[{"file_date_updated":"2021-06-08T10:04:10Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"volume":184,"publication_status":"published","oa":1,"file":[{"content_type":"application/pdf","relation":"main_file","file_id":"9534","success":1,"date_created":"2021-06-08T10:04:10Z","file_name":"2021_Cell_Petridou.pdf","file_size":11405875,"creator":"cziletti","date_updated":"2021-06-08T10:04:10Z","access_level":"open_access","checksum":"1e5295fbd9c2a459173ec45a0e8a7c2e"}],"abstract":[{"lang":"eng","text":"Embryo morphogenesis is impacted by dynamic changes in tissue material properties, which have been proposed to occur via processes akin to phase transitions (PTs). Here, we show that rigidity percolation provides a simple and robust theoretical framework to predict material/structural PTs of embryonic tissues from local cell connectivity. By using percolation theory, combined with directly monitoring dynamic changes in tissue rheology and cell contact mechanics, we demonstrate that the zebrafish blastoderm undergoes a genuine rigidity PT, brought about by a small reduction in adhesion-dependent cell connectivity below a critical value. We quantitatively predict and experimentally verify hallmarks of PTs, including power-law exponents and associated discontinuities of macroscopic observables. Finally, we show that this uniform PT depends on blastoderm cells undergoing meta-synchronous divisions causing random and, consequently, uniform changes in cell connectivity. Collectively, our theoretical and experimental findings reveal the structural basis of material PTs in an organismal context."}],"_id":"9316","date_published":"2021-04-01T00:00:00Z","article_processing_charge":"No","issue":"7","external_id":{"isi":["000636734000022"],"pmid":["33730596"]},"scopus_import":"1","date_updated":"2023-08-07T14:33:59Z","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","acknowledged_ssus":[{"_id":"Bio"},{"_id":"PreCl"}],"publication_identifier":{"issn":["00928674"],"eissn":["10974172"]},"article_type":"original","oa_version":"Published Version","year":"2021","has_accepted_license":"1","publication":"Cell","quality_controlled":"1","department":[{"_id":"CaHe"},{"_id":"EdHa"}],"intvolume":"       184","status":"public","publisher":"Elsevier","isi":1,"month":"04","date_created":"2021-04-11T22:01:14Z","page":"1914-1928.e19","language":[{"iso":"eng"}],"doi":"10.1016/j.cell.2021.02.017","ddc":["570"],"pmid":1,"project":[{"name":"Interaction and feedback between cell mechanics and fate specification in vertebrate gastrulation","grant_number":"742573","_id":"260F1432-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"},{"grant_number":"851288","name":"Design Principles of Branching Morphogenesis","_id":"05943252-7A3F-11EA-A408-12923DDC885E","call_identifier":"H2020"},{"grant_number":"V00736","name":"Tissue material properties in embryonic development","_id":"2693FD8C-B435-11E9-9278-68D0E5697425","call_identifier":"FWF"}],"related_material":{"link":[{"description":"News on IST Homepage","url":"https://ist.ac.at/en/news/embryonic-tissue-undergoes-phase-transition/","relation":"press_release"}]},"acknowledgement":"We thank Carl Goodrich and the members of the Heisenberg and Hannezo groups, in particular Reka Korei, for help, technical advice, and discussions; and the Bioimaging and zebrafish facilities of the IST Austria for continuous support. This work was supported by the Elise Richter Program of Austrian Science Fund (FWF) to N.I.P. ( V 736-B26 ) and the European Union (European Research Council Advanced Grant 742573 to C.