[{"extern":"1","volume":94,"acknowledgement":"This work was supported in part by grants from the 358 (1992) 36–41.Deutsche Forschungsgemeinschaft (Bi 642 / 1-2) and the Volkswagen foundation. ","external_id":{"pmid":["11597769"]},"date_updated":"2023-05-15T13:42:32Z","year":"2001","citation":{"chicago":"Jerecic, Jasna, Christian Schulze, Peter M Jonas, Rolf Sprengel, Peter Seeburg, and Joseph Bischofberger. “Impaired NMDA Receptor Function in Mouse Olfactory Bulb Neurons by Tetracycline-Sensitive NR1 (N598R) Expression.” <i>Molecular Brain Research</i>. Elsevier, 2001. <a href=\"https://doi.org/10.1016/S0169-328X(01)00221-2\">https://doi.org/10.1016/S0169-328X(01)00221-2</a>.","ieee":"J. Jerecic, C. Schulze, P. M. Jonas, R. Sprengel, P. Seeburg, and J. Bischofberger, “Impaired NMDA receptor function in mouse olfactory bulb neurons by tetracycline-sensitive NR1 (N598R) expression,” <i>Molecular Brain Research</i>, vol. 94, no. 1–2. Elsevier, pp. 96–104, 2001.","ama":"Jerecic J, Schulze C, Jonas PM, Sprengel R, Seeburg P, Bischofberger J. Impaired NMDA receptor function in mouse olfactory bulb neurons by tetracycline-sensitive NR1 (N598R) expression. <i>Molecular Brain Research</i>. 2001;94(1-2):96-104. doi:<a href=\"https://doi.org/10.1016/S0169-328X(01)00221-2\">10.1016/S0169-328X(01)00221-2</a>","apa":"Jerecic, J., Schulze, C., Jonas, P. M., Sprengel, R., Seeburg, P., &#38; Bischofberger, J. (2001). Impaired NMDA receptor function in mouse olfactory bulb neurons by tetracycline-sensitive NR1 (N598R) expression. <i>Molecular Brain Research</i>. Elsevier. <a href=\"https://doi.org/10.1016/S0169-328X(01)00221-2\">https://doi.org/10.1016/S0169-328X(01)00221-2</a>","ista":"Jerecic J, Schulze C, Jonas PM, Sprengel R, Seeburg P, Bischofberger J. 2001. Impaired NMDA receptor function in mouse olfactory bulb neurons by tetracycline-sensitive NR1 (N598R) expression. Molecular Brain Research. 94(1–2), 96–104.","mla":"Jerecic, Jasna, et al. “Impaired NMDA Receptor Function in Mouse Olfactory Bulb Neurons by Tetracycline-Sensitive NR1 (N598R) Expression.” <i>Molecular Brain Research</i>, vol. 94, no. 1–2, Elsevier, 2001, pp. 96–104, doi:<a href=\"https://doi.org/10.1016/S0169-328X(01)00221-2\">10.1016/S0169-328X(01)00221-2</a>.","short":"J. Jerecic, C. Schulze, P.M. Jonas, R. Sprengel, P. Seeburg, J. Bischofberger, Molecular Brain Research 94 (2001) 96–104."},"abstract":[{"lang":"eng","text":"High Ca2+ permeability and its control by voltage-dependent Mg2+ block are defining features of NMDA receptors. These features are lost if the principal NR1 subunit carries an asparagine (N) to arginine (R) substitution in a critical channel site at NR1 position 598. NR1(R) expression from a single allele in gene-targeted NR1+/R mice is lethal soon after birth, precluding analysis of altered synaptic functions later in life. We therefore employed the forebrain specific αCaMKII promoter to drive tTA-mediated tetracyclin sensitive transcription of transgenes for NR1(R) and for lacZ as reporter. Transgene expression was observed in cortex, striatum, hippocampus, amygdala and olfactory bulb and was mosaic in all these forebrain regions. It was highest in olfactory bulb granule cells, in most of which Ca2+ permeability and voltage-dependent Mg2+ block of NMDA receptors were reduced to different extents. This indicates significant impairment of NMDA receptor function by NR1(R) in presence of the wild-type NR1 complement. Indeed, even though NR1(R) mRNA constituted only 18% of the entire NR1 mRNA population in forebrain, the transgenic mice died during adolescence unless transgene expression was suppressed by doxycycline. Thus, glutamate receptor function can be altered in the mouse by regulated NR1(R) transgene expression."}],"doi":"10.1016/S0169-328X(01)00221-2","day":"19","page":"96 - 104","quality_controlled":"1","article_type":"original","publisher":"Elsevier","author":[{"last_name":"Jerecic","first_name":"Jasna","full_name":"Jerecic, Jasna"},{"full_name":"Schulze, Christian","last_name":"Schulze","first_name":"Christian"},{"id":"353C1B58-F248-11E8-B48F-1D18A9856A87","first_name":"Peter M","last_name":"Jonas","orcid":"0000-0001-5001-4804","full_name":"Jonas, Peter M"},{"full_name":"Sprengel, Rolf","last_name":"Sprengel","first_name":"Rolf"},{"full_name":"Seeburg, Peter","first_name":"Peter","last_name":"Seeburg"},{"last_name":"Bischofberger","first_name":"Joseph","full_name":"Bischofberger, Joseph"}],"issue":"1-2","pmid":1,"_id":"3495","scopus_import":"1","title":"Impaired NMDA receptor function in mouse olfactory bulb neurons by tetracycline-sensitive NR1 (N598R) expression","intvolume":"        94","publication_status":"published","article_processing_charge":"No","date_created":"2018-12-11T12:03:38Z","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","status":"public","date_published":"2001-10-19T00:00:00Z","type":"journal_article","publist_id":"2892","publication_identifier":{"issn":["0169-328X"]},"language":[{"iso":"eng"}],"publication":"Molecular Brain Research","month":"10","oa_version":"None"},{"issue":"25","author":[{"last_name":"Alle","first_name":"Henrik","full_name":"Alle, Henrik"},{"orcid":"0000-0001-5001-4804","full_name":"Jonas, Peter M","first_name":"Peter M","last_name":"Jonas","id":"353C1B58-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Jörg","last_name":"Geiger","full_name":"Geiger, Jörg"}],"scopus_import":"1","_id":"3496","pmid":1,"intvolume":"        98","title":"PTP and LTP at a hippocampal mossy fiber-interneuron synapse","date_created":"2018-12-11T12:03:38Z","article_processing_charge":"No","publication_status":"published","quality_controlled":"1","page":"14708 - 14713","article_type":"original","publisher":"National Academy of Sciences","external_id":{"pmid":["11734656"]},"year":"2001","citation":{"ieee":"H. Alle, P. M. Jonas, and J. Geiger, “PTP and LTP at a hippocampal mossy fiber-interneuron synapse,” <i>PNAS</i>, vol. 98, no. 25. National Academy of Sciences, pp. 14708–14713, 2001.","chicago":"Alle, Henrik, Peter M Jonas, and Jörg Geiger. “PTP and LTP at a Hippocampal Mossy Fiber-Interneuron Synapse.” <i>PNAS</i>. National Academy of Sciences, 2001. <a href=\"https://doi.org/10.1073/pnas.251610898 \">https://doi.org/10.1073/pnas.251610898 </a>.","ama":"Alle H, Jonas PM, Geiger J. PTP and LTP at a hippocampal mossy fiber-interneuron synapse. <i>PNAS</i>. 2001;98(25):14708-14713. doi:<a href=\"https://doi.org/10.1073/pnas.251610898 \">10.1073/pnas.251610898 </a>","apa":"Alle, H., Jonas, P. M., &#38; Geiger, J. (2001). PTP and LTP at a hippocampal mossy fiber-interneuron synapse. <i>PNAS</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.251610898 \">https://doi.org/10.1073/pnas.251610898 </a>","ista":"Alle H, Jonas PM, Geiger J. 2001. PTP and LTP at a hippocampal mossy fiber-interneuron synapse. PNAS. 98(25), 14708–14713.","short":"H. Alle, P.M. Jonas, J. Geiger, PNAS 98 (2001) 14708–14713.","mla":"Alle, Henrik, et al. “PTP and LTP at a Hippocampal Mossy Fiber-Interneuron Synapse.” <i>PNAS</i>, vol. 98, no. 25, National Academy of Sciences, 2001, pp. 14708–13, doi:<a href=\"https://doi.org/10.1073/pnas.251610898 \">10.1073/pnas.251610898 </a>."},"date_updated":"2023-05-15T11:08:08Z","abstract":[{"lang":"eng","text":"The mossy fiber-CA3 pyramidal neuron synapse is a main component of the hippocampal trisynaptic circuitry. Recent studies, however, suggested that inhibitory interneurons are the major targets of the mossy fiber system. To study the regulation of mossy fiber-interneuron excitation, we examined unitary and compound excitatory postsynaptic currents in dentate gyrus basket cells, evoked by paired recording between granule and basket cells or extracellular stimulation of mossy fiber collaterals. The application of an associative high-frequency stimulation paradigm induced posttetanic potentiation (PTP) followed by homosynaptic long-term potentiation (LTP). Analysis of numbers of failures, coefficient of variation, and paired-pulse modulation indicated that both PTP and LTP were expressed presynaptically. The Ca2+ chelator 1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid (BAPTA) did not affect PTP or LTP at a concentration of 10 mM but attenuated LTP at a concentration of 30 mM. Both forskolin, an adenylyl cyclase activator, and phorbolester diacetate, a protein kinase C stimulator, lead to a long-lasting increase in excitatory postsynaptic current amplitude. H-89, a protein kinase A inhibitor, and bisindolylmaleimide, a protein kinase C antagonist, reduced PTP, whereas only bisindolylmaleimide reduced LTP. These results may suggest a differential contribution of protein kinase A and C pathways to mossy fiber-interneuron plasticity. Interneuron PTP and LTP may provide mechanisms to maintain the balance between synaptic excitation of interneurons and that of principal neurons in the dentate gyrus-CA3 network. "}],"day":"04","doi":"10.1073/pnas.251610898 ","extern":"1","acknowledgement":"We thank Drs. J. Bischofberger and M. Martina for critically reading an earlier version of the manuscript and A. Blomenkamp for excellent technical assistance. Supported by the Deutsche Forschungsgemeinschaft Sonderforschungsbereich 505/C5 and Human Frontiers Science Program Organization Grant RG0017/98.","volume":98,"publication":"PNAS","month":"12","oa_version":"None","language":[{"iso":"eng"}],"type":"journal_article","date_published":"2001-12-04T00:00:00Z","publist_id":"2891","oa":1,"publication_identifier":{"issn":["0027-8424"]},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","status":"public","main_file_link":[{"url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC64746/","open_access":"1"}]},{"date_updated":"2022-01-05T15:12:42Z","citation":{"ista":"Liang J, Edelsbrunner H. 2001. Molecular classification for property prediction.","mla":"Liang, Jie, and Herbert Edelsbrunner. <i>Molecular Classification for Property Prediction</i>. 2001.","short":"J. Liang, H. Edelsbrunner, (2001).","chicago":"Liang, Jie, and Herbert Edelsbrunner. “Molecular Classification for Property Prediction,” 2001.","ieee":"J. Liang and H. Edelsbrunner, “Molecular classification for property prediction.” 2001.","apa":"Liang, J., &#38; Edelsbrunner, H. (2001). Molecular classification for property prediction.","ama":"Liang J, Edelsbrunner H. Molecular classification for property prediction. 