---
_id: '8602'
abstract:
- lang: eng
text: Collective cell migration offers a rich field of study for non-equilibrium
physics and cellular biology, revealing phenomena such as glassy dynamics, pattern
formation and active turbulence. However, how mechanical and chemical signalling
are integrated at the cellular level to give rise to such collective behaviours
remains unclear. We address this by focusing on the highly conserved phenomenon
of spatiotemporal waves of density and extracellular signal-regulated kinase (ERK)
activation, which appear both in vitro and in vivo during collective cell migration
and wound healing. First, we propose a biophysical theory, backed by mechanical
and optogenetic perturbation experiments, showing that patterns can be quantitatively
explained by a mechanochemical coupling between active cellular tensions and the
mechanosensitive ERK pathway. Next, we demonstrate how this biophysical mechanism
can robustly induce long-ranged order and migration in a desired orientation,
and we determine the theoretically optimal wavelength and period for inducing
maximal migration towards free edges, which fits well with experimentally observed
dynamics. We thereby provide a bridge between the biophysical origin of spatiotemporal
instabilities and the design principles of robust and efficient long-ranged migration.
acknowledgement: We would like to thank G. Tkacik and all of the members of the Hannezo
and Hirashima groups for useful discussions, X. Trepat for help on traction force
microscopy and M. Matsuda for use of the lab facility. E.H. acknowledges grants
from the Austrian Science Fund (FWF) (P 31639) and the European Research Council
(851288). T.H. acknowledges a grant from JST, PRESTO (JPMJPR1949). This project
has received funding from the European Union’s Horizon 2020 research and innovation
programme under the Marie Skłodowska-Curie grant agreement no. 665385 (to D.B.),
from JSPS KAKENHI grant no. 17J02107 (to N.H.) and from the SPIRITS 2018 of Kyoto
University (to E.H. and T.H.).
article_processing_charge: No
article_type: original
author:
- first_name: Daniel R
full_name: Boocock, Daniel R
id: 453AF628-F248-11E8-B48F-1D18A9856A87
last_name: Boocock
orcid: 0000-0002-1585-2631
- first_name: Naoya
full_name: Hino, Naoya
last_name: Hino
- first_name: Natalia
full_name: Ruzickova, Natalia
id: D2761128-D73D-11E9-A1BF-BA0DE6697425
last_name: Ruzickova
- first_name: Tsuyoshi
full_name: Hirashima, Tsuyoshi
last_name: Hirashima
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
citation:
ama: Boocock DR, Hino N, Ruzickova N, Hirashima T, Hannezo EB. Theory of mechanochemical
patterning and optimal migration in cell monolayers. Nature Physics. 2021;17:267-274.
doi:10.1038/s41567-020-01037-7
apa: Boocock, D. R., Hino, N., Ruzickova, N., Hirashima, T., & Hannezo, E. B.
(2021). Theory of mechanochemical patterning and optimal migration in cell monolayers.
Nature Physics. Springer Nature. https://doi.org/10.1038/s41567-020-01037-7
chicago: Boocock, Daniel R, Naoya Hino, Natalia Ruzickova, Tsuyoshi Hirashima, and
Edouard B Hannezo. “Theory of Mechanochemical Patterning and Optimal Migration
in Cell Monolayers.” Nature Physics. Springer Nature, 2021. https://doi.org/10.1038/s41567-020-01037-7.
ieee: D. R. Boocock, N. Hino, N. Ruzickova, T. Hirashima, and E. B. Hannezo, “Theory
of mechanochemical patterning and optimal migration in cell monolayers,” Nature
Physics, vol. 17. Springer Nature, pp. 267–274, 2021.
ista: Boocock DR, Hino N, Ruzickova N, Hirashima T, Hannezo EB. 2021. Theory of
mechanochemical patterning and optimal migration in cell monolayers. Nature Physics.
17, 267–274.
mla: Boocock, Daniel R., et al. “Theory of Mechanochemical Patterning and Optimal
Migration in Cell Monolayers.” Nature Physics, vol. 17, Springer Nature,
2021, pp. 267–74, doi:10.1038/s41567-020-01037-7.
short: D.R. Boocock, N. Hino, N. Ruzickova, T. Hirashima, E.B. Hannezo, Nature Physics
17 (2021) 267–274.
date_created: 2020-10-04T22:01:37Z
date_published: 2021-02-01T00:00:00Z
date_updated: 2023-08-04T11:02:41Z
day: '01'
department:
- _id: EdHa
doi: 10.1038/s41567-020-01037-7
ec_funded: 1
external_id:
isi:
- '000573519500002'
intvolume: ' 17'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/2020.05.15.096479
month: '02'
oa: 1
oa_version: Preprint
page: 267-274
project:
- _id: 268294B6-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P31639
name: Active mechano-chemical description of the cell cytoskeleton
- _id: 05943252-7A3F-11EA-A408-12923DDC885E
call_identifier: H2020
grant_number: '851288'
name: Design Principles of Branching Morphogenesis
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication: Nature Physics
publication_identifier:
eissn:
- '17452481'
issn:
- '17452473'
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/wound-healing-waves/
record:
- id: '12964'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Theory of mechanochemical patterning and optimal migration in cell monolayers
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 17
year: '2021'
...
---
_id: '9306'
abstract:
- lang: eng
text: Assemblies of actin and its regulators underlie the dynamic morphology of
all eukaryotic cells. To understand how actin regulatory proteins work together
to generate actin-rich structures such as filopodia, we analyzed the localization
of diverse actin regulators within filopodia in Drosophila embryos and in a complementary
in vitro system of filopodia-like structures (FLSs). We found that the composition
of the regulatory protein complex where actin is incorporated (the filopodial
tip complex) is remarkably heterogeneous both in vivo and in vitro. Our data reveal
that different pairs of proteins correlate with each other and with actin bundle
length, suggesting the presence of functional subcomplexes. This is consistent
with a theoretical framework where three or more redundant subcomplexes join the
tip complex stochastically, with any two being sufficient to drive filopodia formation.
