesh K. Dev for careful reading of this manuscript.","extern":"1","doi":"10.1523/JNEUROSCI.22-04-01280.2002","day":"15","abstract":[{"text":"In this investigation, we report identification and characterization of a 95 kDa postsynaptic density protein (PSD-95)/discs-large/ ZO-1 (PDZ) domain-containing protein termed tamalin, also recently named GRP1-associated scaffold protein (GRASP), that interacts with group 1 metabotropic glutamate receptors (mGluRs). The yeast two-hybrid system and in vitro pull-down assays indicated that the PDZ domain-containing, amino-terminal half of tamalin directly binds to the class I PDZ-binding motif of group 1 mGluRs. The C-terminal half of tamalin also bound to cytohesins, the members of guanine nucleotide exchange factors (GEFs) specific for the ADP-ribosylation factor (ARF) family of small GTP-binding proteins. Tamalin mRNA is expressed predominantly in the telencephalic region and highly overlaps with the expression of group 1 mGluR mRNAs. Both tamalin and cytohesin-2 were enriched and codistributed with mGluR1a in postsynaptic membrane fractions. Importantly, recombinant and native mGluR1a/tamalin/cytohesin-2 complexes were coimmunoprecipitated from transfected COS-7 cells and rat brain tissue, respectively. Transfection of tamalin and mutant tamalin lacking a cytohesin-binding domain caused an increase and decrease in cell-surface expression of mGluR1a in COS-7 cells, respectively. Furthermore, adenovirus-mediated expression of tamalin and dominant-negative tamalin facilitated and reduced the neuritic distribution of endogenous mGluR5 in cultured hippocampal neurons, respectively. The results indicate that tamalin plays a key role in the association of group 1 mGluRs with the ARF-specific GEF proteins and contributes to intracellular trafficking and the macromolecular organization of group 1 mGluRs at synapses.","lang":"eng"}],"date_updated":"2023-07-25T11:34:46Z","year":"2002","citation":{"ieee":"J. Kitano <i>et al.</i>, “Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins,” <i>Journal of Neuroscience</i>, vol. 22, no. 4. Society for Neuroscience, pp. 1280–1289, 2002.","chicago":"Kitano, Jun, Kouji Kimura, Yoshimitsu Yamazaki, Takeshi Soda, Ryuichi Shigemoto, Yoshiaki Nakajima, and Shigetada Nakanishi. “Tamalin, a PDZ Domain-Containing Protein, Links a Protein Complex Formation of Group 1 Metabotropic Glutamate Receptors and the Guanine Nucleotide Exchange Factor Cytohesins.” <i>Journal of Neuroscience</i>. Society for Neuroscience, 2002. <a href=\"https://doi.org/10.1523/JNEUROSCI.22-04-01280.2002\">https://doi.org/10.1523/JNEUROSCI.22-04-01280.2002</a>.","ama":"Kitano J, Kimura K, Yamazaki Y, et al. Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins. <i>Journal of Neuroscience</i>. 2002;22(4):1280-1289. doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.22-04-01280.2002\">10.1523/JNEUROSCI.22-04-01280.2002</a>","apa":"Kitano, J., Kimura, K., Yamazaki, Y., Soda, T., Shigemoto, R., Nakajima, Y., &#38; Nakanishi, S. (2002). Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins. <i>Journal of Neuroscience</i>. Society for Neuroscience. <a href=\"https://doi.org/10.1523/JNEUROSCI.22-04-01280.2002\">https://doi.org/10.1523/JNEUROSCI.22-04-01280.2002</a>","ista":"Kitano J, Kimura K, Yamazaki Y, Soda T, Shigemoto R, Nakajima Y, Nakanishi S. 2002. Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins. Journal of Neuroscience. 22(4), 1280–1289.","mla":"Kitano, Jun, et al. “Tamalin, a PDZ Domain-Containing Protein, Links a Protein Complex Formation of Group 1 Metabotropic Glutamate Receptors and the Guanine Nucleotide Exchange Factor Cytohesins.” <i>Journal of Neuroscience</i>, vol. 22, no. 4, Society for Neuroscience, 2002, pp. 1280–89, doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.22-04-01280.2002\">10.1523/JNEUROSCI.22-04-01280.2002</a>.","short":"J. Kitano, K. Kimura, Y. Yamazaki, T. Soda, R. Shigemoto, Y. Nakajima, S. Nakanishi, Journal of Neuroscience 22 (2002) 1280–1289."},"external_id":{"pmid":["11850456"]}},{"abstract":[{"lang":"eng","text":"Metabotropic glutamate receptors (mGluRs) from group III reduce glutamate release. Because these receptors reduce cAMP levels, we explored whether this signaling pathway contributes to release inhibition caused by mGluRs with low affinity for L-2-amino-4-phosphonobutyrate (L-AP4). In biochemical experiments with the population of cerebrocortical nerve terminals we find that L-AP4 (1 mM) inhibited the Ca2+dependent-evoked release of glutamate by 25%. This inhibitory effect was largely prevented by the pertussis toxin but was insensitive to inhibitors of protein kinase C bisindolylmaleimide and protein kinase A H-89. Furthermore, this inhibition was associated with reduction in N-type Ca2+ channel activity in the absence of any detectable change in cAMP levels. In the presence of forskolin, however, L-AP4 decreased the levels of cAMP. The activation of this additional signaling pathway was very efficient in counteracting the facilitation of glutamate release induced either by forskolin or the β-adrenergic receptor agonist isoproterenol. Imaging experiments to measure Ca2+ dynamics in single nerve terminals showed that L-AP4 strongly reduced the Ca2+ response in 28% of the nerve terminals. Moreover, immunochemical experiments showed that 25-35% of the nerve terminals that were immunopositive to synaptophysin were also immunoreactive to the low affinity L-AP4-sensitive mGluR7. Then, mGluR7 mediates the inhibition of glutamate release caused by 1 mM L-AP4, primarily by a strong inhibition of Ca2+ channels, although high cAMP uncovers the receptor ability to decrease cAMP."}],"day":"19","doi":"10.1074/jbc.M109044200","external_id":{"pmid":["11825890"]},"citation":{"apa":"Millán, C., Luján, R., Shigemoto, R., &#38; Sánchez Prieto, J. (2002). The inhibition of glutamate release by metabotropic glutamate receptor 7 affects both [Ca2+]c and cAMP. Evidence for a strong reduction of Ca2+ entry in single nerve terminals. <i>Journal of Biological Chemistry</i>. American Society for Biochemistry and Molecular Biology. <a href=\"https://doi.org/10.1074/jbc.M109044200\">https://doi.org/10.1074/jbc.M109044200</a>","ama":"Millán C, Luján R, Shigemoto R, Sánchez Prieto J. The inhibition of glutamate release by metabotropic glutamate receptor 7 affects both [Ca2+]c and cAMP. Evidence for a strong reduction of Ca2+ entry in single nerve terminals. <i>Journal of Biological Chemistry</i>. 2002;277(16):14092-14101. doi:<a href=\"https://doi.org/10.1074/jbc.M109044200\">10.1074/jbc.M109044200</a>","ieee":"C. Millán, R. Luján, R. Shigemoto, and J. Sánchez Prieto, “The inhibition of glutamate release by metabotropic glutamate receptor 7 affects both [Ca2+]c and cAMP. Evidence for a strong reduction of Ca2+ entry in single nerve terminals,” <i>Journal of Biological Chemistry</i>, vol. 277, no. 16. American Society for Biochemistry and Molecular Biology, pp. 14092–14101, 2002.","chicago":"Millán, Carmelo, Rafael Luján, Ryuichi Shigemoto, and José Sánchez Prieto. “The Inhibition of Glutamate Release by Metabotropic Glutamate Receptor 7 Affects Both [Ca2+]c and CAMP. Evidence for a Strong Reduction of Ca2+ Entry in Single Nerve Terminals.” <i>Journal of Biological Chemistry</i>. American Society for Biochemistry and Molecular Biology, 2002. <a href=\"https://doi.org/10.1074/jbc.M109044200\">https://doi.org/10.1074/jbc.M109044200</a>.","short":"C. Millán, R. Luján, R. Shigemoto, J. Sánchez Prieto, Journal of Biological Chemistry 277 (2002) 14092–14101.","mla":"Millán, Carmelo, et al. “The Inhibition of Glutamate Release by Metabotropic Glutamate Receptor 7 Affects Both [Ca2+]c and CAMP. Evidence for a Strong Reduction of Ca2+ Entry in Single Nerve Terminals.” <i>Journal of Biological Chemistry</i>, vol. 277, no. 16, American Society for Biochemistry and Molecular Biology, 2002, pp. 14092–101, doi:<a href=\"https://doi.org/10.1074/jbc.M109044200\">10.1074/jbc.M109044200</a>.","ista":"Millán C, Luján R, Shigemoto R, Sánchez Prieto J. 2002. The inhibition of glutamate release by metabotropic glutamate receptor 7 affects both [Ca2+]c and cAMP. Evidence for a strong reduction of Ca2+ entry in single nerve terminals. Journal of Biological Chemistry. 277(16), 14092–14101."},"year":"2002","date_updated":"2023-07-25T10:16:44Z","ddc":["570"],"extern":"1","acknowledgement":"We thank Dr. Enrique Castro from Las Palmas University for critical reading of the manuscript and M. Sefton for editorial assistance.","volume":277,"intvolume":"       277","title":"The inhibition of glutamate release by metabotropic glutamate receptor 7 affects both [Ca2+]c and cAMP. Evidence for a strong reduction of Ca2+ entry in single nerve terminals","article_processing_charge":"No","date_created":"2018-12-11T11:58:41Z","publication_status":"published","issue":"16","author":[{"last_name":"Millán","first_name":"Carmelo","full_name":"Millán, Carmelo"},{"full_name":"Luján, Rafael","first_name":"Rafael","last_name":"Luján"},{"orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi","first_name":"Ryuichi","last_name":"Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Sánchez Prieto, José","first_name":"José","last_name":"Sánchez Prieto"}],"scopus_import":"1","_id":"2614","pmid":1,"article_type":"original","publisher":"American Society for Biochemistry and Molecular Biology","file_date_updated":"2023-07-25T10:13:16Z","quality_controlled":"1","page":"14092 - 14101","publist_id":"4284","oa":1,"publication_identifier":{"issn":["0021-9258"]},"type":"journal_article","date_published":"2002-04-19T00:00:00Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","status":"public","file":[{"file_id":"13309","creator":"alisjak","success":1,"access_level":"open_access","relation":"main_file","date_updated":"2023-07-25T10:13:16Z","content_type":"application/pdf","file_name":"2002_JBC_Millan.pdf","date_created":"2023-07-25T10:13:16Z","file_size":2105520,"checksum":"0290fcbbd9153ec654185b0c856f214c"}],"month":"04","oa_version":"Published Version","has_accepted_license":"1","publication":"Journal of Biological Chemistry","language":[{"iso":"eng"}]},{"extern":"1","volume":65,"abstract":[{"text":"Taste-mGluR4, cloned from taste tissues, is a truncated variant of brain-expressed mGluR4a (brain-mGluR4), and is known to be a candidate for the receptor involved in the umami taste sense. Although the expression patterns of taste- and brain-mGluR4 mRNAs have been demonstrated, no mention has so far been made of the expression of these two mGluR4 proteins in taste tissues. The present study examined the expression of taste-mGluR4 and brain-mGluR4 proteins in rat taste tissues by using a specific antibody for mGluR4a which shared a C-terminus of both taste- and brain-mGluR4, for immunoblot analysis and immunohistochemistry. Immunoblot analysis showed that both brain-mGluR4 and taste-mGluR4 were expressed in the taste tissues. Taste-mGluR4 was not detected in the cerebellum. The immunoreactive band for brain-mGluR4 protein was much stronger than that for taste-mGluR4 protein. In the cryosections of fungiform, foliate and circumvallate papillae, the antibody against taste-mGluR4 exhibited intense labeling of the taste pores and taste hairs in all the taste buds of gustatory papillae examined; the immunoreaction to the antibody against brain-mGluR4 was more intense at the same sites of the taste buds. The portions of the taste bud cells below the taste pore and surrounding keratinocytes did not show any immunoreactivities. The results of the present study strongly suggest that, in addition to taste-mGluR4, brain-mGluR4 may function even more importantly than the former as a receptor for glutamate, i.e. the umami taste sensation.","lang":"eng"}],"doi":"10.1679/aohc.65.91","day":"01","external_id":{"pmid":["12002614"]},"date_updated":"2023-07-25T10:00:15Z","citation":{"ieee":"T. Toyono <i>et al.