---
_id: '2488'
abstract:
- lang: eng
text: Substance P receptor-expressing neurons in the rat cerebral neocortex were
examined by single- and double-immunolabeling methods with an affinity-purified
specific antibody to substance P receptor. Substance P receptor immunoreactivity
was observed exclusively in non-pyramidal neurons. About a quarter of these substance
P receptor-positive neocortical neurons showed intense immunoreactivity, and the
other three quarters displayed weak substance P receptor immunoreactivity. The
neurons showing intense substance P receptor immunoreactivity were large multipolar
cells with a few long aspiny or sparsely-spiny dendrites, and were scattered throughout
the neocortical layers except for layer I, and also in the underlying white matter.
The weakly immunoreactive neurons were medium-sized multipolar cells with oval
to round somata and aspiny varicose dendrites, and were distributed in all cortical
layers with a bias to layers II-III and the superficial part of layer V. The double-immunofluorescence
study revealed that almost all substance P receptor-positive neurons were immunoreactive
for GABA, but negative for glutaminase. Substance P receptor immunoreactivity
in GABAergic neocortical neurons were further examined by the double-immunofluorescence
method with antibodies to markers for subgroups of GABAergic neurons. Somatostatin
immunoreactivity was found in 89% of neurons with intense substance P receptor
immunoreactivity, and in 1.5% of neurons with weak substance P receptor immunoreactivity.
Neuropeptide Y immunoreactivity was also observed in 92% of neurons with intense
immunoreactivity for substance P receptor, and in 1.6% of neurons with weak immunoreactivity
for substance P receptor. In contrast, parvalbumin immunoreactivity was seen in
1.3% of neurons with intense substance P receptor immunoreactivity, and in 59%
of weak substance P receptor immunoreactivity. Calbindin D28k immunoreactivity
was found in 12 and 19% of neurons, respectively, with weak and intense immunoreactivities
for substance P receptor. Virtually no cells showing substance P receptor immunoreactivity
displayed immunoreactivity for vasoactive intestinal polypeptide or choline acetyltransferase.
These results indicate that the neocortical neurons expressing substance P receptor
constitute a subpopulation of GABAergic non-pyramidal cells, and are segregated
into neurons with intense immunoreactivity and those with weak immunoreactivity
for substance P receptor; the vast majority of neurons with intense substance
P receptor immunoreactivity contain somatostatin and neuropeptide Y, and the majority
of neurons with weak substance P receptor immunoreactivity have parvalbumin.
acknowledgement: We are grateful for photographic help of Mr A. Uesugi, and the support
of Drs S. Fukuchi, T. Fukuda, R. Hayashi, M. Katsurada, Y. Kitani, K. Kumagai, H.
Kuroda, H. Matsubara, H. Matsushima, C. Minakuchi, M. Nishio, G. Niwa, H. Ckla,
M. Ohbayashi, S. Ohbayashi, H. Ohtsuka, S. Tamaki, E. Watanabe, K. Yoshino and Y.
Yoshino. This work was supported in part by Grants-in-Aid for Scientific Research
on Priority Areas 05248207 and 05267104, and Scientific Research (B) 05454658 and
(C) 05680658 from the Ministry of Education, Science and Culture of Japan.
article_processing_charge: No
article_type: original
author:
- first_name: Takeshi
full_name: Kaneko, Takeshi
last_name: Kaneko
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Kaneko T, Shigemoto R, Nakanishi S, Mizuno N. Morphological and chemical characteristics
of substance P receptor immunoreactive neurons in the rat neocortex. Neuroscience.
1994;60(1):199-211. doi:10.1016/0306-4522(94)90215-1
apa: Kaneko, T., Shigemoto, R., Nakanishi, S., & Mizuno, N. (1994). Morphological
and chemical characteristics of substance P receptor immunoreactive neurons in
the rat neocortex. Neuroscience. Elsevier. https://doi.org/10.1016/0306-4522(94)90215-1
chicago: Kaneko, Takeshi, Ryuichi Shigemoto, Shigetada Nakanishi, and Noboru Mizuno.
“Morphological and Chemical Characteristics of Substance P Receptor Immunoreactive
Neurons in the Rat Neocortex.” Neuroscience. Elsevier, 1994. https://doi.org/10.1016/0306-4522(94)90215-1.
ieee: T. Kaneko, R. Shigemoto, S. Nakanishi, and N. Mizuno, “Morphological and chemical
characteristics of substance P receptor immunoreactive neurons in the rat neocortex,”
Neuroscience, vol. 60, no. 1. Elsevier, pp. 199–211, 1994.
ista: Kaneko T, Shigemoto R, Nakanishi S, Mizuno N. 1994. Morphological and chemical
characteristics of substance P receptor immunoreactive neurons in the rat neocortex.
Neuroscience. 60(1), 199–211.
mla: Kaneko, Takeshi, et al. “Morphological and Chemical Characteristics of Substance
P Receptor Immunoreactive Neurons in the Rat Neocortex.” Neuroscience,
vol. 60, no. 1, Elsevier, 1994, pp. 199–211, doi:10.1016/0306-4522(94)90215-1.
short: T. Kaneko, R. Shigemoto, S. Nakanishi, N. Mizuno, Neuroscience 60 (1994)
199–211.
date_created: 2018-12-11T11:57:58Z
date_published: 1994-05-01T00:00:00Z
date_updated: 2022-06-09T12:22:16Z
day: '01'
doi: 10.1016/0306-4522(94)90215-1
extern: '1'
external_id:
pmid:
- '8052413'
intvolume: ' 60'
issue: '1'
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/0306452294902151?via%3Dihub
month: '05'
oa_version: None
page: 199 - 211
pmid: 1
publication: Neuroscience
publication_identifier:
issn:
- 0306-4522
publication_status: published
publisher: Elsevier
publist_id: '4413'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Morphological and chemical characteristics of substance P receptor immunoreactive
neurons in the rat neocortex
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 60
year: '1994'
...
---
_id: '2489'
abstract:
- lang: eng
text: 'Five N-methyl-D-aspartate (NMDA) receptor subunits have been identified thus
far: NR1, NR2A, NR2B, NR2C, and NR2D. Here, we have analyzed the expression patterns
of mRNAs for the NMDA receptor subunits in the developing and adult rats by in
situ hybridization. The developmental changes of the expression patterns were
most salient in the cerebellum. In the external granular layer, hybridization
signals of mRNAs for NR1, NR2A, NR2B, and NR2C appeared by postnatal day 3, but
no NR2D mRNA was expressed at any developmental stage examined. The NR1 mRNA was
expressed in all cerebellar neurons at all developmental stages examined. The
signals for the NR2A mRNA appeared in Purkinje cells and granule cells during
the second postnatal week. The signals for the NR2B mRNA in granule cells were
seen transiently during the first 2 weeks after birth. The signals for NR2C mRNA
appeared in granule cells and glial cells during the second postnatal week. The
signals for NR2D mRNA appeared transiently in Purkinje cells during the first
8 postnatal days; in adult rats, these were seen in stellate and Golgi cells.
In the cerebellar nuclei, mRNAs for NR1, NR2A, NR2B, and NR2D were more or less
expressed on postnatal day 0, while expression signals for the NR2C mRNA were
first detected in postnatal day 14. Thus, the most conspicuous changes of expression
patterns were observed in the cerebellar cortex during the first 2 weeks after
birth, when development and maturation of the cerebellum proceed most rapidly.'
acknowledgement: We are grateful to Mr. Akira Uesugi for photographic help and
for the support of Drs. Satoru Fukuchi, Toshio Fukuda, Ritsu Hayashi, Mizuho Katsurada,
Yutaka Kitani, Keiko Kumagai, Toshihiko Kuroda, Hiroshi Matsubara, Hiroshi Matsushima,
Chisato Minakuchi, Masatoshi Nishio, Gonpei Niwa Hajime Oda, Masahiko Ohbayashi,
Sei-ichi Ohbayashi, Hiroyasu Ohtsuka, Shigeo Tamaki, Eizo Watan- abe, Kazuo Yoshino,
and Toshiaki Yoshino. This work was supported in part by research grants from the
Ministry of Education, Science and Culture of Japan.
article_processing_charge: No
article_type: original
author:
- first_name: Chihiro
full_name: Akazawa, Chihiro
last_name: Akazawa
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Yasumasa
full_name: Bessho, Yasumasa
last_name: Bessho
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Akazawa C, Shigemoto R, Bessho Y, Nakanishi S, Mizuno N. Differential expression
of five N-methyl-D-aspartate receptor subunit mRNAs in the cerebellum of developing
and adult rats. Journal of Comparative Neurology. 1994;347(1):150-160.
doi:10.1002/cne.903470112
apa: Akazawa, C., Shigemoto, R., Bessho, Y., Nakanishi, S., & Mizuno, N. (1994).
Differential expression of five N-methyl-D-aspartate receptor subunit mRNAs in
the cerebellum of developing and adult rats. Journal of Comparative Neurology.
Wiley-Blackwell. https://doi.org/10.1002/cne.903470112
chicago: Akazawa, Chihiro, Ryuichi Shigemoto, Yasumasa Bessho, Shigetada Nakanishi,
and Noboru Mizuno. “Differential Expression of Five N-Methyl-D-Aspartate Receptor
Subunit MRNAs in the Cerebellum of Developing and Adult Rats.” Journal of Comparative
Neurology. Wiley-Blackwell, 1994. https://doi.org/10.1002/cne.903470112.
ieee: C. Akazawa, R. Shigemoto, Y. Bessho, S. Nakanishi, and N. Mizuno, “Differential
expression of five N-methyl-D-aspartate receptor subunit mRNAs in the cerebellum
of developing and adult rats,” Journal of Comparative Neurology, vol. 347,
no. 1. Wiley-Blackwell, pp. 150–160, 1994.
ista: Akazawa C, Shigemoto R, Bessho Y, Nakanishi S, Mizuno N. 1994. Differential
expression of five N-methyl-D-aspartate receptor subunit mRNAs in the cerebellum
of developing and adult rats. Journal of Comparative Neurology. 347(1), 150–160.
mla: Akazawa, Chihiro, et al. “Differential Expression of Five N-Methyl-D-Aspartate
Receptor Subunit MRNAs in the Cerebellum of Developing and Adult Rats.” Journal
of Comparative Neurology, vol. 347, no. 1, Wiley-Blackwell, 1994, pp. 150–60,
doi:10.1002/cne.903470112.
short: C. Akazawa, R. Shigemoto, Y. Bessho, S. Nakanishi, N. Mizuno, Journal of
Comparative Neurology 347 (1994) 150–160.
date_created: 2018-12-11T11:57:58Z
date_published: 1994-09-01T00:00:00Z
date_updated: 2022-06-09T12:11:20Z
day: '01'
doi: 10.1002/cne.903470112
extern: '1'
external_id:
pmid:
- '7798379'
intvolume: ' 347'
issue: '1'
language:
- iso: eng
main_file_link:
- url: https://onlinelibrary.wiley.com/doi/10.1002/cne.903470112
month: '09'
oa_version: None
page: 150 - 160
pmid: 1
publication: Journal of Comparative Neurology
publication_identifier:
issn:
- 0021-9967
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4412'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Differential expression of five N-methyl-D-aspartate receptor subunit mRNAs
in the cerebellum of developing and adult rats
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 347
year: '1994'
...