We provide an explanation for the observed heterogeneity and suggest that a mechanism
based on multiple components allows stereotypical filopodial dynamics to arise
from diverse upstream signaling pathways.
acknowledgement: "This work was supported by European Research Council grant 281971,
Wellcome Trust Research Career Development Fellowship WT095829AIA and Wellcome Trust
Senior Research\r\nFellowship 219482/Z/19/Z to J.L. Gallop, a Wellcome Trust Senior
Investigator Award 098357 to B.D. Simons, and an Austrian Science Fund grant (P31639)
to E. Hannezo. We acknowledge\r\ncore funding by the Wellcome Trust (092096) and
Cancer Research UK (C6946/A14492). U. Dobramysl was supported by a Wellcome Trust
Junior Interdisciplinary Fellowship grant\r\n(105602/Z/14/Z) and a Herchel Smith
Postdoctoral Fellowship. H. Shimo was supported by a Funai Foundation Overseas scholarship."
article_number: e202003052
article_processing_charge: No
article_type: original
author:
- first_name: Ulrich
full_name: Dobramysl, Ulrich
last_name: Dobramysl
- first_name: Iris Katharina
full_name: Jarsch, Iris Katharina
last_name: Jarsch
- first_name: Yoshiko
full_name: Inoue, Yoshiko
last_name: Inoue
- first_name: Hanae
full_name: Shimo, Hanae
last_name: Shimo
- first_name: Benjamin
full_name: Richier, Benjamin
last_name: Richier
- first_name: Jonathan R.
full_name: Gadsby, Jonathan R.
last_name: Gadsby
- first_name: Julia
full_name: Mason, Julia
last_name: Mason
- first_name: Alicja
full_name: Szałapak, Alicja
last_name: Szałapak
- first_name: Pantelis Savvas
full_name: Ioannou, Pantelis Savvas
last_name: Ioannou
- first_name: Guilherme Pereira
full_name: Correia, Guilherme Pereira
last_name: Correia
- first_name: Astrid
full_name: Walrant, Astrid
last_name: Walrant
- first_name: Richard
full_name: Butler, Richard
last_name: Butler
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
- first_name: Benjamin D.
full_name: Simons, Benjamin D.
last_name: Simons
- first_name: Jennifer L.
full_name: Gallop, Jennifer L.
last_name: Gallop
citation:
ama: Dobramysl U, Jarsch IK, Inoue Y, et al. Stochastic combinations of actin regulatory
proteins are sufficient to drive filopodia formation. Journal of Cell Biology.
2021;220(4). doi:10.1083/jcb.202003052
apa: Dobramysl, U., Jarsch, I. K., Inoue, Y., Shimo, H., Richier, B., Gadsby, J.
R., … Gallop, J. L. (2021). Stochastic combinations of actin regulatory proteins
are sufficient to drive filopodia formation. Journal of Cell Biology. Rockefeller
University Press. https://doi.org/10.1083/jcb.202003052
chicago: Dobramysl, Ulrich, Iris Katharina Jarsch, Yoshiko Inoue, Hanae Shimo, Benjamin
Richier, Jonathan R. Gadsby, Julia Mason, et al. “Stochastic Combinations of Actin
Regulatory Proteins Are Sufficient to Drive Filopodia Formation.” Journal of
Cell Biology. Rockefeller University Press, 2021. https://doi.org/10.1083/jcb.202003052.
ieee: U. Dobramysl et al., “Stochastic combinations of actin regulatory proteins
are sufficient to drive filopodia formation,” Journal of Cell Biology,
vol. 220, no. 4. Rockefeller University Press, 2021.
ista: Dobramysl U, Jarsch IK, Inoue Y, Shimo H, Richier B, Gadsby JR, Mason J, Szałapak
A, Ioannou PS, Correia GP, Walrant A, Butler R, Hannezo EB, Simons BD, Gallop
JL. 2021. Stochastic combinations of actin regulatory proteins are sufficient
to drive filopodia formation. Journal of Cell Biology. 220(4), e202003052.
mla: Dobramysl, Ulrich, et al. “Stochastic Combinations of Actin Regulatory Proteins
Are Sufficient to Drive Filopodia Formation.” Journal of Cell Biology,
vol. 220, no. 4, e202003052, Rockefeller University Press, 2021, doi:10.1083/jcb.202003052.
short: U. Dobramysl, I.K. Jarsch, Y. Inoue, H. Shimo, B. Richier, J.R. Gadsby, J.
Mason, A. Szałapak, P.S. Ioannou, G.P. Correia, A. Walrant, R. Butler, E.B. Hannezo,
B.D. Simons, J.L. Gallop, Journal of Cell Biology 220 (2021).
date_created: 2021-04-04T22:01:21Z
date_published: 2021-03-19T00:00:00Z
date_updated: 2023-08-07T14:32:28Z
day: '19'
ddc:
- '576'
department:
- _id: EdHa
doi: 10.1083/jcb.202003052
external_id:
isi:
- '000663160600002'
pmid:
- '33740033'
file:
- access_level: open_access
checksum: 4739ffd90f2c7e05ac5b00f057c58aa2
content_type: application/pdf
creator: dernst
date_created: 2021-04-06T10:39:08Z
date_updated: 2021-04-06T10:39:08Z
file_id: '9310'
file_name: 2021_JCB_Dobramysl.pdf
file_size: 9019720
relation: main_file
success: 1
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intvolume: ' 220'
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issue: '4'
language:
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month: '03'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 268294B6-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P31639
name: Active mechano-chemical description of the cell cytoskeleton
publication: Journal of Cell Biology
publication_identifier:
eissn:
- '15408140'
publication_status: published
publisher: Rockefeller University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Stochastic combinations of actin regulatory proteins are sufficient to drive
filopodia formation
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 220
year: '2021'
...
---
_id: '9349'
abstract:
- lang: eng
text: 'The way in which interactions between mechanics and biochemistry lead to
the emergence of complex cell and tissue organization is an old question that
has recently attracted renewed interest from biologists, physicists, mathematicians
and computer scientists. Rapid advances in optical physics, microscopy and computational
image analysis have greatly enhanced our ability to observe and quantify spatiotemporal
patterns of signalling, force generation, deformation, and flow in living cells
and tissues. Powerful new tools for genetic, biophysical and optogenetic manipulation
are allowing us to perturb the underlying machinery that generates these patterns
in increasingly sophisticated ways. Rapid advances in theory and computing have
made it possible to construct predictive models that describe how cell and tissue
organization and dynamics emerge from the local coupling of biochemistry and mechanics.