</i>, “Expression of the metabotropic glutamate receptor, mGluR4a, in the taste hairs of taste buds in rat gustatory papillae,” <i>Archives of Histology and Cytology</i>, vol. 65, no. 1. Japan Society of Histological Documentation, pp. 91–96, 2002.","chicago":"Toyono, Takashi, Yuji Seta, Shinji Sataoka, Harumi Harada, Takahiko Morotomi, Shintaro Kawano, Ryuichi Shigemoto, and Kuniaki Toyoshima. “Expression of the Metabotropic Glutamate Receptor, MGluR4a, in the Taste Hairs of Taste Buds in Rat Gustatory Papillae.” <i>Archives of Histology and Cytology</i>. Japan Society of Histological Documentation, 2002. <a href=\"https://doi.org/10.1679/aohc.65.91\">https://doi.org/10.1679/aohc.65.91</a>.","ama":"Toyono T, Seta Y, Sataoka S, et al. Expression of the metabotropic glutamate receptor, mGluR4a, in the taste hairs of taste buds in rat gustatory papillae. <i>Archives of Histology and Cytology</i>. 2002;65(1):91-96. doi:<a href=\"https://doi.org/10.1679/aohc.65.91\">10.1679/aohc.65.91</a>","apa":"Toyono, T., Seta, Y., Sataoka, S., Harada, H., Morotomi, T., Kawano, S., … Toyoshima, K. (2002). Expression of the metabotropic glutamate receptor, mGluR4a, in the taste hairs of taste buds in rat gustatory papillae. <i>Archives of Histology and Cytology</i>. Japan Society of Histological Documentation. <a href=\"https://doi.org/10.1679/aohc.65.91\">https://doi.org/10.1679/aohc.65.91</a>","ista":"Toyono T, Seta Y, Sataoka S, Harada H, Morotomi T, Kawano S, Shigemoto R, Toyoshima K. 2002. Expression of the metabotropic glutamate receptor, mGluR4a, in the taste hairs of taste buds in rat gustatory papillae. Archives of Histology and Cytology. 65(1), 91–96.","short":"T. Toyono, Y. Seta, S. Sataoka, H. Harada, T. Morotomi, S. Kawano, R. Shigemoto, K. Toyoshima, Archives of Histology and Cytology 65 (2002) 91–96.","mla":"Toyono, Takashi, et al. “Expression of the Metabotropic Glutamate Receptor, MGluR4a, in the Taste Hairs of Taste Buds in Rat Gustatory Papillae.” <i>Archives of Histology and Cytology</i>, vol. 65, no. 1, Japan Society of Histological Documentation, 2002, pp. 91–96, doi:<a href=\"https://doi.org/10.1679/aohc.65.91\">10.1679/aohc.65.91</a>."},"year":"2002","article_type":"original","publisher":"Japan Society of Histological Documentation","page":"91 - 96","quality_controlled":"1","title":"Expression of the metabotropic glutamate receptor, mGluR4a, in the taste hairs of taste buds in rat gustatory papillae","intvolume":"        65","publication_status":"published","article_processing_charge":"No","date_created":"2018-12-11T11:58:41Z","author":[{"last_name":"Toyono","first_name":"Takashi","full_name":"Toyono, Takashi"},{"last_name":"Seta","first_name":"Yuji","full_name":"Seta, Yuji"},{"full_name":"Sataoka, Shinji","first_name":"Shinji","last_name":"Sataoka"},{"full_name":"Harada, Harumi","orcid":"0000-0001-7429-7896","last_name":"Harada","first_name":"Harumi","id":"2E55CDF2-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Morotomi","first_name":"Takahiko","full_name":"Morotomi, Takahiko"},{"full_name":"Kawano, Shintaro","first_name":"Shintaro","last_name":"Kawano"},{"orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi","first_name":"Ryuichi","last_name":"Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Toyoshima, Kuniaki","first_name":"Kuniaki","last_name":"Toyoshima"}],"issue":"1","pmid":1,"_id":"2615","scopus_import":"1","status":"public","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publist_id":"4283","publication_identifier":{"issn":["0914-9465"]},"date_published":"2002-01-01T00:00:00Z","type":"journal_article","language":[{"iso":"eng"}],"month":"01","oa_version":"None","publication":"Archives of Histology and Cytology"},{"article_type":"original","publisher":"Oxford University Press","quality_controlled":"1","page":"625 - 638","intvolume":"        12","title":"Differential distribution of group I metabotropic glutamate receptors during rat cortical development","date_created":"2018-12-11T11:58:41Z","article_processing_charge":"No","publication_status":"published","issue":"6","author":[{"last_name":"López Bendito","first_name":"Guillermina","full_name":"López Bendito, Guillermina"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","first_name":"Ryuichi","full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444"},{"first_name":"Alfonso","last_name":"Fairén","full_name":"Fairén, Alfonso"},{"last_name":"Luján","first_name":"Rafael","full_name":"Luján, Rafael"}],"scopus_import":"1","_id":"2616","pmid":1,"extern":"1","volume":12,"acknowledgement":"The authors are grateful to Dr Ole Paulsen and Professor Kay Davies for their comments on the manuscript. We also would like to thank Dr Zoltan Molnar for his support and Mrs Lucy Jones, Ms Courtney Voelker and Mr David Dongworth for the English revision of the manuscript. This work was supported by grants from the European Community (QLG3-CT-1999-00192 to R.L.) and the Spanish Ministerio de Ciencia y Tecnología (PB97-0582-CO2-01 to A.F.).","abstract":[{"lang":"eng","text":"Neurons in the rat cerebral cortex are enriched in group I metabotropic glutamate receptor (mGluR) subtypes and respond to their activation during development. To understand better the mechanisms by which mGluR1 and mGluR5 mediate these effects, the goal of this study was to elucidate the expression pattern and to determine the cellular and the precise subcellular localization of these two receptor subtypes in the rat neocortex and hippocampus during late prenatal and postnatal development. At the light microscopic level, mGluR1 α and mGluR5 were first detected in the cerebral cortex with different expression levels at embryonic day E18. Thus, mGluR5 had a moderate expression, whereas mGluR1 α was detected as a diffuse and weak labeling. mGluR5 was localized in some Cajal-Retzius cells as well as in other cell types, such as pioneer neurons of the marginal zone. During postnatal development, the distribution of the receptors dramatically changed. From P0 to around P10, mGluR1α was localized in identified, transient Cajal-Retzius cells of neocortex and hippocampus, until these cells disappear. In addition, a population of interneurons localized the receptor from the second/third postnatal week. In contrast, mGluR5 was localized mainly in pyramidal cells and in some interneurons, with a neuropilar staining throughout the cerebral cortex. At the electron microscopic level, the immunoreactivity for both group I mGluR subtypes was expressed postsynaptically. Using immunogold methods, mGluR1α and mGluR5 immunoreactivities were found throughout postnatal development at the edge of postsynaptic specialization of asymmetrical synapses. These results show that the two group I mGluRs have a differential expression pattern in neocortex and hippocampus that may suggest roles for the receptors in the early processing of cortical information and in the control of cortical developmental events."}],"day":"01","doi":"10.1093/cercor/12.6.625","external_id":{"pmid":["12003862"]},"year":"2002","citation":{"short":"G. López Bendito, R. Shigemoto, A. Fairén, R. Luján, Cerebral Cortex 12 (2002) 625–638.","mla":"López Bendito, Guillermina, et al. “Differential Distribution of Group I Metabotropic Glutamate Receptors during Rat Cortical Development.” <i>Cerebral Cortex</i>, vol. 12, no. 6, Oxford University Press, 2002, pp. 625–38, doi:<a href=\"https://doi.org/10.1093/cercor/12.6.625\">10.1093/cercor/12.6.625</a>.","ista":"López Bendito G, Shigemoto R, Fairén A, Luján R. 2002. Differential distribution of group I metabotropic glutamate receptors during rat cortical development. Cerebral Cortex. 12(6), 625–638.","apa":"López Bendito, G., Shigemoto, R., Fairén, A., &#38; Luján, R. (2002). Differential distribution of group I metabotropic glutamate receptors during rat cortical development. <i>Cerebral Cortex</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/cercor/12.6.625\">https://doi.org/10.1093/cercor/12.6.625</a>","ama":"López Bendito G, Shigemoto R, Fairén A, Luján R. Differential distribution of group I metabotropic glutamate receptors during rat cortical development. <i>Cerebral Cortex</i>. 2002;12(6):625-638. doi:<a href=\"https://doi.org/10.1093/cercor/12.6.625\">10.1093/cercor/12.6.625</a>","chicago":"López Bendito, Guillermina, Ryuichi Shigemoto, Alfonso Fairén, and Rafael Luján. “Differential Distribution of Group I Metabotropic Glutamate Receptors during Rat Cortical Development.” <i>Cerebral Cortex</i>. Oxford University Press, 2002. <a href=\"https://doi.org/10.1093/cercor/12.6.625\">https://doi.org/10.1093/cercor/12.6.625</a>.","ieee":"G. López Bendito, R. Shigemoto, A. Fairén, and R. Luján, “Differential distribution of group I metabotropic glutamate receptors during rat cortical development,” <i>Cerebral Cortex</i>, vol. 12, no. 6. Oxford University Press, pp. 625–638, 2002."},"date_updated":"2023-07-25T09:54:10Z","language":[{"iso":"eng"}],"month":"06","oa_version":"None","publication":"Cerebral Cortex","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","status":"public","publist_id":"4282","publication_identifier":{"issn":["1047-3211"]},"type":"journal_article","date_published":"2002-06-01T00:00:00Z"},{"type":"journal_article","date_published":"2002-07-01T00:00:00Z","year":"2002","citation":{"chicago":"Losonczy, Attila, Limei Zhang, Ryuichi Shigemoto, Péter Somogyi, and Zoltán Nusser. “Cell Type Dependence and Variability in the Short-Term Plasticity of EPSCs in Identified Mouse Hippocampal Interneurones.” <i>Journal of Physiology</i>. Wiley-Blackwell, 2002. <a href=\"https://doi.org/10.1113/jphysiol.2002.020024\">https://doi.org/10.1113/jphysiol.2002.020024</a>.","ieee":"A. Losonczy, L. Zhang, R. Shigemoto, P. Somogyi, and Z. Nusser, “Cell type dependence and variability in the short-term plasticity of EPSCs in identified mouse hippocampal interneurones,” <i>Journal of Physiology</i>, vol. 542, no. 1. Wiley-Blackwell, pp. 193–210, 2002.","ama":"Losonczy A, Zhang L, Shigemoto R, Somogyi P, Nusser Z. Cell type dependence and variability in the short-term plasticity of EPSCs in identified mouse hippocampal interneurones. <i>Journal of Physiology</i>. 2002;542(1):193-210. doi:<a href=\"https://doi.org/10.1113/jphysiol.2002.020024\">10.1113/jphysiol.2002.020024</a>","apa":"Losonczy, A., Zhang, L., Shigemoto, R., Somogyi, P., &#38; Nusser, Z. (2002). Cell type dependence and variability in the short-term plasticity of EPSCs in identified mouse hippocampal interneurones. <i>Journal of Physiology</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1113/jphysiol.2002.020024\">https://doi.org/10.1113/jphysiol.2002.020024</a>","ista":"Losonczy A, Zhang L, Shigemoto R, Somogyi P, Nusser Z. 2002. Cell type dependence and variability in the short-term plasticity of EPSCs in identified mouse hippocampal interneurones. Journal of Physiology. 