[{"status":"public","type":"journal_article","pmid":1,"author":[{"id":"338D39FE-F248-11E8-B48F-1D18A9856A87","last_name":"Sazanov","orcid":"0000-0002-0977-7989","first_name":"Leonid A","full_name":"Sazanov, Leonid A"},{"last_name":"Jackson","first_name":"Julie","full_name":"Jackson, Julie"}],"publication_identifier":{"issn":["0005-2728"]},"month":"09","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","day":"13","main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/000527289390177H?via%3Dihub"}],"oa_version":"None","language":[{"iso":"eng"}],"publication":"Biochimica et Biophysica Acta - Bioenergetics","article_processing_charge":"No","issue":"2","date_updated":"2022-06-01T12:51:32Z","title":"Activation and inhibition of mitochondrial transhydrogenase by metal ions","scopus_import":"1","intvolume":"      1144","date_published":"1993-09-13T00:00:00Z","publisher":"Elsevier","quality_controlled":"1","volume":1144,"page":"225 - 228","extern":"1","publication_status":"published","abstract":[{"lang":"eng","text":"Mitochondrial transhydrogenase has been reported previously to be inhibited by high, rather non-physiological concentrations (in the range of 2-20 mM) of divalent cations. We show that the enzyme could be activated by low (from about 1 μM to 1 mM) concentrations of Ca2+ and Mg2+, which are within physiological range. These results bring in line the effects observed with mitochondrial enzyme to the findings with bacterial transhydrogenases. The activation of transhydrogenase by divalent cations is interpreted as an increase in affinity of the NADP(H)-binding site of the enzyme-NAD(H) complex. Reported effects of the metal ions could be important for the enzyme function in vivo."}],"external_id":{"pmid":["8369341 "]},"article_type":"original","_id":"1947","doi":"10.1016/0005-2728(93)90177-H","year":"1993","acknowledgement":"This work was supported by a Wellcome Trust fellowship to L.A.S. ","citation":{"ama":"Sazanov LA, Jackson J. Activation and inhibition of mitochondrial transhydrogenase by metal ions. <i>Biochimica et Biophysica Acta - Bioenergetics</i>. 1993;1144(2):225-228. doi:<a href=\"https://doi.org/10.1016/0005-2728(93)90177-H\">10.1016/0005-2728(93)90177-H</a>","ieee":"L. A. Sazanov and J. Jackson, “Activation and inhibition of mitochondrial transhydrogenase by metal ions,” <i>Biochimica et Biophysica Acta - Bioenergetics</i>, vol. 1144, no. 2. Elsevier, pp. 225–228, 1993.","short":"L.A. Sazanov, J. Jackson, Biochimica et Biophysica Acta - Bioenergetics 1144 (1993) 225–228.","ista":"Sazanov LA, Jackson J. 1993. Activation and inhibition of mitochondrial transhydrogenase by metal ions. Biochimica et Biophysica Acta - Bioenergetics. 1144(2), 225–228.","chicago":"Sazanov, Leonid A, and Julie Jackson. “Activation and Inhibition of Mitochondrial Transhydrogenase by Metal Ions.” <i>Biochimica et Biophysica Acta - Bioenergetics</i>. Elsevier, 1993. <a href=\"https://doi.org/10.1016/0005-2728(93)90177-H\">https://doi.org/10.1016/0005-2728(93)90177-H</a>.","mla":"Sazanov, Leonid A., and Julie Jackson. “Activation and Inhibition of Mitochondrial Transhydrogenase by Metal Ions.” <i>Biochimica et Biophysica Acta - Bioenergetics</i>, vol. 1144, no. 2, Elsevier, 1993, pp. 225–28, doi:<a href=\"https://doi.org/10.1016/0005-2728(93)90177-H\">10.1016/0005-2728(93)90177-H</a>.","apa":"Sazanov, L. A., &#38; Jackson, J. (1993). Activation and inhibition of mitochondrial transhydrogenase by metal ions. <i>Biochimica et Biophysica Acta - Bioenergetics</i>. Elsevier. <a href=\"https://doi.org/10.1016/0005-2728(93)90177-H\">https://doi.org/10.1016/0005-2728(93)90177-H</a>"},"date_created":"2018-12-11T11:54:52Z","publist_id":"5136"},{"intvolume":"        21","scopus_import":"1","title":"Possible functions of the NADP-linked isocitrate dehydrogenase and H+ -transhydrogenase in heart mitochondria ","article_processing_charge":"No","issue":"3","date_updated":"2022-06-01T13:17:02Z","publication":"Biochemical Society Transactions","language":[{"iso":"eng"}],"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","oa_version":"None","day":"01","main_file_link":[{"url":"https://portlandpress.com/biochemsoctrans/article-abstract/21/3/260S/83260/Possible-functions-of-the-NADP-linked-isocitrate?redirectedFrom=fulltext"}],"month":"01","publication_identifier":{"issn":["0300-5127"]},"author":[{"orcid":"0000-0002-0977-7989","last_name":"Sazanov","id":"338D39FE-F248-11E8-B48F-1D18A9856A87","first_name":"Leonid A","full_name":"Sazanov, Leonid A"},{"last_name":"Jackson","full_name":"Jackson, Julie","first_name":"Julie"}],"status":"public","type":"journal_article","pmid":1,"citation":{"short":"L.A. Sazanov, J. Jackson, Biochemical Society Transactions 21 (1993) 260.","ama":"Sazanov LA, Jackson J. Possible functions of the NADP-linked isocitrate dehydrogenase and H+ -transhydrogenase in heart mitochondria . <i>Biochemical Society Transactions</i>. 1993;21(3):260. doi:<a href=\"https://doi.org/10.1042/bst021260s\">10.1042/bst021260s</a>","ieee":"L. A. Sazanov and J. Jackson, “Possible functions of the NADP-linked isocitrate dehydrogenase and H+ -transhydrogenase in heart mitochondria ,” <i>Biochemical Society Transactions</i>, vol. 21, no. 3. Portland Press, p. 260, 1993.","ista":"Sazanov LA, Jackson J. 1993. Possible functions of the NADP-linked isocitrate dehydrogenase and H+ -transhydrogenase in heart mitochondria . Biochemical Society Transactions. 21(3), 260.","chicago":"Sazanov, Leonid A, and Julie Jackson. “Possible Functions of the NADP-Linked Isocitrate Dehydrogenase and H+ -Transhydrogenase in Heart Mitochondria .” <i>Biochemical Society Transactions</i>. Portland Press, 1993. <a href=\"https://doi.org/10.1042/bst021260s\">https://doi.org/10.1042/bst021260s</a>.","mla":"Sazanov, Leonid A., and Julie Jackson. “Possible Functions of the NADP-Linked Isocitrate Dehydrogenase and H+ -Transhydrogenase in Heart Mitochondria .” <i>Biochemical Society Transactions</i>, vol. 21, no. 3, Portland Press, 1993, p. 260, doi:<a href=\"https://doi.org/10.1042/bst021260s\">10.1042/bst021260s</a>.","apa":"Sazanov, L. A., &#38; Jackson, J. (1993). Possible functions of the NADP-linked isocitrate dehydrogenase and H+ -transhydrogenase in heart mitochondria . <i>Biochemical Society Transactions</i>. Portland Press. <a href=\"https://doi.org/10.1042/bst021260s\">https://doi.org/10.1042/bst021260s</a>"},"date_created":"2018-12-11T11:54:52Z","publist_id":"5137","year":"1993","acknowledgement":"We acknowledge financial support from the Wellcome Trust (fellowship to L.A.S) ","doi":"10.1042/bst021260s","article_type":"original","_id":"1948","external_id":{"pmid":["8224412 "]},"publication_status":"published","volume":21,"quality_controlled":"1","page":"260","extern":"1","date_published":"1993-01-01T00:00:00Z","publisher":"Portland Press"},{"external_id":{"pmid":["8131888"]},"publication_status":"published","volume":21,"quality_controlled":"1","extern":"1","page":"1010 - 1013","date_published":"1993-11-01T00:00:00Z","publisher":"Portland Press","citation":{"apa":"Jackson, J., Cotton, N. P. J., Williams, R., Bizouarn, T., Hutton, M., Sazanov, L. A., &#38; Thomas, C. (1993). Proton-translocating transhydrogenase in bacteria. <i>Biochemical Society Transactions</i>. Portland Press. <a href=\"https://doi.org/10.1042/bst0211010\">https://doi.org/10.1042/bst0211010</a>","ista":"Jackson J, Cotton NPJ, Williams R, Bizouarn T, Hutton M, Sazanov LA, Thomas C. 1993. Proton-translocating transhydrogenase in bacteria. Biochemical Society Transactions. 21(4), 1010–1013.","chicago":"Jackson, Julie, N P J Cotton, Ross Williams, Tania Bizouarn, Mike Hutton, Leonid A Sazanov, and Christopher Thomas. “Proton-Translocating Transhydrogenase in Bacteria.” <i>Biochemical Society Transactions</i>. Portland Press, 1993. <a href=\"https://doi.org/10.1042/bst0211010\">https://doi.org/10.1042/bst0211010</a>.","mla":"Jackson, Julie, et al. “Proton-Translocating Transhydrogenase in Bacteria.” <i>Biochemical Society Transactions</i>, vol. 21, no. 4, Portland Press, 1993, pp. 1010–13, doi:<a href=\"https://doi.org/10.1042/bst0211010\">10.1042/bst0211010</a>.","ieee":"J. Jackson <i>et al.</i>, “Proton-translocating transhydrogenase in bacteria,” <i>Biochemical Society Transactions</i>, vol. 21, no. 4. Portland Press, pp. 1010–1013, 1993.","ama":"Jackson J, Cotton NPJ, Williams R, et al. Proton-translocating transhydrogenase in bacteria. <i>Biochemical Society Transactions</i>. 1993;21(4):1010-1013. doi:<a href=\"https://doi.org/10.1042/bst0211010\">10.1042/bst0211010</a>","short":"J. Jackson, N.P.J. Cotton, R. Williams, T. Bizouarn, M. Hutton, L.A. Sazanov, C. Thomas, Biochemical Society Transactions 21 (1993) 1010–1013."},"date_created":"2018-12-11T11:54:52Z","publist_id":"5135","year":"1993","doi":"10.1042/bst0211010","article_type":"original","_id":"1950","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","main_file_link":[{"url":"https://portlandpress.com/biochemsoctrans/article-abstract/21/4/1010/86733/Proton-translocating-transhydrogenase-in-bacteria?redirectedFrom=fulltext"}],"oa_version":"None","day":"01","publication_identifier":{"issn":["0300-5127"]},"month":"11","author":[{"first_name":"Julie","full_name":"Jackson, Julie","last_name":"Jackson"},{"first_name":"N P J","full_name":"Cotton, N P J","last_name":"Cotton"},{"first_name":"Ross","full_name":"Williams, Ross","last_name":"Williams"},{"full_name":"Bizouarn, Tania","first_name":"Tania","last_name":"Bizouarn"},{"first_name":"Mike","full_name":"Hutton, Mike","last_name":"Hutton"},{"orcid":"0000-0002-0977-7989","last_name":"Sazanov","id":"338D39FE-F248-11E8-B48F-1D18A9856A87","first_name":"Leonid A","full_name":"Sazanov, Leonid A"},{"last_name":"Thomas","full_name":"Thomas, Christopher","first_name":"Christopher"}],"status":"public","type":"journal_article","pmid":1,"intvolume":"        21","scopus_import":"1","title":"Proton-translocating transhydrogenase in bacteria","issue":"4","article_processing_charge":"No","date_updated":"2022-06-01T12:16:19Z","publication":"Biochemical Society Transactions","language":[{"iso":"eng"}]},{"date_created":"2018-12-11T11:57:57Z","publist_id":"4414","citation":{"apa":"Ohishi, H., Shigemoto, R., Nakanishi, S., &#38; Mizuno, N. (1993).  Distribution of the mRNA for a metabotropic glutamate receptor (mGluR3) in the rat brain: An in situ hybridization study. <i>Journal of Comparative Neurology</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1002/cne.903350209\">https://doi.org/10.1002/cne.903350209</a>","chicago":"Ohishi, Hitoshi, Ryuichi Shigemoto, Shigetada Nakanishi, and Noboru Mizuno. “ Distribution of the MRNA for a Metabotropic Glutamate Receptor (MGluR3) in the Rat Brain: An in Situ Hybridization Study.” <i>Journal of Comparative Neurology</i>. Wiley-Blackwell, 1993. <a href=\"https://doi.org/10.1002/cne.903350209\">https://doi.org/10.1002/cne.903350209</a>.","mla":"Ohishi, Hitoshi, et al. “ Distribution of the MRNA for a Metabotropic Glutamate Receptor (MGluR3) in the Rat Brain: An in Situ Hybridization Study.” <i>Journal of Comparative Neurology</i>, vol. 335, no. 2, Wiley-Blackwell, 1993, pp. 252–66, doi:<a href=\"https://doi.org/10.1002/cne.903350209\">10.1002/cne.903350209</a>.","ista":"Ohishi H, Shigemoto R, Nakanishi S, Mizuno N. 1993.  Distribution of the mRNA for a metabotropic glutamate receptor (mGluR3) in the rat brain: An in situ hybridization study. Journal of Comparative Neurology. 335(2), 252–266.","short":"H. Ohishi, R. Shigemoto, S. Nakanishi, N. Mizuno, Journal of Comparative Neurology 335 (1993) 252–266.","ama":"Ohishi H, Shigemoto R, Nakanishi S, Mizuno N.  Distribution of the mRNA for a metabotropic glutamate receptor (mGluR3) in the rat brain: An in situ hybridization study. <i>Journal of Comparative Neurology</i>. 