2001."},"year":"2001","date_published":"2001-01-30T00:00:00Z","type":"patent","publication_date":"2001-01-30","day":"30","abstract":[{"text":"A molecular classification method is based on a space filling description of a molecule. The three dimensional body corresponding to the space filling molecular structure is divided into Voronoi regions to provide a basis for efficiently processing local structural information. A Delaunay triangulation provides a basis for systematically processing information relating to the Voronoi regions into shape descriptors in the form of topological elements. Preferably, additional shape and/or property descriptors are included in the classification method. The classification methods generally are used to identify similarities between molecules that can be used as property predictors for a variety of applications. Generally, the property predictions are the basis for selection of compounds for incorporation into efficacy evaluations.","lang":"eng"}],"oa":1,"publist_id":"2880","main_file_link":[{"open_access":"1","url":"https://patents.google.com/patent/US6182016B1"}],"extern":"1","status":"public","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","_id":"3507","author":[{"full_name":"Liang, Jie","last_name":"Liang","first_name":"Jie"},{"id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","first_name":"Herbert","last_name":"Edelsbrunner","orcid":"0000-0002-9823-6833","full_name":"Edelsbrunner, Herbert"}],"oa_version":"Published Version","article_processing_charge":"No","date_created":"2018-12-11T12:03:41Z","ipc":"G16C20/70 ; G16B15/00","applicant":["Jie Liang, Herbert Edelsbrunner"],"month":"01","title":"Molecular classification for property prediction","ipn":"US6182016B1"},{"doi":"10.1016/S0165-0270(00)00362-9","day":"30","abstract":[{"text":"A modular multichannel microdrive ('hyperdrive') is described. The microdrive uses printed circuit board technology and flexible fused silica capillaries. The modular design allows for the fabrication of 4-32 independently movable electrodes or `tetrodes'. The drives are re-usable and re-loading the drive with electrodes is simple. ","lang":"eng"}],"date_updated":"2023-05-15T10:50:39Z","citation":{"ista":"Szabo I, Czurkó A, Csicsvari JL, Hirase H, Leinekugel X, Buzsáki G. 2001. The application of printed circuit board technology for fabrication of multi-channel micro-drives. Journal of Neuroscience Methods. 105(1), 105–110.","short":"I. Szabo, A. Czurkó, J.L. Csicsvari, H. Hirase, X. Leinekugel, G. Buzsáki, Journal of Neuroscience Methods 105 (2001) 105–110.","mla":"Szabo, Imre, et al. “The Application of Printed Circuit Board Technology for Fabrication of Multi-Channel Micro-Drives.” <i>Journal of Neuroscience Methods</i>, vol. 105, no. 1, Elsevier, 2001, pp. 105–10, doi:<a href=\"https://doi.org/10.1016/S0165-0270(00)00362-9\">10.1016/S0165-0270(00)00362-9</a>.","chicago":"Szabo, Imre, András Czurkó, Jozsef L Csicsvari, Hajima Hirase, Xavier Leinekugel, and György Buzsáki. “The Application of Printed Circuit Board Technology for Fabrication of Multi-Channel Micro-Drives.” <i>Journal of Neuroscience Methods</i>. Elsevier, 2001. <a href=\"https://doi.org/10.1016/S0165-0270(00)00362-9\">https://doi.org/10.1016/S0165-0270(00)00362-9</a>.","ieee":"I. Szabo, A. Czurkó, J. L. Csicsvari, H. Hirase, X. Leinekugel, and G. Buzsáki, “The application of printed circuit board technology for fabrication of multi-channel micro-drives,” <i>Journal of Neuroscience Methods</i>, vol. 105, no. 1. Elsevier, pp. 105–110, 2001.","apa":"Szabo, I., Czurkó, A., Csicsvari, J. L., Hirase, H., Leinekugel, X., &#38; Buzsáki, G. (2001). The application of printed circuit board technology for fabrication of multi-channel micro-drives. <i>Journal of Neuroscience Methods</i>. Elsevier. <a href=\"https://doi.org/10.1016/S0165-0270(00)00362-9\">https://doi.org/10.1016/S0165-0270(00)00362-9</a>","ama":"Szabo I, Czurkó A, Csicsvari JL, Hirase H, Leinekugel X, Buzsáki G. The application of printed circuit board technology for fabrication of multi-channel micro-drives. <i>Journal of Neuroscience Methods</i>. 2001;105(1):105-110. doi:<a href=\"https://doi.org/10.1016/S0165-0270(00)00362-9\">10.1016/S0165-0270(00)00362-9</a>"},"year":"2001","external_id":{"pmid":["11166371"]},"volume":105,"extern":"1","publication_status":"published","article_processing_charge":"No","date_created":"2018-12-11T12:03:45Z","title":"The application of printed circuit board technology for fabrication of multi-channel micro-drives","intvolume":"       105","pmid":1,"_id":"3517","scopus_import":"1","author":[{"full_name":"Szabo, Imre","last_name":"Szabo","first_name":"Imre"},{"last_name":"Czurkó","first_name":"András","full_name":"Czurkó, András"},{"orcid":"0000-0002-5193-4036","full_name":"Csicsvari, Jozsef L","first_name":"Jozsef L","last_name":"Csicsvari","id":"3FA14672-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Hajima","last_name":"Hirase","full_name":"Hirase, Hajima"},{"first_name":"Xavier","last_name":"Leinekugel","full_name":"Leinekugel, Xavier"},{"full_name":"Buzsáki, György","last_name":"Buzsáki","first_name":"György"}],"issue":"1","publisher":"Elsevier","article_type":"original","page":"105 - 110","quality_controlled":"1","publication_identifier":{"issn":["0165-0270"]},"publist_id":"2868","date_published":"2001-01-30T00:00:00Z","type":"journal_article","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","status":"public","oa_version":"None","month":"01","publication":"Journal of Neuroscience Methods","language":[{"iso":"eng"}]},{"language":[{"iso":"eng"}],"month":"07","oa_version":"Published Version","publication":"PNAS","status":"public","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC55430/"}],"publist_id":"2846","oa":1,"publication_identifier":{"issn":["0027-8424"]},"date_published":"2001-07-31T00:00:00Z","type":"journal_article","article_type":"original","publisher":"National Academy of Sciences","page":"9386 - 9390","quality_controlled":"1","title":"Firing rates of hippocampal neurons are preserved during subsequent sleep episodes and modified by novel awake experience","intvolume":"        98","publication_status":"published","article_processing_charge":"No","date_created":"2018-12-11T12:03:52Z","author":[{"last_name":"Hirase","first_name":"Hajima","full_name":"Hirase, Hajima"},{"first_name":"Xavier","last_name":"Leinekugel","full_name":"Leinekugel, Xavier"},{"full_name":"Czurkó, András","last_name":"Czurkó","first_name":"András"},{"full_name":"Csicsvari, Jozsef L","orcid":"0000-0002-5193-4036","last_name":"Csicsvari","first_name":"Jozsef L","id":"3FA14672-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Buzsáki, György","first_name":"György","last_name":"Buzsáki"}],"issue":"16","_id":"3540","pmid":1,"scopus_import":"1","extern":"1","volume":98,"acknowledgement":"This work was supported by National Institutes of Health Grants NS34994 and MH54671, the F. M. Kirby Foundation, the Human Frontier Science Program (X.L.), and the Uehara Memorial Foundation (H.H.).","abstract":[{"lang":"eng","text":"What determines the firing rate of cortical neurons in the absence of external sensory input or motor behavior, such as during sleep? Hero we report that, in a familiar environment, the discharge frequency of simultaneously recorded individual CA1 pyramidal neurons and the coactivation of cell pairs remain highly correlated across sleep-wake-steep sequences. However, both measures were affected when new sets of neurons were activated in a novel environment. Nevertheless, the grand mean firing rate of the whole pyramidal cell population remained constant across behavioral states and testing conditions. The findings suggest that long-term firing patterns of single cells can be modified by experience. We hypothesize that increased firing rates of recently used neurons are associated with a concomitant decrease in the discharge activity of the remaining population, leaving the mean excitability of the hippocampal network unaltered."}],"doi":"10.1073/pnas.161274398","day":"31","external_id":{"pmid":["11470910"]},"date_updated":"2023-05-12T10:07:41Z","citation":{"ieee":"H. Hirase, X. Leinekugel, A. Czurkó, J. L. Csicsvari, and G. Buzsáki, “Firing rates of hippocampal neurons are preserved during subsequent sleep episodes and modified by novel awake experience,” <i>PNAS</i>, vol. 98, no. 16. National Academy of Sciences, pp. 9386–9390, 2001.","chicago":"Hirase, Hajima, Xavier Leinekugel, András Czurkó, Jozsef L Csicsvari, and György Buzsáki. “Firing Rates of Hippocampal Neurons Are Preserved during Subsequent Sleep Episodes and Modified by Novel Awake Experience.” <i>PNAS</i>. National Academy of Sciences, 2001. <a href=\"https://doi.org/10.1073/pnas.161274398\">https://doi.org/10.1073/pnas.161274398</a>.","apa":"Hirase, H., Leinekugel, X., Czurkó, A., Csicsvari, J. L., &#38; Buzsáki, G. (2001). Firing rates of hippocampal neurons are preserved during subsequent sleep episodes and modified by novel awake experience. <i>PNAS</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.161274398\">https://doi.org/10.1073/pnas.161274398</a>","ama":"Hirase H, Leinekugel X, Czurkó A, Csicsvari JL, Buzsáki G. Firing rates of hippocampal neurons are preserved during subsequent sleep episodes and modified by novel awake experience. <i>PNAS</i>. 2001;98(16):9386-9390. doi:<a href=\"https://doi.org/10.1073/pnas.161274398\">10.1073/pnas.161274398</a>","ista":"Hirase H, Leinekugel X, Czurkó A, Csicsvari JL, Buzsáki G. 2001. Firing rates of hippocampal neurons are preserved during subsequent sleep episodes and modified by novel awake experience. PNAS. 98(16), 9386–9390.","short":"H. Hirase, X. Leinekugel, A. Czurkó, J.L. Csicsvari, G. Buzsáki, PNAS 98 (2001) 9386–9390.","mla":"Hirase, Hajima, et al. “Firing Rates of Hippocampal Neurons Are Preserved during Subsequent Sleep Episodes and Modified by Novel Awake Experience.” <i>PNAS</i>, vol. 98, no. 16, National Academy of Sciences, 2001, pp. 9386–90, doi:<a href=\"https://doi.org/10.1073/pnas.161274398\">10.1073/pnas.161274398</a>."