[{"day":"01","oa_version":"None","publication_status":"published","page":"1017 - 1031","abstract":[{"lang":"eng","text":"The hydra mutants of Arabidopsis are characterized by a pleiotropic phenotype that shows defective embryonic and seedling cell patterning, morphogenesis, and root growth. We demonstrate that the HYDRA1 gene encodes a Δ8-Δ7 sterol isomerase, whereas HYDRA2 encodes a sterol C14 reductase, previously identified as the FACKEL gene product. Seedlings mutant for each gene are similarly defective in the concentrations of the three major Arabidopsis sterols. Promoter::reporter gene analysis showed misexpression of the auxin-regulated DR5 and ACS1 promoters and of the epidermal cell file-specific GL2 promoter in the mutants. The mutants exhibit enhanced responses to auxin. The phenotypes can be rescued partially by inhibition of auxin and ethylene signaling but not by exogenous sterols or brassinosteroids. We propose a model in which correct sterol profiles are required for regulated auxin and ethylene signaling through effects on membrane function."}],"status":"public","date_updated":"2023-07-18T07:34:32Z","publication":"Plant Cell","title":"Hydra mutants of Arabidopsis are defective in sterol profiles and auxin and ethylene signaling","external_id":{"pmid":["12034894"]},"main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC150604/"}],"scopus_import":"1","issue":"5","citation":{"ieee":"M. Souter <i>et al.</i>, “Hydra mutants of Arabidopsis are defective in sterol profiles and auxin and ethylene signaling,” <i>Plant Cell</i>, vol. 14, no. 5. American Society of Plant Biologists, pp. 1017–1031, 2002.","chicago":"Souter, Martin, Jennifer Topping, Margaret Pullen, Jiří Friml, Klaus Palme, Rachel Hackett, Don Grierson, and Keith Lindsey. “Hydra Mutants of Arabidopsis Are Defective in Sterol Profiles and Auxin and Ethylene Signaling.” <i>Plant Cell</i>. American Society of Plant Biologists, 2002. <a href=\"https://doi.org/10.1105/tpc.001248\">https://doi.org/10.1105/tpc.001248</a>.","ama":"Souter M, Topping J, Pullen M, et al. Hydra mutants of Arabidopsis are defective in sterol profiles and auxin and ethylene signaling. <i>Plant Cell</i>. 2002;14(5):1017-1031. doi:<a href=\"https://doi.org/10.1105/tpc.001248\">10.1105/tpc.001248</a>","short":"M. Souter, J. Topping, M. Pullen, J. Friml, K. Palme, R. Hackett, D. Grierson, K. Lindsey, Plant Cell 14 (2002) 1017–1031.","apa":"Souter, M., Topping, J., Pullen, M., Friml, J., Palme, K., Hackett, R., … Lindsey, K. (2002). Hydra mutants of Arabidopsis are defective in sterol profiles and auxin and ethylene signaling. <i>Plant Cell</i>. American Society of Plant Biologists. <a href=\"https://doi.org/10.1105/tpc.001248\">https://doi.org/10.1105/tpc.001248</a>","ista":"Souter M, Topping J, Pullen M, Friml J, Palme K, Hackett R, Grierson D, Lindsey K. 2002. Hydra mutants of Arabidopsis are defective in sterol profiles and auxin and ethylene signaling. Plant Cell. 14(5), 1017–1031.","mla":"Souter, Martin, et al. “Hydra Mutants of Arabidopsis Are Defective in Sterol Profiles and Auxin and Ethylene Signaling.” <i>Plant Cell</i>, vol. 14, no. 5, American Society of Plant Biologists, 2002, pp. 1017–31, doi:<a href=\"https://doi.org/10.1105/tpc.001248\">10.1105/tpc.001248</a>."},"date_published":"2002-05-01T00:00:00Z","author":[{"first_name":"Martin","full_name":"Souter, Martin","last_name":"Souter"},{"last_name":"Topping","first_name":"Jennifer","full_name":"Topping, Jennifer"},{"last_name":"Pullen","first_name":"Margaret","full_name":"Pullen, Margaret"},{"full_name":"Friml, Jirí","first_name":"Jirí","orcid":"0000-0002-8302-7596","id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml"},{"first_name":"Klaus","full_name":"Palme, Klaus","last_name":"Palme"},{"last_name":"Hackett","first_name":"Rachel","full_name":"Hackett, Rachel"},{"last_name":"Grierson","first_name":"Don","full_name":"Grierson, Don"},{"last_name":"Lindsey","full_name":"Lindsey, Keith","first_name":"Keith"}],"_id":"2987","oa":1,"type":"journal_article","doi":"10.1105/tpc.001248","language":[{"iso":"eng"}],"year":"2002","publisher":"American Society of Plant Biologists","article_type":"original","volume":14,"month":"05","publication_identifier":{"issn":["1040-4651"]},"publist_id":"3716","quality_controlled":"1","extern":"1","article_processing_charge":"No","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","intvolume":"        14","date_created":"2018-12-11T12:00:42Z","acknowledgement":"We thank Dr. Ken Feldmann for providing prospective hyd alleles, Dr. Jane Murfett for providing DR5::GUS seed, Dr. D. Van Der Straeten for providing ACS1::GUS seed, Dr. John Schiefelbein for providing GL2::GFP seed, and Dr. Ottoline Leyser for axr1-12 and axr3-1 seed. etr1 and fk seed was obtained from the Nottingham Arabidopsis Stock Centre. This work was supported by a Biotechnology and Biological Science Research Council research studentship to M.S., a Durham University studentship to M.P., and Biotechnology and Biological Science Research Council Grant 12/P02330 to J.T.","pmid":1},{"scopus_import":"1","issue":"4","citation":{"chicago":"Grebe, Markus, Jiří Friml, Ranjan Swarup, Karin Ljung, Göran Sandberg, Maarten Terlou, Klaus Palme, Malcolm Bennett, and Ben Scheres. “Cell Polarity Signaling in Arabidopsis Involves a BFA Sensitive Auxin Influx Pathway.” <i>Current Biology</i>. Cell Press, 2002. <a href=\"https://doi.org/10.1016/S0960-9822(02)00654-1\">https://doi.org/10.1016/S0960-9822(02)00654-1</a>.","ieee":"M. Grebe <i>et al.</i>, “Cell polarity signaling in Arabidopsis involves a BFA sensitive auxin influx pathway,” <i>Current Biology</i>, vol. 12, no. 4. Cell Press, pp. 329–334, 2002.","short":"M. Grebe, J. Friml, R. Swarup, K. Ljung, G. Sandberg, M. Terlou, K. Palme, M. Bennett, B. Scheres, Current Biology 12 (2002) 329–334.","ista":"Grebe M, Friml J, Swarup R, Ljung K, Sandberg G, Terlou M, Palme K, Bennett M, Scheres B. 2002. Cell polarity signaling in Arabidopsis involves a BFA sensitive auxin influx pathway. Current Biology. 12(4), 329–334.","mla":"Grebe, Markus, et al. “Cell Polarity Signaling in Arabidopsis Involves a BFA Sensitive Auxin Influx Pathway.” <i>Current Biology</i>, vol. 12, no. 4, Cell Press, 2002, pp. 329–34, doi:<a href=\"https://doi.org/10.1016/S0960-9822(02)00654-1\">10.1016/S0960-9822(02)00654-1</a>.","apa":"Grebe, M., Friml, J., Swarup, R., Ljung, K., Sandberg, G., Terlou, M., … Scheres, B. (2002). Cell polarity signaling in Arabidopsis involves a BFA sensitive auxin influx pathway. <i>Current Biology</i>. Cell Press. <a href=\"https://doi.org/10.1016/S0960-9822(02)00654-1\">https://doi.org/10.1016/S0960-9822(02)00654-1</a>","ama":"Grebe M, Friml J, Swarup R, et al. Cell polarity signaling in Arabidopsis involves a BFA sensitive auxin influx pathway. <i>Current Biology</i>. 2002;12(4):329-334. doi:<a href=\"https://doi.org/10.1016/S0960-9822(02)00654-1\">10.1016/S0960-9822(02)00654-1</a>"},"title":"Cell polarity signaling in Arabidopsis involves a BFA sensitive auxin influx pathway","external_id":{"pmid":["11864575"]},"publication":"Current Biology","status":"public","date_updated":"2023-07-17T12:15:28Z","abstract":[{"text":"Coordination of cell and tissue polarity commonly involves directional signaling [1]. In the Arabidopsis root epidermis, cell polarity is revealed by basal, root tip-oriented, hair outgrowth from hair-forming cells (trichoblasts) [2]. The plant hormone auxin displays polar movements [1, 3] and accumulates at maximum concentration in the root tip [4, 5]. The application of polar auxin transport inhibitors [3] evokes changes in trichoblast polarity only at high concentrations and after long-term application [2, 4]. Thus, it remains open whether components of the auxin transport machinery mediate establishment of trichoblast polarity. Here we report that the presumptive auxin influx carrier AUX1 [6, 7] contributes to apical-basal hair cell polarity. AUX1 function is required for polarity changes induced by exogenous application of the auxin 2,4-D, a preferential influx carrier substrate. Similar to aux1 mutants, the vesicle trafficking inhibitor brefeldin A (BFA) interferes with polar hair initiation, and AUX1 function is required for BFA-mediated polarity changes. Consistently, BFA inhibits membrane trafficking of AUX1, trichoblast hyperpolarization induced by 2,4-D, and alters the distal auxin maximum. Our results identify AUX1 as one component of a novel BFA-sensitive auxin transport pathway polarizing cells toward a hormone maximum.","lang":"eng"}],"day":"19","publication_status":"published","page":"329 - 334","oa_version":"None","intvolume":"        12","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","extern":"1","article_processing_charge":"No","pmid":1,"date_created":"2018-12-11T12:00:43Z","article_type":"original","volume":12,"publication_identifier":{"issn":["0960-9822"]},"publist_id":"3714","quality_controlled":"1","month":"02","type":"journal_article","year":"2002","publisher":"Cell Press","doi":"10.1016/S0960-9822(02)00654-1","language":[{"iso":"eng"}],"date_published":"2002-02-19T00:00:00Z","_id":"2988","author":[{"first_name":"Markus","full_name":"Grebe, Markus","last_name":"Grebe"},{"full_name":"Friml, Jirí","first_name":"Jirí","last_name":"Friml","id":"4159519E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8302-7596"},{"last_name":"Swarup","first_name":"Ranjan","full_name":"Swarup, Ranjan"},{"first_name":"Karin","full_name":"Ljung, Karin","last_name":"Ljung"},{"last_name":"Sandberg","full_name":"Sandberg, Göran","first_name":"Göran"},{"last_name":"Terlou","first_name":"Maarten","full_name":"Terlou, Maarten"},{"first_name":"Klaus","full_name":"Palme, Klaus","last_name":"Palme"},{"last_name":"Bennett","first_name":"Malcolm","full_name":"Bennett, Malcolm"},{"full_name":"Scheres, Ben","first_name":"Ben","last_name":"Scheres"}]},{"author":[{"first_name":"Jirí","full_name":"Friml, Jirí","last_name":"Friml","id":"4159519E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8302-7596"},{"orcid":"0000-0002-8510-9739","last_name":"Benková","id":"38F4F166-F248-11E8-B48F-1D18A9856A87","first_name":"Eva","full_name":"Benková, Eva"},{"full_name":"Blilou, Ikram","first_name":"Ikram","last_name":"Blilou"},{"last_name":"Wiśniewska","first_name":"Justyna","full_name":"Wiśniewska, Justyna"},{"last_name":"Hamann","first_name":"Thorsten","full_name":"Hamann, Thorsten"},{"last_name":"Ljung","full_name":"Ljung, Karin","first_name":"Karin"},{"last_name":"Woody","full_name":"Woody, Scott","first_name":"Scott"},{"last_name":"Sandberg","full_name":"Sandberg, Göran","first_name":"Göran"},{"first_name":"Ben","full_name":"Scheres, Ben","last_name":"Scheres"},{"first_name":"Gerd","full_name":"Jürgens, Gerd","last_name":"Jürgens"},{"last_name":"Palme","full_name":"Palme, Klaus","first_name":"Klaus"}],"_id":"2989","date_published":"2002-03-08T00:00:00Z","doi":"10.1016/S0092-8674(02)00656-6","language":[{"iso":"eng"}],"year":"2002","publisher":"Cell