---
_id: '2490'
abstract:
- lang: eng
text: Distribution of the messenger RNA for the prostaglandin E receptor subtype
EP3 was investigated by in situ hybridization in the nervous system of the mouse.
The hybridization signals for EP3 were widely distributed in the brain and sensory
ganglia and specifically localized to neurons. In the dorsal root and trigeminal
ganglia, about half of the neurons were labeled intensely. In the brain, intensely
labeled neurons were found in Ammon's horn, the preoptic nuclei, lateral hypothalamic
area, dorsomedial hypothalamic nucleus, lateral mammillary nucleus, entopeduncular
nucleus, substantia nigra pars compacta, locus coeruleus and raphe nuclei. Moderately
labeled neurons were seen in the mitral cell layer of the main olfactory bulb,
layer V of the entorhinal and parasubicular cortices, layers V and VI of the cerebral
neocortex, nuclei of the diagonal band, magnocellular preoptic nucleus, globus
pallidus and lateral parabrachial nucleus. In the thalamus, moderately labeled
neurons were distributed in the anterior, ventromedial, laterodorsal, paraventricular
and central medial nuclei. Based on these distributions, we suggest that EP3 not
only mediates prostaglandin E2 signals evoked by blood-borne cytokines in the
areas poor in the blood-brain barrier, but also responds to those formed intrinsically
within the brain to modulate various neuronal activities. Possible EP3 actions
are discussed in relation to the reported neuronal activities of prostaglandin
E2 in the brain.
acknowledgement: 'This work was supported in part by Grants-in-aid for Scientific
Research 05404020, 04255103. 05771975, 05671816 and 05454568 from the Ministry of
Education, Science and Culture of Japan and by grants from the Mitsubishi Foundation
and the Takeda Science Foundation. We are grateful to Mr Akira Uesugi for photographic
help. We also thank Drs Chihiro Akazawa, Hitoshi Ohishi and Masabumi Minami for
helpful discussions. '
article_processing_charge: No
article_type: original
author:
- first_name: Yukihiko
full_name: Sugimoto, Yukihiko
last_name: Sugimoto
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Tsunehisa
full_name: Namba, Tsunehisa
last_name: Namba
- first_name: Manabu
full_name: Negishi, Manabu
last_name: Negishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
- first_name: Shuh
full_name: Narumiya, Shuh
last_name: Narumiya
- first_name: Atsushi
full_name: Ichikawa, Atsushi
last_name: Ichikawa
citation:
ama: Sugimoto Y, Shigemoto R, Namba T, et al. Distribution of the messenger rna
for the prostaglandin e receptor subtype ep3 in the mouse nervous system. Neuroscience.
1994;62(3):919-928. doi:10.1016/0306-4522(94)90483-9
apa: Sugimoto, Y., Shigemoto, R., Namba, T., Negishi, M., Mizuno, N., Narumiya,
S., & Ichikawa, A. (1994). Distribution of the messenger rna for the prostaglandin
e receptor subtype ep3 in the mouse nervous system. Neuroscience. Elsevier.
https://doi.org/10.1016/0306-4522(94)90483-9
chicago: Sugimoto, Yukihiko, Ryuichi Shigemoto, Tsunehisa Namba, Manabu Negishi,
Noboru Mizuno, Shuh Narumiya, and Atsushi Ichikawa. “Distribution of the Messenger
Rna for the Prostaglandin e Receptor Subtype Ep3 in the Mouse Nervous System.”
Neuroscience. Elsevier, 1994. https://doi.org/10.1016/0306-4522(94)90483-9.
ieee: Y. Sugimoto et al., “Distribution of the messenger rna for the prostaglandin
e receptor subtype ep3 in the mouse nervous system,” Neuroscience, vol.
62, no. 3. Elsevier, pp. 919–928, 1994.
ista: Sugimoto Y, Shigemoto R, Namba T, Negishi M, Mizuno N, Narumiya S, Ichikawa
A. 1994. Distribution of the messenger rna for the prostaglandin e receptor subtype
ep3 in the mouse nervous system. Neuroscience. 62(3), 919–928.
mla: Sugimoto, Yukihiko, et al. “Distribution of the Messenger Rna for the Prostaglandin
e Receptor Subtype Ep3 in the Mouse Nervous System.” Neuroscience, vol.
62, no. 3, Elsevier, 1994, pp. 919–28, doi:10.1016/0306-4522(94)90483-9.
short: Y. Sugimoto, R. Shigemoto, T. Namba, M. Negishi, N. Mizuno, S. Narumiya,
A. Ichikawa, Neuroscience 62 (1994) 919–928.
date_created: 2018-12-11T11:57:58Z
date_published: 1994-10-01T00:00:00Z
date_updated: 2022-06-09T11:56:23Z
day: '01'
doi: 10.1016/0306-4522(94)90483-9
extern: '1'
external_id:
pmid:
- '7870313'
intvolume: ' 62'
issue: '3'
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/0306452294904839?via%3Dihub
month: '10'
oa_version: None
page: 919 - 928
pmid: 1
publication: Neuroscience
publication_identifier:
issn:
- 0306-4522
publication_status: published
publisher: Elsevier
publist_id: '4411'
quality_controlled: '1'
status: public
title: Distribution of the messenger rna for the prostaglandin e receptor subtype
ep3 in the mouse nervous system
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 62
year: '1994'
...
---
_id: '2545'
abstract:
- lang: eng
text: 'Glutamate receptors play an important role in many integrative brain functions
and in neuronal development. We report the molecular diversity of NMDA receptors
and metabotropic glutamate receptors on the basis of our studies of molecular
cloning and characterization of the diverse members of these receptors. The NMDA
receptors consist of two distinct types of subunits. NMDAR1 possesses all properties
characteristic of the NMDA receptor-channel complex, whereas the four NMDAR2 subunits,
termed NMDAR2A-2D, show no channel activity but potentiate the NMDAR1 activity
and confer functional variability by different heteromeric formations. The NMDA
receptor subunits are considerably divergent from the other ligand-gated ion channels,
and the structural architecture of these subunits remains elusive. The mGluRs
form a family of at least seven different subtypes termed mGluR1-mGluR7. These
receptor subtypes have, seven transmembrane segments and possess a large extracellular
domain at their N-terminal regions. The seven mGluR subtypes are classified into
three subgroups according to their sequence similarities, signal transduction
mechanisms and agonist selectivities: mGluR1/mGluR5, mGluR2/mGluR3 and mGluR4/mGluR6/mGluR7.
On the basis of our knowledge of the molecular diversity of the NMDA receptors
and mGluRs, we have studied the physiological roles of individual receptor subunits
or subtypes. We have shown that K(+)-induced depolarization or NMDA treatment
in primary cultures of neonatal cerebellar granule cells induces the functional
NMDA receptor and specifically up-regulates NMDAR2A mRNA among the multiple NMDA
receptor subunits through the increase in resting intracellular Ca2+ concentrations.
Our study demonstrates that the regulation of the specific NMDA receptor subunit
mRNA governs the NMDA receptor induction that is thought to play an important
role in granule cell survival and death. Analysis of an agonist selectivity and
an expression pattern of mGluR6 has indicated that mGluR6 is responsible for synaptic
neurotransmission from photoreceptor cells to ON-bipolar cells in the visual system.
We have also investigated the function of mGluR2 in granule cells of the accessory
olfactory bulb by combining immunoelectron-microscopic analysis with slice-patch
recordings on the basis of the identification of a new agonist selective for this
receptor subtype. Our results demonstrate that mGluR2 is present at the presynaptic
site of granule cells and modulates inhibitory GABA transmission from granule
cells to mitral cells. This finding indicates that the mGluR2 activation relieves
excited mitral cells from GABA inhibition but maintains the lateral inhibition
of unexcited mitral cells, thus resulting in enhancement of the signal-to-noise
ratio between the excited mitral cells and their neighboring unexcited mitral
cells.'
article_processing_charge: No
author:
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Masayuki
full_name: Masu, Masayuki
last_name: Masu
- first_name: Yasumasa
full_name: Bessho, Yasumasa
last_name: Bessho
- first_name: Yoshiaki
full_name: Nakajima, Yoshiaki
last_name: Nakajima
- first_name: Yasunori
full_name: Hayashi, Yasunori
last_name: Hayashi
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
citation:
ama: 'Nakanishi S, Masu M, Bessho Y, Nakajima Y, Hayashi Y, Shigemoto R. Molecular
diversity of glutamate receptors and their physiological functions. In: Experientia
Supplementum. Vol 71. Birkhäuser; 1994:71-80. doi:10.1007/978-3-0348-7330-7_8'
apa: Nakanishi, S., Masu, M., Bessho, Y., Nakajima, Y., Hayashi, Y., & Shigemoto,
R. (1994). Molecular diversity of glutamate receptors and their physiological
functions. In Experientia Supplementum (Vol. 71, pp. 71–80). Birkhäuser.
https://doi.org/10.1007/978-3-0348-7330-7_8
chicago: Nakanishi, Shigetada, Masayuki Masu, Yasumasa Bessho, Yoshiaki Nakajima,
Yasunori Hayashi, and Ryuichi Shigemoto. “Molecular Diversity of Glutamate Receptors
and Their Physiological Functions.” In Experientia Supplementum, 71:71–80.
Birkhäuser, 1994. https://doi.org/10.1007/978-3-0348-7330-7_8.
ieee: S. Nakanishi, M. Masu, Y. Bessho, Y. Nakajima, Y. Hayashi, and R. Shigemoto,
“Molecular diversity of glutamate receptors and their physiological functions,”
in Experientia Supplementum, vol. 71, Birkhäuser, 1994, pp. 71–80.
ista: 'Nakanishi S, Masu M, Bessho Y, Nakajima Y, Hayashi Y, Shigemoto R. 1994.Molecular
diversity of glutamate receptors and their physiological functions. In: Experientia
Supplementum. vol. 71, 71–80.'
mla: Nakanishi, Shigetada, et al. “Molecular Diversity of Glutamate Receptors and
Their Physiological Functions.” Experientia Supplementum, vol. 71, Birkhäuser,
1994, pp. 71–80, doi:10.1007/978-3-0348-7330-7_8.
short: S. Nakanishi, M. Masu, Y. Bessho, Y. Nakajima, Y. Hayashi, R. Shigemoto,
in:, Experientia Supplementum, Birkhäuser, 1994, pp. 71–80.
date_created: 2018-12-11T11:58:18Z
date_published: 1994-01-01T00:00:00Z
date_updated: 2022-06-09T10:08:24Z
day: '01'
doi: 10.1007/978-3-0348-7330-7_8
extern: '1'
external_id:
pmid:
- '8032174'
intvolume: ' 71'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/chapter/10.1007/978-3-0348-7330-7_8
month: '01'
oa_version: None
page: 71 - 80
pmid: 1
publication: Experientia Supplementum
publication_identifier:
isbn:
- '9783034873321'
publication_status: published
publisher: Birkhäuser
publist_id: '4352'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Molecular diversity of glutamate receptors and their physiological functions
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 71
year: '1994'
...