},"year":"2001"},{"publication_identifier":{"issn":["0270-6474"]},"oa":1,"publist_id":"2839","type":"journal_article","date_published":"2001-05-15T00:00:00Z","main_file_link":[{"open_access":"1","url":"https://pubmed.ncbi.nlm.nih.gov/11319243/"}],"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","status":"public","oa_version":"Published Version","month":"05","publication":"Journal of Neuroscience","language":[{"iso":"eng"}],"day":"15","doi":"10.1523/JNEUROSCI.21-10-j0003.2001","abstract":[{"text":"Local versus distant coherence of hippocampal CA1 pyramidal cells was investigated in the behaving rat. Temporal cross-correlation of pyramidal cells revealed a significantly stronger relationship among local (&lt;140 &lt;mu&gt;m) pyramidal neurons compared with distant (&gt;300 mum) neurons during non-theta-associated immobility and sleep but not during theta-associated running and walking. In contrast, cross-correlation between local pyramidal cell-interneuron pairs was significantly stronger than between distant pairs during theta oscillations but were similar during non-theta-associated behaviors. We suggest that network state-dependent functional clustering of neuronal activity emerges because of the differential contribution of the main excitatory inputs, the perforant path, and Schaffer collaterals during theta and non-theta behaviors.","lang":"eng"}],"year":"2001","citation":{"chicago":"Hirase, Hajima, Xavier Leinekugel, Jozsef L Csicsvari, András Czurkó, and György Buzsáki. “Behavior-Dependent States of the Hippocampal Network Affect Functional Clustering of Neurons.” <i>Journal of Neuroscience</i>. Society for Neuroscience, 2001. <a href=\"https://doi.org/10.1523/JNEUROSCI.21-10-j0003.2001\">https://doi.org/10.1523/JNEUROSCI.21-10-j0003.2001</a>.","ieee":"H. Hirase, X. Leinekugel, J. L. Csicsvari, A. Czurkó, and G. Buzsáki, “Behavior-dependent states of the hippocampal network affect functional clustering of neurons,” <i>Journal of Neuroscience</i>, vol. 21, no. 10. Society for Neuroscience, 2001.","ama":"Hirase H, Leinekugel X, Csicsvari JL, Czurkó A, Buzsáki G. Behavior-dependent states of the hippocampal network affect functional clustering of neurons. <i>Journal of Neuroscience</i>. 2001;21(10). doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.21-10-j0003.2001\">10.1523/JNEUROSCI.21-10-j0003.2001</a>","apa":"Hirase, H., Leinekugel, X., Csicsvari, J. L., Czurkó, A., &#38; Buzsáki, G. (2001). Behavior-dependent states of the hippocampal network affect functional clustering of neurons. <i>Journal of Neuroscience</i>. Society for Neuroscience. <a href=\"https://doi.org/10.1523/JNEUROSCI.21-10-j0003.2001\">https://doi.org/10.1523/JNEUROSCI.21-10-j0003.2001</a>","ista":"Hirase H, Leinekugel X, Csicsvari JL, Czurkó A, Buzsáki G. 2001. Behavior-dependent states of the hippocampal network affect functional clustering of neurons. Journal of Neuroscience. 21(10).","short":"H. Hirase, X. Leinekugel, J.L. Csicsvari, A. Czurkó, G. Buzsáki, Journal of Neuroscience 21 (2001).","mla":"Hirase, Hajima, et al. “Behavior-Dependent States of the Hippocampal Network Affect Functional Clustering of Neurons.” <i>Journal of Neuroscience</i>, vol. 21, no. 10, Society for Neuroscience, 2001, doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.21-10-j0003.2001\">10.1523/JNEUROSCI.21-10-j0003.2001</a>."},"date_updated":"2023-05-12T09:47:39Z","external_id":{"pmid":["11319243"]},"volume":21,"extern":"1","article_processing_charge":"No","date_created":"2018-12-11T12:03:54Z","publication_status":"published","intvolume":"        21","title":"Behavior-dependent states of the hippocampal network affect functional clustering of neurons","scopus_import":"1","pmid":1,"_id":"3546","issue":"10","author":[{"full_name":"Hirase, Hajima","first_name":"Hajima","last_name":"Hirase"},{"first_name":"Xavier","last_name":"Leinekugel","full_name":"Leinekugel, Xavier"},{"id":"3FA14672-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-5193-4036","full_name":"Csicsvari, Jozsef L","first_name":"Jozsef L","last_name":"Csicsvari"},{"first_name":"András","last_name":"Czurkó","full_name":"Czurkó, András"},{"first_name":"György","last_name":"Buzsáki","full_name":"Buzsáki, György"}],"publisher":"Society for Neuroscience","article_type":"original","quality_controlled":"1"},{"oa_version":"None","publication_status":"published","article_processing_charge":"No","date_created":"2018-12-11T12:04:06Z","title":"Geometry and Topology for Mesh Generation","month":"05","intvolume":"         7","_id":"3586","author":[{"full_name":"Edelsbrunner, Herbert","orcid":"0000-0002-9823-6833","last_name":"Edelsbrunner","first_name":"Herbert","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87"}],"publisher":"Cambridge University Press","page":"190","series_title":"Cambridge Monographs on Applied and Computational Mathematics","quality_controlled":"1","language":[{"iso":"eng"}],"doi":"10.1017/CBO9780511530067","publication_identifier":{"eisbn":[" 978-0-5115-3006-7"],"isbn":["0-521-79309-2"]},"day":"28","abstract":[{"lang":"eng","text":"The book combines topics in mathematics (geometry and topology), computer science (algorithms), and engineering (mesh generation). The original motivation for these topics was the difficulty faced (both conceptually and in the technical execution) in any attempt to combine elements of combinatorial and of numerical algorithms. Mesh generation is a topic where a meaningful combination of these different approaches to problem solving is inevitable. The book develops methods from both areas that are amenable to combination, and explains recent breakthrough solutions to meshing that fit into this category.The book should be an ideal graduate text for courses on mesh generation. The specific material is selected giving preference to topics that are elementary, attractive, lend themselves to teaching, useful, and interesting."}],"publist_id":"2798","date_updated":"2021-12-22T08:46:46Z","year":"2001","citation":{"ama":"Edelsbrunner H. <i>Geometry and Topology for Mesh Generation</i>. Vol 7. Cambridge University Press; 2001. doi:<a href=\"https://doi.org/10.1017/CBO9780511530067\">10.1017/CBO9780511530067</a>","apa":"Edelsbrunner, H. (2001). <i>Geometry and Topology for Mesh Generation</i> (Vol. 7). Cambridge University Press. <a href=\"https://doi.org/10.1017/CBO9780511530067\">https://doi.org/10.1017/CBO9780511530067</a>","ieee":"H. Edelsbrunner, <i>Geometry and Topology for Mesh Generation</i>, vol. 7. Cambridge University Press, 2001.","chicago":"Edelsbrunner, Herbert. <i>Geometry and Topology for Mesh Generation</i>. Vol. 7. Cambridge Monographs on Applied and Computational Mathematics. Cambridge University Press, 2001. <a href=\"https://doi.org/10.1017/CBO9780511530067\">https://doi.org/10.1017/CBO9780511530067</a>.","short":"H. Edelsbrunner, Geometry and Topology for Mesh Generation, Cambridge University Press, 2001.","mla":"Edelsbrunner, Herbert. <i>Geometry and Topology for Mesh Generation</i>. Vol. 7, Cambridge University Press, 2001, doi:<a href=\"https://doi.org/10.1017/CBO9780511530067\">10.1017/CBO9780511530067</a>.","ista":"Edelsbrunner H. 2001. Geometry and Topology for Mesh Generation, Cambridge University Press, 190p."},"date_published":"2001-05-28T00:00:00Z","type":"book","volume":7,"extern":"1","related_material":{"link":[{"url":"https://koha.app.ist.ac.at/cgi-bin/koha/opac-detail.pl?biblionumber=3508","description":"available via catalog IST BookList","relation":"other"}]},"status":"public","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9"},{"status":"public","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","extern":"1","volume":17,"type":"review","date_published":"2001-07-01T00:00:00Z","citation":{"short":"N.H. Barton, Trends in Genetics 17 (2001) 420–420.","mla":"Barton, Nicholas H. “Mendel and Mathematics.” <i>Trends in Genetics</i>, vol. 17, Elsevier, 2001, pp. 420–420, doi:<a href=\"https://doi.org/10.1016/S0168-9525(01)02315-0\">10.1016/S0168-9525(01)02315-0</a>.","ista":"Barton NH. 2001. Mendel and mathematics. Trends in Genetics. 17, 420–420.","apa":"Barton, N. H. (2001). Mendel and mathematics. <i>Trends in Genetics</i>. Elsevier. <a href=\"https://doi.org/10.1016/S0168-9525(01)02315-0\">https://doi.org/10.1016/S0168-9525(01)02315-0</a>","ama":"Barton NH. Mendel and mathematics. <i>Trends in Genetics</i>. 2001;17:420-420. doi:<a href=\"https://doi.org/10.1016/S0168-9525(01)02315-0\">10.1016/S0168-9525(01)02315-0</a>","chicago":"Barton, Nicholas H. “Mendel and Mathematics.” <i>Trends in Genetics</i>. Elsevier, 2001. <a href=\"https://doi.org/10.1016/S0168-9525(01)02315-0\">https://doi.org/10.1016/S0168-9525(01)02315-0</a>.","ieee":"N. H. Barton, “Mendel and mathematics,” <i>Trends in Genetics</i>, vol. 17. Elsevier, pp. 420–420, 2001."},"year":"2001","date_updated":"2023-05-11T13:50:32Z","publist_id":"2787","day":"01","publication_identifier":{"issn":["0168-9479"]},"doi":"10.1016/S0168-9525(01)02315-0","language":[{"iso":"eng"}],"quality_controlled":"1","page":"420 - 420","publisher":"Elsevier","author":[{"last_name":"Barton","first_name":"Nicholas H","full_name":"Barton, Nicholas H","orcid":"0000-0002-8548-5240","id":"4880FE40-F248-11E8-B48F-1D18A9856A87"}],"publication":"Trends in Genetics","_id":"3596","intvolume":"        17","title":"Mendel and mathematics","month":"07","article_processing_charge":"No","date_created":"2018-12-11T12:04:09Z","publication_status":"published","oa_version":"None"},{"volume":55,"acknowledgement":"We thank SERC and BBSRC for financial support and R.Miah, G. Geddes, and E. Garcia for technical assistance.","extern":"1","date_updated":"2023-05-11T13:43:30Z","citation":{"apa":"Gardner, M., Fowler, K., Patridge, L., &#38; Barton, N. H. (2001). Genetic variation for preadult viability in Drosophila melanogaster. <i>Evolution</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1111/j.0014-3820.2001.tb00680.x\">https://doi.org/10.1111/j.0014-3820.2001.tb00680.x</a>","ama":"Gardner M, Fowler K, Patridge L, Barton NH. Genetic variation for preadult viability in Drosophila melanogaster. <i>Evolution</i>. 