Together, these advances have opened up a wealth of new opportunities to explore
how mechanochemical patterning shapes organismal development. In this roadmap,
we present a series of forward-looking case studies on mechanochemical patterning
in development, written by scientists working at the interface between the physical
and biological sciences, and covering a wide range of spatial and temporal scales,
organisms, and modes of development. Together, these contributions highlight the
many ways in which the dynamic coupling of mechanics and biochemistry shapes biological
dynamics: from mechanoenzymes that sense force to tune their activity and motor
output, to collectives of cells in tissues that flow and redistribute biochemical
signals during development.'
acknowledgement: The AK group is supported by IST Austria and by the ERC under European
Union Horizon 2020 research and innovation programme Grant 680037. Apologies to
those whose work could not be mentioned due to limited space. We thank all my lab
members, both past and present, for stimulating discussion. This work was funded
by a Singapore Ministry of Education Tier 3 Grant, MOE2016-T3-1-005. We thank Francis
Corson for continuous discussion and collaboration contributing to these views and
for figure 4(A). PC is sponsored by the Institut Pasteur and the European Union's
Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie
Grant Agreement No. 665807. Research in JG's laboratory is funded by the European
Research Council under the European Union's Seventh Framework Programme (FP7/2007-2013)/ERC
Grant Agreement No. 337635, Institut Pasteur, CNRS, Cercle FSER, Fondation pour
la Recherche Medicale, the Vallee Foundation and the ANR-19-CE-13-0024 Grant. We
thank Erez Braun and Alex Mogilner for comments on the manuscript and Niv Ierushalmi
for help with figure 5. This project has received funding from the European Union's
Horizon 2020 research and innovation programme under Grant Agreement No. ERC-2018-COG
Grant 819174-HydraMechanics awarded to KK. EH thanks all lab members, as well as
Pierre Recho, Tsuyoshi Hirashima, Diana Pinheiro and Carl-Philip Heisenberg, for
fruitful discussions on these topics—and apologize for not being able to cite many
very relevant publications due to the strict 10-reference limit. EH acknowledges
the support of Austrian Science Fund (FWF) (P 31639) and the European Research Council
under the European Union's Horizon 2020 Research and Innovation Programme Grant
Agreements (851288). The authors acknowledge the inspiring scientists whose work
could not be cited in this perspective due to space constraints; the members of
the Gartner Lab for helpful discussions; the Barbara and Gerson Bakar Foundation,
the Chan Zuckerberg Biohub Investigators Programme, the National Institute of Health,
and the Centre for Cellular Construction, an NSF Science and Technology Centre.
The Minc laboratory is currently funded by the CNRS and the European Research Council
(CoG Forcaster No. 647073). Research in the lab of J-LM is supported by the Institut
Curie, the Centre National de la Recherche Scientifique (CNRS), the Institut National
de la Santé Et de la Recherche Médicale (INSERM), and is funded by grants from the
ATIP-Avenir programme, the Fondation Schlumberger pour l'Éducation et la Recherche
via the Fondation pour la Recherche Médicale, the European Research Council Starting
Grant ERC-2017-StG 757557, the European Molecular Biology Organization Young Investigator
programme (EMBO YIP), the INSERM transversal programme Human Development Cell Atlas
(HuDeCA), Paris Sciences Lettres (PSL) 'nouvelle équipe' and QLife (17-CONV-0005)
grants and Labex DEEP (ANR-11-LABX-0044) which are part of the IDEX PSL (ANR-10-IDEX-0001-02).
We acknowledge useful discussions with Massimo Vergassola, Sebastian Streichan and
my lab members. Work in my laboratory on Drosophila embryogenesis is partly supported
by NIH-R01GM122936. The authors acknowledge the support by a grant from the European
Research Council (Grant No. 682161). Lenne group is funded by a grant from the 'Investissements
d'Avenir' French Government programme managed by the French National Research Agency
(ANR-16-CONV-0001) and by the Excellence Initiative of Aix-Marseille University—A*MIDEX,
and ANR projects MechaResp (ANR-17-CE13-0032) and AdGastrulo (ANR-19-CE13-0022).
article_number: '041501'
article_processing_charge: No
article_type: original
author:
- first_name: Pierre François
full_name: Lenne, Pierre François
last_name: Lenne
- first_name: Edwin
full_name: Munro, Edwin
last_name: Munro
- first_name: Idse
full_name: Heemskerk, Idse
last_name: Heemskerk
- first_name: Aryeh
full_name: Warmflash, Aryeh
last_name: Warmflash
- first_name: Laura
full_name: Bocanegra, Laura
id: 4896F754-F248-11E8-B48F-1D18A9856A87
last_name: Bocanegra
- first_name: Kasumi
full_name: Kishi, Kasumi
id: 3065DFC4-F248-11E8-B48F-1D18A9856A87
last_name: Kishi
- first_name: Anna
full_name: Kicheva, Anna
id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
last_name: Kicheva
orcid: 0000-0003-4509-4998
- first_name: Yuchen
full_name: Long, Yuchen
last_name: Long
- first_name: Antoine
full_name: Fruleux, Antoine
last_name: Fruleux
- first_name: Arezki
full_name: Boudaoud, Arezki
last_name: Boudaoud
- first_name: Timothy E.
full_name: Saunders, Timothy E.
last_name: Saunders
- first_name: Paolo
full_name: Caldarelli, Paolo
last_name: Caldarelli
- first_name: Arthur
full_name: Michaut, Arthur
last_name: Michaut
- first_name: Jerome
full_name: Gros, Jerome
last_name: Gros
- first_name: Yonit
full_name: Maroudas-Sacks, Yonit
last_name: Maroudas-Sacks
- first_name: Kinneret
full_name: Keren, Kinneret
last_name: Keren
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
- first_name: Zev J.
full_name: Gartner, Zev J.
last_name: Gartner
- first_name: Benjamin
full_name: Stormo, Benjamin
last_name: Stormo
- first_name: Amy
full_name: Gladfelter, Amy
last_name: Gladfelter
- first_name: Alan
full_name: Rodrigues, Alan
last_name: Rodrigues
- first_name: Amy
full_name: Shyer, Amy
last_name: Shyer
- first_name: Nicolas
full_name: Minc, Nicolas
last_name: Minc
- first_name: Jean Léon
full_name: Maître, Jean Léon
last_name: Maître
- first_name: Stefano
full_name: Di Talia, Stefano
last_name: Di Talia
- first_name: Bassma
full_name: Khamaisi, Bassma
last_name: Khamaisi
- first_name: David
full_name: Sprinzak, David
last_name: Sprinzak
- first_name: Sham
full_name: Tlili, Sham
last_name: Tlili
citation:
ama: Lenne PF, Munro E, Heemskerk I, et al. Roadmap for the multiscale coupling
of biochemical and mechanical signals during development. Physical biology.