---
_id: '2548'
abstract:
- lang: eng
text: The induction mechanism of cerebellar long term depression (LTD) has been
analysed in a cerebellar culture. Using nitr-5, a photolabile Ca chelator, we
demonstrated that an increase in postsynaptic Ca together with glutamate application
is sufficient to induce the LTD of glutamate responsiveness in Purkinje cells.
It has also been shown that one subtype of genetically defined metabotropic glutamate
receptor, mGluR1, is involved in the LTD induction. We raised antibodies which
specifically recognized mGluR1 and inactivated its function. The antibodies suppressed
the LTD induction in the cultured Purkinje cells.
alternative_title:
- Biomedical Research
author:
- first_name: Tomoo
full_name: Hirano, Tomoo
last_name: Hirano
- first_name: Keizo
full_name: Kasono, Keizo
last_name: Kasono
- first_name: Ryuichi
full_name: Ryuichi Shigemoto
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
citation:
ama: 'Hirano T, Kasono K, Shigemoto R, Nakanishi S. Induction mechanism of long
term depression in cultured Purkinje neurons. In: Vol 15. Biomedical Research
Foundation; 1994:79-81.'
apa: Hirano, T., Kasono, K., Shigemoto, R., & Nakanishi, S. (1994). Induction
mechanism of long term depression in cultured Purkinje neurons (Vol. 15, pp. 79–81).
Presented at the Unknown (0388-6107), Biomedical Research Foundation.
chicago: Hirano, Tomoo, Keizo Kasono, Ryuichi Shigemoto, and Shigetada Nakanishi.
“Induction Mechanism of Long Term Depression in Cultured Purkinje Neurons,” 15:79–81.
Biomedical Research Foundation, 1994.
ieee: T. Hirano, K. Kasono, R. Shigemoto, and S. Nakanishi, “Induction mechanism
of long term depression in cultured Purkinje neurons,” presented at the Unknown
(0388-6107), 1994, vol. 15, no. SUPPL. 1, pp. 79–81.
ista: Hirano T, Kasono K, Shigemoto R, Nakanishi S. 1994. Induction mechanism of
long term depression in cultured Purkinje neurons. Unknown (0388-6107), Biomedical
Research, vol. 15, 79–81.
mla: Hirano, Tomoo, et al. Induction Mechanism of Long Term Depression in Cultured
Purkinje Neurons. Vol. 15, no. SUPPL. 1, Biomedical Research Foundation, 1994,
pp. 79–81.
short: T. Hirano, K. Kasono, R. Shigemoto, S. Nakanishi, in:, Biomedical Research
Foundation, 1994, pp. 79–81.
conference:
name: Unknown (0388-6107)
date_created: 2018-12-11T11:58:19Z
date_published: 1994-01-01T00:00:00Z
date_updated: 2021-01-12T06:58:10Z
day: '01'
extern: 1
intvolume: ' 15'
issue: SUPPL. 1
month: '01'
page: 79 - 81
publication_status: published
publisher: Biomedical Research Foundation
publist_id: '4350'
quality_controlled: 0
status: public
title: Induction mechanism of long term depression in cultured Purkinje neurons
type: conference
volume: 15
year: '1994'
...
---
_id: '2549'
abstract:
- lang: eng
text: In an attempt to reveal the function sites of substance P (SP) in the central
nervous system (CNS), the distribution of SP receptor (SPR) was immunocytochemically
investigated in adult rat and compared with that of SP- positive fibers. SPR-like
immunoreactivity (LI) was mostly localized to neuronal cell bodies and dendrites.
Neurons with intense SPR-LI were distributed densely in the cortical amygdaloid
nucleus, hilus of the dentate gyrus, locus ceruleus, rostral half of the ambiguus
nucleus, and intermediolateral nucleus of the thoracic cord; moderately in the
caudatoputamen, nucleus accumbens, olfactory tubercle, median, pontine, and magnus
raphe nuclei, laminae I and III of the caudal subnucleus of the spinal trigeminal
nucleus, and lamina I of the spinal cord; and sparsely in the cerebral cortex,
basal nucleus of Meynert, claustrum, gigantocellular reticular nucleus, and lobules
IX and X of the cerebellar vermis. Neurons with weak to moderate SPR-LI were distributed
more widely throughout the CNS. The regional patterns of distribution of SPR-LI
were not necessarily the same as those of SP-positive fibers. The entopeduncular
nucleus, substantia nigra, and lateral part of the interpeduncular nucleus showed
intense SP-LI but displayed almost no SPR-LI. Conversely, the hilus of the dentate
gyrus, anterodorsal thalamic nucleus, central nucleus of the inferior colliculus,
and dorsal tegmental nucleus showed intense to moderate SPR-LI but contained few
axons with SP-LI. These findings confirmed the presence of the 'mismatch' problem
between SP and SPR localizations. However, the distribution of SPR- LI was quite
consistent with that of the SP-binding activity, which has been studied via autoradiography.
This indicates that the sites of SPR-LI revealed in the present study represent
most, if not all, sites of SP-binding activity.
acknowledgement: 'We are grateful for photographic help of Mr. A. Uesugi and the support
of Drs. M. Arakawa, S. Fukuchi, T., Fukuda, R. Hayashi, S. Hayashi, S. Imai, M.
Katsurada, Y. Kitani, K. Kumagai, H. Kuroda, T. Kuroda, H. Matsubara, J. Matsuoka,
H. Matsushima, M. Nishio, G. Niwa, H. Oda, M. Ohbayashi, S. Ohbayashi, H. Ohtsuka,
S. Tamaki, E. Watanabe, and Y. Yoshino. This work was supported in part by Grants-in-Aid
for Scientific Research on Priority Areas 05248207 and 05267104 and Scientific Research
(B) 05454658 and (C) 05680658 from the Ministry of Education, Science and Culture
of Japan. '
article_processing_charge: No
article_type: original
author:
- first_name: Yoshifumi
full_name: Nakaya, Yoshifumi
last_name: Nakaya
- first_name: Takeshi
full_name: Kaneko, Takeshi
last_name: Kaneko
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Nakaya Y, Kaneko T, Shigemoto R, Nakanishi S, Mizuno N. Immunohistochemical
localization of substance P receptor in the central nervous system of the adult
rat. Journal of Comparative Neurology. 1994;347(2):249-274. doi:10.1002/cne.903470208
apa: Nakaya, Y., Kaneko, T., Shigemoto, R., Nakanishi, S., & Mizuno, N. (1994).
Immunohistochemical localization of substance P receptor in the central nervous
system of the adult rat. Journal of Comparative Neurology. Wiley-Blackwell.
https://doi.org/10.1002/cne.903470208
chicago: Nakaya, Yoshifumi, Takeshi Kaneko, Ryuichi Shigemoto, Shigetada Nakanishi,
and Noboru Mizuno. “Immunohistochemical Localization of Substance P Receptor in
the Central Nervous System of the Adult Rat.” Journal of Comparative Neurology.
Wiley-Blackwell, 1994. https://doi.org/10.1002/cne.903470208.
ieee: Y. Nakaya, T. Kaneko, R. Shigemoto, S. Nakanishi, and N. Mizuno, “Immunohistochemical
localization of substance P receptor in the central nervous system of the adult
rat,” Journal of Comparative Neurology, vol. 347, no. 2. Wiley-Blackwell,
pp. 249–274, 1994.
ista: Nakaya Y, Kaneko T, Shigemoto R, Nakanishi S, Mizuno N. 1994. Immunohistochemical
localization of substance P receptor in the central nervous system of the adult
rat. Journal of Comparative Neurology. 347(2), 249–274.
mla: Nakaya, Yoshifumi, et al. “Immunohistochemical Localization of Substance P
Receptor in the Central Nervous System of the Adult Rat.” Journal of Comparative
Neurology, vol. 347, no. 2, Wiley-Blackwell, 1994, pp. 249–74, doi:10.1002/cne.903470208.
short: Y. Nakaya, T. Kaneko, R. Shigemoto, S. Nakanishi, N. Mizuno, Journal of Comparative
Neurology 347 (1994) 249–274.
date_created: 2018-12-11T11:58:20Z
date_published: 1994-09-08T00:00:00Z
date_updated: 2022-06-09T09:25:30Z
day: '08'
doi: 10.1002/cne.903470208
extern: '1'
external_id:
pmid:
- '7814667'
intvolume: ' 347'
issue: '2'
language:
- iso: eng
main_file_link:
- url: https://onlinelibrary.wiley.com/doi/10.1002/cne.903470208
month: '09'
oa_version: None
page: 249 - 274
pmid: 1
publication: Journal of Comparative Neurology
publication_identifier:
issn:
- 0021-9967
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4349'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Immunohistochemical localization of substance P receptor in the central nervous
system of the adult rat
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 347
year: '1994'
...
---
_id: '2550'
abstract:
- lang: eng
text: A cDNA clone for a new rat metabotropic glutamate receptor termed mGluR7 was
isolated through polymerase chain reaction-mediated DNA amplification by using
primer sequences conserved among the metabotropic receptor (mGluR) family and
by the subsequent screening of a rat forebrain cDNA library. The cloned mGluR7
subtype consists of 915 amino acid residues and exhibits a structural architecture
common to the mGluR family with a large extracellular domain preceding the seven
putative membrane-spanning domains. mGluR7 shows the highest sequence similarity
to mGluR4 and mGluR6 among the members of the mGluR family. Similar to mGluR4
and mGluR6, mGluR7 inhibits forskolin- stimulated cyclic AMP accumulation in response
to agonist interaction and potently reacts with L-2-amino-4-phosphonobutyrate
and L-serine-O-phosphate in Chinese hamster ovary cells transfected with the cloned
cDNA. RNA blot and in situ hybridization analyses of mGluR7 mRNA indicated that
it is widely expressed in many neuronal cells of the central nervous system and
is thus different from the more limitedly expressed mGluR4 or mGluR6 mRNA. mGluR7
together with mGluR4 thus corresponds to the putative L-2-amino-4- phosphonobutyrate
receptor which plays an important role in modulation of glutamate transmission
in the central nervous system.
acknowledgement: We are grateful to Akira Uesugi for photographic assistance.
article_processing_charge: No
author:
- first_name: Naoyuki
full_name: Okamoto, Naoyuki
last_name: Okamoto
- first_name: Seiji
full_name: Hori, Seiji
last_name: Hori
- first_name: Chihiro
full_name: Akazawa, Chihiro
last_name: Akazawa
- first_name: Yasunori
full_name: Hayashi, Yasunori
last_name: Hayashi
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
citation:
ama: Okamoto N, Hori S, Akazawa C, et al. Molecular characterization of a new metabotropic
glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction.