2001;55(8):1609-1620. doi:<a href=\"https://doi.org/10.1111/j.0014-3820.2001.tb00680.x\">10.1111/j.0014-3820.2001.tb00680.x</a>","ieee":"M. Gardner, K. Fowler, L. Patridge, and N. H. Barton, “Genetic variation for preadult viability in Drosophila melanogaster,” <i>Evolution</i>, vol. 55, no. 8. Wiley-Blackwell, pp. 1609–1620, 2001.","chicago":"Gardner, Michael, Kevin Fowler, Linda Patridge, and Nicholas H Barton. “Genetic Variation for Preadult Viability in Drosophila Melanogaster.” <i>Evolution</i>. Wiley-Blackwell, 2001. <a href=\"https://doi.org/10.1111/j.0014-3820.2001.tb00680.x\">https://doi.org/10.1111/j.0014-3820.2001.tb00680.x</a>.","mla":"Gardner, Michael, et al. “Genetic Variation for Preadult Viability in Drosophila Melanogaster.” <i>Evolution</i>, vol. 55, no. 8, Wiley-Blackwell, 2001, pp. 1609–20, doi:<a href=\"https://doi.org/10.1111/j.0014-3820.2001.tb00680.x\">10.1111/j.0014-3820.2001.tb00680.x</a>.","short":"M. Gardner, K. Fowler, L. Patridge, N.H. Barton, Evolution 55 (2001) 1609–1620.","ista":"Gardner M, Fowler K, Patridge L, Barton NH. 2001. Genetic variation for preadult viability in Drosophila melanogaster. Evolution. 55(8), 1609–1620."},"year":"2001","external_id":{"pmid":["11580020"]},"doi":"10.1111/j.0014-3820.2001.tb00680.x","day":"01","abstract":[{"lang":"eng","text":"The extent of genetic variation in fitness and its components and genetic variation's dependence on environmental conditions remain key issues in evolutionary biology. We present measurements of genetic variation in preadult viability in a laboratory-adapted population of Drosophila melanogaster, made at four different densities. By crossing flies heterozygous for a wild-type chromosome and one of two different balancers (TM1, TM2), we measure both heterozygous (TM1/+, TM2/+) and homozygous (+/+) viability relative to a standard genotype (TM1/TM2). Forty wild-type chromosomes were tested, of which 10 were chosen to be homozygous viable. The mean numbers produced varied significantly between chromosome lines, with an estimated between-line variance in loge numbers of 0.013. Relative viabilities also varied significantly across chromosome lines, with a variance in loge homozygous viability of 1.76 and of loge heterozygous viability of 0.165. The between-line variance for numbers emerging increased with density, from 0.009 at lowest density to 0.079 at highest. The genetic variance in relative viability increases with density, but not significantly. Overall, the effects of different chromosomes on relative viability were remarkably consistent across densities and across the two heterozygous genotypes (TM1, TM2). The 10 lines that carried homozygous viable wild-type chromosomes produced significantly more adults than the 30 lethal lines at low density and significantly fewer adults at the highest density. Similarly, there was a positive correlation between heterozygous viability and mean numbers at low density, but a negative correlation at high density."}],"page":"1609 - 1620","quality_controlled":"1","publisher":"Wiley-Blackwell","article_type":"original","pmid":1,"_id":"3622","scopus_import":"1","author":[{"full_name":"Gardner, Michael","first_name":"Michael","last_name":"Gardner"},{"full_name":"Fowler, Kevin","last_name":"Fowler","first_name":"Kevin"},{"full_name":"Patridge, Linda","first_name":"Linda","last_name":"Patridge"},{"first_name":"Nicholas H","last_name":"Barton","orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87"}],"issue":"8","publication_status":"published","date_created":"2018-12-11T12:04:18Z","article_processing_charge":"No","title":"Genetic variation for preadult viability in Drosophila melanogaster","intvolume":"        55","main_file_link":[{"url":"http://www.jstor.org/stable/2680379"}],"status":"public","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_published":"2001-08-01T00:00:00Z","type":"journal_article","publication_identifier":{"issn":["0014-3820"]},"publist_id":"2761","language":[{"iso":"eng"}],"publication":"Evolution","oa_version":"None","month":"08"},{"main_file_link":[{"open_access":"1","url":"http://www.jimmunol.org/content/166/2/1300.long"}],"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","status":"public","date_published":"2001-01-15T00:00:00Z","type":"journal_article","publication_identifier":{"issn":["0022-1767"]},"oa":1,"publist_id":"2200","language":[{"iso":"eng"}],"publication":"Journal of Immunology","oa_version":"None","month":"01","acknowledgement":"We thank Dr. H. Bluethmann (F. Hoffmann-LaRoche AG, Basle, Switzerland) for kindly providing us TNFR knockout mice. We are indebted to Dr. G. R. Adolf (Bender & Co Vienna, Austria) for providing recombinant murine TNF. We are also indebted to Dr. D. Vestweber for providing anti-P-selectin mAb (23). We thank Dr. W. Neuhuber (Institute of  Anatomy, University of Erlangen-NÜrnberg, Erlangen, Germany) for experimental support regarding confocal laser scanning microscopy. The perfect technical assistance of Andrea Agli is gratefully acknowledged.","volume":166,"extern":"1","date_updated":"2023-05-11T13:37:29Z","year":"2001","citation":{"ama":"Wolf D, Hallmann R, Sass G, et al. TNF-α-induced expression of adhesion molecules in the liver is under the control of TNFR1--relevance for concanavalin A-induced hepatitis. <i>Journal of Immunology</i>. 2001;166(2):1300-1307. doi:<a href=\"https://doi.org/10.4049/jimmunol.166.2.1300\">10.4049/jimmunol.166.2.1300</a>","apa":"Wolf, D., Hallmann, R., Sass, G., Sixt, M. K., Küsters, S., Fregien, B., … Tiegs, G. (2001). TNF-α-induced expression of adhesion molecules in the liver is under the control of TNFR1--relevance for concanavalin A-induced hepatitis. <i>Journal of Immunology</i>. American Association of Immunologists. <a href=\"https://doi.org/10.4049/jimmunol.166.2.1300\">https://doi.org/10.4049/jimmunol.166.2.1300</a>","chicago":"Wolf, Dominik, Rupert Hallmann, Gabriele Sass, Michael K Sixt, Sabine Küsters, Bastian Fregien, Christian Trautwein, and Gisa Tiegs. “TNF-α-Induced Expression of Adhesion Molecules in the Liver Is under the Control of TNFR1--Relevance for Concanavalin A-Induced Hepatitis.” <i>Journal of Immunology</i>. American Association of Immunologists, 2001. <a href=\"https://doi.org/10.4049/jimmunol.166.2.1300\">https://doi.org/10.4049/jimmunol.166.2.1300</a>.","ieee":"D. Wolf <i>et al.</i>, “TNF-α-induced expression of adhesion molecules in the liver is under the control of TNFR1--relevance for concanavalin A-induced hepatitis,” <i>Journal of Immunology</i>, vol. 166, no. 2. American Association of Immunologists, pp. 1300–1307, 2001.","short":"D. Wolf, R. Hallmann, G. Sass, M.K. Sixt, S. Küsters, B. Fregien, C. Trautwein, G. Tiegs, Journal of Immunology 166 (2001) 1300–1307.","mla":"Wolf, Dominik, et al. “TNF-α-Induced Expression of Adhesion Molecules in the Liver Is under the Control of TNFR1--Relevance for Concanavalin A-Induced Hepatitis.” <i>Journal of Immunology</i>, vol. 166, no. 2, American Association of Immunologists, 2001, pp. 1300–07, doi:<a href=\"https://doi.org/10.4049/jimmunol.166.2.1300\">10.4049/jimmunol.166.2.1300</a>.","ista":"Wolf D, Hallmann R, Sass G, Sixt MK, Küsters S, Fregien B, Trautwein C, Tiegs G. 2001. TNF-α-induced expression of adhesion molecules in the liver is under the control of TNFR1--relevance for concanavalin A-induced hepatitis. Journal of Immunology. 166(2), 1300–1307."},"external_id":{"pmid":["11145713"]},"doi":"10.4049/jimmunol.166.2.1300","day":"15","abstract":[{"text":"TNF-alpha has been clearly identified as central mediator of T cell activation-induced acute hepatic injury in mice, e.g., Con A hepatitis. In this model, liver injury depends on both TNFRs, i.e., the 55-kDa TNFR1 as well as the 75-kDa TNFR2. We show in this report that the hepatic TNFRs are not transcriptionally regulated, but are regulated by receptor shedding. TNF directly mediates hepatocellular death by activation of TNFR1 but also induces the expression of inflammatory proteins, such as cytokines and adhesion molecules. Here we provide evidence that resistance of TNFR1(-/-) and TNFR2(-/-) mice against Con A hepatitis is not due to an impaired production of the central mediators TNF and IFN-gamma. Con A injection results in a massive induction of ICAM-1, VCAM-1, and E-selectin in the liver. Lack of either one of both TNFRs did not change adhesion molecule expression in the livers of Con A-treated mice, presumably reflecting the fact that other endothelial cell-activating cytokines up-regulated adhesion molecule expression. However, treatment of TNFR1(-/-) and TNFR2(-/-) mice with murine rTNF revealed a predominant role for TNFR1 for the induction of hepatic adhesion molecule expression. Pretreatment with blocking Abs against E- and P-selectin or of ICAM(-/-) mice with anti-VCAM-1 Abs failed to prevent Con A hepatitis, although accumulation of the critical cell population, i.e., CD4(+) T cells was significantly inhibited. Hence, up-regulation of adhesion molecules during acute hepatitis unlikely contributes to organ injury but rather represents a defense mechanism.","lang":"eng"}],"page":"1300 - 1307","quality_controlled":"1","publisher":"American Association of Immunologists","article_type":"original","pmid":1,"_id":"3927","author":[{"full_name":"Wolf, Dominik","last_name":"Wolf","first_name":"Dominik"},{"full_name":"Hallmann, Rupert","last_name":"Hallmann","first_name":"Rupert"},{"full_name":"Sass, Gabriele","first_name":"Gabriele","last_name":"Sass"},{"last_name":"Sixt","first_name":"Michael K","full_name":"Sixt, Michael K","orcid":"0000-0002-6620-9179","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Küsters, Sabine","last_name":"Küsters","first_name":"Sabine"},{"first_name":"Bastian","last_name":"Fregien","full_name":"Fregien, Bastian"},{"full_name":"Trautwein, Christian","first_name":"Christian","last_name":"Trautwein"},{"last_name":"Tiegs","first_name":"Gisa","full_name":"Tiegs, Gisa"}],"issue":"2","publication_status":"published","date_created":"2018-12-11T12:05:56Z","article_processing_charge":"No","title":"TNF-α-induced expression of adhesion molecules in the liver is under the control of TNFR1--relevance for concanavalin A-induced hepatitis","intvolume":"       166"},{"date_published":"2001-06-01T00:00:00Z","type":"journal_article","publist_id":"2199","oa":1,"publication_identifier":{"issn":["0021-9258"]},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","status":"public","main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/S0021925819670134?via%3Dihub","open_access":"1"}],"publication":"Journal of Biological Chemistry","month":"06","oa_version":"Published Version","language":[{"iso":"eng"}],"external_id":{"pmid":["11278780"]},"date_updated":"2023-05-11T12:54:06Z","citation":{"ista":"Sixt MK, Hallmann R, Wendler O, Scharffetter Kochanek K, Sorokin L. 2001. Cell adhesion and migration properties of β2-integrin negative polymorphonuclear granulocytes on defined extracellular matrix molecules. Relevance for leukocyte extravasation. Journal of Biological Chemistry. 