2021;18(4). doi:10.1088/1478-3975/abd0db
apa: Lenne, P. F., Munro, E., Heemskerk, I., Warmflash, A., Bocanegra, L., Kishi,
K., … Tlili, S. (2021). Roadmap for the multiscale coupling of biochemical and
mechanical signals during development. Physical Biology. IOP Publishing.
https://doi.org/10.1088/1478-3975/abd0db
chicago: Lenne, Pierre François, Edwin Munro, Idse Heemskerk, Aryeh Warmflash, Laura
Bocanegra, Kasumi Kishi, Anna Kicheva, et al. “Roadmap for the Multiscale Coupling
of Biochemical and Mechanical Signals during Development.” Physical Biology.
IOP Publishing, 2021. https://doi.org/10.1088/1478-3975/abd0db.
ieee: P. F. Lenne et al., “Roadmap for the multiscale coupling of biochemical
and mechanical signals during development,” Physical biology, vol. 18,
no. 4. IOP Publishing, 2021.
ista: Lenne PF, Munro E, Heemskerk I, Warmflash A, Bocanegra L, Kishi K, Kicheva
A, Long Y, Fruleux A, Boudaoud A, Saunders TE, Caldarelli P, Michaut A, Gros J,
Maroudas-Sacks Y, Keren K, Hannezo EB, Gartner ZJ, Stormo B, Gladfelter A, Rodrigues
A, Shyer A, Minc N, Maître JL, Di Talia S, Khamaisi B, Sprinzak D, Tlili S. 2021.
Roadmap for the multiscale coupling of biochemical and mechanical signals during
development. Physical biology. 18(4), 041501.
mla: Lenne, Pierre François, et al. “Roadmap for the Multiscale Coupling of Biochemical
and Mechanical Signals during Development.” Physical Biology, vol. 18,
no. 4, 041501, IOP Publishing, 2021, doi:10.1088/1478-3975/abd0db.
short: P.F. Lenne, E. Munro, I. Heemskerk, A. Warmflash, L. Bocanegra, K. Kishi,
A. Kicheva, Y. Long, A. Fruleux, A. Boudaoud, T.E. Saunders, P. Caldarelli, A.
Michaut, J. Gros, Y. Maroudas-Sacks, K. Keren, E.B. Hannezo, Z.J. Gartner, B.
Stormo, A. Gladfelter, A. Rodrigues, A. Shyer, N. Minc, J.L. Maître, S. Di Talia,
B. Khamaisi, D. Sprinzak, S. Tlili, Physical Biology 18 (2021).
date_created: 2021-04-25T22:01:29Z
date_published: 2021-04-14T00:00:00Z
date_updated: 2023-08-08T13:15:46Z
day: '14'
ddc:
- '570'
department:
- _id: AnKi
- _id: EdHa
doi: 10.1088/1478-3975/abd0db
ec_funded: 1
external_id:
isi:
- '000640396400001'
pmid:
- '33276350'
file:
- access_level: open_access
checksum: 4f52082549d3561c4c15d4d8d84ca5d8
content_type: application/pdf
creator: cziletti
date_created: 2021-04-27T08:38:35Z
date_updated: 2021-04-27T08:38:35Z
file_id: '9355'
file_name: 2021_PhysBio_Lenne.pdf
file_size: 6296324
relation: main_file
success: 1
file_date_updated: 2021-04-27T08:38:35Z
has_accepted_license: '1'
intvolume: ' 18'
isi: 1
issue: '4'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: B6FC0238-B512-11E9-945C-1524E6697425
call_identifier: H2020
grant_number: '680037'
name: Coordination of Patterning And Growth In the Spinal Cord
- _id: 268294B6-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P31639
name: Active mechano-chemical description of the cell cytoskeleton
- _id: 05943252-7A3F-11EA-A408-12923DDC885E
call_identifier: H2020
grant_number: '851288'
name: Design Principles of Branching Morphogenesis
publication: Physical biology
publication_identifier:
eissn:
- 1478-3975
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
related_material:
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relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Roadmap for the multiscale coupling of biochemical and mechanical signals during
development
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 18
year: '2021'
...
---
_id: '9629'
abstract:
- lang: eng
text: Intestinal organoids derived from single cells undergo complex crypt–villus
patterning and morphogenesis. However, the nature and coordination of the underlying
forces remains poorly characterized. Here, using light-sheet microscopy and large-scale
imaging quantification, we demonstrate that crypt formation coincides with a stark
reduction in lumen volume. We develop a 3D biophysical model to computationally
screen different mechanical scenarios of crypt morphogenesis. Combining this with
live-imaging data and multiple mechanical perturbations, we show that actomyosin-driven
crypt apical contraction and villus basal tension work synergistically with lumen
volume reduction to drive crypt morphogenesis, and demonstrate the existence of
a critical point in differential tensions above which crypt morphology becomes
robust to volume changes. Finally, we identified a sodium/glucose cotransporter
that is specific to differentiated enterocytes that modulates lumen volume reduction
through cell swelling in the villus region. Together, our study uncovers the cellular
basis of how cell fate modulates osmotic and actomyosin forces to coordinate robust
morphogenesis.