542(1), 193–210.","short":"A. Losonczy, L. Zhang, R. Shigemoto, P. Somogyi, Z. Nusser, Journal of Physiology 542 (2002) 193–210.","mla":"Losonczy, Attila, et al. “Cell Type Dependence and Variability in the Short-Term Plasticity of EPSCs in Identified Mouse Hippocampal Interneurones.” <i>Journal of Physiology</i>, vol. 542, no. 1, Wiley-Blackwell, 2002, pp. 193–210, doi:<a href=\"https://doi.org/10.1113/jphysiol.2002.020024\">10.1113/jphysiol.2002.020024</a>."},"date_updated":"2021-01-12T06:58:36Z","oa":1,"publist_id":"4281","abstract":[{"text":"Synapses exhibit different short-term plasticity patterns and this behaviour influences information processing in neuronal networks. We tested how the short-term plasticity of excitatory postsynaptic currents (EPSCs) depends on the postsynaptic cell type, identified by axonal arborizations and molecular markers in the hippocampal CA1 area. Three distinct types of short-term synaptic behaviour (facilitating, depressing and combined facilitating-depressing) were defined by fitting a dynamic neurotransmission model to the data. Approximately 75 % of the oriens-lacunosum-moleculare (O-LM) interneurones received facilitating EPSCs, but in three of 12 O-LM cells EPSCs also showed significant depression. Over 90 % of the O-LM cells were immunopositive for somatostatin and mGluR1α and all tested cells were decorated by strongly mGluR7a positive axon terminals. Responses in eight of 12 basket cells were described well with a model involving only depression, but the other cells displayed combined facilitating-depressing EPSCs. No apparent difference was found between the plasticity of EPSCs in cholecystokinin- or parvalbumin-containing basket cells. In oriens-bistratified cells (O-Bi), two of nine cells showed facilitating EPSCs, another two depressing, and the remaining five cells combined facilitating-depressing EPSCs. Seven of 10 cells tested for somatostatin were immunopositive, but mGluR1α was detectable only in two of 11 tested cells. Furthermore, most O-Bi cells projected to the CA3 area and the subiculum, as well as outside the hippocampal formation. Postsynaptic responses to action potentials recorded in vivo from a CA1 place cell were modelled, and revealed great differences between and within cell types. Our results demonstrate that the short-term plasticity of EPSCs is cell type dependent, but with significant heterogeneity within all three interneurone populations.","lang":"eng"}],"day":"01","doi":"10.1113/jphysiol.2002.020024","status":"public","extern":1,"main_file_link":[{"url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2290398/","open_access":"1"}],"volume":542,"issue":"1","author":[{"full_name":"Losonczy, Attila","first_name":"Attila","last_name":"Losonczy"},{"first_name":"Limei","last_name":"Zhang","full_name":"Zhang, Limei"},{"last_name":"Shigemoto","first_name":"Ryuichi","full_name":"Ryuichi Shigemoto","orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Somogyi, Péter","last_name":"Somogyi","first_name":"Péter"},{"full_name":"Nusser, Zoltán","first_name":"Zoltán","last_name":"Nusser"}],"publication":"Journal of Physiology","_id":"2617","intvolume":"       542","month":"07","title":"Cell type dependence and variability in the short-term plasticity of EPSCs in identified mouse hippocampal interneurones","date_created":"2018-12-11T11:58:42Z","publication_status":"published","quality_controlled":0,"page":"193 - 210","publisher":"Wiley-Blackwell"},{"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","status":"public","publication_identifier":{"issn":["0021-9967"]},"publist_id":"4279","type":"journal_article","date_published":"2002-09-16T00:00:00Z","language":[{"iso":"eng"}],"oa_version":"None","month":"09","publication":"Journal of Comparative Neurology","volume":451,"extern":"1","day":"16","doi":"10.1002/cne.10344","abstract":[{"lang":"eng","text":"The unipolar brush cell (UBC) is a type of glutamatergic interneuron in the granular layer of the cerebellum. The UBC brush and a single mossy fiber (MF) terminal contact each other within a cerebellar glomerulus, forming a giant synapse. Many UBCs receive input from extrinsic MFs, whereas others are innervated by intrinsic mossy terminals formed by the axons of other UBCs. In all mammalian species so far examined, the vestibulocerebellum is enriched of UBCs that are strongly immunoreactive for the calcium binding protein calretinin (CR) in both the somatodendritic and axonal compartment. UBCs have postsynaptic ionotropic glutamate receptors and extrasynaptic metabotropic glutamate receptors that immunocytochemically highlight their somatodendritic compartment and brush, respectively. In this study on the mouse cerebellum, we present evidence that immunoreactivities to CR and mGluR1α define two distinct UBC subsets with partly overlapping distributions in lobule X (the nodulus). In sections double-labeled for CR and mGluR1α, the patterns of distributions of CR+/mGluR1α- UBCs and CR-/mGluR1α+ UBCs differed along the mediolateral and dorsoventral axes of the folium. Moreover, mGluR1α+ UBCs outnumbered CR+ UBCs. Both UBC subsets were mGluR2/3, GluR2/3, and NMDAR1 immunoreactive. The different distribution patterns of the two UBC subsets within lobule X suggest that expression of CR or mGluR1α by UBCs may be afferent-specific and related to the terminal fields of different vestibular MF afferents."}],"year":"2002","citation":{"ista":"Nunzi M, Shigemoto R, Mugnaini E. 2002. Differential expression of calretinin and metabotropic glutamate receptor mGluR1α defines subsets of unipolar brush cells in mouse cerebellum. Journal of Comparative Neurology. 451(2), 189–199.","short":"M. Nunzi, R. Shigemoto, E. Mugnaini, Journal of Comparative Neurology 451 (2002) 189–199.","mla":"Nunzi, Maria, et al. “Differential Expression of Calretinin and Metabotropic Glutamate Receptor MGluR1α Defines Subsets of Unipolar Brush Cells in Mouse Cerebellum.” <i>Journal of Comparative Neurology</i>, vol. 451, no. 2, Wiley-Blackwell, 2002, pp. 189–99, doi:<a href=\"https://doi.org/10.1002/cne.10344\">10.1002/cne.10344</a>.","chicago":"Nunzi, Maria, Ryuichi Shigemoto, and Enrico Mugnaini. “Differential Expression of Calretinin and Metabotropic Glutamate Receptor MGluR1α Defines Subsets of Unipolar Brush Cells in Mouse Cerebellum.” <i>Journal of Comparative Neurology</i>. Wiley-Blackwell, 2002. <a href=\"https://doi.org/10.1002/cne.10344\">https://doi.org/10.1002/cne.10344</a>.","ieee":"M. Nunzi, R. Shigemoto, and E. Mugnaini, “Differential expression of calretinin and metabotropic glutamate receptor mGluR1α defines subsets of unipolar brush cells in mouse cerebellum,” <i>Journal of Comparative Neurology</i>, vol. 451, no. 2. Wiley-Blackwell, pp. 189–199, 2002.","ama":"Nunzi M, Shigemoto R, Mugnaini E. Differential expression of calretinin and metabotropic glutamate receptor mGluR1α defines subsets of unipolar brush cells in mouse cerebellum. <i>Journal of Comparative Neurology</i>. 2002;451(2):189-199. doi:<a href=\"https://doi.org/10.1002/cne.10344\">10.1002/cne.10344</a>","apa":"Nunzi, M., Shigemoto, R., &#38; Mugnaini, E. (2002). Differential expression of calretinin and metabotropic glutamate receptor mGluR1α defines subsets of unipolar brush cells in mouse cerebellum. <i>Journal of Comparative Neurology</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1002/cne.10344\">https://doi.org/10.1002/cne.10344</a>"},"date_updated":"2023-07-25T09:09:48Z","external_id":{"pmid":["12209836"]},"publisher":"Wiley-Blackwell","article_type":"original","quality_controlled":"1","page":"189 - 199","article_processing_charge":"No","date_created":"2018-12-11T11:58:42Z","publication_status":"published","intvolume":"       451","title":"Differential expression of calretinin and metabotropic glutamate receptor mGluR1α defines subsets of unipolar brush cells in mouse cerebellum","scopus_import":"1","pmid":1,"_id":"2618","issue":"2","author":[{"full_name":"Nunzi, Maria","last_name":"Nunzi","first_name":"Maria"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444","last_name":"Shigemoto","first_name":"Ryuichi"},{"first_name":"Enrico","last_name":"Mugnaini","full_name":"Mugnaini, Enrico"}]},{"volume":12,"acknowledgement":"We thank Dr C. Paspalas for an initial contribution to the immunocytochemistry. We are grateful for the generous gifts of antibodies from Dr A. Buchan (anti-somatostatin, Department of Physiology, University of British Columbia, Canada), Dr M. Watanabe (anti-mGluR1α, Department of Anatomy, Hokkaido University School of Medicine, Sapporo) and Dr K. Tanaka (anti-GAD, Niigata University, Faculty of Medicine, Department of Neurology). We thank Dr F. Ferraguti for helpful suggestions during the project and for his comments on a previous version of the manuscript. We also thank Philip Cobden, Paul Jays and Laszlo Marton for assistance. Y.D. was supported by a Wellcome Trust Advanced Training Fellowship.","extern":"1","day":"01","doi":"10.1093/cercor/12.9.961","abstract":[{"text":"The release of glutamate and GABA is modulated by presynaptic metabotropic glutamate receptors (mGluRs). We used immunocytochemical methods to define the location of the group III receptor mGluR7a in glutamatergic and GABAergic terminals innervating GABAergic interneurons and pyramidal cells. Immunoreactivity for mGluR7a was localized in the presynaptic active zone of both identified GABAergic and presumed glutamatergic terminals. Terminals innervating dendritic spines showed a variable level of receptor immunoreactivity, ranging from immunonegative to strongly immunopositive. The frequency of strongly mGluR7a positive terminals innervating the soma and dendrites of mGluR1α/somatostatin-expressing interneurons was very high relative to other neurons. On dendrites that received mGluR7a-enriched glutamatergic innervation, at least 80% of GABAergic terminals were immunopositive for mGluR7a. On such dendrites virtually all (95%) vasoactive intestinal polypeptide (VIP) positive (GABAergic) terminals were enriched in mGluR7a. The targets of VIP/mGluR7a-expressing terminals were mainly (88%) mGluR1α-expressing interneurons, which were mostly somatostatin immunopositive. Parvalbumin positive terminals were immunonegative for mGluR7a. Some parvalbumin immunoreactive dendrites received strongly mGluR7a positive terminals. The subcellular location, as well as the cell type and synapse-specific distribution of mGluR7a in isocortical neuronal circuits, is homologous to its distribution in the hippocampus. The specific location of mGluR7a in the presynaptic active zone of both glutamatergic and GABAergic synapses may be related to the proximity of calcium channels and the vesicle fusion machinery. The enrichment of mGluR7a in the main GABAergic, as well as in the glutamatergic, innervation of mGluR1α/somatostatin-expressing interneurons suggests that their activation is under unique regulation by extracellular glutamate.","lang":"eng"}],"year":"2002","citation":{"ista":"Dalezios Y, Luján R, Shigemoto R, Roberts J, Somogyi P. 2002. Enrichment of mGluR7a in the Presynaptic active zones of GABAergic and Non-GABAergic terminals on interneurons in the rat somatosensory cortex. Cerebral Cortex. 