---
_id: '4588'
abstract:
- lang: eng
  text: 'We present a formal model for concurrent systems. The model represents synchronous
    and asynchronous components in a uniform framework that supports compositional
    (assume-guarantee) and hierarchical (stepwise refinement) reasoning. While synchronous
    models are based on a notion of atomic computation step, and asynchronous models
    remove that notion by introducing stuttering, our model is based on a flexible
    notion of what constitutes a computation step: by applying an abstraction operator
    to a system, arbitrarily many consecutive steps can be collapsed into a single
    step. The abstraction operator, which may turn an asynchronous system into a synchronous
    one, allows us to describe systems at various levels of temporal detail. For describing
    systems at various levels of spatial detail, we use a hiding operator that may
    turn a synchronous system into an asynchronous one. We illustrate the model with
    diverse examples from synchronous circuits, asynchronous shared-memory programs,
    and synchronous message passing'
article_processing_charge: No
author:
- first_name: Rajeev
  full_name: Alur, Rajeev
  last_name: Alur
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
citation:
  ama: 'Alur R, Henzinger TA. Reactive modules. In: <i>Proceedings 11th Annual IEEE
    Symposium on Logic in Computer Science</i>. IEEE; 1996:207-218. doi:<a href="https://doi.org/10.1109/LICS.1996.561320">10.1109/LICS.1996.561320</a>'
  apa: 'Alur, R., &#38; Henzinger, T. A. (1996). Reactive modules. In <i>Proceedings
    11th Annual IEEE Symposium on Logic in Computer Science</i> (pp. 207–218). New
    Brunswick, NJ, USA: IEEE. <a href="https://doi.org/10.1109/LICS.1996.561320">https://doi.org/10.1109/LICS.1996.561320</a>'
  chicago: Alur, Rajeev, and Thomas A Henzinger. “Reactive Modules.” In <i>Proceedings
    11th Annual IEEE Symposium on Logic in Computer Science</i>, 207–18. IEEE, 1996.
    <a href="https://doi.org/10.1109/LICS.1996.561320">https://doi.org/10.1109/LICS.1996.561320</a>.
  ieee: R. Alur and T. A. Henzinger, “Reactive modules,” in <i>Proceedings 11th Annual
    IEEE Symposium on Logic in Computer Science</i>, New Brunswick, NJ, USA, 1996,
    pp. 207–218.
  ista: 'Alur R, Henzinger TA. 1996. Reactive modules. Proceedings 11th Annual IEEE
    Symposium on Logic in Computer Science. LICS: Logic in Computer Science, 207–218.'
  mla: Alur, Rajeev, and Thomas A. Henzinger. “Reactive Modules.” <i>Proceedings 11th
    Annual IEEE Symposium on Logic in Computer Science</i>, IEEE, 1996, pp. 207–18,
    doi:<a href="https://doi.org/10.1109/LICS.1996.561320">10.1109/LICS.1996.561320</a>.
  short: R. Alur, T.A. Henzinger, in:, Proceedings 11th Annual IEEE Symposium on Logic
    in Computer Science, IEEE, 1996, pp. 207–218.
conference:
  end_date: 1996-07-30
  location: New Brunswick, NJ, USA
  name: 'LICS: Logic in Computer Science'
  start_date: 1996-07-27
date_created: 2018-12-11T12:09:37Z
date_published: 1996-01-01T00:00:00Z
date_updated: 2022-07-04T14:51:40Z
day: '01'
doi: 10.1109/LICS.1996.561320
extern: '1'
language:
- iso: eng
main_file_link:
- url: https://ieeexplore.ieee.org/document/561320
month: '01'
oa_version: None
page: 207 - 218
publication: Proceedings 11th Annual IEEE Symposium on Logic in Computer Science
publication_identifier:
  issn:
  - 0018-9162
publication_status: published
publisher: IEEE
publist_id: '121'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Reactive modules
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '1996'
...
---
_id: '4610'
abstract:
- lang: eng
  text: The most natural, compositional, way of modeling real-time systems uses a
    dense domain for time. The satisfiability of timing constraints that are capable
    of expressing punctuality in this model, however, is known to be undecidable.
    We introduce a temporal language that can constrain the time difference between
    events only with finite, yet arbitrary, precision and show the resulting logic
    to be EXPSPACE-complete. This result allows us to develop an algorithm for the
    verification of timing properties of real-time systems with a dense semantics.
acknowledgement: 'We wish to thank an anonymous referee for pointing out the PSPACE-fragment
  of Section 4.5. '
article_processing_charge: No
article_type: original
author:
- first_name: Rajeev
  full_name: Alur, Rajeev
  last_name: Alur
- first_name: Tomás
  full_name: Feder, Tomás
  last_name: Feder
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
citation:
  ama: Alur R, Feder T, Henzinger TA. The benefits of relaxing punctuality. <i>Journal
    of the ACM</i>. 1996;43(1):116-146. doi:<a href="https://doi.org/10.1145/227595.227602">10.1145/227595.227602</a>
  apa: Alur, R., Feder, T., &#38; Henzinger, T. A. (1996). The benefits of relaxing
    punctuality. <i>Journal of the ACM</i>. ACM. <a href="https://doi.org/10.1145/227595.227602">https://doi.org/10.1145/227595.227602</a>
  chicago: Alur, Rajeev, Tomás Feder, and Thomas A Henzinger. “The Benefits of Relaxing
    Punctuality.” <i>Journal of the ACM</i>. ACM, 1996. <a href="https://doi.org/10.1145/227595.227602">https://doi.org/10.1145/227595.227602</a>.
  ieee: R. Alur, T. Feder, and T. A. Henzinger, “The benefits of relaxing punctuality,”
    <i>Journal of the ACM</i>, vol. 43, no. 1. ACM, pp. 116–146, 1996.
  ista: Alur R, Feder T, Henzinger TA. 1996. The benefits of relaxing punctuality.
    Journal of the ACM. 43(1), 116–146.
  mla: Alur, Rajeev, et al. “The Benefits of Relaxing Punctuality.” <i>Journal of
    the ACM</i>, vol. 43, no. 1, ACM, 1996, pp. 116–46, doi:<a href="https://doi.org/10.1145/227595.227602">10.1145/227595.227602</a>.
  short: R. Alur, T. Feder, T.A. Henzinger, Journal of the ACM 43 (1996) 116–146.
date_created: 2018-12-11T12:09:44Z
date_published: 1996-01-01T00:00:00Z
date_updated: 2022-07-04T12:38:01Z
day: '01'
doi: 10.1145/227595.227602
extern: '1'
intvolume: '        43'
issue: '1'
language:
- iso: eng
main_file_link:
- url: https://dl.acm.org/doi/10.1145/227595.227602
month: '01'
oa_version: None
page: 116 - 146
publication: Journal of the ACM
publication_identifier:
  issn:
  - 0004-5411
publication_status: published
publisher: ACM
publist_id: '95'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The benefits of relaxing punctuality
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 43
year: '1996'
...
---
_id: '4611'
abstract:
- lang: eng
  text: Presents a model-checking procedure and its implementation for the automatic
    verification of embedded systems. The system components are described as hybrid
    automata-communicating machines with finite control and real-valued variables
    that represent continuous environment parameters such as time, pressure and temperature.
    The system requirements are specified in a temporal logic with stop-watches, and
    verified by symbolic fixpoint computation. The verification procedure-implemented
    in the Cornell Hybrid Technology tool, HyTech-applies to hybrid automata whose
    continuous dynamics is governed by linear constraints on the variables and their
    derivatives. We illustrate the method and the tool by checking safety, liveness,
    time-bounded and duration requirements of digital controllers, schedulers and
    distributed algorithms
acknowledgement: "We thank Costas Courcoubetis, Nicolas Halbwachs, Peter Kopke, Joseph
  Sifakis, and Howard Wong-Toi for helpful\r\ndiscussions and valuable comments. Thomas
  A. Henzinger's research was supported in part by the U.S. Office of Naval Research
  Young Investigator award N00014-95-1-0520, by the National Science Foundation CAREER
  award CCR-9501708, by National Science Foundation grants CCR-9200794 and CCR-9504469,
  by U.S. Air Force Office of Scientific Research contract F49620-93-1- 0056, and
  by Advanced Research Projects Agency grant NAG2-892. "
article_processing_charge: No
article_type: original
author:
- first_name: Rajeev
  full_name: Alur, Rajeev
  last_name: Alur
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
- first_name: Pei
  full_name: Ho, Pei
  last_name: Ho
citation:
  ama: Alur R, Henzinger TA, Ho P. Automatic symbolic verification of embedded systems.
    <i>IEEE Transactions on Software Engineering</i>. 1996;22(3):181-201. doi:<a href="https://doi.org/10.1109/32.489079">10.1109/32.489079</a>
  apa: Alur, R., Henzinger, T. A., &#38; Ho, P. (1996). Automatic symbolic verification
    of embedded systems. <i>IEEE Transactions on Software Engineering</i>. IEEE. <a
    href="https://doi.org/10.1109/32.489079">https://doi.org/10.1109/32.489079</a>
  chicago: Alur, Rajeev, Thomas A Henzinger, and Pei Ho. “Automatic Symbolic Verification
    of Embedded Systems.” <i>IEEE Transactions on Software Engineering</i>. IEEE,
    1996. <a href="https://doi.org/10.1109/32.489079">https://doi.org/10.1109/32.489079</a>.
  ieee: R. Alur, T. A. Henzinger, and P. Ho, “Automatic symbolic verification of embedded
    systems,” <i>IEEE Transactions on Software Engineering</i>, vol. 22, no. 3. IEEE,
    pp. 181–201, 1996.
  ista: Alur R, Henzinger TA, Ho P. 1996. Automatic symbolic verification of embedded
    systems. IEEE Transactions on Software Engineering. 22(3), 181–201.
  mla: Alur, Rajeev, et al. “Automatic Symbolic Verification of Embedded Systems.”
    <i>IEEE Transactions on Software Engineering</i>, vol. 22, no. 3, IEEE, 1996,
    pp. 181–201, doi:<a href="https://doi.org/10.1109/32.489079">10.1109/32.489079</a>.
  short: R. Alur, T.A. Henzinger, P. Ho, IEEE Transactions on Software Engineering
    22 (1996) 181–201.
date_created: 2018-12-11T12:09:45Z
date_published: 1996-03-01T00:00:00Z
date_updated: 2022-07-04T12:47:05Z
day: '01'
doi: 10.1109/32.489079
extern: '1'
intvolume: '        22'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://ecommons.cornell.edu/handle/1813/7170
month: '03'
oa: 1
oa_version: Published Version
page: 181 - 201
publication: IEEE Transactions on Software Engineering
publication_identifier:
  issn:
  - 0018-9162
publication_status: published
publisher: IEEE
publist_id: '96'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Automatic symbolic verification of embedded systems
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 22
year: '1996'
...