acknowledgement: 'We acknowledge the members of the Lennon-Duménil laboratory for
sharing the mouse line of Myh9-GFP. We are grateful to the members of the Liberali
laboratory and the FMI facilities for their support. We thank E. Tagliavini for
IT support; L. Gelman for assistance and training; S. Bichet and A. Bogucki for
helping with histology of mouse tissues; H. Kohler for fluorescence-activated cell
sorting; G. Q. G. de Medeiros for maintenance of light-sheet microscopy; M. G. Stadler
for scRNA-seq analysis; G. Gay for discussions on the 3D vertex model; the members
of the Liberali laboratory, C. P. Heisenberg and C. Tsiairis for reading and providing
feedback on the manuscript. Funding: Q.Y. is supported by a Postdoc fellowship from
Peter und Taul Engelhorn Stiftung (PTES). This work received funding from the European
Research Council (ERC) under the EU Horizon 2020 research and Innovation Programme
Grant Agreement no. 758617 (to P.L.), the Swiss National Foundation (SNF) (POOP3_157531,
to P.L.) and from the ERC under the EU Horizon 2020 Research and Innovation Program
Grant Agreements 851288 (to E.H.) and the Austrian Science Fund (FWF) (P31639, to
E.H.).'
article_processing_charge: No
article_type: original
author:
- first_name: Qiutan
full_name: Yang, Qiutan
last_name: Yang
- first_name: Shi-lei
full_name: Xue, Shi-lei
id: 31D2C804-F248-11E8-B48F-1D18A9856A87
last_name: Xue
- first_name: Chii Jou
full_name: Chan, Chii Jou
last_name: Chan
- first_name: Markus
full_name: Rempfler, Markus
last_name: Rempfler
- first_name: Dario
full_name: Vischi, Dario
last_name: Vischi
- first_name: Francisca
full_name: Maurer-Gutierrez, Francisca
last_name: Maurer-Gutierrez
- first_name: Takashi
full_name: Hiiragi, Takashi
last_name: Hiiragi
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
- first_name: Prisca
full_name: Liberali, Prisca
last_name: Liberali
citation:
ama: Yang Q, Xue S, Chan CJ, et al. Cell fate coordinates mechano-osmotic forces
in intestinal crypt formation. Nature Cell Biology. 2021;23:733–744. doi:10.1038/s41556-021-00700-2
apa: Yang, Q., Xue, S., Chan, C. J., Rempfler, M., Vischi, D., Maurer-Gutierrez,
F., … Liberali, P. (2021). Cell fate coordinates mechano-osmotic forces in intestinal
crypt formation. Nature Cell Biology. Springer Nature. https://doi.org/10.1038/s41556-021-00700-2
chicago: Yang, Qiutan, Shi-lei Xue, Chii Jou Chan, Markus Rempfler, Dario Vischi,
Francisca Maurer-Gutierrez, Takashi Hiiragi, Edouard B Hannezo, and Prisca Liberali.
“Cell Fate Coordinates Mechano-Osmotic Forces in Intestinal Crypt Formation.”
Nature Cell Biology. Springer Nature, 2021. https://doi.org/10.1038/s41556-021-00700-2.
ieee: Q. Yang et al., “Cell fate coordinates mechano-osmotic forces in intestinal
crypt formation,” Nature Cell Biology, vol. 23. Springer Nature, pp. 733–744,
2021.
ista: Yang Q, Xue S, Chan CJ, Rempfler M, Vischi D, Maurer-Gutierrez F, Hiiragi
T, Hannezo EB, Liberali P. 2021. Cell fate coordinates mechano-osmotic forces
in intestinal crypt formation. Nature Cell Biology. 23, 733–744.
mla: Yang, Qiutan, et al. “Cell Fate Coordinates Mechano-Osmotic Forces in Intestinal
Crypt Formation.” Nature Cell Biology, vol. 23, Springer Nature, 2021,
pp. 733–744, doi:10.1038/s41556-021-00700-2.
short: Q. Yang, S. Xue, C.J. Chan, M. Rempfler, D. Vischi, F. Maurer-Gutierrez,
T. Hiiragi, E.B. Hannezo, P. Liberali, Nature Cell Biology 23 (2021) 733–744.
date_created: 2021-07-04T22:01:25Z
date_published: 2021-06-21T00:00:00Z
date_updated: 2023-08-10T13:57:36Z
day: '21'
department:
- _id: EdHa
doi: 10.1038/s41556-021-00700-2
ec_funded: 1
external_id:
isi:
- '000664016300003'
pmid:
- '34155381'
intvolume: ' 23'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.biorxiv.org/content/10.1101/2020.05.13.094359
month: '06'
oa: 1
oa_version: Preprint
page: 733–744
pmid: 1
project:
- _id: 05943252-7A3F-11EA-A408-12923DDC885E
call_identifier: H2020
grant_number: '851288'
name: Design Principles of Branching Morphogenesis
- _id: 268294B6-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P31639
name: Active mechano-chemical description of the cell cytoskeleton
publication: Nature Cell Biology
publication_identifier:
eissn:
- 1476-4679
issn:
- 1465-7392
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Cell fate coordinates mechano-osmotic forces in intestinal crypt formation
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 23
year: '2021'
...
---
_id: '10365'
abstract:
- lang: eng
text: The early development of many organisms involves the folding of cell monolayers,
but this behaviour is difficult to reproduce in vitro; therefore, both mechanistic
causes and effects of local curvature remain unclear. Here we study epithelial
cell monolayers on corrugated hydrogels engineered into wavy patterns, examining
how concave and convex curvatures affect cellular and nuclear shape. We find that
substrate curvature affects monolayer thickness, which is larger in valleys than
crests. We show that this feature generically arises in a vertex model, leading
to the hypothesis that cells may sense curvature by modifying the thickness of
the tissue. We find that local curvature also affects nuclear morphology and positioning,
which we explain by extending the vertex model to take into account membrane–nucleus
interactions, encoding thickness modulation in changes to nuclear deformation
and position. We propose that curvature governs the spatial distribution of yes-associated
proteins via nuclear shape and density changes. We show that curvature also induces
significant variations in lamins, chromatin condensation and cell proliferation
rate in folded epithelial tissues. Together, this work identifies active cell
mechanics and nuclear mechanoadaptation as the key players of the mechanistic
regulation of epithelia to substrate curvature.
acknowledgement: S.G. acknowledges funding from FEDER Prostem Research Project no.
