---
_id: '13266'
abstract:
- lang: eng
  text: The 3′,5′-cyclic adenosine monophosphate (cAMP) is a versatile second messenger
    in many mammalian signaling pathways. However, its role in plants remains not
    well-recognized. Recent discovery of adenylate cyclase (AC) activity for transport
    inhibitor response 1/auxin-signaling F-box proteins (TIR1/AFB) auxin receptors
    and the demonstration of its importance for canonical auxin signaling put plant
    cAMP research back into spotlight. This insight briefly summarizes the well-established
    cAMP signaling pathways in mammalian cells and describes the turbulent and controversial
    history of plant cAMP research highlighting the major progress and the unresolved
    points. We also briefly review the current paradigm of auxin signaling to provide
    a background for the discussion on the AC activity of TIR1/AFB auxin receptors
    and its potential role in transcriptional auxin signaling as well as impact of
    these discoveries on plant cAMP research in general.
acknowledgement: 'We gratefully acknowledge our brave colleagues, whose excellent
  efforts kept the plant cAMP research going in the last two decades. The authors
  were financially supported by the Austrian Science Fund (FWF): I 6123 and P 37051-B.'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Linlin
  full_name: Qi, Linlin
  id: 44B04502-A9ED-11E9-B6FC-583AE6697425
  last_name: Qi
  orcid: 0000-0001-5187-8401
- first_name: Jiří
  full_name: Friml, Jiří
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
citation:
  ama: Qi L, Friml J. Tale of cAMP as a second messenger in auxin signaling and beyond.
    <i>New Phytologist</i>. 2023;240(2):489-495. doi:<a href="https://doi.org/10.1111/nph.19123">10.1111/nph.19123</a>
  apa: Qi, L., &#38; Friml, J. (2023). Tale of cAMP as a second messenger in auxin
    signaling and beyond. <i>New Phytologist</i>. Wiley. <a href="https://doi.org/10.1111/nph.19123">https://doi.org/10.1111/nph.19123</a>
  chicago: Qi, Linlin, and Jiří Friml. “Tale of CAMP as a Second Messenger in Auxin
    Signaling and Beyond.” <i>New Phytologist</i>. Wiley, 2023. <a href="https://doi.org/10.1111/nph.19123">https://doi.org/10.1111/nph.19123</a>.
  ieee: L. Qi and J. Friml, “Tale of cAMP as a second messenger in auxin signaling
    and beyond,” <i>New Phytologist</i>, vol. 240, no. 2. Wiley, pp. 489–495, 2023.
  ista: Qi L, Friml J. 2023. Tale of cAMP as a second messenger in auxin signaling
    and beyond. New Phytologist. 240(2), 489–495.
  mla: Qi, Linlin, and Jiří Friml. “Tale of CAMP as a Second Messenger in Auxin Signaling
    and Beyond.” <i>New Phytologist</i>, vol. 240, no. 2, Wiley, 2023, pp. 489–95,
    doi:<a href="https://doi.org/10.1111/nph.19123">10.1111/nph.19123</a>.
  short: L. Qi, J. Friml, New Phytologist 240 (2023) 489–495.
date_created: 2023-07-23T22:01:13Z
date_published: 2023-10-01T00:00:00Z
date_updated: 2024-01-29T11:21:55Z
day: '01'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1111/nph.19123
external_id:
  isi:
  - '001026321500001'
  pmid:
  - '37434303'
file:
- access_level: open_access
  checksum: 6d9bbd45b8e7bb3ceee2586d447bacb2
  content_type: application/pdf
  creator: dernst
  date_created: 2024-01-29T11:21:43Z
  date_updated: 2024-01-29T11:21:43Z
  file_id: '14898'
  file_name: 2023_NewPhytologist_Qi.pdf
  file_size: 974464
  relation: main_file
  success: 1
file_date_updated: 2024-01-29T11:21:43Z
has_accepted_license: '1'
intvolume: '       240'
isi: 1
issue: '2'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
page: 489-495
pmid: 1
project:
- _id: bd76d395-d553-11ed-ba76-f678c14f9033
  grant_number: I06123
  name: Peptide receptor complexes for auxin canalization and regeneration in Arabidopsis
- _id: 7bcece63-9f16-11ee-852c-ae94e099eeb6
  grant_number: P37051
  name: Guanylate cyclase activity of TIR1/AFBs auxin receptors
publication: New Phytologist
publication_identifier:
  eissn:
  - 1469-8137
  issn:
  - 0028-646X
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Tale of cAMP as a second messenger in auxin signaling and beyond
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 240
year: '2023'
...