12(9), 961–974.","short":"Y. Dalezios, R. Luján, R. Shigemoto, J. Roberts, P. Somogyi, Cerebral Cortex 12 (2002) 961–974.","mla":"Dalezios, Yannis, et al. “Enrichment of MGluR7a in the Presynaptic Active Zones of GABAergic and Non-GABAergic Terminals on Interneurons in the Rat Somatosensory Cortex.” <i>Cerebral Cortex</i>, vol. 12, no. 9, Oxford University Press, 2002, pp. 961–74, doi:<a href=\"https://doi.org/10.1093/cercor/12.9.961\">10.1093/cercor/12.9.961</a>.","chicago":"Dalezios, Yannis, Rafael Luján, Ryuichi Shigemoto, John Roberts, and Péter Somogyi. “Enrichment of MGluR7a in the Presynaptic Active Zones of GABAergic and Non-GABAergic Terminals on Interneurons in the Rat Somatosensory Cortex.” <i>Cerebral Cortex</i>. Oxford University Press, 2002. <a href=\"https://doi.org/10.1093/cercor/12.9.961\">https://doi.org/10.1093/cercor/12.9.961</a>.","ieee":"Y. Dalezios, R. Luján, R. Shigemoto, J. Roberts, and P. Somogyi, “Enrichment of mGluR7a in the Presynaptic active zones of GABAergic and Non-GABAergic terminals on interneurons in the rat somatosensory cortex,” <i>Cerebral Cortex</i>, vol. 12, no. 9. Oxford University Press, pp. 961–974, 2002.","ama":"Dalezios Y, Luján R, Shigemoto R, Roberts J, Somogyi P. Enrichment of mGluR7a in the Presynaptic active zones of GABAergic and Non-GABAergic terminals on interneurons in the rat somatosensory cortex. <i>Cerebral Cortex</i>. 2002;12(9):961-974. doi:<a href=\"https://doi.org/10.1093/cercor/12.9.961\">10.1093/cercor/12.9.961</a>","apa":"Dalezios, Y., Luján, R., Shigemoto, R., Roberts, J., &#38; Somogyi, P. (2002). Enrichment of mGluR7a in the Presynaptic active zones of GABAergic and Non-GABAergic terminals on interneurons in the rat somatosensory cortex. <i>Cerebral Cortex</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/cercor/12.9.961\">https://doi.org/10.1093/cercor/12.9.961</a>"},"date_updated":"2023-07-25T09:40:49Z","external_id":{"pmid":["12183395"]},"publisher":"Oxford University Press","article_type":"original","quality_controlled":"1","page":"961 - 974","article_processing_charge":"No","date_created":"2018-12-11T11:58:42Z","publication_status":"published","intvolume":"        12","title":"Enrichment of mGluR7a in the Presynaptic active zones of GABAergic and Non-GABAergic terminals on interneurons in the rat somatosensory cortex","scopus_import":"1","pmid":1,"_id":"2619","issue":"9","author":[{"full_name":"Dalezios, Yannis","last_name":"Dalezios","first_name":"Yannis"},{"last_name":"Luján","first_name":"Rafael","full_name":"Luján, Rafael"},{"last_name":"Shigemoto","first_name":"Ryuichi","full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Roberts","first_name":"John","full_name":"Roberts, John"},{"last_name":"Somogyi","first_name":"Péter","full_name":"Somogyi, Péter"}],"status":"public","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publication_identifier":{"issn":["1047-3211"]},"publist_id":"4280","type":"journal_article","date_published":"2002-09-01T00:00:00Z","language":[{"iso":"eng"}],"oa_version":"None","month":"09","publication":"Cerebral Cortex"},{"publisher":"Nature Publishing Group","article_type":"original","page":"1185 - 1193","quality_controlled":"1","publication_status":"published","article_processing_charge":"No","date_created":"2018-12-11T11:58:43Z","title":"Polarized and compartment-dependent distribution of HCN1 in pyramidal cell dendrites","intvolume":"         5","_id":"2620","pmid":1,"scopus_import":"1","author":[{"full_name":"Lörincz, Andrea","first_name":"Andrea","last_name":"Lörincz"},{"full_name":"Notomi, Takuya","last_name":"Notomi","first_name":"Takuya"},{"full_name":"Tamás, Gábor","last_name":"Tamás","first_name":"Gábor"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi","first_name":"Ryuichi","last_name":"Shigemoto"},{"first_name":"Zoltán","last_name":"Nusser","full_name":"Nusser, Zoltán"}],"issue":"11","volume":5,"acknowledgement":"Z.N. received grants from the Hungarian Science Foundation (T032309), the Howard Hughes Medical Institute, the James S. McDonnell Foundation, the Wellcome Trust and the Boehringer Ingelheim Fund. Z.N. and R.S. received grants from CREST—Japan Science and Technology Corporation. G.T. is funded by the Wellcome Trust.","extern":"1","doi":"10.1038/nn962","day":"01","abstract":[{"lang":"eng","text":"An ion channel's function depends largely on its location and density on neurons. Here we used high-resolution immunolocalization to determine the subcellular distribution of the hyperpolarization-activated and cyclic-nucleotide-gated channel subunit 1 (HCN1) in rat brain. Light microscopy revealed graded HCN1 immunoreactivity in apical dendrites of hippocampal, subicular and neocortical layer-5 pyramidal cells. Quantitative comparison of immunogold densities showed a 60-fold increase from somatic to distal apical dendritic membranes. Distal dendritic shafts had 16 times more HCN1 labeling than proximal dendrites of similar diameters. At the same distance from the soma, the density of HCN1 was significantly higher in dendritic shafts than in spines. Our results reveal the complex cell surface distribution of voltage-gated ion-channels, and predict its role in increasing the computational power of single neurons via subcellular domain and input-specific mechanisms."}],"date_updated":"2023-07-25T09:02:48Z","year":"2002","citation":{"apa":"Lörincz, A., Notomi, T., Tamás, G., Shigemoto, R., &#38; Nusser, Z. (2002). Polarized and compartment-dependent distribution of HCN1 in pyramidal cell dendrites. <i>Nature Neuroscience</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/nn962\">https://doi.org/10.1038/nn962</a>","ama":"Lörincz A, Notomi T, Tamás G, Shigemoto R, Nusser Z. Polarized and compartment-dependent distribution of HCN1 in pyramidal cell dendrites. <i>Nature Neuroscience</i>. 2002;5(11):1185-1193. doi:<a href=\"https://doi.org/10.1038/nn962\">10.1038/nn962</a>","chicago":"Lörincz, Andrea, Takuya Notomi, Gábor Tamás, Ryuichi Shigemoto, and Zoltán Nusser. “Polarized and Compartment-Dependent Distribution of HCN1 in Pyramidal Cell Dendrites.” <i>Nature Neuroscience</i>. Nature Publishing Group, 2002. <a href=\"https://doi.org/10.1038/nn962\">https://doi.org/10.1038/nn962</a>.","ieee":"A. Lörincz, T. Notomi, G. Tamás, R. Shigemoto, and Z. Nusser, “Polarized and compartment-dependent distribution of HCN1 in pyramidal cell dendrites,” <i>Nature Neuroscience</i>, vol. 5, no. 11. Nature Publishing Group, pp. 1185–1193, 2002.","short":"A. Lörincz, T. Notomi, G. Tamás, R. Shigemoto, Z. Nusser, Nature Neuroscience 5 (2002) 1185–1193.","mla":"Lörincz, Andrea, et al. “Polarized and Compartment-Dependent Distribution of HCN1 in Pyramidal Cell Dendrites.” <i>Nature Neuroscience</i>, vol. 5, no. 11, Nature Publishing Group, 2002, pp. 1185–93, doi:<a href=\"https://doi.org/10.1038/nn962\">10.1038/nn962</a>.","ista":"Lörincz A, Notomi T, Tamás G, Shigemoto R, Nusser Z. 2002. Polarized and compartment-dependent distribution of HCN1 in pyramidal cell dendrites. Nature Neuroscience. 5(11), 1185–1193."},"external_id":{"pmid":["12389030"]},"language":[{"iso":"eng"}],"oa_version":"None","month":"11","publication":"Nature Neuroscience","status":"public","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publication_identifier":{"issn":["1097-6256"]},"publist_id":"4278","date_published":"2002-11-01T00:00:00Z","type":"journal_article"},{"issue":"49","author":[{"full_name":"Millán, Carmelo","first_name":"Carmelo","last_name":"Millán"},{"full_name":"Luján, Rafael","last_name":"Luján","first_name":"Rafael"},{"first_name":"Ryuichi","last_name":"Shigemoto","orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Sánchez Prieto","first_name":"José","full_name":"Sánchez Prieto, José"}],"scopus_import":"1","pmid":1,"_id":"2621","intvolume":"       277","title":"Subtype-specific expression of Group III metabotropic glutamate receptors and Ca2+ channels in single nerve terminals","article_processing_charge":"No","date_created":"2018-12-11T11:58:43Z","publication_status":"published","quality_controlled":"1","page":"47796 - 47803","article_type":"original","publisher":"American Society for Biochemistry and Molecular Biology","external_id":{"pmid":["12376542"]},"year":"2002","citation":{"mla":"Millán, Carmelo, et al. “Subtype-Specific Expression of Group III Metabotropic Glutamate Receptors and Ca2+ Channels in Single Nerve Terminals.” <i>Journal of Biological Chemistry</i>, vol. 277, no. 49, American Society for Biochemistry and Molecular Biology, 2002, pp. 47796–803, doi:<a href=\"https://doi.org/10.1074/jbc.M207531200\">10.1074/jbc.M207531200</a>.","short":"C. Millán, R. Luján, R. Shigemoto, J. Sánchez Prieto, Journal of Biological Chemistry 277 (2002) 47796–47803.","ista":"Millán C, Luján R, Shigemoto R, Sánchez Prieto J. 2002. Subtype-specific expression of Group III metabotropic glutamate receptors and Ca2+ channels in single nerve terminals. Journal of Biological Chemistry. 277(49), 47796–47803.","ama":"Millán C, Luján R, Shigemoto R, Sánchez Prieto J. Subtype-specific expression of Group III metabotropic glutamate receptors and Ca2+ channels in single nerve terminals. <i>Journal of Biological Chemistry</i>. 2002;277(49):47796-47803. doi:<a href=\"https://doi.org/10.1074/jbc.M207531200\">10.1074/jbc.M207531200</a>","apa":"Millán, C., Luján, R., Shigemoto, R., &#38; Sánchez Prieto, J. (2002). Subtype-specific expression of Group III metabotropic glutamate receptors and Ca2+ channels in single nerve terminals. <i>Journal of Biological Chemistry</i>. American Society for Biochemistry and Molecular Biology. <a href=\"https://doi.org/10.1074/jbc.M207531200\">https://doi.org/10.1074/jbc.M207531200</a>","chicago":"Millán, Carmelo, Rafael Luján, Ryuichi Shigemoto, and José Sánchez Prieto. “Subtype-Specific Expression of Group III Metabotropic Glutamate Receptors and Ca2+ Channels in Single Nerve Terminals.” <i>Journal of Biological Chemistry</i>. American Society for Biochemistry and Molecular Biology, 2002. <a href=\"https://doi.org/10.1074/jbc.M207531200\">https://doi.org/10.1074/jbc.M207531200</a>.","ieee":"C. Millán, R. Luján, R. Shigemoto, and J. Sánchez Prieto, “Subtype-specific expression of Group III metabotropic glutamate receptors and Ca2+ channels in single nerve terminals,” <i>Journal of Biological Chemistry</i>, vol. 277, no. 49. American Society for Biochemistry and Molecular Biology, pp. 47796–47803, 2002."},"date_updated":"2023-07-19T07:49:19Z","abstract":[{"lang":"eng","text":"The release properties of glutamatergic nerve terminals are influenced by a number of factors, including the subtype of voltage-dependent calcium channel and the presence of presynaptic autoreceptors. Group III metabotropic glutamate receptors (mGluRs) mediate feedback inhibition of glutamate release by inhibiting Ca2+ channel activity. By imaging Ca2+ in preparations of cerebrocortical nerve terminals, we show that voltage-dependent Ca2+ channels are distributed in a heterogeneous manner in individual nerve terminals. Presynaptic terminals contained only N-type (47.5%; conotoxin GVIA-sensitive), P/Q-type (3.9%; agatoxin IVA-sensitive), or both N- and P/Q-type (42.6%) Ca2+ channels, although the remainder of the terminals (6.1%) were insensitive to these two toxins. In this preparation, two mGluRs with high and low affinity for L(+)-2-amino-4-phosphonobutyrate were identified by immunocytochemistry as mGluR4 and mGluR7, respectively. These receptors were responsible for 22.2 and 24.1% reduction of glutamate release, and they reduced the Ca2+ response in 24.4 and 30.3% of the nerve terminals, respectively. Interestingly, mGluR4 was largely (73.7%) located in nerve terminals expressing both N- and P/Q-type Ca2+ channels, whereas mGluR7 was predominantly (69.9%) located in N-type Ca2+ channel-expressing terminals. This specific coexpression of different group III mGluRs and Ca2+ channels may endow synaptic terminals with distinct release properties and reveals the existence of a high degree of presynaptic heterogeneity."