---
_id: '2493'
abstract:
- lang: eng
text: 'A specific antiserum against substance P receptor (SPR) labels nonprincipal
neurons in the cerebral cortex of the rat (T. Kaneko et al. [1994], Neuroscience
60:199-211; Y. Nakaya et al. [1994], J. Comp. Neurol. 347:249-274). In the present
study, we aimed to identify the types of SPR- immunoreactive neurons in the hippocampus
according to their content of neurochemical markers, which label interneuron populations
with distinct termination patterns. Markers for perisomatic inhibitory cells,
parvalbumin and cholecystokinin (CCK), colocalized with SPR in pyramidallike basket
cells in the dentate gyrus and in large multipolar or bitufted cells within all
hippocampal subfields respectively. A dense meshwork of SPR-immunoreactive spiny
dendrites in the hilus and stratum lucidum of the CA3 region belonged largely
to inhibitory cells terminating in the distal dendritic region of granule cells,
as indicated by the somatostatin and neuropeptide Y (NPY) content. In addition,
SPR and NPY were colocalized in numerous multipolar interneurons with dendrites
branching close to the soma. Twenty-five percent of the SPR-immunoreactive cells
overlapped with calretinin-positive neurons in all hippocampal subfields, showing
that interneurons specialized to contact other gamma-aminobutyric acid-ergic cells
may also contain SPR. On the basis of the known termination pattern of the colocalized
markers, we conclude that SPR-positive interneurons are functionally heterogeneous
and participate in different inhibitory processes: (1) perisomatic inhibition
of principal cells (CCK-containing cells, and parvalbumin-positive cells in the
dentate gyrus), (2) feedback dendritic inhibition in the entorhinal termination
zone (somatostatin and NPY-containing cells), and (3) innervation of other interneurons
(calretinin-containing cells).'
acknowledgement: This sudy was supported by grants from the Human Frontier Science
Program Organisation, the Howard Hughes Medical Institute, and OTKA (T 16942) Hungary.We
are grateful to Dr. K.G. Baimbridge and to Dr. M.R.Celio (calbindin and parvalbumin),
Dr. T. Go ̈rcs (CCK, VIP,NPY, and somatostatin), Dr. J.H. Rogers (calretinin), andDr.
C.G. Beaulieau (GABA) for kind gifts of antisera. The excellent technical assistance
of Mrs. E. Borok, Mrs. A.Z.Szabo, and Mr. G. Terstyanszky is also acknowledged
article_processing_charge: No
article_type: original
author:
- first_name: László
full_name: Acsády, László
last_name: Acsády
- first_name: István
full_name: Katona, István
last_name: Katona
- first_name: Attila
full_name: Gulyás, Attila
last_name: Gulyás
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Tamás
full_name: Freund, Tamás
last_name: Freund
citation:
ama: Acsády L, Katona I, Gulyás A, Shigemoto R, Freund T. Immunostaining for substance
P receptor labels GABAergic cells with distinct termination patterns in the hippocampus.
Journal of Comparative Neurology. 1997;378(3):320-336. doi:10.1002/(SICI)1096-9861(19970217)378:3<320::AID-CNE2>3.0.CO;2-5
apa: Acsády, L., Katona, I., Gulyás, A., Shigemoto, R., & Freund, T. (1997).
Immunostaining for substance P receptor labels GABAergic cells with distinct termination
patterns in the hippocampus. Journal of Comparative Neurology. Wiley-Blackwell.
https://doi.org/10.1002/(SICI)1096-9861(19970217)378:3<320::AID-CNE2>3.0.CO;2-5
chicago: Acsády, László, István Katona, Attila Gulyás, Ryuichi Shigemoto, and Tamás
Freund. “Immunostaining for Substance P Receptor Labels GABAergic Cells with Distinct
Termination Patterns in the Hippocampus.” Journal of Comparative Neurology.
Wiley-Blackwell, 1997. https://doi.org/10.1002/(SICI)1096-9861(19970217)378:3<320::AID-CNE2>3.0.CO;2-5.
ieee: L. Acsády, I. Katona, A. Gulyás, R. Shigemoto, and T. Freund, “Immunostaining
for substance P receptor labels GABAergic cells with distinct termination patterns
in the hippocampus,” Journal of Comparative Neurology, vol. 378, no. 3.
Wiley-Blackwell, pp. 320–336, 1997.
ista: Acsády L, Katona I, Gulyás A, Shigemoto R, Freund T. 1997. Immunostaining
for substance P receptor labels GABAergic cells with distinct termination patterns
in the hippocampus. Journal of Comparative Neurology. 378(3), 320–336.
mla: Acsády, László, et al. “Immunostaining for Substance P Receptor Labels GABAergic
Cells with Distinct Termination Patterns in the Hippocampus.” Journal of Comparative
Neurology, vol. 378, no. 3, Wiley-Blackwell, 1997, pp. 320–36, doi:10.1002/(SICI)1096-9861(19970217)378:3<320::AID-CNE2>3.0.CO;2-5.
short: L. Acsády, I. Katona, A. Gulyás, R. Shigemoto, T. Freund, Journal of Comparative
Neurology 378 (1997) 320–336.
date_created: 2018-12-11T11:57:59Z
date_published: 1997-02-17T00:00:00Z
date_updated: 2022-08-22T13:43:18Z
day: '17'
doi: 10.1002/(SICI)1096-9861(19970217)378:3<320::AID-CNE2>3.0.CO;2-5
extern: '1'
external_id:
pmid:
- '9034894'
intvolume: ' 378'
issue: '3'
language:
- iso: eng
month: '02'
oa_version: None
page: 320 - 336
pmid: 1
publication: Journal of Comparative Neurology
publication_identifier:
issn:
- 0021-9967
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4408'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Immunostaining for substance P receptor labels GABAergic cells with distinct
termination patterns in the hippocampus
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 378
year: '1997'
...
---
_id: '2575'
abstract:
- lang: eng
text: It was examined electron microscopically in the rat if a metabotropic glutamate
receptor, mGluR7, might be localized in axon terminals of nociceptive, primary
afferent fibers in laminae I and II of the spinal dorsal horn. Nociceptive nature
of axon terminals showing mGluR7-like immunoreactivity (mGluR7-LI) was indicated
by binding to the isolectin I-B4 from Griffonia simplicifolia (I-B4), or by substance
P-like immunoreactivity (SP-LI). Axon terminals labeled with immunogold particles
indicating mGluR7-LI were usually filled with round synaptic vesicles and were
in asymmetric synaptic contact with dendritic or somatic profiles; occasionally
they contained pleomorphic vesicles and were in symmetric synaptic contact with
somatic profiles in lamina II. The double-labeling studies revealed that most
of axon terminals with I-B4 labeling as well as a small population of axon terminals
with SP-LI, showed mGluR7-LI. About one-third or much smaller population of axon
terminals with mGluR7-LI in laminae I and II were labeled, respectively, with
I-B4 or SP-LI; these were in asymmetric synaptic contact with dendritic profiles.
acknowledgement: We are grateful for photographic help of Mr. Akira Uesugi. We also
express our gratitude for the support of Drs. Satoru Fukuchi, Ritsu Hayashi, Sohzaburo
Hayashi, Mizuho Katsurada, Hitoshi Kawai, Yutaka Kitani, Toshihiko Kuroda, Keiko
Kumagai, Hiroshi Matsubara, Hiroshi Matsushima, Chisato Minakuchi, Gonpei Niwa,
Hajime Oda, Masahiko Ohbayashi, Sei-ichi Ohbayashi, Hiroyasu Ohtsuka, Shigeo Tamaki,
Eizo Watanabe, Kazuo Yoshino, and Toshiaki Yoshino. This work was supported in part
by Grant-in-Aid from Ministry of Education, Science, Culture and Sports of Japan.
article_processing_charge: No
article_type: original
author:
- first_name: He
full_name: Li, He
last_name: Li
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Ayae
full_name: Kinoshita, Ayae
last_name: Kinoshita
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Sakashi
full_name: Nomura, Sakashi
last_name: Nomura
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: 'Li H, Ohishi H, Kinoshita A, Shigemoto R, Nomura S, Mizuno N. Localization
of a metabotropic glutamate receptor, mGluR7, in axon terminals of presumed nociceptive,
primary afferent fibers in the superficial layers of the spinal dorsal horn: An
electron microscope study in the rat. Neuroscience Letters. 1997;223(3):153-156.
doi:10.1016/S0304-3940(97)13429-2'
apa: 'Li, H., Ohishi, H., Kinoshita, A., Shigemoto, R., Nomura, S., & Mizuno,
N. (1997). Localization of a metabotropic glutamate receptor, mGluR7, in axon
terminals of presumed nociceptive, primary afferent fibers in the superficial
layers of the spinal dorsal horn: An electron microscope study in the rat. Neuroscience
Letters. Elsevier. https://doi.org/10.1016/S0304-3940(97)13429-2'
chicago: 'Li, He, Hitoshi Ohishi, Ayae Kinoshita, Ryuichi Shigemoto, Sakashi Nomura,
and Noboru Mizuno. “Localization of a Metabotropic Glutamate Receptor, MGluR7,
in Axon Terminals of Presumed Nociceptive, Primary Afferent Fibers in the Superficial
Layers of the Spinal Dorsal Horn: An Electron Microscope Study in the Rat.” Neuroscience
Letters. Elsevier, 1997. https://doi.org/10.1016/S0304-3940(97)13429-2.'
ieee: 'H. Li, H. Ohishi, A. Kinoshita, R. Shigemoto, S. Nomura, and N. Mizuno, “Localization
of a metabotropic glutamate receptor, mGluR7, in axon terminals of presumed nociceptive,
primary afferent fibers in the superficial layers of the spinal dorsal horn: An
electron microscope study in the rat,” Neuroscience Letters, vol. 223,
no. 3. Elsevier, pp. 153–156, 1997.'
ista: 'Li H, Ohishi H, Kinoshita A, Shigemoto R, Nomura S, Mizuno N. 1997. Localization
of a metabotropic glutamate receptor, mGluR7, in axon terminals of presumed nociceptive,
primary afferent fibers in the superficial layers of the spinal dorsal horn: An
electron microscope study in the rat. Neuroscience Letters. 223(3), 153–156.'
mla: 'Li, He, et al. “Localization of a Metabotropic Glutamate Receptor, MGluR7,
in Axon Terminals of Presumed Nociceptive, Primary Afferent Fibers in the Superficial
Layers of the Spinal Dorsal Horn: An Electron Microscope Study in the Rat.” Neuroscience
Letters, vol. 223, no. 3, Elsevier, 1997, pp. 153–56, doi:10.1016/S0304-3940(97)13429-2.'
short: H. Li, H. Ohishi, A. Kinoshita, R. Shigemoto, S. Nomura, N. Mizuno, Neuroscience
Letters 223 (1997) 153–156.
date_created: 2018-12-11T11:58:28Z
date_published: 1997-02-28T00:00:00Z
date_updated: 2022-08-22T13:06:30Z
day: '28'
doi: 10.1016/S0304-3940(97)13429-2
extern: '1'
external_id:
pmid:
- '9080455'
intvolume: ' 223'
issue: '3'
language:
- iso: eng
month: '02'
oa_version: None
page: 153 - 156
pmid: 1
publication: Neuroscience Letters
publication_identifier:
issn:
- 0304-3940
publication_status: published
publisher: Elsevier
publist_id: '4322'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Localization of a metabotropic glutamate receptor, mGluR7, in axon terminals
of presumed nociceptive, primary afferent fibers in the superficial layers of the
spinal dorsal horn: An electron microscope study in the rat'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 223
year: '1997'
...