1993;335(2):252-266. doi:<a href=\"https://doi.org/10.1002/cne.903350209\">10.1002/cne.903350209</a>","ieee":"H. Ohishi, R. Shigemoto, S. Nakanishi, and N. Mizuno, “ Distribution of the mRNA for a metabotropic glutamate receptor (mGluR3) in the rat brain: An in situ hybridization study,” <i>Journal of Comparative Neurology</i>, vol. 335, no. 2. Wiley-Blackwell, pp. 252–266, 1993."},"year":"1993","acknowledgement":"We are grateful for the photographic help of Mr. Akira Uesugi and the support of Drs. Satoru Fukuchi, Toshio Fukuda, Ritsu Hayashi, Mizuho Katsurada, Yutaka Kitani, Keiko Kumagai, Toshihiko  Kuroda,  Hiroshi Matsubara, Hiroshi Matsushima, Chisato Minakuchi, Masatoshi Nishio, Gonpei Niwa,  Hajime Oda, Masahiko Ohbayashi, Sei-ichi Ohbayashi, Hiroyasu Ohtsuka, Shigeo Tamaki, Eizo Watan- abe, Kazuo Yoshino, and Toshiaki Yoshino. This work was supported in  part by grants-in-aid from the Ministry of Education, Science, and Culture of Japan.","doi":"10.1002/cne.903350209","article_type":"original","_id":"2487","abstract":[{"text":"Distribution of the mRNA for a metabotropic glutamate receptor, mGluR3, which is coupled to the inhibitory cAMP cascade, was examined in the central nervous system of the adult albino rat by in situ hybridization. The hybridization signals of mGluR3 were detected not only on neuronal cells but also on many glial cells throughout the brain and spinal cord. In the neuronal cells, prominent expression of mGluR3 mRNA was seen in the thalamic reticular nucleus. Moderately labeled neurons were seen in the anterior olfactory nucleus, cerebral neo- and mesocortical regions, lateral amygdaloid nucleus, ventral part of the basolateral amygdaloid nucleus, dorsal endopiriform nucleus, supraoptic nucleus, superficial layers of the superior colliculus, inferior colliculus, interpeduncular nucleus, superior olivary nuclei, and Golgi cells in the cerebellar cortex. Weakly labeled neurons were observed in the striatum, nucleus accumbens, ventral pallidum, globus pallidus, entopeduncular nucleus, lateral hypothalamic area, hypothalamic paraventricular nucleus, medial habenular nucleus, anterior pretectal nucleus, Barrington's nucleus, Nucleus O, paragenual nucleus, trigeminal sensory complex, cochlear nuclei, dorsal motor nucleus of the trigeminal nerve, dorsal cap of the inferior olive, spinal dorsal horn, and lamina X of the spinal cord. The stellate cells in the cerebellar cortex, and neurons in the deep cerebellar nuclei were also labeled weakly. The granule cell layer of the dentate gyrus, as a whole, appeared to be labeled intensely, but each of the granule cells was labeled only weakly. No significant labeling was detected in the mitral and tufted cells in the olfactory bulb, hippocampal pyramidal cells, Purkinje and granule cells in the cerebellar cortex, or somatic motoneurons. The distribution of mGluR3 mRNA in particular neurons and glial cells indicates specific roles of mGluR3 in the glutamatergic system of the central nervous system.","lang":"eng"}],"external_id":{"pmid":["8227517"]},"publication_status":"published","quality_controlled":"1","volume":335,"page":"252 - 266","extern":"1","date_published":"1993-09-08T00:00:00Z","publisher":"Wiley-Blackwell","intvolume":"       335","title":" Distribution of the mRNA for a metabotropic glutamate receptor (mGluR3) in the rat brain: An in situ hybridization study","article_processing_charge":"No","issue":"2","date_updated":"2022-06-01T11:58:11Z","publication":"Journal of Comparative Neurology","language":[{"iso":"eng"}],"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","oa_version":"None","main_file_link":[{"url":"https://onlinelibrary.wiley.com/doi/10.1002/cne.903350209"}],"day":"08","publication_identifier":{"issn":["0021-9967"]},"month":"09","author":[{"first_name":"Hitoshi","full_name":"Ohishi, Hitoshi","last_name":"Ohishi"},{"last_name":"Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444","first_name":"Ryuichi","full_name":"Shigemoto, Ryuichi"},{"full_name":"Nakanishi, Shigetada","first_name":"Shigetada","last_name":"Nakanishi"},{"last_name":"Mizuno","full_name":"Mizuno, Noboru","first_name":"Noboru"}],"type":"journal_article","status":"public","pmid":1},{"publist_id":"4362","citation":{"ieee":"Y. Nakajima <i>et al.</i>, “Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4- phosphonobutyrate,” <i>Journal of Biological Chemistry</i>, vol. 268, no. 16. American Society for Biochemistry and Molecular Biology, pp. 11868–11873, 1993.","ama":"Nakajima Y, Iwakabe H, Akazawa C, et al. Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4- phosphonobutyrate. <i>Journal of Biological Chemistry</i>. 1993;268(16):11868-11873. doi:<a href=\"https://doi.org/10.1016/S0021-9258(19)50280-0\">10.1016/S0021-9258(19)50280-0</a>","short":"Y. Nakajima, H. Iwakabe, C. Akazawa, H. Nawa, R. Shigemoto, N. Mizuno, S. Nakanishi, Journal of Biological Chemistry 268 (1993) 11868–11873.","chicago":"Nakajima, Yoshiaki, Hideki Iwakabe, Chihiro Akazawa, Hiroyuki Nawa, Ryuichi Shigemoto, Noboru Mizuno, and Shigetada Nakanishi. “Molecular Characterization of a Novel Retinal Metabotropic Glutamate Receptor MGluR6 with a High Agonist Selectivity for L-2-Amino-4- Phosphonobutyrate.” <i>Journal of Biological Chemistry</i>. American Society for Biochemistry and Molecular Biology, 1993. <a href=\"https://doi.org/10.1016/S0021-9258(19)50280-0\">https://doi.org/10.1016/S0021-9258(19)50280-0</a>.","ista":"Nakajima Y, Iwakabe H, Akazawa C, Nawa H, Shigemoto R, Mizuno N, Nakanishi S. 1993. Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4- phosphonobutyrate. Journal of Biological Chemistry. 268(16), 11868–11873.","mla":"Nakajima, Yoshiaki, et al. “Molecular Characterization of a Novel Retinal Metabotropic Glutamate Receptor MGluR6 with a High Agonist Selectivity for L-2-Amino-4- Phosphonobutyrate.” <i>Journal of Biological Chemistry</i>, vol. 268, no. 16, American Society for Biochemistry and Molecular Biology, 1993, pp. 11868–73, doi:<a href=\"https://doi.org/10.1016/S0021-9258(19)50280-0\">10.1016/S0021-9258(19)50280-0</a>.","apa":"Nakajima, Y., Iwakabe, H., Akazawa, C., Nawa, H., Shigemoto, R., Mizuno, N., &#38; Nakanishi, S. (1993). Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4- phosphonobutyrate. <i>Journal of Biological Chemistry</i>. American Society for Biochemistry and Molecular Biology. <a href=\"https://doi.org/10.1016/S0021-9258(19)50280-0\">https://doi.org/10.1016/S0021-9258(19)50280-0</a>"},"date_created":"2018-12-11T11:58:15Z","acknowledgement":"This work was supported in part by research grants from the Ministry of Education, Science and Culture of Japan, the Ministry of Health and Welfare, the Yamanouchi Foundation for Research on Metabolic Disorders, the Uehara Memorial Foundation, and the Inamori Foundation. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. \r\n\r\nWe are grateful to Akira Uesugi for photographic assistance.","year":"1993","doi":"10.1016/S0021-9258(19)50280-0","_id":"2536","article_type":"original","external_id":{"pmid":["8389366"]},"abstract":[{"lang":"eng","text":"A cDNA clone for a new metabotropic glutamate receptor, termed mGluR6, was isolated from a rat retinal cDNA library by cross-hybridization with the previously isolated cDNA clone for a metabotropic glutamate receptor. The cloned mGluR6 subtype consists of 871 amino acid residues and exhibits a structural architecture common to the metabotropic receptor family, possessing a large extracellular domain preceding the seven putative membrane-spanning domains. mGluR6 shows the highest sequence similarity to mGluR4 among the metabotropic receptor subtypes and inhibits the forskolin- stimulated cyclic AMP accumulation in Chinese hamster ovary cells transfected with the cloned cDNA. mGluR6 potently reacts with L-2-amino-4- phosphonobutyrate (L-AP4) and L-serine-O-phosphate, and the potencies of these compounds are one order of magnitude greater than that of L-glutamate. Blot and in situ hybridization analyses indicated that mGluR6 mRNA is restrictedly expressed in the inner nuclear layer of the retina where ON- bipolar cells are distributed. The metabotropic receptor that responds strongly to L-AP4 and L-serine-O-phosphate in ON-bipolar cells is known to mediate glutamate synaptic transmission between photoreceptor cells and ON- bipolar cells. On the basis of the agonist selectivity of mGluR6 and its specific expression in retinal cells, the physiological role of this receptor subtype in the visual system is discussed."}],"publication_status":"published","extern":"1","page":"11868 - 11873","volume":268,"quality_controlled":"1","publisher":"American Society for Biochemistry and Molecular Biology","date_published":"1993-06-05T00:00:00Z","scopus_import":"1","intvolume":"       268","title":"Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4- phosphonobutyrate","oa":1,"date_updated":"2022-04-26T06:56:15Z","article_processing_charge":"No","issue":"16","publication":"Journal of Biological Chemistry","language":[{"iso":"eng"}],"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1016/S0021-9258(19)50280-0"}],"day":"05","oa_version":"Published Version","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","month":"06","publication_identifier":{"issn":["0021-9258"]},"author":[{"full_name":"Nakajima, Yoshiaki","first_name":"Yoshiaki","last_name":"Nakajima"},{"last_name":"Iwakabe","full_name":"Iwakabe, Hideki","first_name":"Hideki"},{"full_name":"Akazawa, Chihiro","first_name":"Chihiro","last_name":"Akazawa"},{"full_name":"Nawa, Hiroyuki","first_name":"Hiroyuki","last_name":"Nawa"},{"first_name":"Ryuichi","full_name":"Shigemoto, Ryuichi","last_name":"Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444"},{"last_name":"Mizuno","full_name":"Mizuno, Noboru","first_name":"Noboru"},{"last_name":"Nakanishi","full_name":"Nakanishi, Shigetada","first_name":"Shigetada"}],"pmid":1,"type":"journal_article","status":"public"},{"article_type":"original","_id":"2537","doi":"10.1523/JNEUROSCI.13-04-01372.1993","acknowledgement":"We are grateful to Mr. Akira Uesugi for photographic assistance. This work was  supported in part by research grants from the Ministry of Education, Science and Culture of Japan, the Ministry of Health and Welfare of Japan, the Uehara Memorial Foundation, and the Semi Life Science Foundation. ","year":"1993","publist_id":"4361","citation":{"apa":"Tanabe, Y., Nomura, A., Masu, M., Shigemoto, R., Mizuno, N., &#38; Nakanishi, S. (1993). Signal transduction, pharmacological properties, and expression patterns of two rat metabotropic glutamate receptors, mGluR3 and mGluR4. <i>Journal of Neuroscience</i>. Society for Neuroscience. <a href=\"https://doi.org/10.1523/JNEUROSCI.13-04-01372.1993\">https://doi.org/10.1523/JNEUROSCI.13-04-01372.1993</a>","mla":"Tanabe, Yasuto, et al. “Signal Transduction, Pharmacological Properties, and Expression Patterns of Two Rat Metabotropic Glutamate Receptors, MGluR3 and MGluR4.” <i>Journal of Neuroscience</i>, vol. 13, no. 4, Society for Neuroscience, 1993, pp. 1372–78, doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.13-04-01372.1993\">10.1523/JNEUROSCI.13-04-01372.1993</a>.","ista":"Tanabe Y, Nomura A, Masu M, Shigemoto R, Mizuno N, Nakanishi S. 1993. Signal transduction, pharmacological properties, and expression patterns of two rat metabotropic glutamate receptors, mGluR3 and mGluR4. Journal of Neuroscience. 