---
_id: '4612'
alternative_title:
- LNCS
article_processing_charge: No
citation:
  ama: 'Alur R, Henzinger TA, Sontag ED, eds. <i>Hybrid Systems III: Verification
    and Control</i>. Vol 1066. Berlin ; Heidelberg: Springer; 1996. doi:<a href="https://doi.org/10.1007/BFb0020931">10.1007/BFb0020931</a>'
  apa: 'Alur, R., Henzinger, T. A., &#38; Sontag, E. D. (Eds.). (1996). <i>Hybrid
    Systems III: Verification and Control</i> (Vol. 1066). Berlin ; Heidelberg: Springer.
    <a href="https://doi.org/10.1007/BFb0020931">https://doi.org/10.1007/BFb0020931</a>'
  chicago: 'Alur, Rajeev, Thomas A Henzinger, and Eduardo D Sontag, eds. <i>Hybrid
    Systems III: Verification and Control</i>. Vol. 1066. Lecture Notes in Computer
    Science. Berlin ; Heidelberg: Springer, 1996. <a href="https://doi.org/10.1007/BFb0020931">https://doi.org/10.1007/BFb0020931</a>.'
  ieee: 'R. Alur, T. A. Henzinger, and E. D. Sontag, Eds., <i>Hybrid Systems III:
    Verification and Control</i>, vol. 1066. Berlin ; Heidelberg: Springer, 1996.'
  ista: 'Alur R, Henzinger TA, Sontag ED eds. 1996. Hybrid Systems III: Verification
    and Control, Berlin ; Heidelberg: Springer, IX, 619p.'
  mla: 'Alur, Rajeev, et al., editors. <i>Hybrid Systems III: Verification and Control</i>.
    Vol. 1066, Springer, 1996, doi:<a href="https://doi.org/10.1007/BFb0020931">10.1007/BFb0020931</a>.'
  short: 'R. Alur, T.A. Henzinger, E.D. Sontag, eds., Hybrid Systems III: Verification
    and Control, Springer, Berlin ; Heidelberg, 1996.'
date_created: 2018-12-11T12:09:45Z
date_published: 1996-01-01T00:00:00Z
date_updated: 2021-12-22T13:57:33Z
day: '01'
doi: 10.1007/BFb0020931
editor:
- first_name: Rajeev
  full_name: Alur, Rajeev
  last_name: Alur
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
- first_name: Eduardo D
  full_name: Sontag, Eduardo D
  last_name: Sontag
extern: '1'
intvolume: '      1066'
language:
- iso: eng
month: '01'
oa_version: None
page: IX, 619
place: Berlin ; Heidelberg
publication_identifier:
  isbn:
  - 978-3-540-61155-4
  issn:
  - 0302-9743
publication_status: published
publisher: Springer
publist_id: '97'
quality_controlled: '1'
series_title: Lecture Notes in Computer Science
status: public
title: 'Hybrid Systems III: Verification and Control'
type: book_editor
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 1066
year: '1996'
...
---
_id: '6161'
abstract:
- lang: eng
  text: 'The tra-1 gene is a terminal regulator of somatic sex in Caenorhabditis elegans:
    high tra-1 activity elicits female development, low tra-1 activity elicits male
    development. To investigate the function and evolution of tra- 1, we examined
    the tra-1 gene from the closely related nematode C. briggsae. Ce-tra-1 and Cb-tra-1
    are unusually divergent. Each gene generates two transcripts, but only one of
    these is present in both species. This common transcript encodes TRA-1A, which
    shows only 44% amino acid identity between the species, a figure much lower than
    that for previously compared genes. A Cb-tra-1 transgene rescues many tissues
    of tra-1(null) mutants of C. elegans but not the somatic gonad or germ line. This
    transgene also causes nongonadal feminization of XO animals, indicating incorrect
    sexual regulation. Alignment of Ce-TRA-1A and Cb-TRA-1A defined several conserved
    regions likely to be important for tra-1 function. The phenotype differences between
    Ce-tra- 1(null) mutants rescued by Cb-tra-1 transgenes and wild-type C. elegans
    indicate significant divergence of regulatory regions. These molecular and functional
    studies suggest that evolution of sex determination in nematodes is rapid and
    genetically complex.'
author:
- first_name: Mario
  full_name: de Bono, Mario
  id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
  last_name: de Bono
  orcid: 0000-0001-8347-0443
- first_name: J.
  full_name: Hodgkin, J.
  last_name: Hodgkin
citation:
  ama: 'de Bono M, Hodgkin J. Evolution of sex determination in Caenorhabditis: Unusually
    high divergence of tra-1 and its functional consequences. <i>Genetics</i>. 1996;144(2):587-595.'
  apa: 'de Bono, M., &#38; Hodgkin, J. (1996). Evolution of sex determination in Caenorhabditis:
    Unusually high divergence of tra-1 and its functional consequences. <i>Genetics</i>.
    Genetics Society of America.'
  chicago: 'Bono, Mario de, and J. Hodgkin. “Evolution of Sex Determination in Caenorhabditis:
    Unusually High Divergence of Tra-1 and Its Functional Consequences.” <i>Genetics</i>.
    Genetics Society of America, 1996.'
  ieee: 'M. de Bono and J. Hodgkin, “Evolution of sex determination in Caenorhabditis:
    Unusually high divergence of tra-1 and its functional consequences,” <i>Genetics</i>,
    vol. 144, no. 2. Genetics Society of America, pp. 587–595, 1996.'
  ista: 'de Bono M, Hodgkin J. 1996. Evolution of sex determination in Caenorhabditis:
    Unusually high divergence of tra-1 and its functional consequences. Genetics.
    144(2), 587–595.'
  mla: 'de Bono, Mario, and J. Hodgkin. “Evolution of Sex Determination in Caenorhabditis:
    Unusually High Divergence of Tra-1 and Its Functional Consequences.” <i>Genetics</i>,
    vol. 144, no. 2, Genetics Society of America, 1996, pp. 587–95.'
  short: M. de Bono, J. Hodgkin, Genetics 144 (1996) 587–595.
date_created: 2019-03-21T11:50:37Z
date_published: 1996-10-01T00:00:00Z
date_updated: 2021-01-12T08:06:28Z
day: '01'
extern: '1'
external_id:
  pmid:
  - '8889522'
intvolume: '       144'
issue: '2'
keyword:
- amino acid sequence
- article
- caenorhabditis elegans
- evolution
- genetic variability
- nonhuman
- priority journal
- sex determination
- Amino Acid Sequence
- Animals
- Animals
- Genetically Modified
- Base Sequence
- Caenorhabditis
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- DNA
- Helminth
- DNA-Binding Proteins
- Evolution
- Molecular
- Female
- Helminth Proteins
- Membrane Proteins
- Molecular Sequence Data
- Mutagenesis
- RNA
- Messenger
- Sequence Homology
- Amino Acid
- Sex Determination (Analysis)
- Transcription Factors
- Transgenes
- Turner Syndrome
- Animalia
- Caenorhabditis
- Caenorhabditis briggsae
- Caenorhabditis elegans
- Nematoda
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1207552/
month: '10'
oa: 1
oa_version: Published Version
page: 587-595
pmid: 1
publication: Genetics
publication_identifier:
  issn:
  - '00166731'
publication_status: published
publisher: Genetics Society of America
quality_controlled: '1'
status: public
title: 'Evolution of sex determination in Caenorhabditis: Unusually high divergence
  of tra-1 and its functional consequences'
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 144
year: '1996'
...
---
_id: '11804'
abstract:
- lang: eng
  text: "This paper shows how a general technique, called lock-step search, used in
    dynamic graph algorithms, can be used to improve the running time of two problems
    arising in program verification and communication protocol design.\r\n(1)We consider
    the nonemptiness problem for Streett automata: We are given a directed graph G
    = (V, E) with n = ¦V¦ and m = ¦E¦, and a collection of pairs of subsets of vertices,
    called Streett pairs,〈L i , U i 〉, i = 1.k. The question is whether G has a cycle
    (not necessarily simple) which, for each 1 ≤ i ≤ k, if it contains a vertex from
    L i then it also contains a vertex of U i . Let b=Σ i=1..k |L i |+|U i |. The
    previously best algorithm takes time O((m + b) min{n, k}). We present an algorithm
    that takes time \U0001D442(\U0001D45Amin{\U0001D45A\U0001D459\U0001D45C\U0001D454\U0001D45B,‾‾‾‾‾‾√\U0001D458,\U0001D45B}+\U0001D44F\U0001D45A\U0001D456\U0001D45B{\U0001D459\U0001D45C\U0001D454\U0001D45B,\U0001D458}).\r\n(2)In
    communication protocol pruning we are given a directed graph G = (V, E) with l
    special vertices. The problem is to efficiently maintain the strongly-connected
    components of the special vertices on a restricted set of edge deletions. Let
    m i be the number of edges in the strongly connected component of the ith special
    vertex. The previously best algorithm repeatedly recomputes the strongly-connected
    components which leads to a running time of O(Σ i m 2i). We present an algorithm
    with time \U0001D442(\U0001D459√∑\U0001D456\U0001D45A1.5\U0001D456)."