1510614 (Wallonia DG06), F.R.S.-FNRS Epiforce Research Project no. T.0092.21 and
Interreg MAT(T)ISSE project, which is financially supported by Interreg France-Wallonie-Vlaanderen
(Fonds Européen de Développement Régional, FEDER-ERDF). This project was supported
by the European Research Council under the European Union’s Horizon 2020 Research
and Innovation Programme grant agreement 851288 (to E.H.), and by the Austrian Science
Fund (FWF) (P 31639; to E.H.). L.R.M. acknowledges funding from the Agence National
de la Recherche (ANR), as part of the ‘Investments d’Avenir’ Programme (I-SITE ULNE/ANR-16-IDEX-0004
ULNE). This work benefited from ANR-10-EQPX-04-01 and FEDER 12001407 grants to F.L.
W.D.V. is supported by the Research Foundation Flanders (FWO 1516619N, FWO GOO5819N,
FWO I003420N, FWO IRI I000321N) and is member of the Research Excellence Consortium
µNEURO at the University of Antwerp. M.L. is financially supported by FRIA (F.R.S.-FNRS).
M.S. is a Senior Research Associate of the Fund for Scientific Research (F.R.S.-FNRS)
and acknowledges EOS grant no. 30650939 (PRECISION). Sketches in Figs. 1a and 5e
and Extended Data Fig. 9 were drawn by C. Levicek.
article_processing_charge: No
article_type: original
author:
- first_name: Marine
full_name: Luciano, Marine
last_name: Luciano
- first_name: Shi-lei
full_name: Xue, Shi-lei
id: 31D2C804-F248-11E8-B48F-1D18A9856A87
last_name: Xue
- first_name: Winnok H.
full_name: De Vos, Winnok H.
last_name: De Vos
- first_name: Lorena
full_name: Redondo-Morata, Lorena
last_name: Redondo-Morata
- first_name: Mathieu
full_name: Surin, Mathieu
last_name: Surin
- first_name: Frank
full_name: Lafont, Frank
last_name: Lafont
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
- first_name: Sylvain
full_name: Gabriele, Sylvain
last_name: Gabriele
citation:
ama: Luciano M, Xue S, De Vos WH, et al. Cell monolayers sense curvature by exploiting
active mechanics and nuclear mechanoadaptation. Nature Physics. 2021;17(12):1382–1390.
doi:10.1038/s41567-021-01374-1
apa: Luciano, M., Xue, S., De Vos, W. H., Redondo-Morata, L., Surin, M., Lafont,
F., … Gabriele, S. (2021). Cell monolayers sense curvature by exploiting active
mechanics and nuclear mechanoadaptation. Nature Physics. Springer Nature.
https://doi.org/10.1038/s41567-021-01374-1
chicago: Luciano, Marine, Shi-lei Xue, Winnok H. De Vos, Lorena Redondo-Morata,
Mathieu Surin, Frank Lafont, Edouard B Hannezo, and Sylvain Gabriele. “Cell Monolayers
Sense Curvature by Exploiting Active Mechanics and Nuclear Mechanoadaptation.”
Nature Physics. Springer Nature, 2021. https://doi.org/10.1038/s41567-021-01374-1.
ieee: M. Luciano et al., “Cell monolayers sense curvature by exploiting active
mechanics and nuclear mechanoadaptation,” Nature Physics, vol. 17, no.
12. Springer Nature, pp. 1382–1390, 2021.
ista: Luciano M, Xue S, De Vos WH, Redondo-Morata L, Surin M, Lafont F, Hannezo
EB, Gabriele S. 2021. Cell monolayers sense curvature by exploiting active mechanics
and nuclear mechanoadaptation. Nature Physics. 17(12), 1382–1390.
mla: Luciano, Marine, et al. “Cell Monolayers Sense Curvature by Exploiting Active
Mechanics and Nuclear Mechanoadaptation.” Nature Physics, vol. 17, no.
12, Springer Nature, 2021, pp. 1382–1390, doi:10.1038/s41567-021-01374-1.
short: M. Luciano, S. Xue, W.H. De Vos, L. Redondo-Morata, M. Surin, F. Lafont,
E.B. Hannezo, S. Gabriele, Nature Physics 17 (2021) 1382–1390.
date_created: 2021-11-28T23:01:29Z
date_published: 2021-11-18T00:00:00Z
date_updated: 2023-10-16T06:31:54Z
day: '18'
ddc:
- '530'
department:
- _id: EdHa
doi: 10.1038/s41567-021-01374-1
ec_funded: 1
external_id:
isi:
- '000720204300004'
file:
- access_level: open_access
checksum: 5d6d76750a71d7cb632bb15417c38ef7
content_type: application/pdf
creator: channezo
date_created: 2023-10-11T09:31:43Z
date_updated: 2023-10-11T09:31:43Z
file_id: '14420'
file_name: 50145_4_merged_1630498627.pdf
file_size: 40285498
relation: main_file
success: 1
file_date_updated: 2023-10-11T09:31:43Z
has_accepted_license: '1'
intvolume: ' 17'
isi: 1
issue: '12'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Submitted Version
page: 1382–1390
project:
- _id: 05943252-7A3F-11EA-A408-12923DDC885E
call_identifier: H2020
grant_number: '851288'
name: Design Principles of Branching Morphogenesis
- _id: 268294B6-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P31639
name: Active mechano-chemical description of the cell cytoskeleton
publication: Nature Physics
publication_identifier:
eissn:
- 1745-2481
issn:
- 1745-2473
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on IST Webpage
relation: press_release
url: https://ist.ac.at/en/news/how-cells-feel-curvature/
scopus_import: '1'
status: public
title: Cell monolayers sense curvature by exploiting active mechanics and nuclear
mechanoadaptation
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2021'
...