13(4), 1372–1378.","chicago":"Tanabe, Yasuto, Akinori Nomura, Masayuki Masu, Ryuichi Shigemoto, Noboru Mizuno, and Shigetada Nakanishi. “Signal Transduction, Pharmacological Properties, and Expression Patterns of Two Rat Metabotropic Glutamate Receptors, MGluR3 and MGluR4.” <i>Journal of Neuroscience</i>. Society for Neuroscience, 1993. <a href=\"https://doi.org/10.1523/JNEUROSCI.13-04-01372.1993\">https://doi.org/10.1523/JNEUROSCI.13-04-01372.1993</a>.","ieee":"Y. Tanabe, A. Nomura, M. Masu, R. Shigemoto, N. Mizuno, and S. Nakanishi, “Signal transduction, pharmacological properties, and expression patterns of two rat metabotropic glutamate receptors, mGluR3 and mGluR4,” <i>Journal of Neuroscience</i>, vol. 13, no. 4. Society for Neuroscience, pp. 1372–1378, 1993.","ama":"Tanabe Y, Nomura A, Masu M, Shigemoto R, Mizuno N, Nakanishi S. Signal transduction, pharmacological properties, and expression patterns of two rat metabotropic glutamate receptors, mGluR3 and mGluR4. <i>Journal of Neuroscience</i>. 1993;13(4):1372-1378. doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.13-04-01372.1993\">10.1523/JNEUROSCI.13-04-01372.1993</a>","short":"Y. Tanabe, A. Nomura, M. Masu, R. Shigemoto, N. Mizuno, S. Nakanishi, Journal of Neuroscience 13 (1993) 1372–1378."},"date_created":"2018-12-11T11:58:15Z","publisher":"Society for Neuroscience","date_published":"1993-04-01T00:00:00Z","page":"1372 - 1378","extern":"1","quality_controlled":"1","volume":13,"publication_status":"published","external_id":{"pmid":["8463825"]},"abstract":[{"lang":"eng","text":"The metabotropic glutamate receptors are coupled to intracellular signal transduction via G-proteins and consist of a family of at least five different subtypes, termed mGluR1-mGluR5. We studied the signal transduction mechanism and pharmacological characteristics of the rat mGluR3 and mGluR4 subtypes in Chinese hamster ovary cells permanently expressing the cloned receptors. Both mGluR3 and mGluR4 inhibit the forskolin-stimulated accumulation of intracellular cAMP formation in response to agonist interaction. Consistent with the high degree of sequence similarity to mGluR2, mGluR3 closely resembles mGluR2 in its agonist selectivity; the potency rank order of agonists is L-glutamate &gt; trans-1-aminocyclopentane- 1,3-dicarboxylate &gt; ibotenate &gt; quisqualate. mGluR4 is totally different in its agonist specificity from any other member of the metabotropic receptors. This receptor potently reacts with L-2-amino-4-phosphonobutyrate(L-AP4) in a stereo-selective manner and moderately responds to L-serine-O-phosphate. mGluR4 thus corresponds well to the putative L-AP4 receptor characterized from brain preparations. Blot and in situ hybridization analyses indicated that both mRNAs are widely distributed in the rat brain. mGluR3 mRNA is highly expressed in neuronal cells of the cerebral cortex and the caudate- putamen, and in granule cells of the hippocampal dentate gyrus. The expression pattern of mGluR4 mRNA is more restricted, and this expression is prominent in the cerebellum, olfactory bulb, and thalamus. Furthermore, the mGluR3 mRNA, unlike the other mRNAs for the metabotropic receptors, is highly expressed in glial cells throughout the brain regions. The metabotropic glutamate receptor subtypes can thus be classified into three subgroups according to the similarity in their amino acid sequences, signal transduction, and agonist selectivity: mGluR1/mGluR5, mGluR2/mGluR3, and mGluR4. The mRNAs for the individual receptor subtypes, however, show overlapping but distinct patterns of expression in the rat CNS."}],"language":[{"iso":"eng"}],"publication":"Journal of Neuroscience","oa":1,"date_updated":"2022-03-31T14:49:42Z","issue":"4","article_processing_charge":"No","title":"Signal transduction, pharmacological properties, and expression patterns of two rat metabotropic glutamate receptors, mGluR3 and mGluR4","scopus_import":"1","intvolume":"        13","pmid":1,"type":"journal_article","status":"public","author":[{"last_name":"Tanabe","first_name":"Yasuto","full_name":"Tanabe, Yasuto"},{"full_name":"Nomura, Akinori","first_name":"Akinori","last_name":"Nomura"},{"full_name":"Masu, Masayuki","first_name":"Masayuki","last_name":"Masu"},{"orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","first_name":"Ryuichi","full_name":"Shigemoto, Ryuichi"},{"full_name":"Mizuno, Noboru","first_name":"Noboru","last_name":"Mizuno"},{"first_name":"Shigetada","full_name":"Nakanishi, Shigetada","last_name":"Nakanishi"}],"publication_identifier":{"issn":["0270-6474"]},"month":"04","main_file_link":[{"open_access":"1","url":"https://pubmed.ncbi.nlm.nih.gov/8463825/"}],"day":"01","oa_version":"Published Version","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17"},{"year":"1993","acknowledgement":"We thank Ms. Fumiko Kosaka for her excellent technical assistance.","citation":{"apa":"Iwai, M., Hori, S., Shigemoto, R., Kanzaki, H., Mori, T., &#38; Nakanishi, S. (1993). Localization of endothelin receptor messenger ribonucleic acid in the rat ovary and fallopian tube by in situ hybridization. <i>Biology of Reproduction</i>. Society for the Study of Reproduction. <a href=\"https://doi.org/10.1095/biolreprod49.4.675\">https://doi.org/10.1095/biolreprod49.4.675</a>","ista":"Iwai M, Hori S, Shigemoto R, Kanzaki H, Mori T, Nakanishi S. 1993. Localization of endothelin receptor messenger ribonucleic acid in the rat ovary and fallopian tube by in situ hybridization. Biology of Reproduction. 49(4), 675–680.","chicago":"Iwai, Masazumi, Seiji Hori, Ryuichi Shigemoto, Hideharu Kanzaki, Takahide Mori, and Shigetada Nakanishi. “Localization of Endothelin Receptor Messenger Ribonucleic Acid in the Rat Ovary and Fallopian Tube by in Situ Hybridization.” <i>Biology of Reproduction</i>. Society for the Study of Reproduction, 1993. <a href=\"https://doi.org/10.1095/biolreprod49.4.675\">https://doi.org/10.1095/biolreprod49.4.675</a>.","mla":"Iwai, Masazumi, et al. “Localization of Endothelin Receptor Messenger Ribonucleic Acid in the Rat Ovary and Fallopian Tube by in Situ Hybridization.” <i>Biology of Reproduction</i>, vol. 49, no. 4, Society for the Study of Reproduction, 1993, pp. 675–80, doi:<a href=\"https://doi.org/10.1095/biolreprod49.4.675\">10.1095/biolreprod49.4.675</a>.","ieee":"M. Iwai, S. Hori, R. Shigemoto, H. Kanzaki, T. Mori, and S. Nakanishi, “Localization of endothelin receptor messenger ribonucleic acid in the rat ovary and fallopian tube by in situ hybridization,” <i>Biology of Reproduction</i>, vol. 49, no. 4. Society for the Study of Reproduction, pp. 675–680, 1993.","ama":"Iwai M, Hori S, Shigemoto R, Kanzaki H, Mori T, Nakanishi S. Localization of endothelin receptor messenger ribonucleic acid in the rat ovary and fallopian tube by in situ hybridization. <i>Biology of Reproduction</i>. 1993;49(4):675-680. doi:<a href=\"https://doi.org/10.1095/biolreprod49.4.675\">10.1095/biolreprod49.4.675</a>","short":"M. Iwai, S. Hori, R. Shigemoto, H. Kanzaki, T. Mori, S. Nakanishi, Biology of Reproduction 49 (1993) 675–680."},"publist_id":"4359","date_created":"2018-12-11T11:58:16Z","doi":"10.1095/biolreprod49.4.675","_id":"2538","article_type":"original","abstract":[{"lang":"eng","text":"Rat mRNAs encoding two subtypes of the endothelin (ET) receptor (ET(A) and ET(B)) were studied in the rat ovary and fallopian tube by means of Northern blotting and in situ hybridization. The mRNA transcripts for the endothelin- 1-specific type receptor (ET(A)) in pooled RNA from the ovary and fallopian tube were 4.2 and 5.2 kilonucleotides, and that for the nonselective type receptor (ET(B)) was 4.7 kilonucleotides; these were similar to transcripts for endothelin receptors from other tissues. ET(A) mRNA expression was abundant in the muscle cell layer of the fallopian tube, but low in the ovary. On the other hand, ET(B) mRNA was abundant in the granulosa cells in the developing follicles, but low in atretic follicles and absent in the fallopian tube. These results demonstrated that the mRNAs for the two subtypes of the rat endothelin receptor have different expression profiles in the ovary and fallopian tube. ETs may mainly affect the granulosa cells in the dominant follicles as well as the muscle cells of the fallopian tube through ET(B) and ET(A), respectively."}],"external_id":{"pmid":["8218631"]},"publication_status":"published","date_published":"1993-10-01T00:00:00Z","publisher":"Society for the Study of Reproduction","volume":49,"quality_controlled":"1","page":"675 - 680","extern":"1","intvolume":"        49","scopus_import":"1","issue":"4","article_processing_charge":"No","oa":1,"date_updated":"2022-03-31T12:32:51Z","title":"Localization of endothelin receptor messenger ribonucleic acid in the rat ovary and fallopian tube by in situ hybridization","publication":"Biology of Reproduction","language":[{"iso":"eng"}],"publication_identifier":{"issn":["0006-3363"]},"month":"10","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","oa_version":"Published Version","main_file_link":[{"url":"https://academic.oup.com/biolreprod/article/49/4/675/2762375?login=true","open_access":"1"}],"day":"01","author":[{"full_name":"Iwai, Masazumi","first_name":"Masazumi","last_name":"Iwai"},{"full_name":"Hori, Seiji","first_name":"Seiji","last_name":"Hori"},{"orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","full_name":"Shigemoto, Ryuichi","first_name":"Ryuichi"},{"full_name":"Kanzaki, Hideharu","first_name":"Hideharu","last_name":"Kanzaki"},{"last_name":"Mori","first_name":"Takahide","full_name":"Mori, Takahide"},{"full_name":"Nakanishi, Shigetada","first_name":"Shigetada","last_name":"Nakanishi"}],"type":"journal_article","status":"public","pmid":1},{"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","main_file_link":[{"open_access":"1","url":"https://www.jbc.org/article/S0021-9258(18)53849-7/fulltext"}],"day":"05","oa_version":"Published Version","publication_identifier":{"issn":["0021-9258"]},"month":"02","author":[{"full_name":"Ishii, Takahiro","first_name":"Takahiro","last_name":"Ishii"},{"last_name":"Moriyoshi","first_name":"Koki","full_name":"Moriyoshi, Koki"},{"last_name":"Sugihara","first_name":"Hidemitsu","full_name":"Sugihara, Hidemitsu"},{"last_name":"Sakurada","first_name":"Kazuhir","full_name":"Sakurada, Kazuhir"},{"last_name":"Kadotani","full_name":"Kadotani, Hiroshi","first_name":"Hiroshi"},{"full_name":"Yokoi, Mineto","first_name":"Mineto","last_name":"Yokoi"},{"last_name":"Akazawa","full_name":"Akazawa, Chihiro","first_name":"Chihiro"},{"first_name":"Ryuichi","full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444","last_name":"Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Noboru","full_name":"Mizuno, Noboru","last_name":"Mizuno"},{"last_name":"Masu","first_name":"Masayuki","full_name":"Masu, Masayuki"},{"first_name":"Shigetada","full_name":"Nakanishi, Shigetada","last_name":"Nakanishi"}],"status":"public","type":"journal_article","pmid":1,"scopus_import":"1","intvolume":"       268","title":"Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits","issue":"4","article_processing_charge":"No","oa":1,"date_updated":"2022-03-31T14:29:17Z","publication":"Journal of Biological Chemistry","language":[{"iso":"eng"}],"abstract":[{"text":"cDNA clones for four different N-methyl-D-aspartate (NMDA) receptor subunits (NMDAR2A-NMDAR2D) were isolated through polymerase chain reactions followed by molecular screening of a rat brain cDNA library. These subunits are only about 15% identical with the key subunit of the NMDA receptor (NMDAR1) but are highly homologous (~50% homology) with one another. They also commonly possess large hydrophilic domains at both amino- and carboxyl- terminal sides of the four putative transmembrane segments. NMDAR2A and NMDAR2C expressed individually in Xenopus oocytes showed no electrophysiological response to agonists. However, these subunits in combined expression with NMDAR1 markedly potentiated the NMDAR1 activity and produced functional variability in the affinity of agonists, the effectiveness of antagonists, and the sensitivity to Mg2+ blockade. Thus, NMDAR1 is essential for the function of the NMDA receptor, and multiple NMDAR2 subunits potentiate and differentiate the function of the NMDA receptor by forming different heteromeric configurations with NMDAR1. Northern blotting and in situ hybridization analyses revealed that the expressions of individual mRNAs for the NMDAR2 subunits overlap in some brain regions but are also specialized in many other regions. This investigation demonstrates the anatomical and functional differences of the NMDAR2 subunits, which provide the molecular basis for the functional diversity of the NMDA receptor.","lang":"eng"}],"external_id":{"pmid":["8428958"]},"publication_status":"published","quality_controlled":"1","volume":268,"extern":"1","page":"2836 - 2843","date_published":"1993-02-05T00:00:00Z","publisher":"American Society for Biochemistry and Molecular Biology","date_created":"2018-12-11T11:58:16Z","publist_id":"4360","citation":{"ieee":"T. Ishii <i>et al.