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Monika H
  full_name: Henzinger, Monika H
  id: 540c9bbd-f2de-11ec-812d-d04a5be85630
  last_name: Henzinger
  orcid: 0000-0002-5008-6530
- first_name: Jan Arne
  full_name: Telle, Jan Arne
  last_name: Telle
citation:
  ama: 'Henzinger MH, Telle JA. Faster algorithms for the nonemptiness of streett
    automata and for communication protocol pruning. In: <i>5th Scandinavian Workshop
    on Algorithm Theory</i>. Vol 1097. Springer Nature; 1996:16–27. doi:<a href="https://doi.org/10.1007/3-540-61422-2_117">10.1007/3-540-61422-2_117</a>'
  apa: 'Henzinger, M. H., &#38; Telle, J. A. (1996). Faster algorithms for the nonemptiness
    of streett automata and for communication protocol pruning. In <i>5th Scandinavian
    Workshop on Algorithm Theory</i> (Vol. 1097, pp. 16–27). Reykjavik, Iceland: Springer
    Nature. <a href="https://doi.org/10.1007/3-540-61422-2_117">https://doi.org/10.1007/3-540-61422-2_117</a>'
  chicago: Henzinger, Monika H, and Jan Arne Telle. “Faster Algorithms for the Nonemptiness
    of Streett Automata and for Communication Protocol Pruning.” In <i>5th Scandinavian
    Workshop on Algorithm Theory</i>, 1097:16–27. Springer Nature, 1996. <a href="https://doi.org/10.1007/3-540-61422-2_117">https://doi.org/10.1007/3-540-61422-2_117</a>.
  ieee: M. H. Henzinger and J. A. Telle, “Faster algorithms for the nonemptiness of
    streett automata and for communication protocol pruning,” in <i>5th Scandinavian
    Workshop on Algorithm Theory</i>, Reykjavik, Iceland, 1996, vol. 1097, pp. 16–27.
  ista: 'Henzinger MH, Telle JA. 1996. Faster algorithms for the nonemptiness of streett
    automata and for communication protocol pruning. 5th Scandinavian Workshop on
    Algorithm Theory. SWAT: Scandinavian Workshop on Algorithm Theory, LNCS, vol.
    1097, 16–27.'
  mla: Henzinger, Monika H., and Jan Arne Telle. “Faster Algorithms for the Nonemptiness
    of Streett Automata and for Communication Protocol Pruning.” <i>5th Scandinavian
    Workshop on Algorithm Theory</i>, vol. 1097, Springer Nature, 1996, pp. 16–27,
    doi:<a href="https://doi.org/10.1007/3-540-61422-2_117">10.1007/3-540-61422-2_117</a>.
  short: M.H. Henzinger, J.A. Telle, in:, 5th Scandinavian Workshop on Algorithm Theory,
    Springer Nature, 1996, pp. 16–27.
conference:
  end_date: 1996-07-05
  location: Reykjavik, Iceland
  name: 'SWAT: Scandinavian Workshop on Algorithm Theory'
  start_date: 1996-07-03
date_created: 2022-08-11T13:42:42Z
date_published: 1996-07-01T00:00:00Z
date_updated: 2023-02-14T07:52:17Z
day: '01'
doi: 10.1007/3-540-61422-2_117
extern: '1'
intvolume: '      1097'
language:
- iso: eng
month: '07'
oa_version: None
page: 16–27
publication: 5th Scandinavian Workshop on Algorithm Theory
publication_identifier:
  eisbn:
  - '9783540685296'
  eissn:
  - 1611-3349
  isbn:
  - '9783540614227'
  issn:
  - 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Faster algorithms for the nonemptiness of streett automata and for communication
  protocol pruning
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1097
year: '1996'
...
---
_id: '11910'
abstract:
- lang: eng
  text: "We state a new sampling lemma and use it to improve the running time of dynamic
    graph algorithms.\r\n\r\nFor the dynamic connectivity problem the previously best
    randomized algorithm takes expected time O(log3 n) per update, amortized over
    Ω(m) updates. Using the new sampling lemma, we improve its running time to O(log2
    n). There exists a lower bound in the cell probe model for the time per operation
    of Ω(log n/ log log n) for this problem.\r\n\r\nSimilarly improved running times
    are achieved for 2-edge connectivity, k-weight minimum spanning tree, and bipartiteness."
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Monika H
  full_name: Henzinger, Monika H
  id: 540c9bbd-f2de-11ec-812d-d04a5be85630
  last_name: Henzinger
  orcid: 0000-0002-5008-6530
- first_name: Mikkel
  full_name: Thorup, Mikkel
  last_name: Thorup
citation:
  ama: 'Henzinger MH, Thorup M. Improved sampling with applications to dynamic graph
    algorithms. In: <i>23rd International Colloquium on Automata, Languages, and Programming</i>.
    Vol 1099. Springer Nature; 1996:290-299. doi:<a href="https://doi.org/10.1007/3-540-61440-0_136">10.1007/3-540-61440-0_136</a>'
  apa: 'Henzinger, M. H., &#38; Thorup, M. (1996). Improved sampling with applications
    to dynamic graph algorithms. In <i>23rd International Colloquium on Automata,
    Languages, and Programming</i> (Vol. 1099, pp. 290–299). Paderborn, Germany: Springer
    Nature. <a href="https://doi.org/10.1007/3-540-61440-0_136">https://doi.org/10.1007/3-540-61440-0_136</a>'
  chicago: Henzinger, Monika H, and Mikkel Thorup. “Improved Sampling with Applications
    to Dynamic Graph Algorithms.” In <i>23rd International Colloquium on Automata,
    Languages, and Programming</i>, 1099:290–99. Springer Nature, 1996. <a href="https://doi.org/10.1007/3-540-61440-0_136">https://doi.org/10.1007/3-540-61440-0_136</a>.
  ieee: M. H. Henzinger and M. Thorup, “Improved sampling with applications to dynamic
    graph algorithms,” in <i>23rd International Colloquium on Automata, Languages,
    and Programming</i>, Paderborn, Germany, 1996, vol. 1099, pp. 290–299.
  ista: 'Henzinger MH, Thorup M. 1996. Improved sampling with applications to dynamic
    graph algorithms. 23rd International Colloquium on Automata, Languages, and Programming.
    ICALP: International Colloquium on Automata, Languages, and Programming, LNCS,
    vol. 1099, 290–299.'
  mla: Henzinger, Monika H., and Mikkel Thorup. “Improved Sampling with Applications
    to Dynamic Graph Algorithms.” <i>23rd International Colloquium on Automata, Languages,
    and Programming</i>, vol. 1099, Springer Nature, 1996, pp. 290–99, doi:<a href="https://doi.org/10.1007/3-540-61440-0_136">10.1007/3-540-61440-0_136</a>.
  short: M.H. Henzinger, M. Thorup, in:, 23rd International Colloquium on Automata,
    Languages, and Programming, Springer Nature, 1996, pp. 290–299.
conference:
  end_date: 1996-07-12
  location: Paderborn, Germany
  name: 'ICALP: International Colloquium on Automata, Languages, and Programming'
  start_date: 1996-07-08
date_created: 2022-08-18T06:42:24Z
date_published: 1996-07-01T00:00:00Z
date_updated: 2023-02-14T07:57:14Z
day: '01'
doi: 10.1007/3-540-61440-0_136
extern: '1'
intvolume: '      1099'
language:
- iso: eng
month: '07'
oa_version: None
page: 290-299
publication: 23rd International Colloquium on Automata, Languages, and Programming
publication_identifier:
  eisbn:
  - '9783540685807'
  eissn:
  - 1611-3349
  isbn:
  - '9783540614401'
  issn:
  - 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Improved sampling with applications to dynamic graph algorithms
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1099
year: '1996'
...
---
_id: '11927'
abstract:
- lang: eng
  text: "We are given a set 7 = {Tl , Tz, . . . , Tk} of rooted binary trees, each
    Ti leaf-labeled by a subset L(x) c {1,2 )...) n}. IfT is a tree on {1,2, . . ,
    n}, we let T]L denote the subtree of T induced by the nodes of L and all their
    ancestors. The consensus tree problem asks whether there exists a tree T* such
    that for every I, T’ IC(Ti) is homeomorphic to Ti. We present algorithms which
    test if a given set of trees has a consensus tree and if so, construct one. The
    deterministic algorithm takes time min{O(mn’/‘), O(m + n2 logn)}, where m = Ci
    IZl and uses linear space. The randomized algorithm takes\r\ntime O(m log3 n)
    and uses linear space. The previous best for this problem was an 1981 O(mn) algorithm
    by Aho et al. Our faster deterministic algorithm uses a new efficient algorithm
    for the following interesting dynamic graph problem: Given a graph G with n nodes
    and m edges and a sequence of b batches of one or more edge deletions, then after
    each batch, either find a new component that has just been created or determine
    that there is no such component. For this\r\nproblem, we have a simple algorithm
    with running time O(n2 log n + be min{ n2, m log n}), where be is the number of
    batches which do not result in a new component. For our particular application,
    bc 5 1. If all edges are deleted, then the best previously known deterministic
    algorithm requires time O(mJ;ii) to solve this problem. computational evolutionary
    biology. The first application is in the problem of inferring consensus of trees
    when there can be disagreement[l6]. There have, been several models suggested
    for this problem[2, 3, 4, 8, ?, 11, 17, 181, of which one is called the Local
    Consensus Tree[l5]. The local consensus tree model presumes that the user provides
    a local consensus rule which determines the form of the output tree on (perhaps)
    each triple of leaves, and the objective is to determine whether a tree exists
    which is consistent with each of the constraints. We will show that we can construct
    the local consensus tree of k trees on n species in O(kn3) time, improving on
    the O(lcn3 + n”) running time if we use the Aho et al algorithm. The second application
    is a\r\nheuristic for constructing the maximum likelihood tree based upon combining
    solutions to small subproblems.\r\nThis is a simple and yet potentially significantly
    interesting approach to the evolutionary tree construction\r\nproblem. "
article_processing_charge: No
author:
- first_name: Monika H
  full_name: Henzinger, Monika H
  id: 540c9bbd-f2de-11ec-812d-d04a5be85630
  last_name: Henzinger
  orcid: 0000-0002-5008-6530
- first_name: Valerie
  full_name: King, Valerie
  last_name: King
- first_name: Tandy
  full_name: Warnow, Tandy
  last_name: Warnow
citation:
  ama: 'Henzinger MH, King V, Warnow T. Constructing a tree from homeomorphic subtrees,
    with applications to computational evolutionary biology. In: <i>7th Annual ACM-SIAM
    Symposium on Discrete Algorithms</i>. Society for Industrial and Applied Mathematics;
    1996:333-340.'
  apa: 'Henzinger, M. H., King, V., &#38; Warnow, T. (1996). Constructing a tree from
    homeomorphic subtrees, with applications to computational evolutionary biology.
    In <i>7th Annual ACM-SIAM Symposium on Discrete Algorithms</i> (pp. 333–340).
    Atlanta, GA, United States: Society for Industrial and Applied Mathematics.'
  chicago: Henzinger, Monika H, Valerie King, and Tandy Warnow. “Constructing a Tree
    from Homeomorphic Subtrees, with Applications to Computational Evolutionary Biology.”