Press","type":"journal_article","month":"03","publist_id":"3713","publication_identifier":{"issn":["0092-8674"]},"quality_controlled":"1","article_type":"original","volume":108,"date_created":"2018-12-11T12:00:43Z","acknowledgement":"We thank Petra Tänzler, Michaela Lehnen, and Thomas Steinmann for technical help. We acknowledge the Arabidopsis Biological Resource Center (Columbus, OH) and Thomas Altman for providing material. We also gratefully acknowledge the ADIS service group for DNA sequencing and ZIGIA (Center for Functional Genomics in Arabidopsis) for the En lines. We are grateful to our colleagues, particularly Leo Gälweiler, Niko Geldner, Matthias Godde, and Kathrin Schrick for critical reading of the manuscript. This work was supported by a fellowship of the Deutscher Akademischer Austauschdienset (J.F.), the Deutsche Forschungsgemeinschaft (Schwerpunktprogramm Phytohormone), the European Communities Biotechnology Programs, the Fonds der Chemischen Industrie, and the INCO-Copernicus Program.","pmid":1,"extern":"1","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","intvolume":"       108","day":"08","publication_status":"published","oa_version":"None","page":"661 - 673","abstract":[{"lang":"eng","text":"In contrast to animals, little is known about pattern formation in plants. Physiological and genetic data suggest the involvement of the phytohormone auxin in this process. Here, we characterize a novel member of the PIN family of putative auxin efflux carriers, Arabidopsis PIN4, that is localized in developing and mature root meristems. Atpin4 mutants are defective in establishment and maintenance of endogenous auxin gradients, fail to canalize externally applied auxin, and display various patterning defects in both embryonic and seedling roots. We propose a role for AtPIN4 in generating a sink for auxin below the quiescent center of the root meristem that is essential for auxin distribution and patterning."}],"date_updated":"2023-07-17T11:57:40Z","status":"public","publication":"Cell","title":"AtPIN4 mediates sink-driven auxin gradients and root patterning in Arabidopsis","external_id":{"pmid":["11893337"]},"citation":{"apa":"Friml, J., Benková, E., Blilou, I., Wiśniewska, J., Hamann, T., Ljung, K., … Palme, K. (2002). AtPIN4 mediates sink-driven auxin gradients and root patterning in Arabidopsis. <i>Cell</i>. Cell Press. <a href=\"https://doi.org/10.1016/S0092-8674(02)00656-6\">https://doi.org/10.1016/S0092-8674(02)00656-6</a>","ista":"Friml J, Benková E, Blilou I, Wiśniewska J, Hamann T, Ljung K, Woody S, Sandberg G, Scheres B, Jürgens G, Palme K. 2002. AtPIN4 mediates sink-driven auxin gradients and root patterning in Arabidopsis. Cell. 108(5), 661–673.","mla":"Friml, Jiří, et al. “AtPIN4 Mediates Sink-Driven Auxin Gradients and Root Patterning in Arabidopsis.” <i>Cell</i>, vol. 108, no. 5, Cell Press, 2002, pp. 661–73, doi:<a href=\"https://doi.org/10.1016/S0092-8674(02)00656-6\">10.1016/S0092-8674(02)00656-6</a>.","short":"J. Friml, E. Benková, I. Blilou, J. Wiśniewska, T. Hamann, K. Ljung, S. Woody, G. Sandberg, B. Scheres, G. Jürgens, K. Palme, Cell 108 (2002) 661–673.","ama":"Friml J, Benková E, Blilou I, et al. AtPIN4 mediates sink-driven auxin gradients and root patterning in Arabidopsis. <i>Cell</i>. 2002;108(5):661-673. doi:<a href=\"https://doi.org/10.1016/S0092-8674(02)00656-6\">10.1016/S0092-8674(02)00656-6</a>","chicago":"Friml, Jiří, Eva Benková, Ikram Blilou, Justyna Wiśniewska, Thorsten Hamann, Karin Ljung, Scott Woody, et al. “AtPIN4 Mediates Sink-Driven Auxin Gradients and Root Patterning in Arabidopsis.” <i>Cell</i>. Cell Press, 2002. <a href=\"https://doi.org/10.1016/S0092-8674(02)00656-6\">https://doi.org/10.1016/S0092-8674(02)00656-6</a>.","ieee":"J. Friml <i>et al.</i>, “AtPIN4 mediates sink-driven auxin gradients and root patterning in Arabidopsis,” <i>Cell</i>, vol. 108, no. 5. Cell Press, pp. 661–673, 2002."},"scopus_import":"1","issue":"5"},{"day":"01","page":"273 - 284","date_published":"2002-06-01T00:00:00Z","publication_status":"published","oa_version":"None","abstract":[{"lang":"eng","text":"Polar auxin transport controls multiple aspects of plant development including differential growth, embryo and root patterning and vascular tissue differentiation. Identification of proteins involved in this process and availability of new tools enabling `visualization' of auxin and auxin routes in planta largely contributed to the significant progress that has recently been made. New data support classical concepts, but several recent findings are likely to challenge our view on the mechanism of auxin transport. The aim of this review is to provide a comprehensive overview of the polar auxin transport field. It starts with classical models resulting from physiological studies, describes the genetic contributions and discusses the molecular basis of auxin influx and efflux. Finally, selected questions are presented in the context of developmental biology, integrating available data from different fields."}],"author":[{"orcid":"0000-0002-8302-7596","last_name":"Friml","id":"4159519E-F248-11E8-B48F-1D18A9856A87","full_name":"Friml, Jirí","first_name":"Jirí"},{"last_name":"Palme","first_name":"Klaus","full_name":"Palme, Klaus"}],"_id":"2991","status":"public","type":"journal_article","doi":"10.1023/A:1015248926412","language":[{"iso":"eng"}],"year":"2002","publisher":"Springer","date_updated":"2021-01-12T07:40:17Z","publication":"Plant Molecular Biology","title":"Polar auxin transport - Old questions and new concepts?","volume":49,"month":"06","publist_id":"3712","quality_controlled":"1","issue":"3-4","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","extern":"1","intvolume":"        49","date_created":"2018-12-11T12:00:44Z","citation":{"mla":"Friml, Jiří, and Klaus Palme. “Polar Auxin Transport - Old Questions and New Concepts?” <i>Plant Molecular Biology</i>, vol. 49, no. 3–4, Springer, 2002, pp. 273–84, doi:<a href=\"https://doi.org/10.1023/A:1015248926412\">10.1023/A:1015248926412</a>.","short":"J. Friml, K. Palme, Plant Molecular Biology 49 (2002) 273–284.","ista":"Friml J, Palme K. 2002. Polar auxin transport - Old questions and new concepts? Plant Molecular Biology. 49(3–4), 273–284.","apa":"Friml, J., &#38; Palme, K. (2002). Polar auxin transport - Old questions and new concepts? <i>Plant Molecular Biology</i>. Springer. <a href=\"https://doi.org/10.1023/A:1015248926412\">https://doi.org/10.1023/A:1015248926412</a>","ama":"Friml J, Palme K. Polar auxin transport - Old questions and new concepts? <i>Plant Molecular Biology</i>. 2002;49(3-4):273-284. doi:<a href=\"https://doi.org/10.1023/A:1015248926412\">10.1023/A:1015248926412</a>","chicago":"Friml, Jiří, and Klaus Palme. “Polar Auxin Transport - Old Questions and New Concepts?” <i>Plant Molecular Biology</i>. Springer, 2002. <a href=\"https://doi.org/10.1023/A:1015248926412\">https://doi.org/10.1023/A:1015248926412</a>.","ieee":"J. Friml and K. Palme, “Polar auxin transport - Old questions and new concepts?,” <i>Plant Molecular Biology</i>, vol. 49, no. 3–4. Springer, pp. 273–284, 2002."}},{"citation":{"ista":"Hippenmeyer S, Shneider N, Birchmeier C, Burden S, Jessell T, Arber S. 2002. A role for Neuregulin1 signaling in muscle spindle differentiation. Neuron. 36(6), 1035–1049.","mla":"Hippenmeyer, Simon, et al. “A Role for Neuregulin1 Signaling in Muscle Spindle Differentiation.” <i>Neuron</i>, vol. 36, no. 6, Elsevier, 2002, pp. 1035–49, doi:<a href=\"https://doi.org/10.1016/S0896-6273(02)01101-7\">10.1016/S0896-6273(02)01101-7</a>.","short":"S. Hippenmeyer, N. Shneider, C. Birchmeier, S. Burden, T. Jessell, S. Arber, Neuron 36 (2002) 1035–1049.","apa":"Hippenmeyer, S., Shneider, N., Birchmeier, C., Burden, S., Jessell, T., &#38; Arber, S. (2002). A role for Neuregulin1 signaling in muscle spindle differentiation. <i>Neuron</i>. Elsevier. <a href=\"https://doi.org/10.1016/S0896-6273(02)01101-7\">https://doi.org/10.1016/S0896-6273(02)01101-7</a>","ama":"Hippenmeyer S, Shneider N, Birchmeier C, Burden S, Jessell T, Arber S. A role for Neuregulin1 signaling in muscle spindle differentiation. <i>Neuron</i>. 2002;36(6):1035-1049. doi:<a href=\"https://doi.org/10.1016/S0896-6273(02)01101-7\">10.1016/S0896-6273(02)01101-7</a>","chicago":"Hippenmeyer, Simon, Neil Shneider, Carmen Birchmeier, Steven Burden, Thomas Jessell, and Silvia Arber. “A Role for Neuregulin1 Signaling in Muscle Spindle Differentiation.” <i>Neuron</i>. Elsevier, 2002. <a href=\"https://doi.org/10.1016/S0896-6273(02)01101-7\">https://doi.org/10.1016/S0896-6273(02)01101-7</a>.","ieee":"S. Hippenmeyer, N. Shneider, C. Birchmeier, S. Burden, T. Jessell, and S. Arber, “A role for Neuregulin1 signaling in muscle spindle differentiation,” <i>Neuron</i>, vol. 36, no. 6. Elsevier, pp. 1035–1049, 2002."