</i>, “Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits,” <i>Journal of Biological Chemistry</i>, vol. 268, no. 4. American Society for Biochemistry and Molecular Biology, pp. 2836–2843, 1993.","ama":"Ishii T, Moriyoshi K, Sugihara H, et al. Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits. <i>Journal of Biological Chemistry</i>. 1993;268(4):2836-2843. doi:<a href=\"https://doi.org/10.1016/s0021-9258(18)53849-7 \">10.1016/s0021-9258(18)53849-7 </a>","short":"T. Ishii, K. Moriyoshi, H. Sugihara, K. Sakurada, H. Kadotani, M. Yokoi, C. Akazawa, R. Shigemoto, N. Mizuno, M. Masu, S. Nakanishi, Journal of Biological Chemistry 268 (1993) 2836–2843.","chicago":"Ishii, Takahiro, Koki Moriyoshi, Hidemitsu Sugihara, Kazuhir Sakurada, Hiroshi Kadotani, Mineto Yokoi, Chihiro Akazawa, et al. “Molecular Characterization of the Family of the N-Methyl-D-Aspartate Receptor Subunits.” <i>Journal of Biological Chemistry</i>. American Society for Biochemistry and Molecular Biology, 1993. <a href=\"https://doi.org/10.1016/s0021-9258(18)53849-7 \">https://doi.org/10.1016/s0021-9258(18)53849-7 </a>.","ista":"Ishii T, Moriyoshi K, Sugihara H, Sakurada K, Kadotani H, Yokoi M, Akazawa C, Shigemoto R, Mizuno N, Masu M, Nakanishi S. 1993. Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits. Journal of Biological Chemistry. 268(4), 2836–2843.","mla":"Ishii, Takahiro, et al. “Molecular Characterization of the Family of the N-Methyl-D-Aspartate Receptor Subunits.” <i>Journal of Biological Chemistry</i>, vol. 268, no. 4, American Society for Biochemistry and Molecular Biology, 1993, pp. 2836–43, doi:<a href=\"https://doi.org/10.1016/s0021-9258(18)53849-7 \">10.1016/s0021-9258(18)53849-7 </a>.","apa":"Ishii, T., Moriyoshi, K., Sugihara, H., Sakurada, K., Kadotani, H., Yokoi, M., … Nakanishi, S. (1993). Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits. <i>Journal of Biological Chemistry</i>. American Society for Biochemistry and Molecular Biology. <a href=\"https://doi.org/10.1016/s0021-9258(18)53849-7 \">https://doi.org/10.1016/s0021-9258(18)53849-7 </a>"},"year":"1993","acknowledgement":"This work was supported in part by research grants from the Ministry of Education, Science, and Culture of Japan, the Ministry of Health and Welfare of Japan, the Senri Life Science Foundation, and Yamanouchi Foundation for Research on Metabolic Disorders. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “aduertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.","doi":"10.1016/s0021-9258(18)53849-7 ","article_type":"original","_id":"2539"},{"year":"1993","acknowledgement":"We are grateful for the photographic help of Mr Akira Uesugi and the support of Drs Ryosuke Fujimori, Satoru Fukuchi, Toshio Fukuda, Ritsu Hayashi, Sozaburo Hayashi, Mizuho Katsurada, Yutaka Kitani, Keiko Kumagai, Hiroshi Kuroda, Toshio Kuroda, Hiroshi Matsubara. Hiroshi Matsushima. Chisato Minakuchi. Masatoshi ‘Nishio, Gonpei Niwa, Hajime Oda, Masahiko Ohbayashi, Seiichi Ohbayashi, Hiroyasu Ohtsuka, Shigeo Tamaki, Eizo Watanabe, Kazuo Yoshino and Toshiaki Yoshino. This work was supported in part by Grants-in-Aid from the Ministry of Education, Science and Culture of Japan.","citation":{"chicago":"Ohishi, Hitoshi, Ryuichi Shigemoto, Shigetada Nakanishi, and Noboru Mizuno. “Distribution of the Messenger RNA for a Metabotropic Glutamate Receptor, MGluR2, in the Central Nervous System of the Rat.” <i>Neuroscience</i>. Elsevier, 1993. <a href=\"https://doi.org/10.1016/0306-4522(93)90485-X\">https://doi.org/10.1016/0306-4522(93)90485-X</a>.","mla":"Ohishi, Hitoshi, et al. “Distribution of the Messenger RNA for a Metabotropic Glutamate Receptor, MGluR2, in the Central Nervous System of the Rat.” <i>Neuroscience</i>, vol. 53, no. 4, Elsevier, 1993, pp. 1009–18, doi:<a href=\"https://doi.org/10.1016/0306-4522(93)90485-X\">10.1016/0306-4522(93)90485-X</a>.","ista":"Ohishi H, Shigemoto R, Nakanishi S, Mizuno N. 1993. Distribution of the messenger RNA for a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat. Neuroscience. 53(4), 1009–1018.","ieee":"H. Ohishi, R. Shigemoto, S. Nakanishi, and N. Mizuno, “Distribution of the messenger RNA for a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat,” <i>Neuroscience</i>, vol. 53, no. 4. Elsevier, pp. 1009–1018, 1993.","ama":"Ohishi H, Shigemoto R, Nakanishi S, Mizuno N. Distribution of the messenger RNA for a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat. <i>Neuroscience</i>. 1993;53(4):1009-1018. doi:<a href=\"https://doi.org/10.1016/0306-4522(93)90485-X\">10.1016/0306-4522(93)90485-X</a>","short":"H. Ohishi, R. Shigemoto, S. Nakanishi, N. Mizuno, Neuroscience 53 (1993) 1009–1018.","apa":"Ohishi, H., Shigemoto, R., Nakanishi, S., &#38; Mizuno, N. (1993). Distribution of the messenger RNA for a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat. <i>Neuroscience</i>. Elsevier. <a href=\"https://doi.org/10.1016/0306-4522(93)90485-X\">https://doi.org/10.1016/0306-4522(93)90485-X</a>"},"publist_id":"4358","date_created":"2018-12-11T11:58:16Z","doi":"10.1016/0306-4522(93)90485-X","article_type":"original","_id":"2540","abstract":[{"lang":"eng","text":"Distribution of the messenger RNA for a metabotropic glutamate receptor, mGluR2, which is coupled to the inhibitory cyclic AMP cascade, was investigated in the central nervous system of the adult rat by in situ hybridization. Transcripts of mGluR2 were specifically localized to neuronal cells of the brain. Although the hybridization signals were widely distributed in the brain, the most prominent expression of mGluR2 messenger RNA was seen in Golgi cells of the cerebellum. Marked expression of mGluR2 messenger RNA was further observed in the mitral cells of the accessory olfactory bulb, neurons in the external part of the anterior olfactory nucleus, and pyramidal neurons in the entorhinal and parasubicular cortical regions. The granule cells of the accessory olfactory bulb, and many pyramidal and non-pyramidal neurons in the neocortical, cingulate, retrosplenial and subicular cortices, were moderately labeled. All of the granule cells in the dentate gyrus were also labeled moderately, whereas no significant hybridization signals were detected in Ammon's horn. In the basal forebrain regions, moderately labeled neurons were distributed in the triangular septal nucleus, in the lateral, basolateral and basomedial amygdaloid nuclei, and in the medial mammillary nucleus. Weakly labeled neurons were sparsely scattered in the striatum, globus pallidus, ventral pallidum and claustrum. The subthalamic nucleus was also labeled weakly. No significant labeling was found in the entopeduncular nucleus and substantia nigra. In the thalamus, moderately labeled neurons were distributed in the anterodorsal, anteromedial, ventromedial, intralaminar and midline nuclei; the ventrolateral part of the anteroventral nucleus and the rostral pole of the ventrolateral nucleus also contained moderately labeled neurons. No significant labeling was found in the thalamic reticular, submedius, ventroposterior, lateral geniculate and medial geniculate nuclei. In the lower brainstem, labeling was generally weak. No significant hybridization signals were found in the spinal cord. Some neurons in the inner part of the inner nuclear layer of the retina and some retinal ganglion cells were labeled moderately. The pattern of distribution of mGluR2 messenger RNA revealed in the present study indicates specific roles of mGluR2 in the glutamatergic system in the brain."}],"external_id":{"pmid":["8389425"]},"publication_status":"published","date_published":"1993-01-01T00:00:00Z","publisher":"Elsevier","quality_controlled":"1","volume":53,"extern":"1","page":"1009 - 1018","intvolume":"        53","scopus_import":"1","issue":"4","article_processing_charge":"No","date_updated":"2022-03-31T12:19:44Z","title":"Distribution of the messenger RNA for a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat","publication":"Neuroscience","language":[{"iso":"eng"}],"month":"01","publication_identifier":{"issn":["0306-4522"]},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","oa_version":"None","main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/030645229390485X?via%3Dihub"}],"day":"01","author":[{"last_name":"Ohishi","full_name":"Ohishi, Hitoshi","first_name":"Hitoshi"},{"first_name":"Ryuichi","full_name":"Shigemoto, Ryuichi","last_name":"Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444"},{"last_name":"Nakanishi","first_name":"Shigetada","full_name":"Nakanishi, Shigetada"},{"first_name":"Noboru","full_name":"Mizuno, Noboru","last_name":"Mizuno"}],"type":"journal_article","status":"public","pmid":1},{"extern":"1","page":"157 - 160","volume":153,"quality_controlled":"1","publisher":"Elsevier","date_published":"1993-04-30T00:00:00Z","external_id":{"pmid":["8392153 "]},"abstract":[{"text":"A trp E fusion protein containing a C-terminal portion of the rat substance P receptor (SPR) was expressed in bacteria and used to produce an antibody. The antibody specifically reacted with SPR expressed in a mammalian cell line and rat striatum. Light and electron microscope analyses of the rat striatum revealed intense SPR-like immunoreactivity in neuronal somata and dendrites. These immunoreactive neurons constituted ∼ 3% of the total population of striatal neurons; they were putative interneurons of large and medium-sized aspiny types.","lang":"eng"}],"publication_status":"published","doi":"10.1016/0304-3940(93)90311-8","_id":"2541","article_type":"original","date_created":"2018-12-11T11:58:17Z","publist_id":"4357","citation":{"short":"R. Shigemoto, Y. Nakaya, S. Nomura, R. Ogawa Meguro, H. Ohishi, T. Kaneko, S. Nakanishi, N. Mizuno, Neuroscience Letters 153 (1993) 157–160.","ama":"Shigemoto R, Nakaya Y, Nomura S, et al. Immunocytochemical localization of rat substance P receptor in the striatum. <i>Neuroscience Letters</i>. 1993;153(2):157-160. doi:<a href=\"https://doi.org/10.1016/0304-3940(93)90311-8\">10.1016/0304-3940(93)90311-8</a>","ieee":"R. Shigemoto <i>et al.</i>, “Immunocytochemical localization of rat substance P receptor in the striatum,” <i>Neuroscience Letters</i>, vol. 153, no. 2. Elsevier, pp. 157–160, 1993.","ista":"Shigemoto R, Nakaya Y, Nomura S, Ogawa Meguro R, Ohishi H, Kaneko T, Nakanishi S, Mizuno N. 1993. Immunocytochemical localization of rat substance P receptor in the striatum. Neuroscience Letters. 