    In <i>7th Annual ACM-SIAM Symposium on Discrete Algorithms</i>, 333–40. Society
    for Industrial and Applied Mathematics, 1996.
  ieee: M. H. Henzinger, V. King, and T. Warnow, “Constructing a tree from homeomorphic
    subtrees, with applications to computational evolutionary biology,” in <i>7th
    Annual ACM-SIAM Symposium on Discrete Algorithms</i>, Atlanta, GA, United States,
    1996, pp. 333–340.
  ista: 'Henzinger MH, King V, Warnow T. 1996. Constructing a tree from homeomorphic
    subtrees, with applications to computational evolutionary biology. 7th Annual
    ACM-SIAM Symposium on Discrete Algorithms. SODA: Symposium on Discrete Algorithms,
    333–340.'
  mla: Henzinger, Monika H., et al. “Constructing a Tree from Homeomorphic Subtrees,
    with Applications to Computational Evolutionary Biology.” <i>7th Annual ACM-SIAM
    Symposium on Discrete Algorithms</i>, Society for Industrial and Applied Mathematics,
    1996, pp. 333–40.
  short: M.H. Henzinger, V. King, T. Warnow, in:, 7th Annual ACM-SIAM Symposium on
    Discrete Algorithms, Society for Industrial and Applied Mathematics, 1996, pp.
    333–340.
conference:
  end_date: 1996-01-30
  location: Atlanta, GA, United States
  name: 'SODA: Symposium on Discrete Algorithms'
  start_date: 1996-01-28
date_created: 2022-08-19T06:57:47Z
date_published: 1996-01-28T00:00:00Z
date_updated: 2023-02-21T16:24:53Z
day: '28'
extern: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://dl.acm.org/doi/10.5555/313852.314080
month: '01'
oa: 1
oa_version: Published Version
page: 333 -340
publication: 7th Annual ACM-SIAM Symposium on Discrete Algorithms
publication_identifier:
  isbn:
  - '0898713668'
publication_status: published
publisher: Society for Industrial and Applied Mathematics
quality_controlled: '1'
related_material:
  record:
  - id: '11679'
    relation: later_version
    status: public
scopus_import: '1'
status: public
title: Constructing a tree from homeomorphic subtrees, with applications to computational
  evolutionary biology
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '1996'
...
---
_id: '3462'
article_processing_charge: No
article_type: original
author:
- first_name: Thorsten
  full_name: Melcher, Thorsten
  last_name: Melcher
- first_name: Jörg
  full_name: Geiger, Jörg
  last_name: Geiger
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
- first_name: Hannah
  full_name: Monyer, Hannah
  last_name: Monyer
citation:
  ama: Melcher T, Geiger J, Jonas PM, Monyer H. Analysis of molecular determinants
    in native AMPA receptors. <i>Neurochemistry International</i>. 1996;28(2):141-144.
    doi:<a href="https://doi.org/10.1016/0197-0186(95)00077-1">10.1016/0197-0186(95)00077-1</a>
  apa: Melcher, T., Geiger, J., Jonas, P. M., &#38; Monyer, H. (1996). Analysis of
    molecular determinants in native AMPA receptors. <i>Neurochemistry International</i>.
    Elsevier. <a href="https://doi.org/10.1016/0197-0186(95)00077-1">https://doi.org/10.1016/0197-0186(95)00077-1</a>
  chicago: Melcher, Thorsten, Jörg Geiger, Peter M Jonas, and Hannah Monyer. “Analysis
    of Molecular Determinants in Native AMPA Receptors.” <i>Neurochemistry International</i>.
    Elsevier, 1996. <a href="https://doi.org/10.1016/0197-0186(95)00077-1">https://doi.org/10.1016/0197-0186(95)00077-1</a>.
  ieee: T. Melcher, J. Geiger, P. M. Jonas, and H. Monyer, “Analysis of molecular
    determinants in native AMPA receptors,” <i>Neurochemistry International</i>, vol.
    28, no. 2. Elsevier, pp. 141–144, 1996.
  ista: Melcher T, Geiger J, Jonas PM, Monyer H. 1996. Analysis of molecular determinants
    in native AMPA receptors. Neurochemistry International. 28(2), 141–144.
  mla: Melcher, Thorsten, et al. “Analysis of Molecular Determinants in Native AMPA
    Receptors.” <i>Neurochemistry International</i>, vol. 28, no. 2, Elsevier, 1996,
    pp. 141–44, doi:<a href="https://doi.org/10.1016/0197-0186(95)00077-1">10.1016/0197-0186(95)00077-1</a>.
  short: T. Melcher, J. Geiger, P.M. Jonas, H. Monyer, Neurochemistry International
    28 (1996) 141–144.
date_created: 2018-12-11T12:03:27Z
date_published: 1996-02-01T00:00:00Z
date_updated: 2022-08-11T09:42:29Z
day: '01'
doi: 10.1016/0197-0186(95)00077-1
extern: '1'
external_id:
  pmid:
  - '8719701 '
intvolume: '        28'
issue: '2'
language:
- iso: eng
month: '02'
oa_version: None
page: 141 - 144
pmid: 1
publication: Neurochemistry International
publication_identifier:
  issn:
  - 0197-0186
publication_status: published
publisher: Elsevier
publist_id: '2925'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Analysis of molecular determinants in native AMPA receptors
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 28
year: '1996'
...
---
_id: '3553'
abstract:
- lang: eng
  text: Virtual environments open up new opportunities and challenges for geometric
    modeling systems. A general approach to geometric modeling suitable for the Cave
    Automatic Virtual Environment is described. The approach is based on alpha complexes,
    and some of its capabilities are demonstrated by applying it to the study of biomolecules.
acknowledgement: We thank Ernst Miicke and Michael Facello for their work on the Alpha
  shape library, and Nataraj Akkiraju for his work on the surface triangulation library.
  We thank NCSA for providing access to the CAVE.
article_processing_charge: No
author:
- first_name: Herbert
  full_name: Edelsbrunner, Herbert
  id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
  last_name: Edelsbrunner
  orcid: 0000-0002-9823-6833
- first_name: Ping
  full_name: Fu, Ping
  last_name: Fu
- first_name: Jiang
  full_name: Quian, Jiang
  last_name: Quian
citation:
  ama: 'Edelsbrunner H, Fu P, Quian J. Geometric modeling in CAVE. In: <i>Proceedings
    of the ACM Symposium on Virtual Reality Software and Technology</i>. ACM; 1996:35-41
    and-193-194. doi:<a href="https://doi.org/10.1145/3304181.3304190">10.1145/3304181.3304190</a>'
  apa: 'Edelsbrunner, H., Fu, P., &#38; Quian, J. (1996). Geometric modeling in CAVE.
    In <i>Proceedings of the ACM Symposium on Virtual Reality Software and Technology</i>
    (pp. 35-41 and-193–194). Hong Kong: ACM. <a href="https://doi.org/10.1145/3304181.3304190">https://doi.org/10.1145/3304181.3304190</a>'
  chicago: Edelsbrunner, Herbert, Ping Fu, and Jiang Quian. “Geometric Modeling in
    CAVE.” In <i>Proceedings of the ACM Symposium on Virtual Reality Software and
    Technology</i>, 35-41 and-193–94. ACM, 1996. <a href="https://doi.org/10.1145/3304181.3304190">https://doi.org/10.1145/3304181.3304190</a>.
  ieee: H. Edelsbrunner, P. Fu, and J. Quian, “Geometric modeling in CAVE,” in <i>Proceedings
    of the ACM Symposium on Virtual Reality Software and Technology</i>, Hong Kong,
    1996, pp. 35-41 and-193–194.
  ista: 'Edelsbrunner H, Fu P, Quian J. 1996. Geometric modeling in CAVE. Proceedings
    of the ACM Symposium on Virtual Reality Software and Technology. VRST: Symposium
    on Virtual Reality Software and Technology, 35-41 and-193–194.'
  mla: Edelsbrunner, Herbert, et al. “Geometric Modeling in CAVE.” <i>Proceedings
    of the ACM Symposium on Virtual Reality Software and Technology</i>, ACM, 1996,
    pp. 35-41 and-193–94, doi:<a href="https://doi.org/10.1145/3304181.3304190">10.1145/3304181.3304190</a>.
  short: H. Edelsbrunner, P. Fu, J. Quian, in:, Proceedings of the ACM Symposium on
    Virtual Reality Software and Technology, ACM, 1996, pp. 35-41 and-193–194.
conference:
  end_date: 1996-07-04
  location: Hong Kong
  name: 'VRST: Symposium on Virtual Reality Software and Technology'
  start_date: 1996-07-01
date_created: 2018-12-11T12:03:56Z
date_published: 1996-07-01T00:00:00Z
date_updated: 2022-08-10T13:42:02Z
day: '01'
doi: 10.1145/3304181.3304190
extern: '1'
language:
- iso: eng
month: '07'
oa_version: None
page: 35-41 and - 193-194
publication: Proceedings of the ACM Symposium on Virtual Reality Software and Technology
publication_identifier:
  isbn:
  - '9780897918251'
publication_status: published
publisher: ACM
publist_id: '2832'
quality_controlled: '1'
status: public
title: Geometric modeling in CAVE
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '1996'
...
---
_id: '3634'
abstract:
- lang: eng
  text: The evolutionary processes responsible for adaptation and speciation on islands
    differ in several ways from those on the mainland. Most attention has been given
    to the random genetic drift that arises when a population is founded from just
    a few colonizing genomes. Theoretical obstacles to 'founder effect speciation'
    are discussed, together with recent proposals for avoiding them. It is argued
    that although certain kinds of epistasis can facilitate the evolution of strong
    reproductive isolation, this favours divergence by selection as much as by random
    drift.
article_processing_charge: No
article_type: original
author:
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
- first_name: James
  full_name: Mallet, James
  last_name: Mallet
citation:
  ama: Barton NH, Mallet J. Natural selection and random genetic drift as causes of
    evolution on islands. <i>Philosophical Transactions of the Royal Society of London
    Series B, Biological Sciences</i>. 1996;351(1341):785-795. doi:<a href="https://doi.org/10.1098/rstb.1996.0073">10.1098/rstb.1996.0073</a>
  apa: Barton, N. H., &#38; Mallet, J. (1996). Natural selection and random genetic
    drift as causes of evolution on islands. <i>Philosophical Transactions of the
    Royal Society of London. Series B, Biological Sciences</i>. Royal Society of London.