---
_id: '2576'
abstract:
- lang: eng
text: Primary afferent neurons containing substance P (SP) are apparently implicated
in the transmission of noxious information from the periphery to the central nervous
system, and SP released from primary afferent neurons acts on second-order neurons
with the SP receptor (SPR). In the rat, nociceptive information reached the hypothalamus
not only through indirect pathways but also directly through trigeminohypothalamic
and spinohypothalamic pathways. Thus, in the present study, the distribution pattern
of trigeminohypothalamic and spinohypothalamic tract neurons showing SPR-like
immunoreactivity (SPR-LI) was examined in the rat by a retrograde tract-tracing
method combined with immunofluorescence histochemistry for SPR. A substantial
number of trigeminal and spinal neurons with SPR-LI were retrogradely labeled
with Fluore-Gold (FG) injected into the hypothalamic regions. These neurons were
distributed mainly in lamina I of the medullary and spinal dorsal horns, lateral
spinal nucleus, regions around the central canal of the spinal cord, and the lateral
aspect of the deep part of the spinal dorsal horn. A number of SPR-LI neurons
in the spinal parasympathetic nucleus were labeled with FG injected into the area
around the paraventricular hypothalamic nucleus. Some SPR-LI neurons in the lateral
spinal nucleus and the lateral aspect of the deep part of the spinal dorsal horn
were also labeled with FG injected into the septal region. On the basis of the
distribution areas of SPR-LI trigeminal and spinal neurons projecting to the hypothalamic
and septal regions, it is likely that these neurons are involved in the transmission
of somatic and/or visceral noxious information.
acknowledgement: This study was supported by grants 08279106 and 08458245 from the
Ministry of Education, Science, Sportsand Culture of Japan. We are grateful for
the photographic help of Mr. Akira Uesugi and the support of Dr. Kajitaro Morita
in Morita Clinic of Internal Medicine and Pediatrics, Kadoma, Osaka, Japan. We also
express our gratitude for the support of Drs. Satoru Fukuchi, Ritsu Hayashi,Sohzaburo
Hayashi, Mizuho Katsurada, Hitoski Kawai,Yutaka Kitani, Toshihiko Kuroda, Keiko
Kumagai, Hiroshi Matsubara, Hiroshi Matsushima, Chisato Minakuchi,Gonpei Niwa, Hajime
Oda, Mashiko Ohbayashi, Seiichi Ohbayashi, Hiroyasu Ohtsuka, Shigeo Tamaki, EizoWatanabe,
Kazuo Yoshino, and Toshiaki Yoshino.
article_processing_charge: No
article_type: original
author:
- first_name: Jin
full_name: Li, Jin
last_name: Li
- first_name: Takeshi
full_name: Kaneko, Takeshi
last_name: Kaneko
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Li J, Kaneko T, Shigemoto R, Mizuno N. Distribution of trigeminohypothalamic
and spinohypothalamic tract neurons displaying substance P receptor-like immunoreactivity
in the rat. Journal of Comparative Neurology. 1997;378(4):508-521. doi:10.1002/(SICI)1096-9861(19970224)378:4<508::AID-CNE6>3.0.CO;2-6
apa: Li, J., Kaneko, T., Shigemoto, R., & Mizuno, N. (1997). Distribution of
trigeminohypothalamic and spinohypothalamic tract neurons displaying substance
P receptor-like immunoreactivity in the rat. Journal of Comparative Neurology.
Wiley-Blackwell. https://doi.org/10.1002/(SICI)1096-9861(19970224)378:4<508::AID-CNE6>3.0.CO;2-6
chicago: Li, Jin, Takeshi Kaneko, Ryuichi Shigemoto, and Noboru Mizuno. “Distribution
of Trigeminohypothalamic and Spinohypothalamic Tract Neurons Displaying Substance
P Receptor-like Immunoreactivity in the Rat.” Journal of Comparative Neurology.
Wiley-Blackwell, 1997. https://doi.org/10.1002/(SICI)1096-9861(19970224)378:4<508::AID-CNE6>3.0.CO;2-6.
ieee: J. Li, T. Kaneko, R. Shigemoto, and N. Mizuno, “Distribution of trigeminohypothalamic
and spinohypothalamic tract neurons displaying substance P receptor-like immunoreactivity
in the rat,” Journal of Comparative Neurology, vol. 378, no. 4. Wiley-Blackwell,
pp. 508–521, 1997.
ista: Li J, Kaneko T, Shigemoto R, Mizuno N. 1997. Distribution of trigeminohypothalamic
and spinohypothalamic tract neurons displaying substance P receptor-like immunoreactivity
in the rat. Journal of Comparative Neurology. 378(4), 508–521.
mla: Li, Jin, et al. “Distribution of Trigeminohypothalamic and Spinohypothalamic
Tract Neurons Displaying Substance P Receptor-like Immunoreactivity in the Rat.”
Journal of Comparative Neurology, vol. 378, no. 4, Wiley-Blackwell, 1997,
pp. 508–21, doi:10.1002/(SICI)1096-9861(19970224)378:4<508::AID-CNE6>3.0.CO;2-6.
short: J. Li, T. Kaneko, R. Shigemoto, N. Mizuno, Journal of Comparative Neurology
378 (1997) 508–521.
date_created: 2018-12-11T11:58:28Z
date_published: 1997-02-24T00:00:00Z
date_updated: 2022-08-22T13:34:53Z
day: '24'
doi: 10.1002/(SICI)1096-9861(19970224)378:4<508::AID-CNE6>3.0.CO;2-6
extern: '1'
external_id:
pmid:
- '9034907'
intvolume: ' 378'
issue: '4'
language:
- iso: eng
month: '02'
oa_version: None
page: 508 - 521
pmid: 1
publication: Journal of Comparative Neurology
publication_identifier:
issn:
- 0021-9967
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4323'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Distribution of trigeminohypothalamic and spinohypothalamic tract neurons displaying
substance P receptor-like immunoreactivity in the rat
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 378
year: '1997'
...
---
_id: '2577'
abstract:
- lang: eng
text: The cloned cDNA for rat prostacyclin synthase was found to contain a 1503-bp
open reading frame which encoded a 501-amino acid protein sharing 84% identity
with the human enzyme. RNA blot analysis revealed that the rat prostacyclin synthase
mRNA, as a single species of 2.1 kb, is expressed abundantly in the aorta and
uterus. High levels of expression were also observed in the stomach, lung, heart,
testis, liver, and skeletal muscle. Low but significant expression was also seen
in the brain and kidney. Furthermore, the regional distribution and cellular localization
of prostacyclin synthase mRNA were examined by in situ hybridization analysis
of rat tissue sections. The definitive signals for the mRNA were localized in
smooth muscle cells of the arteries, bronchi and uterus, and in the cells of the
fibrous tunic surrounding the seminiferous tubules, which are characterized as
smooth muscle cells. Besides smooth muscle cells, signal were also detected in
the fibroblasts of the heart myocardium, lung parenchyma cells and kidney inner
medulla tubules and interstitial cells.
article_processing_charge: No
article_type: original
author:
- first_name: Yoshinori
full_name: Tone, Yoshinori
last_name: Tone
- first_name: Hiroyasu
full_name: Inoue, Hiroyasu
last_name: Inoue
- first_name: Shuntaro
full_name: Hara, Shuntaro
last_name: Hara
- first_name: Chieko
full_name: Yokoyama, Chieko
last_name: Yokoyama
- first_name: Toshihisa
full_name: Hatae, Toshihisa
last_name: Hatae
- first_name: Hiroji
full_name: Oida, Hiroji
last_name: Oida
- first_name: Shuh
full_name: Narumiya, Shuh
last_name: Narumiya
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Susumu
full_name: Yukawa, Susumu
last_name: Yukawa
- first_name: Tadashi
full_name: Tanabe, Tadashi
last_name: Tanabe
citation:
ama: Tone Y, Inoue H, Hara S, et al. The regional distribution and cellular localization
of mRNA encoding rat prostacyclin synthase. European Journal of Cell Biology.
1997;72(3):268-277.
apa: Tone, Y., Inoue, H., Hara, S., Yokoyama, C., Hatae, T., Oida, H., … Tanabe,
T. (1997). The regional distribution and cellular localization of mRNA encoding
rat prostacyclin synthase. European Journal of Cell Biology. Elsevier.
chicago: Tone, Yoshinori, Hiroyasu Inoue, Shuntaro Hara, Chieko Yokoyama, Toshihisa
Hatae, Hiroji Oida, Shuh Narumiya, Ryuichi Shigemoto, Susumu Yukawa, and Tadashi
Tanabe. “The Regional Distribution and Cellular Localization of MRNA Encoding
Rat Prostacyclin Synthase.” European Journal of Cell Biology. Elsevier,
1997.
ieee: Y. Tone et al., “The regional distribution and cellular localization
of mRNA encoding rat prostacyclin synthase,” European Journal of Cell Biology,
vol. 72, no. 3. Elsevier, pp. 268–277, 1997.
ista: Tone Y, Inoue H, Hara S, Yokoyama C, Hatae T, Oida H, Narumiya S, Shigemoto
R, Yukawa S, Tanabe T. 1997. The regional distribution and cellular localization
of mRNA encoding rat prostacyclin synthase. European Journal of Cell Biology.
72(3), 268–277.
mla: Tone, Yoshinori, et al. “The Regional Distribution and Cellular Localization
of MRNA Encoding Rat Prostacyclin Synthase.” European Journal of Cell Biology,
vol. 72, no. 3, Elsevier, 1997, pp. 268–77.
short: Y. Tone, H. Inoue, S. Hara, C. Yokoyama, T. Hatae, H. Oida, S. Narumiya,
R. Shigemoto, S. Yukawa, T. Tanabe, European Journal of Cell Biology 72 (1997)
268–277.
date_created: 2018-12-11T11:58:29Z
date_published: 1997-03-01T00:00:00Z
date_updated: 2022-08-22T12:50:04Z
day: '01'
extern: '1'
external_id:
pmid:
- '9084989 '
intvolume: ' 72'
issue: '3'
language:
- iso: eng
month: '03'
oa_version: None
page: 268 - 277
pmid: 1
publication: European Journal of Cell Biology
publication_identifier:
issn:
- 0171-9335
publication_status: published
publisher: Elsevier
publist_id: '4321'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The regional distribution and cellular localization of mRNA encoding rat prostacyclin
synthase
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 72
year: '1997'
...