},"scopus_import":"1","issue":"6","publication":"Neuron","title":"A role for Neuregulin1 signaling in muscle spindle differentiation","external_id":{"pmid":["12495620"]},"date_updated":"2023-07-17T11:46:43Z","status":"public","day":"19","oa_version":"None","page":"1035 - 1049","publication_status":"published","abstract":[{"lang":"eng","text":"The maturation of synaptic structures depends on inductive interactions between axons and their prospective targets. One example of such an interaction is the influence of proprioceptive sensory axons on the differentiation of muscle spindles. We have monitored the expression of three transcription factors, Egr3, Pea3, and Erm, that delineate early muscle spindle development in an assay of muscle spindle-inducing signals. We provide genetic evidence that Neuregulin1 (Nrg1) is required for proprioceptive afferent-evoked induction of muscle spindle differentiation in the mouse. Ig-Nrg1 isoforms are preferentially expressed by proprioceptive sensory neurons and are sufficient to induce muscle spindle differentiation in vivo, whereas CRD-Nrg1 isoforms are broadly expressed in sensory and motor neurons but are not required for muscle spindle induction."}],"date_created":"2018-12-11T12:01:37Z","acknowledgement":"We thank L. Role for generously providing the CRD-Nrg1 mutant allele for these studies, L. Parada and D. Anderson for sharing the TrkC and Ngn1 mouse strains, W. Tourtellotte for providing Egr3 mutant mice, E. Avetisova for expert technical assistance, X. Yang for experimental help in the initial phase of these studies, A. Garratt for advice with ErbB antibodies, and L. Role and G. Fischbach for helpful discussions. The CRD-Nrg1 mutant allele was generated in the lab of Dr. Lorna Role, with the support of NIH grant NS29071. S.A. and S.H. were supported by a grant from the Swiss National Science Foundation and the Kanton of Basel-Stadt. S.J.B. was supported by grants from the NINDS. N.A.S. was supported by a Howard Hughes Medical Institute Postdoctoral Fellowship for Physicians and a Career Development Award from the NINDS. T.M.J. was supported by grants from NINDS and is an Investigator of the Howard Hughes Medical Institute.","pmid":1,"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","extern":"1","article_processing_charge":"No","intvolume":"        36","month":"12","publication_identifier":{"issn":["0896-6273"]},"publist_id":"3558","quality_controlled":"1","article_type":"original","volume":36,"doi":"10.1016/S0896-6273(02)01101-7","language":[{"iso":"eng"}],"year":"2002","publisher":"Elsevier","type":"journal_article","author":[{"orcid":"0000-0003-2279-1061","id":"37B36620-F248-11E8-B48F-1D18A9856A87","last_name":"Hippenmeyer","full_name":"Hippenmeyer, Simon","first_name":"Simon"},{"last_name":"Shneider","full_name":"Shneider, Neil","first_name":"Neil"},{"first_name":"Carmen","full_name":"Birchmeier, Carmen","last_name":"Birchmeier"},{"last_name":"Burden","full_name":"Burden, Steven","first_name":"Steven"},{"first_name":"Thomas","full_name":"Jessell, Thomas","last_name":"Jessell"},{"first_name":"Silvia","full_name":"Arber, Silvia","last_name":"Arber"}],"_id":"3140","date_published":"2002-12-19T00:00:00Z"},{"volume":4,"article_type":"original","month":"07","quality_controlled":"1","publication_identifier":{"eissn":["1476-4679"],"issn":["1465-7392"]},"user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","article_processing_charge":"No","extern":"1","keyword":["Cell Biology"],"intvolume":"         4","date_created":"2022-04-07T07:57:19Z","pmid":1,"date_published":"2002-07-01T00:00:00Z","author":[{"orcid":"0000-0002-2111-992X","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","last_name":"HETZER","full_name":"HETZER, Martin W","first_name":"Martin W"},{"full_name":"Gruss, Oliver J.","first_name":"Oliver J.","last_name":"Gruss"},{"last_name":"Mattaj","full_name":"Mattaj, Iain W.","first_name":"Iain W."}],"_id":"11123","type":"journal_article","language":[{"iso":"eng"}],"doi":"10.1038/ncb0702-e177","publisher":"Springer Nature","year":"2002","publication":"Nature Cell Biology","external_id":{"pmid":["12105431"]},"title":"The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly","issue":"7","scopus_import":"1","citation":{"mla":"Hetzer, Martin, et al. “The Ran GTPase as a Marker of Chromosome Position in Spindle Formation and Nuclear Envelope Assembly.” <i>Nature Cell Biology</i>, vol. 4, no. 7, Springer Nature, 2002, pp. E177–84, doi:<a href=\"https://doi.org/10.1038/ncb0702-e177\">10.1038/ncb0702-e177</a>.","ista":"Hetzer M, Gruss OJ, Mattaj IW. 2002. The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly. Nature Cell Biology. 4(7), E177–E184.","short":"M. Hetzer, O.J. Gruss, I.W. Mattaj, Nature Cell Biology 4 (2002) E177–E184.","apa":"Hetzer, M., Gruss, O. J., &#38; Mattaj, I. W. (2002). The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly. <i>Nature Cell Biology</i>. Springer Nature. <a href=\"https://doi.org/10.1038/ncb0702-e177\">https://doi.org/10.1038/ncb0702-e177</a>","ama":"Hetzer M, Gruss OJ, Mattaj IW. The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly. <i>Nature Cell Biology</i>. 2002;4(7):E177-E184. doi:<a href=\"https://doi.org/10.1038/ncb0702-e177\">10.1038/ncb0702-e177</a>","chicago":"Hetzer, Martin, Oliver J. Gruss, and Iain W. Mattaj. “The Ran GTPase as a Marker of Chromosome Position in Spindle Formation and Nuclear Envelope Assembly.” <i>Nature Cell Biology</i>. Springer Nature, 2002. <a href=\"https://doi.org/10.1038/ncb0702-e177\">https://doi.org/10.1038/ncb0702-e177</a>.","ieee":"M. Hetzer, O. J. Gruss, and I. W. Mattaj, “The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly,” <i>Nature Cell Biology</i>, vol. 4, no. 7. Springer Nature, pp. E177–E184, 2002."},"oa_version":"None","page":"E177-E184","publication_status":"published","day":"01","abstract":[{"text":"The small GTPase Ran is a key regulator of nucleocytoplasmic transport during interphase. The asymmetric distribution of the GTP-bound form of Ran across the nuclear envelope — that is, large quantities in the nucleus compared with small quantities in the cytoplasm — determines the directionality of many nuclear transport processes. Recent findings that Ran also functions in spindle formation and nuclear envelope assembly during mitosis suggest that Ran has a general role in chromatin-centred processes. Ran functions in these events as a signal for chromosome position.","lang":"eng"}],"status":"public","date_updated":"2022-07-18T08:58:03Z"},{"month":"07","quality_controlled":"1","publication_identifier":{"issn":["0960-9822"]},"volume":12,"article_type":"letter_note","date_created":"2022-04-07T07:57:31Z","pmid":1,"extern":"1","article_processing_charge":"No","user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","keyword":["General Agricultural and Biological Sciences","General Biochemistry","Genetics and Molecular Biology"],"intvolume":"        12","author":[{"last_name":"Bilbao-Cortés","first_name":"Daniel","full_name":"Bilbao-Cortés, Daniel"},{"first_name":"Martin W","full_name":"HETZER, Martin W","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","last_name":"HETZER","orcid":"0000-0002-2111-992X"},{"last_name":"Längst","full_name":"Längst, Gernot","first_name":"Gernot"},{"last_name":"Becker","first_name":"Peter B.","full_name":"Becker, Peter B."},{"first_name":"Iain W.","full_name":"Mattaj, Iain W.","last_name":"Mattaj"}],"oa":1,"_id":"11124","date_published":"2002-07-09T00:00:00Z","language":[{"iso":"eng"}],"doi":"10.1016/s0960-9822(02)00927-2","publisher":"Elsevier BV","year":"2002","type":"journal_article","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1016/S0960-9822(02)00927-2"}],"publication":"Current Biology","external_id":{"pmid":["12121625"]},"title":"Ran binds to chromatin by two distinct mechanisms","citation":{"chicago":"Bilbao-Cortés, Daniel, Martin Hetzer, Gernot Längst, Peter B. Becker, and Iain W. Mattaj. “Ran Binds to Chromatin by Two Distinct Mechanisms.” <i>Current Biology</i>. Elsevier BV, 2002. <a href=\"https://doi.org/10.1016/s0960-9822(02)00927-2\">https://doi.org/10.1016/s0960-9822(02)00927-2</a>.","ieee":"D. Bilbao-Cortés, M. Hetzer, G. Längst, P. B. Becker, and I. W. Mattaj, “Ran binds to chromatin by two distinct mechanisms,” <i>Current Biology</i>, vol. 12, no. 13. Elsevier BV, pp. 1151–1156, 2002.","apa":"Bilbao-Cortés, D., Hetzer, M., Längst, G., Becker, P. B., &#38; Mattaj, I. W. (2002). Ran binds to chromatin by two distinct mechanisms. <i>Current Biology</i>. Elsevier BV. <a href=\"https://doi.org/10.1016/s0960-9822(02)00927-2\">https://doi.org/10.1016/s0960-9822(02)00927-2</a>","mla":"Bilbao-Cortés, Daniel, et al. “Ran Binds to Chromatin by Two Distinct Mechanisms.” <i>Current Biology</i>, vol. 12, no. 13, Elsevier BV, 2002, pp. 1151–56, doi:<a href=\"https://doi.org/10.1016/s0960-9822(02)00927-2\">10.1016/s0960-9822(02)00927-2</a>.","short":"D. Bilbao-Cortés, M. Hetzer, G. Längst, P.B. Becker, I.W. Mattaj, Current Biology 12 (2002) 1151–1156.","ista":"Bilbao-Cortés D, Hetzer M, Längst G, Becker PB, Mattaj IW. 2002. Ran binds to chromatin by two distinct mechanisms. Current Biology. 12(13), 1151–1156.","ama":"Bilbao-Cortés D, Hetzer M, Längst G, Becker PB, Mattaj IW. Ran binds to chromatin by two distinct mechanisms. <i>Current Biology</i>. 2002;12(13):1151-1156. doi:<a href=\"https://doi.org/10.1016/s0960-9822(02)00927-2\">10.1016/s0960-9822(02)00927-2</a>"},"issue":"13","scopus_import":"1","publication_status":"published","oa_version":"Published Version","page":"1151-1156","day":"09","abstract":[{"text":"Ran GTPase plays important roles in nucleocytoplasmic transport in interphase [1, 2] and in both spindle formation and nuclear envelope (NE) assembly during mitosis [3, 4, 5]. The latter functions rely on the presence of high local concentrations of GTP-bound Ran near mitotic chromatin [3, 4, 5]. RanGTP localization has been proposed to result from the association of Ran's GDP/GTP exchange factor, RCC1, with chromatin [6, 7, 8, 9], but Ran is shown here to bind directly to chromatin in two modes, either dependent or independent of RCC1, and, where bound, to increase the affinity of chromatin for NE membranes. We propose that the Ran binding capacity of chromatin contributes to localized spindle and NE assembly.","lang":"eng"}],"date_updated":"2022-07-18T08:58:05Z","status":"public"},{"month":"01","publication_identifier":{"issn":["0022-2844"]},"publist_id":"6787","quality_controlled":"1","volume":55,"article_type":"original","date_created":"2018-12-11T11:48:53Z","acknowledgement":"We are thankful to J.A. Southerland and P.L. Jiang for technical assistance in DNA sequencing, as well as to Y.I. Pavlov for helpful discussions. This work was supported by public Health Service Research Grant AI45135 from the Institute of Allergy and Infectious Diseases, National Institutes of Health.","pmid":1,"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","extern":"1","article_processing_charge":"No","intvolume":"        55","author":[{"full_name":"Perelygin, Andrey","first_name":"Andrey","last_name":"Perelygin"},{"full_name":"Kondrashov, Fyodor","first_name":"Fyodor","orcid":"0000-0001-8243-4694","id":"44FDEF62-F248-11E8-B48F-1D18A9856A87","last_name":"Kondrashov"},{"last_name":"Rogozin","first_name":"Igor","full_name":"Rogozin, Igor"},{"first_name":"Margo","full_name":"Brinton, Margo","last_name":"Brinton"}],"_id":"859","date_published":"2002-01-01T00:00:00Z","doi":"10.1007/s00239-002-2318-0","language":[{"iso":"eng"}],"year":"2002","publisher":"Springer","type":"journal_article","publication":"Journal of Molecular Evolution","title":"Evolution of the mouse polyubiquitin C gene","external_id":{"pmid":["12107596"]},"citation":{"ama":"Perelygin A, Kondrashov F, Rogozin I, Brinton M. Evolution of the mouse polyubiquitin C gene. <i>Journal of Molecular Evolution</i>. 