---
_id: '14732'
abstract:
- lang: eng
  text: 'Fragmented landscapes pose a significant threat to the persistence of species
    as they are highly susceptible to heightened risk of extinction due to the combined
    effects of genetic and demographic factors such as genetic drift and demographic
    stochasticity. This paper explores the intricate interplay between genetic load
    and extinction risk within metapopulations with a focus on understanding the impact
    of eco-evolutionary feedback mechanisms. We distinguish between two models of
    selection: soft selection, characterised by subpopulations maintaining carrying
    capacity despite load, and hard selection, where load can significantly affect
    population size. Within the soft selection framework, we investigate the impact
    of gene flow on genetic load at a single locus, while also considering the effect
    of selection strength and dominance coefficient. We subsequently build on this
    to examine how gene flow influences both population size and load under hard selection
    as well as identify critical thresholds for metapopulation persistence. Our analysis
    employs the diffusion, semi-deterministic and effective migration approximations.
    Our findings reveal that under soft selection, even modest levels of migration
    can significantly alleviate the burden of load. In sharp contrast, with hard selection,
    a much higher degree of gene flow is required to mitigate load and prevent the
    collapse of the metapopulation. Overall, this study sheds light into the crucial
    role migration plays in shaping the dynamics of genetic load and extinction risk
    in fragmented landscapes, offering valuable insights for conservation strategies
    and the preservation of diversity in a changing world.'
article_processing_charge: No
author:
- first_name: Oluwafunmilola O
  full_name: Olusanya, Oluwafunmilola O
  id: 41AD96DC-F248-11E8-B48F-1D18A9856A87
  last_name: Olusanya
  orcid: 0000-0003-1971-8314
- first_name: Kseniia
  full_name: Khudiakova, Kseniia
  id: 4E6DC800-AE37-11E9-AC72-31CAE5697425
  last_name: Khudiakova
  orcid: 0000-0002-6246-1465
- first_name: Himani
  full_name: Sachdeva, Himani
  id: 42377A0A-F248-11E8-B48F-1D18A9856A87
  last_name: Sachdeva
citation:
  ama: Olusanya OO, Khudiakova K, Sachdeva H. Genetic load, eco-evolutionary feedback
    and extinction in a metapopulation. <i>bioRxiv</i>. doi:<a href="https://doi.org/10.1101/2023.12.02.569702">10.1101/2023.12.02.569702</a>
  apa: Olusanya, O. O., Khudiakova, K., &#38; Sachdeva, H. (n.d.). Genetic load, eco-evolutionary
    feedback and extinction in a metapopulation. <i>bioRxiv</i>. <a href="https://doi.org/10.1101/2023.12.02.569702">https://doi.org/10.1101/2023.12.02.569702</a>
  chicago: Olusanya, Oluwafunmilola O, Kseniia Khudiakova, and Himani Sachdeva. “Genetic
    Load, Eco-Evolutionary Feedback and Extinction in a Metapopulation.” <i>BioRxiv</i>,
    n.d. <a href="https://doi.org/10.1101/2023.12.02.569702">https://doi.org/10.1101/2023.12.02.569702</a>.
  ieee: O. O. Olusanya, K. Khudiakova, and H. Sachdeva, “Genetic load, eco-evolutionary
    feedback and extinction in a metapopulation,” <i>bioRxiv</i>. .
  ista: Olusanya OO, Khudiakova K, Sachdeva H. Genetic load, eco-evolutionary feedback
    and extinction in a metapopulation. bioRxiv, <a href="https://doi.org/10.1101/2023.12.02.569702">10.1101/2023.12.02.569702</a>.
  mla: Olusanya, Oluwafunmilola O., et al. “Genetic Load, Eco-Evolutionary Feedback
    and Extinction in a Metapopulation.” <i>BioRxiv</i>, doi:<a href="https://doi.org/10.1101/2023.12.02.569702">10.1101/2023.12.02.569702</a>.
  short: O.O. Olusanya, K. Khudiakova, H. Sachdeva, BioRxiv (n.d.).
date_created: 2024-01-04T09:35:54Z
date_published: 2023-12-04T00:00:00Z
date_updated: 2025-05-26T09:05:10Z
day: '04'
department:
- _id: NiBa
- _id: JaMa
doi: 10.1101/2023.12.02.569702
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
main_file_link:
- open_access: '1'
  url: https://www.biorxiv.org/content/10.1101/2023.12.02.569702v1
month: '12'
oa: 1
oa_version: Preprint
project:
- _id: c08d3278-5a5b-11eb-8a69-fdb09b55f4b8
  grant_number: P32896
  name: Causes and consequences of population fragmentation
- _id: 34d33d68-11ca-11ed-8bc3-ec13763c0ca8
  grant_number: '26293'
  name: The impact of deleterious mutations on small populations
- _id: 34c872fe-11ca-11ed-8bc3-8534b82131e6
  grant_number: '26380'
  name: Polygenic Adaptation in a Metapopulation
publication: bioRxiv
publication_status: submitted
related_material:
  record:
  - id: '14711'
    relation: dissertation_contains
    status: public
status: public
title: Genetic load, eco-evolutionary feedback and extinction in a metapopulation
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: preprint
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...