    <a href="https://doi.org/10.1098/rstb.1996.0073">https://doi.org/10.1098/rstb.1996.0073</a>
  chicago: Barton, Nicholas H, and James Mallet. “Natural Selection and Random Genetic
    Drift as Causes of Evolution on Islands.” <i>Philosophical Transactions of the
    Royal Society of London. Series B, Biological Sciences</i>. Royal Society of London,
    1996. <a href="https://doi.org/10.1098/rstb.1996.0073">https://doi.org/10.1098/rstb.1996.0073</a>.
  ieee: N. H. Barton and J. Mallet, “Natural selection and random genetic drift as
    causes of evolution on islands,” <i>Philosophical Transactions of the Royal Society
    of London. Series B, Biological Sciences</i>, vol. 351, no. 1341. Royal Society
    of London, pp. 785–795, 1996.
  ista: Barton NH, Mallet J. 1996. Natural selection and random genetic drift as causes
    of evolution on islands. Philosophical Transactions of the Royal Society of London.
    Series B, Biological Sciences. 351(1341), 785–795.
  mla: Barton, Nicholas H., and James Mallet. “Natural Selection and Random Genetic
    Drift as Causes of Evolution on Islands.” <i>Philosophical Transactions of the
    Royal Society of London. Series B, Biological Sciences</i>, vol. 351, no. 1341,
    Royal Society of London, 1996, pp. 785–95, doi:<a href="https://doi.org/10.1098/rstb.1996.0073">10.1098/rstb.1996.0073</a>.
  short: N.H. Barton, J. Mallet, Philosophical Transactions of the Royal Society of
    London. Series B, Biological Sciences 351 (1996) 785–795.
date_created: 2018-12-11T12:04:21Z
date_published: 1996-06-29T00:00:00Z
date_updated: 2022-08-10T12:57:10Z
day: '29'
doi: 10.1098/rstb.1996.0073
extern: '1'
external_id:
  pmid:
  - '8693020'
intvolume: '       351'
issue: '1341'
language:
- iso: eng
month: '06'
oa_version: None
page: 785 - 795
pmid: 1
publication: Philosophical Transactions of the Royal Society of London. Series B,
  Biological Sciences
publication_identifier:
  issn:
  - 0962-8436
publication_status: published
publisher: Royal Society of London
publist_id: '2749'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Natural selection and random genetic drift as causes of evolution on islands
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 351
year: '1996'
...
---
_id: '3635'
abstract:
- lang: eng
  text: Experiments on Drosophila suggest that genetic recombination may result in
    lowered fitness of progeny (a 'recombination load'). This has been interpreted
    as evidence either for a direct effect of recombination on fitness, or for the
    maintenance of linkage disequilibria by epistatic selection. Here we show that
    such a recombination load is to be expected even if selection favours increased
    genetic recombination. This is because of the fact that, although a modifier may
    suffer an immediate loss of fitness if it increases recombination, it eventually
    becomes associated with a higher additive genetic variance in fitness, which allows
    a faster response to direction selection. This argument applies to mutation-selection
    balance with synergistic epistasis, directional selection on quantitative traits,
    and ectopic exchange among transposable elements. Further experiments are needed
    to determine whether the selection against recombination due to the immediate
    load is outweighed by the increased additive variance in fitness produced by recombination.
article_processing_charge: No
article_type: original
author:
- first_name: Brian
  full_name: Charlesworth, Brian
  last_name: Charlesworth
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
citation:
  ama: Charlesworth B, Barton NH. Recombination load associated with selection for
    increased recombination. <i>Genetical Research</i>. 1996;67(1):27-41. doi:<a href="https://doi.org/10.1017/S0016672300033450">10.1017/S0016672300033450</a>
  apa: Charlesworth, B., &#38; Barton, N. H. (1996). Recombination load associated
    with selection for increased recombination. <i>Genetical Research</i>. Cambridge
    University Press. <a href="https://doi.org/10.1017/S0016672300033450">https://doi.org/10.1017/S0016672300033450</a>
  chicago: Charlesworth, Brian, and Nicholas H Barton. “Recombination Load Associated
    with Selection for Increased Recombination.” <i>Genetical Research</i>. Cambridge
    University Press, 1996. <a href="https://doi.org/10.1017/S0016672300033450">https://doi.org/10.1017/S0016672300033450</a>.
  ieee: B. Charlesworth and N. H. Barton, “Recombination load associated with selection
    for increased recombination,” <i>Genetical Research</i>, vol. 67, no. 1. Cambridge
    University Press, pp. 27–41, 1996.
  ista: Charlesworth B, Barton NH. 1996. Recombination load associated with selection
    for increased recombination. Genetical Research. 67(1), 27–41.
  mla: Charlesworth, Brian, and Nicholas H. Barton. “Recombination Load Associated
    with Selection for Increased Recombination.” <i>Genetical Research</i>, vol. 67,
    no. 1, Cambridge University Press, 1996, pp. 27–41, doi:<a href="https://doi.org/10.1017/S0016672300033450">10.1017/S0016672300033450</a>.
  short: B. Charlesworth, N.H. Barton, Genetical Research 67 (1996) 27–41.
date_created: 2018-12-11T12:04:21Z
date_published: 1996-02-01T00:00:00Z
date_updated: 2022-08-10T12:38:51Z
day: '01'
doi: 10.1017/S0016672300033450
extern: '1'
external_id:
  pmid:
  - '8919888 '
intvolume: '        67'
issue: '1'
language:
- iso: eng
month: '02'
oa_version: None
page: 27 - 41
pmid: 1
publication: Genetical Research
publication_identifier:
  issn:
  - 0016-6723
publication_status: published
publisher: Cambridge University Press
publist_id: '2748'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Recombination load associated with selection for increased recombination
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 67
year: '1996'
...
---
_id: '3756'
abstract:
- lang: eng
  text: 'In many eukaryotic cells going through M-phase, a bipolar spindle is formed
    by microtubules nucleated from centrosomes. These microtubules, in addition to
    being `''captured” by kinetochores, may be stabilized by chromatin in two different
    ways: short-range stabilization effects may affect microtubules in close contact
    with the chromatin, while long-range stabilization effects may `''guide” microtubule
    growth towards the chromatin (e.g., by introducing a diffusive gradient of an
    enzymatic activity that affects microtubule assembly). Here, we use both meiotic
    and mitotic extracts from Xenopus laevis eggs to study microtubule aster formation
    and microtubule dynamics in the presence of chromatin. In `''low-speed” meiotic
    extracts, in the presence of salmon sperm chromatin, we find that short-range
    stabilization effects lead to a strong anisotropy of the microtubule asters. Analysis
    of the dynamic parameters of microtubule growth shows that this anisotropy arises
    from a decrease in the catastrophe frequency, an increase in the rescue frequency
    and a decrease in the growth velocity. In this system we also find evidence for
    long-range `''guidance” effects, which lead to a weak anisotropy of the asters.
    Statistically relevant results on these long-range effects are obtained in `''high-speed”
    mitotic extracts in the presence of artificially constructed chromatin stripes.
    We find that aster anisotropy is biased in the direction of the chromatin and
    that the catastrophe frequency is reduced in its vicinity. In this system we also
    find a surprising dependence of the catastrophe and the rescue frequencies on
    the length of microtubules nucleated from centrosomes: the catastrophe frequency
    increases and the rescue frequency decreases with microtubule length.'
acknowledgement: "We would like to thank T. Holy and T. Mitchison for providing us
  with centrosomes; M. Glotzer and T. Mitchison for giving us the plasmid for A90
  cyclin B; J. Stock and members of his laboratory for help with biochemical preparations;
  R. Zimmerman for help with the biotinylation of DNA; J. Shepard for help with the
  patterning of surfaces; D. Tsui for use\r\nof his clean room facility, and D. Fygenson,
  T. Holy, E. Karsenti, E. Kennedy, A. Levine, T. Mitchison, and G. Waters for valuable
  discussions, constant encouragement and technical help. This work was partially
  supported by the National Institutes of Health (Grant No. GM-50712) and the Human
  Frontier Science Program."
article_processing_charge: No
article_type: original
author:
- first_name: Marileen
  full_name: Dogterom, Marileen
  last_name: Dogterom
- first_name: M.
  full_name: Felix, M.
  last_name: Felix
- first_name: Calin C
  full_name: Guet, Calin C
  id: 47F8433E-F248-11E8-B48F-1D18A9856A87
  last_name: Guet
  orcid: 0000-0001-6220-2052
- first_name: Stanislas
  full_name: Leibler, Stanislas
  last_name: Leibler
citation:
  ama: 'Dogterom M, Felix M, Guet CC, Leibler S. Influence of M-phase chromatin on
    the anisotropy of microtubule asters. <i>Journal of Cell Biology</i>. 1996;133(1):125-140.
    doi:<a href="https://doi.org/doi: 10.1083/jcb.133.1.125 ">doi: 10.1083/jcb.133.1.125
    </a>'
  apa: 'Dogterom, M., Felix, M., Guet, C. C., &#38; Leibler, S. (1996). Influence
    of M-phase chromatin on the anisotropy of microtubule asters. <i>Journal of Cell
    Biology</i>. Rockefeller University Press. <a href="https://doi.org/doi: 10.1083/jcb.133.1.125
    ">https://doi.org/doi: 10.1083/jcb.133.1.125 </a>'
  chicago: 'Dogterom, Marileen, M. Felix, Calin C Guet, and Stanislas Leibler. “Influence
    of M-Phase Chromatin on the Anisotropy of Microtubule Asters.” <i>Journal of Cell
    Biology</i>. Rockefeller University Press, 1996. <a href="https://doi.org/doi:
    10.1083/jcb.133.1.125 ">https://doi.org/doi: 10.1083/jcb.133.1.125 </a>.'
  ieee: M. Dogterom, M. Felix, C. C. Guet, and S. Leibler, “Influence of M-phase chromatin
    on the anisotropy of microtubule asters,” <i>Journal of Cell Biology</i>, vol.