Journal of Biological Chemistry. 1994;269(2):1231-1236. doi:10.1016/S0021-9258(17)42247-2
apa: Okamoto, N., Hori, S., Akazawa, C., Hayashi, Y., Shigemoto, R., Mizuno, N.,
& Nakanishi, S. (1994). Molecular characterization of a new metabotropic glutamate
receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction. Journal
of Biological Chemistry. American Society for Biochemistry and Molecular Biology.
https://doi.org/10.1016/S0021-9258(17)42247-2
chicago: Okamoto, Naoyuki, Seiji Hori, Chihiro Akazawa, Yasunori Hayashi, Ryuichi
Shigemoto, Noboru Mizuno, and Shigetada Nakanishi. “Molecular Characterization
of a New Metabotropic Glutamate Receptor MGluR7 Coupled to Inhibitory Cyclic AMP
Signal Transduction.” Journal of Biological Chemistry. American Society
for Biochemistry and Molecular Biology, 1994. https://doi.org/10.1016/S0021-9258(17)42247-2.
ieee: N. Okamoto et al., “Molecular characterization of a new metabotropic
glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction,”
Journal of Biological Chemistry, vol. 269, no. 2. American Society for
Biochemistry and Molecular Biology, pp. 1231–1236, 1994.
ista: Okamoto N, Hori S, Akazawa C, Hayashi Y, Shigemoto R, Mizuno N, Nakanishi
S. 1994. Molecular characterization of a new metabotropic glutamate receptor mGluR7
coupled to inhibitory cyclic AMP signal transduction. Journal of Biological Chemistry.
269(2), 1231–1236.
mla: Okamoto, Naoyuki, et al. “Molecular Characterization of a New Metabotropic
Glutamate Receptor MGluR7 Coupled to Inhibitory Cyclic AMP Signal Transduction.”
Journal of Biological Chemistry, vol. 269, no. 2, American Society for
Biochemistry and Molecular Biology, 1994, pp. 1231–36, doi:10.1016/S0021-9258(17)42247-2.
short: N. Okamoto, S. Hori, C. Akazawa, Y. Hayashi, R. Shigemoto, N. Mizuno, S.
Nakanishi, Journal of Biological Chemistry 269 (1994) 1231–1236.
date_created: 2018-12-11T11:58:20Z
date_published: 1994-01-14T00:00:00Z
date_updated: 2022-06-08T15:11:44Z
day: '14'
doi: 10.1016/S0021-9258(17)42247-2
extern: '1'
external_id:
pmid:
- '8288585'
intvolume: ' 269'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S0021925817422472?via%3Dihub
month: '01'
oa: 1
oa_version: None
page: 1231 - 1236
pmid: 1
publication: Journal of Biological Chemistry
publication_status: published
publisher: American Society for Biochemistry and Molecular Biology
publist_id: '4348'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Molecular characterization of a new metabotropic glutamate receptor mGluR7
coupled to inhibitory cyclic AMP signal transduction
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 269
year: '1994'
...
---
_id: '2551'
abstract:
- lang: eng
text: Expression patterns of mRNAs of l-AP4-sensitive metabotropic glutamate receptors
(mGluR4, mGluR6, mGluR7) in the rat retina were examined by northern blot analysis
and in situ hybridization histochemistry. Expression patterns of mGluR4 and mGluR7
mRNAs were quite different from that of mGluR6 mRNA which was expressed at the
outer part of the inner nuclear layer. The mGluR4 mRNA was expressed on the cell
bodies of the ganglion cells, but not in the inner or outer nuclear layer. The
expression of mGluR7 mRNA was observed throughout the entire region of the inner
nuclear layer and on the cell bodies of the ganglion cells.
acknowledgement: The photographic help of Mr. Akira Uesugi is gratefully acknowledged.
This work has been supported by research grants from the Ministry of Education,
Science and Culture of Japan.
article_processing_charge: No
article_type: original
author:
- first_name: Chihiro
full_name: Akazawa, Chihiro
last_name: Akazawa
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Yoshiaki
full_name: Nakajima, Yoshiaki
last_name: Nakajima
- first_name: Naoyuki
full_name: Okamoto, Naoyuki
last_name: Okamoto
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Akazawa C, Ohishi H, Nakajima Y, et al. Expression of mRNAs of l-AP4-sensitive
metabotropic glutamate receptors (mGluR4, mGluR6, mGluR7) in the rat retina. Neuroscience
Letters. 1994;171(1-2):52-54. doi:10.1016/0304-3940(94)90602-5
apa: Akazawa, C., Ohishi, H., Nakajima, Y., Okamoto, N., Shigemoto, R., Nakanishi,
S., & Mizuno, N. (1994). Expression of mRNAs of l-AP4-sensitive metabotropic
glutamate receptors (mGluR4, mGluR6, mGluR7) in the rat retina. Neuroscience
Letters. Elsevier. https://doi.org/10.1016/0304-3940(94)90602-5
chicago: Akazawa, Chihiro, Hitoshi Ohishi, Yoshiaki Nakajima, Naoyuki Okamoto, Ryuichi
Shigemoto, Shigetada Nakanishi, and Noboru Mizuno. “Expression of MRNAs of L-AP4-Sensitive
Metabotropic Glutamate Receptors (MGluR4, MGluR6, MGluR7) in the Rat Retina.”
Neuroscience Letters. Elsevier, 1994. https://doi.org/10.1016/0304-3940(94)90602-5.
ieee: C. Akazawa et al., “Expression of mRNAs of l-AP4-sensitive metabotropic
glutamate receptors (mGluR4, mGluR6, mGluR7) in the rat retina,” Neuroscience
Letters, vol. 171, no. 1–2. Elsevier, pp. 52–54, 1994.
ista: Akazawa C, Ohishi H, Nakajima Y, Okamoto N, Shigemoto R, Nakanishi S, Mizuno
N. 1994. Expression of mRNAs of l-AP4-sensitive metabotropic glutamate receptors
(mGluR4, mGluR6, mGluR7) in the rat retina. Neuroscience Letters. 171(1–2), 52–54.
mla: Akazawa, Chihiro, et al. “Expression of MRNAs of L-AP4-Sensitive Metabotropic
Glutamate Receptors (MGluR4, MGluR6, MGluR7) in the Rat Retina.” Neuroscience
Letters, vol. 171, no. 1–2, Elsevier, 1994, pp. 52–54, doi:10.1016/0304-3940(94)90602-5.
short: C. Akazawa, H. Ohishi, Y. Nakajima, N. Okamoto, R. Shigemoto, S. Nakanishi,
N. Mizuno, Neuroscience Letters 171 (1994) 52–54.
date_created: 2018-12-11T11:58:21Z
date_published: 1994-04-25T00:00:00Z
date_updated: 2022-06-08T14:02:11Z
day: '25'
doi: 10.1016/0304-3940(94)90602-5
extern: '1'
external_id:
pmid:
- '8084499'
intvolume: ' 171'
issue: 1-2
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/0304394094906025?via%3Dihub
month: '04'
oa_version: None
page: 52 - 54
pmid: 1
publication: Neuroscience Letters
publication_identifier:
issn:
- 0304-3940
publication_status: published
publisher: Elsevier
publist_id: '4346'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Expression of mRNAs of l-AP4-sensitive metabotropic glutamate receptors (mGluR4,
mGluR6, mGluR7) in the rat retina
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 171
year: '1994'
...
---
_id: '2552'
abstract:
- lang: eng
text: The superficial layers of the superior colliculus (SC) have been known to
contain many axons showing substance P-like immunoreactivity (SP-LI). We, therefore,
immunohistochemically examined the distribution of SP receptor (SPR) in the superficial
layers of the SC in the rat by using a specific antibody against SPR. The majority
of SC neurons with SPR-LI were distributed in the zonal and the superficial gray
layers, the rest of them were in the optic layer. Electron microscopy revealed
that SPR-immunoreaction products in SC neurons were distributed not only in postsynaptic
sites, but also in non-synaptic regions of perikaryal and dendritic profiles.
acknowledgement: The authors are grateful for photographic help of Mr. Akira Uesugi.
article_processing_charge: No
article_type: original
author:
- first_name: Reiko
full_name: Ogawa Meguro, Reiko
last_name: Ogawa Meguro
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Kazuo
full_name: Itoh, Kazuo
last_name: Itoh
- first_name: Akira
full_name: Konishi, Akira
last_name: Konishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Ogawa Meguro R, Shigemoto R, Itoh K, Konishi A, Mizuno N. Immunohistochemical
localization of substance P receptor in the superior colliculus. A light and electron
microscope study in the rat. Neuroscience Letters. 1994;166(2):135-138.
doi:10.1016/0304-3940(94)90469-3
apa: Ogawa Meguro, R., Shigemoto, R., Itoh, K., Konishi, A., & Mizuno, N. (1994).
Immunohistochemical localization of substance P receptor in the superior colliculus.
A light and electron microscope study in the rat. Neuroscience Letters.
Elsevier. https://doi.org/10.1016/0304-3940(94)90469-3
chicago: Ogawa Meguro, Reiko, Ryuichi Shigemoto, Kazuo Itoh, Akira Konishi, and
Noboru Mizuno. “Immunohistochemical Localization of Substance P Receptor in the
Superior Colliculus. A Light and Electron Microscope Study in the Rat.” Neuroscience
Letters. Elsevier, 1994. https://doi.org/10.1016/0304-3940(94)90469-3.
ieee: R. Ogawa Meguro, R. Shigemoto, K. Itoh, A. Konishi, and N. Mizuno, “Immunohistochemical
localization of substance P receptor in the superior colliculus. A light and electron
microscope study in the rat,” Neuroscience Letters, vol. 166, no. 2. Elsevier,
pp. 135–138, 1994.
ista: Ogawa Meguro R, Shigemoto R, Itoh K, Konishi A, Mizuno N. 1994. Immunohistochemical
localization of substance P receptor in the superior colliculus. A light and electron
microscope study in the rat. Neuroscience Letters. 166(2), 135–138.
mla: Ogawa Meguro, Reiko, et al. “Immunohistochemical Localization of Substance
P Receptor in the Superior Colliculus. A Light and Electron Microscope Study in
the Rat.” Neuroscience Letters, vol. 166, no. 2, Elsevier, 1994, pp. 135–38,
doi:10.1016/0304-3940(94)90469-3.
short: R. Ogawa Meguro, R. Shigemoto, K. Itoh, A. Konishi, N. Mizuno, Neuroscience
Letters 166 (1994) 135–138.
date_created: 2018-12-11T11:58:21Z
date_published: 1994-01-31T00:00:00Z
date_updated: 2022-06-08T14:37:30Z
day: '31'
doi: 10.1016/0304-3940(94)90469-3
extern: '1'
external_id:
pmid:
- '8177489'
intvolume: ' 166'
issue: '2'
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/0304394094904693?via%3Dihub
month: '01'
oa_version: None
page: 135 - 138
pmid: 1
publication: Neuroscience Letters
publication_identifier:
issn:
- 0304-3940
publication_status: published
publisher: Elsevier
publist_id: '4347'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Immunohistochemical localization of substance P receptor in the superior colliculus.
A light and electron microscope study in the rat
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 166
year: '1994'
...
---
_id: '2553'
abstract:
- lang: eng
text: Distribution of the mRNAs for three subtypes of prostaglandin E (PGE) receptors
in the mouse kidney was investigated by in situ hybridization. The mRNA for EP1
subtype, which is coupled to Ca2+ mobilization, was specifically localized to
the collecting ducts from the cortex to the papilla. The mRNA for EP2 subtype,
which is linked to stimulation of adenylate cyclase, was localized to the glomeruli.
