---
_id: '12702'
abstract:
- lang: eng
  text: Hydrocarbon mixtures are extremely abundant in the Universe, and diamond formation
    from them can play a crucial role in shaping the interior structure and evolution
    of planets. With first-principles accuracy, we first estimate the melting line
    of diamond, and then reveal the nature of chemical bonding in hydrocarbons at
    extreme conditions. We finally establish the pressure-temperature phase boundary
    where it is thermodynamically possible for diamond to form from hydrocarbon mixtures
    with different atomic fractions of carbon. Notably, here we show a depletion zone
    at pressures above 200 GPa and temperatures below 3000 K-3500 K where diamond
    formation is thermodynamically favorable regardless of the carbon atomic fraction,
    due to a phase separation mechanism. The cooler condition of the interior of Neptune
    compared to Uranus means that the former is much more likely to contain the depletion
    zone. Our findings can help explain the dichotomy of the two ice giants manifested
    by the low luminosity of Uranus, and lead to a better understanding of (exo-)planetary
    formation and evolution.
acknowledgement: BC thanks Daan Frenkel for stimulating discussions. We thank Aleks
  Reinhardt, Daan Frenkel, Marius Millot, Federica Coppari, Rhys Bunting, and Chris
  J. Pickard for critically reading the manuscript and providing useful suggestions.
  BC acknowledges resources provided by the Cambridge Tier-2 system operated by the
  University of Cambridge Research Computing Service funded by EPSRC Tier-2 capital
  grant EP/P020259/1. SH acknowledges support from LDRD 19-ERD-031 and computing support
  from the Lawrence Livermore National Laboratory (LLNL) Institutional Computing Grand
  Challenge program. Lawrence Livermore National Laboratory is operated by Lawrence
  Livermore National Security, LLC, for the U.S. Department of Energy, National Nuclear
  Security Administration under Contract DE-AC52-07NA27344. MB acknowledges support
  by the European Horizon 2020 program within the Marie Skłodowska-Curie actions (xICE
  grant number 894725), funding from the NOMIS foundation and computational resources
  at the North-German Supercomputing Alliance (HLRN) facilities.
article_number: '1104'
article_processing_charge: No
article_type: original
author:
- first_name: Bingqing
  full_name: Cheng, Bingqing
  id: cbe3cda4-d82c-11eb-8dc7-8ff94289fcc9
  last_name: Cheng
  orcid: 0000-0002-3584-9632
- first_name: Sebastien
  full_name: Hamel, Sebastien
  last_name: Hamel
- first_name: Mandy
  full_name: Bethkenhagen, Mandy
  id: 201939f4-803f-11ed-ab7e-d8da4bd1517f
  last_name: Bethkenhagen
  orcid: 0000-0002-1838-2129
citation:
  ama: Cheng B, Hamel S, Bethkenhagen M. Thermodynamics of diamond formation from
    hydrocarbon mixtures in planets. <i>Nature Communications</i>. 2023;14. doi:<a
    href="https://doi.org/10.1038/s41467-023-36841-1">10.1038/s41467-023-36841-1</a>
  apa: Cheng, B., Hamel, S., &#38; Bethkenhagen, M. (2023). Thermodynamics of diamond
    formation from hydrocarbon mixtures in planets. <i>Nature Communications</i>.
    Springer Nature. <a href="https://doi.org/10.1038/s41467-023-36841-1">https://doi.org/10.1038/s41467-023-36841-1</a>
  chicago: Cheng, Bingqing, Sebastien Hamel, and Mandy Bethkenhagen. “Thermodynamics
    of Diamond Formation from Hydrocarbon Mixtures in Planets.” <i>Nature Communications</i>.
    Springer Nature, 2023. <a href="https://doi.org/10.1038/s41467-023-36841-1">https://doi.org/10.1038/s41467-023-36841-1</a>.
  ieee: B. Cheng, S. Hamel, and M. Bethkenhagen, “Thermodynamics of diamond formation
    from hydrocarbon mixtures in planets,” <i>Nature Communications</i>, vol. 14.
    Springer Nature, 2023.
  ista: Cheng B, Hamel S, Bethkenhagen M. 2023. Thermodynamics of diamond formation
    from hydrocarbon mixtures in planets. Nature Communications. 14, 1104.
  mla: Cheng, Bingqing, et al. “Thermodynamics of Diamond Formation from Hydrocarbon
    Mixtures in Planets.” <i>Nature Communications</i>, vol. 14, 1104, Springer Nature,
    2023, doi:<a href="https://doi.org/10.1038/s41467-023-36841-1">10.1038/s41467-023-36841-1</a>.
  short: B. Cheng, S. Hamel, M. Bethkenhagen, Nature Communications 14 (2023).
