---
_id: '14039'
abstract:
- lang: eng
  text: Membranes are essential for life. They act as semi-permeable boundaries that
    define cells and organelles. In addition, their surfaces actively participate
    in biochemical reaction networks, where they confine proteins, align reaction
    partners, and directly control enzymatic activities. Membrane-localized reactions
    shape cellular membranes, define the identity of organelles, compartmentalize
    biochemical processes, and can even be the source of signaling gradients that
    originate at the plasma membrane and reach into the cytoplasm and nucleus. The
    membrane surface is, therefore, an essential platform upon which myriad cellular
    processes are scaffolded. In this review, we summarize our current understanding
    of the biophysics and biochemistry of membrane-localized reactions with particular
    focus on insights derived from reconstituted and cellular systems. We discuss
    how the interplay of cellular factors results in their self-organization, condensation,
    assembly, and activity, and the emergent properties derived from them.
acknowledgement: We acknowledge funding from the Austrian Science Fund (FWF F79, P32814-B,
  and P35061-B to S.M.; P34607-B to M.L.; and P30584-B and P33066-B to T.A.L.) and
  the European Research Council (ERC) under the European Union’s Horizon 2020 research
  and innovation program (grant agreement no. 101045340 to M.L.). We are grateful
  for comments on the manuscript by Justyna Sawa-Makarska, Verena Baumann, Marko Kojic,
  Philipp Radler, Ronja Reinhardt, and Sumire Antonioli.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Thomas A.
  full_name: Leonard, Thomas A.
  last_name: Leonard
- first_name: Martin
  full_name: Loose, Martin
  id: 462D4284-F248-11E8-B48F-1D18A9856A87
  last_name: Loose
  orcid: 0000-0001-7309-9724
- first_name: Sascha
  full_name: Martens, Sascha
  last_name: Martens
citation:
  ama: Leonard TA, Loose M, Martens S. The membrane surface as a platform that organizes
    cellular and biochemical processes. <i>Developmental Cell</i>. 2023;58(15):1315-1332.
    doi:<a href="https://doi.org/10.1016/j.devcel.2023.06.001">10.1016/j.devcel.2023.06.001</a>
  apa: Leonard, T. A., Loose, M., &#38; Martens, S. (2023). The membrane surface as
    a platform that organizes cellular and biochemical processes. <i>Developmental
    Cell</i>. Elsevier. <a href="https://doi.org/10.1016/j.devcel.2023.06.001">https://doi.org/10.1016/j.devcel.2023.06.001</a>
  chicago: Leonard, Thomas A., Martin Loose, and Sascha Martens. “The Membrane Surface
    as a Platform That Organizes Cellular and Biochemical Processes.” <i>Developmental
    Cell</i>. Elsevier, 2023. <a href="https://doi.org/10.1016/j.devcel.2023.06.001">https://doi.org/10.1016/j.devcel.2023.06.001</a>.
  ieee: T. A. Leonard, M. Loose, and S. Martens, “The membrane surface as a platform
    that organizes cellular and biochemical processes,” <i>Developmental Cell</i>,
    vol. 58, no. 15. Elsevier, pp. 1315–1332, 2023.
  ista: Leonard TA, Loose M, Martens S. 2023. The membrane surface as a platform that
    organizes cellular and biochemical processes. Developmental Cell. 58(15), 1315–1332.
  mla: Leonard, Thomas A., et al. “The Membrane Surface as a Platform That Organizes
    Cellular and Biochemical Processes.” <i>Developmental Cell</i>, vol. 58, no. 15,
    Elsevier, 2023, pp. 1315–32, doi:<a href="https://doi.org/10.1016/j.devcel.2023.06.001">10.1016/j.devcel.2023.06.001</a>.
  short: T.A. Leonard, M. Loose, S. Martens, Developmental Cell 58 (2023) 1315–1332.
date_created: 2023-08-13T22:01:12Z
date_published: 2023-08-07T00:00:00Z
date_updated: 2023-12-13T12:09:20Z
day: '07'
ddc:
- '570'
department:
- _id: MaLo
doi: 10.1016/j.devcel.2023.06.001
external_id:
  isi:
  - '001059110400001'
  pmid:
  - '37419118'
file:
- access_level: open_access
  checksum: d8c5dc97cd40c26da2ec98ae723ab368
  content_type: application/pdf
  creator: dernst
  date_created: 2023-08-14T07:57:55Z
  date_updated: 2023-08-14T07:57:55Z
  file_id: '14049'
  file_name: 2023_DevelopmentalCell_Leonard.pdf
  file_size: 3184217
  relation: main_file
  success: 1
file_date_updated: 2023-08-14T07:57:55Z
has_accepted_license: '1'
intvolume: '        58'
isi: 1
issue: '15'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: 1315-1332
pmid: 1
project:
- _id: fc38323b-9c52-11eb-aca3-ff8afb4a011d
  grant_number: P34607
  name: "Understanding bacterial cell division by in vitro\r\nreconstitution"
- _id: bd6ae2ca-d553-11ed-ba76-a4aa239da5ee
  grant_number: '101045340'
  name: Synthetic and structural biology of Rab GTPase networks
publication: Developmental Cell
publication_identifier:
  eissn:
  - 1878-1551
  issn:
  - 1534-5807
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: The membrane surface as a platform that organizes cellular and biochemical
  processes
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 58
year: '2023'
...