2002;55(2):202-210. doi:<a href=\"https://doi.org/10.1007/s00239-002-2318-0\">10.1007/s00239-002-2318-0</a>","short":"A. Perelygin, F. Kondrashov, I. Rogozin, M. Brinton, Journal of Molecular Evolution 55 (2002) 202–210.","mla":"Perelygin, Andrey, et al. “Evolution of the Mouse Polyubiquitin C Gene.” <i>Journal of Molecular Evolution</i>, vol. 55, no. 2, Springer, 2002, pp. 202–10, doi:<a href=\"https://doi.org/10.1007/s00239-002-2318-0\">10.1007/s00239-002-2318-0</a>.","apa":"Perelygin, A., Kondrashov, F., Rogozin, I., &#38; Brinton, M. (2002). Evolution of the mouse polyubiquitin C gene. <i>Journal of Molecular Evolution</i>. Springer. <a href=\"https://doi.org/10.1007/s00239-002-2318-0\">https://doi.org/10.1007/s00239-002-2318-0</a>","ista":"Perelygin A, Kondrashov F, Rogozin I, Brinton M. 2002. Evolution of the mouse polyubiquitin C gene. Journal of Molecular Evolution. 55(2), 202–210.","ieee":"A. Perelygin, F. Kondrashov, I. Rogozin, and M. Brinton, “Evolution of the mouse polyubiquitin C gene,” <i>Journal of Molecular Evolution</i>, vol. 55, no. 2. Springer, pp. 202–210, 2002.","chicago":"Perelygin, Andrey, Fyodor Kondrashov, Igor Rogozin, and Margo Brinton. “Evolution of the Mouse Polyubiquitin C Gene.” <i>Journal of Molecular Evolution</i>. Springer, 2002. <a href=\"https://doi.org/10.1007/s00239-002-2318-0\">https://doi.org/10.1007/s00239-002-2318-0</a>."},"scopus_import":"1","issue":"2","day":"01","page":"202 - 210","publication_status":"published","oa_version":"None","abstract":[{"text":"The polymeric ubiquitin (poly-u) genes are composed of tandem 228-bp repeats with no spacer sequences between individual monomer units. Ubiquitin is one of the most conserved proteins known to date, and the individual units within a number of poly-u genes are significantly more similar to each other than would be expected if each unit evolved independently. It has been proposed that the rather striking similarity among poly-u monomers in some lineages is caused by a series of homogenization events. Here we report the sequences of the polyubiquitin-C (Ubc) genes in two mouse strains. Analysis of these sequences, as well as those of the previously reported Chinese hamster and rat poly-u genes, supports the assertion that the homogenization of the ubiquitin-C gene in rodents is due to unequal crossing-over events. The sequence divergence of noncoding DNA was used to estimate the frequency of unequal crossing-over events (6.3 x 10-5 events per generation) in the Ubc gene, as well as to provide evidence of apparent selection in the poly-u gene.","lang":"eng"}],"date_updated":"2023-07-26T12:01:34Z","status":"public"},{"title":"Selection in the evolution of gene duplications ","external_id":{"pmid":["11864370"]},"publication":"Genome Biology","main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC65685/","open_access":"1"}],"scopus_import":"1","issue":"2","citation":{"ama":"Kondrashov F, Rogozin I, Wolf Y, Koonin E. Selection in the evolution of gene duplications . <i>Genome Biology</i>. 2002;3(2). doi:<a href=\"https://doi.org/10.1186/gb-2002-3-2-research0008\">10.1186/gb-2002-3-2-research0008</a>","ista":"Kondrashov F, Rogozin I, Wolf Y, Koonin E. 2002. Selection in the evolution of gene duplications . Genome Biology. 3(2).","apa":"Kondrashov, F., Rogozin, I., Wolf, Y., &#38; Koonin, E. (2002). Selection in the evolution of gene duplications . <i>Genome Biology</i>. BioMed Central. <a href=\"https://doi.org/10.1186/gb-2002-3-2-research0008\">https://doi.org/10.1186/gb-2002-3-2-research0008</a>","short":"F. Kondrashov, I. Rogozin, Y. Wolf, E. Koonin, Genome Biology 3 (2002).","mla":"Kondrashov, Fyodor, et al. “Selection in the Evolution of Gene Duplications .” <i>Genome Biology</i>, vol. 3, no. 2, BioMed Central, 2002, doi:<a href=\"https://doi.org/10.1186/gb-2002-3-2-research0008\">10.1186/gb-2002-3-2-research0008</a>.","ieee":"F. Kondrashov, I. Rogozin, Y. Wolf, and E. Koonin, “Selection in the evolution of gene duplications ,” <i>Genome Biology</i>, vol. 3, no. 2. BioMed Central, 2002.","chicago":"Kondrashov, Fyodor, Igor Rogozin, Yuri Wolf, and Eugene Koonin. “Selection in the Evolution of Gene Duplications .” <i>Genome Biology</i>. BioMed Central, 2002. <a href=\"https://doi.org/10.1186/gb-2002-3-2-research0008\">https://doi.org/10.1186/gb-2002-3-2-research0008</a>."},"abstract":[{"lang":"eng","text":"BACKGROUND: Gene duplications have a major role in the evolution of new biological functions. Theoretical studies often assume that a duplication per se is selectively neutral and that, following a duplication, one of the gene copies is freed from purifying (stabilizing) selection, which creates the potential for evolution of a new function. RESULTS: In search of systematic evidence of accelerated evolution after duplication, we used data from 26 bacterial, six archaeal, and seven eukaryotic genomes to compare the mode and strength of selection acting on recently duplicated genes (paralogs) and on similarly diverged, unduplicated orthologous genes in different species. We find that the ratio of nonsynonymous to synonymous substitutions (Kn/Ks) in most paralogous pairs is &lt;&lt;1 and that paralogs typically evolve at similar rates, without significant asymmetry, indicating that both paralogs produced by a duplication are subject to purifying selection. This selection is, however, substantially weaker than the purifying selection affecting unduplicated orthologs that have diverged to the same extent as the analyzed paralogs. Most of the recently duplicated genes appear to be involved in various forms of environmental response; in particular, many of them encode membrane and secreted proteins. CONCLUSIONS: The results of this analysis indicate that recently duplicated paralogs evolve faster than orthologs with the same level of divergence and similar functions, but apparently do not experience a phase of neutral evolution. We hypothesize that gene duplications that persist in an evolving lineage are beneficial from the time of their origin, due primarily to a protein dosage effect in response to variable environmental conditions; duplications are likely to give rise to new functions at a later phase of their evolution once a higher level of divergence is reached."}],"day":"01","oa_version":"Published Version","publication_status":"published","status":"public","date_updated":"2023-07-26T11:48:27Z","volume":3,"article_type":"original","publist_id":"6781","publication_identifier":{"issn":["1465-6906"]},"quality_controlled":"1","month":"01","intvolume":"         3","article_processing_charge":"No","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","extern":"1","acknowledgement":"We are grateful to A.S. Kondrashov for numerous helpful suggestions, to I. King Jordan, M.A. Roytberg, J.L. Spouge and D.A. Kondrashov for useful discussions and to A.S. Kondrashov, I. King Jordan and D.J. Lipman for critical reading of the manuscript.","pmid":1,"date_created":"2018-12-11T11:48:57Z","date_published":"2002-01-01T00:00:00Z","_id":"871","oa":1,"author":[{"first_name":"Fyodor","full_name":"Kondrashov, Fyodor","orcid":"0000-0001-8243-4694","last_name":"Kondrashov","id":"44FDEF62-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Rogozin, Igor","first_name":"Igor","last_name":"Rogozin"},{"first_name":"Yuri","full_name":"Wolf, Yuri","last_name":"Wolf"},{"first_name":"Eugene","full_name":"Koonin, Eugene","last_name":"Koonin"}],"type":"journal_article","year":"2002","publisher":"BioMed Central","doi":"10.1186/gb-2002-3-2-research0008","language":[{"iso":"eng"}]},{"article_type":"original","volume":99,"publist_id":"6763","publication_identifier":{"issn":["0027-8424"]},"quality_controlled":"1","month":"11","intvolume":"        99","article_processing_charge":"No","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","extern":"1","pmid":1,"date_created":"2018-12-11T11:49:01Z","date_published":"2002-11-12T00:00:00Z","_id":"885","oa":1,"author":[{"last_name":"Kondrashov","first_name":"Alexey","full_name":"Kondrashov, Alexey"},{"first_name":"Shamil","full_name":"Sunyaev, Shamil","last_name":"Sunyaev"},{"first_name":"Fyodor","full_name":"Kondrashov, Fyodor","id":"44FDEF62-F248-11E8-B48F-1D18A9856A87","last_name":"Kondrashov","orcid":"0000-0001-8243-4694"}],"type":"journal_article","year":"2002","publisher":"National Academy of Sciences","doi":"10.1073/pnas.232565499","language":[{"iso":"eng"}],"title":"Dobzhansky-Muller incompatibilities in protein evolution","external_id":{"pmid":["12403824"]},"publication":"PNAS","main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC137512/","open_access":"1"}],"scopus_import":"1","issue":"23","citation":{"ama":"Kondrashov A, Sunyaev S, Kondrashov F. Dobzhansky-Muller incompatibilities in protein evolution. <i>PNAS</i>. 