-P.H. and European Research Council Starting Grant 851288 to E.H.).","day":"01","author":[{"full_name":"Petridou, Nicoletta","first_name":"Nicoletta","last_name":"Petridou","orcid":"0000-0002-8451-1195","id":"2A003F6C-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Corominas-Murtra","first_name":"Bernat","full_name":"Corominas-Murtra, Bernat","orcid":"0000-0001-9806-5643","id":"43BE2298-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Heisenberg","first_name":"Carl-Philipp J","full_name":"Heisenberg, Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0912-4566"},{"last_name":"Hannezo","full_name":"Hannezo, Edouard B","first_name":"Edouard B","orcid":"0000-0001-6005-1561","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87"}],"type":"journal_article","citation":{"short":"N. Petridou, B. Corominas-Murtra, C.-P.J. Heisenberg, E.B. Hannezo, Cell 184 (2021) 1914–1928.e19.","ama":"Petridou N, Corominas-Murtra B, Heisenberg C-PJ, Hannezo EB. Rigidity percolation uncovers a structural basis for embryonic tissue phase transitions. <i>Cell</i>. 2021;184(7):1914-1928.e19. doi:<a href=\"https://doi.org/10.1016/j.cell.2021.02.017\">10.1016/j.cell.2021.02.017</a>","apa":"Petridou, N., Corominas-Murtra, B., Heisenberg, C.-P. J., &#38; Hannezo, E. B. (2021). Rigidity percolation uncovers a structural basis for embryonic tissue phase transitions. <i>Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cell.2021.02.017\">https://doi.org/10.1016/j.cell.2021.02.017</a>","chicago":"Petridou, Nicoletta, Bernat Corominas-Murtra, Carl-Philipp J Heisenberg, and Edouard B Hannezo. “Rigidity Percolation Uncovers a Structural Basis for Embryonic Tissue Phase Transitions.” <i>Cell</i>. Elsevier, 2021. <a href=\"https://doi.org/10.1016/j.cell.2021.02.017\">https://doi.org/10.1016/j.cell.2021.02.017</a>.","ieee":"N. Petridou, B. Corominas-Murtra, C.-P. J. Heisenberg, and E. B. Hannezo, “Rigidity percolation uncovers a structural basis for embryonic tissue phase transitions,” <i>Cell</i>, vol. 184, no. 7. Elsevier, p. 1914–1928.e19, 2021.","ista":"Petridou N, Corominas-Murtra B, Heisenberg C-PJ, Hannezo EB. 2021. Rigidity percolation uncovers a structural basis for embryonic tissue phase transitions. Cell. 184(7), 1914–1928.e19.","mla":"Petridou, Nicoletta, et al. “Rigidity Percolation Uncovers a Structural Basis for Embryonic Tissue Phase Transitions.” <i>Cell</i>, vol. 184, no. 7, Elsevier, 2021, p. 1914–1928.e19, doi:<a href=\"https://doi.org/10.1016/j.cell.2021.02.017\">10.1016/j.cell.2021.02.017</a>."},"ec_funded":1,"title":"Rigidity percolation uncovers a structural basis for embryonic tissue phase transitions"},{"article_type":"review","has_accepted_license":"1","year":"2019","oa_version":"Published Version","external_id":{"pmid":["31512749"],"isi":["000485561900001"]},"scopus_import":"1","date_updated":"2023-09-05T13:04:13Z","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","publication_identifier":{"issn":["0261-4189"],"eissn":["1460-2075"]},"article_processing_charge":"Yes (via OA deal)","issue":"20","article_number":"e102497","file":[{"file_name":"2019_Embo_Petridou.pdf","file_size":847356,"creator":"dernst","checksum":"76f7f4e79ab6d850c30017a69726fd85","date_updated":"2020-07-14T12:47:46Z","access_level":"open_access","content_type":"application/pdf","relation":"main_file","file_id":"6981","date_created":"2019-11-04T15:30:08Z"}],"abstract":[{"text":"Tissue morphogenesis in multicellular organisms is brought about by spatiotemporal coordination of mechanical and chemical signals. Extensive work on how mechanical forces together with the well‐established morphogen signalling pathways can actively shape living tissues has revealed evolutionary conserved mechanochemical