276(22), 18878–18887.","mla":"Sixt, Michael K., et al. “Cell Adhesion and Migration Properties of Β2-Integrin Negative Polymorphonuclear Granulocytes on Defined Extracellular Matrix Molecules. Relevance for Leukocyte Extravasation.” <i>Journal of Biological Chemistry</i>, vol. 276, no. 22, American Society for Biochemistry and Molecular Biology, 2001, pp. 18878–87, doi:<a href=\"https://doi.org/10.1074/jbc.M010898200\">10.1074/jbc.M010898200</a>.","short":"M.K. Sixt, R. Hallmann, O. Wendler, K. Scharffetter Kochanek, L. Sorokin, Journal of Biological Chemistry 276 (2001) 18878–18887.","chicago":"Sixt, Michael K, Rupert Hallmann, Olaf Wendler, Karin Scharffetter Kochanek, and Lydia Sorokin. “Cell Adhesion and Migration Properties of Β2-Integrin Negative Polymorphonuclear Granulocytes on Defined Extracellular Matrix Molecules. Relevance for Leukocyte Extravasation.” <i>Journal of Biological Chemistry</i>. American Society for Biochemistry and Molecular Biology, 2001. <a href=\"https://doi.org/10.1074/jbc.M010898200\">https://doi.org/10.1074/jbc.M010898200</a>.","ieee":"M. K. Sixt, R. Hallmann, O. Wendler, K. Scharffetter Kochanek, and L. Sorokin, “Cell adhesion and migration properties of β2-integrin negative polymorphonuclear granulocytes on defined extracellular matrix molecules. Relevance for leukocyte extravasation,” <i>Journal of Biological Chemistry</i>, vol. 276, no. 22. American Society for Biochemistry and Molecular Biology, pp. 18878–18887, 2001.","ama":"Sixt MK, Hallmann R, Wendler O, Scharffetter Kochanek K, Sorokin L. Cell adhesion and migration properties of β2-integrin negative polymorphonuclear granulocytes on defined extracellular matrix molecules. Relevance for leukocyte extravasation. <i>Journal of Biological Chemistry</i>. 2001;276(22):18878-18887. doi:<a href=\"https://doi.org/10.1074/jbc.M010898200\">10.1074/jbc.M010898200</a>","apa":"Sixt, M. K., Hallmann, R., Wendler, O., Scharffetter Kochanek, K., &#38; Sorokin, L. (2001). Cell adhesion and migration properties of β2-integrin negative polymorphonuclear granulocytes on defined extracellular matrix molecules. Relevance for leukocyte extravasation. <i>Journal of Biological Chemistry</i>. American Society for Biochemistry and Molecular Biology. <a href=\"https://doi.org/10.1074/jbc.M010898200\">https://doi.org/10.1074/jbc.M010898200</a>"},"year":"2001","abstract":[{"text":"Regulated adhesion of leukocytes to the extracellular matrix is essential for transmigration of blood vessels and subsequent migration into the stroma of inflamed tissues. Although beta(2)-integrins play an indisputable role in adhesion of polymorphonuclear granulocytes (PMN) to endothelium, we show here that beta(1)- and beta(3)-integrins but not beta(2)-integrin are essential for the adhesion to and migration on extracellular matrix molecules of the endothelial cell basement membrane and subjacent interstitial matrix. Mouse wild type and beta(2)-integrin null PMN and the progranulocytic cell line 32DC13 were employed in in vitro adhesion and migration assays using extracellular matrix molecules expressed at sites of extravasation in vivo, in particular the endothelial cell laminins 8 and 10. Wild type and beta(2)-integrin null PMN showed the same pattern of ECM binding, indicating that beta(2)-integrins do not mediate specific adhesion of PMN to the extracellular matrix molecules tested; binding was observed to the interstitial matrix molecules, fibronectin and vitronectin, via integrins alpha(5)beta(1) and alpha(v)beta(3), respectively; to laminin 10 via alpha(6)beta(1); but not to laminins 1, 2, and 8, collagen type I and IV, perlecan, or tenascin-C. PMN binding to laminins 1, 2, and 8 could not be induced despite surface expression of functionally active integrin alpha(6)beta(1), a major laminin receptor, demonstrating that expression of alpha(6)beta(1) alone is insufficient for ligand binding and suggesting the involvement of accessory factors. Nevertheless, laminins 1, 8, and 10 supported PMN migration, indicating that differential cellular signaling via laminins is independent of the extent of adhesion. The data demonstrate that adhesive and nonadhesive interactions with components of the endothelial cell basement membrane and subjacent interstitium play decisive roles in controlling PMN movement into sites of inflammation and illustrate that beta(2)-integrins are not essential for such interactions.","lang":"eng"}],"doi":"10.1074/jbc.M010898200","day":"01","extern":"1","volume":276,"acknowledgement":"We thank Dr. T. Winkler for carrying out flow cytometry analysis, Dr. Simon Goodman for providing cyclic RGD peptides and helpful discussions, and Stefanie Karosi and Thomas Samson for critical review of the manuscript. This work would not have been possible without the expert technical assistance of Friederike Pausch.","author":[{"id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","first_name":"Michael K","last_name":"Sixt","orcid":"0000-0002-6620-9179","full_name":"Sixt, Michael K"},{"full_name":"Hallmann, Rupert","first_name":"Rupert","last_name":"Hallmann"},{"full_name":"Wendler, Olaf","last_name":"Wendler","first_name":"Olaf"},{"last_name":"Scharffetter Kochanek","first_name":"Karin","full_name":"Scharffetter Kochanek, Karin"},{"full_name":"Sorokin, Lydia","last_name":"Sorokin","first_name":"Lydia"}],"issue":"22","pmid":1,"_id":"3928","scopus_import":"1","title":"Cell adhesion and migration properties of β2-integrin negative polymorphonuclear granulocytes on defined extracellular matrix molecules. Relevance for leukocyte extravasation","intvolume":"       276","publication_status":"published","date_created":"2018-12-11T12:05:56Z","article_processing_charge":"No","page":"18878 - 18887","quality_controlled":"1","article_type":"original","publisher":"American Society for Biochemistry and Molecular Biology"},{"title":"Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis","intvolume":"       153","publication_status":"published","date_created":"2018-12-11T12:05:57Z","article_processing_charge":"No","author":[{"full_name":"Sixt, Michael K","orcid":"0000-0002-6620-9179","last_name":"Sixt","first_name":"Michael K","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Engelhardt, Britta","first_name":"Britta","last_name":"Engelhardt"},{"full_name":"Pausch, Friederike","first_name":"Friederike","last_name":"Pausch"},{"full_name":"Hallmann, Rupert","first_name":"Rupert","last_name":"Hallmann"},{"last_name":"Wendler","first_name":"Olaf","full_name":"Wendler, Olaf"},{"first_name":"Lydia","last_name":"Sorokin","full_name":"Sorokin, Lydia"}],"issue":"5","pmid":1,"_id":"3930","scopus_import":"1","article_type":"original","publisher":"Rockefeller University Press","page":"933 - 946","quality_controlled":"1","abstract":[{"lang":"eng","text":"An active involvement of blood-brain barrier endothelial cell basement membranes in development of inflammatory lesions in the central nervous system (CNS) has not been considered to date. Here we investigated the molecular composition and possible function of the extracellular matrix encountered by extravasating T lymphocytes during experimental autoimmune encephalomyelitis (EAE). Endothelial basement membranes contained laminin 8 (alpha4beta1gamma1) and/or 10 (alpha5beta1gamma1) and their expression was influenced by proinflammatory cytokines or angiostatic agents. T cells emigrating into the CNS during EAE encountered two biochemically distinct basement membranes, the endothelial (containing laminins 8 and 10) and the parenchymal (containing laminins 1 and 2) basement membranes. However, inflammatory cuffs occurred exclusively around endothelial basement membranes containing laminin 8, whereas in the presence of laminin 10 no infiltration was detectable. In vitro assays using encephalitogenic T cell lines revealed adhesion to laminins 8 and 10, whereas binding to laminins 1 and 2 could not be induced. Downregulation of integrin alpha6 on cerebral endothelium at sites of T cell infiltration, plus a high turnover of laminin 8 at these sites, suggested two possible roles for laminin 8 in the endothelial basement membrane: one at the level of the endothelial cells resulting in reduced adhesion and, thereby, increased penetrability of the monolayer; and secondly at the level of the T cells providing direct signals to the transmigrating cells."}],"doi":"10.1083/jcb.153.5.933 ","day":"21","external_id":{"pmid":["11381080"]},"date_updated":"2023-05-11T12:19:36Z","citation":{"apa":"Sixt, M. K., Engelhardt, B., Pausch, F., Hallmann, R., Wendler, O., &#38; Sorokin, L. (2001). Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis. <i>Journal of Cell Biology</i>. Rockefeller University Press. <a href=\"https://doi.org/10.1083/jcb.153.5.933 \">https://doi.org/10.1083/jcb.153.5.933 </a>","ama":"Sixt MK, Engelhardt B, Pausch F, Hallmann R, Wendler O, Sorokin L. Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis. <i>Journal of Cell Biology</i>. 2001;153(5):933-946. doi:<a href=\"https://doi.org/10.1083/jcb.153.5.933 \">10.1083/jcb.153.5.933 </a>","chicago":"Sixt, Michael K, Britta Engelhardt, Friederike Pausch, Rupert Hallmann, Olaf Wendler, and Lydia Sorokin. “Endothelial Cell Laminin Isoforms, Laminins 8 and 10, Play Decisive Roles in T Cell Recruitment across the Blood-Brain Barrier in Experimental Autoimmune Encephalomyelitis.” <i>Journal of Cell Biology</i>. Rockefeller University Press, 2001. <a href=\"https://doi.org/10.1083/jcb.153.5.933 \">https://doi.org/10.1083/jcb.153.5.933 </a>.","ieee":"M. K. Sixt, B. Engelhardt, F. Pausch, R. Hallmann, O. Wendler, and L. Sorokin, “Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis,” <i>Journal of Cell Biology</i>, vol. 153, no. 5. Rockefeller University Press, pp. 933–946, 2001.","short":"M.K. Sixt, B. Engelhardt, F. Pausch, R. Hallmann, O. Wendler, L. Sorokin, Journal of Cell Biology 153 (2001) 933–946.","mla":"Sixt, Michael K., et al. “Endothelial Cell Laminin Isoforms, Laminins 8 and 10, Play Decisive Roles in T Cell Recruitment across the Blood-Brain Barrier in Experimental Autoimmune Encephalomyelitis.” <i>Journal of Cell Biology</i>, vol. 153, no. 5, Rockefeller University Press, 2001, pp. 933–46, doi:<a href=\"https://doi.org/10.1083/jcb.153.5.933 \">10.1083/jcb.153.5.933 </a>.","ista":"Sixt MK, Engelhardt B, Pausch F, Hallmann R, Wendler O, Sorokin L. 2001. Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis. Journal of Cell Biology. 153(5), 933–946."},"year":"2001","extern":"1","volume":153,"acknowledgement":"The authors thank Stefanie Karosi for careful and critical reading of the manuscript and Monika Bruckner for expert technical assistance. We are particularly grateful to Winfried Neuhuber for help with confocal microscopy and interpretation of the data. This work was supported by Deutsche Forschungsgemeinschaft grants So285/1-3 and So285/1-4 to L.M. Sorokin.","month":"05","oa_version":"Published Version","publication":"Journal of Cell Biology","language":[{"iso":"eng"}],"oa":1,"publist_id":"2198","publication_identifier":{"issn":["0021-9525"]},"date_published":"2001-05-21T00:00:00Z","type":"journal_article","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","status":"public","main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174323/","open_access":"1"}]},{"language":[{"iso":"eng"}],"month":"07","oa_version":"None","publication":"Computational Geometry: Theory and Applications","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","status":"public","publist_id":"2123","publication_identifier":{"issn":["0925-7721"]},"date_published":"2001-07-01T00:00:00Z","type":"journal_article","article_type":"original","publisher":"Elsevier","page":"191 - 204","quality_controlled":"1","title":"Shape space from deformation","intvolume":"        19","publication_status":"published","article_processing_charge":"No","date_created":"2018-12-11T12:06:22Z","author":[{"full_name":"Cheng, Ho","first_name":"Ho","last_name":"Cheng"},{"last_name":"Edelsbrunner","first_name":"Herbert","full_name":"Edelsbrunner, Herbert","orcid":"0000-0002-9823-6833","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Fu, Ping","last_name":"Fu","first_name":"Ping"}],"issue":"2-3","_id":"4001","scopus_import":"1","extern":"1","volume":19,"acknowledgement":"National Science Foundation under grants CCR-96-19542 and CCR-97-12088, and by the Army Research Office under grant DAAG55-98-1-0177.","abstract":[{"text":"The construction of shape spaces is studied from a mathematical and a computational viewpoint. A program is outlined reducing the problem to four tasks: the representation of geometry, the canonical deformation of geometry, the measuring of distance in shape space, and the selection of base shapes. The technical part of this paper focuses on the second task: the specification of a deformation mixing two or more shapes in continuously changing proportions. (C) 2001 Elsevier Science B.V All rights reserved.","lang":"eng"}],"doi":"10.1016/S0925-7721(01)00021-9","day":"01","date_updated":"2023-05-10T12:57:14Z","year":"2001","citation":{"ista":"Cheng H, Edelsbrunner H, Fu P. 2001. Shape space from deformation. Computational Geometry: Theory and Applications. 19(2–3), 191–204.","mla":"Cheng, Ho, et al. “Shape Space from Deformation.” <i>Computational Geometry: Theory and Applications</i>, vol. 19, no. 2–3, Elsevier, 2001, pp. 191–204, doi:<a href=\"https://doi.org/10.1016/S0925-7721(01)00021-9\">10.1016/S0925-7721(01)00021-9</a>.","short":"H. Cheng, H. Edelsbrunner, P. Fu, Computational Geometry: Theory and Applications 19 (2001) 191–204.","ieee":"H. Cheng, H. Edelsbrunner, and P. Fu, “Shape space from deformation,” <i>Computational Geometry: Theory and Applications</i>, vol. 19, no. 2–3. Elsevier, pp. 191–204, 2001.","chicago":"Cheng, Ho, Herbert Edelsbrunner, and Ping Fu. “Shape Space from Deformation.” <i>Computational Geometry: Theory and Applications</i>. Elsevier, 2001. <a href=\"https://doi.org/10.1016/S0925-7721(01)00021-9\">https://doi.org/10.1016/S0925-7721(01)00021-9</a>.","apa":"Cheng, H., Edelsbrunner, H., &#38; Fu, P. (2001). Shape space from deformation. <i>Computational Geometry: Theory and Applications</i>. Elsevier. <a href=\"https://doi.org/10.1016/S0925-7721(01)00021-9\">https://doi.org/10.1016/S0925-7721(01)00021-9</a>","ama":"Cheng H, Edelsbrunner H, Fu P. Shape space from deformation. <i>Computational Geometry: Theory and Applications</i>. 2001;19(2-3):191-204. doi:<a href=\"https://doi.org/10.1016/S0925-7721(01)00021-9\">10.1016/S0925-7721(01)00021-9</a>"}},{"publication":"Computational Geometry: Theory and Applications","oa_version":"None","month":"07","language":[{"iso":"eng"}],"date_published":"2001-07-01T00:00:00Z","type":"journal_article","publication_identifier":{"issn":["0925-7721"]},"publist_id":"2124","status":"public","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","_id":"4002","scopus_import":"1","author":[{"first_name":"Siu","last_name":"Cheng","full_name":"Cheng, Siu"},{"orcid":"0000-0002-9823-6833","full_name":"Edelsbrunner, Herbert","first_name":"Herbert","last_name":"Edelsbrunner","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Fu, Ping","last_name":"Fu","first_name":"Ping"},{"first_name":"Ka","last_name":"Lam","full_name":"Lam, Ka"}],"issue":"2-3","publication_status":"published","date_created":"2018-12-11T12:06:22Z","article_processing_charge":"No","title":"Design and analysis of planar shape deformation","intvolume":"        19","page":"205 - 218","quality_controlled":"1","publisher":"Elsevier","article_type":"original","date_updated":"2023-05-10T14:21:31Z","year":"2001","citation":{"ista":"Cheng S, Edelsbrunner H, Fu P, Lam K. 2001. Design and analysis of planar shape deformation. Computational Geometry: Theory and Applications. 19(2–3), 205–218.","mla":"Cheng, Siu, et al. “Design and Analysis of Planar Shape Deformation.” <i>Computational Geometry: Theory and Applications</i>, vol. 19, no. 2–3, Elsevier, 2001, pp. 205–18, doi:<a href=\"https://doi.org/10.1016/S0925-7721(01)00020-7\">10.1016/S0925-7721(01)00020-7</a>.","short":"S. Cheng, H. Edelsbrunner, P. Fu, K. Lam, Computational Geometry: Theory and Applications 19 (2001) 205–218.","ieee":"S. Cheng, H. Edelsbrunner, P. Fu, and K. Lam, “Design and analysis of planar shape deformation,” <i>Computational Geometry: Theory and Applications</i>, vol. 19, no. 2–3. Elsevier, pp. 205–218, 2001.","chicago":"Cheng, Siu, Herbert Edelsbrunner, Ping Fu, and Ka Lam. “Design and Analysis of Planar Shape Deformation.” <i>Computational Geometry: Theory and Applications</i>. Elsevier, 2001. <a href=\"https://doi.org/10.1016/S0925-7721(01)00020-7\">https://doi.org/10.1016/S0925-7721(01)00020-7</a>.","apa":"Cheng, S., Edelsbrunner, H., Fu, P., &#38; Lam, K. (2001). Design and analysis of planar shape deformation. <i>Computational Geometry: Theory and Applications</i>. Elsevier. <a href=\"https://doi.org/10.1016/S0925-7721(01)00020-7\">https://doi.org/10.1016/S0925-7721(01)00020-7</a>","ama":"Cheng S, Edelsbrunner H, Fu P, Lam K. Design and analysis of planar shape deformation. <i>Computational Geometry: Theory and Applications</i>. 2001;19(2-3):205-218. doi:<a href=\"https://doi.org/10.1016/S0925-7721(01)00020-7\">10.1016/S0925-7721(01)00020-7</a>"},"doi":"10.1016/S0925-7721(01)00020-7","day":"01","abstract":[{"text":"Shape deformation refers to the continuous change of one geometric object to another. We develop a software tool for planning, analyzing and visualizing deformations between two shapes in R-2. The deformation is generated automatically without any user intervention or specification of feature correspondences. A unique property of the tool is the explicit availability of a two-dimensional shape space, which can be used for designing the deformation either automatically by following constraints and objectives or manually by drawing deformation paths.","lang":"eng"}],"acknowledgement":"NSF under grants CCR-96-19542 and CCR-97-12088.","volume":19,"extern":"1"},{"main_file_link":[{"url":"https://dl.acm.org/doi/10.5555/365411.365418"}],"status":"public","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","extern":"1","publication_identifier":{"isbn":["9780898714906"]},"day":"09","publist_id":"2120","abstract":[{"text":"This paper describes an algorithm for maintaining an approximating triangulation of a deforming surface in R-3. The triangulation adapts dynamically to changing shape, curvature, and topology of the surface.","lang":"eng"}],"citation":{"ama":"Cheng H, Dey T, Edelsbrunner H, Sullivan J. Dynamic skin triangulation. In: <i>Proceedings of the 12th Annual ACM-SIAM Symposium on Discrete Algorithms</i>. SIAM; 2001:47-56.","apa":"Cheng, H., Dey, T., Edelsbrunner, H., &#38; Sullivan, J. (2001). Dynamic skin triangulation. In <i>Proceedings of the 12th annual ACM-SIAM symposium on Discrete algorithms</i> (pp. 47–56). Washington, DC, USA : SIAM.","ieee":"H. Cheng, T. Dey, H. Edelsbrunner, and J. Sullivan, “Dynamic skin triangulation,” in <i>Proceedings of the 12th annual ACM-SIAM symposium on Discrete algorithms</i>, Washington, DC, USA , 2001, pp. 47–56.","chicago":"Cheng, Ho, Tamal Dey, Herbert Edelsbrunner, and John Sullivan. “Dynamic Skin Triangulation.” In <i>Proceedings of the 12th Annual ACM-SIAM Symposium on Discrete Algorithms</i>, 47–56. SIAM, 2001.","short":"H. Cheng, T. Dey, H. Edelsbrunner, J. Sullivan, in:, Proceedings of the 12th Annual ACM-SIAM Symposium on Discrete Algorithms, SIAM, 2001, pp. 47–56.","mla":"Cheng, Ho, et al. “Dynamic Skin Triangulation.” <i>Proceedings of the 12th Annual ACM-SIAM Symposium on Discrete Algorithms</i>, SIAM, 2001, pp. 47–56.","ista":"Cheng H, Dey T, Edelsbrunner H, Sullivan J. 2001. Dynamic skin triangulation. Proceedings of the 12th annual ACM-SIAM symposium on Discrete algorithms. SODA: Symposium on Discrete Algorithms, 47–56."