2002;99(23):14878-14883. doi:<a href=\"https://doi.org/10.1073/pnas.232565499\">10.1073/pnas.232565499</a>","apa":"Kondrashov, A., Sunyaev, S., &#38; Kondrashov, F. (2002). Dobzhansky-Muller incompatibilities in protein evolution. <i>PNAS</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.232565499\">https://doi.org/10.1073/pnas.232565499</a>","ista":"Kondrashov A, Sunyaev S, Kondrashov F. 2002. Dobzhansky-Muller incompatibilities in protein evolution. PNAS. 99(23), 14878–14883.","short":"A. Kondrashov, S. Sunyaev, F. Kondrashov, PNAS 99 (2002) 14878–14883.","mla":"Kondrashov, Alexey, et al. “Dobzhansky-Muller Incompatibilities in Protein Evolution.” <i>PNAS</i>, vol. 99, no. 23, National Academy of Sciences, 2002, pp. 14878–83, doi:<a href=\"https://doi.org/10.1073/pnas.232565499\">10.1073/pnas.232565499</a>.","ieee":"A. Kondrashov, S. Sunyaev, and F. Kondrashov, “Dobzhansky-Muller incompatibilities in protein evolution,” <i>PNAS</i>, vol. 99, no. 23. National Academy of Sciences, pp. 14878–14883, 2002.","chicago":"Kondrashov, Alexey, Shamil Sunyaev, and Fyodor Kondrashov. “Dobzhansky-Muller Incompatibilities in Protein Evolution.” <i>PNAS</i>. National Academy of Sciences, 2002. <a href=\"https://doi.org/10.1073/pnas.232565499\">https://doi.org/10.1073/pnas.232565499</a>."},"abstract":[{"text":"We study fitness landscape in the space of protein sequences by relating sets of human pathogenic missense mutations in 32 proteins to amino acid substitutions that occurred in the course of evolution of these proteins. On average, ≈10% of deviations of a nonhuman protein from its human ortholog are compensated pathogenic deviations (CPDs), i.e., are caused by an amino acid substitution that, at this site, would be pathogenic to humans. Normal functioning of a CPD-containing protein must be caused by other, compensatory deviations of the nonhuman species from humans. Together, a CPD and the corresponding compensatory deviation form a Dobzhansky-Muller incompatibility that can be visualized as the corner on a fitness ridge. Thus, proteins evolve along fitness ridges which contain only ≈10 steps between sucessive corners. The fraction of CPDs among all deviations of a protein from its human ortholog does not increase with the evolutionary distance between the proteins, indicating that subtitutions that carry evolving proteins around these corners occur in rapid succession, driven by positive selection. Data on fitness of interspecies hybrids suggest that the compensatory change that makes a CPD fit usually occurs within the same protein. Data on protein structures and on cooccurrence of amino acids at different sites of multiple orthologous proteins often make it possible to provisionally identify the substitution that compensates a partiCUlar CPD.","lang":"eng"}],"day":"12","page":"14878 - 14883","publication_status":"published","oa_version":"Published Version","status":"public","date_updated":"2023-07-26T09:48:37Z"},{"publication":"Nature Genetics","title":"Selection for short introns in highly expressed genes","external_id":{"pmid":["12134150"]},"scopus_import":"1","issue":"4","citation":{"ieee":"C. Castillo Davis, S. Mekhedov, D. Hartl, E. Koonin, and F. Kondrashov, “Selection for short introns in highly expressed genes,” <i>Nature Genetics</i>, vol. 31, no. 4. Nature Publishing Group, pp. 415–418, 2002.","chicago":"Castillo Davis, Cristian, Sergei Mekhedov, Daniel Hartl, Eugene Koonin, and Fyodor Kondrashov. “Selection for Short Introns in Highly Expressed Genes.” <i>Nature Genetics</i>. Nature Publishing Group, 2002. <a href=\"https://doi.org/10.1038/ng940\">https://doi.org/10.1038/ng940</a>.","ama":"Castillo Davis C, Mekhedov S, Hartl D, Koonin E, Kondrashov F. Selection for short introns in highly expressed genes. <i>Nature Genetics</i>. 2002;31(4):415-418. doi:<a href=\"https://doi.org/10.1038/ng940\">10.1038/ng940</a>","short":"C. Castillo Davis, S. Mekhedov, D. Hartl, E. Koonin, F. Kondrashov, Nature Genetics 31 (2002) 415–418.","ista":"Castillo Davis C, Mekhedov S, Hartl D, Koonin E, Kondrashov F. 2002. Selection for short introns in highly expressed genes. Nature Genetics. 31(4), 415–418.","mla":"Castillo Davis, Cristian, et al. “Selection for Short Introns in Highly Expressed Genes.” <i>Nature Genetics</i>, vol. 31, no. 4, Nature Publishing Group, 2002, pp. 415–18, doi:<a href=\"https://doi.org/10.1038/ng940\">10.1038/ng940</a>.","apa":"Castillo Davis, C., Mekhedov, S., Hartl, D., Koonin, E., &#38; Kondrashov, F. (2002). Selection for short introns in highly expressed genes. <i>Nature Genetics</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/ng940\">https://doi.org/10.1038/ng940</a>"},"day":"01","oa_version":"None","page":"415 - 418","publication_status":"published","abstract":[{"lang":"eng","text":"Transcription is a slow and expensive process: in eukaryotes, approximately 20 nucleotides can be transcribed per second at the expense of at least two ATP molecules per nucleotide. Thus, at least for highly expressed genes, transcription of long introns, which are particularly common in mammals, is costly. Using data on the expression of genes that encode proteins in Caenorhabditis elegans and Homo sapiens, we show that introns in highly expressed genes are substantially shorter than those in genes that are expressed at low levels. This difference is greater in humans, such that introns are, on average, 14 times shorter in highly expressed genes than in genes with low expression, whereas in C. Elegans the difference in intron length is only twofold. In contrast, the density of introns in a gene does not strongly depend on the level of gene expression. Thus, natural selection appears to favor short introns in highly expressed genes to minimize the cost of transcription and other molecular processes, such as splicing.\r\n"}],"status":"public","date_updated":"2023-07-26T09:45:30Z","article_type":"original","volume":31,"month":"08","publist_id":"6751","quality_controlled":"1","extern":"1","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","intvolume":"        31","date_created":"2018-12-11T11:49:05Z","acknowledgement":"We are grateful to A. Kondrashov, I. Rogozin and A. Feldman for reading the manuscript and P. Bouman, J. Cherry, J. Blumensteil and T. Kim for discussion.","pmid":1,"date_published":"2002-08-01T00:00:00Z","author":[{"last_name":"Castillo Davis","full_name":"Castillo Davis, Cristian","first_name":"Cristian"},{"last_name":"Mekhedov","first_name":"Sergei","full_name":"Mekhedov, Sergei"},{"last_name":"Hartl","first_name":"Daniel","full_name":"Hartl, Daniel"},{"full_name":"Koonin, Eugene","first_name":"Eugene","last_name":"Koonin"},{"first_name":"Fyodor","full_name":"Kondrashov, Fyodor","last_name":"Kondrashov","id":"44FDEF62-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8243-4694"}],"_id":"897","type":"journal_article","doi":"10.1038/ng940","language":[{"iso":"eng"}],"year":"2002","publisher":"Nature Publishing Group"},{"page":"191 - 198","publication_status":"published","oa_version":"None","date_published":"2002-06-28T00:00:00Z","day":"28","abstract":[{"text":"A new solvent-free composite polymer electrolyte consisting of high-molecular mass polyethylene oxide (PEO) filled with titanium oxide and containing LiI and I2 was developed. The introduction of the inorganic filler (TiO2 Degussa P25) into the polymer matrix produces dramatic morphological changes to the host polymer structure. Upon addition of the inorganic oxide, the surface roughness increases, with respect to the original polymer and in parallel, the fractal dimension decreases. Both the thermograms and the atomic force microscope (AFM) pictures confirm the amorphicity of the composite electrolyte. The polymer sub-units are held together in a parallel orientation, forming straight long chains of about 500 nm in width, along which TiO2 spherical particles of about 20-25 nm in diameter are distributed. The polymer chains separated by the titania particles are arranged in a three-dimensional, mechanically stable network, that creates free space and voids into which the iodide/triodide anions can easily migrate. All solid-state dye-sensitized solar cells fabricated using this composite electrolyte present high efficiencies (typical maximum incident photon to current efficiency (IPCE) as high as 40% at 520 nm and overall conversion efficiency (η) of 0.96% (Voc = 0.67 V, Jsc = 2.050 mA/cm2, FF = 39%) under direct solar irradiation. Further improvement of the photovoltaic performance is expected by optimization of the electrolyte parameters and of the cell assembly.","lang":"eng"}],"author":[{"last_name":"Katsaros","id":"38DB5788-F248-11E8-B48F-1D18A9856A87","first_name":"Georgios","full_name":"Katsaros, Georgios"},{"full_name":"Stergiopoulos, Thomas","first_name":"Thomas","last_name":"Stergiopoulos"},{"first_name":"Iannis","full_name":"Arabatzis, Iannis","last_name":"Arabatzis"},{"first_name":"Kyriaki","full_name":"Papadokostaki, Kyriaki","last_name":"Papadokostaki"},{"last_name":"Falaras","full_name":"Falaras, Polycarpos","first_name":"Polycarpos"}],"_id":"1737","status":"public","type":"journal_article","language":[{"iso":"eng"}],"doi":"10.1016/S1010-6030(02)00027-8","date_updated":"2023-07-26T08:56:55Z","publisher":"Elsevier","year":"2002","publication":"Journal of Photochemistry and Photobiology A: Chemistry","volume":149,"title":"A solvent-free composite polymer/inorganic oxide electrolyte for high efficiency solid-state dye-sensitized solar cells","month":"06","publication_identifier":{"issn":["1010-6030"]},"publist_id":"5387","extern":"1","article_processing_charge":"No","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","issue":"1-3","intvolume":"       149","date_created":"2018-12-11T11:53:44Z","citation":{"ista":"Katsaros G, Stergiopoulos T, Arabatzis I, Papadokostaki K, Falaras P. 2002. A solvent-free composite polymer/inorganic oxide electrolyte for high efficiency solid-state dye-sensitized solar cells. Journal of Photochemistry and Photobiology A: Chemistry. 