153(2), 157–160.","chicago":"Shigemoto, Ryuichi, Yoshifumi Nakaya, Sakashi Nomura, Reiko Ogawa Meguro, Hitoshi Ohishi, Takeshi Kaneko, Shigetada Nakanishi, and Noboru Mizuno. “Immunocytochemical Localization of Rat Substance P Receptor in the Striatum.” <i>Neuroscience Letters</i>. Elsevier, 1993. <a href=\"https://doi.org/10.1016/0304-3940(93)90311-8\">https://doi.org/10.1016/0304-3940(93)90311-8</a>.","mla":"Shigemoto, Ryuichi, et al. “Immunocytochemical Localization of Rat Substance P Receptor in the Striatum.” <i>Neuroscience Letters</i>, vol. 153, no. 2, Elsevier, 1993, pp. 157–60, doi:<a href=\"https://doi.org/10.1016/0304-3940(93)90311-8\">10.1016/0304-3940(93)90311-8</a>.","apa":"Shigemoto, R., Nakaya, Y., Nomura, S., Ogawa Meguro, R., Ohishi, H., Kaneko, T., … Mizuno, N. (1993). Immunocytochemical localization of rat substance P receptor in the striatum. <i>Neuroscience Letters</i>. Elsevier. <a href=\"https://doi.org/10.1016/0304-3940(93)90311-8\">https://doi.org/10.1016/0304-3940(93)90311-8</a>"},"year":"1993","pmid":1,"type":"journal_article","status":"public","main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/0304394093903118?via%3Dihub"}],"day":"30","oa_version":"None","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publication_identifier":{"issn":["0304-3940"]},"month":"04","author":[{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi","first_name":"Ryuichi"},{"full_name":"Nakaya, Yoshifumi","first_name":"Yoshifumi","last_name":"Nakaya"},{"last_name":"Nomura","first_name":"Sakashi","full_name":"Nomura, Sakashi"},{"last_name":"Ogawa Meguro","full_name":"Ogawa Meguro, Reiko","first_name":"Reiko"},{"last_name":"Ohishi","full_name":"Ohishi, Hitoshi","first_name":"Hitoshi"},{"first_name":"Takeshi","full_name":"Kaneko, Takeshi","last_name":"Kaneko"},{"full_name":"Nakanishi, Shigetada","first_name":"Shigetada","last_name":"Nakanishi"},{"full_name":"Mizuno, Noboru","first_name":"Noboru","last_name":"Mizuno"}],"publication":"Neuroscience Letters","language":[{"iso":"eng"}],"intvolume":"       153","scopus_import":"1","title":"Immunocytochemical localization of rat substance P receptor in the striatum","date_updated":"2022-03-31T12:10:05Z","issue":"2","article_processing_charge":"No"},{"doi":"10.1016/0304-3940(93)90227-C","_id":"2542","article_type":"original","citation":{"apa":"Shigemoto, R., Nomura, S., Ohishi, H., Sugihara, H., Nakanishi, S., &#38; Mizuno, N. (1993). Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5, in the rat brain. <i>Neuroscience Letters</i>. Elsevier. <a href=\"https://doi.org/10.1016/0304-3940(93)90227-C\">https://doi.org/10.1016/0304-3940(93)90227-C</a>","mla":"Shigemoto, Ryuichi, et al. “Immunohistochemical Localization of a Metabotropic Glutamate Receptor, MGluR5, in the Rat Brain.” <i>Neuroscience Letters</i>, vol. 163, no. 1, Elsevier, 1993, pp. 53–57, doi:<a href=\"https://doi.org/10.1016/0304-3940(93)90227-C\">10.1016/0304-3940(93)90227-C</a>.","ista":"Shigemoto R, Nomura S, Ohishi H, Sugihara H, Nakanishi S, Mizuno N. 1993. Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5, in the rat brain. Neuroscience Letters. 163(1), 53–57.","chicago":"Shigemoto, Ryuichi, Sakashi Nomura, Hitoshi Ohishi, Hidemitsu Sugihara, Shigetada Nakanishi, and Noboru Mizuno. “Immunohistochemical Localization of a Metabotropic Glutamate Receptor, MGluR5, in the Rat Brain.” <i>Neuroscience Letters</i>. Elsevier, 1993. <a href=\"https://doi.org/10.1016/0304-3940(93)90227-C\">https://doi.org/10.1016/0304-3940(93)90227-C</a>.","ieee":"R. Shigemoto, S. Nomura, H. Ohishi, H. Sugihara, S. Nakanishi, and N. Mizuno, “Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5, in the rat brain,” <i>Neuroscience Letters</i>, vol. 163, no. 1. Elsevier, pp. 53–57, 1993.","ama":"Shigemoto R, Nomura S, Ohishi H, Sugihara H, Nakanishi S, Mizuno N. Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5, in the rat brain. <i>Neuroscience Letters</i>. 1993;163(1):53-57. doi:<a href=\"https://doi.org/10.1016/0304-3940(93)90227-C\">10.1016/0304-3940(93)90227-C</a>","short":"R. Shigemoto, S. Nomura, H. Ohishi, H. Sugihara, S. Nakanishi, N. Mizuno, Neuroscience Letters 163 (1993) 53–57."},"publist_id":"4356","date_created":"2018-12-11T11:58:17Z","year":"1993","acknowledgement":"We are grateful to Mr. Akira Uesugi for photographic help","volume":163,"quality_controlled":"1","page":"53 - 57","extern":"1","date_published":"1993-11-26T00:00:00Z","publisher":"Elsevier","abstract":[{"lang":"eng","text":"A trpE-fusion protein containing a C-terminal sequence of a rat metabotropic glutamate receptor, mGluR5, was used to produce an antibody. On immunoblot, the antibody specifically reacted with mGluR5 expressed in mammalian cells and rat brain. Immunohistochemical analysis revealed intense mGluR5-like immunoreactivity (LI) in the olfactory bulb, anterior olfactory nuclei, olfactory tubercle, cerebral cortex, hippocampus, lateral septum, striatum, nucleus accumbens, inferior colliculus, and spinal trigeminal nuclei. The distribution pattern of mGluR5-LI corresponds very well with that of mGluR5 mRNA. Electron microscope analysis of the striatum revealed dense accumulation of immunoreaction products in dendrites which were often provided with asymmetrical synapses. These results suggest that mGluR5 is predominantly located in postsynaptic elements."}],"external_id":{"pmid":["8295733"]},"publication_status":"published","publication":"Neuroscience Letters","language":[{"iso":"eng"}],"scopus_import":"1","intvolume":"       163","title":"Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5, in the rat brain","issue":"1","article_processing_charge":"No","date_updated":"2022-03-31T10:21:52Z","type":"journal_article","status":"public","pmid":1,"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/030439409390227C?via%3Dihub"}],"day":"26","oa_version":"None","month":"11","publication_identifier":{"issn":["0304-3940"]},"author":[{"last_name":"Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi","first_name":"Ryuichi"},{"last_name":"Nomura","first_name":"Sakashi","full_name":"Nomura, Sakashi"},{"full_name":"Ohishi, Hitoshi","first_name":"Hitoshi","last_name":"Ohishi"},{"last_name":"Sugihara","full_name":"Sugihara, Hidemitsu","first_name":"Hidemitsu"},{"full_name":"Nakanishi, Shigetada","first_name":"Shigetada","last_name":"Nakanishi"},{"last_name":"Mizuno","full_name":"Mizuno, Noboru","first_name":"Noboru"}]},{"year":"1993","acknowledgement":"We are grateful to Drs. Y. Sugimoto, A. Ichikawa, J. Ogasawara, R. Fukunaga, H. Aino, and A. Baba for discussion and advice. We also thank Ms. K. Mimura for secretarial assistance. This work was supported in part by the Ministry of Education, Science and Culture of Japan. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 USC Section 1734 solely to indicate this fact.","publist_id":"4355","citation":{"apa":"Hashimoto, H., Ishihara, T., Shigemoto, R., Mori, K., &#38; Nagata, S. (1993).  Molecular cloning and tissue distribution of a receptor for pituitary adenylate cyclase-activating polypeptide. <i>Neuron</i>. Elsevier. <a href=\"https://doi.org/10.1016/0896-6273(93)90188-W\">https://doi.org/10.1016/0896-6273(93)90188-W</a>","ista":"Hashimoto H, Ishihara T, Shigemoto R, Mori K, Nagata S. 1993.  Molecular cloning and tissue distribution of a receptor for pituitary adenylate cyclase-activating polypeptide. Neuron. 11(2), 333–342.","mla":"Hashimoto, Hitoshi, et al. “ Molecular Cloning and Tissue Distribution of a Receptor for Pituitary Adenylate Cyclase-Activating Polypeptide.” <i>Neuron</i>, vol. 11, no. 2, Elsevier, 1993, pp. 333–42, doi:<a href=\"https://doi.org/10.1016/0896-6273(93)90188-W\">10.1016/0896-6273(93)90188-W</a>.","chicago":"Hashimoto, Hitoshi, Takeshi Ishihara, Ryuichi Shigemoto, Kensaku Mori, and Shigekazu Nagata. “ Molecular Cloning and Tissue Distribution of a Receptor for Pituitary Adenylate Cyclase-Activating Polypeptide.” <i>Neuron</i>. Elsevier, 1993. <a href=\"https://doi.org/10.1016/0896-6273(93)90188-W\">https://doi.org/10.1016/0896-6273(93)90188-W</a>.","short":"H. Hashimoto, T. Ishihara, R. Shigemoto, K. Mori, S. Nagata, Neuron 11 (1993) 333–342.","ieee":"H. Hashimoto, T. Ishihara, R. Shigemoto, K. Mori, and S. Nagata, “ Molecular cloning and tissue distribution of a receptor for pituitary adenylate cyclase-activating polypeptide,” <i>Neuron</i>, vol. 11, no. 2. Elsevier, pp. 333–342, 1993.","ama":"Hashimoto H, Ishihara T, Shigemoto R, Mori K, Nagata S.  Molecular cloning and tissue distribution of a receptor for pituitary adenylate cyclase-activating polypeptide. <i>Neuron</i>. 1993;11(2):333-342. doi:<a href=\"https://doi.org/10.1016/0896-6273(93)90188-W\">10.1016/0896-6273(93)90188-W</a>"},"date_created":"2018-12-11T11:58:17Z","doi":"10.1016/0896-6273(93)90188-W","article_type":"original","_id":"2543","abstract":[{"lang":"eng","text":"Pituitary adenylate cyclase-activating polypeptide (PACAP) is a polypeptide hormone related to vasoactive intestinal polypeptide (VIP). Rat PACAP receptor cDNA was isolated from a brain cDNA library by cross-hybridization with rat VIP receptor cDNA. The recombinant PACAP receptor expressed in COS cells bound PACAP with about 1000 times higher affinity than VIP, and PACAP stimulated adenylate cyclase through the cloned PACAP receptor. The rat PACAP receptor consists of 495 amino acids, contains seven transmembrane segments, and has a significant similarity with other Gs-coupled receptors, such as VIP, glucagon, and secretin receptors. PACAP receptor mRNA was abundantly expressed in the brain, but not in the peripheral tissues except for the adrenal gland. In situ hybridization revealed a high level of expression of PACAP receptor mRNA in the hippocampal dentate gyrus, olfactory bulb, and cerebellar cortex."}],"external_id":{"pmid":["8394723"]},"publication_status":"published","date_published":"1993-08-01T00:00:00Z","publisher":"Elsevier","volume":11,"quality_controlled":"1","page":"333 - 342","extern":"1","intvolume":"        11","scopus_import":"1","article_processing_charge":"No","issue":"2","date_updated":"2022-03-31T09:56:46Z","title":" Molecular cloning and tissue distribution of a receptor for pituitary adenylate cyclase-activating polypeptide","publication":"Neuron","language":[{"iso":"eng"}],"publication_identifier":{"issn":["0896-6273"]},"month":"08","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","oa_version":"None","day":"01","main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/089662739390188W?via%3Dihub"}],"author":[{"first_name":"Hitoshi","full_name":"Hashimoto, Hitoshi","last_name":"Hashimoto"},{"last_name":"Ishihara","first_name":"Takeshi","full_name":"Ishihara, Takeshi"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi","first_name":"Ryuichi"},{"full_name":"Mori, Kensaku","first_name":"Kensaku","last_name":"Mori"},{"first_name":"Shigekazu","full_name":"Nagata, Shigekazu","last_name":"Nagata"}],"type":"journal_article","status":"public","pmid":1},{"author":[{"last_name":"Hayashi","first_name":"Yasunori","full_name":"Hayashi, Yasunori"},{"last_name":"Momiyama","first_name":"Akiko","full_name":"Momiyama, Akiko"},{"full_name":"Takahashi, Tomoyuki","first_name":"Tomoyuki","last_name":"Takahashi"},{"last_name":"Ohishi","full_name":"Ohishi, Hitoshi","first_name":"Hitoshi"},{"first_name":"Reiko","full_name":"Ogawa Meguro, Reiko","last_name":"Ogawa Meguro"},{"orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","first_name":"Ryuichi","full_name":"Shigemoto, Ryuichi"},{"first_name":"Noboru","full_name":"Mizuno, Noboru","last_name":"Mizuno"},{"full_name":"Nakanishi, Shigetada","first_name":"Shigetada","last_name":"Nakanishi"}],"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","main_file_link":[{"url":"https://www.nature.com/articles/366687a0"}],"oa_version":"None","day":"01","publication_identifier":{"issn":["0028-0836"]},"month":"01","type":"journal_article","status":"public","pmid":1,"title":"Role of a metabotropic glutamate receptor in synaptic modulation in the accessory olfactory bulb","issue":"6456","article_processing_charge":"No","date_updated":"2022-03-31T09:36:00Z","scopus_import":"1","intvolume":"       366","language":[{"iso":"eng"}],"publication":"Nature","publication_status":"published","abstract":[{"lang":"eng","text":"VARIOUS functions of glutamate transmission are mediated by both ionotropic and metabotropic glutamate receptors1. The metabotropic glutamate receptors (mGluRs) consist of at least six different subtypes that are classified into three subgroups, mGluR1/mGluR5, mGluR2/mGluR3, and mGluR4/mGluR6 (refs 1-5), but their physiological roles are largely unknown. Here we report the identification of a very potent agonist for mGluR2/mGluR3, DCG-IV, and the specific localization of mGluR2 in granule cell dendrites that form dendrodendritic synapses with mitral cells in the accessory olfactory bulb. Using the DCG-IV agonist for mGluR2 in combination with slice patchrecording, we demonstrate that the granule cell mGluR2 presynaptically suppresses inhibitory GABA (γ-aminobutyrate) transmission to the mitral cell. Our results indicate that mGluR2 in granule cells plays an important role in the persistent excitation of olfactory sensory transmission in the accessory olfactory bulb by relieving mitral cells from the GABA inhibition."