---
_id: '6191'
abstract:
- lang: eng
text: The formation of self-organized patterns is key to the morphogenesis of multicellular
organisms, although a comprehensive theory of biological pattern formation is
still lacking. Here, we propose a minimal model combining tissue mechanics with
morphogen turnover and transport to explore routes to patterning. Our active description
couples morphogen reaction and diffusion, which impact cell differentiation and
tissue mechanics, to a two-phase poroelastic rheology, where one tissue phase
consists of a poroelastic cell network and the other one of a permeating extracellular
fluid, which provides a feedback by actively transporting morphogens. While this
model encompasses previous theories approximating tissues to inert monophasic
media, such as Turing’s reaction–diffusion model, it overcomes some of their key
limitations permitting pattern formation via any two-species biochemical kinetics
due to mechanically induced cross-diffusion flows. Moreover, we describe a qualitatively
different advection-driven Keller–Segel instability which allows for the formation
of patterns with a single morphogen and whose fundamental mode pattern robustly
scales with tissue size. We discuss the potential relevance of these findings
for tissue morphogenesis.
article_processing_charge: No
author:
- first_name: Pierre
full_name: Recho, Pierre
last_name: Recho
- first_name: Adrien
full_name: Hallou, Adrien
last_name: Hallou
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
citation:
ama: Recho P, Hallou A, Hannezo EB. Theory of mechanochemical patterning in biphasic
biological tissues. Proceedings of the National Academy of Sciences of the
United States of America. 2019;116(12):5344-5349. doi:10.1073/pnas.1813255116
apa: Recho, P., Hallou, A., & Hannezo, E. B. (2019). Theory of mechanochemical
patterning in biphasic biological tissues. Proceedings of the National Academy
of Sciences of the United States of America. National Academy of Sciences.
https://doi.org/10.1073/pnas.1813255116
chicago: Recho, Pierre, Adrien Hallou, and Edouard B Hannezo. “Theory of Mechanochemical
Patterning in Biphasic Biological Tissues.” Proceedings of the National Academy
of Sciences of the United States of America. National Academy of Sciences,
2019. https://doi.org/10.1073/pnas.1813255116.
ieee: P. Recho, A. Hallou, and E. B. Hannezo, “Theory of mechanochemical patterning
in biphasic biological tissues,” Proceedings of the National Academy of Sciences
of the United States of America, vol. 116, no. 12. National Academy of Sciences,
pp. 5344–5349, 2019.
ista: Recho P, Hallou A, Hannezo EB. 2019. Theory of mechanochemical patterning
in biphasic biological tissues. Proceedings of the National Academy of Sciences
of the United States of America. 116(12), 5344–5349.
mla: Recho, Pierre, et al. “Theory of Mechanochemical Patterning in Biphasic Biological
Tissues.” Proceedings of the National Academy of Sciences of the United States
of America, vol. 116, no. 12, National Academy of Sciences, 2019, pp. 5344–49,
doi:10.1073/pnas.1813255116.
short: P. Recho, A. Hallou, E.B. Hannezo, Proceedings of the National Academy of
Sciences of the United States of America 116 (2019) 5344–5349.
date_created: 2019-03-31T21:59:13Z
date_published: 2019-03-19T00:00:00Z
date_updated: 2023-08-25T08:57:30Z
day: '19'
ddc:
- '570'
department:
- _id: EdHa
doi: 10.1073/pnas.1813255116
external_id:
isi:
- '000461679000027'
pmid:
- '30819884'
file:
- access_level: open_access
checksum: 8b67eee0ea8e5db61583e4d485215258
content_type: application/pdf
creator: dernst
date_created: 2019-04-03T14:10:30Z
date_updated: 2020-07-14T12:47:23Z
file_id: '6193'
file_name: 2019_PNAS_Recho.pdf
file_size: 3456045
relation: main_file
file_date_updated: 2020-07-14T12:47:23Z
has_accepted_license: '1'
intvolume: ' 116'
isi: 1
issue: '12'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 5344-5349
pmid: 1
project:
- _id: 268294B6-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P31639
name: Active mechano-chemical description of the cell cytoskeleton
publication: Proceedings of the National Academy of Sciences of the United States
of America
publication_identifier:
eissn:
- '10916490'
issn:
- '00278424'
publication_status: published
publisher: National Academy of Sciences
quality_controlled: '1'
related_material:
link:
- relation: supplementary_material
url: www.pnas.org/lookup/suppl/doi:10.1073/pnas.1813255116/-/DCSupplemental
scopus_import: '1'
status: public
title: Theory of mechanochemical patterning in biphasic biological tissues
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 116
year: '2019'
...
---
_id: '6508'
abstract:
- lang: eng
text: Segregation of maternal determinants within the oocyte constitutes the first
step in embryo patterning. In zebrafish oocytes, extensive ooplasmic streaming
leads to the segregation of ooplasm from yolk granules along the animal-vegetal
axis of the oocyte. Here, we show that this process does not rely on cortical
actin reorganization, as previously thought, but instead on a cell-cycle-dependent
bulk actin polymerization wave traveling from the animal to the vegetal pole of
the oocyte. This wave functions in segregation by both pulling ooplasm animally
and pushing yolk granules vegetally. Using biophysical experimentation and theory,
we show that ooplasm pulling is mediated by bulk actin network flows exerting
friction forces on the ooplasm, while yolk granule pushing is achieved by a mechanism
closely resembling actin comet formation on yolk granules. Our study defines a
novel role of cell-cycle-controlled bulk actin polymerization waves in oocyte
polarization via ooplasmic segregation.
acknowledged_ssus:
- _id: Bio
- _id: PreCl
acknowledgement: We would like to thank Pierre Recho, Guillaume Salbreux, and Silvia
Grigolon for advice on the theory, Lila Solnica-Krezel for kindly providing us with
zebrafish dachsous mutants, members of the Heisenberg and Hannezo groups for fruitful
discussions, and the Bioimaging and zebrafish facilities at IST Austria for their
continuous support. This project has received funding from the European Union (European
Research Council Advanced Grant 742573 to C.P.H.) and from the Austrian Science
Fund (FWF) (P 31639 to E.H.).
article_processing_charge: No
article_type: original
author:
- first_name: Shayan
full_name: Shamipour, Shayan
id: 40B34FE2-F248-11E8-B48F-1D18A9856A87
last_name: Shamipour
- first_name: Roland
full_name: Kardos, Roland
id: 4039350E-F248-11E8-B48F-1D18A9856A87
last_name: Kardos
- first_name: Shi-lei
full_name: Xue, Shi-lei
id: 31D2C804-F248-11E8-B48F-1D18A9856A87
last_name: Xue
- first_name: Björn
full_name: Hof, Björn
id: 3A374330-F248-11E8-B48F-1D18A9856A87
last_name: Hof
orcid: 0000-0003-2057-2754
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
citation:
ama: Shamipour S, Kardos R, Xue S, Hof B, Hannezo EB, Heisenberg C-PJ. Bulk actin
dynamics drive phase segregation in zebrafish oocytes. Cell. 2019;177(6):1463-1479.e18.
doi:10.1016/j.cell.2019.04.030
apa: Shamipour, S., Kardos, R., Xue, S., Hof, B., Hannezo, E. B., & Heisenberg,
C.-P. J. (2019). Bulk actin dynamics drive phase segregation in zebrafish oocytes.