149(1–3), 191–198.","apa":"Katsaros, G., Stergiopoulos, T., Arabatzis, I., Papadokostaki, K., &#38; Falaras, P. (2002). A solvent-free composite polymer/inorganic oxide electrolyte for high efficiency solid-state dye-sensitized solar cells. <i>Journal of Photochemistry and Photobiology A: Chemistry</i>. Elsevier. <a href=\"https://doi.org/10.1016/S1010-6030(02)00027-8\">https://doi.org/10.1016/S1010-6030(02)00027-8</a>","short":"G. Katsaros, T. Stergiopoulos, I. Arabatzis, K. Papadokostaki, P. Falaras, Journal of Photochemistry and Photobiology A: Chemistry 149 (2002) 191–198.","mla":"Katsaros, Georgios, et al. “A Solvent-Free Composite Polymer/Inorganic Oxide Electrolyte for High Efficiency Solid-State Dye-Sensitized Solar Cells.” <i>Journal of Photochemistry and Photobiology A: Chemistry</i>, vol. 149, no. 1–3, Elsevier, 2002, pp. 191–98, doi:<a href=\"https://doi.org/10.1016/S1010-6030(02)00027-8\">10.1016/S1010-6030(02)00027-8</a>.","ama":"Katsaros G, Stergiopoulos T, Arabatzis I, Papadokostaki K, Falaras P. A solvent-free composite polymer/inorganic oxide electrolyte for high efficiency solid-state dye-sensitized solar cells. <i>Journal of Photochemistry and Photobiology A: Chemistry</i>. 2002;149(1-3):191-198. doi:<a href=\"https://doi.org/10.1016/S1010-6030(02)00027-8\">10.1016/S1010-6030(02)00027-8</a>","chicago":"Katsaros, Georgios, Thomas Stergiopoulos, Iannis Arabatzis, Kyriaki Papadokostaki, and Polycarpos Falaras. “A Solvent-Free Composite Polymer/Inorganic Oxide Electrolyte for High Efficiency Solid-State Dye-Sensitized Solar Cells.” <i>Journal of Photochemistry and Photobiology A: Chemistry</i>. Elsevier, 2002. <a href=\"https://doi.org/10.1016/S1010-6030(02)00027-8\">https://doi.org/10.1016/S1010-6030(02)00027-8</a>.","ieee":"G. Katsaros, T. Stergiopoulos, I. Arabatzis, K. Papadokostaki, and P. Falaras, “A solvent-free composite polymer/inorganic oxide electrolyte for high efficiency solid-state dye-sensitized solar cells,” <i>Journal of Photochemistry and Photobiology A: Chemistry</i>, vol. 149, no. 1–3. Elsevier, pp. 191–198, 2002."},"acknowledgement":"Financial support from NCSR “Demokritos” (Dimoerevna 598 project), Empeirikeion Foundation and General Secretariat for Research and Technology of Greece (EPET II, Greece–France and Greece–Czech Republic bilateral collaboration projects) is also greatly acknowledged. G. Katsaros thanks the Greek State Scholarships Foundation (IKY) for fellowship allowance"},{"doi":"10.1117/12.452446","date_updated":"2021-01-12T06:52:53Z","publisher":"SPIE","year":"2002","status":"public","type":"conference","author":[{"last_name":"Falaras","first_name":"Polycarpos","full_name":"Falaras, Polycarpos"},{"last_name":"Chryssou","first_name":"Katerina","full_name":"Chryssou, Katerina"},{"full_name":"Stergiopoulos, Thomas","first_name":"Thomas","last_name":"Stergiopoulos"},{"first_name":"Ioannis","full_name":"Arabatzis, Ioannis M","last_name":"Arabatzis"},{"id":"38DB5788-F248-11E8-B48F-1D18A9856A87","last_name":"Katsaros","first_name":"Georgios","full_name":"Georgios Katsaros"},{"full_name":"Catalano, Vincent J","first_name":"Vincent","last_name":"Catalano"},{"full_name":"Kurtaran, Raif","first_name":"Raif","last_name":"Kurtaran"},{"first_name":"Anne","full_name":"Hugot-Le Goff, Anne","last_name":"Hugot Le Goff"},{"full_name":"Bernard, Marie C","first_name":"Marie","last_name":"Bernard"}],"_id":"1738","date_published":"2002-01-01T00:00:00Z","publication_status":"published","page":"125 - 135","day":"01","abstract":[{"text":"New dyes of the type Ru(II)(bdmpp)(bpy) [where bdmpp is 2,6-bis(3,5-dimethyl-N-pyrazoyl)pyridine and bpy is 2,2′-bipyridine-4,4′-dicarboxylic acid] are prepared and characterized by infra-red (IR), mass (MS) and electrospray mass spectroscopy (ES-MS) as well as 1H NMR (1D and 2D) spectroscopies. The compounds present broad and very high intensity MLCT absorption bands in the visible and can be chemically anchored on TiO2 films via ester-like linkage involving carboxylato groups. These complexes have been tested with success as potential molecular antennas in dye-sensitized solar cells. Both opaque and transparent nanocrystalline TiO2 thin film electrodes obtained by a doctor blade technique sensitized by these complexes were incorporated in a sandwich type regenerative photoelectrochemical solar cell containing 0.1M LiI +0.01M I2 in propylene carbonate as well as a platinized conductive glass counter electrode. The cell was characterized by Raman spectroscopy under anodic and cathodic bias. Two new vibration bands were observed in the lower frequency region. The first one at 112 cm-1 is due to tri-iodide formed on the photoactive electrode, and the second one at 167 cm-1 is a sign of the dye/iodide interaction and corresponds to a vibration in a chemically stable &quot;DI&quot; intermediate species. Under direct sunlight illumination (solar irradiance of 60 mW/cm2) by using a composite polymer solid state electrolyte, the cell ITO/TiO2/[Ru(II)(bdmpp)(bpy)(NCS)](PF6)/electrolyte/Pt-ITO produced a continuous photocurrent as high as 4.29mA/cm2, and gave IPCE values about half of the corresponding values obtained by the standard N3 dye under the same conditions. The photovoltage is about 600 mV and the overall energy conversion cell's efficiency is as high as 1.72%.","lang":"eng"}],"date_created":"2018-12-11T11:53:45Z","citation":{"ieee":"P. Falaras <i>et al.</i>, “Dye-sensitization of titanium dioxide thin films by Ru(II)-bpp-bpy complexes,” presented at the Organic Photovoltaics, 2002, vol. 4801, pp. 125–135.","chicago":"Falaras, Polycarpos, Katerina Chryssou, Thomas Stergiopoulos, Ioannis Arabatzis, Georgios Katsaros, Vincent Catalano, Raif Kurtaran, Anne Hugot Le Goff, and Marie Bernard. “Dye-Sensitization of Titanium Dioxide Thin Films by Ru(II)-Bpp-Bpy Complexes,” 4801:125–35. SPIE, 2002. <a href=\"https://doi.org/10.1117/12.452446\">https://doi.org/10.1117/12.452446</a>.","ama":"Falaras P, Chryssou K, Stergiopoulos T, et al. Dye-sensitization of titanium dioxide thin films by Ru(II)-bpp-bpy complexes. In: Vol 4801. SPIE; 2002:125-135. doi:<a href=\"https://doi.org/10.1117/12.452446\">10.1117/12.452446</a>","mla":"Falaras, Polycarpos, et al. <i>Dye-Sensitization of Titanium Dioxide Thin Films by Ru(II)-Bpp-Bpy Complexes</i>. Vol. 4801, SPIE, 2002, pp. 125–35, doi:<a href=\"https://doi.org/10.1117/12.452446\">10.1117/12.452446</a>.","short":"P. Falaras, K. Chryssou, T. Stergiopoulos, I. Arabatzis, G. Katsaros, V. Catalano, R. Kurtaran, A. Hugot Le Goff, M. Bernard, in:, SPIE, 2002, pp. 125–135.","apa":"Falaras, P., Chryssou, K., Stergiopoulos, T., Arabatzis, I., Katsaros, G., Catalano, V., … Bernard, M. (2002). Dye-sensitization of titanium dioxide thin films by Ru(II)-bpp-bpy complexes (Vol. 4801, pp. 125–135). Presented at the Organic Photovoltaics, SPIE. <a href=\"https://doi.org/10.1117/12.452446\">https://doi.org/10.1117/12.452446</a>","ista":"Falaras P, Chryssou K, Stergiopoulos T, Arabatzis I, Katsaros G, Catalano V, Kurtaran R, Hugot Le Goff A, Bernard M. 2002. Dye-sensitization of titanium dioxide thin films by Ru(II)-bpp-bpy complexes. Organic Photovoltaics vol. 4801, 125–135."},"extern":1,"conference":{"name":"Organic Photovoltaics"},"intvolume":"      4801","month":"01","quality_controlled":0,"publist_id":"5385","volume":4801,"title":"Dye-sensitization of titanium dioxide thin films by Ru(II)-bpp-bpy complexes"},{"citation":{"chicago":"Stergiopoulos, Thomas, Iannis Arabatzis, Georgios Katsaros, and Polycarpos Falaras. “Binary Polyethylene Oxide/Titania Solid-State Redox Electrolyte for Highly Efficient Nanocrystalline TiO2 Photoelectrochemical Cells.” <i>Nano Letters</i>. American Chemical Society, 2002. <a href=\"https://doi.org/10.1021/nl025798u\">https://doi.org/10.1021/nl025798u</a>.","ieee":"T. Stergiopoulos, I. Arabatzis, G. Katsaros, and P. Falaras, “Binary Polyethylene Oxide/Titania Solid-State Redox Electrolyte for Highly Efficient Nanocrystalline TiO2 Photoelectrochemical Cells,” <i>Nano Letters</i>, vol. 2, no. 11. American Chemical Society, pp. 1259–1261, 2002.","mla":"Stergiopoulos, Thomas, et al. “Binary Polyethylene Oxide/Titania Solid-State Redox Electrolyte for Highly Efficient Nanocrystalline TiO2 Photoelectrochemical Cells.” <i>Nano Letters</i>, vol. 2, no. 11, American Chemical Society, 2002, pp. 1259–61, doi:<a href=\"https://doi.org/10.1021/nl025798u\">10.1021/nl025798u</a>.","apa":"Stergiopoulos, T., Arabatzis, I., Katsaros, G., &#38; Falaras, P. (2002). Binary Polyethylene Oxide/Titania Solid-State Redox Electrolyte for Highly Efficient Nanocrystalline TiO2 Photoelectrochemical Cells. <i>Nano Letters</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/nl025798u\">https://doi.org/10.1021/nl025798u</a>","short":"T. Stergiopoulos, I. Arabatzis, G. Katsaros, P. Falaras, Nano Letters 2 (2002) 1259–1261.","ista":"Stergiopoulos T, Arabatzis I, Katsaros G, Falaras P. 2002. Binary Polyethylene Oxide/Titania Solid-State Redox Electrolyte for Highly Efficient Nanocrystalline TiO2 Photoelectrochemical Cells. Nano Letters. 2(11), 1259–1261.","ama":"Stergiopoulos T, Arabatzis I, Katsaros G, Falaras P. Binary Polyethylene Oxide/Titania Solid-State Redox Electrolyte for Highly Efficient Nanocrystalline TiO2 Photoelectrochemical Cells. <i>Nano Letters</i>. 2002;2(11):1259-1261. doi:<a href=\"https://doi.org/10.1021/nl025798u\">10.1021/nl025798u</a>"},"acknowledgement":"Financial support from NCSR “Demokritos” and GSRT-Greece is greatly acknowledged. ","date_created":"2018-12-11T11:53:45Z","intvolume":"         2","issue":"11","extern":1,"publist_id":"5386","quality_controlled":0,"month":"11","title":"Binary Polyethylene Oxide/Titania Solid-State Redox Electrolyte for Highly Efficient Nanocrystalline TiO2 Photoelectrochemical Cells","volume":2,"publication":"Nano Letters","year":"2002","publisher":"American Chemical Society","date_updated":"2021-01-12T06:52:53Z","doi":"10.1021/nl025798u","type":"journal_article","status":"public","_id":"1739","author":[{"last_name":"Stergiopoulos","first_name":"Thomas","full_name":"Stergiopoulos, Thomas"},{"full_name":"Arabatzis, Iannis M","first_name":"Iannis","last_name":"Arabatzis"},{"last_name":"Katsaros","id":"38DB5788-F248-11E8-B48F-1D18A9856A87","full_name":"Georgios Katsaros","first_name":"Georgios"},{"last_name":"Falaras","first_name":"Polycarpos","full_name":"Falaras, Polycarpos"}],"abstract":[{"text":"Poly(ethylene oxide)/titania polymer electrolyte based photoelectrochemical cells have been fabricated with Ru(dcbpy)2(NCS)2 complex as the sensitizer and nanoporous TiO2 films as photoanodes. The introduction of the titania filler into the poly(ethylene oxide) matrix reduces the crystallinity of the polymer and enhances the mobility of the 1-/13 - redox couple, resulting in outstanding overall conversion efficiency (4.2% under direct sunlight illumination) of the corresponding dye-sensitized nanocrystalline TiO2 solar cell, one of the best efficiencies reported to date for a solid-state device.","lang":"eng"}],"day":"01","date_published":"2002-11-01T00:00:00Z","publication_status":"published","page":"1259 - 1261"},{"citation":{"ieee":"T. D. Browning, “Equal Sums of Two kth Powers,” <i>Journal of Number Theory</i>, vol. 96, no. 2. Academic Press, pp. 293–318, 2002.","chicago":"Browning, Timothy D. “Equal Sums of Two Kth Powers.” <i>Journal of Number Theory</i>. Academic Press, 2002. <a href=\"https://doi.org/10.1006/jnth.2002.2800\">https://doi.org/10.1006/jnth.2002.2800</a>.","ama":"Browning TD. Equal Sums of Two kth Powers. <i>Journal of Number Theory</i>. 