    133, no. 1. Rockefeller University Press, pp. 125–140, 1996.
  ista: Dogterom M, Felix M, Guet CC, Leibler S. 1996. Influence of M-phase chromatin
    on the anisotropy of microtubule asters. Journal of Cell Biology. 133(1), 125–140.
  mla: 'Dogterom, Marileen, et al. “Influence of M-Phase Chromatin on the Anisotropy
    of Microtubule Asters.” <i>Journal of Cell Biology</i>, vol. 133, no. 1, Rockefeller
    University Press, 1996, pp. 125–40, doi:<a href="https://doi.org/doi: 10.1083/jcb.133.1.125
    ">doi: 10.1083/jcb.133.1.125 </a>.'
  short: M. Dogterom, M. Felix, C.C. Guet, S. Leibler, Journal of Cell Biology 133
    (1996) 125–140.
date_created: 2018-12-11T12:05:00Z
date_published: 1996-01-01T00:00:00Z
date_updated: 2022-08-09T14:20:13Z
day: '01'
doi: 'doi: 10.1083/jcb.133.1.125 '
extern: '1'
external_id:
  pmid:
  - '8601601'
intvolume: '       133'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2120784/
month: '01'
oa: 1
oa_version: Published Version
page: 125 - 140
pmid: 1
publication: Journal of Cell Biology
publication_identifier:
  issn:
  - 0021-9525
publication_status: published
publisher: Rockefeller University Press
publist_id: '2473'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Influence of M-phase chromatin on the anisotropy of microtubule asters
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 133
year: '1996'
...
---
_id: '4024'
abstract:
- lang: eng
  text: We have developed general modeling software for a Cave Automatic Virtual Environment
    (CAVE); one of its applications is modeling 3D protein structures, generating
    both outside-in and inside-out views of geometric models. An advantage of the
    CAVE over other virtual environments is that multiple viewers can observe the
    same scene at the same time and place. Our software is scalable-from high-end
    virtual environments such as the CAVE, to mid-range immersive desktop systems,
    down to low-end graphics workstations. In the current configuration, a parallel
    Silicon Graphics Power Challenge supercomputer architecture performs the computationally
    intensive construction of surface patches remotely, and sends the results through
    the I-WAY (Information Wide Area Year) using VBNS (Very-high-Bandwidth Network
    Systems) to the graphics machines that drive the CAVE and our graphics visualization
    software, Valvis (Virtual ALpha shapes VISualizer).
article_processing_charge: No
article_type: original
author:
- first_name: Nataraj
  full_name: Akkiraju, Nataraj
  last_name: Akkiraju
- first_name: Herbert
  full_name: Edelsbrunner, Herbert
  id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
  last_name: Edelsbrunner
  orcid: 0000-0002-9823-6833
- first_name: Ping
  full_name: Fu, Ping
  last_name: Fu
- first_name: Jiang
  full_name: Qian, Jiang
  last_name: Qian
citation:
  ama: Akkiraju N, Edelsbrunner H, Fu P, Qian J. Viewing geometric protein structures
    from inside a CAVE. <i>IEEE Computer Graphics and Applications</i>. 1996;16(4):58-61.
    doi:<a href="https://doi.org/10.1109/38.511855">10.1109/38.511855</a>
  apa: Akkiraju, N., Edelsbrunner, H., Fu, P., &#38; Qian, J. (1996). Viewing geometric
    protein structures from inside a CAVE. <i>IEEE Computer Graphics and Applications</i>.
    IEEE. <a href="https://doi.org/10.1109/38.511855">https://doi.org/10.1109/38.511855</a>
  chicago: Akkiraju, Nataraj, Herbert Edelsbrunner, Ping Fu, and Jiang Qian. “Viewing
    Geometric Protein Structures from inside a CAVE.” <i>IEEE Computer Graphics and
    Applications</i>. IEEE, 1996. <a href="https://doi.org/10.1109/38.511855">https://doi.org/10.1109/38.511855</a>.
  ieee: N. Akkiraju, H. Edelsbrunner, P. Fu, and J. Qian, “Viewing geometric protein
    structures from inside a CAVE,” <i>IEEE Computer Graphics and Applications</i>,
    vol. 16, no. 4. IEEE, pp. 58–61, 1996.
  ista: Akkiraju N, Edelsbrunner H, Fu P, Qian J. 1996. Viewing geometric protein
    structures from inside a CAVE. IEEE Computer Graphics and Applications. 16(4),
    58–61.
  mla: Akkiraju, Nataraj, et al. “Viewing Geometric Protein Structures from inside
    a CAVE.” <i>IEEE Computer Graphics and Applications</i>, vol. 16, no. 4, IEEE,
    1996, pp. 58–61, doi:<a href="https://doi.org/10.1109/38.511855">10.1109/38.511855</a>.
  short: N. Akkiraju, H. Edelsbrunner, P. Fu, J. Qian, IEEE Computer Graphics and
    Applications 16 (1996) 58–61.
date_created: 2018-12-11T12:06:30Z
date_published: 1996-07-01T00:00:00Z
date_updated: 2022-08-09T13:32:21Z
day: '01'
doi: 10.1109/38.511855
extern: '1'
intvolume: '        16'
issue: '4'
language:
- iso: eng
month: '07'
oa_version: None
page: 58 - 61
publication: IEEE Computer Graphics and Applications
publication_identifier:
  issn:
  - 0018-9162
publication_status: published
publisher: IEEE
publist_id: '2101'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Viewing geometric protein structures from inside a CAVE
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 16
year: '1996'
...
---
_id: '4025'
abstract:
- lang: eng
  text: Questions of chemical reactivity can often be cast as questions of molecular
    geometry. Common geometric models for proteins and other molecules are the space-filling
    diagram, the solvent accessible surface and the molecular surface. In this paper
    we present a new approach to triangulating the surface of a molecule under the
    three models, which is fast, robust, and results in topologically correct triangulations.
    Our computations are based on a simplicial complex dual to the molecule models.
    All proposed algorithms are parallelizable.
acknowledgement: 'The research of both authors is partially supported by the Office
  of Naval Research. Herbert Edelsbrunner is also supported through the Alan T. Waterman
  award, grant CCR-9118874. '
article_processing_charge: No
article_type: original
author:
- first_name: Nataraj
  full_name: Akkiraju, Nataraj
  last_name: Akkiraju
- first_name: Herbert
  full_name: Edelsbrunner, Herbert
  id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
  last_name: Edelsbrunner
  orcid: 0000-0002-9823-6833
citation:
  ama: Akkiraju N, Edelsbrunner H. Triangulating the surface of a molecule. <i>Discrete
    Applied Mathematics</i>. 1996;71(1-3):5-22. doi:<a href="https://doi.org/10.1016/S0166-218X(96)00054-6">10.1016/S0166-218X(96)00054-6</a>
  apa: Akkiraju, N., &#38; Edelsbrunner, H. (1996). Triangulating the surface of a
    molecule. <i>Discrete Applied Mathematics</i>. Elsevier. <a href="https://doi.org/10.1016/S0166-218X(96)00054-6">https://doi.org/10.1016/S0166-218X(96)00054-6</a>
  chicago: Akkiraju, Nataraj, and Herbert Edelsbrunner. “Triangulating the Surface
    of a Molecule.” <i>Discrete Applied Mathematics</i>. Elsevier, 1996. <a href="https://doi.org/10.1016/S0166-218X(96)00054-6">https://doi.org/10.1016/S0166-218X(96)00054-6</a>.
  ieee: N. Akkiraju and H. Edelsbrunner, “Triangulating the surface of a molecule,”
    <i>Discrete Applied Mathematics</i>, vol. 71, no. 1–3. Elsevier, pp. 5–22, 1996.
  ista: Akkiraju N, Edelsbrunner H. 1996. Triangulating the surface of a molecule.
    Discrete Applied Mathematics. 71(1–3), 5–22.
  mla: Akkiraju, Nataraj, and Herbert Edelsbrunner. “Triangulating the Surface of
    a Molecule.” <i>Discrete Applied Mathematics</i>, vol. 71, no. 1–3, Elsevier,
    1996, pp. 5–22, doi:<a href="https://doi.org/10.1016/S0166-218X(96)00054-6">10.1016/S0166-218X(96)00054-6</a>.
  short: N. Akkiraju, H. Edelsbrunner, Discrete Applied Mathematics 71 (1996) 5–22.
date_created: 2018-12-11T12:06:30Z
date_published: 1996-12-05T00:00:00Z
date_updated: 2022-08-09T14:06:12Z
day: '05'
doi: 10.1016/S0166-218X(96)00054-6
extern: '1'
intvolume: '        71'
issue: 1-3
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.sciencedirect.com/science/article/pii/S0166218X96000546?via%3Dihub
month: '12'
oa: 1
oa_version: Published Version
page: 5 - 22
publication: Discrete Applied Mathematics
publication_identifier:
  issn:
  - 0166-218X
publication_status: published
publisher: Elsevier
publist_id: '2102'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Triangulating the surface of a molecule
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 71
year: '1996'
...
---
_id: '4026'
abstract:
- lang: eng
  text: A set of n weighted points in general position in R(d) defines a unique regular
    triangulation. This paper proves that if the points are added one by one, then
    flipping in a topological order will succeed in constructing this triangulation.
    If, in addition, the points are added in a random sequence and the history of
    the flips is used for locating the next point, then the algorithm takes expected
    time at most O(n log n + n(inverted left perpendicular d/2 inverted right perpendicular)).