}],"day":"02","doi":"10.1074/jbc.M207531200","extern":"1","acknowledgement":"We thank M. Sefton for editorial assistance.","volume":277,"publication":"Journal of Biological Chemistry","month":"12","oa_version":"Published Version","language":[{"iso":"eng"}],"type":"journal_article","date_published":"2002-12-02T00:00:00Z","publist_id":"4277","publication_identifier":{"issn":["0021-9258"]},"status":"public","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17"},{"external_id":{"pmid":["12081656"]},"date_updated":"2023-07-19T07:30:39Z","year":"2002","citation":{"ista":"López Bendito G, Shigemoto R, Kulik Á, Paulsen O, Fairén A, Luján R. 2002. Expression and distribution of metabotropic GABA receptor subtypes GABABR1 and GABABR2 during rat neocortical development. European Journal of Neuroscience. 15(11), 1766–1778.","mla":"López Bendito, Guillermina, et al. “Expression and Distribution of Metabotropic GABA Receptor Subtypes GABABR1 and GABABR2 during Rat Neocortical Development.” <i>European Journal of Neuroscience</i>, vol. 15, no. 11, Wiley-Blackwell, 2002, pp. 1766–78, doi:<a href=\"https://doi.org/10.1046/j.1460-9568.2002.02032.x\">10.1046/j.1460-9568.2002.02032.x</a>.","short":"G. López Bendito, R. Shigemoto, Á. Kulik, O. Paulsen, A. Fairén, R. Luján, European Journal of Neuroscience 15 (2002) 1766–1778.","ieee":"G. López Bendito, R. Shigemoto, Á. Kulik, O. Paulsen, A. Fairén, and R. Luján, “Expression and distribution of metabotropic GABA receptor subtypes GABABR1 and GABABR2 during rat neocortical development,” <i>European Journal of Neuroscience</i>, vol. 15, no. 11. Wiley-Blackwell, pp. 1766–1778, 2002.","chicago":"López Bendito, Guillermina, Ryuichi Shigemoto, Ákos Kulik, Ole Paulsen, Alfonso Fairén, and Rafael Luján. “Expression and Distribution of Metabotropic GABA Receptor Subtypes GABABR1 and GABABR2 during Rat Neocortical Development.” <i>European Journal of Neuroscience</i>. Wiley-Blackwell, 2002. <a href=\"https://doi.org/10.1046/j.1460-9568.2002.02032.x\">https://doi.org/10.1046/j.1460-9568.2002.02032.x</a>.","ama":"López Bendito G, Shigemoto R, Kulik Á, Paulsen O, Fairén A, Luján R. Expression and distribution of metabotropic GABA receptor subtypes GABABR1 and GABABR2 during rat neocortical development. <i>European Journal of Neuroscience</i>. 2002;15(11):1766-1778. doi:<a href=\"https://doi.org/10.1046/j.1460-9568.2002.02032.x\">10.1046/j.1460-9568.2002.02032.x</a>","apa":"López Bendito, G., Shigemoto, R., Kulik, Á., Paulsen, O., Fairén, A., &#38; Luján, R. (2002). Expression and distribution of metabotropic GABA receptor subtypes GABABR1 and GABABR2 during rat neocortical development. <i>European Journal of Neuroscience</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1046/j.1460-9568.2002.02032.x\">https://doi.org/10.1046/j.1460-9568.2002.02032.x</a>"},"abstract":[{"lang":"eng","text":"To understand the possible contribution of metabotropic γ-aminobutyric acid receptors (GABABR) in cortical development, we investigated the expression pattern and the cellular and subcellular localization of the GABABR1 and GABABR2 subtypes in the rat neocortex from embryonic day 14 (E14) to adulthood. At the light microscopic level, both GABABR1 and GABABR2 were detected as early as E14. During prenatal development, both subtypes were expressed highly in the cortical plate. Using double immunofluorescence, GABABR1 colocalized with GABABR2 in neurons of the marginal zone and subplate, indicating that these proteins are coexpressed and could be forming functional GABABRs during prenatal development in vivo. In contrast, only GABABR1 but not GABABR2 was detected in the tangentially migratory cells in the lower intermediate zone. During postnatal development, immunoreactivity for GABABR1 and GABABR2 was distributed mainly in pyramidal cells. Discrete GABABR1-immunopositive cell bodies of interneurons were present throughout the neocortex. In addition, GABABR1 but not GABABR2 was found in identified Cajal-Retzius cells in layer I. At the electron microscopic level, immunoreactivity for GABABR1 and GABABR2 was found in dendritic spines and dendritic shafts at extrasynaptic and perisynaptic sites throughout postnatal development. We further demonstrated the presynaptic localization of GABABR1 and GABABR2, as well as the association of the receptors with asymmetrical synaptic junctions. These results indicate potentially important roles for the GABABRs in the regulation of migratory processes during corticogenesis and in the modulation of synaptic transmission during early development of cortical circuitry."}],"doi":"10.1046/j.1460-9568.2002.02032.x","day":"01","extern":"1","acknowledgement":"The authors are grateful to Dr Marco Sassoe-Pogneto for his comments on a previous version of the manuscript. We also would like to thank to Ms. Courtney Voelker for the English revision and comments of the manuscript. This work was made possible by grants from the European Community (QLG3-CT-1999–00192, R.L) and the Spanish Ministry of Science and Technology (PB97-0582-CO2-01, A.F).","volume":15,"author":[{"last_name":"López Bendito","first_name":"Guillermina","full_name":"López Bendito, Guillermina"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444","last_name":"Shigemoto","first_name":"Ryuichi"},{"full_name":"Kulik, Ákos","first_name":"Ákos","last_name":"Kulik"},{"full_name":"Paulsen, Ole","last_name":"Paulsen","first_name":"Ole"},{"first_name":"Alfonso","last_name":"Fairén","full_name":"Fairén, Alfonso"},{"last_name":"Luján","first_name":"Rafael","full_name":"Luján, Rafael"}],"issue":"11","pmid":1,"_id":"2622","scopus_import":"1","title":"Expression and distribution of metabotropic GABA receptor subtypes GABABR1 and GABABR2 during rat neocortical development","intvolume":"        15","publication_status":"published","date_created":"2018-12-11T11:58:43Z","article_processing_charge":"No","page":"1766 - 1778","quality_controlled":"1","article_type":"original","publisher":"Wiley-Blackwell","date_published":"2002-06-01T00:00:00Z","type":"journal_article","publist_id":"4276","publication_identifier":{"issn":["0953-816X"]},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","status":"public","publication":"European Journal of Neuroscience","month":"06","oa_version":"None","language":[{"iso":"eng"}]},{"status":"public","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publication_identifier":{"issn":["0953-816X"]},"publist_id":"4275","type":"journal_article","date_published":"2002-01-01T00:00:00Z","language":[{"iso":"eng"}],"oa_version":"None","month":"01","publication":"European Journal of Neuroscience","acknowledgement":"This work was supported by research grants from the Ministry of Education, Science, Sports and Culture of Japan, and the Japan Society for the Promotion of Science (P96319). We thank Drs L. Zaborszky and R. Luján for their comments on the manuscript, Dr M. Watanabe for kindly supplying us with GluRδ2 and AMPA GluR1 antibodies, Dr R.E. Edwards for rabbit BNPI antibody, and J. Hatakeyama and S. Doi for technical assistance.","volume":15,"extern":"1","day":"01","doi":"10.1046/j.0953-816x.2001.01855.x","abstract":[{"lang":"eng","text":"Metabotropic γ-aminobutyric acid receptors (GABABRs) are involved in modulation of synaptic transmission and activity of cerebellar and thalamic neurons. We used subtype-specific antibodies in pre- and postembedding immunohistochemistry combined with three-dimensional reconstruction of labelled profiles and quantification of immunoparticles to reveal the subcellular distribution of pre- and postsynaptic GABABR1a/b and GABABR2 in the rat cerebellum and ventrobasal thalamus. GABABR1a/b and R2 were extensively colocalized in most brain regions including the cerebellum and thalamus. In the cerebellum, immunoreactivity for both subtypes was prevalent in the molecular layer. The most intense immunoreactivity was found in Purkinje cell spines with a high density of immunoparticles at extrasynaptic sites peaking at around 240 nm from glutamatergic synapses between spines and parallel fibre varicosities. This is in contrast to dendrites at sites around GABAergic synapses where sparse and random distribution was found for both subtypes. In addition, more than one-tenth of the synaptic membrane specialization of spine-parallel fibre synapses were labelled at pre- or postsynaptic sites. Weak immunolabelling for both subtypes was also seen in parallel fibres but only rarely in GABAergic axons. In the ventrobasal thalamus, immunolabelling for both receptor subtypes was intense over the dendritic field of thalamocortical cells. Electron microscopy demonstrated an extrasynaptic localization of GABABR1a/b and R2 exclusively in postsynaptic elements. Quantitative analysis further revealed the density of GABABR1a/b around GABAergic synapses was higher than glutamatergic synapses on thalamocortical cell dendrites. The distinct localization of GABABRs relative to synaptic sites in the cerebellum and ventrobasal thalamus suggests that GABABRs differentially regulate activity of different neuronal populations."}],"citation":{"ieee":"Á. Kulik <i>et al.</i>, “Distinct localization of GABAB receptors relative to synaptic sites in the rat cerebellum and ventrobasal thalamus,” <i>European Journal of Neuroscience</i>, vol. 15, no. 2. Wiley-Blackwell, pp. 291–307, 2002.","chicago":"Kulik, Ákos, Kazuhiko Nakadate, Gábor Nyíri, Takuya Notomi, Barbara Malitschek, Bernhard Bettler, and Ryuichi Shigemoto. “Distinct Localization of GABAB Receptors Relative to Synaptic Sites in the Rat Cerebellum and Ventrobasal Thalamus.” <i>European Journal of Neuroscience</i>. Wiley-Blackwell, 2002. <a href=\"https://doi.org/10.1046/j.0953-816x.2001.01855.x\">https://doi.org/10.1046/j.0953-816x.2001.01855.x</a>.","apa":"Kulik, Á., Nakadate, K., Nyíri, G., Notomi, T., Malitschek, B., Bettler, B., &#38; Shigemoto, R. (2002). Distinct localization of GABAB receptors relative to synaptic sites in the rat cerebellum and ventrobasal thalamus. <i>European Journal of Neuroscience</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1046/j.0953-816x.2001.01855.x\">https://doi.org/10.1046/j.0953-816x.2001.01855.x</a>","ama":"Kulik Á, Nakadate K, Nyíri G, et al. Distinct localization of GABAB receptors relative to synaptic sites in the rat cerebellum and ventrobasal thalamus. <i>European Journal of Neuroscience</i>. 2002;15(2):291-307. doi:<a href=\"https://doi.org/10.1046/j.0953-816x.2001.01855.x\">10.1046/j.0953-816x.2001.01855.x</a>","ista":"Kulik Á, Nakadate K, Nyíri G, Notomi T, Malitschek B, Bettler B, Shigemoto R. 2002. Distinct localization of GABAB receptors relative to synaptic sites in the rat cerebellum and ventrobasal thalamus. European Journal of Neuroscience. 15(2), 291–307.","mla":"Kulik, Ákos, et al. “Distinct Localization of GABAB Receptors Relative to Synaptic Sites in the Rat Cerebellum and Ventrobasal Thalamus.” <i>European Journal of Neuroscience</i>, vol. 15, no. 2, Wiley-Blackwell, 2002, pp. 291–307, doi:<a href=\"https://doi.org/10.1046/j.0953-816x.2001.01855.x\">10.1046/j.0953-816x.2001.01855.x</a>.","short":"Á. Kulik, K. Nakadate, G. Nyíri, T. Notomi, B. Malitschek, B. Bettler, R. Shigemoto, European Journal of Neuroscience 15 (2002) 291–307."