@unpublished{14644,
  abstract     = {Transcription by RNA polymerase II (Pol II) can be repressed by noncoding RNA, including the human RNA Alu. However, the mechanism by which endogenous RNAs repress transcription remains unclear. Here we present cryo-electron microscopy structures of Pol II bound to Alu RNA, which reveal that Alu RNA mimics how DNA and RNA bind to Pol II during transcription elongation. Further, we show how domains of the general transcription factor TFIIF affect complex dynamics and control repressive activity. Together, we reveal how a non-coding RNA can regulate mammalian gene expression.},
  author       = {Tluckova, Katarina and Testa Salmazo, Anita P and Bernecky, Carrie A},
  publisher    = {Institute of Science and Technology Austria},
  title        = {{Mechanism of mammalian transcriptional repression by noncoding RNA}},
  doi          = {10.15479/AT:ISTA:14644},
  year         = {2023},
}