    Under the assumption that the points and weights are independently and identically
    distributed, the expected running time is between proportional to and a factor
    log n more than the expected size of the regular triangulation. The expectation
    is over choosing the points and over independent coin-flips performed by the algorithm.
acknowledgement: National Science Foundation under Grant CCR-8921421, Alan T. Waterman
  award, Grant CCR-9118874.
article_processing_charge: No
article_type: original
author:
- first_name: Herbert
  full_name: Edelsbrunner, Herbert
  id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
  last_name: Edelsbrunner
  orcid: 0000-0002-9823-6833
- first_name: Nimish
  full_name: Shah, Nimish
  last_name: Shah
citation:
  ama: Edelsbrunner H, Shah N. Incremental topological flipping works for regular
    triangulations. <i>Algorithmica</i>. 1996;15(3):223-241. doi:<a href="https://doi.org/10.1007/BF01975867">10.1007/BF01975867</a>
  apa: Edelsbrunner, H., &#38; Shah, N. (1996). Incremental topological flipping works
    for regular triangulations. <i>Algorithmica</i>. Springer. <a href="https://doi.org/10.1007/BF01975867">https://doi.org/10.1007/BF01975867</a>
  chicago: Edelsbrunner, Herbert, and Nimish Shah. “Incremental Topological Flipping
    Works for Regular Triangulations.” <i>Algorithmica</i>. Springer, 1996. <a href="https://doi.org/10.1007/BF01975867">https://doi.org/10.1007/BF01975867</a>.
  ieee: H. Edelsbrunner and N. Shah, “Incremental topological flipping works for regular
    triangulations,” <i>Algorithmica</i>, vol. 15, no. 3. Springer, pp. 223–241, 1996.
  ista: Edelsbrunner H, Shah N. 1996. Incremental topological flipping works for regular
    triangulations. Algorithmica. 15(3), 223–241.
  mla: Edelsbrunner, Herbert, and Nimish Shah. “Incremental Topological Flipping Works
    for Regular Triangulations.” <i>Algorithmica</i>, vol. 15, no. 3, Springer, 1996,
    pp. 223–41, doi:<a href="https://doi.org/10.1007/BF01975867">10.1007/BF01975867</a>.
  short: H. Edelsbrunner, N. Shah, Algorithmica 15 (1996) 223–241.
date_created: 2018-12-11T12:06:31Z
date_published: 1996-03-01T00:00:00Z
date_updated: 2022-08-09T09:46:07Z
day: '01'
doi: 10.1007/BF01975867
extern: '1'
intvolume: '        15'
issue: '3'
language:
- iso: eng
month: '03'
oa_version: None
page: 223 - 241
publication: Algorithmica
publication_identifier:
  issn:
  - 0178-4617
publication_status: published
publisher: Springer
publist_id: '2099'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Incremental topological flipping works for regular triangulations
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 15
year: '1996'
...
---
_id: '4027'
abstract:
- lang: eng
  text: 'Questions about lines in space arise frequently as subproblems in three-dimensional
    computational geometry. In this paper we study a number of fundamental combinatorial
    and algorithmic problems involving arrangements of n lines in three-dimensional
    space. Our main results include: 1. A tight Θ(n2) bound on the maximum combinatorial
    description complexity of the set of all oriented lines that have specified orientations
    relative to the n given lines. 2. A similar bound of Θ(n3) for the complexity
    of the set of all lines passing above the n given lines. 3. A preprocessing procedure
    using O(n2+ε) time and storage, for any ε &gt; 0, that builds a structure supporting
    O(logn)-time queries for testing if a line lies above all the given lines. 4.
    An algorithm that tests the &quot;towering property&quot; in O(n4/3+ε) time, for
    any ε &gt; 0: do n given red lines lie all above n given blue lines? The tools
    used to obtain these and other results include Plücker coordinates for lines in
    space and ε-nets for various geometric range spaces.'
acknowledgement: Work on this paper by Bernard Chazelle has been supported by NSF
  Grant CCR-87-00917. Work on this paper by Herbert Edelsbrunner has been supported
  by NSF Grant CCR-87-14565. Work on this paper by Leonidas Guibas has been supported
  by grants from the Mitsubishi and Toshiba Corporations. Work on this paper by Micha
  Sharir has been supported by ONR Grant N00014-87-K-0129, by NSF Grants DCR-83-20085
  and CCR-89-01484, and by grants from the U.S.-Israeli Binational Science Foundation,
  the NCRD — the Israeli National Council for Research and Development, and the EMET
  Fund of the Israeli Academy of Sciences.
article_processing_charge: No
article_type: original
author:
- first_name: Bernard
  full_name: Chazelle, Bernard
  last_name: Chazelle
- first_name: Herbert
  full_name: Edelsbrunner, Herbert
  id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
  last_name: Edelsbrunner
  orcid: 0000-0002-9823-6833
- first_name: Leonidas
  full_name: Guibas, Leonidas
  last_name: Guibas
- first_name: Micha
  full_name: Sharir, Micha
  last_name: Sharir
- first_name: Jorge
  full_name: Stolfi, Jorge
  last_name: Stolfi
citation:
  ama: 'Chazelle B, Edelsbrunner H, Guibas L, Sharir M, Stolfi J. Lines in space:
    Combinatorics and algorithms. <i>Algorithmica</i>. 1996;15(5):428-447. doi:<a
    href="https://doi.org/10.1007/BF01955043">10.1007/BF01955043</a>'
  apa: 'Chazelle, B., Edelsbrunner, H., Guibas, L., Sharir, M., &#38; Stolfi, J. (1996).
    Lines in space: Combinatorics and algorithms. <i>Algorithmica</i>. Springer. <a
    href="https://doi.org/10.1007/BF01955043">https://doi.org/10.1007/BF01955043</a>'
  chicago: 'Chazelle, Bernard, Herbert Edelsbrunner, Leonidas Guibas, Micha Sharir,
    and Jorge Stolfi. “Lines in Space: Combinatorics and Algorithms.” <i>Algorithmica</i>.
    Springer, 1996. <a href="https://doi.org/10.1007/BF01955043">https://doi.org/10.1007/BF01955043</a>.'
  ieee: 'B. Chazelle, H. Edelsbrunner, L. Guibas, M. Sharir, and J. Stolfi, “Lines
    in space: Combinatorics and algorithms,” <i>Algorithmica</i>, vol. 15, no. 5.
    Springer, pp. 428–447, 1996.'
  ista: 'Chazelle B, Edelsbrunner H, Guibas L, Sharir M, Stolfi J. 1996. Lines in
    space: Combinatorics and algorithms. Algorithmica. 15(5), 428–447.'
  mla: 'Chazelle, Bernard, et al. “Lines in Space: Combinatorics and Algorithms.”
    <i>Algorithmica</i>, vol. 15, no. 5, Springer, 1996, pp. 428–47, doi:<a href="https://doi.org/10.1007/BF01955043">10.1007/BF01955043</a>.'
  short: B. Chazelle, H. Edelsbrunner, L. Guibas, M. Sharir, J. Stolfi, Algorithmica
    15 (1996) 428–447.
date_created: 2018-12-11T12:06:31Z
date_published: 1996-05-01T00:00:00Z
date_updated: 2022-08-09T09:55:46Z
day: '01'
doi: 10.1007/BF01955043
extern: '1'
intvolume: '        15'
issue: '5'
language:
- iso: eng
month: '05'
oa_version: None
page: 428 - 447
publication: Algorithmica
publication_identifier:
  issn:
  - 0178-4617
publication_status: published
publisher: Springer
publist_id: '2100'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Lines in space: Combinatorics and algorithms'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 15
year: '1996'
...
---
_id: '4030'
acknowledgement: article M-Pos412
article_processing_charge: No
author:
- first_name: Jie
  full_name: Liang, Jie
  last_name: Liang
- first_name: Herbert
  full_name: Edelsbrunner, Herbert
  id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
  last_name: Edelsbrunner
  orcid: 0000-0002-9823-6833
- first_name: Shankar
  full_name: Subramaniam, Shankar
  last_name: Subramaniam
citation:
  ama: Liang J, Edelsbrunner H, Subramaniam S. <i>Effects of Molecular Shape Representations
    on Boundary Element Method for Protein Electrostatics Computations</i>. Vol 70.
    Cell Press; 1996:A224-A224. doi:<a href="https://doi.org/10.1016/S0006-3495(96)79664-9">10.1016/S0006-3495(96)79664-9</a>
  apa: Liang, J., Edelsbrunner, H., &#38; Subramaniam, S. (1996). <i>Effects of molecular
    shape representations on boundary element method for protein electrostatics computations</i>.
    <i>Fortieth Annual Meeting</i> (Vol. 70, pp. A224–A224). Cell Press. <a href="https://doi.org/10.1016/S0006-3495(96)79664-9">https://doi.org/10.1016/S0006-3495(96)79664-9</a>
  chicago: Liang, Jie, Herbert Edelsbrunner, and Shankar Subramaniam. <i>Effects of
    Molecular Shape Representations on Boundary Element Method for Protein Electrostatics
    Computations</i>. <i>Fortieth Annual Meeting</i>. Vol. 70. Cell Press, 1996. <a
    href="https://doi.org/10.1016/S0006-3495(96)79664-9">https://doi.org/10.1016/S0006-3495(96)79664-9</a>.
  ieee: J. Liang, H. Edelsbrunner, and S. Subramaniam, <i>Effects of molecular shape
    representations on boundary element method for protein electrostatics computations</i>,
    vol. 70, no. 2, Part 2. Cell Press, 1996, pp. A224–A224.
  ista: Liang J, Edelsbrunner H, Subramaniam S. 1996. Effects of molecular shape representations
    on boundary element method for protein electrostatics computations, Cell Press,p.
  mla: Liang, Jie, et al. “Effects of Molecular Shape Representations on Boundary
    Element Method for Protein Electrostatics Computations.” <i>Fortieth Annual Meeting</i>,
    vol. 70, no. 2, Part 2, Cell Press, 1996, pp. A224–A224, doi:<a href="https://doi.org/10.1016/S0006-3495(96)79664-9">10.1016/S0006-3495(96)79664-9</a>.
  short: J. Liang, H. Edelsbrunner, S. Subramaniam, Effects of Molecular Shape Representations
    on Boundary Element Method for Protein Electrostatics Computations, Cell Press,
    1996.
date_created: 2018-12-11T12:06:32Z
date_published: 1996-02-19T00:00:00Z
date_updated: 2022-08-08T10:22:38Z
day: '19'
doi: 10.1016/S0006-3495(96)79664-9
extern: '1'
intvolume: '        70'
issue: 2, Part 2
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.sciencedirect.com/science/article/pii/S0006349596796649?via%3Dihub
month: '02'
oa: 1
oa_version: None
page: A224 - A224
publication: Fortieth Annual Meeting
publication_status: published
publisher: Cell Press
publist_id: '2097'
status: public
title: Effects of molecular shape representations on boundary element method for protein
  electrostatics computations
type: conference_poster
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 70
year: '1996'
...
---
_id: '4031'
acknowledgement: article W-AM-L6
article_processing_charge: No
author:
- first_name: Jie
  full_name: Liang, Jie
  last_name: Liang
- first_name: Herbert
  full_name: Edelsbrunner, Herbert
  id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
  last_name: Edelsbrunner
  orcid: 0000-0002-9823-6833
- first_name: Sudhakar
  full_name: Pamidghantam, Sudhakar
  last_name: Pamidghantam
- first_name: Shankar
  full_name: Subramaniam, Shankar
  last_name: Subramaniam
citation:
  ama: 'Liang J, Edelsbrunner H, Pamidghantam S, Subramaniam S. <i>Analytical Method
    for Molecular Shapes: Area, Volume, Cavities, Interface and Pockets</i>. Vol 70.