---
_id: '2578'
abstract:
- lang: eng
text: The distribution of immunoreactivity to the neurokinin3 receptor (NK3R) was
examined in segments C7, T11-12, L1-2, and L4-6 of the rat spinal cord. NK3R immunoreactivity
was visualized by using two antisera generated against sequences of amino acids
contained in the C-terminal region of the NK3R. NK3R-immunoreactive cells were
numerous in the substantia gelatinosa of all spinal segments examined as well
as the dorsal commissural nucleus of spinal segments L1-2. Isolated, immunoreactive
cells were scattered throughout other regions of the spinal cord. The relationship
of NK3R-immunoreactivity with neurons was demonstrated by colocalization with
microtubule associated protein 2-immunoreactivity in individual cells. Within
neurons, NK3R- immunoreactivity was associated predominately with the plasma membrane
of cell bodies and dendrites. Within the substantia gelatinosa, 86% of nitric
oxide synthase (NOS)-immunoreactive neurons were also NK3R-immunoreactive. Although
NOS-immunoreactive neurons were found throughout all other regions of the spinal
cord in the segments examined, these were not NK3R- immunoreactive. When preganglionic
sympathetic neurons in spinal segments T11-12 and L1-2 were visualized by intraperitoneal
injection of Fluorogold, less than 1% of the Fluorogold-labeled neurons were also
immunoreactive for NK3R. The large number of NK3R-immunoreactive neurons in the
substantia gelatinosa suggests that some effects of tachykinins an somatosensation
may be mediated by NK3R.
acknowledgement: The authors are grateful to Dr. Colin Anderson fordiscussions of
the organization of spinal autonomic nuclei.V.S.S. was a visiting research fellow
in the Department ofAnatomy and Cell Biology, University of Melbourne.
article_processing_charge: No
article_type: original
author:
- first_name: Virginia
full_name: Seybold, Virginia
last_name: Seybold
- first_name: Ivica
full_name: Grković, Ivica
last_name: Grković
- first_name: Andrea
full_name: Portbury, Andrea
last_name: Portbury
- first_name: Yu
full_name: Ding, Yu
last_name: Ding
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
- first_name: John
full_name: Furness, John
last_name: Furness
- first_name: Bridget
full_name: Southwell, Bridget
last_name: Southwell
citation:
ama: Seybold V, Grković I, Portbury A, et al. Relationship of NK3 receptor-immunoreactivity
to subpopulations of neurons in rat spinal cord. Journal of Comparative Neurology.
1997;381(4):439-448. doi:10.1002/(SICI)1096-9861(19970519)381:4<439::AID-CNE4>3.0.CO;2-3
apa: Seybold, V., Grković, I., Portbury, A., Ding, Y., Shigemoto, R., Mizuno, N.,
… Southwell, B. (1997). Relationship of NK3 receptor-immunoreactivity to subpopulations
of neurons in rat spinal cord. Journal of Comparative Neurology. Wiley-Blackwell.
https://doi.org/10.1002/(SICI)1096-9861(19970519)381:4<439::AID-CNE4>3.0.CO;2-3
chicago: Seybold, Virginia, Ivica Grković, Andrea Portbury, Yu Ding, Ryuichi Shigemoto,
Noboru Mizuno, John Furness, and Bridget Southwell. “Relationship of NK3 Receptor-Immunoreactivity
to Subpopulations of Neurons in Rat Spinal Cord.” Journal of Comparative Neurology.
Wiley-Blackwell, 1997. https://doi.org/10.1002/(SICI)1096-9861(19970519)381:4<439::AID-CNE4>3.0.CO;2-3.
ieee: V. Seybold et al., “Relationship of NK3 receptor-immunoreactivity to
subpopulations of neurons in rat spinal cord,” Journal of Comparative Neurology,
vol. 381, no. 4. Wiley-Blackwell, pp. 439–448, 1997.
ista: Seybold V, Grković I, Portbury A, Ding Y, Shigemoto R, Mizuno N, Furness J,
Southwell B. 1997. Relationship of NK3 receptor-immunoreactivity to subpopulations
of neurons in rat spinal cord. Journal of Comparative Neurology. 381(4), 439–448.
mla: Seybold, Virginia, et al. “Relationship of NK3 Receptor-Immunoreactivity to
Subpopulations of Neurons in Rat Spinal Cord.” Journal of Comparative Neurology,
vol. 381, no. 4, Wiley-Blackwell, 1997, pp. 439–48, doi:10.1002/(SICI)1096-9861(19970519)381:4<439::AID-CNE4>3.0.CO;2-3.
short: V. Seybold, I. Grković, A. Portbury, Y. Ding, R. Shigemoto, N. Mizuno, J.
Furness, B. Southwell, Journal of Comparative Neurology 381 (1997) 439–448.
date_created: 2018-12-11T11:58:29Z
date_published: 1997-05-19T00:00:00Z
date_updated: 2022-08-22T12:27:14Z
day: '19'
doi: 10.1002/(SICI)1096-9861(19970519)381:4<439::AID-CNE4>3.0.CO;2-3
extern: '1'
external_id:
pmid:
- '9136801 '
intvolume: ' 381'
issue: '4'
language:
- iso: eng
month: '05'
oa_version: None
page: 439 - 448
pmid: 1
publication: Journal of Comparative Neurology
publication_identifier:
issn:
- 0021-9967
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4320'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Relationship of NK3 receptor-immunoreactivity to subpopulations of neurons
in rat spinal cord
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 381
year: '1997'
...
---
_id: '2579'
abstract:
- lang: eng
text: The localisation of the neurokinin 3 receptor (NK3r) in the rat gastrointestinal
tract has been studied by using a polyclonal antiserum against the C-terminal
portion (amino acids 388-452) of the rat NK3r. In the oesophagus, immunoreactivity
for the NK3r was found on smooth muscle cells of the muscularis mucosae. NK3r
immunoreactivity was not present on muscle cells of other regions. Nerve cell
bodies immunoreactive for NK3r were seen in the myenteric and submucous plexuses
of the small and large intestine, but not in the stomach or oesophagus. Immunoreactivity
was largely confined to nerve cell surfaces. The reaction product was on the cell
soma and initial parts of axons. Reactivity was not seen on nerve terminals. Immunoreactive
nerve cells had Dogiel Type II morphology. Patterns of co-localisation of NK3r
and immunoreactivity for other markers were examined in the ileum, to provide
a basis from which to deduce the functional identity of NK3r-immunoreactive nerve
cells. Most of the NK3r-immunoreactive nerve cells were also immunoreactive for
the calcium-binding proteins, calretinin and calbindin, and all were immunoreactive
for the NK1 receptor (NK1r). Nerve cells that were immunoreactive for nitric oxide
synthase were not immunoreactive for either NK3r or NK1r. The projections of the
calbindin and calretinin neurons were determined by nerve lesion studies. Their
morphology, projections to the mucosa and other ganglia and immunoreactivity for
the calcium-binding proteins suggest that the NK3r-immunoreactive neurons are
intrinsic sensory neurons.
acknowledgement: This work was supported by grants from the National Health and Medical
Research Council of Australia and the National Science Foundation of the Peoples
Republic of China. Patricia Mann is a holder of a Gastroenterological Society of
Australia Post-Graduate Scholarship.
article_processing_charge: No
article_type: original
author:
- first_name: Patricia
full_name: Mann, Patricia
last_name: Mann
- first_name: Bridget
full_name: Southwell, Bridget
last_name: Southwell
- first_name: Yu
full_name: Ding, Yu
last_name: Ding
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
- first_name: John
full_name: Furness, John
last_name: Furness
citation:
ama: Mann P, Southwell B, Ding Y, Shigemoto R, Mizuno N, Furness J. Localisation
of neurokinin 3 (NK3) receptor immunoreactivity in the rat gastrointestinal tract.
Cell and Tissue Research. 1997;289(1):1-9. doi:10.1007/s004410050846
apa: Mann, P., Southwell, B., Ding, Y., Shigemoto, R., Mizuno, N., & Furness,
J. (1997). Localisation of neurokinin 3 (NK3) receptor immunoreactivity in the
rat gastrointestinal tract. Cell and Tissue Research. Springer. https://doi.org/10.1007/s004410050846
chicago: Mann, Patricia, Bridget Southwell, Yu Ding, Ryuichi Shigemoto, Noboru Mizuno,
and John Furness. “Localisation of Neurokinin 3 (NK3) Receptor Immunoreactivity
in the Rat Gastrointestinal Tract.” Cell and Tissue Research. Springer,
1997. https://doi.org/10.1007/s004410050846.
ieee: P. Mann, B. Southwell, Y. Ding, R. Shigemoto, N. Mizuno, and J. Furness, “Localisation
of neurokinin 3 (NK3) receptor immunoreactivity in the rat gastrointestinal tract,”
Cell and Tissue Research, vol. 289, no. 1. Springer, pp. 1–9, 1997.
ista: Mann P, Southwell B, Ding Y, Shigemoto R, Mizuno N, Furness J. 1997. Localisation
of neurokinin 3 (NK3) receptor immunoreactivity in the rat gastrointestinal tract.
Cell and Tissue Research. 289(1), 1–9.
mla: Mann, Patricia, et al. “Localisation of Neurokinin 3 (NK3) Receptor Immunoreactivity
in the Rat Gastrointestinal Tract.” Cell and Tissue Research, vol. 289,
no. 1, Springer, 1997, pp. 1–9, doi:10.1007/s004410050846.
short: P. Mann, B. Southwell, Y. Ding, R. Shigemoto, N. Mizuno, J. Furness, Cell
and Tissue Research 289 (1997) 1–9.
date_created: 2018-12-11T11:58:29Z
date_published: 1997-06-01T00:00:00Z
date_updated: 2022-08-22T12:19:10Z
day: '01'
doi: 10.1007/s004410050846
extern: '1'
external_id:
pmid:
- '9182595'
intvolume: ' 289'
issue: '1'
language:
- iso: eng
month: '06'
oa_version: None
page: 1 - 9
pmid: 1
publication: Cell and Tissue Research
publication_identifier:
issn:
- 0044-3794
publication_status: published
publisher: Springer
publist_id: '4319'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Localisation of neurokinin 3 (NK3) receptor immunoreactivity in the rat gastrointestinal
tract
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 289
year: '1997'
...
---
_id: '2580'
abstract:
- lang: eng
text: Two group I metabotropic glutamate receptor subtypes, mGluR1 and mGluR5, have
been reported to occur in highest concentration in an annulus surrounding the
edge of the postsynaptic membrane specialisation. In order to determine whether
such a distribution is uniform amongst postsynaptic mGluRs, their distribution
was compared quantitatively by a pre-embedding silver-intensified immunogold technique
at electron microscopic level in hippocampal pyramidal cells (mGluR5), cerebellar
Purkinje cells (mGluR1α) and Golgi cells (mGluR2). The results show that mGluR1α,
mGluR5 and mGluR2 each have a distinct distribution in relation to the glutamatergic
synaptic junctions. On dendritic spines, mGluRlα and mGluR5 showed the highest
receptor density in a perisynaptic annulus (defined as within 60 nm of the edge
of the synapse) followed by a decreasing extrasynaptic (60-900 nm) receptor level,
but the gradient of decrease and the proportion of the perisynaptic pool (mGluR1α,
~ 50%; vs mGluR5, ~ 25%) were different for the two receptors. The distributions
of mGluRlα and mGluR5 also differed significantly from simulated random distributions.
In contrast, mGluR2 was not closely associated with glutamatergic synapses in
the dendritic plasma membrane of cerebellar Golgi cells and its distribution relative
to synapses is not different from simulated random distribution in the membrane.