The mRNA for EP3 subtype, which is coupled to inhibition of adenylate cyclase,
was located densely in the tubules in the outer medulla and in the distal tubules
in the cortex. These results exhibit distinct cellular localization of three subtypes
of PGE receptor in the kidney and suggest that PGE2 exerts multiple functions
via these subtypes expressed in different segments of the nephron.
acknowledgement: We thank Drs. Noboru Mizuno, Tsuyoshi Watanabe, Akihide Nakao, Chihiro
Akazawa, and Akira Uesugi for invaluable discussions and photographic support. This
work was supported in part by Scientific Research Grants-inAid 05404020, 04255103,
05771975, 05671816, and 05454568 from the Ministry of Education, Science and Culture
of Japan and by grants from the Mitsubishi Foundation and the Takeda Science Foundation.
article_processing_charge: No
article_type: original
author:
- first_name: Yukihiko
full_name: Sugimoto, Yukihiko
last_name: Sugimoto
- first_name: Tsunehisa
full_name: Namba, Tsunehisa
last_name: Namba
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Manabu
full_name: Negishi, Manabu
last_name: Negishi
- first_name: Atsushi
full_name: Ichikawa, Atsushi
last_name: Ichikawa
- first_name: Shuh
full_name: Narumiya, Shuh
last_name: Narumiya
citation:
ama: Sugimoto Y, Namba T, Shigemoto R, Negishi M, Ichikawa A, Narumiya S. Distinct
cellular localization of mRNAs for three subtypes of prostaglandin E receptor
in kidney. American Journal of Physiology. 1994;266(5):F823-F828. doi:10.1152/ajprenal.1994.266.5.F823
apa: Sugimoto, Y., Namba, T., Shigemoto, R., Negishi, M., Ichikawa, A., & Narumiya,
S. (1994). Distinct cellular localization of mRNAs for three subtypes of prostaglandin
E receptor in kidney. American Journal of Physiology. American Physiological
Society. https://doi.org/10.1152/ajprenal.1994.266.5.F823
chicago: Sugimoto, Yukihiko, Tsunehisa Namba, Ryuichi Shigemoto, Manabu Negishi,
Atsushi Ichikawa, and Shuh Narumiya. “Distinct Cellular Localization of MRNAs
for Three Subtypes of Prostaglandin E Receptor in Kidney.” American Journal
of Physiology. American Physiological Society, 1994. https://doi.org/10.1152/ajprenal.1994.266.5.F823.
ieee: Y. Sugimoto, T. Namba, R. Shigemoto, M. Negishi, A. Ichikawa, and S. Narumiya,
“Distinct cellular localization of mRNAs for three subtypes of prostaglandin E
receptor in kidney,” American Journal of Physiology, vol. 266, no. 5. American
Physiological Society, pp. F823–F828, 1994.
ista: Sugimoto Y, Namba T, Shigemoto R, Negishi M, Ichikawa A, Narumiya S. 1994.
Distinct cellular localization of mRNAs for three subtypes of prostaglandin E
receptor in kidney. American Journal of Physiology. 266(5), F823–F828.
mla: Sugimoto, Yukihiko, et al. “Distinct Cellular Localization of MRNAs for Three
Subtypes of Prostaglandin E Receptor in Kidney.” American Journal of Physiology,
vol. 266, no. 5, American Physiological Society, 1994, pp. F823–28, doi:10.1152/ajprenal.1994.266.5.F823.
short: Y. Sugimoto, T. Namba, R. Shigemoto, M. Negishi, A. Ichikawa, S. Narumiya,
American Journal of Physiology 266 (1994) F823–F828.
date_created: 2018-12-11T11:58:21Z
date_published: 1994-05-01T00:00:00Z
date_updated: 2022-06-07T15:03:51Z
day: '01'
doi: 10.1152/ajprenal.1994.266.5.F823
extern: '1'
external_id:
pmid:
- '8203567'
intvolume: ' 266'
issue: '5'
language:
- iso: eng
main_file_link:
- url: https://journals.physiology.org/doi/abs/10.1152/ajprenal.1994.266.5.F823
month: '05'
oa_version: None
page: F823 - F828
pmid: 1
publication: American Journal of Physiology
publication_identifier:
issn:
- 0363-6127
publication_status: published
publisher: American Physiological Society
publist_id: '4345'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Distinct cellular localization of mRNAs for three subtypes of prostaglandin
E receptor in kidney
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 266
year: '1994'
...
---
_id: '2554'
abstract:
- lang: eng
text: 'The retinal bipolar cell receiving glutamate transmission from photoreceptors
mediates a key process in segregating visual signals into ON center and OFF center
pathways. This transmission involves a G protein- coupled metabotropic glutamate
receptor (mGluR). Immunocytochemical and immunoelectron microscopic studies indicate
the restricted localization of a specific mGluR subtype, mGluR6, at the postsynaptic
site of the rat rod bipolar cell. This specialization is developmentally regulated:
mGluR6 is initially distributed in both the soma and dendrites and is finally
concentrated on the postsynaptic site. The mGluR6 localization is reversed when
photoreceptors degenerate in the mutant rat with retinal dystrophy. Evidence is
thus presented indicating specialized, developmentally regulated receptor distribution
in the central nervous system and the crucial role of mGluR6 in photoreceptor-bipolar
cell synaptic transmission.'
acknowledgement: "We thank M. Tachibana for technical advice concerning dissociated
bipolar cell preparation, Y. Honda for advice \r\nconcerning RCS rat experiments,
and A. Uesugi for photographic assistance. This work is partly supported by research
grants from the Ministry of Education, Science, and Culture of Japan and from the
Ministry of Health and Welfare of\r\nJapan. "
article_processing_charge: No
article_type: original
author:
- first_name: Akinori
full_name: Nomura, Akinori
last_name: Nomura
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Yasuhisa
full_name: Nakamura, Yasuhisa
last_name: Nakamura
- first_name: Naoyuki
full_name: Okamoto, Naoyuki
last_name: Okamoto
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
citation:
ama: Nomura A, Shigemoto R, Nakamura Y, Okamoto N, Mizuno N, Nakanishi S. Developmentally
regulated postsynaptic localization of a metabotropic glutamate receptor in rat
rod bipolar cells. Cell. 1994;77(3):361-369. doi:10.1016/0092-8674(94)90151-1
apa: Nomura, A., Shigemoto, R., Nakamura, Y., Okamoto, N., Mizuno, N., & Nakanishi,
S. (1994). Developmentally regulated postsynaptic localization of a metabotropic
glutamate receptor in rat rod bipolar cells. Cell. Cell Press. https://doi.org/10.1016/0092-8674(94)90151-1
chicago: Nomura, Akinori, Ryuichi Shigemoto, Yasuhisa Nakamura, Naoyuki Okamoto,
Noboru Mizuno, and Shigetada Nakanishi. “Developmentally Regulated Postsynaptic
Localization of a Metabotropic Glutamate Receptor in Rat Rod Bipolar Cells.” Cell.
Cell Press, 1994. https://doi.org/10.1016/0092-8674(94)90151-1.
ieee: A. Nomura, R. Shigemoto, Y. Nakamura, N. Okamoto, N. Mizuno, and S. Nakanishi,
“Developmentally regulated postsynaptic localization of a metabotropic glutamate
receptor in rat rod bipolar cells,” Cell, vol. 77, no. 3. Cell Press, pp.
361–369, 1994.
ista: Nomura A, Shigemoto R, Nakamura Y, Okamoto N, Mizuno N, Nakanishi S. 1994.
Developmentally regulated postsynaptic localization of a metabotropic glutamate
receptor in rat rod bipolar cells. Cell. 77(3), 361–369.
mla: Nomura, Akinori, et al. “Developmentally Regulated Postsynaptic Localization
of a Metabotropic Glutamate Receptor in Rat Rod Bipolar Cells.” Cell, vol.
77, no. 3, Cell Press, 1994, pp. 361–69, doi:10.1016/0092-8674(94)90151-1.
short: A. Nomura, R. Shigemoto, Y. Nakamura, N. Okamoto, N. Mizuno, S. Nakanishi,
Cell 77 (1994) 361–369.
date_created: 2018-12-11T11:58:21Z
date_published: 1994-05-06T00:00:00Z
date_updated: 2022-06-07T14:28:33Z
day: '06'
doi: 10.1016/0092-8674(94)90151-1
extern: '1'
external_id:
pmid:
- '8181056'
intvolume: ' 77'
issue: '3'
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/0092867494901511?via%3Dihub
month: '05'
oa_version: None
page: 361 - 369
pmid: 1
publication: Cell
publication_identifier:
issn:
- 0092-8674
publication_status: published
publisher: Cell Press
publist_id: '4344'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Developmentally regulated postsynaptic localization of a metabotropic glutamate
receptor in rat rod bipolar cells
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 77
year: '1994'
...
---
_id: '2555'
abstract:
- lang: eng
text: Antibodies were raised against two distinct extracellular sequences of the
rat mGluR1 metabotropic glutamate receptor expressed as bacterial fusion proteins.
Both antibodies specifically reacted with mGluR1 in the rat cerebellum and inhibited
the mGluR1 activity as assessed by the analysis of glutamate-stimulated inositol
phosphate formation in CHO cells expressing mGluR1. Using these antibodies, we
examined the role of mGluR1 in the induction of long-term depression in cultured
Purkinje cells. In voltage- clamped Purkinje cells, current induced by iontophoretically
applied glutamate was persistently depressed by depolarization of the Purkinje
cells in conjunction with the glutamate application. The mGluR1 antibodies completely
blocked the depression of glutamate-induced current. The results indicate that
activation of mGluR1 is necessary for the induction of cerebellar long-term depression
and that these mGluR1 antibodies can be used as selective antagonists.
acknowledgement: 'Correspondence should be addressed to R. S. The photographic help
of Mr. Akira Uesugi is gratefully acknowledged. This work has been supported by
research grants from Senri Life Science Foundation, the Brain Science Foundation,
the Narishige Foundation, and the Ministry of Education, Science, and Culture of
Japan. The costs of publication of this article were defrayed in part by the payment
of page charges. This article must therefore be hereby marked "advertisement” in
accordance with 18 USC Section 1734 solely to indicate this fact. '
article_processing_charge: No
article_type: original
author:
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Takaaki
full_name: Abe, Takaaki
last_name: Abe
- first_name: Sakashi
full_name: Nomura, Sakashi
last_name: Nomura
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Tomoo
full_name: Hirano, Tomoo
last_name: Hirano
citation:
ama: Shigemoto R, Abe T, Nomura S, Nakanishi S, Hirano T. Antibodies inactivating
mGluR1 metabotropic glutamate receptor block long-term depression in cultured
Purkinje cells. Neuron. 1994;12(6):1245-1255. doi:10.1016/0896-6273(94)90441-3
apa: Shigemoto, R., Abe, T., Nomura, S., Nakanishi, S., & Hirano, T. (1994).