},"year":"2001","date_updated":"2023-05-10T12:35:44Z","type":"conference","date_published":"2001-01-09T00:00:00Z","publisher":"SIAM","conference":{"end_date":"2001-01-09","location":"Washington, DC, USA ","start_date":"2001-01-07","name":"SODA: Symposium on Discrete Algorithms"},"quality_controlled":"1","page":"47 - 56","language":[{"iso":"eng"}],"date_created":"2018-12-11T12:06:23Z","article_processing_charge":"No","publication_status":"published","oa_version":"None","title":"Dynamic skin triangulation","month":"01","_id":"4005","publication":"Proceedings of the 12th annual ACM-SIAM symposium on Discrete algorithms","author":[{"full_name":"Cheng, Ho","first_name":"Ho","last_name":"Cheng"},{"full_name":"Dey, Tamal","last_name":"Dey","first_name":"Tamal"},{"first_name":"Herbert","last_name":"Edelsbrunner","orcid":"0000-0002-9823-6833","full_name":"Edelsbrunner, Herbert","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Sullivan, John","first_name":"John","last_name":"Sullivan"}]},{"year":"2001","citation":{"ista":"Edelsbrunner H. 2001. 180 wrapped tubes. Journal of Universal Computer Science. 7(5), 379–399.","mla":"Edelsbrunner, Herbert. “180 Wrapped Tubes.” <i>Journal of Universal Computer Science</i>, vol. 7, no. 5, Springer, 2001, pp. 379–99, doi:<a href=\"https://doi.org/10.3217/jucs-007-05-0379\">10.3217/jucs-007-05-0379</a>.","short":"H. Edelsbrunner, Journal of Universal Computer Science 7 (2001) 379–399.","chicago":"Edelsbrunner, Herbert. “180 Wrapped Tubes.” <i>Journal of Universal Computer Science</i>. Springer, 2001. <a href=\"https://doi.org/10.3217/jucs-007-05-0379\">https://doi.org/10.3217/jucs-007-05-0379</a>.","ieee":"H. Edelsbrunner, “180 wrapped tubes,” <i>Journal of Universal Computer Science</i>, vol. 7, no. 5. Springer, pp. 379–399, 2001.","apa":"Edelsbrunner, H. (2001). 180 wrapped tubes. <i>Journal of Universal Computer Science</i>. Springer. <a href=\"https://doi.org/10.3217/jucs-007-05-0379\">https://doi.org/10.3217/jucs-007-05-0379</a>","ama":"Edelsbrunner H. 180 wrapped tubes. <i>Journal of Universal Computer Science</i>. 2001;7(5):379-399. doi:<a href=\"https://doi.org/10.3217/jucs-007-05-0379\">10.3217/jucs-007-05-0379</a>"},"date_updated":"2023-05-10T12:39:54Z","type":"journal_article","date_published":"2001-05-28T00:00:00Z","day":"28","publication_identifier":{"issn":["0948-695X"]},"doi":"10.3217/jucs-007-05-0379","publist_id":"2121","abstract":[{"lang":"eng","text":"The 180 models collected in this paper are produced by sampling and wrapping point sets on tubes. The surfaces are represented as triangulated 2-manifolds and available as st1-files from the author's web site at www.cs.duke.edu/similar toedels. Each tube is obtained by thickening a circle or a smooth torus knot, and for some we use the degrees of freedom in the thickening process to encode meaningful information, such as curvature or torsion."}],"volume":7,"status":"public","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","extern":"1","_id":"4006","publication":"Journal of Universal Computer Science","issue":"5","author":[{"id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","full_name":"Edelsbrunner, Herbert","orcid":"0000-0002-9823-6833","last_name":"Edelsbrunner","first_name":"Herbert"}],"article_processing_charge":"No","date_created":"2018-12-11T12:06:24Z","oa_version":"None","publication_status":"published","intvolume":"         7","month":"05","title":"180 wrapped tubes","quality_controlled":"1","page":"379 - 399","language":[{"iso":"eng"}],"publisher":"Springer","article_type":"original"},{"month":"04","oa_version":"None","publication":"Discrete & Computational Geometry","language":[{"iso":"eng"}],"publist_id":"2122","publication_identifier":{"issn":["0179-5376"]},"type":"journal_article","date_published":"2001-04-04T00:00:00Z","status":"public","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","intvolume":"        25","title":"Dynamic skin triangulation","date_created":"2018-12-11T12:06:24Z","article_processing_charge":"No","publication_status":"published","issue":"4","author":[{"full_name":"Cheng, Ho","first_name":"Ho","last_name":"Cheng"},{"full_name":"Dey, Tamal","first_name":"Tamal","last_name":"Dey"},{"id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","full_name":"Edelsbrunner, Herbert","orcid":"0000-0002-9823-6833","last_name":"Edelsbrunner","first_name":"Herbert"},{"full_name":"Sullivan, John","first_name":"John","last_name":"Sullivan"}],"scopus_import":"1","_id":"4007","article_type":"original","publisher":"Springer","quality_controlled":"1","page":"525 - 568","abstract":[{"lang":"eng","text":"This paper describes an algorithm for maintaining an approximating triangulation of a deforming surface in R 3 . The surface is the envelope of an infinite family of spheres defined and controlled by a finite collection of weighted points. The triangulation adapts dynamically to changing shape, curvature, and topology of the surface. "}],"day":"04","doi":"10.1007/s00454-001-0007-1","citation":{"mla":"Cheng, Ho, et al. “Dynamic Skin Triangulation.” <i>Discrete &#38; Computational Geometry</i>, vol. 25, no. 4, Springer, 2001, pp. 525–68, doi:<a href=\"https://doi.org/10.1007/s00454-001-0007-1\">10.1007/s00454-001-0007-1</a>.","short":"H. Cheng, T. Dey, H. Edelsbrunner, J. Sullivan, Discrete &#38; Computational Geometry 25 (2001) 525–568.","ista":"Cheng H, Dey T, Edelsbrunner H, Sullivan J. 2001. Dynamic skin triangulation. Discrete &#38; Computational Geometry. 25(4), 525–568.","apa":"Cheng, H., Dey, T., Edelsbrunner, H., &#38; Sullivan, J. (2001). Dynamic skin triangulation. <i>Discrete &#38; Computational Geometry</i>. Springer. <a href=\"https://doi.org/10.1007/s00454-001-0007-1\">https://doi.org/10.1007/s00454-001-0007-1</a>","ama":"Cheng H, Dey T, Edelsbrunner H, Sullivan J. Dynamic skin triangulation. <i>Discrete &#38; Computational Geometry</i>. 2001;25(4):525-568. doi:<a href=\"https://doi.org/10.1007/s00454-001-0007-1\">10.1007/s00454-001-0007-1</a>","chicago":"Cheng, Ho, Tamal Dey, Herbert Edelsbrunner, and John Sullivan. “Dynamic Skin Triangulation.” <i>Discrete &#38; Computational Geometry</i>. Springer, 2001. <a href=\"https://doi.org/10.1007/s00454-001-0007-1\">https://doi.org/10.1007/s00454-001-0007-1</a>.","ieee":"H. Cheng, T. Dey, H. Edelsbrunner, and J. Sullivan, “Dynamic skin triangulation,” <i>Discrete &#38; Computational Geometry</i>, vol. 25, no. 4. Springer, pp. 525–568, 2001."},"year":"2001","date_updated":"2023-05-10T12:45:59Z","extern":"1","volume":25,"acknowledgement":"NSF under grant DMS- 98-73945, ARO under grant DAAG55-98-1-0177, NSF under grants CCR-96- 19542 and CCR-97-12088."},{"extern":"1","acknowledgement":"We thank many colleagues who provided reagents that enabled us to test axin1 and several other genes as candidates for the mbl mutation. In particular, we are indebted to Masahiko Hibi, Ken Irvine, Antonio Jacinto, Yun-Jin Jiang, Julian Lewis, and Tom Vogt for help and advice. We thank Ajay Chitnis and Dana Zivkovic for providing information prior to publication. This study was supported primarily by grants from the EMBO and EC to C.P.H., Wellcome Trust and EC to S.W.W., from the MRC to D.S., from Naito to M.T., from the DHGP to G.J.R. and R.G., and from the CRC/ICR to T.D. P.C. was supported by a PhD studentship from Fundação para a Ciência e Tecnologia, Programa PRAXIS XXI. S.W.W. is a Wellcome Trust Senior Research Fellow.\r\n\r\nThe publication costs of this article were defrayed in part by payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 USC section 1734 solely to indicate this fact.","volume":15,"external_id":{"pmid":["11390362"]},"citation":{"mla":"Heisenberg, Carl-Philipp J., et al. “A Mutation in the Gsk3-Binding Domain of Zebrafish Masterblind/Axin1 Leads to a Fate Transformation of Telencephalon and Eyes to Diencephalon.” <i>Genes and Development</i>, vol. 15, no. 11, Cold Spring Harbor Laboratory Press, 2001, pp. 1427–34, doi:<a href=\"https://doi.org/10.1101/gad.194301\">10.1101/gad.194301</a>.","short":"C.-P.J. Heisenberg, C. Houart, M. Take Uchi, G. Rauch, N. Young, P. Coutinho, I. Masai, L. Caneparo, M. Concha, R. Geisler, T. Dale, S. Wilson, D. Stemple, Genes and Development 15 (2001) 1427–1434.","ista":"Heisenberg C-PJ, Houart C, Take Uchi M, Rauch G, Young N, Coutinho P, Masai I, Caneparo L, Concha M, Geisler R, Dale T, Wilson S, Stemple D. 2001. A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon. Genes and Development. 15(11), 1427–1434.","apa":"Heisenberg, C.-P. J., Houart, C., Take Uchi, M., Rauch, G., Young, N., Coutinho, P., … Stemple, D. (2001). A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon. <i>Genes and Development</i>. Cold Spring Harbor Laboratory Press. <a href=\"https://doi.org/10.1101/gad.194301\">https://doi.org/10.1101/gad.194301</a>","ama":"Heisenberg C-PJ, Houart C, Take Uchi M, et al. A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon. <i>Genes and Development</i>. 2001;15(11):1427-1434. doi:<a href=\"https://doi.org/10.1101/gad.194301\">10.1101/gad.194301</a>","chicago":"Heisenberg, Carl-Philipp J, Corinne Houart, Masaya Take Uchi, Gerd Rauch, Neville Young, Pedro Coutinho, Ichiro Masai, et al. “A Mutation in the Gsk3-Binding Domain of Zebrafish Masterblind/Axin1 Leads to a Fate Transformation of Telencephalon and Eyes to Diencephalon.” <i>Genes and Development</i>. Cold Spring Harbor Laboratory Press, 2001. <a href=\"https://doi.org/10.1101/gad.194301\">https://doi.org/10.1101/gad.194301</a>.","ieee":"C.-P. J. Heisenberg <i>et al.</i>, “A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon,” <i>Genes and Development</i>, vol. 15, no. 11. Cold Spring Harbor Laboratory Press, pp. 1427–1434, 2001."},"year":"2001","date_updated":"2023-05-10T12:27:02Z","abstract":[{"lang":"eng","text":"Zebrafish embryos homozygous for the masterblind (mb1) mutation exhibit a striking phenotype in which the eyes and telencephalon are reduced or absent and diencephalic fates expand to the front of the brain. Here we show that mb1(-/-) embryos carry an amino-acid change at a conserved site in the Wnt pathway scaffolding protein, Axin1. The amino-acid substitution present in the mbl allele abolishes the binding of Axin to Gsk3 and affects Tcf-dependent transcription. Therefore, Gsk3 activity may be decreased in mbl(-/-) embryos and in support of this possibility, overexpression of either wild-type Axin1 or Gsk3 beta can restore eye and telencephalic fates to mb1(-/-) embryos. Our data reveal a crucial role for Axin1-dependent inhibition of the Wnt pathway in the early regional subdivision of the anterior neural plate into telencephalic, diencephalic, and eye-forming territories."