date_created: 2023-03-05T23:01:04Z
date_published: 2023-02-27T00:00:00Z
date_updated: 2023-08-01T13:36:11Z
day: '27'
ddc:
- '540'
department:
- _id: BiCh
doi: 10.1038/s41467-023-36841-1
external_id:
  isi:
  - '000939678300002'
  pmid:
  - '36843123'
file:
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  checksum: 5ff61ad21511950c15abb73b18613883
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  creator: cchlebak
  date_created: 2023-03-07T10:58:00Z
  date_updated: 2023-03-07T10:58:00Z
  file_id: '12713'
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  file_size: 1946443
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language:
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month: '02'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 9B861AAC-BA93-11EA-9121-9846C619BF3A
  name: NOMIS Fellowship Program
publication: Nature Communications
publication_identifier:
  eissn:
  - 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Thermodynamics of diamond formation from hydrocarbon mixtures in planets
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 14
year: '2023'
...
---
_id: '11143'
abstract:
- lang: eng
  text: 'Dravet syndrome is a neurodevelopmental disorder characterized by epilepsy,
    intellectual disability, and sudden death due to pathogenic variants in SCN1A
    with loss of function of the sodium channel subunit Nav1.1. Nav1.1-expressing
    parvalbumin GABAergic interneurons (PV-INs) from young Scn1a+/− mice show impaired
    action potential generation. An approach assessing PV-IN function in the same
    mice at two time points shows impaired spike generation in all Scn1a+/− mice at
    postnatal days (P) 16–21, whether deceased prior or surviving to P35, with normalization
    by P35 in surviving mice. However, PV-IN synaptic transmission is dysfunctional
    in young Scn1a+/− mice that did not survive and in Scn1a+/− mice ≥ P35. Modeling
    confirms that PV-IN axonal propagation is more sensitive to decreased sodium conductance
    than spike generation. These results demonstrate dynamic dysfunction in Dravet
    syndrome: combined abnormalities of PV-IN spike generation and propagation drives
    early disease severity, while ongoing dysfunction of synaptic transmission contributes
    to chronic pathology.'
acknowledgement: We would like to thank Bernardo Rudy, Joanna Mattis, and Laura Mcgarry
  for comments on a previous version of the manuscript; Xiaohong Zhang for expert
  technical support and mouse colony maintenance; Melody Cheng for assistance with
  generation of the graphical abstract; and Jennifer Kearney for the gift of Scn1a+/−
  mice. This work was supported by the National Institute of Neurological Disorders
  and Stroke of the National Institutes of Health under F31NS111803 (to K.M.G.) and
  K08NS097633 and R01NS110869 (to E.M.G.), the Dravet Syndrome Foundation (to A.S.),
  an ERC Consolidator Grant (SYNAPSEEK) (to T.P.V.), and the NOMIS Foundation through
  the NOMIS Fellowships program at IST Austria (to C.C.). The graphical abstract was
  prepared using BioRender software (BioRender.com).
article_number: '110580'
article_processing_charge: No
article_type: original
author:
- first_name: Keisuke
  full_name: Kaneko, Keisuke
  last_name: Kaneko
- first_name: Christopher
  full_name: Currin, Christopher
  id: e8321fc5-3091-11eb-8a53-83f309a11ac9
  last_name: Currin
  orcid: 0000-0002-4809-5059
- first_name: Kevin M.
  full_name: Goff, Kevin M.
  last_name: Goff
- first_name: Eric R.
  full_name: Wengert, Eric R.
  last_name: Wengert
- first_name: Ala
  full_name: Somarowthu, Ala
  last_name: Somarowthu
- first_name: Tim P
  full_name: Vogels, Tim P
  id: CB6FF8D2-008F-11EA-8E08-2637E6697425
  last_name: Vogels
  orcid: 0000-0003-3295-6181
- first_name: Ethan M.
  full_name: Goldberg, Ethan M.
  last_name: Goldberg
citation:
  ama: Kaneko K, Currin C, Goff KM, et al. Developmentally regulated impairment of
    parvalbumin interneuron synaptic transmission in an experimental model of Dravet
    syndrome. <i>Cell Reports</i>. 2022;38(13). doi:<a href="https://doi.org/10.1016/j.celrep.2022.110580">10.1016/j.celrep.2022.110580</a>
  apa: Kaneko, K., Currin, C., Goff, K. M., Wengert, E. R., Somarowthu, A., Vogels,
    T. P., &#38; Goldberg, E. M. (2022). Developmentally regulated impairment of parvalbumin
    interneuron synaptic transmission in an experimental model of Dravet syndrome.