The somatic membrane, the axon and the synaptic boutons of the GABAergic Golgi
cells also contained immunoreactive mGluR2 that is not associated with synaptic
specialisations. In the hippocampal CA1 area the distribution of immunoparticles
for mGluR5 on individual spines was established using serial sections. The results
indicate that dendritic spines of pyramidal cells are heterogeneous with respect
to the ratio of perisynaptic to extrasynaptic mGluR5 pools and about half of the
immunopositive spines lack the perisynaptic pool. The quantitative comparison
of receptor distributions demonstrates that mGluRlα and mGluR5, but not mGluR2,
are highly compartmentalised in different plasma membrane domains. The unique
distribution of each mGluR subtype may reflect requirements for different transduction
and effector mechanisms between cell types and different domains of the same cell,
and suggests that the precise placement of receptors is a crucial factor contributing
to neuronal communication.
acknowledgement: The authors are grateful to Dr Tibor Szilagyi and Mr Laszlo Marton
for advice, helpful discussions, providing the simulations of receptor distribution
and the cylindrical approximation of dendritic surface (L.M.). The brain of a mGluR2
deficient mouse was kindly provided by Drs M. Yokoi and S. Nakanishi for testing
of the specificity of one of the antibodies. The authors also thank Dr Jeff McIlhinney
for critical comments and Dr Zoltan Nusser for help with the statistics, for helpful
discussion during the project and for his comments on an earlier version of the
manuscript. The technical assistance of Ms Zahida Ahmad and the photographic assistance
of Mr Frank Kennedy, Mr Paul Jays and Mr Akira Uesugi are acknowledged. This work
was partly supported by grants from the Japan Society for the Promotion of Science,
the British Council and the Royal Society.
article_processing_charge: No
article_type: original
author:
- first_name: Rafael
full_name: Luján, Rafael
last_name: Luján
- first_name: John
full_name: Roberts, John
last_name: Roberts
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Péter
full_name: Somogyi, Péter
last_name: Somogyi
citation:
ama: Luján R, Roberts J, Shigemoto R, Ohishi H, Somogyi P. Differential plasma membrane
distribution of metabotropic glutamate receptors mGluR1α, mGluR2 and mGluR5, relative
to neurotransmitter release sites. Journal of Chemical Neuroanatomy. 1997;13(4):219-241.
doi:10.1016/S0891-0618(97)00051-3
apa: Luján, R., Roberts, J., Shigemoto, R., Ohishi, H., & Somogyi, P. (1997).
Differential plasma membrane distribution of metabotropic glutamate receptors
mGluR1α, mGluR2 and mGluR5, relative to neurotransmitter release sites. Journal
of Chemical Neuroanatomy. Elsevier. https://doi.org/10.1016/S0891-0618(97)00051-3
chicago: Luján, Rafael, John Roberts, Ryuichi Shigemoto, Hitoshi Ohishi, and Péter
Somogyi. “Differential Plasma Membrane Distribution of Metabotropic Glutamate
Receptors MGluR1α, MGluR2 and MGluR5, Relative to Neurotransmitter Release Sites.”
Journal of Chemical Neuroanatomy. Elsevier, 1997. https://doi.org/10.1016/S0891-0618(97)00051-3.
ieee: R. Luján, J. Roberts, R. Shigemoto, H. Ohishi, and P. Somogyi, “Differential
plasma membrane distribution of metabotropic glutamate receptors mGluR1α, mGluR2
and mGluR5, relative to neurotransmitter release sites,” Journal of Chemical
Neuroanatomy, vol. 13, no. 4. Elsevier, pp. 219–241, 1997.
ista: Luján R, Roberts J, Shigemoto R, Ohishi H, Somogyi P. 1997. Differential plasma
membrane distribution of metabotropic glutamate receptors mGluR1α, mGluR2 and
mGluR5, relative to neurotransmitter release sites. Journal of Chemical Neuroanatomy.
13(4), 219–241.
mla: Luján, Rafael, et al. “Differential Plasma Membrane Distribution of Metabotropic
Glutamate Receptors MGluR1α, MGluR2 and MGluR5, Relative to Neurotransmitter Release
Sites.” Journal of Chemical Neuroanatomy, vol. 13, no. 4, Elsevier, 1997,
pp. 219–41, doi:10.1016/S0891-0618(97)00051-3.
short: R. Luján, J. Roberts, R. Shigemoto, H. Ohishi, P. Somogyi, Journal of Chemical
Neuroanatomy 13 (1997) 219–241.
date_created: 2018-12-11T11:58:30Z
date_published: 1997-10-04T00:00:00Z
date_updated: 2022-08-22T12:12:03Z
day: '04'
doi: 10.1016/S0891-0618(97)00051-3
extern: '1'
external_id:
pmid:
- '9412905'
intvolume: ' 13'
issue: '4'
language:
- iso: eng
month: '10'
oa_version: None
page: 219 - 241
pmid: 1
publication: Journal of Chemical Neuroanatomy
publication_identifier:
issn:
- 0891-0618
publication_status: published
publisher: Elsevier
publist_id: '4318'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Differential plasma membrane distribution of metabotropic glutamate receptors
mGluR1α, mGluR2 and mGluR5, relative to neurotransmitter release sites
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 13
year: '1997'
...
---
_id: '2581'
abstract:
- lang: eng
text: It is well known that striatonigral neurons produce substance P (SP); however,
no SP receptor (SPR) has so far been found in the substantia nigra. On the other
hand, a previous study in the rat striatum indicated that SPR was expressed only
in cholinergic or somatostatinergic intrinsic neurons (Kaneko et al. [1993] Brain
Res. 631:297-303). Thus, it was assumed that SP produced by striatenigral neurons
might be released through their intrastriatal axon collaterals to act upon intrinsic
neurons in the striatum. To confirm this assumption, the distribution of axon
collaterals of striatonigral neurons was examined in the striatum of the rat.
The experiments were performed on brain slices by combining retrograde labeling
with tetramethylrhodamine-dextran amine, electrophysiological recording, intracellular
staining with biocytin, and immunocytochemistry for SPR. The distribution of axons
of cholinergic striatal neurons (a group of SP-negative intrinsic striatal neurons)
was also examined. It was observed that 16% of varicosities of intrastriatal axon
collaterals of striatonigral neurons, as well as 6% of axonal varicosities of
cholinergic neurons, were in close apposition to dendrites and cell bodies of
SPB-immunoreactive striatal neurons. Since SPR-immunoreactive striatal neurons
constituted only 2.7% of the total population of striatal neurons (Kaneko et al.
[1993] Brain Res. 631:297-303), it appeared that axonal varicosities of striatonigral
neurons were preferentially apposed to SPR-immunoreactive striatal neurons and
that the varicosities in close apposition to SPR-immunoreactive neurons were derived
more frequently from striatonigral neurons than from cholinergic interneurons.
Confocal laser scanning microscopy indicated that axonal varicosities in close
apposition to SPR-immunoreactive cells showed synaptophysin immunoreactivity,
a marker of synaptic vesicles. In intrastriatal axons of striatonigral neurons,
it was further revealed from electron microscopy that axonal varicosities in close
apposition to SPR- immunoreactive dendrites, at least a part of them, made synapses
of the symmetric type. Striatonigral neurons might release SP preferentially around
cholinergic or somatostatinergic intrinsic neurons to regulate them through SP-SPR
interactions.
acknowledgement: The authors are grateful for the photographic help of Mr.A. Uesugi.
We also express our gratitude for the support ofDrs. Satoru Fukuchi, Ritsu Hayashi,
Sohzaburo Hayashi,Mizuho Katsurada, Hitoshi Kawai, Yutaka Kitani, Toshi-hiko Kuroda,
Keiko Kumagai, Hiroshi Matsubara, HiroshiMatsushima, Chisato Minakuchi, Gonpei Niwa, HajimeOda,
Masahiko Ohbayashi, Sei-ichi Ohbayashi, Hiroyasu Ohtsuka, Shigeo Tamaki, Eizo Watanabe,
Kazuo Yoshino,and Toshiaki Yoshino.
article_processing_charge: No
article_type: original
author:
- first_name: Teffy
full_name: Lee, Teffy
last_name: Lee
- first_name: Takeshi
full_name: Kaneko, Takeshi
last_name: Kaneko
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Sakashi
full_name: Nomura, Sakashi
last_name: Nomura
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Lee T, Kaneko T, Shigemoto R, Nomura S, Mizuno N. Collateral projections from
striatonigral neurons to substance P receptor-expressing intrinsic neurons in
the striatum of the rat. Journal of Comparative Neurology. 1997;388(2):250-264.
doi:10.1002/(SICI)1096-9861(19971117)388:2<250::AID-CNE5>3.0.CO;2-0
apa: Lee, T., Kaneko, T., Shigemoto, R., Nomura, S., & Mizuno, N. (1997). Collateral
projections from striatonigral neurons to substance P receptor-expressing intrinsic
neurons in the striatum of the rat. Journal of Comparative Neurology. Wiley-Blackwell.
https://doi.org/10.1002/(SICI)1096-9861(19971117)388:2<250::AID-CNE5>3.0.CO;2-0
chicago: Lee, Teffy, Takeshi Kaneko, Ryuichi Shigemoto, Sakashi Nomura, and Noboru
Mizuno. “Collateral Projections from Striatonigral Neurons to Substance P Receptor-Expressing
Intrinsic Neurons in the Striatum of the Rat.” Journal of Comparative Neurology.
Wiley-Blackwell, 1997. https://doi.org/10.1002/(SICI)1096-9861(19971117)388:2<250::AID-CNE5>3.0.CO;2-0.
ieee: T. Lee, T. Kaneko, R. Shigemoto, S. Nomura, and N. Mizuno, “Collateral projections
from striatonigral neurons to substance P receptor-expressing intrinsic neurons
in the striatum of the rat,” Journal of Comparative Neurology, vol. 388,
no. 2. Wiley-Blackwell, pp. 250–264, 1997.
ista: Lee T, Kaneko T, Shigemoto R, Nomura S, Mizuno N. 1997. Collateral projections
from striatonigral neurons to substance P receptor-expressing intrinsic neurons
in the striatum of the rat. Journal of Comparative Neurology. 388(2), 250–264.
mla: Lee, Teffy, et al. “Collateral Projections from Striatonigral Neurons to Substance
P Receptor-Expressing Intrinsic Neurons in the Striatum of the Rat.” Journal
of Comparative Neurology, vol. 388, no. 2, Wiley-Blackwell, 1997, pp. 250–64,
doi:10.1002/(SICI)1096-9861(19971117)388:2<250::AID-CNE5>3.0.CO;2-0.
short: T. Lee, T. Kaneko, R. Shigemoto, S. Nomura, N. Mizuno, Journal of Comparative
Neurology 388 (1997) 250–264.
date_created: 2018-12-11T11:58:30Z
date_published: 1997-11-17T00:00:00Z
date_updated: 2022-08-22T10:03:38Z
day: '17'
doi: 10.1002/(SICI)1096-9861(19971117)388:2<250::AID-CNE5>3.0.CO;2-0
extern: '1'
external_id:
pmid:
- '9368840'
intvolume: ' 388'
issue: '2'
language:
- iso: eng
month: '11'
oa_version: None
page: 250 - 264
pmid: 1
publication: Journal of Comparative Neurology
publication_identifier:
issn:
- 0021-9967
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4316'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Collateral projections from striatonigral neurons to substance P receptor-expressing
intrinsic neurons in the striatum of the rat
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 388
year: '1997'
...