Antibodies inactivating mGluR1 metabotropic glutamate receptor block long-term
depression in cultured Purkinje cells. Neuron. Elsevier. https://doi.org/10.1016/0896-6273(94)90441-3
chicago: Shigemoto, Ryuichi, Takaaki Abe, Sakashi Nomura, Shigetada Nakanishi, and
Tomoo Hirano. “Antibodies Inactivating MGluR1 Metabotropic Glutamate Receptor
Block Long-Term Depression in Cultured Purkinje Cells.” Neuron. Elsevier,
1994. https://doi.org/10.1016/0896-6273(94)90441-3.
ieee: R. Shigemoto, T. Abe, S. Nomura, S. Nakanishi, and T. Hirano, “Antibodies
inactivating mGluR1 metabotropic glutamate receptor block long-term depression
in cultured Purkinje cells,” Neuron, vol. 12, no. 6. Elsevier, pp. 1245–1255,
1994.
ista: Shigemoto R, Abe T, Nomura S, Nakanishi S, Hirano T. 1994. Antibodies inactivating
mGluR1 metabotropic glutamate receptor block long-term depression in cultured
Purkinje cells. Neuron. 12(6), 1245–1255.
mla: Shigemoto, Ryuichi, et al. “Antibodies Inactivating MGluR1 Metabotropic Glutamate
Receptor Block Long-Term Depression in Cultured Purkinje Cells.” Neuron,
vol. 12, no. 6, Elsevier, 1994, pp. 1245–55, doi:10.1016/0896-6273(94)90441-3.
short: R. Shigemoto, T. Abe, S. Nomura, S. Nakanishi, T. Hirano, Neuron 12 (1994)
1245–1255.
date_created: 2018-12-11T11:58:22Z
date_published: 1994-06-01T00:00:00Z
date_updated: 2022-06-07T13:39:09Z
day: '01'
doi: 10.1016/0896-6273(94)90441-3
extern: '1'
external_id:
pmid:
- '7912091 '
intvolume: ' 12'
issue: '6'
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/0896627394904413?via%3Dihub
month: '06'
oa_version: None
page: 1245 - 1255
pmid: 1
publication: Neuron
publication_identifier:
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
publist_id: '4343'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Antibodies inactivating mGluR1 metabotropic glutamate receptor block long-term
depression in cultured Purkinje cells
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 12
year: '1994'
...
---
_id: '2557'
abstract:
- lang: eng
text: The distribution of the metabotropic glutamate receptors mGluR2 and mGluR3
was immunohistochemically examined in the rat cerebellar cortex at both light
and electron microscope levels. An antibody was raised against a fusion protein
containing a C-terminal portion of mGluR2. On immunoblot, the antibody reacted
with both mGluR2 and mGluR3 in rat brain. mGluR2/3 immunoreactivity was expressed
in cell bodies, dendrites, and axon terminals of Golgi cells, as well as in presumed
glial processes. Golgi axon terminals with mGluR2/3 immunoreactivity were often
encountered in the vicinity of glutamatergic mossy fiber terminals. The results
suggest that transmitter glutamate may exert control influences upon Golgi cells
not only through dendritic mGluR2/3, but also through axonal mGluR2/3.
acknowledgement: "We are grateful to Mr. Akira Uesugi for photographic help. This
work has been supported in part by research grants from the Ministry of Education,
Science and Culture of Japan. The costs of publication of this article were defrayed
in part\r\nby the payment of page charges. This article must therefore be hereby
marked “advertisement” in accordance with 18 USC Section 1734 solely to indicate
this fact. "
article_processing_charge: No
article_type: original
author:
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Reiko
full_name: Ogawa Meguro, Reiko
last_name: Ogawa Meguro
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Takeshi
full_name: Kaneko, Takeshi
last_name: Kaneko
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Ohishi H, Ogawa Meguro R, Shigemoto R, Kaneko T, Nakanishi S, Mizuno N. Immunohistochemical
localization of metabotropic glutamate receptors, mGluR2 and mGluR3, in rat cerebellar
cortex. Neuron. 1994;13(1):55-66. doi:10.1016/0896-6273(94)90459-6
apa: Ohishi, H., Ogawa Meguro, R., Shigemoto, R., Kaneko, T., Nakanishi, S., &
Mizuno, N. (1994). Immunohistochemical localization of metabotropic glutamate
receptors, mGluR2 and mGluR3, in rat cerebellar cortex. Neuron. Elsevier.
https://doi.org/10.1016/0896-6273(94)90459-6
chicago: Ohishi, Hitoshi, Reiko Ogawa Meguro, Ryuichi Shigemoto, Takeshi Kaneko,
Shigetada Nakanishi, and Noboru Mizuno. “Immunohistochemical Localization of Metabotropic
Glutamate Receptors, MGluR2 and MGluR3, in Rat Cerebellar Cortex.” Neuron.
Elsevier, 1994. https://doi.org/10.1016/0896-6273(94)90459-6.
ieee: H. Ohishi, R. Ogawa Meguro, R. Shigemoto, T. Kaneko, S. Nakanishi, and N.
Mizuno, “Immunohistochemical localization of metabotropic glutamate receptors,
mGluR2 and mGluR3, in rat cerebellar cortex,” Neuron, vol. 13, no. 1. Elsevier,
pp. 55–66, 1994.
ista: Ohishi H, Ogawa Meguro R, Shigemoto R, Kaneko T, Nakanishi S, Mizuno N. 1994.
Immunohistochemical localization of metabotropic glutamate receptors, mGluR2 and
mGluR3, in rat cerebellar cortex. Neuron. 13(1), 55–66.
mla: Ohishi, Hitoshi, et al. “Immunohistochemical Localization of Metabotropic Glutamate
Receptors, MGluR2 and MGluR3, in Rat Cerebellar Cortex.” Neuron, vol. 13,
no. 1, Elsevier, 1994, pp. 55–66, doi:10.1016/0896-6273(94)90459-6.
short: H. Ohishi, R. Ogawa Meguro, R. Shigemoto, T. Kaneko, S. Nakanishi, N. Mizuno,
Neuron 13 (1994) 55–66.
date_created: 2018-12-11T11:58:22Z
date_published: 1994-07-01T00:00:00Z
date_updated: 2022-06-07T13:21:58Z
day: '01'
doi: 10.1016/0896-6273(94)90459-6
extern: '1'
external_id:
pmid:
- '8043281'
intvolume: ' 13'
issue: '1'
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/0896627394904596?via%3Dihub
month: '07'
oa_version: None
page: 55 - 66
pmid: 1
publication: Neuron
publication_identifier:
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
publist_id: '4342'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Immunohistochemical localization of metabotropic glutamate receptors, mGluR2
and mGluR3, in rat cerebellar cortex
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 13
year: '1994'
...
---
_id: '2713'
acknowledgement: Work supported by the NSF grant PHY90-19433 A02 and by the Alfred
Sloan Foundation dissertation fellowship.
article_processing_charge: No
article_type: original
author:
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
citation:
ama: Erdös L. Estimates on stochastic oscillatory integrals and on the heat kernel
of the magnetic Schrödinger operator. Duke Mathematical Journal. 1994;76(2):541-566.
doi:10.1215/S0012-7094-94-07619-9
apa: Erdös, L. (1994). Estimates on stochastic oscillatory integrals and on the
heat kernel of the magnetic Schrödinger operator. Duke Mathematical Journal.
Duke University Press. https://doi.org/10.1215/S0012-7094-94-07619-9
chicago: Erdös, László. “Estimates on Stochastic Oscillatory Integrals and on the
Heat Kernel of the Magnetic Schrödinger Operator.” Duke Mathematical Journal.
Duke University Press, 1994. https://doi.org/10.1215/S0012-7094-94-07619-9.
ieee: L. Erdös, “Estimates on stochastic oscillatory integrals and on the heat kernel
of the magnetic Schrödinger operator,” Duke Mathematical Journal, vol.
76, no. 2. Duke University Press, pp. 541–566, 1994.
ista: Erdös L. 1994. Estimates on stochastic oscillatory integrals and on the heat
kernel of the magnetic Schrödinger operator. Duke Mathematical Journal. 76(2),
541–566.
mla: Erdös, László. “Estimates on Stochastic Oscillatory Integrals and on the Heat
Kernel of the Magnetic Schrödinger Operator.” Duke Mathematical Journal,
vol. 76, no. 2, Duke University Press, 1994, pp. 541–66, doi:10.1215/S0012-7094-94-07619-9.
short: L. Erdös, Duke Mathematical Journal 76 (1994) 541–566.
date_created: 2018-12-11T11:59:13Z
date_published: 1994-11-01T00:00:00Z
date_updated: 2022-06-03T11:59:06Z
day: '01'
doi: 10.1215/S0012-7094-94-07619-9
extern: '1'
intvolume: ' 76'
issue: '2'
language:
- iso: eng
main_file_link:
- url: https://projecteuclid.org/journals/duke-mathematical-journal/volume-76/issue-2/Estimates-on-stochastic-oscillatory-integrals-and-on-the-heat-kernel/10.1215/S0012-7094-94-07619-9.short
month: '11'
oa_version: None
page: 541 - 566
publication: Duke Mathematical Journal
publication_identifier:
issn:
- 0012-7094
publication_status: published
publisher: Duke University Press
publist_id: '4183'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Estimates on stochastic oscillatory integrals and on the heat kernel of the
magnetic Schrödinger operator
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 76
year: '1994'
...
---
_id: '1949'
abstract:
- lang: eng
text: H+-transhydrogenase (H+-Thase) and NADP-linked isocitrate dehydrogenase (NADP-ICDH)
are very active in animal mitochondria but their physiological function is only
poorly understood. This is especially so in the case of the heart and muscle,
where there are no major consumers of NADPH. We propose here that H+-Thase and
NADP-ICDH have a combined function in the fine regulation of the activity of the
tricarboxylic acid (TCA) cycle, providing enhanced sensitivy to changes in energy
demand. This is achieved through cycling of substrates by NAD-linked ICDH, NADP-linked
ICDH and H+-Thase. It is proposed that NAD-ICDH operates in the forward direction
of the TCA cycle, but NADP-ICDH is driven in reverse by elevated levels of NADPH
resulting from the action of the transmembrane proton electrochemical potential
gradient (Δp) on H+-Thase. This has the effect of increasing the sensitivity to
allosteric modifiers of NAD-ICDH (NADH, ADP, ATP, Ca2+ etc), potentially giving
rise to large changes in the net flux from iso-citrate to α-ketoglutarate. Furthermore,
changes in the level of Δp resulting from changes in the demand for ATP would,
via H+-Thase, shift the redox state of the NADP pool and this, in turn, would
lead to a change in the rate of the reaction catalysed by NADP-ICDH and hence
to an additional and complementary effect on the net metabolic flux from isocitrate
to α-ketoglutarate. Other consequences of this substrate cycle are, (i) the production
of heat at the expense of Δp, which may contribute to thermoregulation in the
animal, and (ii) an increased rate of dissipation of Δp (leak).
acknowledgement: LAS is grateful to the Wellcome Trust for a fellowship. We should
like to thank Prof. R.M. Denton for discussion.
article_processing_charge: No
article_type: original
author:
- first_name: Leonid A
full_name: Sazanov, Leonid A
id: 338D39FE-F248-11E8-B48F-1D18A9856A87
last_name: Sazanov
orcid: 0000-0002-0977-7989
- first_name: Julie
full_name: Jackson, Julie
last_name: Jackson
citation:
ama: Sazanov LA, Jackson J. Proton translocating transhydrogenase and NAD- and NADP-linked
isocitrate dehydrogenases operate in a substrate cycle which contributes to fine
regulation of the tricarboxylic acid cycle activity in mitochondria. FEBS Letters.