    <i>Cell Reports</i>. Elsevier. <a href="https://doi.org/10.1016/j.celrep.2022.110580">https://doi.org/10.1016/j.celrep.2022.110580</a>
  chicago: Kaneko, Keisuke, Christopher Currin, Kevin M. Goff, Eric R. Wengert, Ala
    Somarowthu, Tim P Vogels, and Ethan M. Goldberg. “Developmentally Regulated Impairment
    of Parvalbumin Interneuron Synaptic Transmission in an Experimental Model of Dravet
    Syndrome.” <i>Cell Reports</i>. Elsevier, 2022. <a href="https://doi.org/10.1016/j.celrep.2022.110580">https://doi.org/10.1016/j.celrep.2022.110580</a>.
  ieee: K. Kaneko <i>et al.</i>, “Developmentally regulated impairment of parvalbumin
    interneuron synaptic transmission in an experimental model of Dravet syndrome,”
    <i>Cell Reports</i>, vol. 38, no. 13. Elsevier, 2022.
  ista: Kaneko K, Currin C, Goff KM, Wengert ER, Somarowthu A, Vogels TP, Goldberg
    EM. 2022. Developmentally regulated impairment of parvalbumin interneuron synaptic
    transmission in an experimental model of Dravet syndrome. Cell Reports. 38(13),
    110580.
  mla: Kaneko, Keisuke, et al. “Developmentally Regulated Impairment of Parvalbumin
    Interneuron Synaptic Transmission in an Experimental Model of Dravet Syndrome.”
    <i>Cell Reports</i>, vol. 38, no. 13, 110580, Elsevier, 2022, doi:<a href="https://doi.org/10.1016/j.celrep.2022.110580">10.1016/j.celrep.2022.110580</a>.
  short: K. Kaneko, C. Currin, K.M. Goff, E.R. Wengert, A. Somarowthu, T.P. Vogels,
    E.M. Goldberg, Cell Reports 38 (2022).
date_created: 2022-04-10T22:01:39Z
date_published: 2022-03-29T00:00:00Z
date_updated: 2023-08-03T06:32:55Z
day: '29'
ddc:
- '570'
department:
- _id: TiVo
doi: 10.1016/j.celrep.2022.110580
ec_funded: 1
external_id:
  isi:
  - '000779794000001'
file:
- access_level: open_access
  checksum: 49105c6c27c9af0f37f50a8bbb4d380d
  content_type: application/pdf
  creator: dernst
  date_created: 2022-04-15T11:00:58Z
  date_updated: 2022-04-15T11:00:58Z
  file_id: '11172'
  file_name: 2022_CellReports_Kaneko.pdf
  file_size: 4774216
  relation: main_file
  success: 1
file_date_updated: 2022-04-15T11:00:58Z
has_accepted_license: '1'
intvolume: '        38'
isi: 1
issue: '13'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
project:
- _id: 0aacfa84-070f-11eb-9043-d7eb2c709234
  call_identifier: H2020
  grant_number: '819603'
  name: Learning the shape of synaptic plasticity rules for neuronal architectures
    and function through machine learning.
- _id: 9B861AAC-BA93-11EA-9121-9846C619BF3A
  name: NOMIS Fellowship Program
publication: Cell Reports
publication_identifier:
  eissn:
  - 2211-1247
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Developmentally regulated impairment of parvalbumin interneuron synaptic transmission
  in an experimental model of Dravet syndrome
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 38
year: '2022'
...
---
_id: '10530'
abstract:
- lang: eng
  text: "Cell dispersion from a confined area is fundamental in a number of biological
    processes,\r\nincluding cancer metastasis. To date, a quantitative understanding
    of the interplay of single\r\ncell motility, cell proliferation, and intercellular
    contacts remains elusive. In particular, the role\r\nof E- and N-Cadherin junctions,
    central components of intercellular contacts, is still\r\ncontroversial. Combining
    theoretical modeling with in vitro observations, we investigate the\r\ncollective
    spreading behavior of colonies of human cancer cells (T24). The spreading of these\r\ncolonies
    is driven by stochastic single-cell migration with frequent transient cell-cell
    contacts.\r\nWe find that inhibition of E- and N-Cadherin junctions decreases
    colony spreading and average\r\nspreading velocities, without affecting the strength
    of correlations in spreading velocities of\r\nneighboring cells. Based on a biophysical
    simulation model for cell migration, we show that the\r\nbehavioral changes upon
    disruption of these junctions can be explained by reduced repulsive\r\nexcluded
    volume interactions between cells. This suggests that in cancer cell migration,\r\ncadherin-based
    intercellular contacts sharpen cell boundaries leading to repulsive rather than\r\ncohesive
    interactions between cells, thereby promoting efficient cell spreading during
    collective\r\nmigration.\r\n"
acknowledgement: Funded by the Deutsche Forschungsgemeinschaft (DFG, German Research
  Foundation) - Project-ID 201269156 - SFB 1032 (Projects B8 and B12). D.B.B. is supported
  in part by a DFG fellowship within the Graduate School of Quantitative Biosciences
  Munich (QBM) and by the Joachim Herz Stiftung.