}],"external_id":{"pmid":["7903116 "]},"volume":366,"quality_controlled":"1","page":"687 - 690","extern":"1","date_published":"1993-01-01T00:00:00Z","publisher":"Nature Publishing Group","date_created":"2018-12-11T11:58:18Z","publist_id":"4354","citation":{"apa":"Hayashi, Y., Momiyama, A., Takahashi, T., Ohishi, H., Ogawa Meguro, R., Shigemoto, R., … Nakanishi, S. (1993). Role of a metabotropic glutamate receptor in synaptic modulation in the accessory olfactory bulb. <i>Nature</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/366687a0\">https://doi.org/10.1038/366687a0</a>","short":"Y. Hayashi, A. Momiyama, T. Takahashi, H. Ohishi, R. Ogawa Meguro, R. Shigemoto, N. Mizuno, S. Nakanishi, Nature 366 (1993) 687–690.","ieee":"Y. Hayashi <i>et al.</i>, “Role of a metabotropic glutamate receptor in synaptic modulation in the accessory olfactory bulb,” <i>Nature</i>, vol. 366, no. 6456. Nature Publishing Group, pp. 687–690, 1993.","ama":"Hayashi Y, Momiyama A, Takahashi T, et al. Role of a metabotropic glutamate receptor in synaptic modulation in the accessory olfactory bulb. <i>Nature</i>. 1993;366(6456):687-690. doi:<a href=\"https://doi.org/10.1038/366687a0\">10.1038/366687a0</a>","chicago":"Hayashi, Yasunori, Akiko Momiyama, Tomoyuki Takahashi, Hitoshi Ohishi, Reiko Ogawa Meguro, Ryuichi Shigemoto, Noboru Mizuno, and Shigetada Nakanishi. “Role of a Metabotropic Glutamate Receptor in Synaptic Modulation in the Accessory Olfactory Bulb.” <i>Nature</i>. Nature Publishing Group, 1993. <a href=\"https://doi.org/10.1038/366687a0\">https://doi.org/10.1038/366687a0</a>.","mla":"Hayashi, Yasunori, et al. “Role of a Metabotropic Glutamate Receptor in Synaptic Modulation in the Accessory Olfactory Bulb.” <i>Nature</i>, vol. 366, no. 6456, Nature Publishing Group, 1993, pp. 687–90, doi:<a href=\"https://doi.org/10.1038/366687a0\">10.1038/366687a0</a>.","ista":"Hayashi Y, Momiyama A, Takahashi T, Ohishi H, Ogawa Meguro R, Shigemoto R, Mizuno N, Nakanishi S. 1993. Role of a metabotropic glutamate receptor in synaptic modulation in the accessory olfactory bulb. Nature. 366(6456), 687–690."},"year":"1993","acknowledgement":"We thank Y. Ohfune and K. Shimamoto for DCG-IV, M. Kuno for advice and A. Uesugi for photographic assistance. Partly supported by research grants from the Ministry of Education, Science and Culture of Japan, the Ministry of Health and Welfare of Japan and the Senri Life Science Foundation. ","_id":"2544","article_type":"original","doi":"10.1038/366687a0"},{"date_published":"1993-12-24T00:00:00Z","publisher":"Elsevier","volume":631,"quality_controlled":"1","page":"297 - 303","extern":"1","abstract":[{"text":"Immunochemical characteristics of neostriatal neurons producing substance P receptor (SPR) were examined in adult rats by double- and triple-immunofluorescence methods. In the neostriatum, SPR immunoreactivity was detected in large and medium-sized aspiny neurons. Virtually all SPR-immunoreactive neurons in the neostriatum contained somatostatin (SS) or choline acetyltransferase (ChAT), but not parvalbumin. All SS- and ChAT-immunoreactive neurons in the neostriatum showed SPR immunoreactivity. The co-existence of SS and ChAT was, however, not found in single neurons expressing SPR immunoreactivity. The present results indicate that neostriatal neurons immunoreactive for SPR are segregated into 2 groups: (1) medium-sized, aspiny somatostatinergic, and (2) large, aspiny cholinergic neurons.","lang":"eng"}],"external_id":{"pmid":["7907524"]},"publication_status":"published","doi":"10.1016/0006-8993(93)91548-7","article_type":"original","_id":"2546","year":"1993","citation":{"chicago":"Kaneko, Takeshi, Ryuichi Shigemoto, Shigetada Nakanishi, and Noboru Mizuno. “Substance P Receptor-Immunoreactive Neurons in the Rat Neostriatum Are Segregated into Somatostatinergic and Cholinergic Aspiny Neurons.” <i>Brain Research</i>. Elsevier, 1993. <a href=\"https://doi.org/10.1016/0006-8993(93)91548-7\">https://doi.org/10.1016/0006-8993(93)91548-7</a>.","mla":"Kaneko, Takeshi, et al. “Substance P Receptor-Immunoreactive Neurons in the Rat Neostriatum Are Segregated into Somatostatinergic and Cholinergic Aspiny Neurons.” <i>Brain Research</i>, vol. 631, no. 2, Elsevier, 1993, pp. 297–303, doi:<a href=\"https://doi.org/10.1016/0006-8993(93)91548-7\">10.1016/0006-8993(93)91548-7</a>.","ista":"Kaneko T, Shigemoto R, Nakanishi S, Mizuno N. 1993. Substance P receptor-immunoreactive neurons in the rat neostriatum are segregated into somatostatinergic and cholinergic aspiny neurons. Brain Research. 631(2), 297–303.","short":"T. Kaneko, R. Shigemoto, S. Nakanishi, N. Mizuno, Brain Research 631 (1993) 297–303.","ama":"Kaneko T, Shigemoto R, Nakanishi S, Mizuno N. Substance P receptor-immunoreactive neurons in the rat neostriatum are segregated into somatostatinergic and cholinergic aspiny neurons. <i>Brain Research</i>. 1993;631(2):297-303. doi:<a href=\"https://doi.org/10.1016/0006-8993(93)91548-7\">10.1016/0006-8993(93)91548-7</a>","ieee":"T. Kaneko, R. Shigemoto, S. Nakanishi, and N. Mizuno, “Substance P receptor-immunoreactive neurons in the rat neostriatum are segregated into somatostatinergic and cholinergic aspiny neurons,” <i>Brain Research</i>, vol. 631, no. 2. Elsevier, pp. 297–303, 1993.","apa":"Kaneko, T., Shigemoto, R., Nakanishi, S., &#38; Mizuno, N. (1993). Substance P receptor-immunoreactive neurons in the rat neostriatum are segregated into somatostatinergic and cholinergic aspiny neurons. <i>Brain Research</i>. Elsevier. <a href=\"https://doi.org/10.1016/0006-8993(93)91548-7\">https://doi.org/10.1016/0006-8993(93)91548-7</a>"},"date_created":"2018-12-11T11:58:18Z","publist_id":"4353","type":"journal_article","status":"public","pmid":1,"month":"12","publication_identifier":{"issn":["0006-8993"]},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","oa_version":"None","day":"24","main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/0006899393915487?via%3Dihub"}],"author":[{"last_name":"Kaneko","full_name":"Kaneko, Takeshi","first_name":"Takeshi"},{"orcid":"0000-0001-8761-9444","last_name":"Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","full_name":"Shigemoto, Ryuichi"},{"last_name":"Nakanishi","first_name":"Shigetada","full_name":"Nakanishi, Shigetada"},{"first_name":"Noboru","full_name":"Mizuno, Noboru","last_name":"Mizuno"}],"publication":"Brain Research","language":[{"iso":"eng"}],"intvolume":"       631","scopus_import":"1","issue":"2","article_processing_charge":"No","date_updated":"2022-03-31T09:14:23Z","title":"Substance P receptor-immunoreactive neurons in the rat neostriatum are segregated into somatostatinergic and cholinergic aspiny neurons"},{"publication":"Letters in Mathematical Physics","language":[{"iso":"eng"}],"scopus_import":"1","intvolume":"        29","title":"Ground-state density of the Pauli operator in the large field limit","date_updated":"2022-03-30T15:02:00Z","issue":"3","article_processing_charge":"No","type":"journal_article","status":"public","day":"01","main_file_link":[{"url":"https://link.springer.com/article/10.1007/BF00761110"}],"oa_version":"None","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","month":"11","publication_identifier":{"issn":["0377-9017"]},"author":[{"first_name":"László","full_name":"Erdös, László","last_name":"Erdös","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5366-9603"}],"doi":"10.1007/BF00761110","article_type":"original","_id":"2723","publist_id":"4169","date_created":"2018-12-11T11:59:16Z","citation":{"ista":"Erdös L. 1993. Ground-state density of the Pauli operator in the large field limit. Letters in Mathematical Physics. 29(3), 219–240.","mla":"Erdös, László. “Ground-State Density of the Pauli Operator in the Large Field Limit.” <i>Letters in Mathematical Physics</i>, vol. 29, no. 3, Springer, 1993, pp. 219–40, doi:<a href=\"https://doi.org/10.1007/BF00761110\">10.1007/BF00761110</a>.","chicago":"Erdös, László. “Ground-State Density of the Pauli Operator in the Large Field Limit.” <i>Letters in Mathematical Physics</i>. Springer, 1993. <a href=\"https://doi.org/10.1007/BF00761110\">https://doi.org/10.1007/BF00761110</a>.","ama":"Erdös L. Ground-state density of the Pauli operator in the large field limit. <i>Letters in Mathematical Physics</i>. 1993;29(3):219-240. doi:<a href=\"https://doi.org/10.1007/BF00761110\">10.1007/BF00761110</a>","ieee":"L. Erdös, “Ground-state density of the Pauli operator in the large field limit,” <i>Letters in Mathematical Physics</i>, vol. 29, no. 3. Springer, pp. 219–240, 1993.","short":"L. Erdös, Letters in Mathematical Physics 29 (1993) 219–240.","apa":"Erdös, L. (1993). Ground-state density of the Pauli operator in the large field limit. <i>Letters in Mathematical Physics</i>. Springer. <a href=\"https://doi.org/10.1007/BF00761110\">https://doi.org/10.1007/BF00761110</a>"},"year":"1993","extern":"1","page":"219 - 240","volume":29,"quality_controlled":"1","publisher":"Springer","date_published":"1993-11-01T00:00:00Z","abstract":[{"text":"The ground-state density of the Pauli operator in the case of a nonconstant magnetic field with constant direction is studied. It is shown that in the large field limit, the naturally rescaled ground-state density function is bounded from above by the megnetic field, and under some additional conditions, the limit density function is equal to the magnetic field. A restatement of this result yields an estimate on the density of complex orthogonal polynomials with respect to a fairly general weight function. We also prove a special case of the paramagnetic inequality. ","lang":"eng"}],"publication_status":"published"},{"_id":"3446","article_type":"original","doi":"10.1109/82.222823","date_created":"2018-12-11T12:03:22Z","publist_id":"2941","citation":{"apa":"Sziranyi, T., &#38; Csicsvari, J. L. (1993). High-speed character recognition using a dual cellular neural network architecture (CNND). <i>IEEE Transactions on Circuits and Systems II: Analog and Digital Signal Processing</i>. IEEE. <a href=\"https://doi.org/10.1109/82.222823\">https://doi.org/10.1109/82.222823</a>","chicago":"Sziranyi, Tamas, and Jozsef L Csicsvari. “High-Speed Character Recognition Using a Dual Cellular Neural Network Architecture (CNND).” <i>IEEE Transactions on Circuits and Systems II: Analog and Digital Signal Processing</i>. IEEE, 1993. <a href=\"https://doi.org/10.1109/82.222823\">https://doi.org/10.1109/82.222823</a>.","ista":"Sziranyi T, Csicsvari JL. 1993. High-speed character recognition using a dual cellular neural network architecture (CNND). IEEE Transactions on Circuits and Systems II: Analog and Digital Signal Processing. 