},"year":"2002","date_updated":"2023-07-18T13:08:40Z","external_id":{"pmid":["11849296"]},"publisher":"Wiley-Blackwell","article_type":"original","quality_controlled":"1","page":"291 - 307","article_processing_charge":"No","date_created":"2018-12-11T11:58:44Z","publication_status":"published","intvolume":"        15","title":"Distinct localization of GABAB receptors relative to synaptic sites in the rat cerebellum and ventrobasal thalamus","scopus_import":"1","_id":"2624","pmid":1,"issue":"2","author":[{"full_name":"Kulik, Ákos","last_name":"Kulik","first_name":"Ákos"},{"last_name":"Nakadate","first_name":"Kazuhiko","full_name":"Nakadate, Kazuhiko"},{"first_name":"Gábor","last_name":"Nyíri","full_name":"Nyíri, Gábor"},{"first_name":"Takuya","last_name":"Notomi","full_name":"Notomi, Takuya"},{"first_name":"Barbara","last_name":"Malitschek","full_name":"Malitschek, Barbara"},{"last_name":"Bettler","first_name":"Bernhard","full_name":"Bettler, Bernhard"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","last_name":"Shigemoto","orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi"}]},{"extern":"1","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","status":"public","date_updated":"2023-07-18T10:23:18Z","citation":{"ista":"Erdös L. 2002.Scaling limits of Schrödinger quantum mechanics. In: Dynamics of Dissipation. LNP, , 487–506.","mla":"Erdös, László. “Scaling Limits of Schrödinger Quantum Mechanics.” <i>Dynamics of Dissipation</i>, Springer, 2002, pp. 487–506, doi:<a href=\"https://doi.org/10.1007/3-540-46122-1_19\">10.1007/3-540-46122-1_19</a>.","short":"L. Erdös, in:, Dynamics of Dissipation, Springer, 2002, pp. 487–506.","chicago":"Erdös, László. “Scaling Limits of Schrödinger Quantum Mechanics.” In <i>Dynamics of Dissipation</i>, 487–506. Lecture Notes in Physics. Springer, 2002. <a href=\"https://doi.org/10.1007/3-540-46122-1_19\">https://doi.org/10.1007/3-540-46122-1_19</a>.","ieee":"L. Erdös, “Scaling limits of Schrödinger quantum mechanics,” in <i>Dynamics of Dissipation</i>, Springer, 2002, pp. 487–506.","apa":"Erdös, L. (2002). Scaling limits of Schrödinger quantum mechanics. In <i>Dynamics of Dissipation</i> (pp. 487–506). Springer. <a href=\"https://doi.org/10.1007/3-540-46122-1_19\">https://doi.org/10.1007/3-540-46122-1_19</a>","ama":"Erdös L. Scaling limits of Schrödinger quantum mechanics. In: <i>Dynamics of Dissipation</i>. Lecture Notes in Physics. Springer; 2002:487-506. doi:<a href=\"https://doi.org/10.1007/3-540-46122-1_19\">10.1007/3-540-46122-1_19</a>"},"year":"2002","date_published":"2002-01-01T00:00:00Z","type":"book_chapter","doi":"10.1007/3-540-46122-1_19","publication_identifier":{"isbn":["9783540441113"]},"day":"01","abstract":[{"text":"We outline the status of rigorous derivations of certain classical evolution equations as limits of Schrödinger dynamics. We explain two recent results jointly with H.T. Yau in more details. The first one is the derivation of the linear Boltzmann equation as the long time limit of the one-body Schrödinger equation with a random potential. The second one is the mean field limit of high density bosons with Coulomb interaction that leads to the nonlinear Hartree equation.","lang":"eng"}],"publist_id":"4203","page":"487 - 506","series_title":"Lecture Notes in Physics","quality_controlled":"1","language":[{"iso":"eng"}],"publisher":"Springer","conference":{"name":"38th Winter School of Theoretical Physics : Dynamical Semigroups: Dissipation, Chaos, Quanta"},"_id":"2694","publication":"Dynamics of Dissipation","author":[{"id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5366-9603","full_name":"Erdös, László","first_name":"László","last_name":"Erdös"}],"publication_status":"published","oa_version":"None","article_processing_charge":"No","date_created":"2018-12-11T11:59:06Z","alternative_title":["LNP"],"title":"Scaling limits of Schrödinger quantum mechanics","month":"01"},{"publication_status":"published","date_created":"2018-12-11T11:59:11Z","alternative_title":["Contemporary Mathematics"],"title":"Two dimensional Pauli operator via scalar potential","month":"01","intvolume":"       307","_id":"2708","author":[{"id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","last_name":"Erdös","first_name":"László","full_name":"László Erdös","orcid":"0000-0001-5366-9603"}],"publisher":"World Scientific Publishing","conference":{"name":"QMath: Mathematical Results in Quantum Physics"},"page":"129 - 133","quality_controlled":0,"doi":"10.1090/conm/307","day":"01","publist_id":"4188","date_updated":"2021-01-12T06:59:11Z","citation":{"ista":"Erdös L. 2002. Two dimensional Pauli operator via scalar potential. QMath: Mathematical Results in Quantum Physics, Contemporary Mathematics, vol. 307, 129–133.","short":"L. Erdös, in:, World Scientific Publishing, 2002, pp. 129–133.","mla":"Erdös, László. <i>Two Dimensional Pauli Operator via Scalar Potential</i>. Vol. 307, World Scientific Publishing, 2002, pp. 129–33, doi:<a href=\"https://doi.org/10.1090/conm/307\">10.1090/conm/307</a>.","chicago":"Erdös, László. “Two Dimensional Pauli Operator via Scalar Potential,” 307:129–33. World Scientific Publishing, 2002. <a href=\"https://doi.org/10.1090/conm/307\">https://doi.org/10.1090/conm/307</a>.","ieee":"L. Erdös, “Two dimensional Pauli operator via scalar potential,” presented at the QMath: Mathematical Results in Quantum Physics, 2002, vol. 307, pp. 129–133.","ama":"Erdös L. Two dimensional Pauli operator via scalar potential. In: Vol 307. World Scientific Publishing; 2002:129-133. doi:<a href=\"https://doi.org/10.1090/conm/307\">10.1090/conm/307</a>","apa":"Erdös, L. (2002). Two dimensional Pauli operator via scalar potential (Vol. 307, pp. 129–133). Presented at the QMath: Mathematical Results in Quantum Physics, World Scientific Publishing. <a href=\"https://doi.org/10.1090/conm/307\">https://doi.org/10.1090/conm/307</a>"},"year":"2002","date_published":"2002-01-01T00:00:00Z","type":"conference","volume":307,"extern":1,"status":"public"},{"publication":"Comptes Rendus Mathematique","oa_version":"None","month":"03","language":[{"iso":"eng"}],"date_published":"2002-03-30T00:00:00Z","type":"journal_article","publication_identifier":{"issn":["1631-073X"]},"publist_id":"4155","status":"public","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","_id":"2737","scopus_import":"1","author":[{"first_name":"Claude","last_name":"Bardos","full_name":"Bardos, Claude"},{"first_name":"László","last_name":"Erdös","orcid":"0000-0001-5366-9603","full_name":"Erdös, László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87"},{"first_name":"François","last_name":"Golse","full_name":"Golse, François"},{"full_name":"Mauser, Norbert","last_name":"Mauser","first_name":"Norbert"},{"last_name":"Yau","first_name":"Horng","full_name":"Yau, Horng"}],"issue":"6","publication_status":"published","article_processing_charge":"No","date_created":"2018-12-11T11:59:20Z","title":"Derivation of the Schrödinger-Poisson equation from the quantum N-body problem","intvolume":"       334","page":"515 - 520","quality_controlled":"1","publisher":"Elsevier","article_type":"original","date_updated":"2023-07-18T09:24:24Z","year":"2002","citation":{"ista":"Bardos C, Erdös L, Golse F, Mauser N, Yau H. 2002. Derivation of the Schrödinger-Poisson equation from the quantum N-body problem. Comptes Rendus Mathematique. 334(6), 515–520.","mla":"Bardos, Claude, et al. “Derivation of the Schrödinger-Poisson Equation from the Quantum N-Body Problem.” <i>Comptes Rendus Mathematique</i>, vol. 334, no. 6, Elsevier, 2002, pp. 515–20, doi:<a href=\"https://doi.org/10.1016/S1631-073X(02)02253-7\">10.1016/S1631-073X(02)02253-7</a>.","short":"C. Bardos, L. Erdös, F. Golse, N. Mauser, H. Yau, Comptes Rendus Mathematique 334 (2002) 515–520.","chicago":"Bardos, Claude, László Erdös, François Golse, Norbert Mauser, and Horng Yau. “Derivation of the Schrödinger-Poisson Equation from the Quantum N-Body Problem.” <i>Comptes Rendus Mathematique</i>. Elsevier, 2002. <a href=\"https://doi.org/10.1016/S1631-073X(02)02253-7\">https://doi.org/10.1016/S1631-073X(02)02253-7</a>.","ieee":"C. Bardos, L. Erdös, F. Golse, N. Mauser, and H. Yau, “Derivation of the Schrödinger-Poisson equation from the quantum N-body problem,” <i>Comptes Rendus Mathematique</i>, vol. 334, no. 6. Elsevier, pp. 515–520, 2002.","apa":"Bardos, C., Erdös, L., Golse, F., Mauser, N., &#38; Yau, H. (2002). Derivation of the Schrödinger-Poisson equation from the quantum N-body problem. <i>Comptes Rendus Mathematique</i>. Elsevier. <a href=\"https://doi.org/10.1016/S1631-073X(02)02253-7\">https://doi.org/10.1016/S1631-073X(02)02253-7</a>","ama":"Bardos C, Erdös L, Golse F, Mauser N, Yau H. Derivation of the Schrödinger-Poisson equation from the quantum N-body problem. <i>Comptes Rendus Mathematique</i>. 2002;334(6):515-520. doi:<a href=\"https://doi.org/10.1016/S1631-073X(02)02253-7\">10.1016/S1631-073X(02)02253-7</a>"},"doi":"10.1016/S1631-073X(02)02253-7","day":"30","abstract":[{"text":"We derive the time-dependent Schrödinger–Poisson equation as the weak coupling limit of the N-body linear Schrödinger equation with Coulomb potential.","lang":"eng"}],"acknowledgement":"The authors thank the ESI in Vienna and the Austrian START project “Nonlinear Schrödinger\r\nand quantum Boltzmann equations” of N.J.M. for hospitality and support. Also, F.G. was supported by the Institut\r\nUniversitaire de France and N.J.M. by the bilateral Austrian-French “AMADEUS” programme. H.-T.Y. and L.E. were\r\nsupported by NSF Grants DMS-0072098 and DMS-9970323, respectively","volume":334,"extern":"1"},{"language":[{"iso":"eng"}],"publication":"Journal of Statistical Physics","oa_version":"Submitted Version","month":"06","status":"public","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_published":"2002-06-01T00:00:00Z","type":"journal_article","publication_identifier":{"issn":["0022-4715"]},"publist_id":"4154","page":"1043 - 1127","quality_controlled":"1","publisher":"Springer","article_type":"original","_id":"2738","scopus_import":"1","author":[{"id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","first_name":"László","last_name":"Erdös","orcid":"0000-0001-5366-9603","full_name":"Erdös, László"}],"issue":"5-6","publication_status":"published","date_created":"2018-12-11T11:59:20Z","article_processing_charge":"No","title":"Linear Boltzmann equation as the long time dynamics of an electron weakly coupled to a phonon field","intvolume":"       107","volume":107,"acknowledgement":"This work initially was a joint project with H.-T. Yau and several ideas\r\npresented here have been developed in collaboration with him. I would like\r\nto thank him for the invaluable discussions and encouragement through\r\nthe entire work. Part of this project was completed during several visits at\r\nthe Erwin Schrödinger Institute, Vienna, and at the Center of Theoretical\r\nStudies, Hsinchu, Taiwan. The author is grateful for the hospitality and\r\nfinancial support. This work was partially supported by NSF Grant DMS9970323.","extern":"1","date_updated":"2023-07-18T09:08:45Z","citation":{"ista":"Erdös L. 2002. Linear Boltzmann equation as the long time dynamics of an electron weakly coupled to a phonon field. Journal of Statistical Physics. 