---
_id: '2582'
abstract:
- lang: eng
text: 'Neurotransmission in the hippocampus is modulated variously through presynaptic
metabotropic glutamate receptors (mGluRs). To establish the precise localization
of presynaptic mGluRs in the rat hippocampus, we used subtype-specific antibodies
for eight mGluRs (mGluR1-mGluR8) for immunohistochemistry combined with lesioning
of the three major hippocampal pathways: the perforant path, mossy fiber, and
Schaffer collateral. Immunoreactivity for group II (mGluR2) and group III (mGluR4a,
mGluR7a, mGluR7b, and mGluR8) mGluRs was predominantly localized to presynaptic
elements, whereas that for group I mGluRs (mGluR1 and mGluR5) was localized to
postsynaptic elements. The medial perforant path was strongly immunoreactive for
mGluR2 and mGluR7a throughout the hippocampus, and the lateral perforant path
was prominently immunoreactive for mGluR8 in the dentate gyrus and CA3 area. The
messy fiber was labeled for mGluR2, mGluR7a, and mGluR7b, whereas the Schaffer
collateral was labeled only for mGluR7a. Electron microscopy further revealed
the spatial segregation of group II and group III mGluRs within presynaptic elements.
Immunolabeling for the group III receptors was predominantly observed in presynaptic
active zones of asymmetrical and symmetrical synapses, whereas that for the group
II receptor (mGluR2) was found in preterminal rather than terminal portions of
axons. Target cell-specific segregation of receptors, first reported for mGluR7a
(Shigemoto et al., 1996), was also apparent for the other group III mGluRs, suggesting
that transmitter release is differentially regulated by 2-amino- 4-phosphonobutyrate-sensitive
mGluRs in individual synapses on single axons according to the identity of postsynaptic
neurons.'
acknowledgement: This work was supported by research grants from the Inamori Foundation
and the Ministry of Education, Science, Sports and Culture of Japan. We thank Peter
Somogyi for helpful discussion, David Roberts for technical assistance, and Akira
Uesugi for photographic assistance. We are grateful to Atsu Aiba, David Hampson,
John Roder, and Herman van der Putten for providing us with mGluR1-, mGluR4-, mGluR5-,
and mGluR7-deficient mice, respectively, and to Corrado Corti and Francesco Ferraguti
for sharing rat mGluR8 cDNA and unpublished results.
article_processing_charge: No
article_type: original
author:
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Ayae
full_name: Kinoshita, Ayae
last_name: Kinoshita
- first_name: Eiki
full_name: Wada, Eiki
last_name: Wada
- first_name: Sakashi
full_name: Nomura, Sakashi
last_name: Nomura
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Masahiko
full_name: Takada, Masahiko
last_name: Takada
- first_name: Peter
full_name: Flor, Peter
last_name: Flor
- first_name: Akio
full_name: Neki, Akio
last_name: Neki
- first_name: Takaaki
full_name: Abe, Takaaki
last_name: Abe
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Shigemoto R, Kinoshita A, Wada E, et al. Differential presynaptic localization
of metabotropic glutamate receptor subtypes in the rat hippocampus. Journal
of Neuroscience. 1997;17(19):7503-7522. doi:10.1523/JNEUROSCI.17-19-07503.1997
apa: Shigemoto, R., Kinoshita, A., Wada, E., Nomura, S., Ohishi, H., Takada, M.,
… Mizuno, N. (1997). Differential presynaptic localization of metabotropic glutamate
receptor subtypes in the rat hippocampus. Journal of Neuroscience. Society
for Neuroscience. https://doi.org/10.1523/JNEUROSCI.17-19-07503.1997
chicago: Shigemoto, Ryuichi, Ayae Kinoshita, Eiki Wada, Sakashi Nomura, Hitoshi
Ohishi, Masahiko Takada, Peter Flor, et al. “Differential Presynaptic Localization
of Metabotropic Glutamate Receptor Subtypes in the Rat Hippocampus.” Journal
of Neuroscience. Society for Neuroscience, 1997. https://doi.org/10.1523/JNEUROSCI.17-19-07503.1997.
ieee: R. Shigemoto et al., “Differential presynaptic localization of metabotropic
glutamate receptor subtypes in the rat hippocampus,” Journal of Neuroscience,
vol. 17, no. 19. Society for Neuroscience, pp. 7503–7522, 1997.
ista: Shigemoto R, Kinoshita A, Wada E, Nomura S, Ohishi H, Takada M, Flor P, Neki
A, Abe T, Nakanishi S, Mizuno N. 1997. Differential presynaptic localization of
metabotropic glutamate receptor subtypes in the rat hippocampus. Journal of Neuroscience.
17(19), 7503–7522.
mla: Shigemoto, Ryuichi, et al. “Differential Presynaptic Localization of Metabotropic
Glutamate Receptor Subtypes in the Rat Hippocampus.” Journal of Neuroscience,
vol. 17, no. 19, Society for Neuroscience, 1997, pp. 7503–22, doi:10.1523/JNEUROSCI.17-19-07503.1997.
short: R. Shigemoto, A. Kinoshita, E. Wada, S. Nomura, H. Ohishi, M. Takada, P.
Flor, A. Neki, T. Abe, S. Nakanishi, N. Mizuno, Journal of Neuroscience 17 (1997)
7503–7522.
date_created: 2018-12-11T11:58:30Z
date_published: 1997-10-01T00:00:00Z
date_updated: 2022-08-22T11:32:01Z
day: '01'
doi: 10.1523/JNEUROSCI.17-19-07503.1997
extern: '1'
external_id:
pmid:
- '9295396'
intvolume: ' 17'
issue: '19'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6573434/
month: '10'
oa: 1
oa_version: Published Version
page: 7503 - 7522
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '4317'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Differential presynaptic localization of metabotropic glutamate receptor subtypes
in the rat hippocampus
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 17
year: '1997'
...
---
_id: '2727'
abstract:
- lang: eng
text: Diamagnetism of the magnetic Schrödinger operator and paramagnetism of the
Pauli operator are rigorously proven for nonhomogeneous magnetic fields in the
large field, in the large temperature and in the semiclassical asymptotic regimes.
New counterexamples are presented which show that neither dia-nor paramagnetism
is true in a robust sense (without asymptotics). In particular, we demonstrate
that the recent diamagnetic comparison result by Loss and Thaller [M. Loss and
B. Thaller, Commun. Math. Phys. (submitted)] is essentially the best one can hope
for.
acknowledgement: This work was started in the stimulating environment and with the
financial support of the PCMI Summer School on Probability Theory ~IAS Princeton,
1996!. The author also expresses his gratitude to M. Loss and B. Thaller for explaining
their paper to him.
article_processing_charge: No
article_type: original
author:
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
citation:
ama: Erdös L. Dia- and paramagnetism for nonhomogeneous magnetic fields. Journal
of Mathematical Physics. 1997;38(3):1289-1317. doi:10.1063/1.531909
apa: Erdös, L. (1997). Dia- and paramagnetism for nonhomogeneous magnetic fields.
Journal of Mathematical Physics. American Institute of Physics. https://doi.org/10.1063/1.531909
chicago: Erdös, László. “Dia- and Paramagnetism for Nonhomogeneous Magnetic Fields.”
Journal of Mathematical Physics. American Institute of Physics, 1997. https://doi.org/10.1063/1.531909.
ieee: L. Erdös, “Dia- and paramagnetism for nonhomogeneous magnetic fields,” Journal
of Mathematical Physics, vol. 38, no. 3. American Institute of Physics, pp.
1289–1317, 1997.
ista: Erdös L. 1997. Dia- and paramagnetism for nonhomogeneous magnetic fields.
Journal of Mathematical Physics. 38(3), 1289–1317.
mla: Erdös, László. “Dia- and Paramagnetism for Nonhomogeneous Magnetic Fields.”
Journal of Mathematical Physics, vol. 38, no. 3, American Institute of
Physics, 1997, pp. 1289–317, doi:10.1063/1.531909.
short: L. Erdös, Journal of Mathematical Physics 38 (1997) 1289–1317.
date_created: 2018-12-11T11:59:17Z
date_published: 1997-03-01T00:00:00Z
date_updated: 2022-08-22T09:48:50Z
day: '01'
doi: 10.1063/1.531909
extern: '1'
intvolume: ' 38'
issue: '3'
language:
- iso: eng
month: '03'
oa_version: None
page: 1289 - 1317
publication: Journal of Mathematical Physics
publication_identifier:
issn:
- 0022-2488
publication_status: published
publisher: American Institute of Physics
publist_id: '4165'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Dia- and paramagnetism for nonhomogeneous magnetic fields
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 38
year: '1997'
...
---
_id: '2729'
abstract:
- lang: eng
text: We give the leading order semiclassical asymptotics for the sum of the negative
eigenvalues of the Pauli operator (in dimension two and three) with a strong non-homogeneous
magnetic field. As in [LSY-II] for homogeneous field, this result can be used
to prove that the magnetic Thomas-Fermi theory gives the leading order ground
state energy of large atoms. We develop a new localization scheme well suited
to the anisotropic character of the strong magnetic field. We also use the basic
Lieb-Thirring estimate obtained in our companion paper [ES-I].
acknowledgement: L. E. gratefully acknowledges financial support from the Forschungsinstitut
fur Mathematik, ETH, Zurich, where this work was started. He is also grateful for
the hospitality and support of Aarhus University during his visits. The authors
wish to thank the referee for the careful reading of the manuscript and the many
helpful remarks and suggestions.
article_processing_charge: No
article_type: original
author:
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
- first_name: Jan
full_name: Solovej, Jan
last_name: Solovej
citation:
ama: Erdös L, Solovej J. Semiclassical eigenvalue estimates for the Pauli operator
with strong non-homogeneous magnetic fields, II. Leading order asymptotic estimates.
Communications in Mathematical Physics. 1997;188(3):599-656. doi:10.1007/s002200050181
apa: Erdös, L., & Solovej, J. (1997). Semiclassical eigenvalue estimates for
the Pauli operator with strong non-homogeneous magnetic fields, II. Leading order
asymptotic estimates. Communications in Mathematical Physics. Springer.
https://doi.org/10.1007/s002200050181
chicago: Erdös, László, and Jan Solovej. “Semiclassical Eigenvalue Estimates for
the Pauli Operator with Strong Non-Homogeneous Magnetic Fields, II. Leading Order
Asymptotic Estimates.” Communications in Mathematical Physics. Springer,
1997. https://doi.org/10.1007/s002200050181.
ieee: L. Erdös and J. Solovej, “Semiclassical eigenvalue estimates for the Pauli
operator with strong non-homogeneous magnetic fields, II. Leading order asymptotic
estimates,” Communications in Mathematical Physics, vol. 188, no. 3. Springer,
pp. 599–656, 1997.
ista: Erdös L, Solovej J. 1997. Semiclassical eigenvalue estimates for the Pauli
operator with strong non-homogeneous magnetic fields, II. Leading order asymptotic
estimates. Communications in Mathematical Physics. 188(3), 599–656.
mla: Erdös, László, and Jan Solovej. “Semiclassical Eigenvalue Estimates for the
Pauli Operator with Strong Non-Homogeneous Magnetic Fields, II. Leading Order
Asymptotic Estimates.” Communications in Mathematical Physics, vol. 188,
no. 3, Springer, 1997, pp. 599–656, doi:10.1007/s002200050181.
short: L. Erdös, J. Solovej, Communications in Mathematical Physics 188 (1997) 599–656.
date_created: 2018-12-11T11:59:18Z
date_published: 1997-10-01T00:00:00Z
date_updated: 2022-08-22T09:25:09Z
day: '01'
doi: 10.1007/s002200050181
extern: '1'
intvolume: ' 188'
issue: '3'
language:
- iso: eng
month: '10'
oa_version: None
page: 599 - 656
publication: Communications in Mathematical Physics
publication_identifier:
issn:
- 0010-3616
publication_status: published
publisher: Springer
publist_id: '4164'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Semiclassical eigenvalue estimates for the Pauli operator with strong non-homogeneous
magnetic fields, II. Leading order asymptotic estimates
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 188
year: '1997'
...