40(3), 223–231.","mla":"Sziranyi, Tamas, and Jozsef L. Csicsvari. “High-Speed Character Recognition Using a Dual Cellular Neural Network Architecture (CNND).” <i>IEEE Transactions on Circuits and Systems II: Analog and Digital Signal Processing</i>, vol. 40, no. 3, IEEE, 1993, pp. 223–31, doi:<a href=\"https://doi.org/10.1109/82.222823\">10.1109/82.222823</a>.","short":"T. Sziranyi, J.L. Csicsvari, IEEE Transactions on Circuits and Systems II: Analog and Digital Signal Processing 40 (1993) 223–231.","ieee":"T. Sziranyi and J. L. Csicsvari, “High-speed character recognition using a dual cellular neural network architecture (CNND),” <i>IEEE Transactions on Circuits and Systems II: Analog and Digital Signal Processing</i>, vol. 40, no. 3. IEEE, pp. 223–231, 1993.","ama":"Sziranyi T, Csicsvari JL. High-speed character recognition using a dual cellular neural network architecture (CNND). <i>IEEE Transactions on Circuits and Systems II: Analog and Digital Signal Processing</i>. 1993;40(3):223-231. doi:<a href=\"https://doi.org/10.1109/82.222823\">10.1109/82.222823</a>"},"year":"1993","volume":40,"quality_controlled":"1","page":"223 - 231","extern":"1","date_published":"1993-03-01T00:00:00Z","publisher":"IEEE","publication_status":"published","abstract":[{"text":"An effective character recognition procedure implemented on a new type of hardware system and using a new architecture called CNND is proposed. This CNND contains one or more analog cellular neural networks (CNNs) and some digital logic, combining the advantages of the fast analog CNN signal processing and the fast and easy decision capability of digital logic. It is shown that the CNND system can be used for recognition of multifont printed or handwritten characters and could recognize 100,000 char/s with a recognition rate of more than 95%. The more advantage of the system over competing types is that there is not an extra feature extraction procedure implemented in slow hardware","lang":"eng"}],"language":[{"iso":"eng"}],"publication":"IEEE Transactions on Circuits and Systems II: Analog and Digital Signal Processing","title":"High-speed character recognition using a dual cellular neural network architecture (CNND)","issue":"3","article_processing_charge":"No","date_updated":"2022-03-30T14:44:44Z","scopus_import":"1","intvolume":"        40","status":"public","type":"journal_article","author":[{"first_name":"Tamas","full_name":"Sziranyi, Tamas","last_name":"Sziranyi"},{"orcid":"0000-0002-5193-4036","last_name":"Csicsvari","id":"3FA14672-F248-11E8-B48F-1D18A9856A87","first_name":"Jozsef L","full_name":"Csicsvari, Jozsef L"}],"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","main_file_link":[{"url":"https://ieeexplore.ieee.org/document/222823"}],"oa_version":"None","day":"01","month":"03","publication_identifier":{"issn":["1057-7130"]}},{"date_published":"1993-12-20T00:00:00Z","publisher":"New York Academy of Sciences","quality_controlled":"1","volume":707,"extern":"1","page":"126 - 135","publication_status":"published","series_title":"Annals of the New York Academy of Sciences","external_id":{"pmid":["9729204"]},"_id":"3451","doi":"10.1111/j.1749-6632.1993.tb38048.x","year":"1993","acknowledgement":"I thank Prof. B. Sakmann for generous support and Drs. M. Häusser and A. Villarroel for critically reading the manuscript.","date_created":"2018-12-11T12:03:24Z","publist_id":"2936","citation":{"apa":"Jonas, P. M. (1993). Glutamate receptors in the central nervous system. In <i>Molecular Basis of Ion Channels and Receptors Involved in Nerve Excitation, Synaptic Transmission, and Muscle Contraction</i> (Vol. 707, pp. 126–135). New York Academy of Sciences. <a href=\"https://doi.org/10.1111/j.1749-6632.1993.tb38048.x\">https://doi.org/10.1111/j.1749-6632.1993.tb38048.x</a>","mla":"Jonas, Peter M. “Glutamate Receptors in the Central Nervous System.” <i>Molecular Basis of Ion Channels and Receptors Involved in Nerve Excitation, Synaptic Transmission, and Muscle Contraction</i>, vol. 707, New York Academy of Sciences, 1993, pp. 126–35, doi:<a href=\"https://doi.org/10.1111/j.1749-6632.1993.tb38048.x\">10.1111/j.1749-6632.1993.tb38048.x</a>.","chicago":"Jonas, Peter M. “Glutamate Receptors in the Central Nervous System.” In <i>Molecular Basis of Ion Channels and Receptors Involved in Nerve Excitation, Synaptic Transmission, and Muscle Contraction</i>, 707:126–35. Annals of the New York Academy of Sciences. New York Academy of Sciences, 1993. <a href=\"https://doi.org/10.1111/j.1749-6632.1993.tb38048.x\">https://doi.org/10.1111/j.1749-6632.1993.tb38048.x</a>.","ista":"Jonas PM. 1993.Glutamate receptors in the central nervous system. In: Molecular Basis of Ion Channels and Receptors Involved in Nerve Excitation, Synaptic Transmission, and Muscle Contraction. Annals of the New York Academy of Sciences , vol. 707, 126–135.","short":"P.M. Jonas, in:, Molecular Basis of Ion Channels and Receptors Involved in Nerve Excitation, Synaptic Transmission, and Muscle Contraction, New York Academy of Sciences, 1993, pp. 126–135.","ieee":"P. M. Jonas, “Glutamate receptors in the central nervous system,” in <i>Molecular Basis of Ion Channels and Receptors Involved in Nerve Excitation, Synaptic Transmission, and Muscle Contraction</i>, vol. 707, New York Academy of Sciences, 1993, pp. 126–135.","ama":"Jonas PM. Glutamate receptors in the central nervous system. In: <i>Molecular Basis of Ion Channels and Receptors Involved in Nerve Excitation, Synaptic Transmission, and Muscle Contraction</i>. Vol 707. Annals of the New York Academy of Sciences. New York Academy of Sciences; 1993:126-135. doi:<a href=\"https://doi.org/10.1111/j.1749-6632.1993.tb38048.x\">10.1111/j.1749-6632.1993.tb38048.x</a>"},"status":"public","type":"book_chapter","pmid":1,"alternative_title":["Annals of the New York Academy of Sciences "],"author":[{"full_name":"Jonas, Peter M","first_name":"Peter M","orcid":"0000-0001-5001-4804","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","last_name":"Jonas"}],"month":"12","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","day":"20","main_file_link":[{"url":"https://nyaspubs.onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.1993.tb38048.x"}],"oa_version":"None","language":[{"iso":"eng"}],"publication":"Molecular Basis of Ion Channels and Receptors Involved in Nerve Excitation, Synaptic Transmission, and Muscle Contraction","article_processing_charge":"No","date_updated":"2022-03-30T12:35:23Z","title":"Glutamate receptors in the central nervous system","intvolume":"       707","scopus_import":"1"},{"date_published":"1993-01-01T00:00:00Z","publisher":"Birkhäuser","quality_controlled":"1","volume":66,"extern":"1","page":"61 - 76","abstract":[{"text":"In recent years, considerable progress in our understanding of the molecular events underlying excitatory synaptic transmission has been made. This progress was mainly achieved by technical advances, among them the patch-clamp technique in brain slices (Edwards et al., 1989), fast application of agonists (Franke et al., 1987), and cloning and functional expression of GluR channels of the nonNMDA type (e.g., Hollmann et al., 1989). A suitable model for studying excitatory postsynaptic currents (EPSCs) in the brain slice with patch-clamp techniques is the mossy fiber synapse on CA3 pyramidal cells of rat hippocampus (MF-CA3 synapse). This synapse is located close to the cell soma and should provide almost ideal space-clamp conditions. A comparison of MF-CA3 EPSCs with the currents activated by fast application of glutamate on membrane patches isolated from CA3 cell somata suggests that the concentration of glutamate in the synaptic cleft during excitatory synaptic transmission is high (about 1 mM) and that the transmitter remains in the synaptic cleft only briefly (about 1 ms). It seems likely that desensitization influences the peak amplitude of the EPSC in several ways. Brief pulses of glutamate cause desensitization, from which the glutamate receptor channels recover only slowly, and micromolar ambient glutamate concentrations produce desensitization at equilibrium. From the functional properties of recombinant GluR channels, in situ hybridization data, and patch-clamp experiments on different neuronal and nonneuronal cell types, a picture of the molecular identity of native channels emerges. In neurons of the hippocampus the pharmacological features of these channels were similar to recombinant channels assembled from subunits of the AMPA/kainate subtype which are strongly expressed in these cells. The native channels are characterized by outward rectification of the steady-state I-V and low Ca permeability, similar to recombinant channels containing the GluR-B subunit. This is consistent with the ubiquitous expression of this subunit in hippocampal neurones. In contrast, GluR channels from cerebellar glial cells, which uniquely in the central nervous system lack the expression of GluR-B subunits, show double rectification and high Ca permeability. The results suggest that the native functional nonNMDA glutamate receptor channels in the CNS are assembled form subunits of the AMPA/kainate subtype in a cell-specific way, with the functional properties of GluR channels in neurones being dominated by the GluR-B subunit.","lang":"eng"}],"external_id":{"pmid":["7505664"]},"publication_status":"published","doi":"10.1007/978-3-0348-7327-7_4","_id":"3452","year":"1993","citation":{"chicago":"Jonas, Peter M. “AMPA-Type Glutamate Receptors - Nonselective Cation Channels Mediating Fast Excitatory Transmission in the CNS.” In <i>Nonselective Cation Channels: Pharmacology, Physiology and Biophysics.</i>, edited by Detlef Siemen, 66:61–76. Birkhäuser, 1993. <a href=\"https://doi.org/10.1007/978-3-0348-7327-7_4\">https://doi.org/10.1007/978-3-0348-7327-7_4</a>.","mla":"Jonas, Peter M. “AMPA-Type Glutamate Receptors - Nonselective Cation Channels Mediating Fast Excitatory Transmission in the CNS.” <i>Nonselective Cation Channels: Pharmacology, Physiology and Biophysics.</i>, edited by Detlef Siemen, vol. 66, Birkhäuser, 1993, pp. 61–76, doi:<a href=\"https://doi.org/10.1007/978-3-0348-7327-7_4\">10.1007/978-3-0348-7327-7_4</a>.","ista":"Jonas PM. 1993.AMPA-type glutamate receptors - nonselective cation channels mediating fast excitatory transmission in the CNS. In: Nonselective cation channels: Pharmacology, Physiology and Biophysics. EXS, vol. 66, 61–76.","ieee":"P. M. Jonas, “AMPA-type glutamate receptors - nonselective cation channels mediating fast excitatory transmission in the CNS,” in <i>Nonselective cation channels: Pharmacology, Physiology and Biophysics.</i>, vol. 66, D. Siemen, Ed. Birkhäuser, 1993, pp. 61–76.","ama":"Jonas PM. AMPA-type glutamate receptors - nonselective cation channels mediating fast excitatory transmission in the CNS. In: Siemen D, ed. <i>Nonselective Cation Channels: Pharmacology, Physiology and Biophysics.</i> Vol 66. Birkhäuser; 1993:61-76. doi:<a href=\"https://doi.org/10.1007/978-3-0348-7327-7_4\">10.1007/978-3-0348-7327-7_4</a>","short":"P.M. Jonas, in:, D. Siemen (Ed.), Nonselective Cation Channels: Pharmacology, Physiology and Biophysics., Birkhäuser, 1993, pp. 61–76.","apa":"Jonas, P. M. (1993). AMPA-type glutamate receptors - nonselective cation channels mediating fast excitatory transmission in the CNS. In D. Siemen (Ed.), <i>Nonselective cation channels: Pharmacology, Physiology and Biophysics.