1994;344(2-3):109-116. doi:10.1016/0014-5793(94)00370-X
apa: Sazanov, L. A., & Jackson, J. (1994). Proton translocating transhydrogenase
and NAD- and NADP-linked isocitrate dehydrogenases operate in a substrate cycle
which contributes to fine regulation of the tricarboxylic acid cycle activity
in mitochondria. FEBS Letters. Elsevier. https://doi.org/10.1016/0014-5793(94)00370-X
chicago: Sazanov, Leonid A, and Julie Jackson. “Proton Translocating Transhydrogenase
and NAD- and NADP-Linked Isocitrate Dehydrogenases Operate in a Substrate Cycle
Which Contributes to Fine Regulation of the Tricarboxylic Acid Cycle Activity
in Mitochondria.” FEBS Letters. Elsevier, 1994. https://doi.org/10.1016/0014-5793(94)00370-X.
ieee: L. A. Sazanov and J. Jackson, “Proton translocating transhydrogenase and NAD-
and NADP-linked isocitrate dehydrogenases operate in a substrate cycle which contributes
to fine regulation of the tricarboxylic acid cycle activity in mitochondria,”
FEBS Letters, vol. 344, no. 2–3. Elsevier, pp. 109–116, 1994.
ista: Sazanov LA, Jackson J. 1994. Proton translocating transhydrogenase and NAD-
and NADP-linked isocitrate dehydrogenases operate in a substrate cycle which contributes
to fine regulation of the tricarboxylic acid cycle activity in mitochondria. FEBS
Letters. 344(2–3), 109–116.
mla: Sazanov, Leonid A., and Julie Jackson. “Proton Translocating Transhydrogenase
and NAD- and NADP-Linked Isocitrate Dehydrogenases Operate in a Substrate Cycle
Which Contributes to Fine Regulation of the Tricarboxylic Acid Cycle Activity
in Mitochondria.” FEBS Letters, vol. 344, no. 2–3, Elsevier, 1994, pp.
109–16, doi:10.1016/0014-5793(94)00370-X.
short: L.A. Sazanov, J. Jackson, FEBS Letters 344 (1994) 109–116.
date_created: 2018-12-11T11:54:52Z
date_published: 1994-05-16T00:00:00Z
date_updated: 2022-06-09T13:21:50Z
day: '16'
doi: 10.1016/0014-5793(94)00370-X
extern: '1'
external_id:
pmid:
- '8187868'
intvolume: ' 344'
issue: 2-3
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://febs.onlinelibrary.wiley.com/doi/abs/10.1016/0014-5793%2894%2900370-X
month: '05'
oa: 1
oa_version: Published Version
page: 109 - 116
pmid: 1
publication: FEBS Letters
publication_identifier:
issn:
- 0014-5793
publication_status: published
publisher: Elsevier
publist_id: '5134'
quality_controlled: '1'
status: public
title: Proton translocating transhydrogenase and NAD- and NADP-linked isocitrate dehydrogenases
operate in a substrate cycle which contributes to fine regulation of the tricarboxylic
acid cycle activity in mitochondria
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 344
year: '1994'
...
---
_id: '1953'
abstract:
- lang: eng
text: The respiratory burst induced by phorbol myristate acetate in mouse macrophages
was inhibited by ultra-low doses (10-15 -10-13 M) of an opioid peptide [d-Ala2]
methionine enkephalinamide. The effect disappeared at concentrations above and
below this range. The inhibition approached 50% and was statistically significant
(P < 0.001). Increasing the time of the opioid incubation with cells brought
about a shift in the maximal effect to lower concentrations of the opioid (from
10-13 to 5 · 10-15 M) and led to a decrease in the value of the effect, fully
in accord with the previously proposed adaptation mechanism of the action of ultra-low
doses.
article_processing_charge: No
article_type: original
author:
- first_name: Alexander
full_name: Efanov, Alexander
last_name: Efanov
- first_name: Aleksei
full_name: Koshkin, Aleksei
last_name: Koshkin
- first_name: Leonid A
full_name: Sazanov, Leonid A
id: 338D39FE-F248-11E8-B48F-1D18A9856A87
last_name: Sazanov
orcid: 0000-0002-0977-7989
- first_name: O I
full_name: Borodulina, O I
last_name: Borodulina
- first_name: Sergei
full_name: Varfolomeev, Sergei
last_name: Varfolomeev
- first_name: Sergei
full_name: Zaǐtsev, Sergei
last_name: Zaǐtsev
citation:
ama: Efanov A, Koshkin A, Sazanov LA, Borodulina OI, Varfolomeev S, Zaǐtsev S. Inhibition
of the respiratory burst in mouse macrophages by ultra-low doses of an opioid
peptide is consistent with a possible adaptation mechanism. FEBS Letters.
1994;355(2):114-116. doi:10.1016/0014-5793(94)01109-5
apa: Efanov, A., Koshkin, A., Sazanov, L. A., Borodulina, O. I., Varfolomeev, S.,
& Zaǐtsev, S. (1994). Inhibition of the respiratory burst in mouse macrophages
by ultra-low doses of an opioid peptide is consistent with a possible adaptation
mechanism. FEBS Letters. Elsevier. https://doi.org/10.1016/0014-5793(94)01109-5
chicago: Efanov, Alexander, Aleksei Koshkin, Leonid A Sazanov, O I Borodulina, Sergei
Varfolomeev, and Sergei Zaǐtsev. “Inhibition of the Respiratory Burst in Mouse
Macrophages by Ultra-Low Doses of an Opioid Peptide Is Consistent with a Possible
Adaptation Mechanism.” FEBS Letters. Elsevier, 1994. https://doi.org/10.1016/0014-5793(94)01109-5.
ieee: A. Efanov, A. Koshkin, L. A. Sazanov, O. I. Borodulina, S. Varfolomeev, and
S. Zaǐtsev, “Inhibition of the respiratory burst in mouse macrophages by ultra-low
doses of an opioid peptide is consistent with a possible adaptation mechanism,”
FEBS Letters, vol. 355, no. 2. Elsevier, pp. 114–116, 1994.
ista: Efanov A, Koshkin A, Sazanov LA, Borodulina OI, Varfolomeev S, Zaǐtsev S.
1994. Inhibition of the respiratory burst in mouse macrophages by ultra-low doses
of an opioid peptide is consistent with a possible adaptation mechanism. FEBS
Letters. 355(2), 114–116.
mla: Efanov, Alexander, et al. “Inhibition of the Respiratory Burst in Mouse Macrophages
by Ultra-Low Doses of an Opioid Peptide Is Consistent with a Possible Adaptation
Mechanism.” FEBS Letters, vol. 355, no. 2, Elsevier, 1994, pp. 114–16,
doi:10.1016/0014-5793(94)01109-5.
short: A. Efanov, A. Koshkin, L.A. Sazanov, O.I. Borodulina, S. Varfolomeev, S.
Zaǐtsev, FEBS Letters 355 (1994) 114–116.
date_created: 2018-12-11T11:54:53Z
date_published: 1994-11-28T00:00:00Z
date_updated: 2022-06-09T12:58:57Z
day: '28'
doi: 10.1016/0014-5793(94)01109-5
extern: '1'
external_id:
pmid:
- '7982481'
intvolume: ' 355'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://febs.onlinelibrary.wiley.com/doi/abs/10.1016/0014-5793%2894%2901109-5
month: '11'
oa: 1
oa_version: Published Version
page: 114 - 116
pmid: 1
publication: FEBS Letters
publication_identifier:
issn:
- 0014-5793
publication_status: published
publisher: Elsevier
publist_id: '5133'
quality_controlled: '1'
status: public
title: Inhibition of the respiratory burst in mouse macrophages by ultra-low doses
of an opioid peptide is consistent with a possible adaptation mechanism
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 355
year: '1994'
...
---
_id: '4586'
abstract:
- lang: eng
text: 'Fairness is a mathematical abstraction: in a multiprogramming environment,
fairness abstracts the details of admissible (“fair”) schedulers; in a distributed
environment, fairness abstracts the speeds of independent processors. We argue
that the standard definition of fairness often is unnecessarily weak and can be
replaced by the stronger, yet still abstract, notion of finitary fairness. While
standard weak fairness requires that no enabled transition is postponed forever,
finitary weak fairness requires that for every run of a system there is an unknown
bound k such that no enabled transition is postponed more than k consecutive times.
In general, the finitary restriction fin(F) of any given fairness assumption F
is the union of all w-regular safety properties that are contained in F. The adequacy
of the proposed abstraction is demonstrated in two ways. Suppose that we prove
a program property under the assumption of finitary fairness. In a multiprogramming
environment, the program then satisfies the property for all fair finite-state
schedulers. In a distributed environment, the program then satisfies the property
for all choices of lower and upper bounds on the speeds (or timings) of processors'
article_processing_charge: No
author:
- first_name: Rajeev
full_name: Alur, Rajeev
last_name: Alur
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
citation:
ama: 'Alur R, Henzinger TA. Finitary fairness. In: Proceedings 9th Annual IEEE
Symposium on Logic in Computer Science. IEEE; 1994:52-61. doi:10.1109/LICS.1994.316087 '
apa: 'Alur, R., & Henzinger, T. A. (1994). Finitary fairness. In Proceedings
9th Annual IEEE Symposium on Logic in Computer Science (pp. 52–61). Paris,
France: IEEE. https://doi.org/10.1109/LICS.1994.316087
'
chicago: Alur, Rajeev, and Thomas A Henzinger. “Finitary Fairness.” In Proceedings
9th Annual IEEE Symposium on Logic in Computer Science, 52–61. IEEE, 1994.
https://doi.org/10.1109/LICS.1994.316087
.
ieee: R. Alur and T. A. Henzinger, “Finitary fairness,” in Proceedings 9th Annual
IEEE Symposium on Logic in Computer Science, Paris, France, 1994, pp. 52–61.
ista: 'Alur R, Henzinger TA. 1994. Finitary fairness. Proceedings 9th Annual IEEE
Symposium on Logic in Computer Science. LICS: Logic in Computer Science, 52–61.'
mla: Alur, Rajeev, and Thomas A. Henzinger. “Finitary Fairness.” Proceedings
9th Annual IEEE Symposium on Logic in Computer Science, IEEE, 1994, pp. 52–61,
doi:10.1109/LICS.1994.316087
.
short: R. Alur, T.A. Henzinger, in:, Proceedings 9th Annual IEEE Symposium on Logic
in Computer Science, IEEE, 1994, pp. 52–61.
conference:
end_date: "\t1994-07-07"
location: Paris, France
name: 'LICS: Logic in Computer Science'
start_date: 1994-07-04
date_created: 2018-12-11T12:09:37Z
date_published: 1994-01-01T00:00:00Z
date_updated: 2022-06-02T08:45:57Z
day: '01'
doi: '10.1109/LICS.1994.316087 '
extern: '1'
language:
- iso: eng
main_file_link:
- url: https://ieeexplore.ieee.org/document/316087
month: '01'
oa_version: None
page: 52 - 61
publication: Proceedings 9th Annual IEEE Symposium on Logic in Computer Science
publication_identifier:
issn:
- 0018-9162
publication_status: published
publisher: IEEE
publist_id: '119'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Finitary fairness
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '1994'
...