}],"day":"01","doi":"10.1101/gad.194301","quality_controlled":"1","page":"1427 - 1434","article_type":"original","publisher":"Cold Spring Harbor Laboratory Press","issue":"11","author":[{"id":"39427864-F248-11E8-B48F-1D18A9856A87","first_name":"Carl-Philipp J","last_name":"Heisenberg","orcid":"0000-0002-0912-4566","full_name":"Heisenberg, Carl-Philipp J"},{"first_name":"Corinne","last_name":"Houart","full_name":"Houart, Corinne"},{"full_name":"Take Uchi, Masaya","last_name":"Take Uchi","first_name":"Masaya"},{"first_name":"Gerd","last_name":"Rauch","full_name":"Rauch, Gerd"},{"first_name":"Neville","last_name":"Young","full_name":"Young, Neville"},{"full_name":"Coutinho, Pedro","first_name":"Pedro","last_name":"Coutinho"},{"full_name":"Masai, Ichiro","first_name":"Ichiro","last_name":"Masai"},{"full_name":"Caneparo, Luca","first_name":"Luca","last_name":"Caneparo"},{"last_name":"Concha","first_name":"Miguel","full_name":"Concha, Miguel"},{"first_name":"Robert","last_name":"Geisler","full_name":"Geisler, Robert"},{"full_name":"Dale, Trevor","last_name":"Dale","first_name":"Trevor"},{"full_name":"Wilson, Stephen","last_name":"Wilson","first_name":"Stephen"},{"full_name":"Stemple, Derek","first_name":"Derek","last_name":"Stemple"}],"pmid":1,"_id":"4200","intvolume":"        15","title":"A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon","date_created":"2018-12-11T12:07:33Z","article_processing_charge":"No","publication_status":"published","status":"public","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC312705/","open_access":"1"}],"type":"journal_article","date_published":"2001-06-01T00:00:00Z","publist_id":"1916","oa":1,"publication_identifier":{"issn":["0890-9369"]},"language":[{"iso":"eng"}],"publication":"Genes and Development","month":"06","oa_version":"Published Version"},{"type":"journal_article","date_published":"2001-02-01T00:00:00Z","publication_identifier":{"issn":["0022-2844"]},"publist_id":"1886","status":"public","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publication":"Journal of Molecular Evolution","oa_version":"None","month":"02","language":[{"iso":"eng"}],"year":"2001","citation":{"ieee":"J. P. Bollback and J. Huelsenbeck, “Phylogeny, genome evolution, and host specificity of single-stranded RNA bacteriophage (Family Leviviridae),” <i>Journal of Molecular Evolution</i>, vol. 52, no. 2. Springer, pp. 117–128, 2001.","chicago":"Bollback, Jonathan P, and John Huelsenbeck. “Phylogeny, Genome Evolution, and Host Specificity of Single-Stranded RNA Bacteriophage (Family Leviviridae).” <i>Journal of Molecular Evolution</i>. Springer, 2001. <a href=\"https://doi.org/10.1007/s002390010140\">https://doi.org/10.1007/s002390010140</a>.","ama":"Bollback JP, Huelsenbeck J. Phylogeny, genome evolution, and host specificity of single-stranded RNA bacteriophage (Family Leviviridae). <i>Journal of Molecular Evolution</i>. 2001;52(2):117-128. doi:<a href=\"https://doi.org/10.1007/s002390010140\">10.1007/s002390010140</a>","apa":"Bollback, J. P., &#38; Huelsenbeck, J. (2001). Phylogeny, genome evolution, and host specificity of single-stranded RNA bacteriophage (Family Leviviridae). <i>Journal of Molecular Evolution</i>. Springer. <a href=\"https://doi.org/10.1007/s002390010140\">https://doi.org/10.1007/s002390010140</a>","ista":"Bollback JP, Huelsenbeck J. 2001. Phylogeny, genome evolution, and host specificity of single-stranded RNA bacteriophage (Family Leviviridae). Journal of Molecular Evolution. 52(2), 117–128.","mla":"Bollback, Jonathan P., and John Huelsenbeck. “Phylogeny, Genome Evolution, and Host Specificity of Single-Stranded RNA Bacteriophage (Family Leviviridae).” <i>Journal of Molecular Evolution</i>, vol. 52, no. 2, Springer, 2001, pp. 117–28, doi:<a href=\"https://doi.org/10.1007/s002390010140\">10.1007/s002390010140</a>.","short":"J.P. Bollback, J. Huelsenbeck, Journal of Molecular Evolution 52 (2001) 117–128."},"date_updated":"2023-05-10T12:23:49Z","external_id":{"pmid":["11231891"]},"day":"01","doi":"10.1007/s002390010140","abstract":[{"lang":"eng","text":"Bacteriophage of the family Leviviridae have played an important role in molecular biology where representative species, such as Qβ and MS2, have been studied as model systems for replication, translation, and the role of secondary structure in gene regulation. Using nucleotide sequences from the coat and replicase genes we present the first statistical estimate of phylogeny for the family Leviviridae using maximum-likelihood and Bayesian estimation. Our analyses reveal that the coliphage species are a monophyletic group consisting of two clades representing the genera Levivirus and Allolevivirus. The Pseudomonas species PP7 diverged from its common ancestor with the coliphage prior to the ancient split between these genera and their subsequent diversification. Differences in genome size, gene composition, and gene expression are shown with a high probability to have changed along the lineage leading to the Allolevivirus through gene expansion. The change in genome size of the Allolevivirus ancestor may have catalyzed subsequent changes that led to their current genome organization and gene expression."}],"acknowledgement":"We thank Kenneth G. Karol, Andrea J. Betancourt, Daven C. Presgraves, and Bret Larget for helpful comments and\r\nsuggestions. This work was supported by funding from the National Science Foundation (MCB-0075404 and DEB-0075406) to J.P.H.","volume":52,"extern":"1","_id":"4229","pmid":1,"issue":"2","author":[{"first_name":"Jonathan P","last_name":"Bollback","orcid":"0000-0002-4624-4612","full_name":"Bollback, Jonathan P","id":"2C6FA9CC-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Huelsenbeck","first_name":"John","full_name":"Huelsenbeck, John"}],"date_created":"2018-12-11T12:07:43Z","article_processing_charge":"No","publication_status":"published","intvolume":"        52","title":"Phylogeny, genome evolution, and host specificity of single-stranded RNA bacteriophage (Family Leviviridae)","quality_controlled":"1","page":"117 - 128","publisher":"Springer","article_type":"original"},{"month":"07","oa_version":"None","publication":"Trends in Ecology and Evolution","language":[{"iso":"eng"}],"publist_id":"1828","publication_identifier":{"issn":["0169-5347"]},"date_published":"2001-07-01T00:00:00Z","type":"journal_article","status":"public","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","title":"Theory and speciation","intvolume":"        16","publication_status":"published","date_created":"2018-12-11T12:07:55Z","article_processing_charge":"No","author":[{"full_name":"Turelli, Michael","last_name":"Turelli","first_name":"Michael"},{"last_name":"Barton","first_name":"Nicholas H","full_name":"Barton, Nicholas H","orcid":"0000-0002-8548-5240","id":"4880FE40-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Coyne, Jerry","last_name":"Coyne","first_name":"Jerry"}],"issue":"7","pmid":1,"_id":"4264","article_type":"original","publisher":"Cell Press","page":"330 - 343","quality_controlled":"1","abstract":[{"text":"The study of speciation has become one of the most active areas of evolutionary biology, and substantial progress has been made in documenting and understanding phenomena ranging from sympatric speciation and reinforcement to the evolutionary genetics of postzygotic isolation. This progress has been driven largely by empirical results, and most useful theoretical work has concentrated on making sense of empirical patterns. Given the complexity of speciation, mathematical theory is subordinate to verbal theory and generalizations about data. Nevertheless, mathematical theory can provide a useful classification of verbal theories; can help determine the biological plausibility of verbal theories; can determine whether alternative mechanisms of speciation are consistent with empirical patterns; and can occasionally provide predictions that go beyond empirical generalizations. We discuss recent examples of progress in each of these areas.","lang":"eng"}],"doi":"10.1016/S0169-5347(01)02177-2","day":"01","external_id":{"pmid":["11403865"]},"date_updated":"2023-05-10T12:16:55Z","citation":{"short":"M. Turelli, N.H. Barton, J. Coyne, Trends in Ecology and Evolution 16 (2001) 330–343.","mla":"Turelli, Michael, et al. “Theory and Speciation.” <i>Trends in Ecology and Evolution</i>, vol. 16, no. 7, Cell Press, 2001, pp. 330–43, doi:<a href=\"https://doi.org/10.1016/S0169-5347(01)02177-2\">10.1016/S0169-5347(01)02177-2</a>.","ista":"Turelli M, Barton NH, Coyne J. 2001. Theory and speciation. Trends in Ecology and Evolution. 16(7), 330–343.","apa":"Turelli, M., Barton, N. H., &#38; Coyne, J. (2001). Theory and speciation. <i>Trends in Ecology and Evolution</i>. Cell Press. <a href=\"https://doi.org/10.1016/S0169-5347(01)02177-2\">https://doi.org/10.1016/S0169-5347(01)02177-2</a>","ama":"Turelli M, Barton NH, Coyne J. Theory and speciation. <i>Trends in Ecology and Evolution</i>. 2001;16(7):330-343. doi:<a href=\"https://doi.org/10.1016/S0169-5347(01)02177-2\">10.1016/S0169-5347(01)02177-2</a>","chicago":"Turelli, Michael, Nicholas H Barton, and Jerry Coyne. “Theory and Speciation.” <i>Trends in Ecology and Evolution</i>. Cell Press, 2001. <a href=\"https://doi.org/10.1016/S0169-5347(01)02177-2\">https://doi.org/10.1016/S0169-5347(01)02177-2</a>.","ieee":"M. Turelli, N. H. Barton, and J. Coyne, “Theory and speciation,” <i>Trends in Ecology and Evolution</i>, vol. 16, no. 7. Cell Press, pp. 330–343, 2001."},"year":"2001","extern":"1","volume":16,"acknowledgement":"We thank D. Bolnick, B. Fitzpatrick, S. Gavrilets, R. Haygood, C.D. Jones, M. Kirkpatrick, A. Kondrashov, J.B. Mullet, S.V. Nuzhdin, H.A. Orr, T.D. Price, T. Prout, D.W. Schemske, D. Schluter, M.R. Servedio and P.S. Ward for discussion and comments. Some of these reviewers disagree with our conclusions. This work was supported by US National Science Foundation grants DEB 9527808 and DEB 0089716 to MT, grants from the Darwin Trust of Edinburgh and the Biotechnology and Biological Sciences Research Council (GRJ/76057, GR/H/09928) to NHB, and National Institutes of Health grant R01 GM58260 to JAC. "}]