features of embryonic development. More recently, attention has been drawn to the description of tissue material properties and how they can influence certain morphogenetic processes. Interestingly, besides the role of tissue material properties in determining how much tissues deform in response to force application, there is increasing theoretical and experimental evidence, suggesting that tissue material properties can abruptly and drastically change in development. These changes resemble phase transitions, pointing at the intriguing possibility that important morphogenetic processes in development, such as symmetry breaking and self‐organization, might be mediated by tissue phase transitions. In this review, we summarize recent findings on the regulation and role of tissue material properties in the context of the developing embryo. We posit that abrupt changes of tissue rheological properties may have important implications in maintaining the balance between robustness and adaptability during embryonic development.","lang":"eng"}],"_id":"6980","date_published":"2019-10-15T00:00:00Z","publication_status":"published","oa":1,"file_date_updated":"2020-07-14T12:47:46Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"volume":38,"citation":{"chicago":"Petridou, Nicoletta, and Carl-Philipp J Heisenberg. “Tissue Rheology in Embryonic Organization.” <i>The EMBO Journal</i>. EMBO, 2019. <a href=\"https://doi.org/10.15252/embj.2019102497\">https://doi.org/10.15252/embj.2019102497</a>.","ieee":"N. Petridou and C.-P. J. Heisenberg, “Tissue rheology in embryonic organization,” <i>The EMBO Journal</i>, vol. 38, no. 20. EMBO, 2019.","ista":"Petridou N, Heisenberg C-PJ. 2019. Tissue rheology in embryonic organization. The EMBO Journal. 38(20), e102497.","mla":"Petridou, Nicoletta, and Carl-Philipp J. Heisenberg. “Tissue Rheology in Embryonic Organization.” <i>The EMBO Journal</i>, vol. 38, no. 20, e102497, EMBO, 2019, doi:<a href=\"https://doi.org/10.15252/embj.2019102497\">10.15252/embj.2019102497</a>.","short":"N. Petridou, C.-P.J. Heisenberg, The EMBO Journal 38 (2019).","ama":"Petridou N, Heisenberg C-PJ. Tissue rheology in embryonic organization. <i>The EMBO Journal</i>. 2019;38(20). doi:<a href=\"https://doi.org/10.15252/embj.2019102497\">10.15252/embj.2019102497</a>","apa":"Petridou, N., &#38; Heisenberg, C.-P. J. (2019). Tissue rheology in embryonic organization. <i>The EMBO Journal</i>. EMBO. <a href=\"https://doi.org/10.15252/embj.2019102497\">https://doi.org/10.15252/embj.2019102497</a>"},"ec_funded":1,"title":"Tissue rheology in embryonic organization","day":"15","type":"journal_article","author":[{"orcid":"0000-0002-8451-1195","id":"2A003F6C-F248-11E8-B48F-1D18A9856A87","full_name":"Petridou, Nicoletta","first_name":"Nicoletta","last_name":"Petridou"},{"id":"39427864-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0912-4566","last_name":"Heisenberg","first_name":"Carl-Philipp J","full_name":"Heisenberg, Carl-Philipp J"}],"project":[{"name":"Interaction and feedback between cell mechanics and fate specification in vertebrate gastrulation","grant_number":"742573","call_identifier":"H2020","_id":"260F1432-B435-11E9-9278-68D0E5697425"},{"grant_number":"V00736","name":"Tissue material properties in embryonic development","_id":"2693FD8C-B435-11E9-9278-68D0E5697425","call_identifier":"FWF"}],"pmid":1,"language":[{"iso":"eng"}],"doi":"10.15252/embj.2019102497","ddc":["570"],"month":"10","date_created":"2019-11-04T15:24:29Z","publisher":"EMBO","isi":1,"publication":"The EMBO Journal","department":[{"_id":"CaHe"}],"quality_controlled":"1","intvolume":"        38","status":"public"}]