</i> (Vol. 66, pp. 61–76). Birkhäuser. <a href=\"https://doi.org/10.1007/978-3-0348-7327-7_4\">https://doi.org/10.1007/978-3-0348-7327-7_4</a>"},"date_created":"2018-12-11T12:03:24Z","publist_id":"2935","status":"public","type":"book_chapter","alternative_title":["EXS"],"pmid":1,"publication_identifier":{"isbn":["978-3-0348-7327-7"]},"month":"01","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","main_file_link":[{"url":"https://link.springer.com/chapter/10.1007/978-3-0348-7327-7_4"}],"day":"01","oa_version":"None","author":[{"first_name":"Peter M","full_name":"Jonas, Peter M","last_name":"Jonas","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5001-4804"}],"publication":"Nonselective cation channels: Pharmacology, Physiology and Biophysics.","language":[{"iso":"eng"}],"editor":[{"first_name":"Detlef","full_name":"Siemen, Detlef","last_name":"Siemen"}],"intvolume":"        66","scopus_import":"1","article_processing_charge":"No","date_updated":"2022-03-30T11:46:44Z","title":"AMPA-type glutamate receptors - nonselective cation channels mediating fast excitatory transmission in the CNS"},{"date_created":"2018-12-11T12:03:31Z","publist_id":"2914","citation":{"ama":"Ruppersberg P, Ermler M, Knopf M, Kues W, Jonas PM, Koenen M. Properties of Shaker-homologous potassium channels expressed in the mammalian brain. <i>Cellular Physiology and Biochemistry</i>. 1993;3:250-269. doi:<a href=\"https://doi.org/10.1159/000154691\">10.1159/000154691</a>","ieee":"P. Ruppersberg, M. Ermler, M. Knopf, W. Kues, P. M. Jonas, and M. Koenen, “Properties of Shaker-homologous potassium channels expressed in the mammalian brain.,” <i>Cellular Physiology and Biochemistry</i>, vol. 3. S. Karger AG, pp. 250–269, 1993.","short":"P. Ruppersberg, M. Ermler, M. Knopf, W. Kues, P.M. Jonas, M. Koenen, Cellular Physiology and Biochemistry 3 (1993) 250–269.","ista":"Ruppersberg P, Ermler M, Knopf M, Kues W, Jonas PM, Koenen M. 1993. Properties of Shaker-homologous potassium channels expressed in the mammalian brain. Cellular Physiology and Biochemistry. 3, 250–269.","mla":"Ruppersberg, Peter, et al. “Properties of Shaker-Homologous Potassium Channels Expressed in the Mammalian Brain.” <i>Cellular Physiology and Biochemistry</i>, vol. 3, S. Karger AG, 1993, pp. 250–69, doi:<a href=\"https://doi.org/10.1159/000154691\">10.1159/000154691</a>.","chicago":"Ruppersberg, Peter, Mamfred Ermler, Martin Knopf, Wilfried Kues, Peter M Jonas, and Michael Koenen. “Properties of Shaker-Homologous Potassium Channels Expressed in the Mammalian Brain.” <i>Cellular Physiology and Biochemistry</i>. S. Karger AG, 1993. <a href=\"https://doi.org/10.1159/000154691\">https://doi.org/10.1159/000154691</a>.","apa":"Ruppersberg, P., Ermler, M., Knopf, M., Kues, W., Jonas, P. M., &#38; Koenen, M. (1993). Properties of Shaker-homologous potassium channels expressed in the mammalian brain. <i>Cellular Physiology and Biochemistry</i>. S. Karger AG. <a href=\"https://doi.org/10.1159/000154691\">https://doi.org/10.1159/000154691</a>"},"year":"1993","doi":"10.1159/000154691","article_type":"original","_id":"3473","abstract":[{"text":"Sixteen different K+ channel subtypes have been cloned from mammalian tissue. Considering their sequence homology to Drosophila Shaker, Shab, Shaw and Shal channels, they were classified into four corresponding classes Kv1-4. All K+ channels belonging to these classes consist of four subunits with each six hydrophobic segments (S1-S6) and a characteristic structure-function relationship of certain domains in their amino acid sequence. These domains are, the inactivation gate in the N-terminal region of the sequence, the voltage sensor in the fourth hydrophobic segment (S4), and the pore-region in the H5 segment between S5 and S6. In some functional properties K+ channels cloned from the mammalian brain, however, differ from Drosophila K+ channels. These are pharmacological differences, differences in the threshold of activation and in regulation of inactivation. Part of these differences are important to understand their physiological role in the brain. Based on their functional characteristics the expression pattern of cloned K+ channels in the rat brain can be correlated with the properties of K+ currents measured in central neurones.","lang":"eng"}],"publication_status":"published","extern":"1","page":"250 - 269","volume":3,"quality_controlled":"1","publisher":"S. Karger AG","date_published":"1993-01-01T00:00:00Z","scopus_import":"1","intvolume":"         3","title":"Properties of Shaker-homologous potassium channels expressed in the mammalian brain.","date_updated":"2022-03-30T10:21:04Z","article_processing_charge":"No","publication":"Cellular Physiology and Biochemistry","language":[{"iso":"eng"}],"oa_version":"None","day":"01","main_file_link":[{"url":"https://www.karger.com/Article/Abstract/154691"}],"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publication_identifier":{"issn":["1015-8987"]},"month":"01","author":[{"last_name":"Ruppersberg","full_name":"Ruppersberg, Peter","first_name":"Peter"},{"last_name":"Ermler","full_name":"Ermler, Mamfred","first_name":"Mamfred"},{"last_name":"Knopf","first_name":"Martin","full_name":"Knopf, Martin"},{"last_name":"Kues","first_name":"Wilfried","full_name":"Kues, Wilfried"},{"orcid":"0000-0001-5001-4804","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","last_name":"Jonas","full_name":"Jonas, Peter M","first_name":"Peter M"},{"full_name":"Koenen, Michael","first_name":"Michael","last_name":"Koenen"}],"status":"public","type":"journal_article"},{"article_type":"original","_id":"3474","doi":"10.1113/jphysiol.1993.sp019965","citation":{"apa":"Jonas, P. M., Major, G., &#38; Sakmann, B. (1993). Quantal components of unitary EPSCs at the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus. <i>Journal of Physiology</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1113/jphysiol.1993.sp019965\">https://doi.org/10.1113/jphysiol.1993.sp019965</a>","short":"P.M. Jonas, G. Major, B. Sakmann, Journal of Physiology 472 (1993) 615–663.","ieee":"P. M. Jonas, G. Major, and B. Sakmann, “Quantal components of unitary EPSCs at the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus,” <i>Journal of Physiology</i>, vol. 472. Wiley-Blackwell, pp. 615–663, 1993.","ama":"Jonas PM, Major G, Sakmann B. Quantal components of unitary EPSCs at the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus. <i>Journal of Physiology</i>. 1993;472:615-663. doi:<a href=\"https://doi.org/10.1113/jphysiol.1993.sp019965\">10.1113/jphysiol.1993.sp019965</a>","mla":"Jonas, Peter M., et al. “Quantal Components of Unitary EPSCs at the Mossy Fibre Synapse on CA3 Pyramidal Cells of Rat Hippocampus.” <i>Journal of Physiology</i>, vol. 472, Wiley-Blackwell, 1993, pp. 615–63, doi:<a href=\"https://doi.org/10.1113/jphysiol.1993.sp019965\">10.1113/jphysiol.1993.sp019965</a>.","ista":"Jonas PM, Major G, Sakmann B. 1993. Quantal components of unitary EPSCs at the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus. Journal of Physiology. 472, 615–663.","chicago":"Jonas, Peter M, Guy Major, and Bert Sakmann. “Quantal Components of Unitary EPSCs at the Mossy Fibre Synapse on CA3 Pyramidal Cells of Rat Hippocampus.” <i>Journal of Physiology</i>. Wiley-Blackwell, 1993. <a href=\"https://doi.org/10.1113/jphysiol.1993.sp019965\">https://doi.org/10.1113/jphysiol.1993.sp019965</a>."},"publist_id":"2913","date_created":"2018-12-11T12:03:31Z","acknowledgement":"We are indebted to Professor B. Katz for critically reading the manuscript and for helpful suggestions. We especially thank Professor D. Colquhoun for several discussions, for generously providing the source codes of programs for maximum-likelihood fit with sums of Gaussian functions, a routine for calculating the error function and for critically reading the manuscript. We also thank Drs A. Larkman, P. Ruppersberg, N. Spuston and G. Stuart for critically reading the manuscript, P. Andersen, B. Betz, J. Evans, K. Harris, E. v. Kitzing, R. Rahamimov and K. Stratford for helpful discussions, and J. J. B. Jack for much-needed advice and guidance to G.M. We thank K. Bauer, F. Helmchen, M. Huke, B. Manz and especially A. Roth for computer programming, B. Werner for typing the manuscript, and M. Kaiser for excellent technical assistance. Part of the project was supported by the Deutsche Forschungsgemeinschaft (SFB-317)\r\nand the Wellcome Trust.","year":"1993","page":"615 - 663","extern":"1","quality_controlled":"1","volume":472,"publisher":"Wiley-Blackwell","date_published":"1993-12-01T00:00:00Z","publication_status":"published","external_id":{"pmid":["7908327"]},"abstract":[{"lang":"eng","text":"1. Excitatory postsynaptic currents (EPSCs) were recorded in CA3 pyramidal cells of hippocampal slices of 15- to 24-day-old rats (22 degrees C) using the whole-cell configuration of the patch clamp technique. 2. Composite EPSCs were evoked by extracellular stimulation of the mossy fibre tract. Using the selective blockers 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and D-2-amino-5-phosphonopentanoic acid (APV), a major alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA)/kainate receptor-mediated component and a minor NMDA receptor-mediated component with slower time course were distinguished. For the AMPA/kainate receptor-mediated component, the peak current-voltage (I-V) relation was linear, with a reversal potential close to 0 mV. The half-maximal blocking concentration of CNQX was 353 nM. 3. Unitary EPSCs of the mossy fibre terminal (MF)-CA3 pyramidal cell synapse were evoked at membrane potentials of -70 to -90 mV by low-intensity extracellular stimulation of granule cell somata using fine-tipped pipettes. The EPSC peak amplitude as a function of stimulus intensity showed all-or-none behaviour. The region of low threshold was restricted to a few micrometres. This suggests that extracellular stimulation was focal, and that the stimulus-evoked EPSCs were unitary. 4. Latency and rise time histograms of EPSCs evoked by granule cell stimulation showed narrow unimodal distributions within each experiment. The mean latency was 4.2 +/- 1.0 ms, and the mean 20-80% rise time was 0.6 +/- 0.1 ms (23 cells). When fitted within the range 0.7 ms to 20 ms after the peak, the decay of the EPSCs with the fastest rise (rise time 0.5 ms or less) could be described by a single exponential function; the mean time constant was in the range 3.0-6.6 ms with a mean of 4.8 ms (8 cells). 5. Peak amplitudes of the EPSCs evoked by suprathreshold granule cell stimulation fluctuated between trials. The apparent EPSC peak conductance in normal extracellular solution (2 mM Ca2+, 1 mM Mg2+), excluding failures, was 1 nS. Reducing the Ca2+ concentration and increasing the Mg2+ concentration reduced the mean peak amplitude in a concentration-dependent manner. 6. Peaks in EPSC peak amplitude distributions were apparent in low Ca2+ and high Mg2+. Using the criteria of equidistance and the presence of peaks and dips in the autocorrelation function, five of nine EPSC peak amplitude distributions were judged to be quantal."}],"language":[{"iso":"eng"}],"publication":"Journal of Physiology","title":"Quantal components of unitary EPSCs at the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus","oa":1,"date_updated":"2022-03-30T09:33:19Z","article_processing_charge":"No","scopus_import":"1","intvolume":"       472","pmid":1,"status":"public","type":"journal_article","author":[{"full_name":"Jonas, Peter M","first_name":"Peter M","last_name":"Jonas","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5001-4804"},{"last_name":"Major","full_name":"Major, Guy","first_name":"Guy"},{"first_name":"Bert","full_name":"Sakmann, Bert","last_name":"Sakmann"}],"main_file_link":[{"url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1160505","open_access":"1"}],"oa_version":"Published Version","day":"01","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","month":"12","publication_identifier":{"issn":["0022-3751"]}}]