---
_id: '11666'
abstract:
- lang: eng
text: This article describes the Digital Continuous Profiling Infrastructure, a
sampling-based profiling system designed to run continuously on production systems.
The system supports multiprocessors, works on unmodified executables, and collects
profiles for entire systems, including user programs, shared libraries, and the
operating system kernel. Samples are collected at a high rate (over 5200 samples/sec.
per 333MHz processor), yet with low overhead (1–3% slowdown for most workloads).
Analysis tools supplied with the profiling system use the sample data to produce
a precise and accurate accounting, down to the level of pipeline stalls incurred
by individual instructions, of where time is bring spent. When instructions incur
stalls, the tools identify possible reasons, such as cache misses, branch mispredictions,
and functional unit contention. The fine-grained instruction-level analysis guides
users and automated optimizers to the causes of performance problems and provides
important insights for fixing them.
acknowledgement: We would like to thank Mike Burrows, Allan Heydon, Hal Murray, Sharon
Perl, and Sharon Smith for helpful comments that greatly improved the content and
presentation of this article; the anonymous referees for SOSP and TOCS also provided
numerous helpful comments. We would also like to thank Dawson Engler for initially
suggesting the use of interprocessor interrupts to avoid expensive synchronization
operations in the interrupt handler, Mitch Lichtenberg for his work on the Alpha/NT
version of our system and in general for his help and suggestions on the project,
and the developers of iprobe for supplying us with source code that helped us get
off the ground in building the early versions of our data collection system. Finally,
we would like to thank Gary Carleton and Bob Davies of Intel for answering our questions
about VTune and Marty Itzkowitz of SGI for answering our questions about SpeedShop.
article_processing_charge: No
article_type: original
author:
- first_name: Jennifer M.
full_name: Anderson, Jennifer M.
last_name: Anderson
- first_name: Lance M.
full_name: Berc, Lance M.
last_name: Berc
- first_name: Jeffrey
full_name: Dean, Jeffrey
last_name: Dean
- first_name: Sanjay
full_name: Ghemawat, Sanjay
last_name: Ghemawat
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Shun-Tak A.
full_name: Leung, Shun-Tak A.
last_name: Leung
- first_name: Richard L.
full_name: Sites, Richard L.
last_name: Sites
- first_name: Mark T.
full_name: Vandevoorde, Mark T.
last_name: Vandevoorde
- first_name: Carl A.
full_name: Waldspurger, Carl A.
last_name: Waldspurger
- first_name: William E.
full_name: Weihl, William E.
last_name: Weihl
citation:
ama: 'Anderson JM, Berc LM, Dean J, et al. Continuous profiling: Where have all
the cycles gone? ACM Transactions on Computer Systems. 1997;15(4):357-390.
doi:10.1145/265924.265925'
apa: 'Anderson, J. M., Berc, L. M., Dean, J., Ghemawat, S., Henzinger, M. H., Leung,
S.-T. A., … Weihl, W. E. (1997). Continuous profiling: Where have all the cycles
gone? ACM Transactions on Computer Systems. Association for Computing Machinery.
https://doi.org/10.1145/265924.265925'
chicago: 'Anderson, Jennifer M., Lance M. Berc, Jeffrey Dean, Sanjay Ghemawat, Monika
H Henzinger, Shun-Tak A. Leung, Richard L. Sites, Mark T. Vandevoorde, Carl A.
Waldspurger, and William E. Weihl. “Continuous Profiling: Where Have All the Cycles
Gone?” ACM Transactions on Computer Systems. Association for Computing
Machinery, 1997. https://doi.org/10.1145/265924.265925.'
ieee: 'J. M. Anderson et al., “Continuous profiling: Where have all the cycles
gone?,” ACM Transactions on Computer Systems, vol. 15, no. 4. Association
for Computing Machinery, pp. 357–390, 1997.'
ista: 'Anderson JM, Berc LM, Dean J, Ghemawat S, Henzinger MH, Leung S-TA, Sites
RL, Vandevoorde MT, Waldspurger CA, Weihl WE. 1997. Continuous profiling: Where
have all the cycles gone? ACM Transactions on Computer Systems. 15(4), 357–390.'
mla: 'Anderson, Jennifer M., et al. “Continuous Profiling: Where Have All the Cycles
Gone?” ACM Transactions on Computer Systems, vol. 15, no. 4, Association
for Computing Machinery, 1997, pp. 357–90, doi:10.1145/265924.265925.'
short: J.M. Anderson, L.M. Berc, J. Dean, S. Ghemawat, M.H. Henzinger, S.-T.A. Leung,
R.L. Sites, M.T. Vandevoorde, C.A. Waldspurger, W.E. Weihl, ACM Transactions on
Computer Systems 15 (1997) 357–390.
date_created: 2022-07-27T11:42:25Z
date_published: 1997-11-01T00:00:00Z
date_updated: 2022-09-09T12:00:13Z
day: '01'
doi: 10.1145/265924.265925
extern: '1'
intvolume: ' 15'
issue: '4'
language:
- iso: eng
month: '11'
oa_version: None
page: 357-390
publication: ACM Transactions on Computer Systems
publication_identifier:
eissn:
- 1557-7333
issn:
- 0734-2071
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Continuous profiling: Where have all the cycles gone?'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 15
year: '1997'
...
---
_id: '11765'
abstract:
- lang: eng
text: This paper presents insertions-only algorithms for maintaining the exact and/or
approximate size of the minimum edge cut and the minimum vertex cut of a graph.
The algorithms output the approximate or exact sizekin timeO(1) and a cut of sizekin
time linear in its size. For the minimum edge cut problem and for any 0 < ε ≤
1, the amortized time per insertion isO(1/ε2) for a (2 + ε)-approximation,O((log
λ)((log n)/ε)2) for a (1 + ε)-approximation, andO(λ log n) for the exact size,
wherenis the number of nodes in the graph and λ is the size of the minimum cut.
The (2 + ε)-approximation algorithm and the exact algorithm are deterministic;
the (1 + ε)-approximation algorithm is randomized. We also present a static 2-approximation
algorithm for the size κ of the minimum vertex cut in a graph, which takes time.
This is a factor of κ faster than the best algorithm for computing the exact size,
which takes time. We give an insertions-only algorithm for maintaining a (2 +
ε)-approximation of the minimum vertex cut with amortized insertion timeO(n/ε).
article_processing_charge: No
article_type: original
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
citation:
ama: Henzinger MH. A static 2-approximation algorithm for vertex connectivity and
incremental approximation algorithms for edge and vertex connectivity. Journal
of Algorithms. 1997;24(1):194-220. doi:10.1006/jagm.1997.0855
apa: Henzinger, M. H. (1997). A static 2-approximation algorithm for vertex connectivity
and incremental approximation algorithms for edge and vertex connectivity. Journal
of Algorithms. Elsevier. https://doi.org/10.1006/jagm.1997.0855
chicago: Henzinger, Monika H. “A Static 2-Approximation Algorithm for Vertex Connectivity
and Incremental Approximation Algorithms for Edge and Vertex Connectivity.” Journal
of Algorithms. Elsevier, 1997. https://doi.org/10.1006/jagm.1997.0855.
ieee: M. H. Henzinger, “A static 2-approximation algorithm for vertex connectivity
and incremental approximation algorithms for edge and vertex connectivity,” Journal
of Algorithms, vol. 24, no. 1. Elsevier, pp. 194–220, 1997.
ista: Henzinger MH. 1997. A static 2-approximation algorithm for vertex connectivity
and incremental approximation algorithms for edge and vertex connectivity. Journal
of Algorithms. 24(1), 194–220.
mla: Henzinger, Monika H. “A Static 2-Approximation Algorithm for Vertex Connectivity
and Incremental Approximation Algorithms for Edge and Vertex Connectivity.” Journal
of Algorithms, vol. 24, no. 1, Elsevier, 1997, pp. 194–220, doi:10.1006/jagm.1997.0855.
short: M.H. Henzinger, Journal of Algorithms 24 (1997) 194–220.
date_created: 2022-08-08T12:18:38Z
date_published: 1997-07-01T00:00:00Z
date_updated: 2022-09-12T09:15:38Z
day: '01'
doi: 10.1006/jagm.1997.0855
extern: '1'
intvolume: ' 24'
issue: '1'
language:
- iso: eng
month: '07'
oa_version: None
page: 194-220
publication: Journal of Algorithms
publication_identifier:
issn:
- 0196-6774
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: A static 2-approximation algorithm for vertex connectivity and incremental
approximation algorithms for edge and vertex connectivity
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 24
year: '1997'
...
---
_id: '11767'
abstract:
- lang: eng
text: We give a linear-time algorithm for single-source shortest paths in planar
graphs with nonnegative edge-lengths. Our algorithm also yields a linear-time
algorithm for maximum flow in a planar graph with the source and sink on the same
face. For the case where negative edge-lengths are allowed, we give an algorithm
requiringO(n4/3 log(nL)) time, whereLis the absolute value of the most negative
length. This algorithm can be used to obtain similar bounds for computing a feasible
flow in a planar network, for finding a perfect matching in a planar bipartite
graph, and for finding a maximum flow in a planar graph when the source and sink
are not on the same face. We also give parallel and dynamic versions of these
algorithms.
article_processing_charge: No
article_type: original
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Philip
full_name: Klein, Philip
last_name: Klein
- first_name: Satish
full_name: Rao, Satish
last_name: Rao
- first_name: Sairam
full_name: Subramanian, Sairam
last_name: Subramanian
citation:
ama: Henzinger MH, Klein P, Rao S, Subramanian S. Faster shortest-path algorithms
for planar graphs. Journal of Computer and System Sciences. 1997;55(1):3-23.
doi:10.1006/jcss.1997.1493
apa: Henzinger, M. H., Klein, P., Rao, S., & Subramanian, S. (1997). Faster
shortest-path algorithms for planar graphs. Journal of Computer and System
Sciences. Elsevier. https://doi.org/10.1006/jcss.1997.1493
chicago: Henzinger, Monika H, Philip Klein, Satish Rao, and Sairam Subramanian.