2002;96(2):293-318. doi:<a href=\"https://doi.org/10.1006/jnth.2002.2800\">10.1006/jnth.2002.2800</a>","apa":"Browning, T. D. (2002). Equal Sums of Two kth Powers. <i>Journal of Number Theory</i>. Academic Press. <a href=\"https://doi.org/10.1006/jnth.2002.2800\">https://doi.org/10.1006/jnth.2002.2800</a>","mla":"Browning, Timothy D. “Equal Sums of Two Kth Powers.” <i>Journal of Number Theory</i>, vol. 96, no. 2, Academic Press, 2002, pp. 293–318, doi:<a href=\"https://doi.org/10.1006/jnth.2002.2800\">10.1006/jnth.2002.2800</a>.","ista":"Browning TD. 2002. Equal Sums of Two kth Powers. Journal of Number Theory. 96(2), 293–318.","short":"T.D. Browning, Journal of Number Theory 96 (2002) 293–318."},"issue":"2","scopus_import":"1","title":"Equal Sums of Two kth Powers","publication":"Journal of Number Theory","date_updated":"2023-07-26T12:15:14Z","license":"https://creativecommons.org/licenses/by/4.0/","status":"public","abstract":[{"text":"Let k⩾5 be an integer, and let x⩾1 be an arbitrary real number. We derive a bound[Formula presented] for the number of positive integers less than or equal to x which can be represented as a sum of two non-negative coprime kth powers, in essentially more than one way.","lang":"eng"}],"publication_status":"published","oa_version":"Published Version","page":"293 - 318","day":"02","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"date_created":"2018-12-11T11:45:11Z","intvolume":"        96","article_processing_charge":"No","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","extern":"1","quality_controlled":"1","publication_identifier":{"issn":["0022-314X"]},"publist_id":"7708","month":"10","article_type":"original","volume":96,"publisher":"Academic Press","year":"2002","language":[{"iso":"eng"}],"doi":"10.1006/jnth.2002.2800","type":"journal_article","_id":"204","author":[{"full_name":"Browning, Timothy D","first_name":"Timothy D","last_name":"Browning","id":"35827D50-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8314-0177"}],"date_published":"2002-10-02T00:00:00Z"},{"day":"01","publication_status":"published","oa_version":"Published Version","date_published":"2002-01-01T00:00:00Z","page":"131 - 178","abstract":[{"text":"Now that the low temperature properties of quantum-mechanical many-body systems (bosons) at low density, ρ, can be examined experimentally it is appropriate to revisit some of the formulas deduced by many authors 4-5 decades ago. For systems with repulsive (i.e. positive) interaction potentials the experimental low temperature state and the ground state are effectively synonymous -- and this fact is used in all modeling. In such cases, the leading term in the energy/particle is 2πℏ2aρ/m where a is the scattering length of the two-body potential. Owing to the delicate and peculiar nature of bosonic correlations (such as the strange N7/5 law for charged bosons), four decades of research failed to establish this plausible formula rigorously. The only previous lower bound for the energy was found by Dyson in 1957, but it was 14 times too small. The correct asymptotic formula has recently been obtained by us and this work will be presented. The reason behind the mathematical difficulties will be emphasized. A different formula, postulated as late as 1971 by Schick, holds in two-dimensions and this, too, will be shown to be correct. With the aid of the methodology developed to prove the lower bound for the homogeneous gas, two other problems have been successfully addressed. One is the proof by us that the Gross-Pitaevskii equation correctly describes the ground state in the `traps' actually used in the experiments. For this system it is also possible to prove complete Bose condensation, as we have shown. Another topic is a proof that Foldy's 1961 theory of a high density Bose gas of charged particles correctly describes its ground state energy.","lang":"eng"}],"author":[{"first_name":"Élliott","full_name":"Lieb, Élliott","last_name":"Lieb"},{"first_name":"Jan","full_name":"Solovej, Jan","last_name":"Solovej"},{"orcid":"0000-0002-6781-0521","last_name":"Seiringer","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","first_name":"Robert","full_name":"Seiringer, Robert"},{"full_name":"Yngvason, Jakob","first_name":"Jakob","last_name":"Yngvason"}],"_id":"2338","oa":1,"status":"public","type":"book_chapter","doi":"10.48550/arXiv.math-ph/0204027","language":[{"iso":"eng"}],"year":"2002","publisher":"International Press","date_updated":"2023-07-26T08:43:46Z","publication":"Current Developments in Mathematics, 2001","title":"The ground state of the Bose gas","external_id":{"arxiv":["math-ph/0204027"]},"month":"01","publist_id":"4588","publication_identifier":{"isbn":["9781571461018"]},"main_file_link":[{"open_access":"1","url":"http://arxiv.org/abs/math-ph/0204027"}],"extern":"1","article_processing_charge":"No","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","alternative_title":["Current Developments in Mathematics"],"date_created":"2018-12-11T11:57:04Z","citation":{"chicago":"Lieb, Élliott, Jan Solovej, Robert Seiringer, and Jakob Yngvason. “The Ground State of the Bose Gas.” In <i>Current Developments in Mathematics, 2001</i>, 131–78. International Press, 2002. <a href=\"https://doi.org/10.48550/arXiv.math-ph/0204027\">https://doi.org/10.48550/arXiv.math-ph/0204027</a>.","ieee":"É. Lieb, J. Solovej, R. Seiringer, and J. Yngvason, “The ground state of the Bose gas,” in <i>Current Developments in Mathematics, 2001</i>, International Press, 2002, pp. 131–178.","ista":"Lieb É, Solovej J, Seiringer R, Yngvason J. 2002.The ground state of the Bose gas. In: Current Developments in Mathematics, 2001. Current Developments in Mathematics, , 131–178.","apa":"Lieb, É., Solovej, J., Seiringer, R., &#38; Yngvason, J. (2002). The ground state of the Bose gas. In <i>Current Developments in Mathematics, 2001</i> (pp. 131–178). International Press. <a href=\"https://doi.org/10.48550/arXiv.math-ph/0204027\">https://doi.org/10.48550/arXiv.math-ph/0204027</a>","short":"É. Lieb, J. Solovej, R. Seiringer, J. Yngvason, in:, Current Developments in Mathematics, 2001, International Press, 2002, pp. 131–178.","mla":"Lieb, Élliott, et al. “The Ground State of the Bose Gas.” <i>Current Developments in Mathematics, 2001</i>, International Press, 2002, pp. 131–78, doi:<a href=\"https://doi.org/10.48550/arXiv.math-ph/0204027\">10.48550/arXiv.math-ph/0204027</a>.","ama":"Lieb É, Solovej J, Seiringer R, Yngvason J. The ground state of the Bose gas. In: <i>Current Developments in Mathematics, 2001</i>. International Press; 2002:131-178. doi:<a href=\"https://doi.org/10.48550/arXiv.math-ph/0204027\">10.48550/arXiv.math-ph/0204027</a>"},"arxiv":1},{"publist_id":"4587","quality_controlled":0,"month":"01","title":"Symmetry breaking in a model of a rotating Bose gas","volume":307,"citation":{"apa":"Seiringer, R. (2002). Symmetry breaking in a model of a rotating Bose gas. In R. Weder, P. Exner, &#38; B. Grébert (Eds.) (Vol. 307, pp. 281–286). Presented at the QMath: Mathematical Results in Quantum Physics, World Scientific Publishing. <a href=\"https://doi.org/10.1090/conm/307\">https://doi.org/10.1090/conm/307</a>","short":"R. Seiringer, in:, R. Weder, P. Exner, B. Grébert (Eds.), World Scientific Publishing, 2002, pp. 281–286.","ista":"Seiringer R. 2002. Symmetry breaking in a model of a rotating Bose gas. QMath: Mathematical Results in Quantum Physics, Contemporary Mathematics, vol. 307, 281–286.","mla":"Seiringer, Robert. <i>Symmetry Breaking in a Model of a Rotating Bose Gas</i>. Edited by Richardo Weder et al., vol. 307, World Scientific Publishing, 2002, pp. 281–86, doi:<a href=\"https://doi.org/10.1090/conm/307\">10.1090/conm/307</a>.","ama":"Seiringer R. Symmetry breaking in a model of a rotating Bose gas. In: Weder R, Exner P, Grébert B, eds. Vol 307. World Scientific Publishing; 2002:281-286. doi:<a href=\"https://doi.org/10.1090/conm/307\">10.1090/conm/307</a>","chicago":"Seiringer, Robert. “Symmetry Breaking in a Model of a Rotating Bose Gas.” edited by Richardo Weder, Pavel Exner, and Benoit Grébert, 307:281–86. World Scientific Publishing, 2002. <a href=\"https://doi.org/10.1090/conm/307\">https://doi.org/10.1090/conm/307</a>.","ieee":"R. Seiringer, “Symmetry breaking in a model of a rotating Bose gas,” presented at the QMath: Mathematical Results in Quantum Physics, 2002, vol. 307, pp. 281–286."