Cell. Elsevier. https://doi.org/10.1016/j.cell.2019.04.030
chicago: Shamipour, Shayan, Roland Kardos, Shi-lei Xue, Björn Hof, Edouard B Hannezo,
and Carl-Philipp J Heisenberg. “Bulk Actin Dynamics Drive Phase Segregation in
Zebrafish Oocytes.” Cell. Elsevier, 2019. https://doi.org/10.1016/j.cell.2019.04.030.
ieee: S. Shamipour, R. Kardos, S. Xue, B. Hof, E. B. Hannezo, and C.-P. J. Heisenberg,
“Bulk actin dynamics drive phase segregation in zebrafish oocytes,” Cell,
vol. 177, no. 6. Elsevier, p. 1463–1479.e18, 2019.
ista: Shamipour S, Kardos R, Xue S, Hof B, Hannezo EB, Heisenberg C-PJ. 2019. Bulk
actin dynamics drive phase segregation in zebrafish oocytes. Cell. 177(6), 1463–1479.e18.
mla: Shamipour, Shayan, et al. “Bulk Actin Dynamics Drive Phase Segregation in Zebrafish
Oocytes.” Cell, vol. 177, no. 6, Elsevier, 2019, p. 1463–1479.e18, doi:10.1016/j.cell.2019.04.030.
short: S. Shamipour, R. Kardos, S. Xue, B. Hof, E.B. Hannezo, C.-P.J. Heisenberg,
Cell 177 (2019) 1463–1479.e18.
date_created: 2019-06-02T21:59:12Z
date_published: 2019-05-30T00:00:00Z
date_updated: 2024-03-25T23:30:21Z
day: '30'
ddc:
- '570'
department:
- _id: CaHe
- _id: EdHa
- _id: BjHo
doi: 10.1016/j.cell.2019.04.030
ec_funded: 1
external_id:
isi:
- '000469415100013'
pmid:
- '31080065'
file:
- access_level: open_access
checksum: aea43726d80e35ce3885073a5f05c3e3
content_type: application/pdf
creator: dernst
date_created: 2020-10-21T07:22:34Z
date_updated: 2020-10-21T07:22:34Z
file_id: '8686'
file_name: 2019_Cell_Shamipour_accepted.pdf
file_size: 3356292
relation: main_file
success: 1
file_date_updated: 2020-10-21T07:22:34Z
has_accepted_license: '1'
intvolume: ' 177'
isi: 1
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.cell.2019.04.030
month: '05'
oa: 1
oa_version: Published Version
page: 1463-1479.e18
pmid: 1
project:
- _id: 260F1432-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '742573'
name: Interaction and feedback between cell mechanics and fate specification in
vertebrate gastrulation
- _id: 268294B6-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P31639
name: Active mechano-chemical description of the cell cytoskeleton
publication: Cell
publication_identifier:
eissn:
- '10974172'
issn:
- '00928674'
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/how-the-cytoplasm-separates-from-the-yolk/
record:
- id: '8350'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Bulk actin dynamics drive phase segregation in zebrafish oocytes
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 177
year: '2019'
...
---
_id: '6601'
abstract:
- lang: eng
text: There is increasing evidence that both mechanical and biochemical signals
play important roles in development and disease. The development of complex organisms,
in particular, has been proposed to rely on the feedback between mechanical and
biochemical patterning events. This feedback occurs at the molecular level via
mechanosensation but can also arise as an emergent property of the system at the
cellular and tissue level. In recent years, dynamic changes in tissue geometry,
flow, rheology, and cell fate specification have emerged as key platforms of mechanochemical
feedback loops in multiple processes. Here, we review recent experimental and
theoretical advances in understanding how these feedbacks function in development
and disease.
article_processing_charge: No
article_type: review
author:
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
citation:
ama: Hannezo EB, Heisenberg C-PJ. Mechanochemical feedback loops in development
and disease. Cell. 2019;178(1):12-25. doi:10.1016/j.cell.2019.05.052
apa: Hannezo, E. B., & Heisenberg, C.-P. J. (2019). Mechanochemical feedback
loops in development and disease. Cell. Elsevier. https://doi.org/10.1016/j.cell.2019.05.052
chicago: Hannezo, Edouard B, and Carl-Philipp J Heisenberg. “Mechanochemical Feedback
Loops in Development and Disease.” Cell. Elsevier, 2019. https://doi.org/10.1016/j.cell.2019.05.052.
ieee: E. B. Hannezo and C.-P. J. Heisenberg, “Mechanochemical feedback loops in
development and disease,” Cell, vol. 178, no. 1. Elsevier, pp. 12–25, 2019.
ista: Hannezo EB, Heisenberg C-PJ. 2019. Mechanochemical feedback loops in development
and disease. Cell. 178(1), 12–25.
mla: Hannezo, Edouard B., and Carl-Philipp J. Heisenberg. “Mechanochemical Feedback
Loops in Development and Disease.” Cell, vol. 178, no. 1, Elsevier, 2019,
pp. 12–25, doi:10.1016/j.cell.2019.05.052.
short: E.B. Hannezo, C.-P.J. Heisenberg, Cell 178 (2019) 12–25.
date_created: 2019-06-30T21:59:11Z
date_published: 2019-07-27T00:00:00Z
date_updated: 2023-08-28T12:25:21Z
day: '27'
department:
- _id: CaHe
- _id: EdHa
doi: 10.1016/j.cell.2019.05.052
ec_funded: 1
external_id:
isi:
- '000473002700005'
pmid:
- '31251912'
intvolume: ' 178'
isi: 1
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.cell.2019.05.052
month: '07'
oa: 1
oa_version: Published Version
page: 12-25
pmid: 1
project:
- _id: 260F1432-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '742573'
name: Interaction and feedback between cell mechanics and fate specification in
vertebrate gastrulation
- _id: 268294B6-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P31639
name: Active mechano-chemical description of the cell cytoskeleton
publication: Cell
publication_identifier:
issn:
- '00928674'
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mechanochemical feedback loops in development and disease
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 178
year: '2019'
...