“Faster Shortest-Path Algorithms for Planar Graphs.” Journal of Computer and
System Sciences. Elsevier, 1997. https://doi.org/10.1006/jcss.1997.1493.
ieee: M. H. Henzinger, P. Klein, S. Rao, and S. Subramanian, “Faster shortest-path
algorithms for planar graphs,” Journal of Computer and System Sciences,
vol. 55, no. 1. Elsevier, pp. 3–23, 1997.
ista: Henzinger MH, Klein P, Rao S, Subramanian S. 1997. Faster shortest-path algorithms
for planar graphs. Journal of Computer and System Sciences. 55(1), 3–23.
mla: Henzinger, Monika H., et al. “Faster Shortest-Path Algorithms for Planar Graphs.”
Journal of Computer and System Sciences, vol. 55, no. 1, Elsevier, 1997,
pp. 3–23, doi:10.1006/jcss.1997.1493.
short: M.H. Henzinger, P. Klein, S. Rao, S. Subramanian, Journal of Computer and
System Sciences 55 (1997) 3–23.
date_created: 2022-08-08T12:28:45Z
date_published: 1997-08-01T00:00:00Z
date_updated: 2022-09-12T10:46:21Z
day: '01'
doi: 10.1006/jcss.1997.1493
extern: '1'
intvolume: ' 55'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1006/jcss.1997.1493
month: '08'
oa: 1
oa_version: Published Version
page: 3-23
publication: Journal of Computer and System Sciences
publication_identifier:
issn:
- 0022-0000
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Faster shortest-path algorithms for planar graphs
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 55
year: '1997'
...
---
_id: '8527'
abstract:
- lang: eng
text: We introduce a new potential-theoretic definition of the dimension spectrum of
a probability measure for q > 1 and explain its relation to prior definitions.
We apply this definition to prove that if and is a Borel probability measure
with compact support in , then under almost every linear transformation from to
, the q-dimension of the image of is ; in particular, the q-dimension of is
preserved provided . We also present results on the preservation of information
dimension and pointwise dimension. Finally, for and q > 2 we give examples for
which is not preserved by any linear transformation into . All results for typical
linear transformations are also proved for typical (in the sense of prevalence)
continuously differentiable functions.
article_processing_charge: No
article_type: original
author:
- first_name: Brian R
full_name: Hunt, Brian R
last_name: Hunt
- first_name: Vadim
full_name: Kaloshin, Vadim
id: FE553552-CDE8-11E9-B324-C0EBE5697425
last_name: Kaloshin
orcid: 0000-0002-6051-2628
citation:
ama: Hunt BR, Kaloshin V. How projections affect the dimension spectrum of fractal
measures. Nonlinearity. 1997;10(5):1031-1046. doi:10.1088/0951-7715/10/5/002
apa: Hunt, B. R., & Kaloshin, V. (1997). How projections affect the dimension
spectrum of fractal measures. Nonlinearity. IOP Publishing. https://doi.org/10.1088/0951-7715/10/5/002
chicago: Hunt, Brian R, and Vadim Kaloshin. “How Projections Affect the Dimension
Spectrum of Fractal Measures.” Nonlinearity. IOP Publishing, 1997. https://doi.org/10.1088/0951-7715/10/5/002.
ieee: B. R. Hunt and V. Kaloshin, “How projections affect the dimension spectrum
of fractal measures,” Nonlinearity, vol. 10, no. 5. IOP Publishing, pp.
1031–1046, 1997.
ista: Hunt BR, Kaloshin V. 1997. How projections affect the dimension spectrum of
fractal measures. Nonlinearity. 10(5), 1031–1046.
mla: Hunt, Brian R., and Vadim Kaloshin. “How Projections Affect the Dimension Spectrum
of Fractal Measures.” Nonlinearity, vol. 10, no. 5, IOP Publishing, 1997,
pp. 1031–46, doi:10.1088/0951-7715/10/5/002.
short: B.R. Hunt, V. Kaloshin, Nonlinearity 10 (1997) 1031–1046.
date_created: 2020-09-18T10:50:41Z
date_published: 1997-06-19T00:00:00Z
date_updated: 2021-01-12T08:19:53Z
day: '19'
doi: 10.1088/0951-7715/10/5/002
extern: '1'
intvolume: ' 10'
issue: '5'
keyword:
- Mathematical Physics
- General Physics and Astronomy
- Applied Mathematics
- Statistical and Nonlinear Physics
language:
- iso: eng
month: '06'
oa_version: None
page: 1031-1046
publication: Nonlinearity
publication_identifier:
issn:
- 0951-7715
- 1361-6544
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
status: public
title: How projections affect the dimension spectrum of fractal measures
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 10
year: '1997'
...
---
_id: '8528'
abstract:
- lang: eng
text: "In the present paper, we give a definition of prevalent (\"metrically prevalent\"
) sets in nonlinear function\r\nspaces. A subset of a Euclidean space is said
to be metrically prevalent if its complement has measure zero.\r\nThere is no
natural way to generalize the definition of a set of measure zero in a finite-dimensional
space\r\nto the infinite-dimensional case [6]. Therefore, it is necessary to give
a special definition of a metrically\r\nprevalent set (set of full measure) in
an infinite-dimensional space. There are various ways to do so. We\r\nsuggest
one of the possible ways to define the class of metrically prevalent sets in the
space of smooth maps\r\nof one smooth manifold into another. It is shown in this
paper that the class of metrically prevalent sets\r\nhas natural properties; in
particular, the intersection of finitely many metrically prevalent sets is metrically\r\nprevalent.
The main result of the paper is a prevalent version of Thorn's transversality
theorem.\r\nIt is common practice in singularity theory and the theory of dynamical
systems to say that a property\r\nholds for \"almost every\" map (or flow) if
it holds for a residual set, i.e., a set that contains a countable\r\nintersection
of open dense sets in the corresponding function space. However, even in finite-dimensional\r\nspaces
such a set can have arbitrarily small (say, zero) Lebesgue measure. We prove that
Thorn's transversality theorem holds for an essentially \"thicker\" set than a
residual set. It seems reasonable to revise from\r\nthe prevalent point of view
the classical results of singularity theory and theory of dynamical systems,\r\nincluding
the multijet transversality theorem, Mather's stability theorem, Kupka-Smale's
theorem for dynamical systems, etc. We shall do this elsewhere. The notion of
prevalence in linear Banach spaces was\r\nintroduced and investigated in [8].
One of the possible ways to define a class of prevalent sets in the space\r\nof
smooth maps of manifolds, which essentially differs from that presented in this
paper, is given in [7].\r\nDefinitions of typicalness based on the Lebesgue measure
in a finite-dimensional space were suggested\r\nby Kolmogorov [10] and Arnold
[11]. These definitions were cited and discussed in [9]. Here we only point\r\nout
that the finite-dimensional analog of Arnold's definition allows prevalent sets
to have arbitrarily small\r\nmeasure, whereas the prevalent sets in the sense
of the finite-dimensional analog of the definition given in\r\nthe present paper
are necessarily of full measure. Our definition is a modification of that due
to Arnold.\r\nI wish to thank Yu. S. Illyashenko for constant attention to this
work and useful discussions and\r\nR. I. Bogdanov for help in the preparation
of this paper. "
article_processing_charge: No
article_type: original
author:
- first_name: Vadim
full_name: Kaloshin, Vadim
id: FE553552-CDE8-11E9-B324-C0EBE5697425
last_name: Kaloshin
orcid: 0000-0002-6051-2628
citation:
ama: Kaloshin V. Prevalence in the space of finitely smooth maps. Functional
Analysis and Its Applications. 1997;31(2):95-99. doi:10.1007/bf02466014
apa: Kaloshin, V. (1997). Prevalence in the space of finitely smooth maps. Functional
Analysis and Its Applications. Springer Nature. https://doi.org/10.1007/bf02466014
chicago: Kaloshin, Vadim. “Prevalence in the Space of Finitely Smooth Maps.” Functional
Analysis and Its Applications. Springer Nature, 1997. https://doi.org/10.1007/bf02466014.
ieee: V. Kaloshin, “Prevalence in the space of finitely smooth maps,” Functional
Analysis and Its Applications, vol. 31, no. 2. Springer Nature, pp. 95–99,
1997.
ista: Kaloshin V. 1997. Prevalence in the space of finitely smooth maps. Functional
Analysis and Its Applications. 31(2), 95–99.
mla: Kaloshin, Vadim. “Prevalence in the Space of Finitely Smooth Maps.” Functional
Analysis and Its Applications, vol. 31, no. 2, Springer Nature, 1997, pp.
95–99, doi:10.1007/bf02466014.
short: V. Kaloshin, Functional Analysis and Its Applications 31 (1997) 95–99.
date_created: 2020-09-18T10:50:54Z
date_published: 1997-03-30T00:00:00Z
date_updated: 2021-01-12T08:19:54Z
day: '30'
doi: 10.1007/bf02466014
extern: '1'
intvolume: ' 31'
issue: '2'
keyword:
- Applied Mathematics
- Analysis
language:
- iso: eng
month: '03'
oa_version: None
page: 95-99
publication: Functional Analysis and Its Applications
publication_identifier:
issn:
- 0016-2663
- 1573-8485
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Prevalence in the space of finitely smooth maps
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 31
year: '1997'
...
---
_id: '4583'
abstract:
- lang: eng
text: In a trace-based world, the modular specification, verification, and control
of live systems require each module to be receptive; that is, each module must
be able to meet its liveness assumptions no matter how the other modules behave.
In a real-time world, liveness is automatically present in the form of diverging
time. The receptiveness condition, then, translates to the requirement that a
module must be able to let time diverge no matter how the environment behaves.
We study the receptiveness condition for real-time systems by extending the model
of reactive modules to timed and hybrid modules. We define the receptiveness of
such a module as the existence of a winning strategy in a game of the module against
its environment. By solving the game on region graphs, we present an (optimal)
Exptime algorithm for checking the receptiveness of prepositional timed modules.
By giving a fixpoint characterization of the game, we present a symbolic procedure
for checking the receptiveness of linear hybrid modules. Finally, we present an
assume-guarantee principle for reasoning about timed and hybrid modules, and a
method for synthesizing receptive controllers of timed and hybrid modules.
acknowledgement: This research was supported in part by the ONR YIP award N00014-95-1-0520,
by the NSF CAREER award CCR-9501708, by the NSF grant CCR-9504469, by the AFOSR
contract F49620-93-1-0056, by the ARO MURI grant DAAH-04-96-1-0341, by the ARPA
grant NAG2-892, and by the SRC contract 95-DC-324.036.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Rajeev
full_name: Alur, Rajeev
last_name: Alur
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
citation:
ama: 'Alur R, Henzinger TA. Modularity for timed and hybrid systems. In: 8th
International Conference on Concurrency Theory. Vol 1243. Schloss Dagstuhl
- Leibniz-Zentrum für Informatik; 1997:74-88. doi:10.1007/3-540-63141-0_6'
apa: 'Alur, R., & Henzinger, T. A. (1997). Modularity for timed and hybrid systems.
In 8th International Conference on Concurrency Theory (Vol. 1243, pp. 74–88).
Warsaw, Poland: Schloss Dagstuhl - Leibniz-Zentrum für Informatik. https://doi.org/10.1007/3-540-63141-0_6'
chicago: Alur, Rajeev, and Thomas A Henzinger. “Modularity for Timed and Hybrid
Systems.” In 8th International Conference on Concurrency Theory, 1243:74–88.
Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 1997. https://doi.org/10.1007/3-540-63141-0_6.
ieee: R. Alur and T. A. Henzinger, “Modularity for timed and hybrid systems,” in
8th International Conference on Concurrency Theory, Warsaw, Poland, 1997,
vol. 1243, pp. 74–88.
ista: 'Alur R, Henzinger TA. 1997. Modularity for timed and hybrid systems. 8th
International Conference on Concurrency Theory. CONCUR: Concurrency Theory, LNCS,
vol. 1243, 74–88.'
mla: Alur, Rajeev, and Thomas A. Henzinger. “Modularity for Timed and Hybrid Systems.”
8th International Conference on Concurrency Theory, vol. 1243, Schloss
Dagstuhl - Leibniz-Zentrum für Informatik, 1997, pp. 74–88, doi:10.1007/3-540-63141-0_6.
short: R. Alur, T.A. Henzinger, in:, 8th International Conference on Concurrency
Theory, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 1997, pp. 74–88.
conference:
end_date: 1997-07-04
location: Warsaw, Poland
name: 'CONCUR: Concurrency Theory'
start_date: 1997-07-01
date_created: 2018-12-11T12:09:36Z
date_published: 1997-01-01T00:00:00Z
date_updated: 2022-08-17T08:47:55Z
day: '01'
doi: 10.1007/3-540-63141-0_6
extern: '1'
intvolume: ' 1243'
language:
- iso: eng
month: '01'
oa_version: None
page: 74 - 88
publication: 8th International Conference on Concurrency Theory
publication_identifier:
isbn:
- '9783540691884'
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
publist_id: '124'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Modularity for timed and hybrid systems
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1243
year: '1997'
...
---
_id: '4584'
abstract:
- lang: eng
text: This paper introduces, gently but rigorously, the clock approach to real-time
programming. We present with mathematical precision, assuming no prerequisites
other than familiarity with logical and programming notations, the concepts that
are necessary for understanding, writing, and executing clock programs. In keeping
with an expository style, all references are clustered in bibliographic remarks
at the end of each section. The first appendix presents proof rules for verifying
temporal properties of clock programs. The second appendix points to selected
literature on formal methods and tools for programming with clocks. In particular,
the timed automaton, which is a finite-state machine equipped with clocks, has
become a standard paradigm for real-time model checking; it underlies the tools
HyTech, Kronos, and Uppaal, which are discussed elsewhere in this volume.
acknowledgement: The authors thank Rance Cleaveland, Limor Fix, David Karr, Peter
Kopke, Fred Schneider, and Bernhard Steffen for helpful comments.
article_processing_charge: No
article_type: original
author:
- first_name: Rajeev
full_name: Alur, Rajeev
last_name: Alur
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
citation:
ama: Alur R, Henzinger TA. Real-time system = discrete system + clock variables.
Software Tools For Technology Transfer. 1997;1(1-2):86-109. doi:10.1007/s100090050007
apa: Alur, R., & Henzinger, T. A. (1997). Real-time system = discrete system
+ clock variables. Software Tools For Technology Transfer. Springer. https://doi.org/10.1007/s100090050007
chicago: Alur, Rajeev, and Thomas A Henzinger. “Real-Time System = Discrete System
+ Clock Variables.” Software Tools For Technology Transfer. Springer, 1997.
https://doi.org/10.1007/s100090050007.
ieee: R. Alur and T. A. Henzinger, “Real-time system = discrete system + clock variables,”
Software Tools For Technology Transfer, vol. 1, no. 1–2. Springer, pp.
86–109, 1997.
ista: Alur R, Henzinger TA. 1997. Real-time system = discrete system + clock variables.
Software Tools For Technology Transfer. 1(1–2), 86–109.
mla: Alur, Rajeev, and Thomas A. Henzinger. “Real-Time System = Discrete System
+ Clock Variables.” Software Tools For Technology Transfer, vol. 1, no.
1–2, Springer, 1997, pp. 86–109, doi:10.1007/s100090050007.
short: R. Alur, T.A. Henzinger, Software Tools For Technology Transfer 1 (1997)
86–109.
date_created: 2018-12-11T12:09:36Z
date_published: 1997-01-01T00:00:00Z
date_updated: 2022-08-17T08:27:20Z
day: '01'
doi: 10.1007/s100090050007
extern: '1'
intvolume: ' 1'
issue: 1-2
language:
- iso: eng
month: '01'
oa_version: None
page: 86 - 109
publication: Software Tools For Technology Transfer
publication_identifier:
issn:
- 1433-2779
publication_status: published
publisher: Springer
publist_id: '123'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Real-time system = discrete system + clock variables
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1
year: '1997'
...
---
_id: '4605'
abstract:
- lang: eng
text: A hybrid system is a dynamical system whose behavior exhibits both discrete
and continuous change. A hybrid automaton is a mathematical model for hybrid systems,
which combines, in a single formalism, automaton transitions for capturing discrete
change with differential equations for capturing continuous change. In this survey,
we demonstrate symbolic algorithms for the verification of and controller synthesis
for linear hybrid automata, a subclass of hybrid automata that can be analyzed
automatically
article_processing_charge: No
author:
- first_name: Rajeev
full_name: Alur, Rajeev
last_name: Alur
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Howard
full_name: Wong Toi, Howard
last_name: Wong Toi
citation:
ama: 'Alur R, Henzinger TA, Wong Toi H. Symbolic analysis of hybrid systems. In:
Proceedings of the 36th IEEE Conference on Decision and Control. IEEE;
1997:702-707. doi:10.1109/CDC.1997.650717
'
apa: 'Alur, R., Henzinger, T. A., & Wong Toi, H. (1997). Symbolic analysis of
hybrid systems. In Proceedings of the 36th IEEE Conference on Decision and
Control (pp. 702–707). San Diego, CA, USA: IEEE. https://doi.org/10.1109/CDC.1997.650717 '
chicago: Alur, Rajeev, Thomas A Henzinger, and Howard Wong Toi. “Symbolic Analysis
of Hybrid Systems.” In Proceedings of the 36th IEEE Conference on Decision
and Control, 702–7. IEEE, 1997. https://doi.org/10.1109/CDC.1997.650717 .
ieee: R. Alur, T. A. Henzinger, and H. Wong Toi, “Symbolic analysis of hybrid systems,”
in Proceedings of the 36th IEEE Conference on Decision and Control, San
Diego, CA, USA, 1997, pp. 702–707.
ista: 'Alur R, Henzinger TA, Wong Toi H. 1997. Symbolic analysis of hybrid systems.
Proceedings of the 36th IEEE Conference on Decision and Control. CDC: Decision
and Control, 702–707.'
mla: Alur, Rajeev, et al. “Symbolic Analysis of Hybrid Systems.” Proceedings
of the 36th IEEE Conference on Decision and Control, IEEE, 1997, pp. 702–07,
doi:10.1109/CDC.1997.650717
.
short: R. Alur, T.A. Henzinger, H. Wong Toi, in:, Proceedings of the 36th IEEE Conference
on Decision and Control, IEEE, 1997, pp. 702–707.
conference:
end_date: 1997-12-12
location: San Diego, CA, USA
name: 'CDC: Decision and Control'
start_date: 1997-12-12
date_created: 2018-12-11T12:09:43Z
date_published: 1997-12-01T00:00:00Z
date_updated: 2022-08-17T08:08:36Z
day: '01'
doi: '10.1109/CDC.1997.650717 '
extern: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 702 - 707
publication: Proceedings of the 36th IEEE Conference on Decision and Control
publication_identifier:
isbn:
- '0780341872'
publication_status: published
publisher: IEEE
publist_id: '101'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Symbolic analysis of hybrid systems
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '1997'
...
---
_id: '4607'
abstract:
- lang: eng
text: We present a verification algorithm for duration properties of real-time systems.
While simple real-time properties constrain the total elapsed time between events,
duration properties constrain the accumulated satisfaction time of state predicates.
We formalize the concept of durations by introducing duration measures for timed
automata. A duration measure assigns to each finite run of a timed automaton a
real number —the duration of the run— which may be the accumulated satisfaction
time of a state predicate along the run. Given a timed automaton with a duration
measure, an initial and a final state, and an arithmetic constraint, the duration-bounded
reachability problem asks if there is a run of the automaton from the initial
state to the final state such that the duration of the run satisfies the constraint.
Our main result is an (optimal) PSPACE decision procedure for the duration-bounded
reachability problem.
acknowledgement: "A preliminary version of this paper appeared in the Proceedings
of the Fifth International Conference on Computer-Aided Verification (CAV 93), Springer-Verlag
LNCS 818, pp. 181–193, 1993. We thank Sergio Yovine for a careful reading of the
manuscript. This reaserch was partially supported by the BRA ESPRIT project REACT,
by the ONR YIP\r\naward N00014-95-1-0520, by the NSF CAREER award CCR-9501708, by
the NSF grants CCR-9200794 and CCR-9504469, by the AFOSR contract F49620-93-1-0056,
and by the ARPA grant NAG2-892."
article_processing_charge: No
article_type: original
author:
- first_name: Rajeev
full_name: Alur, Rajeev
last_name: Alur
- first_name: Costas
full_name: Courcoubetis, Costas
last_name: Courcoubetis
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
citation:
ama: Alur R, Courcoubetis C, Henzinger TA. Computing accumulated delays in real-time
systems. Formal Methods in System Design. 1997;11(2):137-156. doi:10.1023/A:1008626013578
apa: Alur, R., Courcoubetis, C., & Henzinger, T. A. (1997). Computing accumulated
delays in real-time systems. Formal Methods in System Design. Springer.
https://doi.org/10.1023/A:1008626013578
chicago: Alur, Rajeev, Costas Courcoubetis, and Thomas A Henzinger. “Computing Accumulated
Delays in Real-Time Systems.” Formal Methods in System Design. Springer,
1997. https://doi.org/10.1023/A:1008626013578.
ieee: R. Alur, C. Courcoubetis, and T. A. Henzinger, “Computing accumulated delays
in real-time systems,” Formal Methods in System Design, vol. 11, no. 2.
Springer, pp. 137–156, 1997.
ista: Alur R, Courcoubetis C, Henzinger TA. 1997. Computing accumulated delays in
real-time systems. Formal Methods in System Design. 11(2), 137–156.
mla: Alur, Rajeev, et al. “Computing Accumulated Delays in Real-Time Systems.” Formal
Methods in System Design, vol. 11, no. 2, Springer, 1997, pp. 137–56, doi:10.1023/A:1008626013578.
short: R. Alur, C. Courcoubetis, T.A. Henzinger, Formal Methods in System Design
11 (1997) 137–156.
date_created: 2018-12-11T12:09:43Z
date_published: 1997-01-01T00:00:00Z
date_updated: 2022-08-16T13:43:41Z
day: '01'
doi: 10.1023/A:1008626013578
extern: '1'
intvolume: ' 11'
issue: '2'
language:
- iso: eng
month: '01'
oa_version: None
page: 137 - 156
publication: Formal Methods in System Design
publication_identifier:
issn:
- 0925-9856
publication_status: published
publisher: Springer
publist_id: '98'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Computing accumulated delays in real-time systems
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 11
year: '1997'
...