107(5–6), 1043–1127.","short":"L. Erdös, Journal of Statistical Physics 107 (2002) 1043–1127.","mla":"Erdös, László. “Linear Boltzmann Equation as the Long Time Dynamics of an Electron Weakly Coupled to a Phonon Field.” <i>Journal of Statistical Physics</i>, vol. 107, no. 5–6, Springer, 2002, pp. 1043–127, doi:<a href=\"https://doi.org/10.1023/A:1015157624384\">10.1023/A:1015157624384</a>.","ieee":"L. Erdös, “Linear Boltzmann equation as the long time dynamics of an electron weakly coupled to a phonon field,” <i>Journal of Statistical Physics</i>, vol. 107, no. 5–6. Springer, pp. 1043–1127, 2002.","chicago":"Erdös, László. “Linear Boltzmann Equation as the Long Time Dynamics of an Electron Weakly Coupled to a Phonon Field.” <i>Journal of Statistical Physics</i>. Springer, 2002. <a href=\"https://doi.org/10.1023/A:1015157624384\">https://doi.org/10.1023/A:1015157624384</a>.","ama":"Erdös L. Linear Boltzmann equation as the long time dynamics of an electron weakly coupled to a phonon field. <i>Journal of Statistical Physics</i>. 2002;107(5-6):1043-1127. doi:<a href=\"https://doi.org/10.1023/A:1015157624384\">10.1023/A:1015157624384</a>","apa":"Erdös, L. (2002). Linear Boltzmann equation as the long time dynamics of an electron weakly coupled to a phonon field. <i>Journal of Statistical Physics</i>. Springer. <a href=\"https://doi.org/10.1023/A:1015157624384\">https://doi.org/10.1023/A:1015157624384</a>"},"year":"2002","external_id":{"arxiv":["math-ph/0108025"]},"arxiv":1,"doi":"10.1023/A:1015157624384","day":"01","abstract":[{"lang":"eng","text":"We consider the long time evolution of a quantum particle weakly interacting with a phonon field. We show that in the weak coupling limit the Wigner distribution of the electron density matrix converges to the solution of the linear Boltzmann equation globally in time. The collision kernel is identified as the sum of an emission and an absorption term that depend on the equilibrium distribution of the free phonon modes."}]},{"article_processing_charge":"No","date_created":"2018-12-11T11:59:21Z","publication_status":"published","intvolume":"       225","title":"Pauli operator and Aharonov–Casher theorem¶ for measure valued magnetic fields","scopus_import":"1","_id":"2739","issue":"2","author":[{"id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","full_name":"Erdös, László","orcid":"0000-0001-5366-9603","last_name":"Erdös","first_name":"László"},{"last_name":"Vougalter","first_name":"Vitali","full_name":"Vougalter, Vitali"}],"publisher":"Springer","article_type":"original","quality_controlled":"1","page":"399 - 421","day":"01","arxiv":1,"doi":"10.1007/s002200100585","abstract":[{"text":"We define the two dimensional Pauli operator and identify its core for magnetic fields that are regular Borel measures. The magnetic field is generated by a scalar potential hence we bypass the usual A L 2loc condition on the vector potential, which does not allow to consider such singular fields. We extend the Aharonov-Casher theorem for magnetic fields that are measures with finite total variation and we present a counterexample in case of infinite total variation. One of the key technical tools is a weighted L 2 estimate on a singular integral operator.","lang":"eng"}],"year":"2002","citation":{"apa":"Erdös, L., &#38; Vougalter, V. (2002). Pauli operator and Aharonov–Casher theorem¶ for measure valued magnetic fields. <i>Communications in Mathematical Physics</i>. Springer. <a href=\"https://doi.org/10.1007/s002200100585\">https://doi.org/10.1007/s002200100585</a>","ama":"Erdös L, Vougalter V. Pauli operator and Aharonov–Casher theorem¶ for measure valued magnetic fields. <i>Communications in Mathematical Physics</i>. 2002;225(2):399-421. doi:<a href=\"https://doi.org/10.1007/s002200100585\">10.1007/s002200100585</a>","chicago":"Erdös, László, and Vitali Vougalter. “Pauli Operator and Aharonov–Casher Theorem¶ for Measure Valued Magnetic Fields.” <i>Communications in Mathematical Physics</i>. Springer, 2002. <a href=\"https://doi.org/10.1007/s002200100585\">https://doi.org/10.1007/s002200100585</a>.","ieee":"L. Erdös and V. Vougalter, “Pauli operator and Aharonov–Casher theorem¶ for measure valued magnetic fields,” <i>Communications in Mathematical Physics</i>, vol. 225, no. 2. Springer, pp. 399–421, 2002.","short":"L. Erdös, V. Vougalter, Communications in Mathematical Physics 225 (2002) 399–421.","mla":"Erdös, László, and Vitali Vougalter. “Pauli Operator and Aharonov–Casher Theorem¶ for Measure Valued Magnetic Fields.” <i>Communications in Mathematical Physics</i>, vol. 225, no. 2, Springer, 2002, pp. 399–421, doi:<a href=\"https://doi.org/10.1007/s002200100585\">10.1007/s002200100585</a>.","ista":"Erdös L, Vougalter V. 2002. Pauli operator and Aharonov–Casher theorem¶ for measure valued magnetic fields. Communications in Mathematical Physics. 225(2), 399–421."},"date_updated":"2023-07-18T08:57:54Z","external_id":{"arxiv":["math-ph/0109015v1"]},"acknowledgement":"This work started during the first author’s visit at the Erwin Schrödinger Institute, Vienna.\r\nValuable discussions with T. Hoffmann-Ostenhof and M. Loss are gratefully acknowledged. The authors thank\r\nthe referee for careful reading and comments","volume":225,"extern":"1","oa_version":"None","month":"02","publication":"Communications in Mathematical Physics","language":[{"iso":"eng"}],"publication_identifier":{"issn":["0010-3616"]},"publist_id":"4153","type":"journal_article","date_published":"2002-02-01T00:00:00Z","status":"public","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17"},{"publist_id":"4152","publication_identifier":{"issn":["0373-0956"]},"date_published":"2002-01-01T00:00:00Z","type":"journal_article","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","status":"public","month":"01","oa_version":"None","publication":"Annales de l'Institut Fourier","language":[{"iso":"eng"}],"abstract":[{"text":"We show that the lowest eigenvalue of the magnetic Schrödinger operator on a line bundle over a compact Riemann surface M is bounded by the L1-norm of the magnetic field B. This implies a similar bound on the multiplicity of the ground state. An example shows that this degeneracy can indeed be comparable with ∫M |B| even in case of the trivial bundle.","lang":"eng"}],"doi":"10.5802/aif.1936","day":"01","date_updated":"2023-07-18T08:38:34Z","year":"2002","citation":{"ista":"Erdös L. 2002. Spectral shift and multiplicity of the first eigenvalue of the magnetic Schrödinger operator in two dimensions. Annales de l’Institut Fourier. 52(6), 1833–1874.","short":"L. Erdös, Annales de l’Institut Fourier 52 (2002) 1833–1874.","mla":"Erdös, László. “Spectral Shift and Multiplicity of the First Eigenvalue of the Magnetic Schrödinger Operator in Two Dimensions.” <i>Annales de l’Institut Fourier</i>, vol. 52, no. 6, Association des Annales de l’Institut Fourier, 2002, pp. 1833–74, doi:<a href=\"https://doi.org/10.5802/aif.1936\">10.5802/aif.1936</a>.","ieee":"L. Erdös, “Spectral shift and multiplicity of the first eigenvalue of the magnetic Schrödinger operator in two dimensions,” <i>Annales de l’Institut Fourier</i>, vol. 52, no. 6. Association des Annales de l’Institut Fourier, pp. 1833–1874, 2002.","chicago":"Erdös, László. “Spectral Shift and Multiplicity of the First Eigenvalue of the Magnetic Schrödinger Operator in Two Dimensions.” <i>Annales de l’Institut Fourier</i>. Association des Annales de l’Institut Fourier, 2002. <a href=\"https://doi.org/10.5802/aif.1936\">https://doi.org/10.5802/aif.1936</a>.","apa":"Erdös, L. (2002). Spectral shift and multiplicity of the first eigenvalue of the magnetic Schrödinger operator in two dimensions. <i>Annales de l’Institut Fourier</i>. Association des Annales de l’Institut Fourier. <a href=\"https://doi.org/10.5802/aif.1936\">https://doi.org/10.5802/aif.1936</a>","ama":"Erdös L. Spectral shift and multiplicity of the first eigenvalue of the magnetic Schrödinger operator in two dimensions. <i>Annales de l’Institut Fourier</i>. 2002;52(6):1833-1874. doi:<a href=\"https://doi.org/10.5802/aif.1936\">10.5802/aif.1936</a>"},"extern":"1","volume":52,"title":"Spectral shift and multiplicity of the first eigenvalue of the magnetic Schrödinger operator in two dimensions","intvolume":"        52","publication_status":"published","date_created":"2018-12-11T11:59:21Z","article_processing_charge":"No","author":[{"id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","full_name":"Erdös, László","orcid":"0000-0001-5366-9603","last_name":"Erdös","first_name":"László"}],"issue":"6","_id":"2740","scopus_import":"1","article_type":"original","publisher":"Association des Annales de l'Institut Fourier","page":"1833-1874","quality_controlled":"1"},{"oa_version":"Published Version","month":"07","publication":"Genes and Development","language":[{"iso":"eng"}],"publication_identifier":{"issn":["0890-9369"]},"publist_id":"3921","oa":1,"type":"journal_article","date_published":"2002-07-01T00:00:00Z","main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC186366/"}],"status":"public","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_created":"2018-12-11T12:00:01Z","article_processing_charge":"No","publication_status":"published","intvolume":"        16","title":"The Arabidopsis BODENLOS gene encodes an auxin response protein inhibiting MONOPTEROS-mediated embryo patterning","scopus_import":"1","pmid":1,"_id":"2866","issue":"13","author":[{"last_name":"Hamann","first_name":"Thorsten","full_name":"Hamann, Thorsten"},{"full_name":"Benková, Eva","orcid":"0000-0002-8510-9739","last_name":"Benková","first_name":"Eva","id":"38F4F166-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Bäurle, Isabel","first_name":"Isabel","last_name":"Bäurle"},{"last_name":"Kientz","first_name":"Marika","full_name":"Kientz, Marika"},{"full_name":"Jürgens, Gerd","first_name":"Gerd","last_name":"Jürgens"}],"publisher":"Cold Spring Harbor Laboratory Press","article_type":"original","quality_controlled":"1","page":"1610 - 1615","day":"01","doi":"10.1101/gad.229402","abstract":[{"text":"Developmental responses to the plant hormone auxin are thought to be mediated by interacting pairs from two protein families: short-lived inhibitory IAA proteins and ARF transcription factors binding to auxin-response elements. Monopteros mutants lacking activating ARF5 and the auxin-insensitive mutant bodenlos fail to initiate the root meristem during early embryogenesis. Here we show that the bodenlos phenotype results from an amino-acid exchange in the conserved degradation domain of IAA12. BODENLOS and MONOPTEROS interact in the yeast two-hybrid assay and the two genes are coexpressed in early embryogenesis, suggesting that BODENLOS inhibits MONOPTEROS action in root meristem initiation.","lang":"eng"}],"citation":{"ista":"Hamann T, Benková E, Bäurle I, Kientz M, Jürgens G. 2002. The Arabidopsis BODENLOS gene encodes an auxin response protein inhibiting MONOPTEROS-mediated embryo patterning. Genes and Development. 