article_processing_charge: No
article_type: original
author:
- first_name: Themistoklis
  full_name: Zisis, Themistoklis
  last_name: Zisis
- first_name: David
  full_name: Brückner, David
  id: e1e86031-6537-11eb-953a-f7ab92be508d
  last_name: Brückner
  orcid: 0000-0001-7205-2975
- first_name: Tom
  full_name: Brandstätter, Tom
  last_name: Brandstätter
- first_name: Wei Xiong
  full_name: Siow, Wei Xiong
  last_name: Siow
- first_name: Joseph
  full_name: d’Alessandro, Joseph
  last_name: d’Alessandro
- first_name: Angelika M.
  full_name: Vollmar, Angelika M.
  last_name: Vollmar
- first_name: Chase P.
  full_name: Broedersz, Chase P.
  last_name: Broedersz
- first_name: Stefan
  full_name: Zahler, Stefan
  last_name: Zahler
citation:
  ama: Zisis T, Brückner D, Brandstätter T, et al. Disentangling cadherin-mediated
    cell-cell interactions in collective cancer cell migration. <i>Biophysical Journal</i>.
    2022;121(1):P44-60. doi:<a href="https://doi.org/10.1016/j.bpj.2021.12.006">10.1016/j.bpj.2021.12.006</a>
  apa: Zisis, T., Brückner, D., Brandstätter, T., Siow, W. X., d’Alessandro, J., Vollmar,
    A. M., … Zahler, S. (2022). Disentangling cadherin-mediated cell-cell interactions
    in collective cancer cell migration. <i>Biophysical Journal</i>. Elsevier. <a
    href="https://doi.org/10.1016/j.bpj.2021.12.006">https://doi.org/10.1016/j.bpj.2021.12.006</a>
  chicago: Zisis, Themistoklis, David Brückner, Tom Brandstätter, Wei Xiong Siow,
    Joseph d’Alessandro, Angelika M. Vollmar, Chase P. Broedersz, and Stefan Zahler.
    “Disentangling Cadherin-Mediated Cell-Cell Interactions in Collective Cancer Cell
    Migration.” <i>Biophysical Journal</i>. Elsevier, 2022. <a href="https://doi.org/10.1016/j.bpj.2021.12.006">https://doi.org/10.1016/j.bpj.2021.12.006</a>.
  ieee: T. Zisis <i>et al.</i>, “Disentangling cadherin-mediated cell-cell interactions
    in collective cancer cell migration,” <i>Biophysical Journal</i>, vol. 121, no.
    1. Elsevier, pp. P44-60, 2022.
  ista: Zisis T, Brückner D, Brandstätter T, Siow WX, d’Alessandro J, Vollmar AM,
    Broedersz CP, Zahler S. 2022. Disentangling cadherin-mediated cell-cell interactions
    in collective cancer cell migration. Biophysical Journal. 121(1), P44-60.
  mla: Zisis, Themistoklis, et al. “Disentangling Cadherin-Mediated Cell-Cell Interactions
    in Collective Cancer Cell Migration.” <i>Biophysical Journal</i>, vol. 121, no.
    1, Elsevier, 2022, pp. P44-60, doi:<a href="https://doi.org/10.1016/j.bpj.2021.12.006">10.1016/j.bpj.2021.12.006</a>.
  short: T. Zisis, D. Brückner, T. Brandstätter, W.X. Siow, J. d’Alessandro, A.M.
    Vollmar, C.P. Broedersz, S. Zahler, Biophysical Journal 121 (2022) P44-60.
date_created: 2021-12-10T09:48:19Z
date_published: 2022-01-04T00:00:00Z
date_updated: 2023-08-02T13:34:25Z
day: '04'
ddc:
- '570'
department:
- _id: EdHa
- _id: GaTk
doi: 10.1016/j.bpj.2021.12.006
external_id:
  isi:
  - '000740815400007'
file:
- access_level: open_access
  checksum: 1aa7c3478e0c8256b973b632efd1f6b4
  content_type: application/pdf
  creator: dernst
  date_created: 2022-07-29T10:17:10Z
  date_updated: 2022-07-29T10:17:10Z
  file_id: '11697'
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  file_size: 4475504
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  success: 1
file_date_updated: 2022-07-29T10:17:10Z
has_accepted_license: '1'
intvolume: '       121'
isi: 1
issue: '1'
keyword:
- Biophysics
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
page: P44-60
project:
- _id: 9B861AAC-BA93-11EA-9121-9846C619BF3A
  name: NOMIS Fellowship Program
publication: Biophysical Journal
publication_identifier:
  issn:
  - 0006-3495
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: Disentangling cadherin-mediated cell-cell interactions in collective cancer
  cell migration
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 121
year: '2022'
...