},"date_created":"2018-12-11T11:57:05Z","intvolume":"       307","alternative_title":["Contemporary Mathematics"],"editor":[{"first_name":"Richardo","full_name":"Weder, Richardo","last_name":"Weder"},{"last_name":"Exner","full_name":"Exner, Pavel","first_name":"Pavel"},{"last_name":"Grébert","first_name":"Benoit","full_name":"Grébert, Benoit"}],"conference":{"name":"QMath: Mathematical Results in Quantum Physics"},"extern":1,"_id":"2339","author":[{"orcid":"0000-0002-6781-0521","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","last_name":"Seiringer","full_name":"Robert Seiringer","first_name":"Robert"}],"day":"01","page":"281 - 286","date_published":"2002-01-01T00:00:00Z","publication_status":"published","year":"2002","publisher":"World Scientific Publishing","date_updated":"2021-01-12T06:56:53Z","doi":"10.1090/conm/307","type":"conference","status":"public"},{"date_created":"2018-12-11T11:57:08Z","citation":{"ieee":"É. Lieb and R. Seiringer, “Proof of Bose-Einstein condensation for dilute trapped gases,” <i>Physical Review Letters</i>, vol. 88, no. 17. American Physical Society, pp. 1704091–1704094, 2002.","chicago":"Lieb, Élliott, and Robert Seiringer. “Proof of Bose-Einstein Condensation for Dilute Trapped Gases.” <i>Physical Review Letters</i>. American Physical Society, 2002. <a href=\"https://doi.org/10.1103/PhysRevLett.88.170409\">https://doi.org/10.1103/PhysRevLett.88.170409</a>.","ama":"Lieb É, Seiringer R. Proof of Bose-Einstein condensation for dilute trapped gases. <i>Physical Review Letters</i>. 2002;88(17):1704091-1704094. doi:<a href=\"https://doi.org/10.1103/PhysRevLett.88.170409\">10.1103/PhysRevLett.88.170409</a>","ista":"Lieb É, Seiringer R. 2002. Proof of Bose-Einstein condensation for dilute trapped gases. Physical Review Letters. 88(17), 1704091–1704094.","apa":"Lieb, É., &#38; Seiringer, R. (2002). Proof of Bose-Einstein condensation for dilute trapped gases. <i>Physical Review Letters</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevLett.88.170409\">https://doi.org/10.1103/PhysRevLett.88.170409</a>","mla":"Lieb, Élliott, and Robert Seiringer. “Proof of Bose-Einstein Condensation for Dilute Trapped Gases.” <i>Physical Review Letters</i>, vol. 88, no. 17, American Physical Society, 2002, pp. 1704091–94, doi:<a href=\"https://doi.org/10.1103/PhysRevLett.88.170409\">10.1103/PhysRevLett.88.170409</a>.","short":"É. Lieb, R. Seiringer, Physical Review Letters 88 (2002) 1704091–1704094."},"issue":"17","extern":1,"intvolume":"        88","month":"04","quality_controlled":0,"main_file_link":[{"url":"http://arxiv.org/abs/math-ph/0112032","open_access":"1"}],"publist_id":"4577","publication":"Physical Review Letters","volume":88,"title":"Proof of Bose-Einstein condensation for dilute trapped gases","doi":"10.1103/PhysRevLett.88.170409","publisher":"American Physical Society","date_updated":"2021-01-12T06:56:56Z","year":"2002","status":"public","type":"journal_article","author":[{"first_name":"Élliott","full_name":"Lieb, Élliott H","last_name":"Lieb"},{"full_name":"Robert Seiringer","first_name":"Robert","last_name":"Seiringer","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6781-0521"}],"oa":1,"_id":"2349","publication_status":"published","date_published":"2002-04-29T00:00:00Z","page":"1704091 - 1704094","day":"29","abstract":[{"lang":"eng","text":"The Bose-Einstein condensation (BEC) of the ground state of bosonic atoms in a trap was discussed. The BEC was proved for bosons with two-body repulsive interaction potentials in the dilute limit, starting from the basic Schrodinger equation. The BEC was 100% into the state which minimized the Gross-Pitaevskii energy functional. The analysis also included rigorous proof of BEC in a physically realistic, continuum model."}]},{"arxiv":1,"citation":{"ista":"Hainzl C, Seiringer R. 2002. Mass renormalization and energy level shift in non-relativistic QED. Advances in Theoretical and Mathematical Physics. 6(5), 847–871.","apa":"Hainzl, C., &#38; Seiringer, R. (2002). Mass renormalization and energy level shift in non-relativistic QED. <i>Advances in Theoretical and Mathematical Physics</i>. International Press. <a href=\"https://doi.org/10.4310/ATMP.2002.v6.n5.a3\">https://doi.org/10.4310/ATMP.2002.v6.n5.a3</a>","mla":"Hainzl, Christian, and Robert Seiringer. “Mass Renormalization and Energy Level Shift in Non-Relativistic QED.” <i>Advances in Theoretical and Mathematical Physics</i>, vol. 6, no. 5, International Press, 2002, pp. 847–71, doi:<a href=\"https://doi.org/10.4310/ATMP.2002.v6.n5.a3\">10.4310/ATMP.2002.v6.n5.a3</a>.","short":"C. Hainzl, R. Seiringer, Advances in Theoretical and Mathematical Physics 6 (2002) 847–871.","ama":"Hainzl C, Seiringer R. Mass renormalization and energy level shift in non-relativistic QED. <i>Advances in Theoretical and Mathematical Physics</i>. 2002;6(5):847-871. doi:<a href=\"https://doi.org/10.4310/ATMP.2002.v6.n5.a3\">10.4310/ATMP.2002.v6.n5.a3</a>","chicago":"Hainzl, Christian, and Robert Seiringer. “Mass Renormalization and Energy Level Shift in Non-Relativistic QED.” <i>Advances in Theoretical and Mathematical Physics</i>. International Press, 2002. <a href=\"https://doi.org/10.4310/ATMP.2002.v6.n5.a3\">https://doi.org/10.4310/ATMP.2002.v6.n5.a3</a>.","ieee":"C. Hainzl and R. Seiringer, “Mass renormalization and energy level shift in non-relativistic QED,” <i>Advances in Theoretical and Mathematical Physics</i>, vol. 6, no. 5. International Press, pp. 847–871, 2002."},"scopus_import":"1","issue":"5","main_file_link":[{"url":"http://arxiv.org/abs/math-ph/0205044","open_access":"1"}],"publication":"Advances in Theoretical and Mathematical Physics","title":"Mass renormalization and energy level shift in non-relativistic QED","external_id":{"arxiv":["math-ph/0205044v3"]},"date_updated":"2023-07-26T08:29:28Z","status":"public","day":"01","page":"847 - 871","publication_status":"published","oa_version":"Published Version","abstract":[{"lang":"eng","text":"Using the Pauli-Fierz model of non-relativistic quantum electrodynamics, we calculate the binding energy of an electron in the field of a nucleus of charge Z and in presence of the quantized radiation field. We consider the case of small coupling constant α, but fixed Zα and ultraviolet cut-off Λ. We prove that after renormalizing the mass the binding energy has, to leading order in α, a finite limit as Λ goes to infinity; i.e., the cut-off can be removed. The expression for the ground state energy shift thus obtained agrees with Bethe's formula for small values of Zα, but shows a different behavior for bigger values."}],"date_created":"2018-12-11T11:57:09Z","acknowledgement":"We are grateful to Elliott Lieb for helpful discussions. C.H. was supported by a Marie Curie Fellowship of the European Community programme “Improving Human Research Potential and the Socioeconomic Knowledge Base” under contract number HPMFCT-2000-00660 and by the Deutsche Forschungsgemeinschaft, and acknowledges kind hospitality at Princeton University, where part of this work was done. R.S. was supported by the Austrian Science Fund in the form of an Erwin Schrödinger Fellowship.\r\n","article_processing_charge":"No","extern":"1","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","intvolume":"         6","month":"09","publist_id":"4574","publication_identifier":{"issn":["1095-0761"]},"quality_controlled":"1","volume":6,"article_type":"original","doi":"10.4310/ATMP.2002.v6.n5.a3","language":[{"iso":"eng"}],"year":"2002","publisher":"International Press","type":"journal_article","author":[{"full_name":"Hainzl, Christian","first_name":"Christian","last_name":"Hainzl"},{"orcid":"0000-0002-6781-0521","last_name":"Seiringer","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","first_name":"Robert","full_name":"Seiringer, Robert"}],"_id":"2350","oa":1,"date_published":"2002-09-01T00:00:00Z"},{"intvolume":"       229","issue":"3","extern":1,"citation":{"apa":"Seiringer, R. (2002). Gross-Pitaevskii theory of the rotating Bose gas. <i>Communications in Mathematical Physics</i>. Springer. <a href=\"https://doi.org/10.1007/s00220-002-0695-2\">https://doi.org/10.1007/s00220-002-0695-2</a>","ista":"Seiringer R. 2002. Gross-Pitaevskii theory of the rotating Bose gas. Communications in Mathematical Physics. 229(3), 491–509.","short":"R. Seiringer, Communications in Mathematical Physics 229 (2002) 491–509.","mla":"Seiringer, Robert. “Gross-Pitaevskii Theory of the Rotating Bose Gas.” <i>Communications in Mathematical Physics</i>, vol. 229, no. 3, Springer, 2002, pp. 491–509, doi:<a href=\"https://doi.org/10.1007/s00220-002-0695-2\">10.1007/s00220-002-0695-2</a>.","ama":"Seiringer R. Gross-Pitaevskii theory of the rotating Bose gas. <i>Communications in Mathematical Physics</i>. 2002;229(3):491-509. doi:<a href=\"https://doi.org/10.1007/s00220-002-0695-2\">10.1007/s00220-002-0695-2</a>","chicago":"Seiringer, Robert. “Gross-Pitaevskii Theory of the Rotating Bose Gas.” <i>Communications in Mathematical Physics</i>. Springer, 2002. <a href=\"https://doi.org/10.1007/s00220-002-0695-2\">https://doi.org/10.1007/s00220-002-0695-2</a>.","ieee":"R. Seiringer, “Gross-Pitaevskii theory of the rotating Bose gas,” <i>Communications in Mathematical Physics</i>, vol. 229, no. 3. Springer, pp. 491–509, 2002."},"date_created":"2018-12-11T11:57:09Z","title":"Gross-Pitaevskii theory of the rotating Bose gas","volume":229,"publication":"Communications in Mathematical Physics","main_file_link":[{"url":"http://arxiv.org/abs/math-ph/0110010","open_access":"1"}],"publist_id":"4575","quality_controlled":0,"month":"09","type":"journal_article","status":"public","year":"2002","date_updated":"2021-01-12T06:56:57Z","publisher":"Springer","doi":"10.1007/s00220-002-0695-2","abstract":[{"text":"We study the Gross-Pitaevskii functional for a rotating two-dimensional Bose gas in a trap. We prove that there is a breaking of the rotational symmetry in the ground state; more precisely, for any value of the angular velocity and for large enough values of the interaction strength, the ground state of the functional is not an eigenfunction of the angular momentum. This has interesting consequences on the Bose gas with spin; in particular, the ground state energy depends non-trivially on the number of spin components, and the different components do not have the same wave function. For the special case of a harmonic trap potential, we give explicit upper and lower bounds on the critical coupling constant for symmetry breaking.","lang":"eng"}],"day":"01","page":"491 - 509","publication_status":"published","date_published":"2002-09-01T00:00:00Z","_id":"2351","oa":1,"author":[{"orcid":"0000-0002-6781-0521","last_name":"Seiringer","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","first_name":"Robert","full_name":"Robert Seiringer"}]}]