    Cell Press; 1996:A377-A377. doi:<a href="https://doi.org/10.1016/S0006-3495(96)79670-4">10.1016/S0006-3495(96)79670-4</a>'
  apa: 'Liang, J., Edelsbrunner, H., Pamidghantam, S., &#38; Subramaniam, S. (1996).
    <i>Analytical method for molecular shapes: Area, volume, cavities, interface and
    pockets</i>. <i>Fortieth Annual Meeting</i> (Vol. 70, pp. A377–A377). Cell Press.
    <a href="https://doi.org/10.1016/S0006-3495(96)79670-4">https://doi.org/10.1016/S0006-3495(96)79670-4</a>'
  chicago: 'Liang, Jie, Herbert Edelsbrunner, Sudhakar Pamidghantam, and Shankar Subramaniam.
    <i>Analytical Method for Molecular Shapes: Area, Volume, Cavities, Interface and
    Pockets</i>. <i>Fortieth Annual Meeting</i>. Vol. 70. Cell Press, 1996. <a href="https://doi.org/10.1016/S0006-3495(96)79670-4">https://doi.org/10.1016/S0006-3495(96)79670-4</a>.'
  ieee: 'J. Liang, H. Edelsbrunner, S. Pamidghantam, and S. Subramaniam, <i>Analytical
    method for molecular shapes: Area, volume, cavities, interface and pockets</i>,
    vol. 70, no. 2, Part 2. Cell Press, 1996, pp. A377–A377.'
  ista: 'Liang J, Edelsbrunner H, Pamidghantam S, Subramaniam S. 1996. Analytical
    method for molecular shapes: Area, volume, cavities, interface and pockets, Cell
    Press,p.'
  mla: 'Liang, Jie, et al. “Analytical Method for Molecular Shapes: Area, Volume,
    Cavities, Interface and Pockets.” <i>Fortieth Annual Meeting</i>, vol. 70, no.
    2, Part 2, Cell Press, 1996, pp. A377–A377, doi:<a href="https://doi.org/10.1016/S0006-3495(96)79670-4">10.1016/S0006-3495(96)79670-4</a>.'
  short: 'J. Liang, H. Edelsbrunner, S. Pamidghantam, S. Subramaniam, Analytical Method
    for Molecular Shapes: Area, Volume, Cavities, Interface and Pockets, Cell Press,
    1996.'
date_created: 2018-12-11T12:06:32Z
date_published: 1996-02-21T00:00:00Z
date_updated: 2022-08-08T10:21:56Z
day: '21'
doi: 10.1016/S0006-3495(96)79670-4
extern: '1'
intvolume: '        70'
issue: 2, Part 2
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.sciencedirect.com/science/article/pii/S0006349596796704?via%3Dihub
month: '02'
oa: 1
oa_version: None
page: A377 - A377
publication: Fortieth Annual Meeting
publication_status: published
publisher: Cell Press
publist_id: '2098'
status: public
title: 'Analytical method for molecular shapes: Area, volume, cavities, interface
  and pockets'
type: conference_poster
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 70
year: '1996'
...
---
_id: '4142'
abstract:
- lang: eng
  text: 'Mutations giving rise to anatomical defects in the inner ear have been isolated
    in a large scale screen for mutations causing visible abnormalities in the zebrafish
    embryo (Haffter, P., Granato, M., Brand, M. et al. (1996) Development 123, 1-36).
    58 mutants have been classified as having a primary ear phenotype; these fall
    into several phenotypic classes, affecting presence or size of the otoliths, size
    and shape of the otic vesicle and formation of the semicircular canals, and define
    at least 20 complementation groups. Mutations in seven genes cause loss of one
    or both otoliths, but do not appear to affect development of other structures
    within the ear. Mutations in seven genes affect morphology and patterning of the
    inner ear epithelium, including formation of the semicircular canals and, in some,
    development of sensory patches (maculae and cristae). Within this class, dog-eared
    mutants show abnormal development of semicircular canals and lack cristae within
    the ear, while in van gogh, semicircular canals fail to form altogether, resulting
    in a tiny otic vesicle containing a single sensory patch. Both these mutants show
    defects in the expression of homeobox genes within the otic vesicle. In a further
    class of mutants, ear size is affected while patterning appears to be relatively
    normal; mutations in three genes cause expansion of the otic vesicle, while in
    little ears and microtic, the ear is abnormally small, but still contains all
    five sensory patches, as in the wild type. Many of the ear and otolith mutants
    show an expected behavioural phenotype: embryos fail to balance correctly, and
    may swim on their sides, upside down, or in circles. Several mutants with similar
    balance defects have also been isolated that have no obvious structural ear defect,
    but that may include mutants with vestibular dysfunction of the inner ear (Granato,
    M., van Eeden, F. J. M., Schach, U. et al. (1996) Development, 123, 399-413,).
    Mutations in 19 genes causing primary defects in other structures also show an
    ear defect. In particular, ear phenotypes are often found in conjunction with
    defects of neural crest derivatives (pigment cells and/or cartilaginous elements
    of the jaw). At least one mutant, dog-eared, shows defects in both the ear and
    another placodally derived sensory system, the lateral line, while hypersensitive
    mutants have additional trunk lateral line organs.'
acknowledgement: T. T. W. thanks all members of the Tübingen fish and fly groups for
  their hospitality and generosity during her visits to the laboratory. We thank Julian
  Lewis, in whose laboratory much of this work was carried out, for many helpful discussions
  and suggestions, Catherine Haddon for advice on wild-type ear development and techniques,
  and Stephen Massey for fish husbandry in Oxford. We are grateful to Julian Lewis,
  Catherine Haddon, Nick Monk and Patrick Blader for comments on the manuscript, and
  to Trevor Jowett, Tom Schilling,Eric Weinberg and Monte Westerfield for providing
  cDNAs. We also thank Jarema Malicki and Wolfgang Driever for making some of the
  Boston otolith mutants available before publication. T. T. W. thanks the EMBO (ASTF
  7668; ASTF 7918), the Imperial Cancer Research Fund and the Wellcome Trust (03643/Z/92)
  for support.
article_processing_charge: No
article_type: original
author:
- first_name: Tanya
  full_name: Whitfield, Tanya
  last_name: Whitfield
- first_name: Michael
  full_name: Granato, Michael
  last_name: Granato
- first_name: Fredericus
  full_name: Van Eeden, Fredericus
  last_name: Van Eeden
- first_name: Ursula
  full_name: Schach, Ursula
  last_name: Schach
- first_name: Michael
  full_name: Brand, Michael
  last_name: Brand
- first_name: Makoto
  full_name: Furutani Seiki, Makoto
  last_name: Furutani Seiki
- first_name: Pascal
  full_name: Haffter, Pascal
  last_name: Haffter
- first_name: Matthias
  full_name: Hammerschmidt, Matthias
  last_name: Hammerschmidt
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
- first_name: Yunjin
  full_name: Jiang, Yunjin
  last_name: Jiang
- first_name: Donald
  full_name: Kane, Donald
  last_name: Kane
- first_name: Robert
  full_name: Kelsh, Robert
  last_name: Kelsh
- first_name: Mary
  full_name: Mullins, Mary
  last_name: Mullins
- first_name: Jörg
  full_name: Odenthal, Jörg
  last_name: Odenthal
- first_name: Christiane
  full_name: Nüsslein Volhard, Christiane
  last_name: Nüsslein Volhard
citation:
  ama: Whitfield T, Granato M, Van Eeden F, et al. Mutations affecting development
    of the zebrafish inner ear and lateral line. <i>Development</i>. 1996;123:241-254.
    doi:<a href="https://doi.org/10.1242/dev.123.1.241">10.1242/dev.123.1.241</a>
  apa: Whitfield, T., Granato, M., Van Eeden, F., Schach, U., Brand, M., Furutani
    Seiki, M., … Nüsslein Volhard, C. (1996). Mutations affecting development of the
    zebrafish inner ear and lateral line. <i>Development</i>. Company of Biologists.
    <a href="https://doi.org/10.1242/dev.123.1.241">https://doi.org/10.1242/dev.123.1.241</a>
  chicago: Whitfield, Tanya, Michael Granato, Fredericus Van Eeden, Ursula Schach,
    Michael Brand, Makoto Furutani Seiki, Pascal Haffter, et al. “Mutations Affecting
    Development of the Zebrafish Inner Ear and Lateral Line.” <i>Development</i>.
    Company of Biologists, 1996. <a href="https://doi.org/10.1242/dev.123.1.241">https://doi.org/10.1242/dev.123.1.241</a>.
  ieee: T. Whitfield <i>et al.</i>, “Mutations affecting development of the zebrafish
    inner ear and lateral line,” <i>Development</i>, vol. 123. Company of Biologists,
    pp. 241–254, 1996.
  ista: Whitfield T, Granato M, Van Eeden F, Schach U, Brand M, Furutani Seiki M,
    Haffter P, Hammerschmidt M, Heisenberg C-PJ, Jiang Y, Kane D, Kelsh R, Mullins
    M, Odenthal J, Nüsslein Volhard C. 1996. Mutations affecting development of the
    zebrafish inner ear and lateral line. Development. 123, 241–254.
  mla: Whitfield, Tanya, et al. “Mutations Affecting Development of the Zebrafish
    Inner Ear and Lateral Line.” <i>Development</i>, vol. 123, Company of Biologists,
    1996, pp. 241–54, doi:<a href="https://doi.org/10.1242/dev.123.1.241">10.1242/dev.123.1.241</a>.
  short: T. Whitfield, M. Granato, F. Van Eeden, U. Schach, M. Brand, M. Furutani
    Seiki, P. Haffter, M. Hammerschmidt, C.-P.J. Heisenberg, Y. Jiang, D. Kane, R.
    Kelsh, M. Mullins, J. Odenthal, C. Nüsslein Volhard, Development 123 (1996) 241–254.
date_created: 2018-12-11T12:07:11Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-08T08:45:59Z
day: '01'
doi: 10.1242/dev.123.1.241
extern: '1'
external_id:
  pmid:
  - '9007244'
intvolume: '       123'
language:
- iso: eng
month: '12'
oa_version: None
page: 241 - 254
pmid: 1
publication: Development
publication_identifier:
  issn:
  - 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1979'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mutations affecting development of the zebrafish inner ear and lateral line
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