16(13), 1610–1615.","mla":"Hamann, Thorsten, et al. “The Arabidopsis BODENLOS Gene Encodes an Auxin Response Protein Inhibiting MONOPTEROS-Mediated Embryo Patterning.” <i>Genes and Development</i>, vol. 16, no. 13, Cold Spring Harbor Laboratory Press, 2002, pp. 1610–15, doi:<a href=\"https://doi.org/10.1101/gad.229402\">10.1101/gad.229402</a>.","short":"T. Hamann, E. Benková, I. Bäurle, M. Kientz, G. Jürgens, Genes and Development 16 (2002) 1610–1615.","ieee":"T. Hamann, E. Benková, I. Bäurle, M. Kientz, and G. Jürgens, “The Arabidopsis BODENLOS gene encodes an auxin response protein inhibiting MONOPTEROS-mediated embryo patterning,” <i>Genes and Development</i>, vol. 16, no. 13. Cold Spring Harbor Laboratory Press, pp. 1610–1615, 2002.","chicago":"Hamann, Thorsten, Eva Benková, Isabel Bäurle, Marika Kientz, and Gerd Jürgens. “The Arabidopsis BODENLOS Gene Encodes an Auxin Response Protein Inhibiting MONOPTEROS-Mediated Embryo Patterning.” <i>Genes and Development</i>. Cold Spring Harbor Laboratory Press, 2002. <a href=\"https://doi.org/10.1101/gad.229402\">https://doi.org/10.1101/gad.229402</a>.","apa":"Hamann, T., Benková, E., Bäurle, I., Kientz, M., &#38; Jürgens, G. (2002). The Arabidopsis BODENLOS gene encodes an auxin response protein inhibiting MONOPTEROS-mediated embryo patterning. <i>Genes and Development</i>. Cold Spring Harbor Laboratory Press. <a href=\"https://doi.org/10.1101/gad.229402\">https://doi.org/10.1101/gad.229402</a>","ama":"Hamann T, Benková E, Bäurle I, Kientz M, Jürgens G. The Arabidopsis BODENLOS gene encodes an auxin response protein inhibiting MONOPTEROS-mediated embryo patterning. <i>Genes and Development</i>. 2002;16(13):1610-1615. doi:<a href=\"https://doi.org/10.1101/gad.229402\">10.1101/gad.229402</a>"},"year":"2002","date_updated":"2023-07-18T08:26:58Z","external_id":{"pmid":["12101120"]},"acknowledgement":"We thank C. Maulbetsch for isolating BDL cDNA clones; T. Berleth and J. Friml for providing clones for in situ probes; K. Harter for making available the parsley protoplast system; and J. Friml, N. Geldner, M. Griffith, C. Schwechheimer, D. Weigel, and D. Weijers for helpful comments and critical reading of the manuscript. This work was supported by Sonderforschungsbereich 446 “Mechanismen des Zellverhaltens bei Eukaryoten.”\r\n\r\nThe publication costs of this article were defrayed in part by payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 USC section 1734 solely to indicate this fact.","volume":16,"extern":"1"},{"acknowledgement":"We thank Olga Veksler and Yuri Boykov for their careful reading of this paper, and for valuable comments which greatly improved itsreadibility. We also thank Ian Jermyn for helping us clarify the paper’s motivation. This research was supported by NSF grants IIS-9900115 and CCR-0113371, and by a grant from Microsoft Research.","extern":"1","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","status":"public","date_updated":"2023-07-18T08:20:02Z","year":"2002","citation":{"short":"V. Kolmogorov, R. Zabih, in:, Proceedings of the 7th European Conference on Computer Vision, Springer, 2002, pp. 65–81.","mla":"Kolmogorov, Vladimir, and Ramin Zabih. “Multi-Camera Scene Reconstruction via Graph Cuts.” <i>Proceedings of the 7th European Conference on Computer Vision</i>, Springer, 2002, pp. 65–81, doi:<a href=\"https://doi.org/10.1007/3-540-47977-5_5\">10.1007/3-540-47977-5_5</a>.","ista":"Kolmogorov V, Zabih R. 2002. Multi-camera scene reconstruction via graph cuts. Proceedings of the 7th European Conference on Computer Vision. ECCV: European Conference on Computer Vision, 65–81.","ama":"Kolmogorov V, Zabih R. Multi-camera scene reconstruction via graph cuts. In: <i>Proceedings of the 7th European Conference on Computer Vision</i>. Springer; 2002:65-81. doi:<a href=\"https://doi.org/10.1007/3-540-47977-5_5\">10.1007/3-540-47977-5_5</a>","apa":"Kolmogorov, V., &#38; Zabih, R. (2002). Multi-camera scene reconstruction via graph cuts. In <i>Proceedings of the 7th European Conference on Computer Vision</i> (pp. 65–81). Copenhagen, Denmark: Springer. <a href=\"https://doi.org/10.1007/3-540-47977-5_5\">https://doi.org/10.1007/3-540-47977-5_5</a>","chicago":"Kolmogorov, Vladimir, and Ramin Zabih. “Multi-Camera Scene Reconstruction via Graph Cuts.” In <i>Proceedings of the 7th European Conference on Computer Vision</i>, 65–81. Springer, 2002. <a href=\"https://doi.org/10.1007/3-540-47977-5_5\">https://doi.org/10.1007/3-540-47977-5_5</a>.","ieee":"V. Kolmogorov and R. Zabih, “Multi-camera scene reconstruction via graph cuts,” in <i>Proceedings of the 7th European Conference on Computer Vision</i>, Copenhagen, Denmark, 2002, pp. 65–81."},"date_published":"2002-01-01T00:00:00Z","type":"conference","doi":"10.1007/3-540-47977-5_5","day":"01","publication_identifier":{"isbn":["9783540437468"]},"abstract":[{"lang":"eng","text":"In the last few years, several new algorithms based on graph cuts have been developed to solve energy minimization problems in computer vision. Each of these techniques constructs a graph such that the minimum cut on the graph also minimizes the energy. Yet because these graph constructions are complex and highly specific to a particular energy function, graph cuts have seen limited application to date. In this paper we characterize the energy functions that can be minimized by graph cuts. Our results are restricted to energy functions with binary variables. However, our work generalizes many previous constructions, and is easily applicable to vision problems that involve large numbers of labels, such as stereo, motion, image restoration and scene reconstruction. We present three main results: a necessary condition for any energy function that can be minimized by graph cuts; a sufficient condition for energy functions that can be written as a sum of functions of up to three variables at a time; and a general-purpose construction to minimize such an energy function. Researchers who are considering the use of graph cuts to optimize a particular energy function can use our results to determine if this is possible, and then follow our construction to create the appropriate graph."}],"publist_id":"3810","page":"65 - 81","quality_controlled":"1","language":[{"iso":"eng"}],"publisher":"Springer","conference":{"start_date":"2002-05-28","name":"ECCV: European Conference on Computer Vision","location":"Copenhagen, Denmark","end_date":"2002-05-31"},"publication":"Proceedings of the 7th European Conference on Computer Vision","_id":"2927","scopus_import":"1","author":[{"first_name":"Vladimir","last_name":"Kolmogorov","full_name":"Kolmogorov, Vladimir","id":"3D50B0BA-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Zabih, Ramin","first_name":"Ramin","last_name":"Zabih"}],"publication_status":"published","oa_version":"None","article_processing_charge":"No","date_created":"2018-12-11T12:00:23Z","title":"Multi-camera scene reconstruction via graph cuts","month":"01"},{"external_id":{"pmid":["11845211 "]},"citation":{"short":"J. Friml, J. Wiśniewska, E. Benková, K. Mendgen, K. Palme, Nature 415 (2002) 806–809.","mla":"Friml, Jiří, et al. “Lateral Relocation of Auxin Efflux Regulator PIN3 Mediates Tropism in Arabidopsis.” <i>Nature</i>, vol. 415, no. 6873, Nature Publishing Group, 2002, pp. 806–09, doi:<a href=\"https://doi.org/10.1038/415806a\">10.1038/415806a</a>.","ista":"Friml J, Wiśniewska J, Benková E, Mendgen K, Palme K. 2002. Lateral relocation of auxin efflux regulator PIN3 mediates tropism in Arabidopsis. Nature. 415(6873), 806–809.","ama":"Friml J, Wiśniewska J, Benková E, Mendgen K, Palme K. Lateral relocation of auxin efflux regulator PIN3 mediates tropism in Arabidopsis. <i>Nature</i>. 2002;415(6873):806-809. doi:<a href=\"https://doi.org/10.1038/415806a\">10.1038/415806a</a>","apa":"Friml, J., Wiśniewska, J., Benková, E., Mendgen, K., &#38; Palme, K. (2002). Lateral relocation of auxin efflux regulator PIN3 mediates tropism in Arabidopsis. <i>Nature</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/415806a\">https://doi.org/10.1038/415806a</a>","ieee":"J. Friml, J. Wiśniewska, E. Benková, K. Mendgen, and K. Palme, “Lateral relocation of auxin efflux regulator PIN3 mediates tropism in Arabidopsis,” <i>Nature</i>, vol. 415, no. 6873. Nature Publishing Group, pp. 806–809, 2002.","chicago":"Friml, Jiří, Justyna Wiśniewska, Eva Benková, Kurt Mendgen, and Klaus Palme. “Lateral Relocation of Auxin Efflux Regulator PIN3 Mediates Tropism in Arabidopsis.” <i>Nature</i>. Nature Publishing Group, 2002. <a href=\"https://doi.org/10.1038/415806a\">https://doi.org/10.1038/415806a</a>."},"year":"2002","date_updated":"2023-07-18T07:30:27Z","abstract":[{"lang":"eng","text":"Long-standing models propose that plant growth responses to light or gravity are mediated by asymmetric distribution of the phytohormone auxin. Physiological studies implicated a specific transport system that relocates auxin laterally, thereby effecting differential growth; however, neither the molecular components of this system nor the cellular mechanism of auxin redistribution on light or gravity perception have been identified. Here, we show that auxin accumulates asymmetrically during differential growth in an efflux-dependent manner. Mutations in the Arabidopsis gene PIN3, a regulator of auxin efflux, alter differential growth. PIN3 is expressed in gravity-sensing tissues, with PIN3 protein accumulating predominantly at the lateral cell surface. PIN3 localizes to the plasma membrane and to vesicles that cycle in an actin-dependent manner. In the root columella, PIN3 is positioned symmetrically at the plasma membrane but rapidly relocalizes laterally on gravity stimulation. Our data indicate that PIN3 is a component of the lateral auxin transport system regulating tropic growth. In addition, actin-dependent relocalization of PIN3 in response to gravity provides a mechanism for redirecting auxin flux to trigger asymmetric growth."}],"day":"14","doi":"10.1038/415806a","extern":"1","acknowledgement":"We thank G. Jürgens for enabling J.F. to accomplish part of this work in his laboratory; P. Tänzler and M. Sauer for technical assistance; H. Vahlenkamp for technical assistance in immunocytochemistry; M. Estelle for providing material and suggestions; T. Altman for BAC filter sets; the ADIS (Automated DNA Isolation and Sequencing) service group for DNA sequencing; ZIGIA (Center for Functional Genomics in Arabidopsis) for the En lines; and N. Geldner, T. Hamann, G. Jürgens, K. Schrick and C. Schwechheimer for comments and critical reading of the manuscript. This work was supported by a fellowship of the DAAD (J.F.), the DFG (Schwerpunktprogramm Phytohormone), the Fonds der chemischen Industrie, the European Communities Biotechnology Programs, the INCO-Copernicus Program and the European Space Agency MAP-Biotechnology Programme","volume":415,"issue":"6873","author":[{"full_name":"Friml, Jirí","orcid":"0000-0002-8302-7596","last_name":"Friml","first_name":"Jirí","id":"4159519E-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Wiśniewska, Justyna","last_name":"Wiśniewska","first_name":"Justyna"},{"full_name":"Benková, Eva","orcid":"0000-0002-8510-9739","last_name":"Benková","first_name":"Eva","id":"38F4F166-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Mendgen, Kurt","first_name":"Kurt","last_name":"Mendgen"},{"last_name":"Palme","first_name":"Klaus","full_name":"Palme, Klaus"}],"scopus_import":"1","_id":"2986","pmid":1,"intvolume":"       415","title":"Lateral relocation of auxin efflux regulator PIN3 mediates tropism in Arabidopsis","date_created":"2018-12-11T12:00:42Z","article_processing_charge":"No","publication_status":"published","quality_controlled":"1","page":"806 - 809","article_type":"original","publisher":"Nature Publishing Group","type":"journal_article","date_published":"2002-02-14T00:00:00Z","publist_id":"3715","publication_identifier":{"issn":["0028-0836"]},"status":"public","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publication":"Nature","month":"02","oa_version":"None","language":[{"iso":"eng"}]}]