---
_id: '4590'
abstract:
- lang: eng
text: 'We introduce a temporal logic for the specification of real-time systems.
Our logic, TPTL, employs a novel quantifier construct for referencing time: the
"freeze" quantifier binds a variable to the time of the local temporal
context. TPTL is both a natural language for specification and a suitable formalism
for verification. We present a tableau-based decision procedure and a model-checking
algorithm for TPTL. Several generalizations of TPTL are shown to be highly undecidable.'
acknowledgement: The authors thank Rance Cleaveland, Limor Fix, David Karr, Peter
Kopke, Fred Schneider, and Bernhard Steffen for helpful comments.
alternative_title:
- AMAST Series in Computing
article_processing_charge: No
author:
- first_name: Rajeev
full_name: Alur, Rajeev
last_name: Alur
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
citation:
ama: 'Alur R, Henzinger TA. Real-time system = discrete system + clock variables.
In: Rus T, Rattray C, eds. Theories and Experiences for Real-Time System Development.
Vol 2. AMAST Series in Computing. World Scientific Publishing; 1994:1-29. doi:10.1142/9789812831583_0001'
apa: Alur, R., & Henzinger, T. A. (1994). Real-time system = discrete system
+ clock variables. In T. Rus & C. Rattray (Eds.), Theories and Experiences
for Real-Time System Development (Vol. 2, pp. 1–29). World Scientific Publishing.
https://doi.org/10.1142/9789812831583_0001
chicago: Alur, Rajeev, and Thomas A Henzinger. “Real-Time System = Discrete System
+ Clock Variables.” In Theories and Experiences for Real-Time System Development,
edited by Teodor Rus and Charles Rattray, 2:1–29. AMAST Series in Computing. World
Scientific Publishing, 1994. https://doi.org/10.1142/9789812831583_0001.
ieee: R. Alur and T. A. Henzinger, “Real-time system = discrete system + clock variables,”
in Theories and Experiences for Real-Time System Development, vol. 2, T.
Rus and C. Rattray, Eds. World Scientific Publishing, 1994, pp. 1–29.
ista: 'Alur R, Henzinger TA. 1994.Real-time system = discrete system + clock variables.
In: Theories and Experiences for Real-Time System Development. AMAST Series in
Computing, vol. 2, 1–29.'
mla: Alur, Rajeev, and Thomas A. Henzinger. “Real-Time System = Discrete System
+ Clock Variables.” Theories and Experiences for Real-Time System Development,
edited by Teodor Rus and Charles Rattray, vol. 2, World Scientific Publishing,
1994, pp. 1–29, doi:10.1142/9789812831583_0001.
short: R. Alur, T.A. Henzinger, in:, T. Rus, C. Rattray (Eds.), Theories and Experiences
for Real-Time System Development, World Scientific Publishing, 1994, pp. 1–29.
date_created: 2018-12-11T12:09:38Z
date_published: 1994-01-01T00:00:00Z
date_updated: 2022-06-02T08:07:57Z
day: '01'
doi: 10.1142/9789812831583_0001
editor:
- first_name: Teodor
full_name: Rus, Teodor
last_name: Rus
- first_name: Charles
full_name: Rattray, Charles
last_name: Rattray
extern: '1'
intvolume: ' 2'
keyword:
- real-time systems
- clock variables
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/article/10.1007/s100090050007
month: '01'
oa_version: None
page: 1 - 29
publication: Theories and Experiences for Real-Time System Development
publication_identifier:
isbn:
- ' 9789810219239'
publication_status: published
publisher: World Scientific Publishing
publist_id: '117'
quality_controlled: '1'
series_title: AMAST Series in Computing
status: public
title: Real-time system = discrete system + clock variables
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 2
year: '1994'
...
---
_id: '4591'
abstract:
- lang: eng
text: 'We introduce a temporal logic for the specification of real-time systems.
Our logic, TPTL, employs a novel quantifier construct for referencing time: the
freeze quantifier binds a variable to the time of the local temporal context.
TPTL is both a natural language for specification and a suitable formalism for
verification. We present a tableau-based decision procedure and a model-checking
algorithm for TPTL. Several generalizations of TPTL are shown to be highly undecidable.'
acknowledgement: "We thank Zohar Manna, Amir Pnueli, and David Dill for their guidance.
Moshe Vardi and Joe Halpern gave us very helpful advice for refining our undecidability
results; in particular, they pointed out to us the completeness of a problem on
Turing machines.\r\n"
article_processing_charge: No
article_type: original
author:
- first_name: Rajeev
full_name: Alur, Rajeev
last_name: Alur
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
citation:
ama: Alur R, Henzinger TA. A really temporal logic. Journal of the ACM. 1994;41(1):181-204.
doi:10.1145/174644.174651
apa: Alur, R., & Henzinger, T. A. (1994). A really temporal logic. Journal
of the ACM. ACM. https://doi.org/10.1145/174644.174651
chicago: Alur, Rajeev, and Thomas A Henzinger. “A Really Temporal Logic.” Journal
of the ACM. ACM, 1994. https://doi.org/10.1145/174644.174651.
ieee: R. Alur and T. A. Henzinger, “A really temporal logic,” Journal of the
ACM, vol. 41, no. 1. ACM, pp. 181–204, 1994.
ista: Alur R, Henzinger TA. 1994. A really temporal logic. Journal of the ACM. 41(1),
181–204.
mla: Alur, Rajeev, and Thomas A. Henzinger. “A Really Temporal Logic.” Journal
of the ACM, vol. 41, no. 1, ACM, 1994, pp. 181–204, doi:10.1145/174644.174651.
short: R. Alur, T.A. Henzinger, Journal of the ACM 41 (1994) 181–204.
date_created: 2018-12-11T12:09:38Z
date_published: 1994-01-01T00:00:00Z
date_updated: 2022-06-02T08:23:46Z
day: '01'
doi: 10.1145/174644.174651
extern: '1'
intvolume: ' 41'
issue: '1'
language:
- iso: eng
main_file_link:
- url: https://dl.acm.org/doi/10.1145/174644.174651
month: '01'
oa_version: None
page: 181 - 204
publication: Journal of the ACM
publication_identifier:
issn:
- 0004-5411
publication_status: published
publisher: ACM
publist_id: '118'
quality_controlled: '1'
scopus_import: '1'
status: public
title: A really temporal logic
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 41
year: '1994'
...
---
_id: '4614'
abstract:
- lang: eng
text: "We develop a theory of equivalences for timed systems. Two systems are equivalent
iff external observers cannot observe differences in their behavior. The notion
of equivalence depends, therefore, on the distinguishing power of the observers.
The power of an observer to measure time results in untimed, clock, and timed
equivalences: an untimed observer cannot measure the time difference between events;
a clock observer uses a clock to measure time differences with finite precision;
a timed observer is able to measure time differences with arbitrary precision.\r\nWe
show that the distinguishing power of clock observers grows with the number of
observers, and approaches, in the limit, the distinguishing power of a timed observer.
More precisely, given any equivalence for untimed systems, two timed systems are
k-clock congruent, for a nonnegative integer k, iff their compositions with every
environment that uses k clocks are untimed equivalent. Both k-clock bisimulation
congruence and k-clock trace congruence form strict decidable hierarchies that
converge towards the corresponding timed equivalences. Moreover, k-clock bisimulation
congruence and k-clock trace congruence provide an adequate and abstract semantics
for branching-time and linear-time logics with k clocks.\r\nOur results impact
on the verification of timed systems in two ways. First, our decision procedure
for k-clock bisimulation congruence leads to a new, symbolic, decision procedure
for timed bisimilarity. Second, timed trace equivalence is known to be undecidable.
If the number of environment clocks is bounded, however, then our decision procedure
for k-clock trace congruence allows the verification of timed systems in a trace
model."
acknowledgement: ESPRIT BRA project REACT, National Science Foundation under grant
CCR-9200794, United States Air Force Office of Scientific Research contract F49620-93-1-0056
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Rajeev
full_name: Alur, Rajeev
last_name: Alur
- first_name: Costas
full_name: Courcoubetis, Costas
last_name: Courcoubetis
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
citation:
ama: 'Alur R, Courcoubetis C, Henzinger TA. The observational power of clocks. In:
5th International Conference on Concurrency Theory. Vol 836. Schloss Dagstuhl
- Leibniz-Zentrum für Informatik; 1994:162-177. doi:10.1007/BFb0015008'
apa: 'Alur, R., Courcoubetis, C., & Henzinger, T. A. (1994). The observational
power of clocks. In 5th International Conference on Concurrency Theory
(Vol. 836, pp. 162–177). Uppsala, Sweden: Schloss Dagstuhl - Leibniz-Zentrum für
Informatik. https://doi.org/10.1007/BFb0015008'
chicago: Alur, Rajeev, Costas Courcoubetis, and Thomas A Henzinger. “The Observational
Power of Clocks.” In 5th International Conference on Concurrency Theory,
836:162–77. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 1994. https://doi.org/10.1007/BFb0015008.
ieee: R. Alur, C. Courcoubetis, and T. A. Henzinger, “The observational power of
clocks,” in 5th International Conference on Concurrency Theory, Uppsala,
Sweden, 1994, vol. 836, pp. 162–177.
ista: 'Alur R, Courcoubetis C, Henzinger TA. 1994. The observational power of clocks.
5th International Conference on Concurrency Theory. CONCUR: Concurrency Theory,
LNCS, vol. 836, 162–177.'
mla: Alur, Rajeev, et al. “The Observational Power of Clocks.” 5th International
Conference on Concurrency Theory, vol. 836, Schloss Dagstuhl - Leibniz-Zentrum
für Informatik, 1994, pp. 162–77, doi:10.1007/BFb0015008.
short: R. Alur, C. Courcoubetis, T.A. Henzinger, in:, 5th International Conference
on Concurrency Theory, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 1994,
pp. 162–177.
conference:
end_date: 1994-08-25
location: Uppsala, Sweden
name: 'CONCUR: Concurrency Theory'
start_date: 1994-08-22
date_created: 2018-12-11T12:09:46Z
date_published: 1994-01-01T00:00:00Z
date_updated: 2022-06-02T07:41:46Z
day: '01'
doi: 10.1007/BFb0015008
extern: '1'
intvolume: ' 836'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/chapter/10.1007/BFb0015008
month: '01'
oa_version: None
page: 162 - 177
publication: 5th International Conference on Concurrency Theory
publication_identifier:
isbn:
- '3540583297'
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
publist_id: '93'
quality_controlled: '1'
status: public
title: The observational power of clocks
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 836
year: '1994'
...